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Search of human proteins with 55953117
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2
[Homo sapiens]
(482 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 987 0.0
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 669 0.0
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 370 e-102
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 367 e-101
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 367 e-101
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 366 e-101
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 365 e-101
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 357 2e-98
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 344 9e-95
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 344 9e-95
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 334 9e-92
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 334 9e-92
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 306 2e-83
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 306 2e-83
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 306 2e-83
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 306 2e-83
gi|4502023 AKT2 kinase [Homo sapiens] 304 1e-82
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 302 4e-82
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 302 4e-82
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 299 4e-81
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 299 4e-81
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 293 2e-79
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 293 2e-79
gi|62241015 AKT1 kinase [Homo sapiens] 291 9e-79
gi|62241013 AKT1 kinase [Homo sapiens] 291 9e-79
gi|62241011 AKT1 kinase [Homo sapiens] 291 9e-79
gi|28557781 protein kinase C, eta [Homo sapiens] 277 1e-74
gi|133908623 protein kinase C, iota [Homo sapiens] 268 8e-72
gi|13384594 protein kinase C, gamma [Homo sapiens] 267 1e-71
gi|4506067 protein kinase C, alpha [Homo sapiens] 266 3e-71
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 987 bits (2551), Expect = 0.0
Identities = 482/482 (100%), Positives = 482/482 (100%)
Query: 1 MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE 60
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE
Sbjct: 1 MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPE 60
Query: 61 RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER 120
RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER
Sbjct: 61 RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAER 120
Query: 121 NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL 180
NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL
Sbjct: 121 NILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL 180
Query: 181 ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI 240
ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI
Sbjct: 181 ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI 240
Query: 241 LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV 300
LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV
Sbjct: 241 LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV 300
Query: 301 KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT 360
KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT
Sbjct: 301 KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDT 360
Query: 361 RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA 420
RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA
Sbjct: 361 RFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRA 420
Query: 421 PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP 480
PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP
Sbjct: 421 PVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRP 480
Query: 481 GR 482
GR
Sbjct: 481 GR 482
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 669 bits (1727), Expect = 0.0
Identities = 340/490 (69%), Positives = 394/490 (80%), Gaps = 19/490 (3%)
Query: 1 MAAVFDLDLETEEGSEGEGEPELSPADACPLAE-LRAAGLEP----VGHYEEVELTETSV 55
MA VFD+DL+ E + E E E + L E + G+ P + H E+ E++ETSV
Sbjct: 24 MAGVFDIDLDQPEDAGSEDELE----EGGQLNESMDHGGVGPYELGMEHCEKFEISETSV 79
Query: 56 NVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAH 115
N GPE+I P CFELLRVLGKGGYGKVFQVRKV G N GKI+AMKVL+KA IVRNAKDTAH
Sbjct: 80 NRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAH 139
Query: 116 TRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYL 175
T+AERNILE VKHPFIV+L YAFQTGGKLYLILE LSGGELF LEREGIF+EDTACFYL
Sbjct: 140 TKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYL 199
Query: 176 AEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEY 235
AEI++ALGHLH +GIIYRDLKPENIML+ QGH+KLTDFGLCKESIH+G VTHTFCGTIEY
Sbjct: 200 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 259
Query: 236 MAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPD 295
MAPEIL+RSGHNRAVDWWSLGALMYDMLTG+PPFT ENRKKT+DKI++ KL LPPYLT +
Sbjct: 260 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQE 319
Query: 296 ARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDV 355
ARDL+KK LKRN + R+G GPGDA +VQ HPFFRH+NW++LLA +V+PPF+P LQSEEDV
Sbjct: 320 ARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDV 379
Query: 356 SQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLN 415
SQFD++FTRQTPVDSPDD+ LSESANQ FLGFTYVAPSVL+S+KE FSF+PK+RSPRR
Sbjct: 380 SQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFI 439
Query: 416 SSPRAPVSPLKFSPFE----GFRPSPSLPE-PTELP-----LPPLLPPPPPSTTAPLPIR 465
SPR PVSP+KFSP + G S + P+ P E P + + +APLPIR
Sbjct: 440 GSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTMSGEASAPLPIR 499
Query: 466 PPSGTKKSKR 475
P+ K+
Sbjct: 500 QPNSGPYKKQ 509
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 370 bits (949), Expect = e-102
Identities = 188/392 (47%), Positives = 257/392 (65%), Gaps = 24/392 (6%)
Query: 37 AGLEPV---GHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLG 93
AGL+P G +E+ +T V G E+ P FELL+VLG+G +GKVF VRKV + G
Sbjct: 30 AGLQPSKDEGVLKEISITH-HVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSG 88
Query: 94 KIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSG 153
+YAMKVL+KA + +D T+ ER+IL V HPF+V+L YAFQT GKLYLIL+ L G
Sbjct: 89 HLYAMKVLKKATL--KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRG 146
Query: 154 GELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDF 213
G+LFT L +E +F E+ FYLAE+ L L HLHS GIIYRDLKPENI+L +GHIKLTDF
Sbjct: 147 GDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDF 206
Query: 214 GLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAEN 273
GL KE+I ++FCGT+EYMAPE++ R GH+ + DWWS G LM++MLTGS PF ++
Sbjct: 207 GLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKD 266
Query: 274 RKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNW 333
RK+TM I++ KL +P +L+ +A+ L++ KRNP+ R+G GP A +++RH F+ ++W
Sbjct: 267 RKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDW 326
