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Search of human proteins with 55769583
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|55769583 progesterone-induced blocking factor 1 [Homo
sapiens]
(757 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|55769583 progesterone-induced blocking factor 1 [Homo sapiens] 1453 0.0
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 108 1e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 108 1e-23
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 108 2e-23
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 108 2e-23
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 108 2e-23
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 108 2e-23
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 108 2e-23
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 108 2e-23
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 108 2e-23
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 108 2e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 105 1e-22
gi|55770834 centromere protein F [Homo sapiens] 105 2e-22
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 105 2e-22
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 105 2e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 105 2e-22
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 105 2e-22
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 103 6e-22
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 101 2e-21
gi|156104908 myosin heavy chain 6 [Homo sapiens] 101 3e-21
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 100 5e-21
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 100 9e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 99 1e-20
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 98 2e-20
gi|148746195 trichohyalin [Homo sapiens] 98 3e-20
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 98 3e-20
gi|154354990 ankyrin repeat domain 26 [Homo sapiens] 97 6e-20
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 96 9e-20
gi|71061468 centromere protein E [Homo sapiens] 96 9e-20
gi|4506751 restin isoform a [Homo sapiens] 96 2e-19
>gi|55769583 progesterone-induced blocking factor 1 [Homo sapiens]
Length = 757
Score = 1453 bits (3762), Expect = 0.0
Identities = 757/757 (100%), Positives = 757/757 (100%)
Query: 1 MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNI 60
MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNI
Sbjct: 1 MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNI 60
Query: 61 QLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKY 120
QLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKY
Sbjct: 61 QLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKY 120
Query: 121 QELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIP 180
QELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIP
Sbjct: 121 QELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIP 180
Query: 181 EYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRC 240
EYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRC
Sbjct: 181 EYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRC 240
Query: 241 QRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERS 300
QRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERS
Sbjct: 241 QRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERS 300
Query: 301 ELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYE 360
ELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYE
Sbjct: 301 ELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYE 360
Query: 361 KYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAE 420
KYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAE
Sbjct: 361 KYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAE 420
Query: 421 KERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARN 480
KERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARN
Sbjct: 421 KERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARN 480
Query: 481 LTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEI 540
LTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEI
Sbjct: 481 LTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEI 540
Query: 541 IMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEH 600
IMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEH
Sbjct: 541 IMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEH 600
Query: 601 RKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
RKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE
Sbjct: 601 RKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
Query: 661 KSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKS 720
KSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKS
Sbjct: 661 KSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKS 720
Query: 721 KTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQKMKT 757
KTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQKMKT
Sbjct: 721 KTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQKMKT 757
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 108 bits (271), Expect = 1e-23
Identities = 159/710 (22%), Positives = 294/710 (41%), Gaps = 107/710 (15%)
Query: 17 SLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDN 76
+LE E+ L + + E K ++ Q+ E + + + + EL+ K + N
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1294
Query: 77 LKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
++E + LN+A + ++L +A QEL+++E RQK
Sbjct: 1295 -------EVESVTGMLNEAEGK----AIKLAKDVASLSSQLQDTQELLQEET-----RQK 1338
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
T L+ E+ R +L+D +L EE E + ++ ++S +L + +K
Sbjct: 1339 LNVSTKLRQLEEE---RNSLQD-QLDEEM--------EAKQNLERHISTLNIQLSDS-KK 1385
Query: 197 EICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADT------ 250
++ + L E + +++ LT+ YEE Y +++ RL EL D
Sbjct: 1386 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1445
Query: 251 -KQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTL 309
+QL+ + +Q +D++ +E + + + R + E E E + ++L
Sbjct: 1446 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA----------EAREKETKALSL 1495
Query: 310 EQTVTLLQKDKEYLNRQNMELSVRC---AHEEDRLERLQAQLEESKKAREEMYEKYVASR 366
+ + + KE L R N L +D + + +LE+SK+A E E+
Sbjct: 1496 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM---- 1551
Query: 367 DHYKTEYENKLHDELE-----QIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEK 421
KT+ E +L DEL+ ++RL+ N + A + +ER+ +ARD EK
Sbjct: 1552 ---KTQLE-ELEDELQATEDAKLRLEVNMQ------ALKGQFERD----LQARDEQNEEK 1597
Query: 422 ERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQ--EETAR 479
R + + E + + R L + + K+ + LK E + ++ EE +
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKL-----EGDLKDLELQADSAIKGREEAIK 1652
Query: 480 NLTQCQLECEKYQKKLE---VLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKE 536
L + Q + + +Q++LE E ++ +EK+ L+A + Q L E+ K+
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 537 LDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILK 596
A++E E+ AE + S G N KRRL+ + L+ E+ N +
Sbjct: 1713 --------ADLEKEELAEELASSLS-GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 597 D-LEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSK---------------I 640
D + Q QLS EL S + + + L ++ SK I
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823
Query: 641 DSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQ 690
+L IAQLE+ V +EK A ++ Q L+++L E+ M +
Sbjct: 1824 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1873
Score = 103 bits (258), Expect = 5e-22
Identities = 137/671 (20%), Positives = 281/671 (41%), Gaps = 66/671 (9%)
Query: 53 RKELLHNIQLLKIELSQKTMMIDNLK---VDYLTKIEELEEKLNDA---LHQKQLLTLRL 106
R EL + L+ E+ T M++ + + + L +L D L ++ L +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 107 DNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQY 166
+L +++ + Q+ + +EME ++ + N+QL D ++ L+DF T E
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDFASTVEAL 1397
Query: 167 IKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELS---TNKNQLKQLT 223
+ K + ++ E ++ ++ E K L+ KN L +EL + + +QL
Sbjct: 1398 EEGKKRFQKEI---ENLTQQYEEKAAAYDK----LEKTKNRLQQELDDLVVDLDNQRQLV 1450
Query: 224 ETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVI---E 280
E+ ++ + ++ + ++ + AD + + +E K S ALE+ + E
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET--KALSLARALEEALEAKEE 1508
Query: 281 LRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED- 339
L R +++L+A + ++ K V LE++ L+ E + Q EL ED
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 340 ------RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEID 393
++ L+ Q E +AR+E E+ EYE +L DE +Q L
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA----- 1623
Query: 394 QLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESK- 452
A+++ E + ++L D+A+ +E A+ K + Q+ D REL+ + S+
Sbjct: 1624 ----AAKKKLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASRD 1676
Query: 453 ---VTEFLHQSKLKSFESERVQLLQEETA--RNLTQCQLECEKYQKKLEVLTKEFYSLQA 507
T ++ K KS E++ +QL ++ A R Q LE E+ ++L +LQ
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736
Query: 508 SS---EKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGA 564
E RI +L+ + E Q + E + + + Q ++ NE ER A
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNM---EAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 565 NVPTTAK-RRLKQSVHLARRVLQLEKQNSLILKD--LEHRKDQVTQLSQELDRANSLLNQ 621
+ + L+ +H ++ + ++++ + + ++QV Q ++E A L Q
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853
Query: 622 TQQPYRYLIESVRQRDSKIDSLTES-------IAQLEKDVSNLNKEKSALLQTKNQMALD 674
+ + ++ V + E + QL++ + +E + + ++ +
Sbjct: 1854 KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 675 LEQLLNHREEL 685
L++ E +
Sbjct: 1914 LDEATESNEAM 1924
Score = 94.0 bits (232), Expect = 5e-19
Identities = 140/667 (20%), Positives = 289/667 (43%), Gaps = 64/667 (9%)
Query: 95 ALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRR 154
A Q+QL +++ Q++ + Y +L + + + K L LQ+ + +++
Sbjct: 814 AKRQQQLTAMKVI------QRNCAAYLKLRNWQWWRLFTKVKPL----LQVTRQEEEMQA 863
Query: 155 NLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELST 214
+ + T+E+ K E++L E + E N L++++ + + + AEE+
Sbjct: 864 KEDELQKTKERQQKA----ENELKELEQKHSQLTEEKNLLQEQL-QAETELYAEAEEMRV 918
Query: 215 NKNQLKQ-LTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA 273
KQ L E E E + R Q+L A+ K++ QQ +E ++ ++ R
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQ---AERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 274 LEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQ-----TVTLLQKDKEYLNRQNM 328
L+ E + K + LE ++ + ++LSKE LE+ T L +++++ N +
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035
Query: 329 ---------ELSVRCAHEE---DRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENK 376
EL VR EE LE+L+ +LE E A K + K
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 377 LHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHD 436
+EL+ + + EI Q NA +++ E E ++ + +++ +E+ AEK + +
Sbjct: 1096 -EEELQAALARLDDEIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 437 QLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLE 496
+L EL+ + +S T+ ++K + + + L EET + Q Q +K+ + +E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 497 VLT---KEFYSLQASSEKRITELQAQNSEHQARLDIY-----------EKLEKELDEIIM 542
LT ++F +A+ +K L+ +N++ L + +KLE ++ E+
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Query: 543 -----QTAEIENEDEAERVLFSYGYGANVPTTAK-RRLKQSVHLARRVLQLEKQNSLILK 596
+ A E D+ ++ + A+ + +K + +A QL+ L+ +
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1333
Query: 597 DLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSN 656
+ + + T+L Q + NSL +Q + +E+ + + I +L ++ +K + +
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEE----MEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 657 LNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSE--NSLLLTKTEPKHV 714
AL + K + ++E L EE AA L K ++ + + L++ + +
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 715 TENQKSK 721
N + K
Sbjct: 1450 VSNLEKK 1456
Score = 92.8 bits (229), Expect = 1e-18
Identities = 164/765 (21%), Positives = 318/765 (41%), Gaps = 113/765 (14%)
Query: 16 SSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMID 75
S L E L+ + + +E E +VR+ + E +E+LH ++ E + +
Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949
Query: 76 NLKVDYLTKIEELEEKLNDALHQKQLLTL----------RLDNQLAF---QQKDASKYQE 122
+ ++ +LEE+L + +Q L L +L++++ Q SK ++
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 123 LMKQ---EMETILLRQKQLEETNLQLREK----AGDVRRNLRDFELTEEQYIKLKAFPE- 174
L+++ ++ T L +++ + +L+ K ++ L+ E + ++ KLK E
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 175 DQLSIPEYVS---VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTE------- 224
D E ++ + EL L K+ ELQ L +E++ N LK++ E
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 225 -----TYEEDRKNYSEVQIR-----CQRLALELADT-KQLIQQGDYRQENYDKVKSERDA 273
E +N +E Q R + L EL DT Q + R + +V + A
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 274 LEQE-------VIELRRKH--EILEASHMIQTKERSE--LSKEVVTLEQTVTLLQKDKEY 322
L++E V E+R+KH + E + ++ +R++ L K TLE+ L +
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 323 LNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKY------VASRDHYKTEYENK 376
L + E+ + E +++ LQ++ + ++AR E+ +K V S E E K
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 377 LHDELEQI-----RLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDA 431
+ + +L+ QE+ Q + + R L E R N++ ++ M K
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQN 1368
Query: 432 LEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKY 491
LE+H L+ +QLS K KL+ F S V+ L+E R +
Sbjct: 1369 LERHISTLN----IQLSDSKK--------KLQDFAS-TVEALEEGKKR-----------F 1404
Query: 492 QKKLEVLTKEFYSLQASSEK----------RITELQAQNSEHQARLDIYEKLEKELDEII 541
QK++E LT+++ A+ +K + +L + + EK +++ D+++
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 542 MQTAEIENE--DEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLE 599
+ I ++ DE +R + R L++++ + + K ++DL
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 600 HRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQ-----RDSKID---SLTESIAQLE 651
KD V + EL+++ L + + +E + D+K+ ++ Q E
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 652 KDV---SNLNKEKSALLQTK-NQMALDLEQLLNHREELAAMKQIL 692
+D+ N+EK LQ + ++ +LE R AA K+ L
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Score = 65.5 bits (158), Expect = 2e-10
Identities = 112/578 (19%), Positives = 232/578 (40%), Gaps = 102/578 (17%)
Query: 11 KVNISSSLESEDISL-ETTVPTDDISSSEE--REGKVRITRQLIERKELLHNIQLLKIEL 67
K N+ + + +I L ++ D +S+ E EGK R ++ I+ L +
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE----------IENLTQQY 1415
Query: 68 SQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLT------LRLDNQLAFQQKDASKYQ 121
+K D L+ +EL++ + D +Q+QL++ + D LA ++ +SKY
Sbjct: 1416 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475
Query: 122 E-----------------LMKQEMETILLRQKQLEETNLQLREKA-------GDVRRNLR 157
+ + + +E L +++LE TN L+ + DV +N+
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535
Query: 158 DFELT--------EEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEI-CELQVKKNIL 208
+ E + EE +L+ ED+L E +R + L+ + +LQ +
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEEL-EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 209 AEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADT---------------KQL 253
E+ + QL + E++RK + ++L +L D KQL
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 254 ----IQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMI---------QTKERS 300
Q D+++E D ++ RD + E +K + LEA M + ++++
Sbjct: 1655 RKLQAQMKDFQRELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1713
Query: 301 ELSKEVVTLEQTVTL-----LQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAR 355
+L KE + E +L LQ +K L + +L E+ +E + ++ ++ +
Sbjct: 1714 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1773
Query: 356 EEMYEKYVASR-------------DHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREM 402
E++ + R + E +KLH+ ++ K I L ++
Sbjct: 1774 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 403 YERENRNLRE--ARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQS 460
E+ + RE A ++ +K++ + +E ++ ++Y+E ++V + Q
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 461 KLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVL 498
+ ES+R+ + + R L + E +++ L
Sbjct: 1894 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 37.0 bits (84), Expect = 0.068
Identities = 53/283 (18%), Positives = 114/283 (40%), Gaps = 40/283 (14%)
Query: 6 SKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKI 65
+KE++K + SLE++ + L+ + + + + K + +L + +Q K
Sbjct: 1682 AKENEKK--AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739
Query: 66 ELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMK 125
L + ++ + +E + +++ A Q + L+ L + + QK+ S Q+L +
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 126 QEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSV 185
Q E LR K L E G V+ + S +
Sbjct: 1800 QNKE---LRSK--------LHEMEGAVKSKFK--------------------STIAALEA 1828
Query: 186 RFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLAL 245
+ +L + +E E K + L +LK++ E++RK + + + ++
Sbjct: 1829 KIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--- 1881
Query: 246 ELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEIL 288
A KQL +Q + +E ++ + R L++E+ E +E +
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 108 bits (271), Expect = 1e-23
Identities = 159/710 (22%), Positives = 294/710 (41%), Gaps = 107/710 (15%)
Query: 17 SLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDN 76
+LE E+ L + + E K ++ Q+ E + + + + EL+ K + N
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQN 1287
Query: 77 LKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
++E + LN+A + ++L +A QEL+++E RQK
Sbjct: 1288 -------EVESVTGMLNEAEGK----AIKLAKDVASLSSQLQDTQELLQEET-----RQK 1331
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
T L+ E+ R +L+D +L EE E + ++ ++S +L + +K
Sbjct: 1332 LNVSTKLRQLEEE---RNSLQD-QLDEEM--------EAKQNLERHISTLNIQLSDS-KK 1378
Query: 197 EICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADT------ 250
++ + L E + +++ LT+ YEE Y +++ RL EL D
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 251 -KQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTL 309
+QL+ + +Q +D++ +E + + + R + E E E + ++L
Sbjct: 1439 QRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA----------EAREKETKALSL 1488
Query: 310 EQTVTLLQKDKEYLNRQNMELSVRC---AHEEDRLERLQAQLEESKKAREEMYEKYVASR 366
+ + + KE L R N L +D + + +LE+SK+A E E+
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEM---- 1544
Query: 367 DHYKTEYENKLHDELE-----QIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEK 421
KT+ E +L DEL+ ++RL+ N + A + +ER+ +ARD EK
Sbjct: 1545 ---KTQLE-ELEDELQATEDAKLRLEVNMQ------ALKGQFERD----LQARDEQNEEK 1590
Query: 422 ERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQ--EETAR 479
R + + E + + R L + + K+ + LK E + ++ EE +
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKL-----EGDLKDLELQADSAIKGREEAIK 1645
Query: 480 NLTQCQLECEKYQKKLE---VLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKE 536
L + Q + + +Q++LE E ++ +EK+ L+A + Q L E+ K+
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 537 LDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILK 596
A++E E+ AE + S G N KRRL+ + L+ E+ N +
Sbjct: 1706 --------ADLEKEELAEELASSLS-GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 597 D-LEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSK---------------I 640
D + Q QLS EL S + + + L ++ SK I
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816
Query: 641 DSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQ 690
+L IAQLE+ V +EK A ++ Q L+++L E+ M +
Sbjct: 1817 AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE 1866
Score = 103 bits (258), Expect = 5e-22
Identities = 137/671 (20%), Positives = 281/671 (41%), Gaps = 66/671 (9%)
Query: 53 RKELLHNIQLLKIELSQKTMMIDNLK---VDYLTKIEELEEKLNDA---LHQKQLLTLRL 106
R EL + L+ E+ T M++ + + + L +L D L ++ L +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 107 DNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQY 166
+L +++ + Q+ + +EME ++ + N+QL D ++ L+DF T E
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDFASTVEAL 1390
Query: 167 IKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELS---TNKNQLKQLT 223
+ K + ++ E ++ ++ E K L+ KN L +EL + + +QL
Sbjct: 1391 EEGKKRFQKEI---ENLTQQYEEKAAAYDK----LEKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 224 ETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVI---E 280
E+ ++ + ++ + ++ + AD + + +E K S ALE+ + E
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET--KALSLARALEEALEAKEE 1501
Query: 281 LRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED- 339
L R +++L+A + ++ K V LE++ L+ E + Q EL ED
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 340 ------RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEID 393
++ L+ Q E +AR+E E+ EYE +L DE +Q L
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA----- 1616
Query: 394 QLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESK- 452
A+++ E + ++L D+A+ +E A+ K + Q+ D REL+ + S+
Sbjct: 1617 ----AAKKKLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASRD 1669
Query: 453 ---VTEFLHQSKLKSFESERVQLLQEETA--RNLTQCQLECEKYQKKLEVLTKEFYSLQA 507
T ++ K KS E++ +QL ++ A R Q LE E+ ++L +LQ
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729
Query: 508 SS---EKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGA 564
E RI +L+ + E Q + E + + + Q ++ NE ER A
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNM---EAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 565 NVPTTAK-RRLKQSVHLARRVLQLEKQNSLILKD--LEHRKDQVTQLSQELDRANSLLNQ 621
+ + L+ +H ++ + ++++ + + ++QV Q ++E A L Q
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846
Query: 622 TQQPYRYLIESVRQRDSKIDSLTES-------IAQLEKDVSNLNKEKSALLQTKNQMALD 674
+ + ++ V + E + QL++ + +E + + ++ +
Sbjct: 1847 KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 675 LEQLLNHREEL 685
L++ E +
Sbjct: 1907 LDEATESNEAM 1917
Score = 94.0 bits (232), Expect = 5e-19
Identities = 140/667 (20%), Positives = 289/667 (43%), Gaps = 64/667 (9%)
Query: 95 ALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRR 154
A Q+QL +++ Q++ + Y +L + + + K L LQ+ + +++
Sbjct: 807 AKRQQQLTAMKVI------QRNCAAYLKLRNWQWWRLFTKVKPL----LQVTRQEEEMQA 856
Query: 155 NLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELST 214
+ + T+E+ K E++L E + E N L++++ + + + AEE+
Sbjct: 857 KEDELQKTKERQQKA----ENELKELEQKHSQLTEEKNLLQEQL-QAETELYAEAEEMRV 911
Query: 215 NKNQLKQ-LTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA 273
KQ L E E E + R Q+L A+ K++ QQ +E ++ ++ R
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQ---AERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 274 LEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQ-----TVTLLQKDKEYLNRQNM 328
L+ E + K + LE ++ + ++LSKE LE+ T L +++++ N +
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028
Query: 329 ---------ELSVRCAHEE---DRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENK 376
EL VR EE LE+L+ +LE E A K + K
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 377 LHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHD 436
+EL+ + + EI Q NA +++ E E ++ + +++ +E+ AEK + +
Sbjct: 1089 -EEELQAALARLDDEIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 437 QLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLE 496
+L EL+ + +S T+ ++K + + + L EET + Q Q +K+ + +E
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 497 VLT---KEFYSLQASSEKRITELQAQNSEHQARLDIY-----------EKLEKELDEIIM 542
LT ++F +A+ +K L+ +N++ L + +KLE ++ E+
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Query: 543 -----QTAEIENEDEAERVLFSYGYGANVPTTAK-RRLKQSVHLARRVLQLEKQNSLILK 596
+ A E D+ ++ + A+ + +K + +A QL+ L+ +
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1326
Query: 597 DLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSN 656
+ + + T+L Q + NSL +Q + +E+ + + I +L ++ +K + +
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEE----MEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 657 LNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSE--NSLLLTKTEPKHV 714
AL + K + ++E L EE AA L K ++ + + L++ + +
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 715 TENQKSK 721
N + K
Sbjct: 1443 VSNLEKK 1449
Score = 92.8 bits (229), Expect = 1e-18
Identities = 164/765 (21%), Positives = 318/765 (41%), Gaps = 113/765 (14%)
Query: 16 SSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMID 75
S L E L+ + + +E E +VR+ + E +E+LH ++ E + +
Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942
Query: 76 NLKVDYLTKIEELEEKLNDALHQKQLLTL----------RLDNQLAF---QQKDASKYQE 122
+ ++ +LEE+L + +Q L L +L++++ Q SK ++
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 123 LMKQ---EMETILLRQKQLEETNLQLREK----AGDVRRNLRDFELTEEQYIKLKAFPE- 174
L+++ ++ T L +++ + +L+ K ++ L+ E + ++ KLK E
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 175 DQLSIPEYVS---VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTE------- 224
D E ++ + EL L K+ ELQ L +E++ N LK++ E
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 225 -----TYEEDRKNYSEVQIR-----CQRLALELADT-KQLIQQGDYRQENYDKVKSERDA 273
E +N +E Q R + L EL DT Q + R + +V + A
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 274 LEQE-------VIELRRKH--EILEASHMIQTKERSE--LSKEVVTLEQTVTLLQKDKEY 322
L++E V E+R+KH + E + ++ +R++ L K TLE+ L +
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 323 LNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKY------VASRDHYKTEYENK 376
L + E+ + E +++ LQ++ + ++AR E+ +K V S E E K
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 377 LHDELEQI-----RLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDA 431
+ + +L+ QE+ Q + + R L E R N++ ++ M K
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQN 1361
Query: 432 LEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKY 491
LE+H L+ +QLS K KL+ F S V+ L+E R +
Sbjct: 1362 LERHISTLN----IQLSDSKK--------KLQDFAS-TVEALEEGKKR-----------F 1397
Query: 492 QKKLEVLTKEFYSLQASSEK----------RITELQAQNSEHQARLDIYEKLEKELDEII 541
QK++E LT+++ A+ +K + +L + + EK +++ D+++
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 542 MQTAEIENE--DEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLE 599
+ I ++ DE +R + R L++++ + + K ++DL
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 600 HRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQ-----RDSKID---SLTESIAQLE 651
KD V + EL+++ L + + +E + D+K+ ++ Q E
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577
Query: 652 KDV---SNLNKEKSALLQTK-NQMALDLEQLLNHREELAAMKQIL 692
+D+ N+EK LQ + ++ +LE R AA K+ L
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Score = 65.5 bits (158), Expect = 2e-10
Identities = 112/578 (19%), Positives = 232/578 (40%), Gaps = 102/578 (17%)
Query: 11 KVNISSSLESEDISL-ETTVPTDDISSSEE--REGKVRITRQLIERKELLHNIQLLKIEL 67
K N+ + + +I L ++ D +S+ E EGK R ++ I+ L +
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE----------IENLTQQY 1408
Query: 68 SQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLT------LRLDNQLAFQQKDASKYQ 121
+K D L+ +EL++ + D +Q+QL++ + D LA ++ +SKY
Sbjct: 1409 EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468
Query: 122 E-----------------LMKQEMETILLRQKQLEETNLQLREKA-------GDVRRNLR 157
+ + + +E L +++LE TN L+ + DV +N+
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528
Query: 158 DFELT--------EEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEI-CELQVKKNIL 208
+ E + EE +L+ ED+L E +R + L+ + +LQ +
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEEL-EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 209 AEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADT---------------KQL 253
E+ + QL + E++RK + ++L +L D KQL
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 254 ----IQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMI---------QTKERS 300
Q D+++E D ++ RD + E +K + LEA M + ++++
Sbjct: 1648 RKLQAQMKDFQRELED-ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQA 1706
Query: 301 ELSKEVVTLEQTVTL-----LQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAR 355
+L KE + E +L LQ +K L + +L E+ +E + ++ ++ +
Sbjct: 1707 DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA 1766
Query: 356 EEMYEKYVASR-------------DHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREM 402