Query: 334 DDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPS 393
+ L + PPF+P + +D FDT FT +TP DSP S A+Q F GF++VA
Sbjct: 327 NKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSP-GIPPSAGAHQLFRGFSFVATG 385
Query: 394 VLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPL 425
+++ + PRAP +PL
Sbjct: 386 LMED-----------------DGKPRAPQAPL 400
Score = 127 bits (319), Expect = 2e-29
Identities = 82/243 (33%), Positives = 127/243 (52%), Gaps = 23/243 (9%)
Query: 96 YAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGE 155
YA+KV+ K+K R+ + +L +HP I+ L + G +YL+ E + GGE
Sbjct: 444 YAVKVIDKSK--RDPSEEIEI-----LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGE 496
Query: 156 LFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGH----IKLT 211
L + R+ F E A F L I + +LHSQG+++RDLKP NI+ + +++
Sbjct: 497 LLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 556
Query: 212 DFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFT- 270
DFG K+ E + T C T ++APE+L R G++ D WSLG L+Y ML G PF
Sbjct: 557 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFAN 616
Query: 271 --AENRKKTMDKIIRGKLALP----PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQR 324
++ ++ + +I GK L ++ A+DLV K L +P QR+ A V +
Sbjct: 617 GPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQ 671
Query: 325 HPF 327
HP+
Sbjct: 672 HPW 674
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 367 bits (943), Expect = e-101
Identities = 182/357 (50%), Positives = 249/357 (69%), Gaps = 4/357 (1%)
Query: 39 LEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAM 98
LE G +E++++ V G E+ P FELL+VLG+G YGKVF VRKV+G++ G++YAM
Sbjct: 32 LEEEGVVKEIDISH-HVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAM 90
Query: 99 KVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFT 158
KVL+KA + +D ++ ER+IL V HPFIV+L YAFQT GKLYLIL+ L GG+LFT
Sbjct: 91 KVLKKATL--KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFT 148
Query: 159 HLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKE 218
L +E +F E+ FYLAE+ LAL HLHS GIIYRDLKPENI+L +GHIK+TDFGL KE
Sbjct: 149 RLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKE 208
Query: 219 SIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTM 278
+I ++FCGTIEYMAPE++ R GH ++ DWWS G LM++MLTGS PF ++RK+TM
Sbjct: 209 AIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETM 268
Query: 279 DKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLA 338
I++ KL +P +L+ +A+ L++ KRNP R+G G +++RHPFF ++W+ L
Sbjct: 269 ALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYR 328
Query: 339 WRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
+ PPF+P + ED FD FT +TP DSP S +A+ F GF++VA S++
Sbjct: 329 KEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP-GVPPSANAHHLFRGFSFVASSLI 384
Score = 128 bits (322), Expect = 1e-29
Identities = 90/273 (32%), Positives = 139/273 (50%), Gaps = 28/273 (10%)
Query: 67 FELLRVLGKGGYGKVFQ-VRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILES 125
+E+ +G G Y + V K T YA+K++ K+K R+ + +L
Sbjct: 415 YEIKEDIGVGSYSVCKRCVHKATDTE----YAVKIIDKSK--RDPSEEIEI-----LLRY 463
Query: 126 VKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHL 185
+HP I+ L + G +YL++E + GGEL + R+ F E A L IT + +L
Sbjct: 464 GQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYL 523
Query: 186 HSQGIIYRDLKPENIML----SSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEIL 241
HSQG+++RDLKP NI+ S I++ DFG K+ + T C T ++APE+L
Sbjct: 524 HSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVL 583
Query: 242 VRSGHNRAVDWWSLGALMYDMLTGSPPFT---AENRKKTMDKIIRGKLALP----PYLTP 294
R G++ A D WSLG L+Y ML G PF + ++ + +I GK AL ++
Sbjct: 584 KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISD 643
Query: 295 DARDLVKKFLKRNPSQRIGGGPGDAADVQRHPF 327
A+D+V K L +P QR+ A V +HP+
Sbjct: 644 AAKDVVSKMLHVDPHQRL-----TAMQVLKHPW 671
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 367 bits (942), Expect = e-101
Identities = 184/383 (48%), Positives = 252/383 (65%), Gaps = 21/383 (5%)
Query: 43 GHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLR 102
G +E+ +T V G E+ P FELL+VLG+G +GKVF VRKV + G +YAMKVL+
Sbjct: 48 GVLKEISITH-HVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLK 106
Query: 103 KAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLER 162
KA + +D T+ ER+IL V HPF+V+L YAFQT GKLYLIL+ L GG+LFT L +
Sbjct: 107 KATL--KVRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 164
Query: 163 EGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHE 222
E +F E+ FYLAE+ L L HLHS GIIYRDLKPENI+L +GHIKLTDFGL KE+I
Sbjct: 165 EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDH 224
Query: 223 GAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKII 282
++FCGT+EYMAPE++ R GH+ + DWWS G LM++MLTGS PF ++RK+TM I+
Sbjct: 225 EKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL 284
Query: 283 RGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVD 342
+ KL +P +L+ +A+ L++ KRNP+ R+G GP A +++RH F+ ++W+ L +
Sbjct: 285 KAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIK 344
Query: 343 PPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGF 402
PPF+P + +D FDT FT +TP DSP S A+Q F GF++VA +++
Sbjct: 345 PPFKPAVAQPDDTFYFDTEFTSRTPKDSP-GIPPSAGAHQLFRGFSFVATGLMED----- 398
Query: 403 SFQPKLRSPRRLNSSPRAPVSPL 425
+ PRAP +PL
Sbjct: 399 ------------DGKPRAPQAPL 409
Score = 127 bits (319), Expect = 2e-29
Identities = 82/243 (33%), Positives = 127/243 (52%), Gaps = 23/243 (9%)
Query: 96 YAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGE 155
YA+KV+ K+K R+ + +L +HP I+ L + G +YL+ E + GGE
Sbjct: 453 YAVKVIDKSK--RDPSEEIEI-----LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGE 505
Query: 156 LFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGH----IKLT 211
L + R+ F E A F L I + +LHSQG+++RDLKP NI+ + +++
Sbjct: 506 LLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 565
Query: 212 DFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFT- 270
DFG K+ E + T C T ++APE+L R G++ D WSLG L+Y ML G PF
Sbjct: 566 DFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFAN 625
Query: 271 --AENRKKTMDKIIRGKLALP----PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQR 324
++ ++ + +I GK L ++ A+DLV K L +P QR+ A V +
Sbjct: 626 GPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRL-----TAKQVLQ 680
Query: 325 HPF 327
HP+
Sbjct: 681 HPW 683
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 366 bits (939), Expect = e-101
Identities = 181/356 (50%), Positives = 248/356 (69%), Gaps = 4/356 (1%)
Query: 40 EPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMK 99
E G +E++++ V G E+ P FELL+VLG+G YGKVF VRKV+G++ G++YAMK
Sbjct: 41 EEEGVVKEIDISH-HVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMK 99
Query: 100 VLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTH 159
VL+KA + +D ++ ER+IL V HPFIV+L YAFQT GKLYLIL+ L GG+LFT
Sbjct: 100 VLKKATL--KVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTR 157
Query: 160 LEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKES 219