E++ + R + E +KLH+ ++ K I L ++
Sbjct: 1767 EQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 403 YERENRNLRE--ARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQS 460
E+ + RE A ++ +K++ + +E ++ ++Y+E ++V + Q
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 461 KLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVL 498
+ ES+R+ + + R L + E +++ L
Sbjct: 1887 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 37.0 bits (84), Expect = 0.068
Identities = 53/283 (18%), Positives = 114/283 (40%), Gaps = 40/283 (14%)
Query: 6 SKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKI 65
+KE++K + SLE++ + L+ + + + + K + +L + +Q K
Sbjct: 1675 AKENEKK--AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732
Query: 66 ELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMK 125
L + ++ + +E + +++ A Q + L+ L + + QK+ S Q+L +
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 126 QEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSV 185
Q E LR K L E G V+ + S +
Sbjct: 1793 QNKE---LRSK--------LHEMEGAVKSKFK--------------------STIAALEA 1821
Query: 186 RFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLAL 245
+ +L + +E E K + L +LK++ E++RK + + + ++
Sbjct: 1822 KIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--- 1874
Query: 246 ELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEIL 288
A KQL +Q + +E ++ + R L++E+ E +E +
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 108 bits (270), Expect = 2e-23
Identities = 143/713 (20%), Positives = 297/713 (41%), Gaps = 85/713 (11%)
Query: 13 NISSSLESEDISLETTVPTDDISSSEER---EGKVRITRQLI-------ERKELLHNIQL 62
N +L S++ + +++ EER E + R+ + L +RK L ++
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQE 122
LK ++ + + + + + +++ +E QK+L + A QQK+ Q
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAA-----QKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 123 LMKQ---------EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFP 173
L ++ E E ++ EE +Q +A RR + + E +LK
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSA 2121
Query: 174 EDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
E+Q + LRKE E + + AE+ + + KQ + E K +
Sbjct: 2122 EEQAQ----ARAQAQAAAEKLRKE-AEQEAARRAQAEQAALRQ---KQAADAEMEKHKKF 2173
Query: 234 SEVQIRCQ-RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASH 292
+E +R + ++ EL + +++ D+++ D+ E L+ E E R+ +E
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEEL 2230
Query: 293 MIQTKERSELSKEVVTLE-QTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEES 351
+ ELSK +E + L+ +DK+ R E + + + RL +E+
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLR 411
+ R+ E R + + K+ E RLK E+ Q + +E+ + + R L+
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQ 2347
Query: 412 EARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ 471
E ++ + + LE +R R+L++S E++ + KL+ E R Q
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEA-----ERQRQLEMSAEAE------RLKLRVAEMSRAQ 2396
Query: 472 LLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT-----ELQAQNSEHQAR 526
EE A ++++K+ E + ++ + + ++++++T E+Q Q S+H A
Sbjct: 2397 ARAEEDA----------QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446
Query: 527 L--DIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRV 584
+ +LE+E +++ + ++ + E + + + L + L +R
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506
Query: 585 LQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDS-- 642
+E++ + + + + + QL +E R + Q +Q +E R+R + +
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 643 --LTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLL--NHREELAAMKQI 691
E + QLE+ +++ LL +NQ + QLL HR LA +++
Sbjct: 2567 RRKQEELQQLEQQ----RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Score = 90.9 bits (224), Expect = 4e-18
Identities = 155/737 (21%), Positives = 297/737 (40%), Gaps = 82/737 (11%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+ +LE+ S E + + S +E+ ++ R L E + ++ +Q+
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAE 1619
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ-ELMKQEMETIL 132
+ + + ++E + K N+AL LRL + QQK ++ + E K+E E
Sbjct: 1620 AERAREEAERELERWQLKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFE--------LTEEQYIKLKAFPEDQLSIPEYVS 184
R+ + EE ++ RE A R E++ I+L+A E E
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQR 1729
Query: 185 VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY---EEDRKNYSEVQIRCQ 241
E + L++E K+ L EL+ + +++ L + EE+ ++ SE Q
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--Q 1787
Query: 242 RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSE 301
RL E ++L ++ + ++ K +R E++ R + E + A + E +
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 302 LS-------KEVVTLEQTVTLLQKDKEYLNRQ--------NMELSVRCAH----EEDRLE 342
L KE + + L +D+ + R+ ++ R A + LE
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRN----- 397
R + +E++ + R ++ E+ +A + ++ K ELE R+++N E D LR+
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE-DTLRSKEQAE 1966
Query: 398 ----ASREMYERENRNLREARD---NAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE 450
R++ E R REA + ++A +E A K ALE+ ++L + E + E
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 451 SKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECE------KYQKKLEVLTKEFYS 504
E Q +L E+ + +L EE A Q E E + Q L+ L E +
Sbjct: 2027 RAEQESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 505 L-QASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYG 563
+A+ E +QA+ Q+R + E E + Q+AE + + A+ +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 564 ANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQ 623
A RR + R+ + + K E Q Q+ QEL L +T
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 624 QPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNH-- 681
L E +++ ++ +Q+E+++ ++ + L + K ++ + L+
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259
Query: 682 -------REELAAMKQI 691
+EE MKQ+
Sbjct: 2260 DNTQRFLQEEAEKMKQV 2276
Score = 89.4 bits (220), Expect = 1e-17
Identities = 151/674 (22%), Positives = 276/674 (40%), Gaps = 100/674 (14%)
Query: 79 VDYLTKIEELEEKLNDALH--QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
VD T EL + + + L + + +LA QQ+ A + + L E+E L +Q+
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLA--EVEAALEKQR 1373
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
QL E + Q + +A + L+ + +E+ ++ + D + +L
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431
Query: 197 EI------------CELQVKKNILAEELSTN---------KNQLKQLTETYEEDRKNYSE 235
EI L++++ I L + +L+ L EE +
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA---------------LEQEVIE 280
Q +RL ++ D Q +Q + E +VK+E +A L+ E E
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 281 LRRKHEILEASHMIQTK-ERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED 339
R + +E + +Q E ++ S E + + +K + L R E V A +
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLRE 1608
Query: 340 RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNAS 399
ER Q E+++AREE A R+ + + + +E ++RL+ + Q A
Sbjct: 1609 EAERRAQQQAEAERAREE------AERELERWQLK---ANEALRLRLQAEEVAQQKSLAQ 1659
Query: 400 REMYERENRNLREARDNAVAEKERAVMAE--KDALEKHDQLLDRYRELQLSTESKVTEFL 457
E +++ REAR AE++ E + LEK QL + + +L+ E ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL- 1718
Query: 458 HQSKLKSFESERVQLLQEETARNLTQCQLECEKYQK---KLEVLTKEFYSLQASSEKRIT 514
+++ + E +R QLL+EE AR + +K Q+ +L + E L AS +
Sbjct: 1719 -RAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 515 ELQAQNSEHQARLDI----YEKLEKE------LDEIIMQTAEIENED------EAERV-- 556
E ++ + + + RL+ + +L +E L E + ++ ED EAERV
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 557 --LFSYGYGANVPTTAK-------------RRLKQSVHLARRVLQLEKQNSLILKDLEHR 601
L + G + T A+ RRL + RR +LE+Q + D+E R
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEER 1894
Query: 602 KDQVTQLS-QELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
Q+ + S EL+R L+ T + R + E + + + A+LE ++ +
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 661 KSALLQTKNQMALD 674
L++K Q L+
Sbjct: 1955 AEDTLRSKEQAELE 1968
Score = 75.1 bits (183), Expect = 2e-13
Identities = 113/592 (19%), Positives = 255/592 (43%), Gaps = 65/592 (10%)
Query: 179 IPEYVSVRFY---------ELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
I EYV +R + + + + + + ++ ++ + ++ + + +L ++ E+
Sbjct: 1313 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372
Query: 230 RK---NYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
R+ +++ + + +R A EL Q ++ R+E + ++ ++++E+ +LR+ E
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 287 --ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERL 344
I + + ERS L +E+ + +++ E RQ E L+ L
Sbjct: 1431 AEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLEATERQR-------GGAEGELQAL 1478
Query: 345 QAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELE------------QIRLKTNQEI 392
+A+ EE++ + + E+ R + E + K E+E + + + Q +
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 393 DQLRNASREMYER-ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTES 451
++LR + E R + AR VA + AE + K ++ +L+ S +
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKL-EVLTKEFYSLQASSE 510
E + ++L+ E+ER Q E R + + E E++Q K E L + + + +
Sbjct: 1599 ---EHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 511 KRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTA 570
K + + +A+ + +A + + + E ++ + Q E E E +R L TA
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAE-EQAVRQRELAEQELEKQRQL--------AEGTA 1705
Query: 571 KRRL---KQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
++RL ++ + L Q E+Q L+ ++L + + +Q+ + L + +
Sbjct: 1706 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 628 YLIESVRQRDSKIDSLTESIAQ-LEKDVSNLNK--EKSALLQTKNQMALDLEQLLNH--R 682
L+ S + + + S +E Q LE + + E++A L+ + A QL
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 683 EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIF 734
+ A +++L + + E + L KTE + + ++++ + + ED F
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRL--KTEAEIALKEKEAENERLRRLAEDEAF 1875
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 108 bits (270), Expect = 2e-23
Identities = 143/713 (20%), Positives = 297/713 (41%), Gaps = 85/713 (11%)
Query: 13 NISSSLESEDISLETTVPTDDISSSEER---EGKVRITRQLI-------ERKELLHNIQL 62
N +L S++ + +++ EER E + R+ + L +RK L ++
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQE 122
LK ++ + + + + + +++ +E QK+L + A QQK+ Q
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQLAQEAA-----QKRLQAEEKAHAFAVQQKEQELQQT 2072
Query: 123 LMKQ---------EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFP 173
L ++ E E ++ EE +Q +A RR + + E +LK
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSA 2125
Query: 174 EDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
E+Q + LRKE E + + AE+ + + KQ + E K +
Sbjct: 2126 EEQAQ----ARAQAQAAAEKLRKE-AEQEAARRAQAEQAALRQ---KQAADAEMEKHKKF 2177
Query: 234 SEVQIRCQ-RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASH 292
+E +R + ++ EL + +++ D+++ D+ E L+ E E R+ +E
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEEL 2234
Query: 293 MIQTKERSELSKEVVTLE-QTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEES 351
+ ELSK +E + L+ +DK+ R E + + + RL +E+
Sbjct: 2235 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLR 411
+ R+ E R + + K+ E RLK E+ Q + +E+ + + R L+
Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQ 2351
Query: 412 EARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ 471
E ++ + + LE +R R+L++S E++ + KL+ E R Q
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEA-----ERQRQLEMSAEAE------RLKLRVAEMSRAQ 2400
Query: 472 LLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT-----ELQAQNSEHQAR 526
EE A ++++K+ E + ++ + + ++++++T E+Q Q S+H A
Sbjct: 2401 ARAEEDA----------QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2450
Query: 527 L--DIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRV 584
+ +LE+E +++ + ++ + E + + + L + L +R
Sbjct: 2451 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2510
Query: 585 LQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDS-- 642
+E++ + + + + + QL +E R + Q +Q +E R+R + +
Sbjct: 2511 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Query: 643 --LTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLL--NHREELAAMKQI 691
E + QLE+ +++ LL +NQ + QLL HR LA +++
Sbjct: 2571 RRKQEELQQLEQQ----RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2619
Score = 90.9 bits (224), Expect = 4e-18
Identities = 155/737 (21%), Positives = 297/737 (40%), Gaps = 82/737 (11%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+ +LE+ S E + + S +E+ ++ R L E + ++ +Q+
Sbjct: 1567 VQVALETAQRSAEAELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAE 1623
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ-ELMKQEMETIL 132
+ + + ++E + K N+AL LRL + QQK ++ + E K+E E
Sbjct: 1624 AERAREEAERELERWQLKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1677
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFE--------LTEEQYIKLKAFPEDQLSIPEYVS 184
R+ + EE ++ RE A R E++ I+L+A E E
Sbjct: 1678 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQR 1733
Query: 185 VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY---EEDRKNYSEVQIRCQ 241
E + L++E K+ L EL+ + +++ L + EE+ ++ SE Q
Sbjct: 1734 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--Q 1791
Query: 242 RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSE 301
RL E ++L ++ + ++ K +R E++ R + E + A + E +
Sbjct: 1792 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1851
Query: 302 LS-------KEVVTLEQTVTLLQKDKEYLNRQ--------NMELSVRCAH----EEDRLE 342
L KE + + L +D+ + R+ ++ R A + LE
Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1911
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRN----- 397
R + +E++ + R ++ E+ +A + ++ K ELE R+++N E D LR+
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE-DTLRSKEQAE 1970
Query: 398 ----ASREMYERENRNLREARD---NAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE 450
R++ E R REA + ++A +E A K ALE+ ++L + E + E
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 451 SKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECE------KYQKKLEVLTKEFYS 504
E Q +L E+ + +L EE A Q E E + Q L+ L E +
Sbjct: 2031 RAEQESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2089
Query: 505 L-QASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYG 563
+A+ E +QA+ Q+R + E E + Q+AE + + A+ +
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLR 2143
Query: 564 ANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQ 623
A RR + R+ + + K E Q Q+ QEL L +T
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 624 QPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNH-- 681
L E +++ ++ +Q+E+++ ++ + L + K ++ + L+
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2263
Query: 682 -------REELAAMKQI 691
+EE MKQ+
Sbjct: 2264 DNTQRFLQEEAEKMKQV 2280
Score = 89.4 bits (220), Expect = 1e-17
Identities = 151/674 (22%), Positives = 276/674 (40%), Gaps = 100/674 (14%)
Query: 79 VDYLTKIEELEEKLNDALH--QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
VD T EL + + + L + + +LA QQ+ A + + L E+E L +Q+
Sbjct: 1321 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLA--EVEAALEKQR 1377
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
QL E + Q + +A + L+ + +E+ ++ + D + +L
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1435
Query: 197 EI------------CELQVKKNILAEELSTN---------KNQLKQLTETYEEDRKNYSE 235
EI L++++ I L + +L+ L EE +
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA---------------LEQEVIE 280
Q +RL ++ D Q +Q + E +VK+E +A L+ E E
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553
Query: 281 LRRKHEILEASHMIQTK-ERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED 339
R + +E + +Q E ++ S E + + +K + L R E V A +
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLRE 1612
Query: 340 RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNAS 399
ER Q E+++AREE A R+ + + + +E ++RL+ + Q A
Sbjct: 1613 EAERRAQQQAEAERAREE------AERELERWQLK---ANEALRLRLQAEEVAQQKSLAQ 1663
Query: 400 REMYERENRNLREARDNAVAEKERAVMAE--KDALEKHDQLLDRYRELQLSTESKVTEFL 457
E +++ REAR AE++ E + LEK QL + + +L+ E ++
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL- 1722
Query: 458 HQSKLKSFESERVQLLQEETARNLTQCQLECEKYQK---KLEVLTKEFYSLQASSEKRIT 514
+++ + E +R QLL+EE AR + +K Q+ +L + E L AS +
Sbjct: 1723 -RAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780
Query: 515 ELQAQNSEHQARLDI----YEKLEKE------LDEIIMQTAEIENED------EAERV-- 556
E ++ + + + RL+ + +L +E L E + ++ ED EAERV
Sbjct: 1781 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1840
Query: 557 --LFSYGYGANVPTTAK-------------RRLKQSVHLARRVLQLEKQNSLILKDLEHR 601
L + G + T A+ RRL + RR +LE+Q + D+E R
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEER 1898
Query: 602 KDQVTQLS-QELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
Q+ + S EL+R L+ T + R + E + + + A+LE ++ +
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1958
Query: 661 KSALLQTKNQMALD 674
L++K Q L+
Sbjct: 1959 AEDTLRSKEQAELE 1972
Score = 75.1 bits (183), Expect = 2e-13
Identities = 113/592 (19%), Positives = 255/592 (43%), Gaps = 65/592 (10%)
Query: 179 IPEYVSVRFY---------ELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
I EYV +R + + + + + + ++ ++ + ++ + + +L ++ E+
Sbjct: 1317 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1376
Query: 230 RK---NYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
R+ +++ + + +R A EL Q ++ R+E + ++ ++++E+ +LR+ E
Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1434
Query: 287 --ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERL 344
I + + ERS L +E+ + +++ E RQ E L+ L
Sbjct: 1435 AEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLEATERQR-------GGAEGELQAL 1482
Query: 345 QAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELE------------QIRLKTNQEI 392
+A+ EE++ + + E+ R + E + K E+E + + + Q +
Sbjct: 1483 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1542
Query: 393 DQLRNASREMYER-ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTES 451
++LR + E R + AR VA + AE + K ++ +L+ S +
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKL-EVLTKEFYSLQASSE 510
E + ++L+ E+ER Q E R + + E E++Q K E L + + + +
Sbjct: 1603 ---EHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1658
Query: 511 KRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTA 570
K + + +A+ + +A + + + E ++ + Q E E E +R L TA
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAE-EQAVRQRELAEQELEKQRQL--------AEGTA 1709
Query: 571 KRRL---KQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
++RL ++ + L Q E+Q L+ ++L + + +Q+ + L + +
Sbjct: 1710 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1769
Query: 628 YLIESVRQRDSKIDSLTESIAQ-LEKDVSNLNK--EKSALLQTKNQMALDLEQLLNH--R 682
L+ S + + + S +E Q LE + + E++A L+ + A QL
Sbjct: 1770 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1829
Query: 683 EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIF 734
+ A +++L + + E + L KTE + + ++++ + + ED F
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRL--KTEAEIALKEKEAENERLRRLAEDEAF 1879
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 108 bits (270), Expect = 2e-23
Identities = 143/713 (20%), Positives = 297/713 (41%), Gaps = 85/713 (11%)
Query: 13 NISSSLESEDISLETTVPTDDISSSEER---EGKVRITRQLI-------ERKELLHNIQL 62
N +L S++ + +++ EER E + R+ + L +RK L ++
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQE 122
LK ++ + + + + + +++ +E QK+L + A QQK+ Q
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAA-----QKRLQAEEKAHAFAVQQKEQELQQT 2068
Query: 123 LMKQ---------EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFP 173
L ++ E E ++ EE +Q +A RR + + E +LK
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSA 2121
Query: 174 EDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
E+Q + LRKE E + + AE+ + + KQ + E K +
Sbjct: 2122 EEQAQ----ARAQAQAAAEKLRKE-AEQEAARRAQAEQAALRQ---KQAADAEMEKHKKF 2173
Query: 234 SEVQIRCQ-RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASH 292
+E +R + ++ EL + +++ D+++ D+ E L+ E E R+ +E
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEEL 2230
Query: 293 MIQTKERSELSKEVVTLE-QTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEES 351
+ ELSK +E + L+ +DK+ R E + + + RL +E+
Sbjct: 2231 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLR 411
+ R+ E R + + K+ E RLK E+ Q + +E+ + + R L+
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQ 2347
Query: 412 EARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ 471
E ++ + + LE +R R+L++S E++ + KL+ E R Q
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEA-----ERQRQLEMSAEAE------RLKLRVAEMSRAQ 2396
Query: 472 LLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT-----ELQAQNSEHQAR 526
EE A ++++K+ E + ++ + + ++++++T E+Q Q S+H A
Sbjct: 2397 ARAEEDA----------QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446
Query: 527 L--DIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRV 584
+ +LE+E +++ + ++ + E + + + L + L +R
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506
Query: 585 LQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDS-- 642
+E++ + + + + + QL +E R + Q +Q +E R+R + +
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Query: 643 --LTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLL--NHREELAAMKQI 691
E + QLE+ +++ LL +NQ + QLL HR LA +++
Sbjct: 2567 RRKQEELQQLEQQ----RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2615
Score = 90.9 bits (224), Expect = 4e-18
Identities = 155/737 (21%), Positives = 297/737 (40%), Gaps = 82/737 (11%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+ +LE+ S E + + S +E+ ++ R L E + ++ +Q+
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAE 1619
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ-ELMKQEMETIL 132
+ + + ++E + K N+AL LRL + QQK ++ + E K+E E
Sbjct: 1620 AERAREEAERELERWQLKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFE--------LTEEQYIKLKAFPEDQLSIPEYVS 184
R+ + EE ++ RE A R E++ I+L+A E E
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQR 1729
Query: 185 VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY---EEDRKNYSEVQIRCQ 241
E + L++E K+ L EL+ + +++ L + EE+ ++ SE Q
Sbjct: 1730 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--Q 1787
Query: 242 RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSE 301
RL E ++L ++ + ++ K +R E++ R + E + A + E +
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 302 LS-------KEVVTLEQTVTLLQKDKEYLNRQ--------NMELSVRCAH----EEDRLE 342
L KE + + L +D+ + R+ ++ R A + LE
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRN----- 397
R + +E++ + R ++ E+ +A + ++ K ELE R+++N E D LR+
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE-DTLRSKEQAE 1966
Query: 398 ----ASREMYERENRNLREARD---NAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE 450
R++ E R REA + ++A +E A K ALE+ ++L + E + E
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 451 SKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECE------KYQKKLEVLTKEFYS 504
E Q +L E+ + +L EE A Q E E + Q L+ L E +
Sbjct: 2027 RAEQESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2085
Query: 505 L-QASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYG 563
+A+ E +QA+ Q+R + E E + Q+AE + + A+ +
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLR 2139
Query: 564 ANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQ 623
A RR + R+ + + K E Q Q+ QEL L +T
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 624 QPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNH-- 681
L E +++ ++ +Q+E+++ ++ + L + K ++ + L+
Sbjct: 2200 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2259
Query: 682 -------REELAAMKQI 691
+EE MKQ+
Sbjct: 2260 DNTQRFLQEEAEKMKQV 2276
Score = 89.4 bits (220), Expect = 1e-17
Identities = 151/674 (22%), Positives = 276/674 (40%), Gaps = 100/674 (14%)
Query: 79 VDYLTKIEELEEKLNDALH--QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
VD T EL + + + L + + +LA QQ+ A + + L E+E L +Q+
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLA--EVEAALEKQR 1373
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
QL E + Q + +A + L+ + +E+ ++ + D + +L
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431
Query: 197 EI------------CELQVKKNILAEELSTN---------KNQLKQLTETYEEDRKNYSE 235
EI L++++ I L + +L+ L EE +
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA---------------LEQEVIE 280
Q +RL ++ D Q +Q + E +VK+E +A L+ E E
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 281 LRRKHEILEASHMIQTK-ERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED 339
R + +E + +Q E ++ S E + + +K + L R E V A +
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLRE 1608
Query: 340 RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNAS 399
ER Q E+++AREE A R+ + + + +E ++RL+ + Q A
Sbjct: 1609 EAERRAQQQAEAERAREE------AERELERWQLK---ANEALRLRLQAEEVAQQKSLAQ 1659
Query: 400 REMYERENRNLREARDNAVAEKERAVMAE--KDALEKHDQLLDRYRELQLSTESKVTEFL 457
E +++ REAR AE++ E + LEK QL + + +L+ E ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL- 1718
Query: 458 HQSKLKSFESERVQLLQEETARNLTQCQLECEKYQK---KLEVLTKEFYSLQASSEKRIT 514
+++ + E +R QLL+EE AR + +K Q+ +L + E L AS +
Sbjct: 1719 -RAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 515 ELQAQNSEHQARLDI----YEKLEKE------LDEIIMQTAEIENED------EAERV-- 556
E ++ + + + RL+ + +L +E L E + ++ ED EAERV
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 557 --LFSYGYGANVPTTAK-------------RRLKQSVHLARRVLQLEKQNSLILKDLEHR 601
L + G + T A+ RRL + RR +LE+Q + D+E R
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEER 1894
Query: 602 KDQVTQLS-QELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
Q+ + S EL+R L+ T + R + E + + + A+LE ++ +
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 661 KSALLQTKNQMALD 674
L++K Q L+
Sbjct: 1955 AEDTLRSKEQAELE 1968
Score = 75.1 bits (183), Expect = 2e-13
Identities = 113/592 (19%), Positives = 255/592 (43%), Gaps = 65/592 (10%)
Query: 179 IPEYVSVRFY---------ELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
I EYV +R + + + + + + ++ ++ + ++ + + +L ++ E+
Sbjct: 1313 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372
Query: 230 RK---NYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
R+ +++ + + +R A EL Q ++ R+E + ++ ++++E+ +LR+ E
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 287 --ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERL 344
I + + ERS L +E+ + +++ E RQ E L+ L
Sbjct: 1431 AEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLEATERQR-------GGAEGELQAL 1478
Query: 345 QAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELE------------QIRLKTNQEI 392
+A+ EE++ + + E+ R + E + K E+E + + + Q +
Sbjct: 1479 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 393 DQLRNASREMYER-ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTES 451
++LR + E R + AR VA + AE + K ++ +L+ S +
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKL-EVLTKEFYSLQASSE 510
E + ++L+ E+ER Q E R + + E E++Q K E L + + + +
Sbjct: 1599 ---EHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1654
Query: 511 KRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTA 570
K + + +A+ + +A + + + E ++ + Q E E E +R L TA
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAE-EQAVRQRELAEQELEKQRQL--------AEGTA 1705
Query: 571 KRRL---KQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
++RL ++ + L Q E+Q L+ ++L + + +Q+ + L + +
Sbjct: 1706 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 628 YLIESVRQRDSKIDSLTESIAQ-LEKDVSNLNK--EKSALLQTKNQMALDLEQLLNH--R 682
L+ S + + + S +E Q LE + + E++A L+ + A QL
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 683 EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIF 734
+ A +++L + + E + L KTE + + ++++ + + ED F
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRL--KTEAEIALKEKEAENERLRRLAEDEAF 1875
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 108 bits (270), Expect = 2e-23
Identities = 143/713 (20%), Positives = 297/713 (41%), Gaps = 85/713 (11%)
Query: 13 NISSSLESEDISLETTVPTDDISSSEER---EGKVRITRQLI-------ERKELLHNIQL 62
N +L S++ + +++ EER E + R+ + L +RK L ++
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQE 122
LK ++ + + + + + +++ +E QK+L + A QQK+ Q
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQLAQEAA-----QKRLQAEEKAHAFAVQQKEQELQQT 2036
Query: 123 LMKQ---------EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFP 173
L ++ E E ++ EE +Q +A RR + + E +LK
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSA 2089