L +E +F E+ FYLAE+ LAL HLHS GIIYRDLKPENI+L +GHIK+TDFGL KE+
Sbjct: 158 LSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEA 217
Query: 220 IHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMD 279
I ++FCGTIEYMAPE++ R GH ++ DWWS G LM++MLTGS PF ++RK+TM
Sbjct: 218 IDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMA 277
Query: 280 KIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAW 339
I++ KL +P +L+ +A+ L++ KRNP R+G G +++RHPFF ++W+ L
Sbjct: 278 LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRK 337
Query: 340 RVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
+ PPF+P + ED FD FT +TP DSP S +A+ F GF++VA S++
Sbjct: 338 EIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP-GVPPSANAHHLFRGFSFVASSLI 392
Score = 128 bits (322), Expect = 1e-29
Identities = 90/273 (32%), Positives = 139/273 (50%), Gaps = 28/273 (10%)
Query: 67 FELLRVLGKGGYGKVFQ-VRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILES 125
+E+ +G G Y + V K T YA+K++ K+K R+ + +L
Sbjct: 423 YEIKEDIGVGSYSVCKRCVHKATDTE----YAVKIIDKSK--RDPSEEIEI-----LLRY 471
Query: 126 VKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHL 185
+HP I+ L + G +YL++E + GGEL + R+ F E A L IT + +L
Sbjct: 472 GQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYL 531
Query: 186 HSQGIIYRDLKPENIML----SSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEIL 241
HSQG+++RDLKP NI+ S I++ DFG K+ + T C T ++APE+L
Sbjct: 532 HSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVL 591
Query: 242 VRSGHNRAVDWWSLGALMYDMLTGSPPFT---AENRKKTMDKIIRGKLALP----PYLTP 294
R G++ A D WSLG L+Y ML G PF + ++ + +I GK AL ++
Sbjct: 592 KRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISD 651
Query: 295 DARDLVKKFLKRNPSQRIGGGPGDAADVQRHPF 327
A+D+V K L +P QR+ A V +HP+
Sbjct: 652 AAKDVVSKMLHVDPHQRL-----TAMQVLKHPW 679
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 365 bits (938), Expect = e-101
Identities = 180/350 (51%), Positives = 243/350 (69%), Gaps = 7/350 (2%)
Query: 46 EEVELTETS----VNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVL 101
EEV + E + V G E+ P FELL+VLG+G +GKVF V+K+ G++ ++YAMKVL
Sbjct: 43 EEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVL 102
Query: 102 RKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLE 161
+KA + +D T+ ER+IL V HPFIV+L YAFQT GKLYLIL+ L GG+LFT L
Sbjct: 103 KKATL--KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLS 160
Query: 162 REGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIH 221
+E +F E+ FYLAE+ LAL HLHS GIIYRDLKPENI+L +GHIKLTDFGL KESI
Sbjct: 161 KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESID 220
Query: 222 EGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKI 281
++FCGT+EYMAPE++ R GH ++ DWWS G LM++MLTG+ PF ++RK+TM I
Sbjct: 221 HEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMI 280
Query: 282 IRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRV 341
++ KL +P +L+P+A+ L++ KRNP+ R+G GP +++RH FF ++W+ L +
Sbjct: 281 LKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREI 340
Query: 342 DPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVA 391
PPF+P ED FD FT +TP DSP S +A+Q F GF++VA
Sbjct: 341 HPPFKPATGRPEDTFYFDPEFTAKTPKDSP-GIPPSANAHQLFRGFSFVA 389
Score = 138 bits (347), Expect = 1e-32
Identities = 101/316 (31%), Positives = 160/316 (50%), Gaps = 28/316 (8%)
Query: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
+E+ +G G Y V + + TN+ +A+K++ K+K +D T +L
Sbjct: 422 YEVKEDIGVGSYS-VCKRCIHKATNME--FAVKIIDKSK-----RDP--TEEIEILLRYG 471
Query: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH 186
+HP I+ L + G +Y++ E + GGEL + R+ F E A L IT + +LH
Sbjct: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531
Query: 187 SQGIIYRDLKPENIMLSSQG----HIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV 242
+QG+++RDLKP NI+ + I++ DFG K+ E + T C T ++APE+L
Sbjct: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 591
Query: 243 RSGHNRAVDWWSLGALMYDMLTGSPPFT---AENRKKTMDKIIRGKLALP----PYLTPD 295
R G++ A D WSLG L+Y MLTG PF + ++ + +I GK +L ++
Sbjct: 592 RQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDT 651
Query: 296 ARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDV 355
A+DLV K L +P QR+ AA V RHP+ H WD L ++++ P L
Sbjct: 652 AKDLVSKMLHVDPHQRL-----TAALVLRHPWIVH--WDQLPQYQLNRQDAPHLVKGAMA 704
Query: 356 SQFDTRFTRQTPVDSP 371
+ + Q+PV P
Sbjct: 705 ATYSALNRNQSPVLEP 720
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 357 bits (915), Expect = 2e-98
Identities = 180/370 (48%), Positives = 249/370 (67%), Gaps = 6/370 (1%)
Query: 30 PLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQG 89
P+ E A G +E+ +T V G E+ P FELL+VLG+G +GKVF VRK G
Sbjct: 37 PMEEGEADSCHDEGVVKEIPITH-HVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTG 95
Query: 90 TNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILE 149
+ G++YAMKVL+KA + +D T+ ER+IL V HPFIV+L YAFQT GKLYLIL+
Sbjct: 96 PDAGQLYAMKVLKKASL--KVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILD 153
Query: 150 CLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIK 209
L GG++FT L +E +F E+ FYLAE+ LAL HLH GI+YRDLKPENI+L GHIK
Sbjct: 154 FLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIK 213
Query: 210 LTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPF 269
LTDFGL KES+ + ++FCGT+EYMAPE++ R GH+++ DWWS G LM++MLTG+ PF
Sbjct: 214 LTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPF 273
Query: 270 TAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFR 329
++R +TM+ I++ KL +P +L+ +A+ L++ KRNP+ R+G +++RH FF
Sbjct: 274 QGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFFA 331
Query: 330 HMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTY 389
+++WD L V PPF+P +D FD FT +TP DSP A S +A+Q F GF++
Sbjct: 332 NIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPA-SANAHQLFKGFSF 390
Query: 390 VAPSVLDSIK 399
VA S+ + K
Sbjct: 391 VATSIAEEYK 400
Score = 117 bits (294), Expect = 2e-26
Identities = 82/276 (29%), Positives = 135/276 (48%), Gaps = 28/276 (10%)
Query: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
+EL +G G Y ++ +A+K++ K+K R+ + ++
Sbjct: 426 YELKEDIGVGSYSVC---KRCIHATTNMEFAVKIIDKSK--RDPSEEIEI-----LMRYG 475
Query: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH 186
+HP I+ L F G +YL+ + + GGEL + ++ F E A L I+ + +LH
Sbjct: 476 QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLH 535
Query: 187 SQGIIYRDLKPENIML----SSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILV 242
QG+++RDLKP NI+ +S I++ DFG K+ E + T C T ++APE+L+
Sbjct: 536 CQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLM 595
Query: 243 RSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKII----RGKLALP----PYLTP 294
+ G++ A D WSLG L Y ML G PF A T ++I+ GK +L ++
Sbjct: 596 QQGYDAACDIWSLGVLFYTMLAGYTPF-ANGPNDTPEEILLRIGNGKFSLSGGNWDNISD 654
Query: 295 DARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRH 330
A+DL+ L +P QR A + +H + H
Sbjct: 655 GAKDLLSHMLHMDPHQRY-----TAEQILKHSWITH 685
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 344 bits (883), Expect = 9e-95
Identities = 181/355 (50%), Positives = 244/355 (68%), Gaps = 10/355 (2%)
Query: 49 ELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVR 108
EL ++ E++G FELL+VLG G YGKVF VRK+ G + GK+YAMKVL+KA IV+
Sbjct: 31 ELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQ 90
Query: 109 NAKDTAHTRAERNILESVKH-PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL 167
AK T HTR ER +LE ++ PF+V L YAFQT KL+LIL+ ++GGELFTHL + F
Sbjct: 91 KAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFT 150
Query: 168 EDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVT 226
E Y+ EI LAL HLH GIIYRD+K ENI+L S GH+ LTDFGL KE + E
Sbjct: 151 EHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERA 210
Query: 227 HTFCGTIEYMAPEIL--VRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRG 284
++FCGTIEYMAP+I+ SGH++AVDWWSLG LMY++LTG+ PFT + K + +I R
Sbjct: 211 YSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRR 270
Query: 285 KL-ALPPY---LTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340
L + PPY ++ A+DL+++ L ++P +R+G GP DA +++ H FF+ +NWDDL A +
Sbjct: 271 ILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKK 330
Query: 341 VDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
V PF+P ++ E DVS F FT P SP AL +S+ + F G+++VAPS+L
Sbjct: 331 VPAPFKPVIRDELDVSNFAEEFTEMDPTYSP--AALPQSSEKLFQGYSFVAPSIL 383
Score = 64.7 bits (156), Expect = 2e-10
Identities = 38/123 (30%), Positives = 66/123 (53%), Gaps = 8/123 (6%)
Query: 77 GYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVK-HPFIVELA 135
G G RK + +A+K++ K + A+T+ E L+ + HP IV+L
Sbjct: 433 GEGSFSICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHPNIVKLH 485
Query: 136 YAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDL 195
F +L++E L+GGELF ++++ F E A + + ++ A+ H+H G+++RDL
Sbjct: 486 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 545
Query: 196 KPE 198
KPE
Sbjct: 546 KPE 548
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 344 bits (883), Expect = 9e-95
Identities = 181/355 (50%), Positives = 244/355 (68%), Gaps = 10/355 (2%)
Query: 49 ELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVR 108
EL ++ E++G FELL+VLG G YGKVF VRK+ G + GK+YAMKVL+KA IV+
Sbjct: 31 ELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQ 90
Query: 109 NAKDTAHTRAERNILESVKH-PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL 167
AK T HTR ER +LE ++ PF+V L YAFQT KL+LIL+ ++GGELFTHL + F
Sbjct: 91 KAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFT 150
Query: 168 EDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGAVT 226
E Y+ EI LAL HLH GIIYRD+K ENI+L S GH+ LTDFGL KE + E
Sbjct: 151 EHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERA 210
Query: 227 HTFCGTIEYMAPEIL--VRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRG 284
++FCGTIEYMAP+I+ SGH++AVDWWSLG LMY++LTG+ PFT + K + +I R
Sbjct: 211 YSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRR 270
Query: 285 KL-ALPPY---LTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340
L + PPY ++ A+DL+++ L ++P +R+G GP DA +++ H FF+ +NWDDL A +
Sbjct: 271 ILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKK 330
Query: 341 VDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
V PF+P ++ E DVS F FT P SP AL +S+ + F G+++VAPS+L
Sbjct: 331 VPAPFKPVIRDELDVSNFAEEFTEMDPTYSP--AALPQSSEKLFQGYSFVAPSIL 383
Score = 127 bits (318), Expect = 3e-29
Identities = 76/251 (30%), Positives = 135/251 (53%), Gaps = 22/251 (8%)
Query: 77 GYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVK-HPFIVELA 135
G G RK + +A+K++ K + A+T+ E L+ + HP IV+L
Sbjct: 433 GEGSFSICRKCVHKKSNQAFAVKIISK-------RMEANTQKEITALKLCEGHPNIVKLH 485
Query: 136 YAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDL 195
F +L++E L+GGELF ++++ F E A + + ++ A+ H+H G+++RDL
Sbjct: 486 EVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDL 545
Query: 196 KPENIMLSSQG---HIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDW 252
KPEN++ + + IK+ DFG + + T C T+ Y APE+L ++G++ + D
Sbjct: 546 KPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL 605
Query: 253 WSLGALMYDMLTGSPPFTAENRKKT-------MDKIIRGKLALP----PYLTPDARDLVK 301
WSLG ++Y ML+G PF + +R T M KI +G + ++ +A+DL++
Sbjct: 606 WSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ 665
Query: 302 KFLKRNPSQRI 312
L +P++R+
Sbjct: 666 GLLTVDPNKRL 676
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 334 bits (857), Expect = 9e-92
Identities = 178/356 (50%), Positives = 239/356 (67%), Gaps = 8/356 (2%)
Query: 47 EVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKI 106
E+ +TE ++ E++ FELL+VLG G YGKVF VRK G + GK+YAMKVLRKA +
Sbjct: 13 ELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL 72
Query: 107 VRNAKDTAHTRAERNILESVKH-PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGI 165
V+ AK HTR ER++LE V+ PF+V L YAFQT KL+LIL+ +SGGE+FTHL +
Sbjct: 73 VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
Query: 166 FLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGA 224
F E Y EI LAL HLH GIIYRDLK EN++L S+GHI LTDFGL KE + E
Sbjct: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
Query: 225 VTHTFCGTIEYMAPEIL-VRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIR 283
T +FCGTIEYMAPEI+ ++GH +AVDWWSLG L++++LTG+ PFT E + T ++ R
Sbjct: 193 RTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSR 252
Query: 284 GKL----ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAW 339
L PP + P A+DL+++ L ++P +R+G GP A +V+ HPFF+ ++W L A
Sbjct: 253 RILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAAR 312
Query: 340 RVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
++ PFRP ++SE DV F FTR PV SP + + F G+++VAPS+L
Sbjct: 313 KIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP-PPGDPRIFQGYSFVAPSIL 367
Score = 113 bits (283), Expect = 3e-25
Identities = 76/256 (29%), Positives = 131/256 (51%), Gaps = 25/256 (9%)
Query: 73 LGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIV 132
LG+G + + R+ Q G+ +A+K+L + ++ A R ++ HP +V
Sbjct: 411 LGQGSFSVCRRCRQRQS---GQEFAVKILSRRLEANTQREVAALRLCQS------HPNVV 461
Query: 133 ELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQ-GII 191
L YL+LE L GGEL H+ ++ F E A L + A+ +H + G++
Sbjct: 462 NLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 521
Query: 192 YRDLKPENIMLSSQ---GHIKLTDFGLCK-ESIHEGAVTHTFCGTIEYMAPEILVRSGHN 247
+RDLKPENI+ + +K+ DFG + G T C T++Y APE+L + G++
Sbjct: 522 HRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYD 581
Query: 248 RAVDWWSLGALMYDMLTGSPPFTAENRK-------KTMDKIIRGKLALP----PYLTPDA 296
+ D WSLG ++Y ML+G PF + + + M KI G+ +L ++ +A
Sbjct: 582 ESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEA 641
Query: 297 RDLVKKFLKRNPSQRI 312
++LV+ L +P++R+
Sbjct: 642 KELVRGLLTVDPAKRL 657
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 334 bits (857), Expect = 9e-92
Identities = 178/356 (50%), Positives = 239/356 (67%), Gaps = 8/356 (2%)
Query: 47 EVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKI 106
E+ +TE ++ E++ FELL+VLG G YGKVF VRK G + GK+YAMKVLRKA +