Query: 174 EDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
E+Q + LRKE E + + AE+ + + KQ + E K +
Sbjct: 2090 EEQAQ----ARAQAQAAAEKLRKE-AEQEAARRAQAEQAALRQ---KQAADAEMEKHKKF 2141
Query: 234 SEVQIRCQ-RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASH 292
+E +R + ++ EL + +++ D+++ D+ E L+ E E R+ +E
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEEL 2198
Query: 293 MIQTKERSELSKEVVTLE-QTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEES 351
+ ELSK +E + L+ +DK+ R E + + + RL +E+
Sbjct: 2199 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLR 411
+ R+ E R + + K+ E RLK E+ Q + +E+ + + R L+
Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQ 2315
Query: 412 EARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ 471
E ++ + + LE +R R+L++S E++ + KL+ E R Q
Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEA-----ERQRQLEMSAEAE------RLKLRVAEMSRAQ 2364
Query: 472 LLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT-----ELQAQNSEHQAR 526
EE A ++++K+ E + ++ + + ++++++T E+Q Q S+H A
Sbjct: 2365 ARAEEDA----------QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2414
Query: 527 L--DIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRV 584
+ +LE+E +++ + ++ + E + + + L + L +R
Sbjct: 2415 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2474
Query: 585 LQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDS-- 642
+E++ + + + + + QL +E R + Q +Q +E R+R + +
Sbjct: 2475 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Query: 643 --LTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLL--NHREELAAMKQI 691
E + QLE+ +++ LL +NQ + QLL HR LA +++
Sbjct: 2535 RRKQEELQQLEQQ----RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2583
Score = 90.9 bits (224), Expect = 4e-18
Identities = 155/737 (21%), Positives = 297/737 (40%), Gaps = 82/737 (11%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+ +LE+ S E + + S +E+ ++ R L E + ++ +Q+
Sbjct: 1531 VQVALETAQRSAEAELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAE 1587
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ-ELMKQEMETIL 132
+ + + ++E + K N+AL LRL + QQK ++ + E K+E E
Sbjct: 1588 AERAREEAERELERWQLKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1641
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFE--------LTEEQYIKLKAFPEDQLSIPEYVS 184
R+ + EE ++ RE A R E++ I+L+A E E
Sbjct: 1642 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQR 1697
Query: 185 VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY---EEDRKNYSEVQIRCQ 241
E + L++E K+ L EL+ + +++ L + EE+ ++ SE Q
Sbjct: 1698 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--Q 1755
Query: 242 RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSE 301
RL E ++L ++ + ++ K +R E++ R + E + A + E +
Sbjct: 1756 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1815
Query: 302 LS-------KEVVTLEQTVTLLQKDKEYLNRQ--------NMELSVRCAH----EEDRLE 342
L KE + + L +D+ + R+ ++ R A + LE
Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1875
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRN----- 397
R + +E++ + R ++ E+ +A + ++ K ELE R+++N E D LR+
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE-DTLRSKEQAE 1934
Query: 398 ----ASREMYERENRNLREARD---NAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE 450
R++ E R REA + ++A +E A K ALE+ ++L + E + E
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994
Query: 451 SKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECE------KYQKKLEVLTKEFYS 504
E Q +L E+ + +L EE A Q E E + Q L+ L E +
Sbjct: 1995 RAEQESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2053
Query: 505 L-QASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYG 563
+A+ E +QA+ Q+R + E E + Q+AE + + A+ +
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLR 2107
Query: 564 ANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQ 623
A RR + R+ + + K E Q Q+ QEL L +T
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 624 QPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNH-- 681
L E +++ ++ +Q+E+++ ++ + L + K ++ + L+
Sbjct: 2168 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2227
Query: 682 -------REELAAMKQI 691
+EE MKQ+
Sbjct: 2228 DNTQRFLQEEAEKMKQV 2244
Score = 89.4 bits (220), Expect = 1e-17
Identities = 151/674 (22%), Positives = 276/674 (40%), Gaps = 100/674 (14%)
Query: 79 VDYLTKIEELEEKLNDALH--QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
VD T EL + + + L + + +LA QQ+ A + + L E+E L +Q+
Sbjct: 1285 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLA--EVEAALEKQR 1341
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
QL E + Q + +A + L+ + +E+ ++ + D + +L
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1399
Query: 197 EI------------CELQVKKNILAEELSTN---------KNQLKQLTETYEEDRKNYSE 235
EI L++++ I L + +L+ L EE +
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA---------------LEQEVIE 280
Q +RL ++ D Q +Q + E +VK+E +A L+ E E
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517
Query: 281 LRRKHEILEASHMIQTK-ERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED 339
R + +E + +Q E ++ S E + + +K + L R E V A +
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLRE 1576
Query: 340 RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNAS 399
ER Q E+++AREE A R+ + + + +E ++RL+ + Q A
Sbjct: 1577 EAERRAQQQAEAERAREE------AERELERWQLK---ANEALRLRLQAEEVAQQKSLAQ 1627
Query: 400 REMYERENRNLREARDNAVAEKERAVMAE--KDALEKHDQLLDRYRELQLSTESKVTEFL 457
E +++ REAR AE++ E + LEK QL + + +L+ E ++
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL- 1686
Query: 458 HQSKLKSFESERVQLLQEETARNLTQCQLECEKYQK---KLEVLTKEFYSLQASSEKRIT 514
+++ + E +R QLL+EE AR + +K Q+ +L + E L AS +
Sbjct: 1687 -RAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744
Query: 515 ELQAQNSEHQARLDI----YEKLEKE------LDEIIMQTAEIENED------EAERV-- 556
E ++ + + + RL+ + +L +E L E + ++ ED EAERV
Sbjct: 1745 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1804
Query: 557 --LFSYGYGANVPTTAK-------------RRLKQSVHLARRVLQLEKQNSLILKDLEHR 601
L + G + T A+ RRL + RR +LE+Q + D+E R
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEER 1862
Query: 602 KDQVTQLS-QELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
Q+ + S EL+R L+ T + R + E + + + A+LE ++ +
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1922
Query: 661 KSALLQTKNQMALD 674
L++K Q L+
Sbjct: 1923 AEDTLRSKEQAELE 1936
Score = 75.1 bits (183), Expect = 2e-13
Identities = 113/592 (19%), Positives = 255/592 (43%), Gaps = 65/592 (10%)
Query: 179 IPEYVSVRFY---------ELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
I EYV +R + + + + + + ++ ++ + ++ + + +L ++ E+
Sbjct: 1281 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1340
Query: 230 RK---NYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
R+ +++ + + +R A EL Q ++ R+E + ++ ++++E+ +LR+ E
Sbjct: 1341 RQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1398
Query: 287 --ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERL 344
I + + ERS L +E+ + +++ E RQ E L+ L
Sbjct: 1399 AEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLEATERQR-------GGAEGELQAL 1446
Query: 345 QAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELE------------QIRLKTNQEI 392
+A+ EE++ + + E+ R + E + K E+E + + + Q +
Sbjct: 1447 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1506
Query: 393 DQLRNASREMYER-ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTES 451
++LR + E R + AR VA + AE + K ++ +L+ S +
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKL-EVLTKEFYSLQASSE 510
E + ++L+ E+ER Q E R + + E E++Q K E L + + + +
Sbjct: 1567 ---EHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1622
Query: 511 KRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTA 570
K + + +A+ + +A + + + E ++ + Q E E E +R L TA
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAE-EQAVRQRELAEQELEKQRQL--------AEGTA 1673
Query: 571 KRRL---KQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
++RL ++ + L Q E+Q L+ ++L + + +Q+ + L + +
Sbjct: 1674 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1733
Query: 628 YLIESVRQRDSKIDSLTESIAQ-LEKDVSNLNK--EKSALLQTKNQMALDLEQLLNH--R 682
L+ S + + + S +E Q LE + + E++A L+ + A QL
Sbjct: 1734 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1793
Query: 683 EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIF 734
+ A +++L + + E + L KTE + + ++++ + + ED F
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRL--KTEAEIALKEKEAENERLRRLAEDEAF 1843
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 108 bits (270), Expect = 2e-23
Identities = 143/713 (20%), Positives = 297/713 (41%), Gaps = 85/713 (11%)
Query: 13 NISSSLESEDISLETTVPTDDISSSEER---EGKVRITRQLI-------ERKELLHNIQL 62
N +L S++ + +++ EER E + R+ + L +RK L ++
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQE 122
LK ++ + + + + + +++ +E QK+L + A QQK+ Q
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAA-----QKRLQAEEKAHAFAVQQKEQELQQT 2205
Query: 123 LMKQ---------EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFP 173
L ++ E E ++ EE +Q +A RR + + E +LK
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSA 2258
Query: 174 EDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
E+Q + LRKE E + + AE+ + + KQ + E K +
Sbjct: 2259 EEQAQ----ARAQAQAAAEKLRKE-AEQEAARRAQAEQAALRQ---KQAADAEMEKHKKF 2310
Query: 234 SEVQIRCQ-RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASH 292
+E +R + ++ EL + +++ D+++ D+ E L+ E E R+ +E
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEEL 2367
Query: 293 MIQTKERSELSKEVVTLE-QTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEES 351
+ ELSK +E + L+ +DK+ R E + + + RL +E+
Sbjct: 2368 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLR 411
+ R+ E R + + K+ E RLK E+ Q + +E+ + + R L+
Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQ 2484
Query: 412 EARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ 471
E ++ + + LE +R R+L++S E++ + KL+ E R Q
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEA-----ERQRQLEMSAEAE------RLKLRVAEMSRAQ 2533
Query: 472 LLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT-----ELQAQNSEHQAR 526
EE A ++++K+ E + ++ + + ++++++T E+Q Q S+H A
Sbjct: 2534 ARAEEDA----------QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2583
Query: 527 L--DIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRV 584
+ +LE+E +++ + ++ + E + + + L + L +R
Sbjct: 2584 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2643
Query: 585 LQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDS-- 642
+E++ + + + + + QL +E R + Q +Q +E R+R + +
Sbjct: 2644 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Query: 643 --LTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLL--NHREELAAMKQI 691
E + QLE+ +++ LL +NQ + QLL HR LA +++
Sbjct: 2704 RRKQEELQQLEQQ----RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2752
Score = 90.9 bits (224), Expect = 4e-18
Identities = 155/737 (21%), Positives = 297/737 (40%), Gaps = 82/737 (11%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+ +LE+ S E + + S +E+ ++ R L E + ++ +Q+
Sbjct: 1700 VQVALETAQRSAEAELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAE 1756
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ-ELMKQEMETIL 132
+ + + ++E + K N+AL LRL + QQK ++ + E K+E E
Sbjct: 1757 AERAREEAERELERWQLKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1810
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFE--------LTEEQYIKLKAFPEDQLSIPEYVS 184
R+ + EE ++ RE A R E++ I+L+A E E
Sbjct: 1811 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQR 1866
Query: 185 VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY---EEDRKNYSEVQIRCQ 241
E + L++E K+ L EL+ + +++ L + EE+ ++ SE Q
Sbjct: 1867 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--Q 1924
Query: 242 RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSE 301
RL E ++L ++ + ++ K +R E++ R + E + A + E +
Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1984
Query: 302 LS-------KEVVTLEQTVTLLQKDKEYLNRQ--------NMELSVRCAH----EEDRLE 342
L KE + + L +D+ + R+ ++ R A + LE
Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 2044
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRN----- 397
R + +E++ + R ++ E+ +A + ++ K ELE R+++N E D LR+
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE-DTLRSKEQAE 2103
Query: 398 ----ASREMYERENRNLREARD---NAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE 450
R++ E R REA + ++A +E A K ALE+ ++L + E + E
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163
Query: 451 SKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECE------KYQKKLEVLTKEFYS 504
E Q +L E+ + +L EE A Q E E + Q L+ L E +
Sbjct: 2164 RAEQESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2222
Query: 505 L-QASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYG 563
+A+ E +QA+ Q+R + E E + Q+AE + + A+ +
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLR 2276
Query: 564 ANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQ 623
A RR + R+ + + K E Q Q+ QEL L +T
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 624 QPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNH-- 681
L E +++ ++ +Q+E+++ ++ + L + K ++ + L+
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2396
Query: 682 -------REELAAMKQI 691
+EE MKQ+
Sbjct: 2397 DNTQRFLQEEAEKMKQV 2413
Score = 89.4 bits (220), Expect = 1e-17
Identities = 151/674 (22%), Positives = 276/674 (40%), Gaps = 100/674 (14%)
Query: 79 VDYLTKIEELEEKLNDALH--QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
VD T EL + + + L + + +LA QQ+ A + + L E+E L +Q+
Sbjct: 1454 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLA--EVEAALEKQR 1510
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
QL E + Q + +A + L+ + +E+ ++ + D + +L
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1568
Query: 197 EI------------CELQVKKNILAEELSTN---------KNQLKQLTETYEEDRKNYSE 235
EI L++++ I L + +L+ L EE +
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA---------------LEQEVIE 280
Q +RL ++ D Q +Q + E +VK+E +A L+ E E
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686
Query: 281 LRRKHEILEASHMIQTK-ERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED 339
R + +E + +Q E ++ S E + + +K + L R E V A +
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLRE 1745
Query: 340 RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNAS 399
ER Q E+++AREE A R+ + + + +E ++RL+ + Q A
Sbjct: 1746 EAERRAQQQAEAERAREE------AERELERWQLK---ANEALRLRLQAEEVAQQKSLAQ 1796
Query: 400 REMYERENRNLREARDNAVAEKERAVMAE--KDALEKHDQLLDRYRELQLSTESKVTEFL 457
E +++ REAR AE++ E + LEK QL + + +L+ E ++
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL- 1855
Query: 458 HQSKLKSFESERVQLLQEETARNLTQCQLECEKYQK---KLEVLTKEFYSLQASSEKRIT 514
+++ + E +R QLL+EE AR + +K Q+ +L + E L AS +
Sbjct: 1856 -RAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913
Query: 515 ELQAQNSEHQARLDI----YEKLEKE------LDEIIMQTAEIENED------EAERV-- 556
E ++ + + + RL+ + +L +E L E + ++ ED EAERV
Sbjct: 1914 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1973
Query: 557 --LFSYGYGANVPTTAK-------------RRLKQSVHLARRVLQLEKQNSLILKDLEHR 601
L + G + T A+ RRL + RR +LE+Q + D+E R
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEER 2031
Query: 602 KDQVTQLS-QELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
Q+ + S EL+R L+ T + R + E + + + A+LE ++ +
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091
Query: 661 KSALLQTKNQMALD 674
L++K Q L+
Sbjct: 2092 AEDTLRSKEQAELE 2105
Score = 75.1 bits (183), Expect = 2e-13
Identities = 113/592 (19%), Positives = 255/592 (43%), Gaps = 65/592 (10%)
Query: 179 IPEYVSVRFY---------ELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
I EYV +R + + + + + + ++ ++ + ++ + + +L ++ E+
Sbjct: 1450 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1509
Query: 230 RK---NYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
R+ +++ + + +R A EL Q ++ R+E + ++ ++++E+ +LR+ E
Sbjct: 1510 RQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1567
Query: 287 --ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERL 344
I + + ERS L +E+ + +++ E RQ E L+ L
Sbjct: 1568 AEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLEATERQR-------GGAEGELQAL 1615
Query: 345 QAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELE------------QIRLKTNQEI 392
+A+ EE++ + + E+ R + E + K E+E + + + Q +
Sbjct: 1616 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1675
Query: 393 DQLRNASREMYER-ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTES 451
++LR + E R + AR VA + AE + K ++ +L+ S +
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKL-EVLTKEFYSLQASSE 510
E + ++L+ E+ER Q E R + + E E++Q K E L + + + +
Sbjct: 1736 ---EHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1791
Query: 511 KRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTA 570
K + + +A+ + +A + + + E ++ + Q E E E +R L TA
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAE-EQAVRQRELAEQELEKQRQL--------AEGTA 1842
Query: 571 KRRL---KQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
++RL ++ + L Q E+Q L+ ++L + + +Q+ + L + +
Sbjct: 1843 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1902
Query: 628 YLIESVRQRDSKIDSLTESIAQ-LEKDVSNLNK--EKSALLQTKNQMALDLEQLLNH--R 682
L+ S + + + S +E Q LE + + E++A L+ + A QL
Sbjct: 1903 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1962
Query: 683 EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIF 734
+ A +++L + + E + L KTE + + ++++ + + ED F
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRL--KTEAEIALKEKEAENERLRRLAEDEAF 2012
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 108 bits (270), Expect = 2e-23
Identities = 143/713 (20%), Positives = 297/713 (41%), Gaps = 85/713 (11%)
Query: 13 NISSSLESEDISLETTVPTDDISSSEER---EGKVRITRQLI-------ERKELLHNIQL 62
N +L S++ + +++ EER E + R+ + L +RK L ++
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQE 122
LK ++ + + + + + +++ +E QK+L + A QQK+ Q
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAA-----QKRLQAEEKAHAFAVQQKEQELQQT 2046
Query: 123 LMKQ---------EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFP 173
L ++ E E ++ EE +Q +A RR + + E +LK
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSA 2099
Query: 174 EDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
E+Q + LRKE E + + AE+ + + KQ + E K +
Sbjct: 2100 EEQAQ----ARAQAQAAAEKLRKE-AEQEAARRAQAEQAALRQ---KQAADAEMEKHKKF 2151
Query: 234 SEVQIRCQ-RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASH 292
+E +R + ++ EL + +++ D+++ D+ E L+ E E R+ +E
Sbjct: 2152 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEEL 2208
Query: 293 MIQTKERSELSKEVVTLE-QTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEES 351
+ ELSK +E + L+ +DK+ R E + + + RL +E+
Sbjct: 2209 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLR 411
+ R+ E R + + K+ E RLK E+ Q + +E+ + + R L+
Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQ 2325
Query: 412 EARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ 471
E ++ + + LE +R R+L++S E++ + KL+ E R Q
Sbjct: 2326 EDKEQMAQQLAEETQGFQRTLEA-----ERQRQLEMSAEAE------RLKLRVAEMSRAQ 2374
Query: 472 LLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT-----ELQAQNSEHQAR 526
EE A ++++K+ E + ++ + + ++++++T E+Q Q S+H A
Sbjct: 2375 ARAEEDA----------QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2424
Query: 527 L--DIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRV 584
+ +LE+E +++ + ++ + E + + + L + L +R
Sbjct: 2425 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2484
Query: 585 LQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDS-- 642
+E++ + + + + + QL +E R + Q +Q +E R+R + +
Sbjct: 2485 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Query: 643 --LTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLL--NHREELAAMKQI 691
E + QLE+ +++ LL +NQ + QLL HR LA +++
Sbjct: 2545 RRKQEELQQLEQQ----RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2593
Score = 90.9 bits (224), Expect = 4e-18
Identities = 155/737 (21%), Positives = 297/737 (40%), Gaps = 82/737 (11%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+ +LE+ S E + + S +E+ ++ R L E + ++ +Q+
Sbjct: 1541 VQVALETAQRSAEAELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAE 1597
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ-ELMKQEMETIL 132
+ + + ++E + K N+AL LRL + QQK ++ + E K+E E
Sbjct: 1598 AERAREEAERELERWQLKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1651
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFE--------LTEEQYIKLKAFPEDQLSIPEYVS 184
R+ + EE ++ RE A R E++ I+L+A E E
Sbjct: 1652 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQR 1707
Query: 185 VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY---EEDRKNYSEVQIRCQ 241
E + L++E K+ L EL+ + +++ L + EE+ ++ SE Q
Sbjct: 1708 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--Q 1765
Query: 242 RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSE 301
RL E ++L ++ + ++ K +R E++ R + E + A + E +
Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1825
Query: 302 LS-------KEVVTLEQTVTLLQKDKEYLNRQ--------NMELSVRCAH----EEDRLE 342
L KE + + L +D+ + R+ ++ R A + LE
Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1885
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRN----- 397
R + +E++ + R ++ E+ +A + ++ K ELE R+++N E D LR+
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE-DTLRSKEQAE 1944
Query: 398 ----ASREMYERENRNLREARD---NAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE 450
R++ E R REA + ++A +E A K ALE+ ++L + E + E
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 451 SKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECE------KYQKKLEVLTKEFYS 504
E Q +L E+ + +L EE A Q E E + Q L+ L E +
Sbjct: 2005 RAEQESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2063
Query: 505 L-QASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYG 563
+A+ E +QA+ Q+R + E E + Q+AE + + A+ +
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLR 2117
Query: 564 ANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQ 623
A RR + R+ + + K E Q Q+ QEL L +T
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 624 QPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNH-- 681
L E +++ ++ +Q+E+++ ++ + L + K ++ + L+
Sbjct: 2178 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2237
Query: 682 -------REELAAMKQI 691
+EE MKQ+
Sbjct: 2238 DNTQRFLQEEAEKMKQV 2254
Score = 89.4 bits (220), Expect = 1e-17
Identities = 151/674 (22%), Positives = 276/674 (40%), Gaps = 100/674 (14%)
Query: 79 VDYLTKIEELEEKLNDALH--QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
VD T EL + + + L + + +LA QQ+ A + + L E+E L +Q+
Sbjct: 1295 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLA--EVEAALEKQR 1351
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
QL E + Q + +A + L+ + +E+ ++ + D + +L
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1409
Query: 197 EI------------CELQVKKNILAEELSTN---------KNQLKQLTETYEEDRKNYSE 235
EI L++++ I L + +L+ L EE +
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA---------------LEQEVIE 280
Q +RL ++ D Q +Q + E +VK+E +A L+ E E
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527
Query: 281 LRRKHEILEASHMIQTK-ERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED 339
R + +E + +Q E ++ S E + + +K + L R E V A +
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLRE 1586
Query: 340 RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNAS 399
ER Q E+++AREE A R+ + + + +E ++RL+ + Q A
Sbjct: 1587 EAERRAQQQAEAERAREE------AERELERWQLK---ANEALRLRLQAEEVAQQKSLAQ 1637
Query: 400 REMYERENRNLREARDNAVAEKERAVMAE--KDALEKHDQLLDRYRELQLSTESKVTEFL 457
E +++ REAR AE++ E + LEK QL + + +L+ E ++
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL- 1696
Query: 458 HQSKLKSFESERVQLLQEETARNLTQCQLECEKYQK---KLEVLTKEFYSLQASSEKRIT 514
+++ + E +R QLL+EE AR + +K Q+ +L + E L AS +
Sbjct: 1697 -RAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
Query: 515 ELQAQNSEHQARLDI----YEKLEKE------LDEIIMQTAEIENED------EAERV-- 556
E ++ + + + RL+ + +L +E L E + ++ ED EAERV
Sbjct: 1755 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814
Query: 557 --LFSYGYGANVPTTAK-------------RRLKQSVHLARRVLQLEKQNSLILKDLEHR 601
L + G + T A+ RRL + RR +LE+Q + D+E R
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEER 1872
Query: 602 KDQVTQLS-QELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
Q+ + S EL+R L+ T + R + E + + + A+LE ++ +
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
Query: 661 KSALLQTKNQMALD 674
L++K Q L+
Sbjct: 1933 AEDTLRSKEQAELE 1946
Score = 75.1 bits (183), Expect = 2e-13
Identities = 113/592 (19%), Positives = 255/592 (43%), Gaps = 65/592 (10%)
Query: 179 IPEYVSVRFY---------ELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
I EYV +R + + + + + + ++ ++ + ++ + + +L ++ E+
Sbjct: 1291 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1350
Query: 230 RK---NYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
R+ +++ + + +R A EL Q ++ R+E + ++ ++++E+ +LR+ E
Sbjct: 1351 RQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1408
Query: 287 --ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERL 344
I + + ERS L +E+ + +++ E RQ E L+ L
Sbjct: 1409 AEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLEATERQR-------GGAEGELQAL 1456
Query: 345 QAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELE------------QIRLKTNQEI 392
+A+ EE++ + + E+ R + E + K E+E + + + Q +
Sbjct: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1516
Query: 393 DQLRNASREMYER-ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTES 451
++LR + E R + AR VA + AE + K ++ +L+ S +
Sbjct: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKL-EVLTKEFYSLQASSE 510
E + ++L+ E+ER Q E R + + E E++Q K E L + + + +
Sbjct: 1577 ---EHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1632
Query: 511 KRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTA 570
K + + +A+ + +A + + + E ++ + Q E E E +R L TA
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAE-EQAVRQRELAEQELEKQRQL--------AEGTA 1683
Query: 571 KRRL---KQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
++RL ++ + L Q E+Q L+ ++L + + +Q+ + L + +
Sbjct: 1684 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1743
Query: 628 YLIESVRQRDSKIDSLTESIAQ-LEKDVSNLNK--EKSALLQTKNQMALDLEQLLNH--R 682
L+ S + + + S +E Q LE + + E++A L+ + A QL
Sbjct: 1744 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1803
Query: 683 EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIF 734
+ A +++L + + E + L KTE + + ++++ + + ED F
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRL--KTEAEIALKEKEAENERLRRLAEDEAF 1853
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 108 bits (270), Expect = 2e-23
Identities = 143/713 (20%), Positives = 297/713 (41%), Gaps = 85/713 (11%)
Query: 13 NISSSLESEDISLETTVPTDDISSSEER---EGKVRITRQLI-------ERKELLHNIQL 62
N +L S++ + +++ EER E + R+ + L +RK L ++
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQE 122
LK ++ + + + + + +++ +E QK+L + A QQK+ Q
Sbjct: 2000 LKAKVEEARRLRERAEQESARQLQLAQEAA-----QKRLQAEEKAHAFAVQQKEQELQQT 2054
Query: 123 LMKQ---------EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFP 173
L ++ E E ++ EE +Q +A RR + + E +LK
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSA 2107
Query: 174 EDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
E+Q + LRKE E + + AE+ + + KQ + E K +
Sbjct: 2108 EEQAQ----ARAQAQAAAEKLRKE-AEQEAARRAQAEQAALRQ---KQAADAEMEKHKKF 2159
Query: 234 SEVQIRCQ-RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASH 292
+E +R + ++ EL + +++ D+++ D+ E L+ E E R+ +E
Sbjct: 2160 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEEL 2216
Query: 293 MIQTKERSELSKEVVTLE-QTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEES 351
+ ELSK +E + L+ +DK+ R E + + + RL +E+
Sbjct: 2217 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLR 411
+ R+ E R + + K+ E RLK E+ Q + +E+ + + R L+
Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQ 2333
Query: 412 EARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ 471
E ++ + + LE +R R+L++S E++ + KL+ E R Q
Sbjct: 2334 EDKEQMAQQLAEETQGFQRTLEA-----ERQRQLEMSAEAE------RLKLRVAEMSRAQ 2382
Query: 472 LLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT-----ELQAQNSEHQAR 526
EE A ++++K+ E + ++ + + ++++++T E+Q Q S+H A
Sbjct: 2383 ARAEEDA----------QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2432
Query: 527 L--DIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRV 584
+ +LE+E +++ + ++ + E + + + L + L +R
Sbjct: 2433 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2492
Query: 585 LQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDS-- 642