Sbjct: 13 ELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL 72
Query: 107 VRNAKDTAHTRAERNILESVKH-PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGI 165
V+ AK HTR ER++LE V+ PF+V L YAFQT KL+LIL+ +SGGE+FTHL +
Sbjct: 73 VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
Query: 166 FLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGA 224
F E Y EI LAL HLH GIIYRDLK EN++L S+GHI LTDFGL KE + E
Sbjct: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
Query: 225 VTHTFCGTIEYMAPEIL-VRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIR 283
T +FCGTIEYMAPEI+ ++GH +AVDWWSLG L++++LTG+ PFT E + T ++ R
Sbjct: 193 RTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSR 252
Query: 284 GKL----ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAW 339
L PP + P A+DL+++ L ++P +R+G GP A +V+ HPFF+ ++W L A
Sbjct: 253 RILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAAR 312
Query: 340 RVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
++ PFRP ++SE DV F FTR PV SP + + F G+++VAPS+L
Sbjct: 313 KIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP-PPGDPRIFQGYSFVAPSIL 367
Score = 113 bits (283), Expect = 3e-25
Identities = 76/256 (29%), Positives = 131/256 (51%), Gaps = 25/256 (9%)
Query: 73 LGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIV 132
LG+G + + R+ Q G+ +A+K+L + ++ A R ++ HP +V
Sbjct: 417 LGQGSFSVCRRCRQRQS---GQEFAVKILSRRLEANTQREVAALRLCQS------HPNVV 467
Query: 133 ELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQ-GII 191
L YL+LE L GGEL H+ ++ F E A L + A+ +H + G++
Sbjct: 468 NLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 527
Query: 192 YRDLKPENIMLSSQ---GHIKLTDFGLCK-ESIHEGAVTHTFCGTIEYMAPEILVRSGHN 247
+RDLKPENI+ + +K+ DFG + G T C T++Y APE+L + G++
Sbjct: 528 HRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYD 587
Query: 248 RAVDWWSLGALMYDMLTGSPPFTAENRK-------KTMDKIIRGKLALP----PYLTPDA 296
+ D WSLG ++Y ML+G PF + + + M KI G+ +L ++ +A
Sbjct: 588 ESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEA 647
Query: 297 RDLVKKFLKRNPSQRI 312
++LV+ L +P++R+
Sbjct: 648 KELVRGLLTVDPAKRL 663
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 306 bits (785), Expect = 2e-83
Identities = 166/353 (47%), Positives = 228/353 (64%), Gaps = 22/353 (6%)
Query: 55 VNVGPERIGPHC----FELLRVLGKGGYGKVFQVR-KVQGTNLGKIYAMKVLRKAKIVRN 109
+N+GP PH F L+V+GKG +GKV R K + YA+KVL+K I++
Sbjct: 83 INLGPSS-NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEV----FYAVKVLQKKAILKK 137
Query: 110 AKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLE 168
K+ H +ERN+L ++VKHPF+V L ++FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 138 -KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLE 196
Query: 169 DTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHT 228
A FY AEI ALG+LHS I+YRDLKPENI+L SQGHI LTDFGLCKE+I + T T
Sbjct: 197 PRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTST 256
Query: 229 FCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLAL 288
FCGT EY+APE+L + ++R VDWW LGA++Y+ML G PPF + N + D I+ L L
Sbjct: 257 FCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQL 316
Query: 289 PPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPC 348
P +T AR L++ L+++ ++R+ G D +++ H FF +NWDDL+ ++ PPF P
Sbjct: 317 KPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN 375
Query: 349 LQSEEDVSQFDTRFTRQTPV-----DSPDD---TALSESANQAFLGFTYVAPS 393
+ D+ FD FT + PV SPD TA + A +AFLGF+Y P+
Sbjct: 376 VSGPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 427
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 306 bits (785), Expect = 2e-83
Identities = 166/353 (47%), Positives = 228/353 (64%), Gaps = 22/353 (6%)
Query: 55 VNVGPERIGPHC----FELLRVLGKGGYGKVFQVR-KVQGTNLGKIYAMKVLRKAKIVRN 109
+N+GP PH F L+V+GKG +GKV R K + YA+KVL+K I++
Sbjct: 97 INLGPSS-NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEV----FYAVKVLQKKAILKK 151
Query: 110 AKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLE 168
K+ H +ERN+L ++VKHPF+V L ++FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 152 -KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLE 210
Query: 169 DTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHT 228
A FY AEI ALG+LHS I+YRDLKPENI+L SQGHI LTDFGLCKE+I + T T
Sbjct: 211 PRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTST 270
Query: 229 FCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLAL 288
FCGT EY+APE+L + ++R VDWW LGA++Y+ML G PPF + N + D I+ L L
Sbjct: 271 FCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQL 330
Query: 289 PPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPC 348
P +T AR L++ L+++ ++R+ G D +++ H FF +NWDDL+ ++ PPF P
Sbjct: 331 KPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN 389
Query: 349 LQSEEDVSQFDTRFTRQTPV-----DSPDD---TALSESANQAFLGFTYVAPS 393
+ D+ FD FT + PV SPD TA + A +AFLGF+Y P+
Sbjct: 390 VSGPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 441
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 306 bits (785), Expect = 2e-83
Identities = 166/353 (47%), Positives = 228/353 (64%), Gaps = 22/353 (6%)
Query: 55 VNVGPERIGPHC----FELLRVLGKGGYGKVFQVR-KVQGTNLGKIYAMKVLRKAKIVRN 109
+N+GP PH F L+V+GKG +GKV R K + YA+KVL+K I++
Sbjct: 111 INLGPSS-NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEV----FYAVKVLQKKAILKK 165
Query: 110 AKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLE 168
K+ H +ERN+L ++VKHPF+V L ++FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 166 -KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLE 224
Query: 169 DTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHT 228
A FY AEI ALG+LHS I+YRDLKPENI+L SQGHI LTDFGLCKE+I + T T
Sbjct: 225 PRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTST 284
Query: 229 FCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLAL 288
FCGT EY+APE+L + ++R VDWW LGA++Y+ML G PPF + N + D I+ L L
Sbjct: 285 FCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQL 344
Query: 289 PPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPC 348
P +T AR L++ L+++ ++R+ G D +++ H FF +NWDDL+ ++ PPF P
Sbjct: 345 KPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN 403
Query: 349 LQSEEDVSQFDTRFTRQTPV-----DSPDD---TALSESANQAFLGFTYVAPS 393
+ D+ FD FT + PV SPD TA + A +AFLGF+Y P+
Sbjct: 404 VSGPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 455
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 306 bits (785), Expect = 2e-83
Identities = 166/353 (47%), Positives = 228/353 (64%), Gaps = 22/353 (6%)
Query: 55 VNVGPERIGPHC----FELLRVLGKGGYGKVFQVR-KVQGTNLGKIYAMKVLRKAKIVRN 109
+N+GP PH F L+V+GKG +GKV R K + YA+KVL+K I++
Sbjct: 178 INLGPSS-NPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEV----FYAVKVLQKKAILKK 232
Query: 110 AKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLE 168
K+ H +ERN+L ++VKHPF+V L ++FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 233 -KEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLE 291
Query: 169 DTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHT 228