+E++ + + + + + QL +E R + Q +Q +E R+R + +
Sbjct: 2493 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Query: 643 --LTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLL--NHREELAAMKQI 691
E + QLE+ +++ LL +NQ + QLL HR LA +++
Sbjct: 2553 RRKQEELQQLEQQ----RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2601
Score = 90.9 bits (224), Expect = 4e-18
Identities = 155/737 (21%), Positives = 297/737 (40%), Gaps = 82/737 (11%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+ +LE+ S E + + S +E+ ++ R L E + ++ +Q+
Sbjct: 1549 VQVALETAQRSAEAELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAE 1605
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ-ELMKQEMETIL 132
+ + + ++E + K N+AL LRL + QQK ++ + E K+E E
Sbjct: 1606 AERAREEAERELERWQLKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1659
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFE--------LTEEQYIKLKAFPEDQLSIPEYVS 184
R+ + EE ++ RE A R E++ I+L+A E E
Sbjct: 1660 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQR 1715
Query: 185 VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY---EEDRKNYSEVQIRCQ 241
E + L++E K+ L EL+ + +++ L + EE+ ++ SE Q
Sbjct: 1716 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--Q 1773
Query: 242 RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSE 301
RL E ++L ++ + ++ K +R E++ R + E + A + E +
Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1833
Query: 302 LS-------KEVVTLEQTVTLLQKDKEYLNRQ--------NMELSVRCAH----EEDRLE 342
L KE + + L +D+ + R+ ++ R A + LE
Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1893
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRN----- 397
R + +E++ + R ++ E+ +A + ++ K ELE R+++N E D LR+
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE-DTLRSKEQAE 1952
Query: 398 ----ASREMYERENRNLREARD---NAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE 450
R++ E R REA + ++A +E A K ALE+ ++L + E + E
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012
Query: 451 SKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECE------KYQKKLEVLTKEFYS 504
E Q +L E+ + +L EE A Q E E + Q L+ L E +
Sbjct: 2013 RAEQESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2071
Query: 505 L-QASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYG 563
+A+ E +QA+ Q+R + E E + Q+AE + + A+ +
Sbjct: 2072 ARRAAEEAEEARVQAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLR 2125
Query: 564 ANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQ 623
A RR + R+ + + K E Q Q+ QEL L +T
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185
Query: 624 QPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNH-- 681
L E +++ ++ +Q+E+++ ++ + L + K ++ + L+
Sbjct: 2186 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2245
Query: 682 -------REELAAMKQI 691
+EE MKQ+
Sbjct: 2246 DNTQRFLQEEAEKMKQV 2262
Score = 89.4 bits (220), Expect = 1e-17
Identities = 151/674 (22%), Positives = 276/674 (40%), Gaps = 100/674 (14%)
Query: 79 VDYLTKIEELEEKLNDALH--QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
VD T EL + + + L + + +LA QQ+ A + + L E+E L +Q+
Sbjct: 1303 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLA--EVEAALEKQR 1359
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
QL E + Q + +A + L+ + +E+ ++ + D + +L
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1417
Query: 197 EI------------CELQVKKNILAEELSTN---------KNQLKQLTETYEEDRKNYSE 235
EI L++++ I L + +L+ L EE +
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA---------------LEQEVIE 280
Q +RL ++ D Q +Q + E +VK+E +A L+ E E
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535
Query: 281 LRRKHEILEASHMIQTK-ERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED 339
R + +E + +Q E ++ S E + + +K + L R E V A +
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLRE 1594
Query: 340 RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNAS 399
ER Q E+++AREE A R+ + + + +E ++RL+ + Q A
Sbjct: 1595 EAERRAQQQAEAERAREE------AERELERWQLK---ANEALRLRLQAEEVAQQKSLAQ 1645
Query: 400 REMYERENRNLREARDNAVAEKERAVMAE--KDALEKHDQLLDRYRELQLSTESKVTEFL 457
E +++ REAR AE++ E + LEK QL + + +L+ E ++
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL- 1704
Query: 458 HQSKLKSFESERVQLLQEETARNLTQCQLECEKYQK---KLEVLTKEFYSLQASSEKRIT 514
+++ + E +R QLL+EE AR + +K Q+ +L + E L AS +
Sbjct: 1705 -RAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762
Query: 515 ELQAQNSEHQARLDI----YEKLEKE------LDEIIMQTAEIENED------EAERV-- 556
E ++ + + + RL+ + +L +E L E + ++ ED EAERV
Sbjct: 1763 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1822
Query: 557 --LFSYGYGANVPTTAK-------------RRLKQSVHLARRVLQLEKQNSLILKDLEHR 601
L + G + T A+ RRL + RR +LE+Q + D+E R
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEER 1880
Query: 602 KDQVTQLS-QELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
Q+ + S EL+R L+ T + R + E + + + A+LE ++ +
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1940
Query: 661 KSALLQTKNQMALD 674
L++K Q L+
Sbjct: 1941 AEDTLRSKEQAELE 1954
Score = 75.1 bits (183), Expect = 2e-13
Identities = 113/592 (19%), Positives = 255/592 (43%), Gaps = 65/592 (10%)
Query: 179 IPEYVSVRFY---------ELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
I EYV +R + + + + + + ++ ++ + ++ + + +L ++ E+
Sbjct: 1299 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1358
Query: 230 RK---NYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
R+ +++ + + +R A EL Q ++ R+E + ++ ++++E+ +LR+ E
Sbjct: 1359 RQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1416
Query: 287 --ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERL 344
I + + ERS L +E+ + +++ E RQ E L+ L
Sbjct: 1417 AEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLEATERQR-------GGAEGELQAL 1464
Query: 345 QAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELE------------QIRLKTNQEI 392
+A+ EE++ + + E+ R + E + K E+E + + + Q +
Sbjct: 1465 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1524
Query: 393 DQLRNASREMYER-ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTES 451
++LR + E R + AR VA + AE + K ++ +L+ S +
Sbjct: 1525 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKL-EVLTKEFYSLQASSE 510
E + ++L+ E+ER Q E R + + E E++Q K E L + + + +
Sbjct: 1585 ---EHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1640
Query: 511 KRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTA 570
K + + +A+ + +A + + + E ++ + Q E E E +R L TA
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAE-EQAVRQRELAEQELEKQRQL--------AEGTA 1691
Query: 571 KRRL---KQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
++RL ++ + L Q E+Q L+ ++L + + +Q+ + L + +
Sbjct: 1692 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1751
Query: 628 YLIESVRQRDSKIDSLTESIAQ-LEKDVSNLNK--EKSALLQTKNQMALDLEQLLNH--R 682
L+ S + + + S +E Q LE + + E++A L+ + A QL
Sbjct: 1752 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1811
Query: 683 EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIF 734
+ A +++L + + E + L KTE + + ++++ + + ED F
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRL--KTEAEIALKEKEAENERLRRLAEDEAF 1861
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 108 bits (270), Expect = 2e-23
Identities = 143/713 (20%), Positives = 297/713 (41%), Gaps = 85/713 (11%)
Query: 13 NISSSLESEDISLETTVPTDDISSSEER---EGKVRITRQLI-------ERKELLHNIQL 62
N +L S++ + +++ EER E + R+ + L +RK L ++
Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQE 122
LK ++ + + + + + +++ +E QK+L + A QQK+ Q
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAA-----QKRLQAEEKAHAFAVQQKEQELQQT 2095
Query: 123 LMKQ---------EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFP 173
L ++ E E ++ EE +Q +A RR + + E +LK
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSA 2148
Query: 174 EDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
E+Q + LRKE E + + AE+ + + KQ + E K +
Sbjct: 2149 EEQAQ----ARAQAQAAAEKLRKE-AEQEAARRAQAEQAALRQ---KQAADAEMEKHKKF 2200
Query: 234 SEVQIRCQ-RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASH 292
+E +R + ++ EL + +++ D+++ D+ E L+ E E R+ +E
Sbjct: 2201 AEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEEL 2257
Query: 293 MIQTKERSELSKEVVTLE-QTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEES 351
+ ELSK +E + L+ +DK+ R E + + + RL +E+
Sbjct: 2258 FSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLR 411
+ R+ E R + + K+ E RLK E+ Q + +E+ + + R L+
Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---KELAQEQARRLQ 2374
Query: 412 EARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ 471
E ++ + + LE +R R+L++S E++ + KL+ E R Q
Sbjct: 2375 EDKEQMAQQLAEETQGFQRTLEA-----ERQRQLEMSAEAE------RLKLRVAEMSRAQ 2423
Query: 472 LLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT-----ELQAQNSEHQAR 526
EE A ++++K+ E + ++ + + ++++++T E+Q Q S+H A
Sbjct: 2424 ARAEEDA----------QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2473
Query: 527 L--DIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRV 584
+ +LE+E +++ + ++ + E + + + L + L +R
Sbjct: 2474 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2533
Query: 585 LQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDS-- 642
+E++ + + + + + QL +E R + Q +Q +E R+R + +
Sbjct: 2534 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Query: 643 --LTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLL--NHREELAAMKQI 691
E + QLE+ +++ LL +NQ + QLL HR LA +++
Sbjct: 2594 RRKQEELQQLEQQ----RRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEV 2642
Score = 90.9 bits (224), Expect = 4e-18
Identities = 155/737 (21%), Positives = 297/737 (40%), Gaps = 82/737 (11%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+ +LE+ S E + + S +E+ ++ R L E + ++ +Q+
Sbjct: 1590 VQVALETAQRSAEAELQSKRASFAEKT---AQLERSLQEEHVAVAQLREEAERRAQQQAE 1646
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ-ELMKQEMETIL 132
+ + + ++E + K N+AL LRL + QQK ++ + E K+E E
Sbjct: 1647 AERAREEAERELERWQLKANEALR------LRLQAEEVAQQKSLAQAEAEKQKEEAEREA 1700
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFE--------LTEEQYIKLKAFPEDQLSIPEYVS 184
R+ + EE ++ RE A R E++ I+L+A E E
Sbjct: 1701 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQR 1756
Query: 185 VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY---EEDRKNYSEVQIRCQ 241
E + L++E K+ L EL+ + +++ L + EE+ ++ SE Q
Sbjct: 1757 QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--Q 1814
Query: 242 RLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSE 301
RL E ++L ++ + ++ K +R E++ R + E + A + E +
Sbjct: 1815 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1874
Query: 302 LS-------KEVVTLEQTVTLLQKDKEYLNRQ--------NMELSVRCAH----EEDRLE 342
L KE + + L +D+ + R+ ++ R A + LE
Sbjct: 1875 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1934
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRN----- 397
R + +E++ + R ++ E+ +A + ++ K ELE R+++N E D LR+
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE-DTLRSKEQAE 1993
Query: 398 ----ASREMYERENRNLREARD---NAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE 450
R++ E R REA + ++A +E A K ALE+ ++L + E + E
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053
Query: 451 SKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECE------KYQKKLEVLTKEFYS 504
E Q +L E+ + +L EE A Q E E + Q L+ L E +
Sbjct: 2054 RAEQESARQLQLAQ-EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA 2112
Query: 505 L-QASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYG 563
+A+ E +QA+ Q+R + E E + Q+AE + + A+ +
Sbjct: 2113 ARRAAEEAEEARVQAEREAAQSRRQVEEA------ERLKQSAEEQAQARAQAQAAAEKLR 2166
Query: 564 ANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQ 623
A RR + R+ + + K E Q Q+ QEL L +T
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226
Query: 624 QPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNH-- 681
L E +++ ++ +Q+E+++ ++ + L + K ++ + L+
Sbjct: 2227 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDK 2286
Query: 682 -------REELAAMKQI 691
+EE MKQ+
Sbjct: 2287 DNTQRFLQEEAEKMKQV 2303
Score = 89.4 bits (220), Expect = 1e-17
Identities = 151/674 (22%), Positives = 276/674 (40%), Gaps = 100/674 (14%)
Query: 79 VDYLTKIEELEEKLNDALH--QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQK 136
VD T EL + + + L + + +LA QQ+ A + + L E+E L +Q+
Sbjct: 1344 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQR-AEERERLA--EVEAALEKQR 1400
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRK 196
QL E + Q + +A + L+ + +E+ ++ + D + +L
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQ--QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1458
Query: 197 EI------------CELQVKKNILAEELSTN---------KNQLKQLTETYEEDRKNYSE 235
EI L++++ I L + +L+ L EE +
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA---------------LEQEVIE 280
Q +RL ++ D Q +Q + E +VK+E +A L+ E E
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEV--ELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576
Query: 281 LRRKHEILEASHMIQTK-ERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED 339
R + +E + +Q E ++ S E + + +K + L R E V A +
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ-LERSLQEEHVAVAQLRE 1635
Query: 340 RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNAS 399
ER Q E+++AREE A R+ + + + +E ++RL+ + Q A
Sbjct: 1636 EAERRAQQQAEAERAREE------AERELERWQLK---ANEALRLRLQAEEVAQQKSLAQ 1686
Query: 400 REMYERENRNLREARDNAVAEKERAVMAE--KDALEKHDQLLDRYRELQLSTESKVTEFL 457
E +++ REAR AE++ E + LEK QL + + +L+ E ++
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL- 1745
Query: 458 HQSKLKSFESERVQLLQEETARNLTQCQLECEKYQK---KLEVLTKEFYSLQASSEKRIT 514
+++ + E +R QLL+EE AR + +K Q+ +L + E L AS +
Sbjct: 1746 -RAETEQGEQQR-QLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803
Query: 515 ELQAQNSEHQARLDI----YEKLEKE------LDEIIMQTAEIENED------EAERV-- 556
E ++ + + + RL+ + +L +E L E + ++ ED EAERV
Sbjct: 1804 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1863
Query: 557 --LFSYGYGANVPTTAK-------------RRLKQSVHLARRVLQLEKQNSLILKDLEHR 601
L + G + T A+ RRL + RR +LE+Q + D+E R
Sbjct: 1864 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEER 1921
Query: 602 KDQVTQLS-QELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE 660
Q+ + S EL+R L+ T + R + E + + + A+LE ++ +
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
Query: 661 KSALLQTKNQMALD 674
L++K Q L+
Sbjct: 1982 AEDTLRSKEQAELE 1995
Score = 75.1 bits (183), Expect = 2e-13
Identities = 113/592 (19%), Positives = 255/592 (43%), Gaps = 65/592 (10%)
Query: 179 IPEYVSVRFY---------ELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
I EYV +R + + + + + + ++ ++ + ++ + + +L ++ E+
Sbjct: 1340 IQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1399
Query: 230 RK---NYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
R+ +++ + + +R A EL Q ++ R+E + ++ ++++E+ +LR+ E
Sbjct: 1400 RQLAEAHAQAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457
Query: 287 --ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERL 344
I + + ERS L +E+ + +++ E RQ E L+ L
Sbjct: 1458 AEIQAKARQAEAAERSRLR-----IEEEIRVVRLQLEATERQR-------GGAEGELQAL 1505
Query: 345 QAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELE------------QIRLKTNQEI 392
+A+ EE++ + + E+ R + E + K E+E + + + Q +
Sbjct: 1506 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1565
Query: 393 DQLRNASREMYER-ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTES 451
++LR + E R + AR VA + AE + K ++ +L+ S +
Sbjct: 1566 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKL-EVLTKEFYSLQASSE 510
E + ++L+ E+ER Q E R + + E E++Q K E L + + + +
Sbjct: 1626 ---EHVAVAQLRE-EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQ 1681
Query: 511 KRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTA 570
K + + +A+ + +A + + + E ++ + Q E E E +R L TA
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAE-EQAVRQRELAEQELEKQRQL--------AEGTA 1732
Query: 571 KRRL---KQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
++RL ++ + L Q E+Q L+ ++L + + +Q+ + L + +
Sbjct: 1733 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1792
Query: 628 YLIESVRQRDSKIDSLTESIAQ-LEKDVSNLNK--EKSALLQTKNQMALDLEQLLNH--R 682
L+ S + + + S +E Q LE + + E++A L+ + A QL
Sbjct: 1793 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1852
Query: 683 EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIF 734
+ A +++L + + E + L KTE + + ++++ + + ED F
Sbjct: 1853 RQRAEAERVLAEKLAAIGEATRL--KTEAEIALKEKEAENERLRRLAEDEAF 1902
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 105 bits (263), Expect = 1e-22
Identities = 146/742 (19%), Positives = 314/742 (42%), Gaps = 93/742 (12%)
Query: 37 SEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDAL 96
+E E + R+ + E +E+LH+++ E ++ ++ N K I++LEE+L++
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 97 HQKQLLTL----------RLDNQLAFQQKDASKY---QELMKQ---EMETILLRQKQLEE 140
+Q L L +++ ++ + SK+ ++LM+ E + L +++ +
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 141 TNLQLREK----AGDVRRNLRDFELTEEQYIKLK-------AFPEDQLSIPEYVSVRFYE 189
++R K D+ L+ E T ++ K K +DQ++ + + E
Sbjct: 1024 NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA---ELQAQIDE 1080
Query: 190 LVNPLRKEICELQ----------VKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIR 239
L L K+ ELQ + KN + + + Q+ +L E +E ++ + ++ + +
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 240 CQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKER 299
+ L+ EL K ++ +++++R EQEV EL++ E +H Q ++
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKR---EQEVAELKKALEEETKNHEAQIQDM 1197
Query: 300 --------SELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEES 351
ELS+++ ++ L+K+K+ L N EL A E L++++A+ E
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKEL----ACEVKVLQQVKAESEHK 1253
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLR 411
+K + ++ H K ++L EL + K E+D N S + E E + ++
Sbjct: 1254 RKKLDAQVQEL-----HAKVSEGDRLRVELAEKASKLQNELD---NVSTLLEEAEKKGIK 1305
Query: 412 EARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ 471
A+D A E + L+ +LL +L+ S++ + + + E +
Sbjct: 1306 FAKDAASLESQ---------LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356
Query: 472 LLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYE 531
++ + + Q + +KK++ SL+ + +K + + +A + + + Y+
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416
Query: 532 KLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQN 591
KLEK + + + E + + + V + +++ K+ L L ++
Sbjct: 1417 KLEKTKNRL---------QQELDDLTVDLDHQRQVASNLEKKQKKFDQL------LAEEK 1461
Query: 592 SLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRD---SKIDSLTESIA 648
S+ + E R + ++ +A SL ++ E RQ + ++ L S
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 649 QLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTK 708
+ K+V L K K AL Q +M LE+L +EL A + +++ +
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEEL---EDELQATEDAKLRLEVNMQAMKAQFER 1578
Query: 709 TEPKHVTENQKSKTLNVPKEHE 730
+N++ K L + + E
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRE 1600
Score = 105 bits (261), Expect = 2e-22
Identities = 149/679 (21%), Positives = 285/679 (41%), Gaps = 72/679 (10%)
Query: 15 SSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMI 74
+S L++E ++ T + + + + + QL + +ELL K+ LS + +
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 75 DNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDAS---------------- 118
+ K ++E +E+ +A + L L +QLA +K
Sbjct: 1342 EEEK----NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 119 -KYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQL 177
K E + Q +E L +LE+T +L+++ D+ +L D + ++ K DQL
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL-DHQRQVASNLEKKQKKFDQL 1456
Query: 178 SIPEY-VSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEV 236
E +S R+ E + E E + K LA L + + E +E K
Sbjct: 1457 LAEEKSISARYAEERDRAEAEAREKETKALSLARALE----EALEAKEEFERQNK----- 1507
Query: 237 QIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQT 296
Q+R AD + L+ D +N +++ + ALEQ+V E+R + E LE +Q
Sbjct: 1508 QLR--------ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE--LQA 1557
Query: 297 KERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKARE 356
E ++L EV ++ ++D + + QN E + + L+A+LE+ +K R
Sbjct: 1558 TEDAKLRLEV-NMQAMKAQFERDLQTRDEQNEEKKRLLIKQ---VRELEAELEDERKQRA 1613
Query: 357 EMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREM--YERENRNLREAR 414
VAS+ + + ++ L ++E ++ I QLR +M Y+RE R +R
Sbjct: 1614 LA----VASKKKMEIDLKD-LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASR 1668
Query: 415 DNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLK----SFESERV 470
D A+ + + EK ++L EL S ++ + +L + S +
Sbjct: 1669 DEIFAQSKES---EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKS 1725
Query: 471 QLLQEETA--RNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLD 528
LL E+ + Q + E E+ Q +E+L F + EL A+ S Q +
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDN 1785
Query: 529 IYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANV---PTTAKRRLKQSVHLARRVL 585
++LE++ E+ + E+E +++ A + ++ K+ + V
Sbjct: 1786 ARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR 1845
Query: 586 QLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIE-------SVRQRDS 638
+ EK+ I +E + Q +++++AN+ + Q ++ E S R+
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQR 1905
Query: 639 KIDSLTESIAQLEKDVSNL 657
++D TE+ L ++VS L
Sbjct: 1906 ELDDATEANEGLSREVSTL 1924
Score = 101 bits (252), Expect = 2e-21
Identities = 155/767 (20%), Positives = 324/767 (42%), Gaps = 87/767 (11%)
Query: 2 SRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIER--KELLHN 59
S+ +E K N++ +++ IS EER K TRQ +E+ ++L
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVM---------ISDLEERLKKEEKTRQELEKAKRKLDGE 1063
Query: 60 IQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASK 119
L+ ++++ ID LK+ K EE+L AL + TL +N L ++ ++
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKK----EEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 120 YQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSI 179
EL +++ E+ + + E+ L E+ ++ L D T +L+ E +++
Sbjct: 1120 IAEL-QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVA- 1177
Query: 180 PEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIR 239
+ E +I +++ + EELS Q K+ E KN ++
Sbjct: 1178 --ELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE---KNKQGLETD 1232
Query: 240 CQRLALELADTKQLIQQGDYRQENYD--------KVKSERDALEQEVIELRRK--HEILE 289
+ LA E+ +Q+ + +++++ D KV SE D L E+ E K +E+
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKV-SEGDRLRVELAEKASKLQNELDN 1291
Query: 290 ASHMIQTKERS--ELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQ 347
S +++ E+ + +K+ +LE + Q+ + RQ + LS R E+ LQ Q
Sbjct: 1292 VSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ 1351
Query: 348 LEESKKAREEMYEKYVASRDHYKTEYENKLHDEL------EQIRLKT-------NQEIDQ 394
EE ++AR+ + EK V + + + K+ D+L E+ + K +Q +++
Sbjct: 1352 QEEEEEARKNL-EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 395 LRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVT 454
A ++ + +NR +E D V + +A LEK + D+ + S ++
Sbjct: 1411 KALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN--LEKKQKKFDQLLAEEKSISARYA 1468
Query: 455 EFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT 514
E +++ ++ E E L + + E E+ K+L ++ S + K +
Sbjct: 1469 EERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH 1528
Query: 515 ELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRL 574
EL+ + +++ +EL++ + T + + E + ++ T ++
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588
Query: 575 KQSVHLARRVLQLE-----------------KQNSLILKDLEHRKDQVTQLSQELDRANS 617
++ L ++V +LE K+ + LKDLE + + + E+ +
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLR 1648
Query: 618 LLNQTQQPYRYLIESVR-----------QRDSKIDSLTESIAQLEKDVSNLNKEKSALLQ 666
L + Y+ +E R + + K+ SL I QL++++++ + + Q
Sbjct: 1649 KLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ 1708
Query: 667 TKNQMALDL-------EQLLNHREEL-AAMKQILVKMHSKHSENSLL 705
++++A ++ LL+ + L A + Q+ ++ + S LL
Sbjct: 1709 ERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Score = 93.6 bits (231), Expect = 6e-19
Identities = 129/611 (21%), Positives = 262/611 (42%), Gaps = 86/611 (14%)
Query: 139 EETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLS-----IPEYVSVR------- 186
+E L+++EK V L + E +Q ++ K +QL E +R
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 187 --FYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLA 244
E+++ L + E + + IL E + ++ L E +E+ ++Q+ +++
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL--EKVT 975
Query: 245 LELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSK 304
E A K++ ++ ++ K E+ +E + E + E K R++
Sbjct: 976 AE-AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEV 1034
Query: 305 EVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESK---KAREEMYEK 361
+ LE+ + +K ++ L + +L +D++ LQAQ++E K +EE +
Sbjct: 1035 MISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQG 1094
Query: 362 YVASRDHYKTEYENKLHDELE-QIRLKTNQEIDQLRNASREMYERENRNLRE-------- 412
+A D N L E Q ++ QE + ASR E++ R+L E
Sbjct: 1095 ALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTE 1154
Query: 413 ---------ARDNAVAEKERAVMAEKDALEK----HDQLLDRYRELQLSTESKVTEFLHQ 459
A+ ++E+ V K ALE+ H+ + R+ + +++E L Q
Sbjct: 1155 LEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQ 1214
Query: 460 SK---------LKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSE 510
+K + E++ +L E + L Q + E E +KKL+ +E ++ + +
Sbjct: 1215 AKRFKANLEKNKQGLETDNKELACE--VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1272
Query: 511 KRITELQAQNSEHQARLD----IYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANV 566
+ EL + S+ Q LD + E+ EK+ + A +E++ + + L
Sbjct: 1273 RLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL-------- 1324
Query: 567 PTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPY 626
+ +Q ++L+ R+ QLE++ + + + E ++ L +++ S L T+
Sbjct: 1325 ----QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK--- 1377
Query: 627 RYLIESVRQRDSKIDSLTESIAQLEKDVSNLNK--EKSALL-----QTKNQMALDLEQL- 678
+ V I+SL E+ +L KD L++ E+ AL +TKN++ +L+ L
Sbjct: 1378 ----KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433
Query: 679 --LNHREELAA 687
L+H+ ++A+
Sbjct: 1434 VDLDHQRQVAS 1444
Score = 67.4 bits (163), Expect = 5e-11
Identities = 104/477 (21%), Positives = 204/477 (42%), Gaps = 76/477 (15%)
Query: 260 RQENYDKVKSERDALEQEVIELRRKH-EILEASHMI--QTKERSELSKEVVTLEQTVTLL 316
+ E KVK ++ +E E+ E+ RKH ++LE +++ Q + +EL E E+ L
Sbjct: 857 KDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA---EEMRARL 913
Query: 317 QKDKEYLNRQNMELSVRCAHEEDR--------------LERLQAQLEESKKAREEM-YEK 361
K+ L +L R EE+R ++ L+ QL+E + AR+++ EK
Sbjct: 914 AAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEK 973
Query: 362 YVASRDHYKTEYENKLHDELEQIRLKTNQEI-DQLRNASREMYERENRNLREARDNAVAE 420
A K E E L ++ +K + + D++ S ++ E E + A+ +
Sbjct: 974 VTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAK---IRN 1030
Query: 421 KERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARN 480
K+ ++++ E +L E K + L ++K K + E LQ++ A
Sbjct: 1031 KQEVMISD--------------LEERLKKEEKTRQELEKAKRK-LDGETTD-LQDQIA-- 1072
Query: 481 LTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEI 540
+L+ + + KL++ KE LQ + + E +N+ K + E+
Sbjct: 1073 ----ELQAQIDELKLQLAKKE-EELQGALARGDDETLHKNN-----------ALKVVREL 1116
Query: 541 IMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEH 600
Q AE++ + E+E+ N KR L + + + L+ + ++L
Sbjct: 1117 QAQIAELQEDFESEKA------SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR- 1169
Query: 601 RKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRD-SKIDSLTESIAQLEKDVSNLNK 659
T+ QE+ L + + + I+ +RQR + ++ L+E + Q ++ +NL K
Sbjct: 1170 -----TKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Query: 660 EKSALLQTKNQMALDLEQLLNHREELAAMKQIL----VKMHSKHSENSLLLTKTEPK 712
K L ++A +++ L + E ++ L ++H+K SE L + K
Sbjct: 1225 NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1281
Score = 42.0 bits (97), Expect = 0.002
Identities = 55/237 (23%), Positives = 101/237 (42%), Gaps = 25/237 (10%)
Query: 486 LECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTA 545
L+ + +++L+ +E ++ K EL+ +HQ L+ L ++L A
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ------A 898
Query: 546 EIENEDEAERVLFSYGYGANVPTTAKRRLKQSVH-LARRVLQLEKQNSLILKDLEHRKDQ 604
E E EAE + K+ L++ +H L RV + E++N ++ + + +
Sbjct: 899 ETELFAEAEEMRARL-------AAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951
Query: 605 VTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSAL 664