A FY AEI ALG+LHS I+YRDLKPENI+L SQGHI LTDFGLCKE+I + T T
Sbjct: 292 PRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTST 351
Query: 229 FCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLAL 288
FCGT EY+APE+L + ++R VDWW LGA++Y+ML G PPF + N + D I+ L L
Sbjct: 352 FCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQL 411
Query: 289 PPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPC 348
P +T AR L++ L+++ ++R+ G D +++ H FF +NWDDL+ ++ PPF P
Sbjct: 412 KPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPN 470
Query: 349 LQSEEDVSQFDTRFTRQTPV-----DSPDD---TALSESANQAFLGFTYVAPS 393
+ D+ FD FT + PV SPD TA + A +AFLGF+Y P+
Sbjct: 471 VSGPNDLRHFDPEFTEE-PVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPT 522
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 304 bits (778), Expect = 1e-82
Identities = 162/370 (43%), Positives = 229/370 (61%), Gaps = 18/370 (4%)
Query: 35 RAAGLEPVGHY-------EEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKV 87
RA G +P+ + E E +V+ ++ + F+ L++LGKG +GKV VR+
Sbjct: 113 RAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREK 172
Query: 88 QGTNLGKIYAMKVLRKAKIVRNAKD-TAHTRAERNILESVKHPFIVELAYAFQTGGKLYL 146
G+ YAMK+LRK I+ AKD AHT E +L++ +HPF+ L YAFQT +L
Sbjct: 173 A---TGRYYAMKILRKEVII--AKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCF 227
Query: 147 ILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQG 206
++E +GGELF HL RE +F E+ A FY AEI AL +LHS+ ++YRD+K EN+ML G
Sbjct: 228 VMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDG 287
Query: 207 HIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGS 266
HIK+TDFGLCKE I +GA TFCGT EY+APE+L + + RAVDWW LG +MY+M+ G
Sbjct: 288 HIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 347
Query: 267 PPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHP 326
PF ++ ++ + I+ ++ P L+P+A+ L+ LK++P QR+GGGP DA +V H
Sbjct: 348 LPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHR 407
Query: 327 FFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQ----TPVDSPDDTALSESANQ 382
FF +NW D++ ++ PPF+P + SE D FD FT Q TP D D L E +
Sbjct: 408 FFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQR 467
Query: 383 A-FLGFTYVA 391
F F+Y A
Sbjct: 468 THFPQFSYSA 477
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 302 bits (774), Expect = 4e-82
Identities = 158/344 (45%), Positives = 221/344 (64%), Gaps = 13/344 (3%)
Query: 54 SVNVGPE---RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNA 110
++N+GP P F+ L+V+GKG YGKV ++ G YA+KVL+K I++
Sbjct: 19 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKK- 74
Query: 111 KDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLED 169
K+ +H AER++L ++V+HPF+V L Y+FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 75 KEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEP 134
Query: 170 TACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTF 229
A FY AE+ A+G+LHS IIYRDLKPENI+L QGH+ LTDFGLCKE + T TF
Sbjct: 135 RARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTF 194
Query: 230 CGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALP 289
CGT EY+APE+L + ++RAVDWW LGA++Y+ML G PPF +++ + + I+ L +P
Sbjct: 195 CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIP 254
Query: 290 PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCL 349
T A DL++ L ++ QR+ G D +++ H FF +NWDDL R+ PPF P +
Sbjct: 255 GGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 313
Query: 350 QSEEDVSQFDTRFTRQTPVDS----PDDTALSESANQAFLGFTY 389
D+ FD FT++ S PD A S A+ AFLGF+Y
Sbjct: 314 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 357
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 302 bits (774), Expect = 4e-82
Identities = 158/344 (45%), Positives = 221/344 (64%), Gaps = 13/344 (3%)
Query: 54 SVNVGPE---RIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNA 110
++N+GP P F+ L+V+GKG YGKV ++ G YA+KVL+K I++
Sbjct: 79 NINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSD---GAFYAVKVLQKKSILKK- 134
Query: 111 KDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLED 169
K+ +H AER++L ++V+HPF+V L Y+FQT KLY +L+ ++GGELF HL+RE FLE
Sbjct: 135 KEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEP 194
Query: 170 TACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTF 229
A FY AE+ A+G+LHS IIYRDLKPENI+L QGH+ LTDFGLCKE + T TF
Sbjct: 195 RARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTF 254
Query: 230 CGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALP 289
CGT EY+APE+L + ++RAVDWW LGA++Y+ML G PPF +++ + + I+ L +P
Sbjct: 255 CGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIP 314
Query: 290 PYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCL 349
T A DL++ L ++ QR+ G D +++ H FF +NWDDL R+ PPF P +
Sbjct: 315 GGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 373
Query: 350 QSEEDVSQFDTRFTRQTPVDS----PDDTALSESANQAFLGFTY 389
D+ FD FT++ S PD A S A+ AFLGF+Y
Sbjct: 374 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSY 417
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 299 bits (765), Expect = 4e-81
Identities = 162/360 (45%), Positives = 231/360 (64%), Gaps = 18/360 (5%)
Query: 46 EEVELTETSVNVGPERIGPHC----FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVL 101
+++ T ++N+GP PH F+ L+V+GKG +GKV ++ GK YA+KVL
Sbjct: 138 QKLHSTSQNINLGPSG-NPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVL 193
Query: 102 RKAKIVRNAKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHL 160
+K KIV N K+ H AERN+L ++VKHPF+V L Y+FQT KLY +L+ ++GGELF HL
Sbjct: 194 QK-KIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252
Query: 161 EREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI 220
+RE F E A FY AEI ALG+LHS I+YRDLKPENI+L S GH+ LTDFGLCKE I
Sbjct: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGI 312
Query: 221 HEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDK 280
T TFCGT EY+APE++ + ++ VDWW LGA++Y+ML G PPF + + D
Sbjct: 313 AISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDN 372
Query: 281 IIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340
I+ L+L P ++ A ++++ L+++ R+ G D ++Q HPFF ++W DL+ +
Sbjct: 373 ILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQKK 431
Query: 341 VDPPFRPCLQSEEDVSQFDTRFTRQT-PVD---SPDDTALSES---ANQAFLGFTYVAPS 393
+ PPF P + +D+ FDT FT +T P S D + ++ S A+ AF+GF+Y PS
Sbjct: 432 IPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 299 bits (765), Expect = 4e-81
Identities = 162/360 (45%), Positives = 231/360 (64%), Gaps = 18/360 (5%)
Query: 46 EEVELTETSVNVGPERIGPHC----FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVL 101
+++ T ++N+GP PH F+ L+V+GKG +GKV ++ GK YA+KVL
Sbjct: 138 QKLHSTSQNINLGPSG-NPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GKFYAVKVL 193
Query: 102 RKAKIVRNAKDTAHTRAERNIL-ESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHL 160
+K KIV N K+ H AERN+L ++VKHPF+V L Y+FQT KLY +L+ ++GGELF HL
Sbjct: 194 QK-KIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHL 252