+ L ++LD + Q +E V ++KI + E I LE S KEK +
Sbjct: 952 IQDLEEQLDEEEGARQKLQ------LEKV-TAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004
Query: 665 LQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSK 721
++++A QL E+ + +I K S+ L K E K E +K+K
Sbjct: 1005 ---EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL-KKEEKTRQELEKAK 1057
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 105 bits (262), Expect = 2e-22
Identities = 168/723 (23%), Positives = 320/723 (44%), Gaps = 80/723 (11%)
Query: 46 ITRQLIERKELLHNIQLLKIELSQKTMMI-------DNLKVDYLTKIEELEEKLNDALHQ 98
+ + +E +HN+QL E S + + + D L +++EL+ KL+ L +
Sbjct: 1758 VPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLH--LQE 1815
Query: 99 KQLLTL--------RLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQL----- 145
QL+T ++ +L + D S+ E + + +L R + E N L
Sbjct: 1816 VQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHAD 1875
Query: 146 ---REKAGDVRRNLRDFELTEEQYIKLKAFPEDQLS--IPEYVSVRFYELVNPLRKEICE 200
RE GD + D +E+++ + E++LS E S+ L L ++
Sbjct: 1876 KSSREDIGDNVAKVND--SWKERFLDV----ENELSRIRSEKASIEHEALY--LEADLEV 1927
Query: 201 LQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYR 260
+Q +K L ++ N+N+ K + EE S V +L EL + D
Sbjct: 1928 VQTEKLCLEKD---NENKQKVIVCLEEE----LSVVTSERNQLRGELDTMSKKTTALDQL 1980
Query: 261 QENYDKVKSERDALEQEVIELRR--KHEILEASHMIQT--KERSELSKEVVTLEQTVTLL 316
E + E ++ + E + + + E+ E + ++QT + SEL K+ L++ + L
Sbjct: 1981 SEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSL 2040
Query: 317 QKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAR--EEMYEKYVASRDHYKTEYE 374
+KD + L+ EL + A + ++ + L + ES +AR E YEK S+ E
Sbjct: 2041 EKDSQALSLTKCELENQIA-QLNKEKELLVKESESLQARLSESDYEKLNVSK-----ALE 2094
Query: 375 NKLHDELE-QIRL-KTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDAL 432
L ++ E +RL T +E+ QLR ++ R + E + +AEK + E D+L
Sbjct: 2095 AALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEAD--EKKQLHIAEKLKERERENDSL 2152
Query: 433 EKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQ 492
+ D++ + RELQ+S E++ L K+ E E ++ EE AR+L +L+ +
Sbjct: 2153 K--DKVENLERELQMSEENQELVILDAENSKA-EVETLKTQIEEMARSLKVFELDLVTLR 2209
Query: 493 KKLEVLTKEFYSLQ---ASSEKRITELQAQNSE-HQARLDIYEKLEKELDEIIMQTAEIE 548
+ E LTK+ Q + +K ++ ++ E QA + I E+ + ++ + Q E+
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELN 2269
Query: 549 NEDEA----ERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLI----LKDLEH 600
A + ++ + + P + +L+ S+ R L+ +++ L LK+ EH
Sbjct: 2270 EAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEH 2329
Query: 601 RKDQVTQLSQELDRANSLLNQTQQPYRYLIES----VRQRDSKIDSLTESIAQLEKDVSN 656
D + + L+R + Q+ E+ V +KI+ +T+S+ LE DV
Sbjct: 2330 HADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVT 2389
Query: 657 LNKEKSAL---LQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKH 713
+ EK L LQ + + +LE + + E + K+ + S ++ + +T+ K
Sbjct: 2390 IRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKE 2449
Query: 714 VTE 716
+ E
Sbjct: 2450 LNE 2452
Score = 100 bits (249), Expect = 5e-21
Identities = 177/817 (21%), Positives = 336/817 (41%), Gaps = 96/817 (11%)
Query: 2 SRKISKESKKVNISSSLESE-----DISLETTVPTDDISSSEEREGKVRITRQLIERKEL 56
+R + +K+N+S +LE+ + +L + +++ K+R+ + E+K+L
Sbjct: 2077 ARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQL 2136
Query: 57 LHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKD 116
H + LK ++ D+LK K+E LE +L + ++L+ L +N A +
Sbjct: 2137 -HIAEKLK----ERERENDSLK----DKVENLERELQMSEENQELVILDAENSKAEVETL 2187
Query: 117 ASKYQELMKQ----EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAF 172
++ +E+ + E++ + LR ++ E Q++EK G + ++ K+
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEK-ENLTKQIQEKQGQLSE-------LDKLLSSFKSL 2239
Query: 173 PEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKN 232
E++ + V L+ ++ EL L + K + L EE+ +
Sbjct: 2240 LEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQL 2299
Query: 233 YSEVQIRCQRLALELADTKQL--IQQGDYRQENYDKVKSERDALEQE--VIELRRKHEIL 288
+ ++ R LE + KQL +QQ + + D +K + LE+E + ++H L
Sbjct: 2300 RNSIEKL--RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAAL 2357
Query: 289 EASHMIQTKERSELSKEVVT-----LEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLER 343
EA + E + E +T LE V ++ +KE L + + R + E
Sbjct: 2358 EAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSS 2417
Query: 344 LQAQLEESKKAREEMYEKYVASRDHYKTEYEN------KLHDELEQIRLKTNQEIDQLRN 397
+ L+E ++ + +M EK + + +T+ + LH++ E + K Q+
Sbjct: 2418 FENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVEC 2477
Query: 398 ASREMYERENRNLREARDNAVAEKE------RAVMAEKDALEKHDQLLDRYRELQLSTES 451
E + + L EA++N + + + V K LEK D+ + R + E
Sbjct: 2478 LELEKAQLL-QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ 2536
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETA--RNLT-QCQLECEKYQKKLEVLTKEFYSLQAS 508
V SKL E E QL +E+ RNLT + + + + Q K L LQ+S
Sbjct: 2537 LV------SKLSQVEGEH-QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSS 2589
Query: 509 SEKRITELQAQNSEHQARLDIYEK-------LEKELDEIIMQTAEIENE--DEAERVLFS 559
+ EL+ + + ++ K L++E+ E+ +TAE++ E E R+
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
Query: 560 YGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQ--------LSQE 611
++K +LK+ L +L+K + KD ++ +V + L +
Sbjct: 2650 LQLLLEEIKSSKDQLKE---LTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEA 2706
Query: 612 LDRANSLLNQTQQPYRYLIESVRQRDS-----------KIDSLTESIAQLEKDVSNLNKE 660
+ +LL T + Y I++ R++ + +ID L S +L + +
Sbjct: 2707 EKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQI 2766
Query: 661 KSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKS 720
L +TK + QL E ++L+K + E +L K + +K
Sbjct: 2767 LEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
Query: 721 KTLNVPKEHEDNIFTP----KPTLFTK-KEAPEWSKK 752
KT V D + T K TL K KEA E+ K
Sbjct: 2827 KTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDK 2863
Score = 100 bits (248), Expect = 7e-21
Identities = 160/751 (21%), Positives = 308/751 (41%), Gaps = 91/751 (12%)
Query: 16 SSLESEDISLET---TVPTDDISSSEEREGKVRITRQLIERKELLHNIQ-LLKIEL---S 68
+S+E E + LE V T+ + ++ E K ++ L E ++ + + L+ EL S
Sbjct: 1912 ASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMS 1971
Query: 69 QKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEM 128
+KT +D L K +ELE ++ LH Q+ + + Q +S EL+K +
Sbjct: 1972 KKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKT 2031
Query: 129 ETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFY 188
+ + + LE+ + L ++ + +E +K + S+ +S Y
Sbjct: 2032 H-LQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVK------ESESLQARLSESDY 2084
Query: 189 ELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELA 248
E +N + K + V+K A LS+ + ++ QL R+ ++++R +E
Sbjct: 2085 EKLN-VSKALEAALVEKGEFALRLSSTQEEVHQL-------RRGIEKLRVR-----IEAD 2131
Query: 249 DTKQL--IQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEV 306
+ KQL ++ R+ D +K + + LE+E+ E++ E L ++
Sbjct: 2132 EKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQI 2191
Query: 307 VTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASR 366
+ +++ + + D L + L+ + ++ +L L L K EE + + +
Sbjct: 2192 EEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIK 2251
Query: 367 DHYKTEYENKLHDELEQIR-----LKTNQEIDQLRNASREMYERENRNLR------EARD 415
+ KT E L ++L+++ L +QEI + S + E LR AR
Sbjct: 2252 EESKTAVE-MLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARL 2310
Query: 416 NAVAEKERAVMAEKDALEKHDQLL-----DRYRELQLSTESKVTEFLHQSKLKSFESERV 470
A +K+ V+ + E H LL + REL+++ ++ L K E E +
Sbjct: 2311 EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKG-EVETL 2369
Query: 471 QLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIY 530
+ E ++L +L+ + + E LT E ++RI+EL+ NS + L
Sbjct: 2370 KAKIEGMTQSLRGLELDVVTIRSEKENLTNEL----QKEQERISELEIINSSFENILQEK 2425
Query: 531 EKLE---KELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQL 587
E+ + KE M+ + + ++ ERV ++H + +
Sbjct: 2426 EQEKVQMKEKSSTAMEMLQTQLKELNERV-------------------AALHNDQEACKA 2466
Query: 588 EKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESI 647
++QN + +E + + QL Q LD A + Q LI+ V K++ E I
Sbjct: 2467 KEQN--LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEI 2524
Query: 648 AQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHS------- 700
++L+ + + + S L Q + + L EQ L R ++Q + + SK++
Sbjct: 2525 SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLE 2584
Query: 701 ---------ENSLLLTKTEPKHVTENQKSKT 722
EN L LTK + E T
Sbjct: 2585 VLQSSYKNLENELELTKMDKMSFVEKVNKMT 2615
Score = 90.1 bits (222), Expect = 7e-18
Identities = 156/782 (19%), Positives = 325/782 (41%), Gaps = 94/782 (12%)
Query: 16 SSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKE-------LLHNIQLLKIE-- 66
SSL+ E+++ + T P+ EE E + RQ +E+ E ++ N ++ ++E
Sbjct: 1529 SSLQEENLTRKET-PSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQL 1587
Query: 67 LSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ---EL 123
LS + +D L+ YL++ E+ ++KL +TL ++++LA ++K + E+
Sbjct: 1588 LSSERQELDCLRKQYLSENEQWQQKLTS-------VTLEMESKLAAEKKQTEQLSLELEV 1640
Query: 124 MKQEMETILLRQKQL----EETNLQLREKAGDVRRNLRDFELTEE-------QYIKLKAF 172
+ +++ + L + L E +Q R ++ D+ + E TE Q A
Sbjct: 1641 ARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKE-HTSETTERTPKHDVHQICDKDAQ 1699
Query: 173 PEDQLSIPEYVSVRFYELVNPLRKEIC-----------ELQVKKNILAEELSTNKNQLKQ 221
+ L I + + E + Q ++E + N L
Sbjct: 1700 QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVP 1759
Query: 222 LTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIEL 281
+ + ++++ +Q+R + + E +I+ D + E+ L E+ EL
Sbjct: 1760 MD--FLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVES----------LLNEMKEL 1807
Query: 282 RRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRL 341
K + E M + + EL K V L++ + L + EY + + EL R E
Sbjct: 1808 DSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLN 1867
Query: 342 ERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRL-KTNQEIDQLR-NAS 399
L+ + K +RE++ + D +K + + + +EL +IR K + E + L A
Sbjct: 1868 SDLE--MHADKSSREDIGDNVAKVNDSWKERFLD-VENELSRIRSEKASIEHEALYLEAD 1924
Query: 400 REMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQ 459
E+ + E L + +N K++ ++ ++ L ++ R +L T SK T L Q
Sbjct: 1925 LEVVQTEKLCLEKDNEN----KQKVIVCLEEELSVVTSERNQLRG-ELDTMSKKTTALDQ 1979
Query: 460 SKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQ 519
K +E + L Q EC + E KE L + ++EL
Sbjct: 1980 LSEK----------MKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKD 2029
Query: 520 NSEHQARLDIYEKLEKELDEIIMQTAEIENE----DEAERVLFSYGYGANVPTTAKRRLK 575
+ Q +L + LEK+ + + E+EN+ ++ + +L + K
Sbjct: 2030 KTHLQEKL---QSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEK 2086
Query: 576 QSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQ 635
+V A +EK + L +++V QL + +++ + ++ ++ E +++
Sbjct: 2087 LNVSKALEAALVEKGEFALR--LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKE 2144
Query: 636 RDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKM 695
R+ + DSL + + LE+++ + + ++ ++E L EE+A ++
Sbjct: 2145 RERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF--- 2201
Query: 696 HSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQKM 755
E L+ ++E +++T+ + K + D + + +L +KE E K++
Sbjct: 2202 -----ELDLVTLRSEKENLTKQIQEKQGQL--SELDKLLSSFKSLLEEKEQAEIQIKEES 2254
Query: 756 KT 757
KT
Sbjct: 2255 KT 2256
Score = 84.0 bits (206), Expect = 5e-16
Identities = 153/674 (22%), Positives = 284/674 (42%), Gaps = 90/674 (13%)
Query: 75 DNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLR 134
+ L L KI+ELE +L+ +KQ +LD+ A QK KQ++E
Sbjct: 10 EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQK--------QKQKVE----- 56
Query: 135 QKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYE-LVNP 193
++ E TNL+ R N R E+ E K K +L + E V F E +N
Sbjct: 57 NEKTEGTNLK--------RENQRLMEIC-ESLEKTKQKISHELQVKE-SQVNFQEGQLNS 106
Query: 194 LRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQL 253
+K+I +L+ +EL K++L++ + + + + Q++ Q
Sbjct: 107 GKKQIEKLE-------QELKRCKSELERSQQAAQSADVSLNPCNTP-QKIFTTPLTPSQY 158
Query: 254 IQQGDYR--QENYDKVKSERDALEQEVIELRRK---HEILEASHMIQTKERSELSKEVVT 308
Y +E Y+K ER LE EV L+ K + +A+ + R + S V +
Sbjct: 159 YSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFS 218
Query: 309 LEQTVT---LLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVAS 365
+Q T L + R++ S +E R Q+ + + A ++ +S
Sbjct: 219 WQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGK-RDANSSFFDN--SS 275
Query: 366 RDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENR------NLREARDNAVA 419
H ++L + +++R K N+ +L+ +EM + N+ L +A+ +
Sbjct: 276 SPHLL----DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELI- 330
Query: 420 EKERAVMAEKDAL----EKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQE 475
EKE+ + +D L ++DQ +Y L+ + K+TE L + ++ ES R L++
Sbjct: 331 EKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLK-KLTEDL-SCQRQNAESARCS-LEQ 387
Query: 476 ETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLD----IYE 531
+ + Q E + Q+ + L +E ++A + + + + ++ QA LD + +
Sbjct: 388 KIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQ 447
Query: 532 KLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQN 591
+LE L+E + E +A ++ + L R + +++K+N
Sbjct: 448 QLENNLEEFKQKLCRAEQAFQASQI-------------------KENELRRSMEEMKKEN 488
Query: 592 SLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLE 651
+L+ E + +V L EL LNQ+Q + +++ + L E I Q E
Sbjct: 489 NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQE 548
Query: 652 KDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTE- 710
++ L K K A+ + Q + LL RE ++Q+ K+ E+ LL+ E
Sbjct: 549 NSLT-LEKLKLAVADLEKQRDCS-QDLLKKREH--HIEQLNDKLSKTEKESKALLSALEL 604
Query: 711 -PKHVTENQKSKTL 723
K E ++ KTL
Sbjct: 605 KKKEYEELKEEKTL 618
Score = 84.0 bits (206), Expect = 5e-16
Identities = 139/672 (20%), Positives = 273/672 (40%), Gaps = 82/672 (12%)
Query: 137 QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYE---LVNP 193
QL+ N +LR K ++ L+ E +E ++ F E QL + E V E ++N
Sbjct: 282 QLKAQNQELRNKINELELRLQGHE--KEMKGQVNKFQELQLQL-EKAKVELIEKEKVLNK 338
Query: 194 LRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQL 253
R E+ + + + + + + +LK+LTE R+N + ++ E K+
Sbjct: 339 CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKE--KEKEF 396
Query: 254 IQQGDYRQENYDKVKSE----RDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTL 309
++ +Q ++ + E + L QE+ + + H +L+A T + +L +
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456
Query: 310 EQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHY 369
+Q L + ++ + Q E +R + EE + E + +KARE + + A +
Sbjct: 457 KQK--LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLE--AELKNI 512
Query: 370 KTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEK 429
K + N+ + E+++ K + LR+ ++ ++EN E AVA+ E+ +
Sbjct: 513 K-QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQ 571
Query: 430 DALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQ-------LLQEETARNLT 482
D L+K + +++ + TE + L +LK E E ++ + E + LT
Sbjct: 572 DLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLT 631
Query: 483 QCQLECEKYQKKLEVL-----TKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKEL 537
Q + E E Q K+ L T++ S + + R E+ +N + R +++ L+ +
Sbjct: 632 QMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIR-NLHNVLDSKS 690
Query: 538 DEIIMQ-TAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILK 596
E+ Q A +E + +AE + ++ K+ ++ + QL Q ++
Sbjct: 691 VEVETQKLAYMELQQKAE-------------FSDQKHQKEIENMCLKTSQLTGQ----VE 733
Query: 597 DLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIES-----VRQRDSKIDSLT------- 644
DLEH+ ++ + DR L+ + R L++S V D + L
Sbjct: 734 DLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM 793
Query: 645 -----------------ESIAQLEKDVSNLNKEKSALLQTK-NQMALDLEQLLNHREELA 686
S +LE D S N SA+LQ + + + LE +L
Sbjct: 794 HHSFANIIGEQGSMPSERSECRLEADQSPKN---SAILQNRVDSLEFSLESQKQMNSDLQ 850
Query: 687 AMKQILVKMHSKHSENSLLLTKTEPKHVTE-NQKSKTLNVPKEHEDNIFTPKPTLFTKKE 745
+ LV++ + EN + + V E +Q+ L N+ + KE
Sbjct: 851 KQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
Query: 746 APEWSKKQKMKT 757
K++T
Sbjct: 911 KELQLLNDKVET 922
Score = 84.0 bits (206), Expect = 5e-16
Identities = 145/676 (21%), Positives = 291/676 (43%), Gaps = 110/676 (16%)
Query: 43 KVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLL 102
K R+T++L + K + HN+ L+ EL + T + L+ +EE ++KL A Q
Sbjct: 418 KARLTQELQQAKNM-HNV--LQAELDKLTSVKQQLE----NNLEEFKQKLCRAEQAFQAS 470
Query: 103 TLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELT 162
++ +N+L ++ K L+K E QK E +L+ K ++++ L +
Sbjct: 471 QIK-ENELRRSMEEMKKENNLLKSHSE-----QKAREVCHLEAELK--NIKQCLNQSQNF 522
Query: 163 EEQYIKLKAFPEDQL-SIPEYVSVRFYEL-VNPLRKEICELQVKKNILAEELSTNKNQLK 220
E+ E L + E ++ + L + L+ + +L+ +++ + L ++ ++
Sbjct: 523 AEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIE 582
Query: 221 QLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDAL----EQ 276
QL D+ + +E + + ALEL K+ ++ + + KSE + L E
Sbjct: 583 QLN-----DKLSKTEKESKALLSALELK--KKEYEELKEEKTLFSCWKSENEKLLTQMES 635
Query: 277 EVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAH 336
E L+ K LE Q + E ++ V TLE ++R+N+ + +R H
Sbjct: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTLE------------MDRENLSVEIRNLH 683
Query: 337 EEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHD-ELEQIRLKTNQEIDQL 395
L+ ++E K A E+ +K E+ ++ H E+E + LKT+Q Q+
Sbjct: 684 NV--LDSKSVEVETQKLAYMELQQK---------AEFSDQKHQKEIENMCLKTSQLTGQV 732
Query: 396 RNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTE 455
+ ++ + N + +K+R +D +++ L D L+ S VT
Sbjct: 733 EDLEHKL---------QLLSNEIMDKDRCY---QDLHAEYESLRDL---LKSKDASLVTN 777
Query: 456 FLHQSKLKSFESERVQ------LLQEETAR--NLTQCQLECEKYQKKLEVLTKEFYSLQA 507
HQ L +F+ + ++ E+ + ++C+LE ++ K +L SL+
Sbjct: 778 EDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEF 837
Query: 508 SSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVP 567
S E + + NS+ Q + + +++ E++E +M+ ++ AE
Sbjct: 838 SLESQ----KQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAE----------TSQ 883
Query: 568 TTAKRRLKQSVH---LARRVLQLEKQNSLILKDLEHRKDQVTQLS---QELDRANSLLNQ 621
+K + S H +A + LE + K+L+ D+V QEL ++N LL
Sbjct: 884 RISKLQEDTSAHQNVVAETLSALENKE----KELQLLNDKVETEQAEIQELKKSNHLLED 939
Query: 622 TQQPYRYLIES-----------VRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQ 670
+ + + L E+ + +I+ LT+ L++ ++LN+EK L+Q
Sbjct: 940 SLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSES 999
Query: 671 MALDLEQLLNHREELA 686
A +++ EL+
Sbjct: 1000 FANYIDEREKSISELS 1015
Score = 76.6 bits (187), Expect = 8e-14
Identities = 148/721 (20%), Positives = 290/721 (40%), Gaps = 98/721 (13%)
Query: 35 SSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLND 94
+ + +E +R ++ I ++E ++ LK+ ++ D D L K E E+LND
Sbjct: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRD-CSQDLLKKREHHIEQLND 586
Query: 95 ALHQKQLLTLRLDNQLAFQQKDASKYQE------LMKQEMETILLRQKQLEETNLQLREK 148
L + + + L + L ++K+ + +E K E E LL Q + E+ NLQ K
Sbjct: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEK-LLTQMESEKENLQ--SK 643
Query: 149 AGDVRRNLRDFELTEEQYI-KLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNI 207
+ L+ ++ +Y +++ D+ E +SV L N L + E++ +K
Sbjct: 644 INHLETCLKTQQIKSHEYNERVRTLEMDR----ENLSVEIRNLHNVLDSKSVEVETQKLA 699
Query: 208 LAE-----ELSTNKNQ--LKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYR 260
E E S K+Q ++ + + +++ + Q L+ E+ D + Q
Sbjct: 700 YMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAE 759
Query: 261 QENYDKVKSERDAL---------------EQEVIELRRKHEILEASHMIQTKERSELS-- 303
E+ + +DA +Q + + I E M + L
Sbjct: 760 YESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEAD 819
Query: 304 ---KEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYE 360
K L+ V L+ E + N +L +C + L +++ ++EE+ E+M++
Sbjct: 820 QSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC----EELVQIKGEIEENLMKAEQMHQ 875
Query: 361 KYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAE 420
+VA ++ +KL ++ + + + L N +E+ + +
Sbjct: 876 SFVAET----SQRISKLQEDTSAHQNVVAETLSALENKEKEL-------------QLLND 918
Query: 421 KERAVMAEKDALEKHDQLL-DRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETAR 479
K AE L+K + LL D +ELQL +E T L + ++ S S + ++E T
Sbjct: 919 KVETEQAEIQELKKSNHLLEDSLKELQLLSE---TLSLEKKEMSSIISLNKREIEELTQE 975
Query: 480 NLTQCQLECEKYQKKLEVLTKE--FYSLQASSEKRITELQAQNSEHQARLDIYEKLEKEL 537
N T ++ Q+K+ ++ K F + EK I+EL Q + EKL
Sbjct: 976 NGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQ--------EKL---- 1023
Query: 538 DEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKD 597
I++Q E E + E + Y + + L + L ++N +
Sbjct: 1024 --ILLQRCE-ETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCEN-----RKN-----E 1070
Query: 598 LEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNL 657
LE K+ + QE + + Q +E+V+Q + +T++ + + L
Sbjct: 1071 LEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQ--ALRSEMTDNQNNSKSEAGGL 1128
Query: 658 NKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTEN 717
+E L + +N+M ++ LL E+L MK + K ++ E+ + + + N
Sbjct: 1129 KQEIMTLKEEQNKMQKEVNDLLQENEQL--MKVMKTKHECQNLESEPIRNSVKERESERN 1186
Query: 718 Q 718
Q
Sbjct: 1187 Q 1187
Score = 74.3 bits (181), Expect = 4e-13
Identities = 119/563 (21%), Positives = 227/563 (40%), Gaps = 84/563 (14%)
Query: 37 SEEREGKVRITRQLIERKELLHNIQLLKIEL-SQKTMMIDNLK-VDYLTKIE-ELEEKLN 93
SE E ++ + L + + L+ L SQK M D K + L +I+ E+EE L
Sbjct: 809 SERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLM 868
Query: 94 DALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVR 153
A Q +++ Q+D S +Q ++ + + + ++K+L+ N ++ + +++
Sbjct: 869 KAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQ 928
Query: 154 RNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELS 213
+ L E+ +L+ E LS+ +KE+ + EEL+
Sbjct: 929 ELKKSNHLLEDSLKELQLLSE-TLSLE--------------KKEMSSIISLNKREIEELT 973
Query: 214 TNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA 273
LK++ + +++ N + + + A + + ++ I E D+ K E+
Sbjct: 974 QENGTLKEINASLNQEKMNLIQ---KSESFANYIDEREKSI------SELSDQYKQEKLI 1024
Query: 274 LEQEVIELRRKHEILEASHMIQTKERSELS---KEVVTL-EQTVTLLQKDKEYLNRQNME 329
L Q E +E L + ++ S+L E +L E L++ KE +++ E
Sbjct: 1025 LLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQE 1084
Query: 330 LSVRCAHEEDRLERLQAQLEESKKA-REEMYEKYVASRDH---------YKTEYENKLHD 379
+ A E+R + L +LE ++A R EM + S+ E +NK+
Sbjct: 1085 FLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQK 1144
Query: 380 ELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLL 439
E+ + L+ N+++ ++ E E+ +R + +E+ + + LE + L
Sbjct: 1145 EVNDL-LQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL 1203
Query: 440 DRY-------------RELQLSTESKVTEFLH---QSKLKSFESERVQLLQEETARNLTQ 483
D Y +EL+L K E L Q+ E+ +Q +Q + L
Sbjct: 1204 DSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKD 1263
Query: 484 CQLEC-EKY------------------------QKKLEVLTKEFYSLQASSEKRITELQA 518
C+++ EKY KL L K LQA + +TEL
Sbjct: 1264 CEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELND 1323
Query: 519 QNSE-HQARLDIYEKLEKELDEI 540
SE A + E++ K L+E+
Sbjct: 1324 SRSECITATRKMAEEVGKLLNEV 1346
Score = 67.8 bits (164), Expect = 4e-11
Identities = 114/496 (22%), Positives = 218/496 (43%), Gaps = 100/496 (20%)
Query: 7 KESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKE--LLHNIQLLK 64
KE +KV + + L+T + ER + ++ + KE L ++ L+
Sbjct: 2425 KEQEKVQMKEKSSTAMEMLQT-----QLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479
Query: 65 IELSQKTMMIDNLKVDYL---TKIEELEEKLNDA---LHQKQLLTLRLDNQLAFQQKDAS 118
+E +Q +D K +Y+ + + L +++ D L +K RL NQ+ Q++ S
Sbjct: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539
Query: 119 KYQELMKQEMETILLRQKQLEETNL--QLREKAGDVRR---NLRD-FELTEEQYIKLKAF 172
K ++ E E L +++ LE NL +L +K ++ +L+D E+ + Y L
Sbjct: 2540 KLSQV---EGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL--- 2593
Query: 173 PEDQLSIPEYVSVRFYELVNPLRKEICELQVKKN-------------------------I 207
E++L + + + F E VN + + ELQ + + +
Sbjct: 2594 -ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQL 2652
Query: 208 LAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKV 267
L EE+ ++K+QLK+LT E +K +L+ Q+ ++G KV
Sbjct: 2653 LLEEIKSSKDQLKELTLENSELKK------------SLDCMHKDQVEKEG--------KV 2692
Query: 268 KSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQN 327
+ E + + E +KH+ L ++ T ++ E+ E+ T + +T +E L+ Q
Sbjct: 2693 REEIAEYQLRLHEAEKKHQAL----LLDTNKQYEV--EIQTYREKLT---SKEECLSSQK 2743
Query: 328 MELSVRCAHEEDRLERLQAQ---LEESKKAREEMYEKYV--ASRDHYKTEYENKL----H 378
+E+ + + +E+ L+A LEE KK + + KYV +++ + + + KL
Sbjct: 2744 LEIDLLKSSKEELNNSLKATTQILEELKKTKMDNL-KYVNQLKKENERAQGKMKLLIKSC 2802
Query: 379 DELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKH--- 435
+LE+ + +E+ QL+ A +E + D V E + K+ LE+
Sbjct: 2803 KQLEEEKEILQKELSQLQAA------QEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856
Query: 436 -DQLLDRYRELQLSTE 450
D+ LD+Y L +S E
Sbjct: 2857 ADEYLDKYCSLLISHE 2872
Score = 49.3 bits (116), Expect = 1e-05
Identities = 64/338 (18%), Positives = 153/338 (45%), Gaps = 39/338 (11%)
Query: 39 EREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEEL------EEKL 92
E E K+++ + + L +++L+ ++ K+D ++ +E++ E +L
Sbjct: 2564 ELEQKIQVLQS--KNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETEL 2621
Query: 93 NDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLR------ 146
+H+ T L +L+ ++ + +L+ +E+++ + K+L N +L+
Sbjct: 2622 QREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCM 2681
Query: 147 -----EKAGDVRRNLRDFEL---------------TEEQY-IKLKAFPEDQLSIPEYVSV 185
EK G VR + +++L T +QY ++++ + E S E +S
Sbjct: 2682 HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSS 2741
Query: 186 RFYE--LVNPLRKEICE-LQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQR 242
+ E L+ ++E+ L+ IL E T + LK + + +E+ + ++++ +
Sbjct: 2742 QKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKS 2801
Query: 243 LALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSEL 302
+L + K+++Q+ + + + + ++ +V EL + + L+ + +TKE E
Sbjct: 2802 CK-QLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEY 2860
Query: 303 SKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDR 340
+ +L + L+K KE L Q L + + ++ R
Sbjct: 2861 LDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSR 2898
Score = 47.0 bits (110), Expect = 7e-05
Identities = 101/468 (21%), Positives = 189/468 (40%), Gaps = 63/468 (13%)
Query: 100 QLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDF 159
QL + + +L Q+ + K E ++ E++TI + LE +NLQ + L+D
Sbjct: 1212 QLEAMLRNKELKLQESEKEK--ECLQHELQTI---RGDLETSNLQ--DMQSQEISGLKDC 1264
Query: 160 EL-TEEQYI----KLKAFPEDQLSIPEYVSVRFYELVNPLRKEICE-LQVKKNILAEELS 213
E+ EE+YI +L D + + +L N L K ICE LQ +K L EL+
Sbjct: 1265 EIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKL-NELEK-ICEILQAEKYELVTELN 1322
Query: 214 TNKNQLKQLTETY-EEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERD 272
++++ T EE K +EV+I L + + I G++ ++
Sbjct: 1323 DSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPN-------- 1374
Query: 273 ALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSV 332
EQ + L E H+ T E+ L++ LQ + + L+ Q+ ++S
Sbjct: 1375 --EQHPVSLAPLDESNSYEHL--TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSS 1430
Query: 333 RCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEI 392
+ + + ++ L+A E V S T N D +++++L + +
Sbjct: 1431 KMSELQTYVDSLKA-------------ENLVLS-----TNLRNFQGDLVKEMQLGLEEGL 1472
Query: 393 DQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESK 452
++S ++ +L D++ RA++ + + L Q S +
Sbjct: 1473 VPSLSSS---CVPDSSSLSSLGDSSFY---RALLEQTGDMSLLSNLEGAVSANQCSVDEV 1526
Query: 453 VTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKR 512
L + L E+ A+ + + + CE Y++ LE L ++ S K
Sbjct: 1527 FCSSLQEENLTRKETPSAP------AKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKE 1580
Query: 513 ITELQAQNSEHQARLDIYEKL-----EKELDEIIMQTAEIENEDEAER 555
I EL+ S + LD K E+ ++ T E+E++ AE+
Sbjct: 1581 IQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEK 1628
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 105 bits (261), Expect = 2e-22
Identities = 168/754 (22%), Positives = 306/754 (40%), Gaps = 117/754 (15%)
Query: 13 NISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLK--IELSQK 70
N+S L E LE T+ T E E +++I Q E + L + L+ ++S +
Sbjct: 526 NLSKDLMKEKAQLEKTIET----LRENSERQIKILEQ--ENEHLNQTVSSLRQRSQISAE 579
Query: 71 TMMIDNLKVDYLT--KIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEM 128
+ D K + + I+E KL+ +K+ + L++ ++ EL E