Query: 161 EREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI 220
+RE F E A FY AEI ALG+LHS I+YRDLKPENI+L S GH+ LTDFGLCKE I
Sbjct: 253 QRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGI 312
Query: 221 HEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDK 280
T TFCGT EY+APE++ + ++ VDWW LGA++Y+ML G PPF + + D
Sbjct: 313 AISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDN 372
Query: 281 IIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWR 340
I+ L+L P ++ A ++++ L+++ R+ G D ++Q HPFF ++W DL+ +
Sbjct: 373 ILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAKEDFLEIQNHPFFESLSWADLVQKK 431
Query: 341 VDPPFRPCLQSEEDVSQFDTRFTRQT-PVD---SPDDTALSES---ANQAFLGFTYVAPS 393
+ PPF P + +D+ FDT FT +T P S D + ++ S A+ AF+GF+Y PS
Sbjct: 432 IPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS 491
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 293 bits (751), Expect = 2e-79
Identities = 146/308 (47%), Positives = 202/308 (65%), Gaps = 6/308 (1%)
Query: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKD-TAHTRAERNILES 125
F+ L++LGKG +GKV VR+ GK YAMK+L+K I+ AKD AHT E +L++
Sbjct: 148 FDYLKLLGKGTFGKVILVREKAS---GKYYAMKILKKEVII--AKDEVAHTLTESRVLKN 202
Query: 126 VKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHL 185
+HPF+ L Y+FQT +L ++E ++GGELF HL RE +F ED FY AEI AL +L
Sbjct: 203 TRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYL 262
Query: 186 HSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSG 245
HS I+YRDLK EN+ML GHIK+TDFGLCKE I + A TFCGT EY+APE+L +
Sbjct: 263 HSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDND 322
Query: 246 HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLK 305
+ RAVDWW LG +MY+M+ G PF ++ +K + I+ + P L+ DA+ L+ L
Sbjct: 323 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLI 382
Query: 306 RNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQ 365
++P++R+GGGP DA ++ RH FF +NW D+ ++ PPF+P + SE D FD FT Q
Sbjct: 383 KDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQ 442
Query: 366 TPVDSPDD 373
T +P +
Sbjct: 443 TITITPPE 450
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 293 bits (751), Expect = 2e-79
Identities = 146/308 (47%), Positives = 202/308 (65%), Gaps = 6/308 (1%)
Query: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKD-TAHTRAERNILES 125
F+ L++LGKG +GKV VR+ GK YAMK+L+K I+ AKD AHT E +L++
Sbjct: 148 FDYLKLLGKGTFGKVILVREKAS---GKYYAMKILKKEVII--AKDEVAHTLTESRVLKN 202
Query: 126 VKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHL 185
+HPF+ L Y+FQT +L ++E ++GGELF HL RE +F ED FY AEI AL +L
Sbjct: 203 TRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYL 262
Query: 186 HSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSG 245
HS I+YRDLK EN+ML GHIK+TDFGLCKE I + A TFCGT EY+APE+L +
Sbjct: 263 HSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDND 322
Query: 246 HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLK 305
+ RAVDWW LG +MY+M+ G PF ++ +K + I+ + P L+ DA+ L+ L
Sbjct: 323 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLI 382
Query: 306 RNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQ 365
++P++R+GGGP DA ++ RH FF +NW D+ ++ PPF+P + SE D FD FT Q
Sbjct: 383 KDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQ 442
Query: 366 TPVDSPDD 373
T +P +
Sbjct: 443 TITITPPE 450
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 291 bits (745), Expect = 9e-79
Identities = 156/350 (44%), Positives = 217/350 (62%), Gaps = 12/350 (3%)
Query: 49 ELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVR 108
E E S+ R+ + FE L++LGKG +GKV V++ G+ YAMK+L+K IV
Sbjct: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187
Query: 109 NAKD-TAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL 167
AKD AHT E +L++ +HPF+ L Y+FQT +L ++E +GGELF HL RE +F
Sbjct: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246
Query: 168 EDTACFYLAEITLALGHLHSQ-GIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVT 226
ED A FY AEI AL +LHS+ ++YRDLK EN+ML GHIK+TDFGLCKE I +GA
Sbjct: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306
Query: 227 HTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKL 286
TFCGT EY+APE+L + + RAVDWW LG +MY+M+ G PF ++ +K + I+ ++
Sbjct: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366
Query: 287 ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFR 346
P L P+A+ L+ LK++P QR+GGG DA ++ +H FF + W + ++ PPF+
Sbjct: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426
Query: 347 PCLQSEEDVSQFDTRFTRQ----TPVDSPDDTALSESANQA-FLGFTYVA 391
P + SE D FD FT Q TP D D +S + F F+Y A
Sbjct: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 291 bits (745), Expect = 9e-79
Identities = 156/350 (44%), Positives = 217/350 (62%), Gaps = 12/350 (3%)
Query: 49 ELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVR 108
E E S+ R+ + FE L++LGKG +GKV V++ G+ YAMK+L+K IV
Sbjct: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187
Query: 109 NAKD-TAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL 167
AKD AHT E +L++ +HPF+ L Y+FQT +L ++E +GGELF HL RE +F
Sbjct: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246
Query: 168 EDTACFYLAEITLALGHLHSQ-GIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVT 226
ED A FY AEI AL +LHS+ ++YRDLK EN+ML GHIK+TDFGLCKE I +GA
Sbjct: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306
Query: 227 HTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKL 286
TFCGT EY+APE+L + + RAVDWW LG +MY+M+ G PF ++ +K + I+ ++
Sbjct: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366
Query: 287 ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFR 346
P L P+A+ L+ LK++P QR+GGG DA ++ +H FF + W + ++ PPF+
Sbjct: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426
Query: 347 PCLQSEEDVSQFDTRFTRQ----TPVDSPDDTALSESANQA-FLGFTYVA 391
P + SE D FD FT Q TP D D +S + F F+Y A
Sbjct: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 291 bits (745), Expect = 9e-79
Identities = 156/350 (44%), Positives = 217/350 (62%), Gaps = 12/350 (3%)
Query: 49 ELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVR 108
E E S+ R+ + FE L++LGKG +GKV V++ G+ YAMK+L+K IV
Sbjct: 132 EEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEVIV- 187
Query: 109 NAKD-TAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFL 167
AKD AHT E +L++ +HPF+ L Y+FQT +L ++E +GGELF HL RE +F
Sbjct: 188 -AKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFS 246
Query: 168 EDTACFYLAEITLALGHLHSQ-GIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVT 226
ED A FY AEI AL +LHS+ ++YRDLK EN+ML GHIK+TDFGLCKE I +GA
Sbjct: 247 EDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATM 306
Query: 227 HTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKL 286
TFCGT EY+APE+L + + RAVDWW LG +MY+M+ G PF ++ +K + I+ ++
Sbjct: 307 KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEI 366
Query: 287 ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFR 346
P L P+A+ L+ LK++P QR+GGG DA ++ +H FF + W + ++ PPF+
Sbjct: 367 RFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFK 426
Query: 347 PCLQSEEDVSQFDTRFTRQ----TPVDSPDDTALSESANQA-FLGFTYVA 391
P + SE D FD FT Q TP D D +S + F F+Y A
Sbjct: 427 PQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSA 476
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 277 bits (709), Expect = 1e-74
Identities = 154/376 (40%), Positives = 221/376 (58%), Gaps = 9/376 (2%)
Query: 23 LSPADACPLAELRAAG-LEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKV 81
L P + P ++L + L G E VN R+G FE +RVLGKG +GKV
Sbjct: 311 LQPGNISPTSKLVSRSTLRRQGKESSKEGNGIGVN-SSNRLGIDNFEFIRVLGKGSFGKV 369
Query: 82 FQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVK-HPFIVELAYAFQT 140
R + G +YA+KVL+K I+++ D T E+ IL + HPF+ +L FQT
Sbjct: 370 MLARVKE---TGDLYAVKVLKKDVILQD-DDVECTMTEKRILSLARNHPFLTQLFCCFQT 425
Query: 141 GGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENI 200
+L+ ++E ++GG+L H+++ F E A FY AEI AL LH +GIIYRDLK +N+
Sbjct: 426 PDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNV 485
Query: 201 MLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMY 260
+L +GH KL DFG+CKE I G T TFCGT +Y+APEIL + AVDWW++G L+Y
Sbjct: 486 LLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLY 545
Query: 261 DMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGG-GPGDA 319
+ML G PF AEN + I+ ++ P +L DA ++K F+ +NP+ R+G G
Sbjct: 546 EMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGE 605
Query: 320 ADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSES 379
+ RHPFF+ ++W L +++PPFRP ++S EDVS FD F ++ PV +P D
Sbjct: 606 HAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPM 665
Query: 380 ANQ-AFLGFTYVAPSV 394
NQ F F+YV+P +
Sbjct: 666 INQDEFRNFSYVSPEL 681
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 268 bits (685), Expect = 8e-72
Identities = 145/371 (39%), Positives = 224/371 (60%), Gaps = 17/371 (4%)
Query: 39 LEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAM 98
L+ VG +E T S +G F+LLRV+G+G Y KV VR + +IYAM
Sbjct: 227 LDQVGEEKEAMNTRESGKASSS-LGLQDFDLLRVIGRGSYAKVLLVRLKK---TDRIYAM 282
Query: 99 KVLRKAKIVRNAKDTAHTRAERNILESVK-HPFIVELAYAFQTGGKLYLILECLSGGELF 157
KV++K ++V + +D + E+++ E HPF+V L FQT +L+ ++E ++GG+L
Sbjct: 283 KVVKK-ELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLM 341
Query: 158 THLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCK 217
H++R+ E+ A FY AEI+LAL +LH +GIIYRDLK +N++L S+GHIKLTD+G+CK
Sbjct: 342 FHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCK 401
Query: 218 ESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKT 277
E + G T TFCGT Y+APEIL + +VDWW+LG LM++M+ G PF
Sbjct: 402 EGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDN 461
Query: 278 MDK---------IIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDA-ADVQRHPF 327
D+ I+ ++ +P L+ A ++K FL ++P +R+G P AD+Q HPF
Sbjct: 462 PDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF 521
Query: 328 FRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQA-FLG 386
FR+++WD + +V PPF+P + E + FD++FT + +PDD + +Q+ F G
Sbjct: 522 FRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEG 581
Query: 387 FTYVAPSVLDS 397
F Y+ P ++ +
Sbjct: 582 FEYINPLLMSA 592
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 267 bits (683), Expect = 1e-71
Identities = 156/415 (37%), Positives = 232/415 (55%), Gaps = 42/415 (10%)
Query: 23 LSPADACPLAELRAAGLEPVGHYEEVELTETSVNV-----------------GPERIGPH 65
++ AD C L + A P+ YE V + +S + P R+
Sbjct: 290 VADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHIS 349
Query: 66 CFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILE- 124
F L VLGKG +GKV + +G++ ++YA+K+L+K IV++ D T E+ +L
Sbjct: 350 DFSFLMVLGKGSFGKVMLAER-RGSD--ELYAIKILKKDVIVQD-DDVDCTLVEKRVLAL 405
Query: 125 -----SVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEIT 179
+ F+ +L FQT +LY ++E ++GG+L H+++ G F E A FY AEI
Sbjct: 406 GGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIA 465
Query: 180 LALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPE 239
+ L LH+QGIIYRDLK +N+ML ++GHIK+TDFG+CKE++ G T TFCGT +Y+APE
Sbjct: 466 IGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPE 525
Query: 240 ILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDL 299
I+ + ++VDWWS G L+Y+ML G PPF E+ ++ I+ + P L+ +A +
Sbjct: 526 IIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAI 585
Query: 300 VKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPF--RPCLQSEEDVSQ 357
K FL ++P +R+G GP ++ H FFR ++W+ L + PPF RPC +S E+
Sbjct: 586 CKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGEN--- 642
Query: 358 FDTRFTRQTPVDSPDDTALSESANQA-FLGFTYVAPSVLDSIKEGFSFQPKLRSP 411
FD FTR P +P D + S +QA F GFTYV P + P RSP
Sbjct: 643 FDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFV---------HPDARSP 688
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 266 bits (680), Expect = 3e-71
Identities = 149/401 (37%), Positives = 234/401 (58%), Gaps = 22/401 (5%)
Query: 9 LETEEGS-------EGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPER 61
L EEG EG+ E + A+L AG + + E+ + ++ +R
Sbjct: 278 LNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNL----DR 333
Query: 62 IGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERN 121
+ F L VLGKG +GKV + +GT ++YA+K+L+K ++++ D T E+
Sbjct: 334 VKLTDFNFLMVLGKGSFGKVMLADR-KGTE--ELYAIKILKKDVVIQD-DDVECTMVEKR 389
Query: 122 ILESV-KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITL 180
+L + K PF+ +L FQT +LY ++E ++GG+L H+++ G F E A FY AEI++
Sbjct: 390 VLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISI 449
Query: 181 ALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEI 240
L LH +GIIYRDLK +N+ML S+GHIK+ DFG+CKE + +G T TFCGT +Y+APEI
Sbjct: 450 GLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI 509
Query: 241 LVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLV 300
+ + ++VDWW+ G L+Y+ML G PPF E+ + I+ ++ P L+ +A +
Sbjct: 510 IAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSIC 569
Query: 301 KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRP--CLQSEEDVSQF 358
K + ++P++R+G GP DV+ H FFR ++W+ L + PPF+P C + E+ F
Sbjct: 570 KGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAEN---F 626
Query: 359 DTRFTRQTPVDSPDDTALSESANQA-FLGFTYVAPSVLDSI 398
D FTR PV +P D + + +Q+ F GF+YV P + I
Sbjct: 627 DKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPI 667
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.138 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,153,059
Number of Sequences: 37866
Number of extensions: 1275461
Number of successful extensions: 19652
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 997
Number of HSP's successfully gapped in prelim test: 618
Number of HSP's that attempted gapping in prelim test: 9568
Number of HSP's gapped (non-prelim): 6165
length of query: 482
length of database: 18,247,518
effective HSP length: 106
effective length of query: 376
effective length of database: 14,233,722
effective search space: 5351879472
effective search space used: 5351879472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.