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Query: 129 ETILLRQK------------QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQ 176
E LL++K LE+ N +L + +++ L F+ Q L+ Q
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEK-ENSQ 698
Query: 177 LSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRK---NY 233
L R E + ++ +LQ++ L E K L+ L ++++ + +Y
Sbjct: 699 LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSY 758
Query: 234 SEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHM 293
+ I QRL L ++ + IQQ ++SE LE E L++ E L+
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQ----------LESELQDLEMENQTLQKNLEELK---- 804
Query: 294 IQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKK 353
I +K +L KE +LEQ + L+KDK+ L ++N L + ++ LE ++ +K
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
Query: 354 AREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYEREN---RNL 410
ENK + I ++ + +L ++E+ +R + L
Sbjct: 865 --------------------ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 411 REARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERV 470
R++ V+EK + D LEK L ++ L+ E LH + S + R
Sbjct: 905 VTLREDLVSEKLKTQQMNND-LEK---LTHELEKIGLNKE----RLLHDEQ--STDDSRY 954
Query: 471 QLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIY 530
+LL+ + L +K LE+ ++ +L+A E+ Q E + Y
Sbjct: 955 KLLESKLESTL----------KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1004
Query: 531 EKLEKELDE--IIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLE 588
E L++ DE ++ + I ED + T + LK + R++++E
Sbjct: 1005 EALKQRQDEERMVQSSPPISGEDNK--------WERESQETTRELLK----VKDRLIEVE 1052
Query: 589 KQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIA 648
+ N+ + + + K Q+ QL + N+L Q R + Q +L A
Sbjct: 1053 RNNATLQAEKQALKTQLKQLETQ---NNNLQAQILALQRQTVSLQEQN----TTLQTQNA 1105
Query: 649 QLEKDVSNLNKEKSALLQTKNQMAL-------DLEQLLNHREELAAMKQILVKMHSK--- 698
+L+ + S LN + ++L+ Q+ + + E ++ RE+L ++ L+K H K
Sbjct: 1106 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL 1165
Query: 699 -HSENSLLLTKTEPKHVTENQKSKTLNVPKEHED 731
H + KH T K L V EH D
Sbjct: 1166 LHERQASEYESLISKHGTLKSAHKNLEV--EHRD 1197
Score = 102 bits (254), Expect = 1e-21
Identities = 163/773 (21%), Positives = 329/773 (42%), Gaps = 62/773 (8%)
Query: 32 DDISSSEEREGKV-RITRQLIERKELLHNIQLLKI---ELSQKTMMIDNLKV---DYLTK 84
D++ + E+ +V ++ ++ KE LH+I+ K EL + ++ K D L
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 85 IEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQ 144
+KL++ + L +L + + D K +ELM++ M T+ + QKQ + +L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM-TLEMAQKQSMDESLH 428
Query: 145 LREKAGDVRRNLRDFELTEEQY-IKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQV 203
L + + R E ++ ++ +L E + + V LR + ++
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 204 KKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTK-QLIQQGDYRQE 262
+ + ++ +L + E E + + CQ L+ +L K QL + + +E
Sbjct: 489 NASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 263 NYDK----VKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQK 318
N ++ ++ E + L Q V LR++ +I + + ++ +++ E ++++T + L K
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE--SIKETSSKLSK 605
Query: 319 DKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASR-DHYKTEYENKL 377
E+ RQ + + +R E L+ +L +K E + +K + K E +
Sbjct: 606 -IEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 378 HDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQ 437
+ ELE+ K + +D +N + ++ E N + +N E R V + K A K Q
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN--LELRRNVESLKCASMKMAQ 722
Query: 438 LLDRYRELQLSTE--SKVTEFLHQSKLKS-----------FESERVQLLQEETARNLTQC 484
L +EL+ E K E L S K+ E++R+Q E + + + Q
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 485 QLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELD---EII 541
+ E + + + + L K L+ SS KR+ +L+ +N + EK +K+L+ + +
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISS-KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 542 MQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILK----- 596
Q AEI++ E + G T + + R+ +LEK+N ++K
Sbjct: 842 RQQAEIKDTTLEENNV-KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 597 ---------DLEHRKDQVTQLSQELDRANSLLNQT-QQPYRYLIESVRQRDSKIDSLTES 646
DL K + Q++ +L++ L + R L + DS+ L
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK 960
Query: 647 IAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLL- 705
+ K + +EK A L+ + + + + Q L R+EL +K+ + + E ++
Sbjct: 961 LESTLKKSLEIKEEKIAALEARLEESTNYNQQL--RQELKTVKKNYEALKQRQDEERMVQ 1018
Query: 706 ----LTKTEPKHVTENQK-SKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQ 753
++ + K E+Q+ ++ L K+ + TL +K+A + KQ
Sbjct: 1019 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1071
Score = 77.4 bits (189), Expect = 5e-14
Identities = 122/542 (22%), Positives = 245/542 (45%), Gaps = 65/542 (11%)
Query: 3 RKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQL 62
+++ KE+K++ +++ DI T+ D +S K++ + + ++L H ++
Sbjct: 884 KELEKENKELVKRATI---DIKTLVTLREDLVSE------KLKTQQMNNDLEKLTHELE- 933
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQK--DASKY 120
KI L+++ ++ D D ++ + LE KL L K+ L ++ + A + + +++ Y
Sbjct: 934 -KIGLNKERLLHDEQSTDD-SRYKLLESKLESTL--KKSLEIKEEKIAALEARLEESTNY 989
Query: 121 QELMKQEMETI-----LLRQKQLEETNLQLREK-AGDVRRNLRDFELTEEQYIKLKAFPE 174
+ ++QE++T+ L+Q+Q EE +Q +G+ + R+ + T + +K+K
Sbjct: 990 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK---- 1045
Query: 175 DQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYS 234
D+L E + L+ ++ +L+ + N L ++ + Q L E + +
Sbjct: 1046 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1105
Query: 235 EVQIR-----CQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILE 289
++Q+ Q +L + + LIQQ EN +K ER+ L+ L + HE LE
Sbjct: 1106 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK-EREDLKSLYDSLIKDHEKLE 1164
Query: 290 ASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEE-DRLERLQAQL 348
H Q E L + TL+ +N+E+ R + ++L + + QL
Sbjct: 1165 LLHERQASEYESLISKHGTLKSA------------HKNLEVEHRDLEDRYNQLLKQKGQL 1212
Query: 349 EESKKAREEMYEKYVASRDHYKT---EYENKLHDELEQIRLKTNQEIDQLRNASREMYER 405
E+ +K + EK + +++T EY+ KL E +++ N QL + E+ +
Sbjct: 1213 EDLEKMLKVEQEKMLLENKNHETVAAEYK-KLCGENDRL----NHTYSQLLKET-EVLQT 1266
Query: 406 ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSF 465
+++NL+ +N+ E+ R + AE L++ Q LD + + + E L Q K
Sbjct: 1267 DHKNLKSLLNNSKLEQTR-LEAEFSKLKEQYQQLD----ITSTKLNNQCELLSQLKGNLE 1321
Query: 466 ESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQA 525
E R L Q +T + LE K L F+ Q ++ EL+ Q + +
Sbjct: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKDL------FHVEQRQYIDKLNELRRQKEKLEE 1375
Query: 526 RL 527
++
Sbjct: 1376 KI 1377
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/280 (17%), Positives = 117/280 (41%), Gaps = 39/280 (13%)
Query: 481 LTQCQLECEKYQKKLEVLTKEFYSLQAS----------SEKRITELQAQNSEHQARLDI- 529
L C ++C+K ++ +E + + +A+ +++ + +LQ ++ DI
Sbjct: 128 LLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIE 187
Query: 530 ---------YEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVP--TTAKRRLKQSV 578
++L E DE E+ E + L A P + +R +
Sbjct: 188 PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ 247
Query: 579 HLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQP------------- 625
HL+ + + + + ++LE + +Q+ QEL++ L + QQ
Sbjct: 248 HLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARM 307
Query: 626 YRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSAL--LQTKNQMALDLEQLLNHRE 683
YR ++++R++ ++D L +++ ++ + ++ K+ + L+ NQ+ L+ + +L +
Sbjct: 308 YRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML--ED 365
Query: 684 ELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTL 723
+L + K+H EN L K + + K +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 105 bits (261), Expect = 2e-22
Identities = 167/780 (21%), Positives = 316/780 (40%), Gaps = 114/780 (14%)
Query: 18 LESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDN- 76
LE E+ SL TV + +I + E + L +++L+ E+ Q+ + N
Sbjct: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 77 --LKVDYLTKIEELEEKLNDALH--QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETIL 132
L D + + +LE+ + ++Q+ L +N+ Q + + + + E
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA---- 580
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIK-LKAFPEDQLSIPEYVSVRFYELV 191
R K +E+ N L E + L E + Q K L+ + E E
Sbjct: 581 -RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG------------ERA 627
Query: 192 NPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTK 251
L E+ L+ K+N L ++ TN LK E E + SE++ ++L L K
Sbjct: 628 EELENELHHLE-KENELLQKKITN---LKITCEKIEALEQENSELERENRKLKKTLDSFK 683
Query: 252 QLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTK---ERSELSKEVVT 308
L Q + ++ E L++E +ELRR E L+ + M + E EL E
Sbjct: 684 NLTFQ-------LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
Query: 309 LEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEM--------YE 360
L++ + LL+ + + +E+S + E+ +RLQ LE S K +++ E
Sbjct: 737 LKKGLELLKAS--FKKTERLEVSYQGLDIEN--QRLQKTLENSNKKIQQLESELQDLEME 792
Query: 361 KYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREA------- 413
++ + + +K ++LE+ QE QL +++ E+EN+ LR+
Sbjct: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQL-EKENKRLRQQAEIKDTT 851
Query: 414 ------------RDNAVAEKERAVMAEK----DALEKHDQLLDRYRELQLSTESKVTEFL 457
++N KE + E LEK ++ L + + + T + E L
Sbjct: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL 911
Query: 458 HQSKLKS-----------FESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQ 506
KLK+ E E++ L +E + + + KLE K+ ++
Sbjct: 912 VSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Query: 507 ASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSY----GY 562
E++I L+A+ E + ++L +EL + ++ + ER++ S G
Sbjct: 972 ---EEKIAALEARLEEST---NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
Query: 563 GANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQT 622
++ ++ + + R++++E+ N+ + + + K Q+ QL + N+L Q
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ---NNNLQAQI 1082
Query: 623 QQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMAL-------DL 675
R + Q +L A+L+ + S LN + ++L+ Q+ + +
Sbjct: 1083 LALQRQTVSLQEQN----TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1138
Query: 676 EQLLNHREELAAMKQILVKMHSK----HSENSLLLTKTEPKHVTENQKSKTLNVPKEHED 731
E ++ RE+L ++ L+K H K H + KH T K L V EH D
Sbjct: 1139 ESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV--EHRD 1196
Score = 104 bits (260), Expect = 3e-22
Identities = 161/772 (20%), Positives = 328/772 (42%), Gaps = 61/772 (7%)
Query: 32 DDISSSEEREGKV-RITRQLIERKELLHNIQLLKI---ELSQKTMMIDNLKV---DYLTK 84
D++ + E+ +V ++ ++ KE LH+I+ K EL + ++ K D L
Sbjct: 310 DELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEG 369
Query: 85 IEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQ 144
+KL++ + L +L + + D K +ELM++ M T+ + QKQ + +L
Sbjct: 370 TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENM-TLEMAQKQSMDESLH 428
Query: 145 LREKAGDVRRNLRDFELTEEQY-IKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQV 203
L + + R E ++ ++ +L E + + V LR + ++
Sbjct: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 204 KKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTK-QLIQQGDYRQE 262
+ + ++ +L + E E + + CQ L+ +L K QL + + +E
Sbjct: 489 NASKIL-KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 263 NYDK----VKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQK 318
N ++ ++ E + L Q V LR++ +I + + ++ +++ E ++++T + L K
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHE--SIKETSSKLSK 605
Query: 319 DKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASR-DHYKTEYENKL 377
E+ RQ + + +R E L+ +L +K E + +K + K E +
Sbjct: 606 -IEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
Query: 378 HDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQ 437
+ ELE+ K + +D +N + ++ E N + +N E R V + K A K Q
Sbjct: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN--LELRRNVESLKCASMKMAQ 722
Query: 438 LLDRYRELQLSTE--SKVTEFLHQSKLKS-----------FESERVQLLQEETARNLTQC 484
L +EL+ E K E L S K+ E++R+Q E + + + Q
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 485 QLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELD---EII 541
+ E + + + + L K L+ SS KR+ +L+ +N + EK +K+L+ + +
Sbjct: 783 ESELQDLEMENQTLQKNLEELKISS-KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
Query: 542 MQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILK----- 596
Q AEI++ E + G T + + R+ +LEK+N ++K
Sbjct: 842 RQQAEIKDTTLEENNV-KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 597 ---------DLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESI 647
DL K + Q++ +L++ L + L+ + D + L +
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL 960
Query: 648 AQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLL-- 705
K + +EK A L+ + + + + Q L R+EL +K+ + + E ++
Sbjct: 961 ESTLKKSLEIKEEKIAALEARLEESTNYNQQL--RQELKTVKKNYEALKQRQDEERMVQS 1018
Query: 706 ---LTKTEPKHVTENQK-SKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQ 753
++ + K E+Q+ ++ L K+ + TL +K+A + KQ
Sbjct: 1019 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1070
Score = 78.2 bits (191), Expect = 3e-14
Identities = 123/542 (22%), Positives = 243/542 (44%), Gaps = 66/542 (12%)
Query: 3 RKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQL 62
+++ KE+K++ +++ DI T+ D +S K++ + + ++L H ++
Sbjct: 884 KELEKENKELVKRATI---DIKTLVTLREDLVSE------KLKTQQMNNDLEKLTHELE- 933
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEE--LEEKLNDALHQKQLLTLRLDNQLAFQQKDASKY 120
KI L+++ ++ D D K+ E LE L +L K+ L+ +L ++++ Y
Sbjct: 934 -KIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL----EESTNY 988
Query: 121 QELMKQEMETI-----LLRQKQLEETNLQLREK-AGDVRRNLRDFELTEEQYIKLKAFPE 174
+ ++QE++T+ L+Q+Q EE +Q +G+ + R+ + T + +K+K
Sbjct: 989 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK---- 1044
Query: 175 DQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYS 234
D+L E + L+ ++ +L+ + N L ++ + Q L E + +
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104
Query: 235 EVQIR-----CQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILE 289
++Q+ Q +L + + LIQQ EN +K ER+ L+ L + HE LE
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK-EREDLKSLYDSLIKDHEKLE 1163
Query: 290 ASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEE-DRLERLQAQL 348
H Q E L + TL+ +N+E+ R + ++L + + QL
Sbjct: 1164 LLHERQASEYESLISKHGTLKSA------------HKNLEVEHRDLEDRYNQLLKQKGQL 1211
Query: 349 EESKKAREEMYEKYVASRDHYKT---EYENKLHDELEQIRLKTNQEIDQLRNASREMYER 405
E+ +K + EK + +++T EY+ KL E +++ N QL + E+ +
Sbjct: 1212 EDLEKMLKVEQEKMLLENKNHETVAAEYK-KLCGENDRL----NHTYSQLLKET-EVLQT 1265
Query: 406 ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSF 465
+++NL+ +N+ E+ R + AE L++ Q LD + + + E L Q K
Sbjct: 1266 DHKNLKSLLNNSKLEQTR-LEAEFSKLKEQYQQLD----ITSTKLNNQCELLSQLKGNLE 1320
Query: 466 ESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQA 525
E R L Q +T + LE K L F+ Q ++ EL+ Q + +
Sbjct: 1321 EENRHLLDQIQTLMLQNRTLLEQNMESKDL------FHVEQRQYIDKLNELRRQKEKLEE 1374
Query: 526 RL 527
++
Sbjct: 1375 KI 1376
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/280 (17%), Positives = 117/280 (41%), Gaps = 39/280 (13%)
Query: 481 LTQCQLECEKYQKKLEVLTKEFYSLQAS----------SEKRITELQAQNSEHQARLDI- 529
L C ++C+K ++ +E + + +A+ +++ + +LQ ++ DI
Sbjct: 128 LLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIE 187
Query: 530 ---------YEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVP--TTAKRRLKQSV 578
++L E DE E+ E + L A P + +R +
Sbjct: 188 PLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ 247
Query: 579 HLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQP------------- 625
HL+ + + + + ++LE + +Q+ QEL++ L + QQ
Sbjct: 248 HLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARM 307
Query: 626 YRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSAL--LQTKNQMALDLEQLLNHRE 683
YR ++++R++ ++D L +++ ++ + ++ K+ + L+ NQ+ L+ + +L +
Sbjct: 308 YRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML--ED 365
Query: 684 ELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTL 723
+L + K+H EN L K + + K +
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 105 bits (261), Expect = 2e-22
Identities = 143/704 (20%), Positives = 294/704 (41%), Gaps = 67/704 (9%)
Query: 53 RKELLHNIQLLKIELSQKTMMIDNLK---VDYLTKIEELEEKLNDA---LHQKQLLTLRL 106
R EL + L+ E+ T M++ + + + L +L D L ++ L +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 107 DNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQY 166
+L +++ + Q+ + +EME ++ + N+QL D ++ L+DF T E
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDFASTVEAL 1390
Query: 167 IKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELS---TNKNQLKQLT 223
+ K + ++ E ++ ++ E K L+ KN L +EL + + +QL
Sbjct: 1391 EEGKKRFQKEI---ENLTQQYEEKAAAYDK----LEKTKNRLQQELDDLVVDLDNQRQLV 1443
Query: 224 ETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVI---E 280
E+ ++ + ++ + ++ + AD + + +E K S ALE+ + E
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET--KALSLARALEEALEAKEE 1501
Query: 281 LRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED- 339
L R +++L+A + ++ K V LE++ L+ E + Q EL ED
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561
Query: 340 ------RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEID 393
++ L+ Q E +AR+E E+ EYE +L DE +Q L
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA----- 1616
Query: 394 QLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESK- 452
A+++ E + ++L D+A+ +E A+ K + Q+ D REL+ + S+
Sbjct: 1617 ----AAKKKLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASRD 1669
Query: 453 ---VTEFLHQSKLKSFESERVQLLQEETA--RNLTQCQLECEKYQKKLEVLTKEFYSLQA 507
T ++ K KS E++ +QL ++ A R Q LE E+ ++L +LQ
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729
Query: 508 SS---EKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGA 564
E RI +L+ + E Q + E + + + Q ++ NE ER A
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNM---EAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 565 NVPTTAK-RRLKQSVHLARRVLQLEKQNSLILKD--LEHRKDQVTQLSQELDRANSLLNQ 621
+ + L+ +H ++ + ++++ + + ++QV Q ++E A L Q
Sbjct: 1787 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846
Query: 622 TQQPYRYLIESVRQRDSKIDSLTES-------IAQLEKDVSNLNKEKSALLQTKNQMALD 674
+ + ++ V + E + QL++ + +E + + ++ +
Sbjct: 1847 KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1906
Query: 675 LEQLLNHREELAAMKQILVKMHSKHSENSLLLT-KTEPKHVTEN 717
L++ E + L + +E S + + ++ + V EN
Sbjct: 1907 LDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIEN 1950
Score = 94.0 bits (232), Expect = 5e-19
Identities = 140/667 (20%), Positives = 289/667 (43%), Gaps = 64/667 (9%)
Query: 95 ALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRR 154
A Q+QL +++ Q++ + Y +L + + + K L LQ+ + +++
Sbjct: 807 AKRQQQLTAMKVI------QRNCAAYLKLRNWQWWRLFTKVKPL----LQVTRQEEEMQA 856
Query: 155 NLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELST 214
+ + T+E+ K E++L E + E N L++++ + + + AEE+
Sbjct: 857 KEDELQKTKERQQKA----ENELKELEQKHSQLTEEKNLLQEQL-QAETELYAEAEEMRV 911
Query: 215 NKNQLKQ-LTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA 273
KQ L E E E + R Q+L A+ K++ QQ +E ++ ++ R
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQ---AERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 274 LEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQ-----TVTLLQKDKEYLNRQNM 328
L+ E + K + LE ++ + ++LSKE LE+ T L +++++ N +
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1028
Query: 329 ---------ELSVRCAHEE---DRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENK 376
EL VR EE LE+L+ +LE E A K + K
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1088
Query: 377 LHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHD 436
+EL+ + + EI Q NA +++ E E ++ + +++ +E+ AEK + +
Sbjct: 1089 -EEELQAALARLDDEIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAEKQKRDLGE 1146
Query: 437 QLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLE 496
+L EL+ + +S T+ ++K + + + L EET + Q Q +K+ + +E
Sbjct: 1147 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1206
Query: 497 VLT---KEFYSLQASSEKRITELQAQNSEHQARLDIY-----------EKLEKELDEIIM 542
LT ++F +A+ +K L+ +N++ L + +KLE ++ E+
Sbjct: 1207 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Query: 543 -----QTAEIENEDEAERVLFSYGYGANVPTTAK-RRLKQSVHLARRVLQLEKQNSLILK 596
+ A E D+ ++ + A+ + +K + +A QL+ L+ +
Sbjct: 1267 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1326
Query: 597 DLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSN 656
+ + + T+L Q + NSL +Q + +E+ + + I +L ++ +K + +
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEE----MEAKQNLERHISTLNIQLSDSKKKLQD 1382
Query: 657 LNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSE--NSLLLTKTEPKHV 714
AL + K + ++E L EE AA L K ++ + + L++ + +
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1442
Query: 715 TENQKSK 721
N + K
Sbjct: 1443 VSNLEKK 1449
Score = 92.8 bits (229), Expect = 1e-18
Identities = 164/765 (21%), Positives = 318/765 (41%), Gaps = 113/765 (14%)
Query: 16 SSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMID 75
S L E L+ + + +E E +VR+ + E +E+LH ++ E + +
Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942
Query: 76 NLKVDYLTKIEELEEKLNDALHQKQLLTL----------RLDNQLAF---QQKDASKYQE 122
+ ++ +LEE+L + +Q L L +L++++ Q SK ++
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 123 LMKQ---EMETILLRQKQLEETNLQLREK----AGDVRRNLRDFELTEEQYIKLKAFPE- 174
L+++ ++ T L +++ + +L+ K ++ L+ E + ++ KLK E
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 175 DQLSIPEYVS---VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTE------- 224
D E ++ + EL L K+ ELQ L +E++ N LK++ E
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 225 -----TYEEDRKNYSEVQIR-----CQRLALELADT-KQLIQQGDYRQENYDKVKSERDA 273
E +N +E Q R + L EL DT Q + R + +V + A
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 274 LEQE-------VIELRRKH--EILEASHMIQTKERSE--LSKEVVTLEQTVTLLQKDKEY 322
L++E V E+R+KH + E + ++ +R++ L K TLE+ L +
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 323 LNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKY------VASRDHYKTEYENK 376
L + E+ + E +++ LQ++ + ++AR E+ +K V S E E K
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 377 LHDELEQI-----RLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDA 431
+ + +L+ QE+ Q + + R L E R N++ ++ M K
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQN 1361
Query: 432 LEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKY 491
LE+H L+ +QLS K KL+ F S V+ L+E R +
Sbjct: 1362 LERHISTLN----IQLSDSKK--------KLQDFAS-TVEALEEGKKR-----------F 1397
Query: 492 QKKLEVLTKEFYSLQASSEK----------RITELQAQNSEHQARLDIYEKLEKELDEII 541
QK++E LT+++ A+ +K + +L + + EK +++ D+++
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 542 MQTAEIENE--DEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLE 599
+ I ++ DE +R + R L++++ + + K ++DL
Sbjct: 1458 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1517
Query: 600 HRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQ-----RDSKID---SLTESIAQLE 651
KD V + EL+++ L + + +E + D+K+ ++ Q E
Sbjct: 1518 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577
Query: 652 KDV---SNLNKEKSALLQTK-NQMALDLEQLLNHREELAAMKQIL 692
+D+ N+EK LQ + ++ +LE R AA K+ L
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1622
Score = 37.0 bits (84), Expect = 0.068
Identities = 53/283 (18%), Positives = 114/283 (40%), Gaps = 40/283 (14%)
Query: 6 SKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKI 65
+KE++K + SLE++ + L+ + + + + K + +L + +Q K
Sbjct: 1675 AKENEKK--AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1732
Query: 66 ELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMK 125
L + ++ + +E + +++ A Q + L+ L + + QK+ S Q+L +
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 126 QEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSV 185
Q E LR K L E G V+ + S +
Sbjct: 1793 QNKE---LRSK--------LHEMEGAVKSKFK--------------------STIAALEA 1821
Query: 186 RFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLAL 245
+ +L + +E E K + L +LK++ E++RK + + + ++
Sbjct: 1822 KIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--- 1874
Query: 246 ELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEIL 288
A KQL +Q + +E ++ + R L++E+ E +E +
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 105 bits (261), Expect = 2e-22
Identities = 143/704 (20%), Positives = 294/704 (41%), Gaps = 67/704 (9%)
Query: 53 RKELLHNIQLLKIELSQKTMMIDNLK---VDYLTKIEELEEKLNDA---LHQKQLLTLRL 106
R EL + L+ E+ T M++ + + + L +L D L ++ L +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 107 DNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQY 166
+L +++ + Q+ + +EME ++ + N+QL D ++ L+DF T E
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL----SDSKKKLQDFASTVEAL 1397
Query: 167 IKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELS---TNKNQLKQLT 223
+ K + ++ E ++ ++ E K L+ KN L +EL + + +QL
Sbjct: 1398 EEGKKRFQKEI---ENLTQQYEEKAAAYDK----LEKTKNRLQQELDDLVVDLDNQRQLV 1450
Query: 224 ETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVI---E 280
E+ ++ + ++ + ++ + AD + + +E K S ALE+ + E
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET--KALSLARALEEALEAKEE 1508
Query: 281 LRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEED- 339
L R +++L+A + ++ K V LE++ L+ E + Q EL ED
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568
Query: 340 ------RLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEID 393
++ L+ Q E +AR+E E+ EYE +L DE +Q L
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAA----- 1623
Query: 394 QLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESK- 452
A+++ E + ++L D+A+ +E A+ K + Q+ D REL+ + S+
Sbjct: 1624 ----AAKKKLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASRD 1676
Query: 453 ---VTEFLHQSKLKSFESERVQLLQEETA--RNLTQCQLECEKYQKKLEVLTKEFYSLQA 507
T ++ K KS E++ +QL ++ A R Q LE E+ ++L +LQ
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736
Query: 508 SS---EKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGA 564
E RI +L+ + E Q + E + + + Q ++ NE ER A
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNM---EAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793
Query: 565 NVPTTAK-RRLKQSVHLARRVLQLEKQNSLILKD--LEHRKDQVTQLSQELDRANSLLNQ 621
+ + L+ +H ++ + ++++ + + ++QV Q ++E A L Q
Sbjct: 1794 RQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853
Query: 622 TQQPYRYLIESVRQRDSKIDSLTES-------IAQLEKDVSNLNKEKSALLQTKNQMALD 674
+ + ++ V + E + QL++ + +E + + ++ +
Sbjct: 1854 KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRE 1913
Query: 675 LEQLLNHREELAAMKQILVKMHSKHSENSLLLT-KTEPKHVTEN 717
L++ E + L + +E S + + ++ + V EN
Sbjct: 1914 LDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIEN 1957
Score = 94.0 bits (232), Expect = 5e-19
Identities = 140/667 (20%), Positives = 289/667 (43%), Gaps = 64/667 (9%)
Query: 95 ALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRR 154
A Q+QL +++ Q++ + Y +L + + + K L LQ+ + +++
Sbjct: 814 AKRQQQLTAMKVI------QRNCAAYLKLRNWQWWRLFTKVKPL----LQVTRQEEEMQA 863
Query: 155 NLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELST 214
+ + T+E+ K E++L E + E N L++++ + + + AEE+
Sbjct: 864 KEDELQKTKERQQKA----ENELKELEQKHSQLTEEKNLLQEQL-QAETELYAEAEEMRV 918
Query: 215 NKNQLKQ-LTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDA 273
KQ L E E E + R Q+L A+ K++ QQ +E ++ ++ R
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQ---AERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 274 LEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQ-----TVTLLQKDKEYLNRQNM 328
L+ E + K + LE ++ + ++LSKE LE+ T L +++++ N +
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL 1035
Query: 329 ---------ELSVRCAHEE---DRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENK 376
EL VR EE LE+L+ +LE E A K + K
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK 1095
Query: 377 LHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHD 436
+EL+ + + EI Q NA +++ E E ++ + +++ +E+ AEK + +
Sbjct: 1096 -EEELQAALARLDDEIAQKNNALKKIRELEG-HISDLQEDLDSERAARNKAEKQKRDLGE 1153
Query: 437 QLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLE 496
+L EL+ + +S T+ ++K + + + L EET + Q Q +K+ + +E
Sbjct: 1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVE 1213
Query: 497 VLT---KEFYSLQASSEKRITELQAQNSEHQARLDIY-----------EKLEKELDEIIM 542
LT ++F +A+ +K L+ +N++ L + +KLE ++ E+
Sbjct: 1214 ELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Query: 543 -----QTAEIENEDEAERVLFSYGYGANVPTTAK-RRLKQSVHLARRVLQLEKQNSLILK 596
+ A E D+ ++ + A+ + +K + +A QL+ L+ +
Sbjct: 1274 KCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE 1333
Query: 597 DLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSN 656
+ + + T+L Q + NSL +Q + +E+ + + I +L ++ +K + +
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEE----MEAKQNLERHISTLNIQLSDSKKKLQD 1389
Query: 657 LNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSE--NSLLLTKTEPKHV 714
AL + K + ++E L EE AA L K ++ + + L++ + +
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449
Query: 715 TENQKSK 721
N + K
Sbjct: 1450 VSNLEKK 1456
Score = 92.8 bits (229), Expect = 1e-18
Identities = 164/765 (21%), Positives = 318/765 (41%), Gaps = 113/765 (14%)
Query: 16 SSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMID 75
S L E L+ + + +E E +VR+ + E +E+LH ++ E + +
Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949
Query: 76 NLKVDYLTKIEELEEKLNDALHQKQLLTL----------RLDNQLAF---QQKDASKYQE 122
+ ++ +LEE+L + +Q L L +L++++ Q SK ++
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 123 LMKQ---EMETILLRQKQLEETNLQLREK----AGDVRRNLRDFELTEEQYIKLKAFPE- 174
L+++ ++ T L +++ + +L+ K ++ L+ E + ++ KLK E
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 175 DQLSIPEYVS---VRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTE------- 224
D E ++ + EL L K+ ELQ L +E++ N LK++ E
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 225 -----TYEEDRKNYSEVQIR-----CQRLALELADT-KQLIQQGDYRQENYDKVKSERDA 273
E +N +E Q R + L EL DT Q + R + +V + A
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 274 LEQE-------VIELRRKH--EILEASHMIQTKERSE--LSKEVVTLEQTVTLLQKDKEY 322
L++E V E+R+KH + E + ++ +R++ L K TLE+ L +
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 323 LNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKY------VASRDHYKTEYENK 376
L + E+ + E +++ LQ++ + ++AR E+ +K V S E E K
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 377 LHDELEQI-----RLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDA 431
+ + +L+ QE+ Q + + R L E R N++ ++ M K
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEEMEAKQN 1368
Query: 432 LEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKY 491
LE+H L+ +QLS K KL+ F S V+ L+E R +
Sbjct: 1369 LERHISTLN----IQLSDSKK--------KLQDFAS-TVEALEEGKKR-----------F 1404
Query: 492 QKKLEVLTKEFYSLQASSEK----------RITELQAQNSEHQARLDIYEKLEKELDEII 541
QK++E LT+++ A+ +K + +L + + EK +++ D+++
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 542 MQTAEIENE--DEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLE 599
+ I ++ DE +R + R L++++ + + K ++DL
Sbjct: 1465 AEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLV 1524
Query: 600 HRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQ-----RDSKID---SLTESIAQLE 651
KD V + EL+++ L + + +E + D+K+ ++ Q E
Sbjct: 1525 SSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584
Query: 652 KDV---SNLNKEKSALLQTK-NQMALDLEQLLNHREELAAMKQIL 692
+D+ N+EK LQ + ++ +LE R AA K+ L
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKL 1629
Score = 37.0 bits (84), Expect = 0.068
Identities = 53/283 (18%), Positives = 114/283 (40%), Gaps = 40/283 (14%)
Query: 6 SKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKI 65
+KE++K + SLE++ + L+ + + + + K + +L + +Q K
Sbjct: 1682 AKENEKK--AKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR 1739
Query: 66 ELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMK 125
L + ++ + +E + +++ A Q + L+ L + + QK+ S Q+L +
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 126 QEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSV 185
Q E LR K L E G V+ + S +
Sbjct: 1800 QNKE---LRSK--------LHEMEGAVKSKFK--------------------STIAALEA 1828
Query: 186 RFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLAL 245
+ +L + +E E K + L +LK++ E++RK + + + ++
Sbjct: 1829 KIAQLEEQVEQEARE----KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK--- 1881
Query: 246 ELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEIL 288
A KQL +Q + +E ++ + R L++E+ E +E +
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 103 bits (257), Expect = 6e-22
Identities = 170/773 (21%), Positives = 319/773 (41%), Gaps = 126/773 (16%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+ S L +E + L+ + + +E E + R+T + E +E+ H+++ E ++
Sbjct: 874 LQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQH 933
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTL----------RLDNQ---LAFQQKDASKY 120
+ K I+ELEE+L + +Q L L +L+ + L Q +K
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Query: 121 QELMKQ---EMETILLRQKQLEETNLQLREK----AGDVRRNLRDFELTEEQYIKLKAFP 173
++L++ E T L +++ ++ +L+ K D+ LR E ++ K +
Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053
Query: 174 E-DQLSIPEYVS---VRFYELVNPLRKEICELQ----------VKKNILAEELSTNKNQL 219
E D + + ++ + EL L K+ ELQ +KN+ +++ ++Q+
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 220 KQLTETYEEDR--KNYSEVQIR-----CQRLALELADT-KQLIQQGDYRQENYDKVKSER 271
+L E E +R +N +E Q R + L EL DT Q + R + +V +
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Query: 272 DALEQE-------VIELRRKH-EILE--ASHMIQTKE-RSELSKEVVTLEQTVTLLQKDK 320
LE+E + E+R+KH + +E A + QTK ++ L K TLE L +
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233
Query: 321 EYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKY------------VASRDH 368
+ L + + + E +L+ LQ + E ++ R E+ +K + S+
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 369 YKTEYENKLHDELEQIRLKTNQEIDQLRNASR-------EMYERENRNLREARDNAVAEK 421
K+ K LE +L+ QE+ Q N + + E E + RE + E+
Sbjct: 1294 SKSSKLTKDFSALES-QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE---EE 1349
Query: 422 ERAVMAEKDALEKHDQLLDRYRELQ-----LSTESKVTEFL----------HQSKLKSF- 465
E EK H Q+ D ++++ L T +V L H+ K+ ++
Sbjct: 1350 EAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYD 1409
Query: 466 --ESERVQLLQE-----ETARNLTQCQLECEKYQKKLEVLTKEFYSLQA--SSEKRITEL 516
E + +L QE + Q EK QKK + L E ++ A + E+ E
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469
Query: 517 QAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQ 576
+A+ E +A L + L+E + Q AE+E ++ R T + +
Sbjct: 1470 EAREKETKAL-----SLARALEEAMEQKAELERLNKQFR------------TEMEDLMSS 1512
Query: 577 SVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRAN--------SLLNQTQQPYRY 628
+ + V +LEK + + +E K Q+ +L EL +L Q R
Sbjct: 1513 KDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERD 1572
Query: 629 LIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNH 681
L Q + K L + ++E ++ + K++S + + ++ +DL+ L H
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Score = 96.7 bits (239), Expect = 7e-20
Identities = 158/731 (21%), Positives = 304/731 (41%), Gaps = 90/731 (12%)
Query: 2 SRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIE--------- 52
++++ +K + E +++ E V SE + KV Q ++
Sbjct: 1208 TKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERV 1267
Query: 53 RKELLHNIQLLKIELSQKTMMID--NLKVDYLTK-IEELEEKLNDA---LHQKQLLTLRL 106
R EL + L++EL T ++ + K LTK LE +L D L ++ L L
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 107 DNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQY 166
+L + + + ++E +++E E +KQ+ + Q+ + + ++ E EE
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 167 IKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY 226
KL+ E LS V Y+ L K LQ + + L +L + L
Sbjct: 1388 RKLQKDLEG-LSQRHEEKVAAYD---KLEKTKTRLQQELDDLLVDLDHQRQSACNL---- 1439
Query: 227 EEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
E+ +K + ++ + ++ + A+ + + +E K S ALE+ + +K E
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET--KALSLARALEEA---MEQKAE 1494
Query: 287 ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRL---ER 343
+ + +T E +L + ++V L+K K L +Q E+ + ED L E
Sbjct: 1495 LERLNKQFRT-EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553
Query: 344 LQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQ--LRNASRE 401
+ +LE + +A + +E+ + RD E + +L ++ ++ + E Q + A+R+
Sbjct: 1554 AKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613
Query: 402 MYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSK 461
E + ++L D+A ++ A+ K + Q+ D REL T + E L Q+K
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAI---KQLRKLQAQMKDCMRELD-DTRASREEILAQAK 1669
Query: 462 -----LKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEK----- 511
LKS E+E +QL +E A + Q + E+ + E+ A EK
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729
Query: 512 RITELQAQNSEHQARLD-IYEKLEK---ELDEI----IMQTAEIENEDEAERVLFSYGYG 563
RI +L+ + E Q + I ++L+K ++D+I ++ + + + A + L
Sbjct: 1730 RIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE 1789
Query: 564 ANVPT-----TAKRRLKQSV-HLARRVLQLEKQ-----------------NSLILKDL-- 598
V T K + K S+ L ++ QLE+Q LKD+
Sbjct: 1790 LKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLL 1849
Query: 599 ---------EHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQ 649
E KDQ + S L + L + ++ + S R+ +++ TE+
Sbjct: 1850 QVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADA 1909
Query: 650 LEKDVSNLNKE 660
+ ++VS+L +
Sbjct: 1910 MNREVSSLKNK 1920
Score = 96.3 bits (238), Expect = 9e-20
Identities = 164/702 (23%), Positives = 278/702 (39%), Gaps = 120/702 (17%)
Query: 121 QELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIP 180
+E+M +E E + +R+KQL N L + E + Q + K ++QL
Sbjct: 845 EEMMAKEEELVKVREKQLAAEN------------RLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 181 EYVSVRFYELVNPLR------KEIC-ELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
+ EL L +EIC +L+ + E + + K++ + +E +
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 234 SEVQIRCQRLALELADT----KQLIQQGDYRQENYDKVKSERDALEQEVIE--------- 280
E + Q+L LE T K+L ++ ++ K+ E+ LE + E
Sbjct: 953 EEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEE 1012
Query: 281 --------LRRKHEI----LEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNM 328
L+ KHE LE + K+R EL K LE T L L Q
Sbjct: 1013 EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIA 1072
Query: 329 ELSVRCAHEEDRLERLQAQLEES--------KKARE---------EMYEKYVASR----- 366
EL ++ A +E+ L+ A++EE KK RE E E ASR
Sbjct: 1073 ELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK 1132
Query: 367 ---------DHYKTEYENKLHDEL--EQIRLKTNQEIDQLRNASRE---MYERENRNLRE 412
+ KTE E+ L +++R K QE++ L+ E +E + + +R+
Sbjct: 1133 QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQ 1192
Query: 413 ARDNAV---AEKERAVMAEKDALEKHDQLLDRYRELQLSTE---------------SKVT 454
AV AE+ K LEK Q L+ R +L+ E KV
Sbjct: 1193 KHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG-ELANEVKVLLQGKGDSEHKRKKVE 1251
Query: 455 EFLHQSKLKSFESERVQLLQEETARNLTQCQLECE-------KYQKKLEVLTKEFYSLQA 507
L + ++K E ERV + E A +T+ Q+E + + K LTK+F +L++
Sbjct: 1252 AQLQELQVKFNEGERV---RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALES 1308
Query: 508 SSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVP 567
+ LQ +N + +L + KL++ DE ++E E+EA+ L +
Sbjct: 1309 QLQDTQELLQEENRQ---KLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365
Query: 568 TT-AKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPY 626
K++++ SV +++++ L+ L R ++ +L++ + L Q
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL 1425
Query: 627 RYLIESVRQRDSKIDSLTESIAQL---EKDVSNLNKEK----SALLQTKNQMALDLEQLL 679
++ RQ ++ + QL EK +S E+ A + K AL L + L
Sbjct: 1426 LVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL 1485
Query: 680 NHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSK 721
E A + L K E+ + K V E +KSK
Sbjct: 1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527
Score = 95.5 bits (236), Expect = 2e-19
Identities = 151/776 (19%), Positives = 318/776 (40%), Gaps = 96/776 (12%)
Query: 5 ISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLK 64
++KE + V + + ++ E + + S+ K+++ QL EL + L+
Sbjct: 848 MAKEEELVKV----REKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELR 903
Query: 65 IELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLL---TLRLDNQLAFQQKDASKYQ 121
L+ K ++ + D ++EE EE+ +K+ + L+ QL ++ K Q
Sbjct: 904 ARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQ 963
Query: 122 --------ELMKQEMETILLRQK--QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKA 171
+L K E E I+L + +L + L ++ + NL + E + KLK
Sbjct: 964 LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKN 1023
Query: 172 FPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQL----KQLTETYE 227
E ++ E R + L K +L+ L+++++ + Q+ QL + E
Sbjct: 1024 KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 228 EDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEI 287
E + + V+ + + L ++L Q QE+ + ++ R+ E++ +L + E
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA 1143
Query: 288 LE-----------ASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAH 336
L+ A +++K E++ TLE+ + + + +++ + A
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE 1203
Query: 337 EEDRLERLQAQLEESKKAREE-----MYEKYVASRDHYKTEYE-NKLHDELEQIRLKTNQ 390
+ ++ +R++A LE++K+ E E V + +E++ K+ +L+++++K N
Sbjct: 1204 QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN- 1262
Query: 391 EIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTE 450
E +++R + + L ++ KD QL D LQ
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Query: 451 SKVTEFLHQSKLKSFESE----RVQLLQEETARNLTQCQL-----ECEKYQKKLEVLTKE 501
K++ +KLK E E R QL +EE A++ + Q+ + +KK+E
Sbjct: 1323 QKLS---LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379
Query: 502 FYSLQASSEKRITELQAQNSEHQARLDIYEKLEK-------ELDEIIM------------ 542
+ + K +L+ + H+ ++ Y+KLEK ELD++++
Sbjct: 1380 LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439
Query: 543 --------------QTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLE 588
+T + +E +R + R L++++ + +L
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499
Query: 589 KQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQ-----RDSKID-- 641
KQ ++DL KD V + EL+++ L Q + + +E + D+K+
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
Query: 642 -SLTESIAQLEKDVSNLNKE----KSALLQTKNQMALDLEQLLNHREELAAMKQIL 692
+L AQ E+D+ +++ K L++ +M +LE R A ++ L
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL 1615
Score = 94.4 bits (233), Expect = 4e-19
Identities = 163/746 (21%), Positives = 332/746 (44%), Gaps = 102/746 (13%)
Query: 8 ESKKVNISSSLESEDISLETTVPTDDISSSEE----REGKVRITRQLIERKELLHNIQLL 63
E +K ++ LE+ LE T+ D ++ +E RE +V I ++ +E + H Q+
Sbjct: 1131 EKQKRDLGEELEALKTELEDTL--DSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQ 1188
Query: 64 KI---------ELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQ 114
++ EL+++ +K + + LE + + ++ ++L + ++
Sbjct: 1189 EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 115 KDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPE 174
K ++ QEL + E +R +L + +L+ + +V L + + K + E
Sbjct: 1249 KVEAQLQELQVKFNEGERVRT-ELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 175 DQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYS 234
QL + EL+ ++ L K + +E ++ + QL++ EE+ K+
Sbjct: 1308 SQLQDTQ-------ELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE-----EEEAKHNL 1355
Query: 235 EVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMI 294
E QI L ++AD K+ ++ E ++VK + L++++ L ++HE A++
Sbjct: 1356 EKQIAT--LHAQVADMKKKMEDSVGCLETAEEVKRK---LQKDLEGLSQRHEEKVAAYDK 1410
Query: 295 QTKERSELSKEVVTL--------EQTVTLLQKDKEY--LNRQNMELSVRCAHEEDRLERL 344
K ++ L +E+ L + L +K K++ L + +S + A E DR E
Sbjct: 1411 LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA- 1469
Query: 345 QAQLEESK-----KAREEMYEKYVASR---DHYKTEYENKLHD---------ELEQIRLK 387
+A+ +E+K +A EE E+ ++TE E+ + ELE+ +
Sbjct: 1470 EAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA 1529
Query: 388 TNQEIDQLRNASREMYER----ENRNLR-EARDNAV-AEKERAVMA-EKDALEKHDQLLD 440
Q++++++ E+ + E+ LR E A+ A+ ER + ++ + EK QL+
Sbjct: 1530 LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVR 1589
Query: 441 RYRELQ--LSTESKVTEFLHQSKLK-SFESERVQLLQEETARNLTQCQLECEKYQKKLEV 497
+ RE++ L E K ++ K + + ++ + +N + + K Q +++
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKD 1649
Query: 498 LTKEFYSLQASSEKRITELQAQNSEHQARLDIYE----KLEKELD--EIIMQTAEIENED 551
+E +AS E E+ AQ E++ +L E +L++EL E + A+ E ++
Sbjct: 1650 CMRELDDTRASRE----EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 1705
Query: 552 EAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKD-LEHRKDQVTQLS- 609
A+ + S G GA + KRRL+ + L+ E+ N+ ++ D L+ Q+ Q++
Sbjct: 1706 LADEIANSSGKGA-LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINT 1764
Query: 610 ----------------QELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKD 653
Q+L+R N L Q ++S + + I +L IAQLE+
Sbjct: 1765 DLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS--KYKASITALEAKIAQLEEQ 1822
Query: 654 VSNLNKEKSALLQTKNQMALDLEQLL 679
+ N KE+ A + + L+ +L
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVL 1848
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 101 bits (252), Expect = 2e-21
Identities = 167/803 (20%), Positives = 340/803 (42%), Gaps = 127/803 (15%)
Query: 8 ESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVR-----ITRQLIERKELLHNI-- 60
E ++ + LE+++ SL ++ +D+ +EE+ ++ + R ++ + +H++
Sbjct: 481 ERAMTDLQNMLEAKNASLASS--NNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQ 538
Query: 61 -------QLLKIELSQKTMMIDNLKVDY--LTKIEELEEKLNDALHQKQLLTLRLDNQLA 111
QL +++L ++T + LK ++ ++ + + L Q +RL ++A
Sbjct: 539 QMTALQSQLQQVQL-ERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
Query: 112 FQQKDASKYQELMKQ-EMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTE-EQYIKL 169
Q L++ ++E + L Q+ E + ++EK G + L+ E +Q
Sbjct: 598 HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEK-GRIAAQLQGIEADMLDQEAAF 656
Query: 170 KAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
E + + E + R E + + +A+ ++ + QL+Q+ T +
Sbjct: 657 MQIQEAKTMVEEDLQRRLEEFEGE--------RERLQRMADSAASLEQQLEQVKLTLLQR 708
Query: 230 RKNYSEVQIRCQRLALELADTKQLIQQG----DYRQENYDKVKSERDALEQEVIE----- 280
+ +Q L +L T++ +Q D Q +YD++++ L+ E
Sbjct: 709 DQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTI 768
Query: 281 --LRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEE 338
L+ + ILEA+ + EL + LE+ + E L + S + H +
Sbjct: 769 CLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQ 828
Query: 339 DRLERLQAQLEESK------KAREEMYEKYVASRDHYKTEYE---NKLHDELEQIRLKTN 389
L+ Q+++ K K E Y + S+D +E + +L EL+++R +
Sbjct: 829 QETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELM 888
Query: 390 QEIDQLRNASREMYERENRNLREARDNAVAEKE---RAVMAEKDALEKHDQLLDRYRELQ 446
Q + R A E+ R +R + + R + +A+ E ++ E+D +E H Q L +E
Sbjct: 889 QVHGEKRTAEAEL-SRLHREVAQVRQH-MADLEGHLQSAQKERDEMETHLQSLQFDKEQM 946
Query: 447 LS-TES-----KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEK----YQKKLE 496
++ TE+ K E L Q K+ ++ ++ +LT Q E + Y+ +
Sbjct: 947 VAVTEANEALKKQIEELQQEARKAITEQKQKM--RRLGSDLTSAQKEMKTKHKAYENAVG 1004
Query: 497 VLTKEFYSLQASSEK---RITELQAQNSEHQARLDIYEK-----------------LEKE 536
+L++ A+ E + +L+AQ + L ++E+ LEKE
Sbjct: 1005 ILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKE 1064
Query: 537 LDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILK 596
L E+I T++ E E+ E+VL + L++S +++ +LE+ N +
Sbjct: 1065 LQEVIALTSQ-ELEESREKVL-----------ELEDELQESRGFRKKIKRLEESNKKLAL 1112
Query: 597 DLEHRKDQVTQLSQE---LDRANSLLN-----------QTQQPYRYLIESVRQRDSKIDS 642
+LEH K ++T L Q L NS+L Q + +++ + D ++
Sbjct: 1113 ELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKH 1172
Query: 643 LTESI-AQLEKDVSNLNKEKSALLQTKNQ--------MALDLEQLLNHREELAAMKQILV 693
L +++ A LEK+ +N K + K + A LE L ++EL A + ++
Sbjct: 1173 LVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLE-LSEVKKELQAKEHLVQ 1231
Query: 694 KMHSKHSENSLLLTKTEPKHVTE 716
K+ ++ + L E KH E
Sbjct: 1232 KLQAEADD----LQIREGKHSQE 1250
Score = 81.6 bits (200), Expect = 2e-15
Identities = 167/772 (21%), Positives = 308/772 (39%), Gaps = 120/772 (15%)
Query: 18 LESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNL 77
L+ E++SL + T+ S + +G++ Q IE L ++I+ KTM+ ++L
Sbjct: 613 LKLENVSLSQQL-TETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQ-EAKTMVEEDL 670
Query: 78 KV---------DYLTKIEELEEKLNDALHQKQLLTLRLDNQL-AFQQ------KDASKYQ 121
+ + L ++ + L L Q +L L+ D QL A QQ K + Q
Sbjct: 671 QRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQ 730
Query: 122 ELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPE 181
E ++ +++ Q +E +L E G+ L + + I L+A + S E
Sbjct: 731 EALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKE 790
Query: 182 YV----------SVRFYELVNPLRKEICELQVKKNILAEELSTNKNQL----------KQ 221
+ + E + LR+E+ + L +E + K Q+ K
Sbjct: 791 ELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKV 850
Query: 222 LTETYEEDRKN----YSEVQIRCQRLALELADTKQLIQQ--GDYRQENYDKVKSERDALE 275
+ E Y D + SE++ +RL EL + +Q + Q G+ R ++E L
Sbjct: 851 MVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRT-----AEAELSRLH 905
Query: 276 QEVIELRRKHEILEASHMIQTKERSELSKEVVTL----EQTVTLLQKD---KEYLNRQNM 328
+EV ++R+ LE KER E+ + +L EQ V + + + K+ +
Sbjct: 906 REVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQ 965
Query: 329 ELSVRCAHEEDRLERLQAQLEESKKAREEMYEKY-----VASRDHYKTEYENKLHD-ELE 382
E ++ ++ RL + L ++K + ++ Y + SR + + D EL
Sbjct: 966 EARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELG 1025
Query: 383 QIR---------LKTNQEIDQLR------NASREMYERENRNLREARDNAVAEKERAVMA 427
Q+R L ++ I L + S+ + E+E + + + E V+
Sbjct: 1026 QLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLE 1085
Query: 428 EKDALEKHDQLLDRYRELQLSTESKVTEFLHQS-KLKSFESERVQLLQEETARNLTQCQL 486
+D L++ + + L+ S + E H+ KL L + + +
Sbjct: 1086 LEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKR 1145
Query: 487 ECEKYQKKLEVLT----KE---------FYSLQASSEK---RITELQAQ----------N 520
E + Q L+V KE +LQAS EK ++ L+ Q N
Sbjct: 1146 EADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHN 1205
Query: 521 SEH--QARLDIYE-KLEKELDEIIMQTAEIENED-EAERVLFSYGYGANVPTTAKRRLKQ 576
H A L++ E K E + E ++Q + E +D + S A+ R +
Sbjct: 1206 RRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQL 1265
Query: 577 SVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQR 636
+ + QL KQ + +++E+ K +V Q +E+ L+ T+Q R +E ++Q
Sbjct: 1266 QLLQKQLDEQLSKQ-PVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQL 1324
Query: 637 ----DSKIDSLTESIAQLEKD-------VSNLNKEKSALLQTKNQMALDLEQ 677
S+++ E ++ +KD VS L LLQ Q+ LDL +
Sbjct: 1325 LQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRR 1376
Score = 32.0 bits (71), Expect = 2.2
Identities = 41/185 (22%), Positives = 77/185 (41%), Gaps = 24/185 (12%)
Query: 1 MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNI 60
+ + KE +KVN SL+ V + + R + +L E K+ L
Sbjct: 1177 LQASLEKEKEKVN----------SLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK 1226
Query: 61 QLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQ----QKD 116
+ L +L + + + + +I + + +L +A Q QLL +LD QL+ Q Q+
Sbjct: 1227 EHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEM 1286
Query: 117 ASKYQELMKQEMETILLRQ----------KQLEETNLQLREKAGDVRRNLRDFELTEEQY 166
+ E+ ++E E L+Q K+LE L+ ++ D +T++
Sbjct: 1287 ENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDK 1346
Query: 167 IKLKA 171
L+A
Sbjct: 1347 FMLQA 1351
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 101 bits (251), Expect = 3e-21
Identities = 173/757 (22%), Positives = 330/757 (43%), Gaps = 106/757 (14%)
Query: 8 ESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIEL 67
E KVN SL + LE V DD+ S E+E KVR+ + +RK L ++L
Sbjct: 1015 EEDKVN---SLSKSKVKLEQQV--DDLEGSLEQEKKVRMDLERAKRK--LEG----DLKL 1063
Query: 68 SQKTMM-IDNLKVDYLTKIEELE---EKLNDALHQKQLLTLRLDNQLAFQQKDASKYQEL 123
+Q+++M ++N K+ K+++ E + N + +Q+L L+L +L Q + +E
Sbjct: 1064 TQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEE 1123
Query: 124 MKQEMETILLRQK-------QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQ 176
++ E +K +LEE + +L E G + + E ++ K++ E+
Sbjct: 1124 LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA 1183
Query: 177 LSIPEYVSV----RFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKN 232
E + + + V L ++I LQ K L +E S K +L +T E+ K
Sbjct: 1184 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA 1243
Query: 233 YSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASH 292
+ ++ + L + + + +++ Q + + ++R L+ E EL R+ E EA
Sbjct: 1244 KANLEKVSRTLEDQANEYRVKLEEA---QRSLNDFTTQRAKLQTENGELARQLEEKEALI 1300
Query: 293 MIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCA-HEEDRLERLQAQLEES 351
T+ + ++++ L++ Q ++E + + +++ A H+ D L + E+
Sbjct: 1301 SQLTRGKLSYTQQMEDLKR-----QLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA 1355
Query: 352 KKAREEMYEKYVASRDHYKTEYENKLHDELEQI---------RLKTNQEIDQLRNASREM 402
K + + K + ++T+YE E++ RL+ +E + NA
Sbjct: 1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 403 YERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLD--------RYRELQLSTESKVT 454
E+ L+ ++ + + ER+ A AL+K + D +Y E Q ES
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERS-NAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1474
Query: 455 EFLHQS----KLKSFESERVQLLQ---------EETARNLTQCQL--------ECEKYQK 493
E S KLK+ E ++ L+ +E +LT+ QL E EK +K
Sbjct: 1475 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE-QLGEGGKNVHELEKVRK 1533
Query: 494 KLEVLTKEFYSLQASSEKRITE-----LQAQNSEHQARLDIYEKLEKELDEIIMQTAEIE 548
+LEV E S +E + L+AQ +Q + +I KL ++ +E M+ A+
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEE--MEQAKRN 1591
Query: 549 NE---DEAERVLFSYGYGANVPTTAKRRLK--------QSVHLARRVLQLEKQ-NSL--I 594
++ D + L + N K++++ Q H R + +KQ SL +
Sbjct: 1592 HQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSL 1651
Query: 595 LKDLEHRKDQVTQLSQEL-------DRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESI 647
LKD + + D + + +L +R N+LL + R ++E +R K+ + +
Sbjct: 1652 LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQT-ERSRKL--AEQEL 1708
Query: 648 AQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREE 684
+ + V L+ + ++L+ K +M DL QL + EE
Sbjct: 1709 IETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEE 1745
Score = 85.5 bits (210), Expect = 2e-16
Identities = 121/594 (20%), Positives = 252/594 (42%), Gaps = 61/594 (10%)
Query: 124 MKQEMETILLRQKQLEETNLQLREKAGDV-------RRNLRDFELTEEQYIKLKAFPEDQ 176
+K+ +E R+K+LEE + L ++ D+ + NL D E +Q IK K E +
Sbjct: 861 IKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAK 920
Query: 177 LSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEV 236
+ E + + EL KK L +E S K + L T + K
Sbjct: 921 VK-------EMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Query: 237 QIRCQRLALELADTKQLIQQ--------GDYRQENYDKVKSERD---ALEQEVIELRRKH 285
+ + + L E+A ++I + + Q+ D ++ E D +L + ++L ++
Sbjct: 974 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQV 1033
Query: 286 EILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQ 345
+ LE S + K R +L + LE + L Q+ L ++L + +E + +
Sbjct: 1034 DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQN 1093
Query: 346 AQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLR-NASREMYE 404
+++E+ + ++ +K ++ + +L +ELE R ++++LR + SRE+ E
Sbjct: 1094 SKIEDEQVLALQLQKKLKENQARIE-----ELEEELEAER-TARAKVEKLRSDLSRELEE 1147
Query: 405 RENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKS 464
R L EA + E E + + L + LQ + H +
Sbjct: 1148 ISER-LEEAGGATSVQIEMNKKREAEFQKMRRDLEE--ATLQHEATAAALRKKHADSVAE 1204
Query: 465 F--ESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSE 522
+ + +Q ++++ + ++ +LE + +E + K +A+ EK L+ Q +E
Sbjct: 1205 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK----AKANLEKVSRTLEDQANE 1260
Query: 523 HQARLDIYEKLEKELDEIIMQTAEIENE--------DEAERVLFSYGYGANVPTTAKRRL 574
++ +L E+ ++ L++ Q A+++ E +E E ++ G T L
Sbjct: 1261 YRVKL---EEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDL 1317
Query: 575 KQSVH--------LARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPY 626
K+ + LA + L+ + E + +L + L +ANS + Q + Y
Sbjct: 1318 KRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY 1377
Query: 627 RY-LIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLL 679
I+ + + L + + E+ V +N + S+L +TK+++ ++E L+
Sbjct: 1378 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM 1431
Score = 84.7 bits (208), Expect = 3e-16
Identities = 129/693 (18%), Positives = 285/693 (41%), Gaps = 51/693 (7%)
Query: 38 EEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDN----LKVDYLTKIEELEEKLN 93
EE G + ++ +++E Q ++ +L + T+ + L+ + + EL E+++
Sbjct: 1153 EEAGGATSVQIEMNKKREA--EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1210
Query: 94 DALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVR 153
+ KQ L + ++ + D + E + + + + LE+ + R K + +
Sbjct: 1211 NLQRVKQKLE-KEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQ 1269
Query: 154 RNLRDF-----ELTEEQYIKLKAFPEDQLSIPEYV--SVRFYELVNPLRKEICELQVKKN 206
R+L DF +L E + E + I + + + + + L++++ E KN
Sbjct: 1270 RSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKN 1329
Query: 207 ILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDK 266
LA L + ++ L E YEE+ + +E+Q + E+A + + ++ ++
Sbjct: 1330 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT--EE 1387
Query: 267 VKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQ 326
++ + L Q + + E + A K + L E+ L V L+++
Sbjct: 1388 LEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1447
Query: 327 NMELSVRCAHEEDRLERLQAQLEESKKAREEM----------YEKYVASRDHYKTEYEN- 375
A + + E Q++LE S+K + YE+ + + +K E +N
Sbjct: 1448 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL 1507
Query: 376 --KLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALE 433
++ D EQ+ + + + +L +++ E E L+ A + A A E A
Sbjct: 1508 QEEISDLTEQLG-EGGKNVHELEKVRKQL-EVEKLELQSALEEAEASLEHEEGKILRAQL 1565
Query: 434 KHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARN-LTQCQLECEKYQ 492
+ +Q+ E +L+ + + E ++ + +S + L E +RN + + + + E
Sbjct: 1566 EFNQIKAEI-ERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDL 1624
Query: 493 KKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDE 552
++E+ + A ++K++ LQ+ + Q +LD + +L E I A +E +
Sbjct: 1625 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI---AIVERRNN 1681
Query: 553 AERVLFSYGYGANVPTTAKRRLKQS--VHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQ 610
+ T R+L + + + RV L QN+ ++ + + +TQL
Sbjct: 1682 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQS 1741
Query: 611 ELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQ 670
E++ A ++ + I ++ ++ A LE+ N+ Q
Sbjct: 1742 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM-----------EQ 1790
Query: 671 MALDLEQLLNHREELAAM--KQILVKMHSKHSE 701
DL+ L+ E++A K+ L K+ ++ E
Sbjct: 1791 TIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1823
Score = 78.2 bits (191), Expect = 3e-14
Identities = 119/548 (21%), Positives = 230/548 (41%), Gaps = 65/548 (11%)
Query: 210 EELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKS 269
+E++T K + ++ ET E+ E++ + L E D + +Q Q+N + +
Sbjct: 849 KEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQA---EQDNLNDAEE 905
Query: 270 ERDALEQEVIELRRK----HEILEASHMIQTK----------ERSELSKEVVTLEQTVTL 315
D L + I+L K +E LE + + E SEL K++ LE T+
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965
Query: 316 LQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYEN 375
++K+K + L+ E L+ + A+L + KKA +E +++ + D + E E+
Sbjct: 966 VEKEKHATENKVKNLT----EEMAGLDEIIAKLTKEKKALQEAHQQ---ALDDLQVE-ED 1017
Query: 376 KLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKH 435
K+ + L + ++K Q++D L S E ++ +L A+ E D
Sbjct: 1018 KV-NSLSKSKVKLEQQVDDL-EGSLEQEKKVRMDLERAKRK----------LEGDLKLTQ 1065
Query: 436 DQLLDRYRE-LQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKK 494
+ ++D + LQL + K EF + E E+V LQ + + L + Q E+ +++
Sbjct: 1066 ESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQ--KKLKENQARIEELEEE 1123
Query: 495 LEV-------LTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEI 547
LE + K L E+ L+ ++++ +K E E ++ E
Sbjct: 1124 LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA 1183
Query: 548 ENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNS---LILKDLEHRKDQ 604
+ EA + +V +Q +L R +LEK+ S L L D+ +Q
Sbjct: 1184 TLQHEATAAALRKKHADSVAELG----EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQ 1239
Query: 605 VTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNK---EK 661
+ + L++ + L YR +E ++ ++ T A+L+ + L + EK
Sbjct: 1240 IIKAKANLEKVSRTLEDQANEYRVKLEEAQR---SLNDFTTQRAKLQTENGELARQLEEK 1296
Query: 662 SALLQ--TKNQMAL--DLEQLLNHREELAAMKQILV-KMHSKHSENSLLLTKTEPKHVTE 716
AL+ T+ +++ +E L EE K L + S + LL + E + +
Sbjct: 1297 EALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAK 1356
Query: 717 NQKSKTLN 724
+ + L+
Sbjct: 1357 AELQRVLS 1364
Score = 71.6 bits (174), Expect = 2e-12
Identities = 110/572 (19%), Positives = 242/572 (42%), Gaps = 71/572 (12%)
Query: 25 LETTVPTDDISSSEEREGKVR----------------ITRQLIERKELLHNIQ-LLKIEL 67
L T +D+ E EGK + + Q E E +Q +L
Sbjct: 1308 LSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN 1367
Query: 68 SQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDAS-----KYQE 122
S+ + D + + EELEE +K+L D + A + +A K +
Sbjct: 1368 SEVAQWRTKYETDAIQRTEELEEA------KKKLAQRLQDAEEAVEAVNAKCSSLEKTKH 1421
Query: 123 LMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELT-EEQYIKLKAFPEDQLSIPE 181
++ E+E +++ ++ L +K + + L +++ EE +L++ ++ S+
Sbjct: 1422 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL-- 1479
Query: 182 YVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQ 241
S ++L N + + L+ K E + ++ LTE E KN E++ +
Sbjct: 1480 --STELFKLKNAYEESLEHLETFKR----ENKNLQEEISDLTEQLGEGGKNVHELEKVRK 1533
Query: 242 RLALELADTKQLIQQGDYRQEN-----------YDKVKSERDAL----EQEVIELRRKHE 286
+L +E + + +++ + E+ ++++K+E + ++E+ + +R H+
Sbjct: 1534 QLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQ 1593
Query: 287 ----ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLE 342
L+ S +T+ R+E+ + +E + ++ + NR E + + L+
Sbjct: 1594 RVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1653
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREM 402
Q QL+++ +A +++ E N L ELE++R Q + A +E+
Sbjct: 1654 DTQIQLDDAVRANDDLKENIAIVE-----RRNNLLQAELEELRAVVEQTERSRKLAEQEL 1708
Query: 403 YERENR-NLREARDNAVAEKERAVMAEKDALEKH-DQLLDRYRELQLSTESKVT------ 454
E R L +++ ++ +++ + ++ L+ ++ + R + + +T
Sbjct: 1709 IETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMA 1768
Query: 455 EFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRIT 514
E L + + S ER++ E+T ++L Q +L+ E Q L+ K+ L+A +
Sbjct: 1769 EELKKEQDTSAHLERMKKNMEQTIKDL-QHRLD-EAEQIALKGGKKQLQKLEARVRELEG 1826
Query: 515 ELQAQNSEHQARLDIYEKLEKELDEIIMQTAE 546
EL+A+ + + K E+ + E+ QT E
Sbjct: 1827 ELEAEQKRNAESVKGMRKSERRIKELTYQTEE 1858
Score = 53.9 bits (128), Expect = 5e-07
Identities = 78/410 (19%), Positives = 183/410 (44%), Gaps = 34/410 (8%)
Query: 46 ITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLR 105
+T QL E + +H ++ ++ +L + + + + + +E E K+ A + +
Sbjct: 1514 LTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1573
Query: 106 LDNQLAFQQKD---ASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELT 162
++ +LA + ++ A + + + ++T L + + L++++K + +L + E+
Sbjct: 1574 IERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKK---MEGDLNEMEIQ 1630
Query: 163 EEQYIKLKAFPEDQL----SIPEYVSVRFYELV---NPLRKEICELQVKKNILAEELSTN 215
++ A + Q+ S+ + ++ + V + L++ I ++ + N+L EL
Sbjct: 1631 LSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE-- 1688
Query: 216 KNQLKQLTETYEEDRKNYSEVQIRC-QRLALELADTKQLIQQGDYRQENYDKVKSERDAL 274
+L+ + E E RK + I +R+ L + LI Q + + +++SE +
Sbjct: 1689 --ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEA 1746
Query: 275 EQEV--IELRRKHEILEASHMIQT-KERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELS 331
QE E + K I +A+ M + K+ + S + +++ + KD ++ + +++
Sbjct: 1747 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1806
Query: 332 VRCAHE-----EDRLERLQAQLEESKKAREEMYEKYVASRDH-----YKTEYENKLHDEL 381
++ + E R+ L+ +LE +K E + S Y+TE + K L
Sbjct: 1807 LKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRL 1866
Query: 382 EQIRLKTNQEIDQLRNASREMYERENRNL---REARDNAVAEKERAVMAE 428
+ + K ++ + + E E+ N NL R+ + +ERA +AE
Sbjct: 1867 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAE 1916
Score = 45.1 bits (105), Expect = 2e-04
Identities = 68/327 (20%), Positives = 140/327 (42%), Gaps = 52/327 (15%)
Query: 2 SRKISKESKKV-NISSSLESEDISLETTVPTDD-----ISSSEER----EGKVRITRQLI 51
+R ++ K+V ++ S L+ I L+ V +D I+ E R + ++ R ++
Sbjct: 1635 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVV 1694
Query: 52 ER---------KELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLL 102
E+ +EL+ + +++ SQ T +I N K + + +L+ ++ +A+ + +
Sbjct: 1695 EQTERSRKLAEQELIETSERVQLLHSQNTSLI-NQKKKMESDLTQLQSEVEEAVQECRNA 1753
Query: 103 TLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELT 162
+ + DA+ E +K+E +T LE + + D++ L
Sbjct: 1754 EEKAKKAIT----DAAMMAEELKKEQDT----SAHLERMKKNMEQTIKDLQHRL-----D 1800
Query: 163 EEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQL 222
E + I LK + QL + + R EL L E Q + + + ++ ++K+L
Sbjct: 1801 EAEQIALKG-GKKQL---QKLEARVRELEGELEAE----QKRNAESVKGMRKSERRIKEL 1852
Query: 223 TETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYR-----------QENYDKVKSER 271
T EED+KN +Q +L L++ K+ ++ + + Q D+ +
Sbjct: 1853 TYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1912
Query: 272 DALEQEVIELRRKHEILEASHMIQTKE 298
D E +V +LR K + A + +E
Sbjct: 1913 DIAESQVNKLRAKSRDIGAKQKMHDEE 1939
Score = 44.7 bits (104), Expect = 3e-04
Identities = 43/202 (21%), Positives = 93/202 (46%), Gaps = 10/202 (4%)
Query: 507 ASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANV 566
A +EK + ++ + + L+ E KEL+E ++ + +N+ + + V +
Sbjct: 845 AETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQ-VQAEQDNLNDA 903
Query: 567 PTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPY 626
+ +K + L +V ++ ++ L+D E ++T ++L+ S L +
Sbjct: 904 EERCDQLIKNKIQLEAKVKEMNER----LEDEEEMNAELTAKKRKLEDECSELKKDIDDL 959
Query: 627 RYLIESVRQR----DSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHR 682
+ V + ++K+ +LTE +A L++ ++ L KEK A LQ +Q ALD Q+ +
Sbjct: 960 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA-LQEAHQQALDDLQVEEDK 1018
Query: 683 EELAAMKQILVKMHSKHSENSL 704
+ ++ ++ E SL
Sbjct: 1019 VNSLSKSKVKLEQQVDDLEGSL 1040
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 100 bits (249), Expect = 5e-21
Identities = 161/707 (22%), Positives = 310/707 (43%), Gaps = 105/707 (14%)
Query: 21 EDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVD 80
EDISL+ + + + R I R+ + L ++ L IE K ++ ++
Sbjct: 1180 EDISLQKIRAESE--AKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237
Query: 81 YLTKIEE---LEEKLNDALHQKQLLTLRLDNQ----LAFQQKDASKYQELMK--QEMETI 131
+ ++EE L D L +K L L+ Q + ++ +EL+K ++ME
Sbjct: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKD 1297
Query: 132 LLRQKQLEETNLQLREKAG-DVRRNLRDFELTEEQYIKLKAFPEDQLSI----------- 179
L QKQ+ E L+ ++K + RR + + + T + L P Q +
Sbjct: 1298 LAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENA-LPVCPITQATSCRAVTGLQQEH 1356
Query: 180 ----PEYVSVRFYELVNPLRK---EICELQVKKNILAEELSTNKNQLKQLTETYEEDRKN 232
E + + EL RK ++ EL + N L E ++++ + + L + +E
Sbjct: 1357 DKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNT 1416
Query: 233 YSEVQIRCQRLALELAD------TKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
+RC +L LE D ++QL + G RQ N K+E E ++ +++
Sbjct: 1417 -----LRCLKLELERKDQAEKGYSQQLRELG--RQLNQTTGKAEEAMQEASDLKKIKRNY 1469
Query: 287 ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQA 346
LE + E+ +L +EV + + + +K+ ++LN Q + +E LERLQ
Sbjct: 1470 QLELESL--NHEKGKLQREVDRITRAHAVAEKNIQHLNSQ-----IHSFRDEKELERLQI 1522
Query: 347 QLEESKKAREEMYEKYVASRDHYKTEYEN-----KLHDELEQIRLKTNQEIDQLRNASRE 401
+S +E+ + + + K E EN +L++ELE K+N+ + L+ E
Sbjct: 1523 CQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELE----KSNECAEMLKQKVEE 1578
Query: 402 MYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLL----DRYRELQLSTESKVTEFL 457
+ R+N + AE E V+ EK +++ + L D +++ ST E L
Sbjct: 1579 L-TRQNNETKLMMQRIQAESENIVL-EKQTIQQRCEALKIQADGFKDQLRST----NEHL 1632
Query: 458 H-QSKLKSFESERVQLLQEETARN---LTQCQLECEKYQKKLEVLTKEFYSLQA-----S 508
H Q+K + +++ L+E+ A++ +++ + +C++ ++ KE +L A
Sbjct: 1633 HKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASK 1692
Query: 509 SEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPT 568
EKR E + Q + Q + ++ +L+K DE+ ++T E E + VLF G
Sbjct: 1693 EEKRRGEQKVQLQQAQVQ-ELNNRLKKVQDELHLKTIE-EQMTHRKMVLFQEESG----- 1745
Query: 569 TAKRRLKQSVHLARRVLQLEKQNSLILK-DLEHRKDQVTQLSQELDRA--NSLLNQTQ-- 623
+ KQS R+ ++ ++ +I + D+ + L QE RA N+ L +T
Sbjct: 1746 ----KFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIK 1801
Query: 624 ------QPYRYLIESVRQRDS----KIDSLTESIAQLEKDVSNLNKE 660
Q YR ++ + ++ K L + + +++V NL ++
Sbjct: 1802 ELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQK 1848
Score = 79.0 bits (193), Expect = 2e-14
Identities = 146/683 (21%), Positives = 291/683 (42%), Gaps = 123/683 (18%)
Query: 69 QKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRL-------DNQLAFQQKD----- 116
QK +++N K+ KI ELE + + QK + L +N+L QQ++
Sbjct: 1126 QKATVLENSKLT--GKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDIS 1183
Query: 117 -----ASKYQELMKQEMETILLRQKQLEETNLQ--------LREKAGDVRRNLRDFELTE 163
A + ++E+ETI+ R+K+ E L+ K V NL +F
Sbjct: 1184 LQKIRAESEAKQYRRELETIV-REKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQL 1242
Query: 164 EQYIKLKAFPEDQLSIPEY----VSVRFYELVNPLRK------EICEL--QVKKNILAEE 211
E+ + ED L + + + +L+ LR+ E+ +L Q++K+ LA +
Sbjct: 1243 EENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKD-LAFQ 1301
Query: 212 LSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYR--QENYDKVKS 269
+ QLK+ + E R+ +E+Q C+ AL + Q Q+ +DK K+
Sbjct: 1302 KQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKA 1361
Query: 270 ERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNME 329
E L+Q+V EL + E T E + L E + E+ LL K+ L+ N
Sbjct: 1362 EE--LKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLL---KDKLDETNNT 1416
Query: 330 LSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTN 389
L RC E LER ++++K + + + + E + + + ++K N
Sbjct: 1417 L--RCLKLE--LERK----DQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIKRN 1468
Query: 390 QEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLST 449
+++ L + + E + + R R +AVAEK + + + ++ L+R + Q +
Sbjct: 1469 YQLE-LESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKS 1527
Query: 450 ESKVTEF--LHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQA 507
+ +F H+ L++ ++E+ E + + E EK + E+L
Sbjct: 1528 DHLKEQFEKSHEQLLQNIKAEK------ENNDKIQRLNEELEKSNECAEML--------- 1572
Query: 508 SSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVP 567
++++ EL QN+E + + ++++ E + I+++ I+ EA ++ G+ +
Sbjct: 1573 --KQKVEELTRQNNETKLMM---QRIQAESENIVLEKQTIQQRCEALKIQAD-GFKDQLR 1626
Query: 568 TTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
+T + KQ+ + +++ + +DL ++ V++ Q+ D+ N ++ T+
Sbjct: 1627 STNEHLHKQT----KTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK---- 1678
Query: 628 YLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTK--NQMALDLEQL----LNH 681
K+V NLN E +A + K + + L+Q LN+
Sbjct: 1679 ------------------------KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714
Query: 682 REELAAMKQILVKMHSKHSENSL 704
R +K++ ++H K E +
Sbjct: 1715 R-----LKKVQDELHLKTIEEQM 1732
Score = 78.2 bits (191), Expect = 3e-14
Identities = 132/671 (19%), Positives = 280/671 (41%), Gaps = 119/671 (17%)
Query: 43 KVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLL 102
+V T++ I+ + N + L +L+Q+ M++ +++ +K++E ++ + +Q
Sbjct: 982 QVETTQRKIQENQP-ENSKTLATQLNQQKMLVSEIEMKQ-SKMDECQK------YAEQYS 1033
Query: 103 TLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELT 162
D +L Y+ ++ + ++ + R++ +L ++E D+R
Sbjct: 1034 ATVKDYEL-----QTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM-DLRTRYTALVTL 1087
Query: 163 EEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQL 222
QYIK F D L K + E ++K+ E + L++
Sbjct: 1088 MTQYIK---FAGDSL------------------KRLEEEEIKRCKETSEHGAYSDLLQRQ 1126
Query: 223 TETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELR 282
T E+ K ++ +R+ EL K +++ ++ R+A E E+ + +
Sbjct: 1127 KATVLENSKLTGKIS-ELERMVAELKKQKSRVEE---------ELPKVREAAENELRKQQ 1176
Query: 283 RKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLE 342
R E + + E + +E+ T+ + +++ E + + +E + A E+ L
Sbjct: 1177 RNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLL 1236
Query: 343 RLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREM 402
+ QLEE+ R + E ++ +D + E + + +E++R K + E ++L ++M
Sbjct: 1237 NFRNQLEENTFTRRTL-EDHLKRKDLSLNDLEQQKNKLMEELRRKRDNE-EELLKLIKQM 1294
Query: 403 YERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQL-------STESKVTE 455
E++ ++ + + EK++ E +A K ++ RE L +T +
Sbjct: 1295 -EKDLAFQKQVAEKQLKEKQKI---ELEARRKITEIQYTCRENALPVCPITQATSCRAVT 1350
Query: 456 FLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITE 515
L Q K E Q + E TA N K ++ + LT E +LQ
Sbjct: 1351 GLQQEHDKQKAEELKQQVDELTAAN--------RKAEQDMRELTYELNALQ--------- 1393
Query: 516 LQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLK 575
L+ +SE +ARL + +KL++ + + E+E +D+AE+ GY
Sbjct: 1394 LEKTSSEEKARL-LKDKLDETNNTLRCLKLELERKDQAEK-----GYSQQ---------- 1437
Query: 576 QSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQ 635
L++L + +Q T ++E + S L + ++ Y+ +ES+
Sbjct: 1438 -------------------LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH 1478
Query: 636 RDSK----IDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQI 691
K +D +T + A EK++ +LN + + K +LE+L + + +K+
Sbjct: 1479 EKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEK-----ELERLQICQRKSDHLKEQ 1533
Query: 692 LVKMHSKHSEN 702
K H + +N
Sbjct: 1534 FEKSHEQLLQN 1544
Score = 54.3 bits (129), Expect = 4e-07
Identities = 126/643 (19%), Positives = 254/643 (39%), Gaps = 97/643 (15%)
Query: 44 VRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLT 103
+R R +ER +L H E + ++ LK D T + EE + A + T
Sbjct: 761 IRQIRTPLERDDL-HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819
Query: 104 LRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLRE-KAGDVRRNLRDFELT 162
LR + + Q M Q +L+ NL L+ +A + L + +L
Sbjct: 820 LRSELNVVLQN---------MNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLC 870
Query: 163 EEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQL 222
EE+ A D+ +I +S + R E+ E + + L +EL K ++
Sbjct: 871 EEE-----AVIADKNNIENLIST-----LKQWRSEVDEKRQVFHALEDELQKAKAISDEM 920
Query: 223 TETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELR 282
+TY+E ++ + E AD QL+++ D + + + + + R
Sbjct: 921 FKTYKERDLDFDWHK--------EKAD--QLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 970
Query: 283 RKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLE 342
+ L+ IQ E ++ + E + TL + LN+Q M +S +E
Sbjct: 971 DTYHPLD--DWIQQVETTQRKIQENQPENSKTLATQ----LNQQKMLVS--------EIE 1016
Query: 343 RLQAQLEESKKAREEM---YEKYVASRDHYKTEYENKLHDELEQIRLKTN-----QEIDQ 394
Q++++E +K E+ + Y Y+ +++ +++ R++++ QE
Sbjct: 1017 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1076
Query: 395 LRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEK--HDQLLDRYRELQLSTESK 452
LR + + ++ A D+ +E + K+ E + LL R + L
Sbjct: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATVLENSKL 1136
Query: 453 VTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKR 512
+ ++ + ++ ++EE + + E K Q+ +E ++ + ++ +++
Sbjct: 1137 TGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQY 1196
Query: 513 ITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEA-ERVLFSYGYGANVPTTAK 571
EL+ E +A E+EL+ + T E E + A E L ++ T +
Sbjct: 1197 RRELETIVREKEAA-------ERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTR 1249
Query: 572 RRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIE 631
R L+ HL R+ L L DLE +K++ L+E
Sbjct: 1250 RTLED--HLKRK--------DLSLNDLEQQKNK------------------------LME 1275
Query: 632 SVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALD 674
+R++ + L + I Q+EKD++ + L+ K ++ L+
Sbjct: 1276 ELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELE 1318
Score = 33.1 bits (74), Expect = 0.98
Identities = 55/255 (21%), Positives = 101/255 (39%), Gaps = 41/255 (16%)
Query: 432 LEKHDQLLDRYRELQLST-ESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEK 490
LE H + E + S E+K++E + LK +E++ L+ + A+ L + +
Sbjct: 312 LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ--- 368
Query: 491 YQKKLEVL-------TKEFYSLQASSEKRIT-ELQAQNSEHQARLDIYEKLEKELDEIIM 542
++ L+ L T E L E+ + + +N+ + D + +L +ELD+
Sbjct: 369 -ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ--- 424
Query: 543 QTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQS-----VHLARRVLQLEKQNSLILKD 597
+ I++ E L + A + A R Q+ + L + V Q K+N+ +
Sbjct: 425 KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEF 484
Query: 598 LEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNL 657
K+ L ++ QR D + SI +LE V
Sbjct: 485 FNDAKEATDYLRN-------------------LKDAIQRKYSCDR-SSSIHKLEDLVQES 524
Query: 658 NKEKSALLQTKNQMA 672
+EK LLQ K+ +A
Sbjct: 525 MEEKEELLQYKSTIA 539
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 99.8 bits (247), Expect = 9e-21
Identities = 161/740 (21%), Positives = 315/740 (42%), Gaps = 108/740 (14%)
Query: 25 LETTVPTDD-ISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLT 83
L + P D+ SS+ ++ + + + + + +E LHN LK E+ QK N+K+D +
Sbjct: 406 LSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRT-SNIKLDKIM 464
Query: 84 KIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNL 143
K EL+E+ N + + ++ +++ + Q ++YQ +QE E +++ +E
Sbjct: 465 K--ELDEEGNQRRNLESTVS-QIEKEKMLLQHRINEYQRKAEQENE----KRRNVENEVS 517
Query: 144 QLREKAGDVRRNLRDFELTEEQYIKLKAFPE---DQLSIPEYVSVRFYELVNPLRKEIC- 199
L+++ D+++ ++ +L E+ +L+ E D L +VR + + K I
Sbjct: 518 TLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQ 577
Query: 200 ------ELQVKKNILAEELS-TNKN--QLKQLTETYEEDRKNYSEVQIRCQRLALELADT 250
ELQ + IL S T+K+ QL+ + E DR + SE+ Q A
Sbjct: 578 LESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQ------ARI 631
Query: 251 KQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLE 310
L ++ + + N +KV+ ER EA M+ E+ + + E+
Sbjct: 632 TSLQEEVKHLKHNLEKVEGERK----------------EAQDMLNHSEKEKNNLEIDLNY 675
Query: 311 QTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQ--AQLEESKKAREEMYEKYVASRDH 368
+ +L Q+ ++ +N + R + +E + A E KK +EE + A
Sbjct: 676 KLKSLQQRLEQEVNEHKVT-KARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRV 734
Query: 369 YKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAE 428
+ E + + D + LK +Q+ + ++E E E +NL + E + ++ +
Sbjct: 735 VQIEKQCSMLD----VDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQ---ESNKRLLLQ 787
Query: 429 KDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERV--QLLQEETARNLTQCQL 486
+ L+ D + L+ + ++ L +L FE ++ Q E Q QL
Sbjct: 788 NE-LKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQL 846
Query: 487 ECEKY-----QKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYE-KLEKE-LDE 539
E E+Y + +++ L +E + K+I ELQ + +LD+ E K E E L
Sbjct: 847 EAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLAR 906
Query: 540 IIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLE 599
+++ E E+++ A R ++ V +LE+ NS++ KD+E
Sbjct: 907 GLLEEQYFELTQESKKA-------------ASRNRQEITDKDHTVSRLEEANSMLTKDIE 953
Query: 600 HRKDQVTQLSQELDRA-----------------------NSLLNQTQQPYRYLIESVRQR 636
+ + +L++++ +A N+ Q L E + ++
Sbjct: 954 ILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRK 1013
Query: 637 DSKID---SLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHR-----EELAAM 688
D KID + T+ + + EK+ L E + + NQM + ++ LN EE A
Sbjct: 1014 DFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHR 1073
Query: 689 KQILVKMHSKHSENSLLLTK 708
++ +++ SK S+ L K
Sbjct: 1074 NELQMQLASKESDIEQLRAK 1093
Score = 79.7 bits (195), Expect = 9e-15
Identities = 107/466 (22%), Positives = 204/466 (43%), Gaps = 81/466 (17%)
Query: 38 EEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALH 97
EERE + + ++++ ++ +L ++L Q +++L + ++E+ + L L
Sbjct: 722 EEREAREKAENRVVQIEK---QCSMLDVDLKQSQQKLEHLTGNK-ERMEDEVKNLTLQLE 777
Query: 98 QKQLLTLRLDNQL---AFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRR 154
Q+ L L N+L AF+ + ++ MKQE+ T+L ++ LE QL ++
Sbjct: 778 QESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEG 837
Query: 155 NLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELST 214
+R+ + DQL +Y S + V L++EI E
Sbjct: 838 QMRELQ--------------DQLEAEQYFSTLYKTQVKELKEEIEE-------------K 870
Query: 215 NKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDAL 274
N+ LK++ E E ++ L+LA+TK +Q R L
Sbjct: 871 NRENLKKIQELQNEKETLATQ---------LDLAETKAESEQ------------LARGLL 909
Query: 275 EQEVIELRRKHEILEASHMIQTKERSELSKE---VVTLEQTVTLLQKDKEYLNRQNMELS 331
E++ EL ++ S ++ R E++ + V LE+ ++L KD E L R+N EL+
Sbjct: 910 EEQYFELTQE------SKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELT 963
Query: 332 --VRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTN 389
++ A EE +LE+ EE + +EK + + KT+ NKL + + + K +
Sbjct: 964 EKMKKAEEEYKLEK-----EEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKID 1018
Query: 390 QEIDQLRNASREMYERENRNLR-EARDNAVAEKERAVMAEKDALEKHDQLLDRYR----- 443
++ ++ ++ E+ENR L+ E + V +K+ + QL++
Sbjct: 1019 RKKANTQDLRKK--EKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNEL 1076
Query: 444 ELQLSTESKVTEFLHQSKLKSFESERVQLL--QEETARNLTQCQLE 487
++QL+++ E L L +S V +ET NL + ++E
Sbjct: 1077 QMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIE 1122
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 99.0 bits (245), Expect = 1e-20
Identities = 159/820 (19%), Positives = 344/820 (41%), Gaps = 106/820 (12%)
Query: 1 MSRKISKES-KKVNISSSLESEDISL----------ETTVPTDDISSSEEREGKVRITRQ 49
+ K ++ES K NI ++L +D+ ET++ + SE+ E ++ +
Sbjct: 321 LEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
Query: 50 LIE-------RKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDA----LHQ 98
L E K +Q + E Q + + + +K+ E E +L +A Q
Sbjct: 381 LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ 440
Query: 99 KQLLTLRL---DNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQ----------- 144
+QL + +L + Q+A Q S+ +E +K+++ Q QL++T Q
Sbjct: 441 RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 500
Query: 145 ---LREKAGDVRRNLRDFELTEEQYIKLKAF---PEDQLSIPEYVSVRFYELVNPLRKEI 198
LRE D+ + LR +++ L+A ++ +S+ E Y + E
Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560
Query: 199 C---ELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQ 255
+LQ K + L E+++ +LK +E++++ ++N + Q++ Q+ L A + L
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD-QVQEQKAHLRAAQDRVLSL 619
Query: 256 QGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTL 315
+ + N ++ ++ + Q I+++ K E+L ++ +T +R++L + T + +
Sbjct: 620 ETSVNELN-SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678
Query: 316 LQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAR----------EEMYEKYVAS 365
Q++ + Q +++ + +++ +L++ L+E K+ E +K A
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738
Query: 366 RDHYKTEYENKLHDELEQIRLKTNQEI------------DQLRNASREMYERENRNLREA 413
K E L D +Q +L T+ E+ ++ +++R ++++ L
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 414 RDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLL 473
+ ++E + ++D + ++ EL ++ VTE K + +
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858
Query: 474 QEETAR---NLTQCQLECEKYQKK-------LEVLTKEF-YSLQASSEKRITELQAQNSE 522
+++ ++ +L + E EK +K LE KE + LQ E + E +
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 523 HQARLDIYEKLEKELDEIIMQTAEIEN---EDEAERVLFSYGYGANVPTTAKRRLKQSVH 579
+ + +L+ EL+ + Q + +N ++E E N+ LKQS
Sbjct: 919 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ----GNI-----NELKQSSE 969
Query: 580 LARR---VLQLEKQNSLILK-DLEHR-KDQVTQLSQELDRANSLLNQTQQPYRYLIESVR 634
++ LQ E + +++ K +LE++ + Q+TQ +QEL ++ Q Y E+ +
Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029
Query: 635 QRDSKIDSLTESIAQLEKDVSNLNKEKSA----LLQTKNQMALDLEQLLNHREELAAMKQ 690
Q S + +D+ ++ ++ S L+ +NQ+ + + + A ++Q
Sbjct: 1030 QLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ 1089
Query: 691 ILVKMHSKHSENSLLL-----TKTEPKHVTENQKSKTLNV 725
K + E L K+ + N+KSK +
Sbjct: 1090 DSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI 1129
Score = 94.7 bits (234), Expect = 3e-19
Identities = 164/750 (21%), Positives = 322/750 (42%), Gaps = 89/750 (11%)
Query: 45 RITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELE------EKLNDALHQ 98
++ RQ+ ++ + + N++ L + + +++ + D KI+ E +L + H
Sbjct: 513 QVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHT 572
Query: 99 KQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRD 158
Q +L +L Q + + QE + +++ + ++ L L ++ L +
Sbjct: 573 LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNE 632
Query: 159 F-ELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKN 217
E + I++KA E LS + + +L N L LQ K+ +EL+
Sbjct: 633 SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ----QELNKITT 688
Query: 218 QLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQ--GDYRQENYD--KVKSERDA 273
QL Q+T ++ +++ S+++ + + +Q ++ G ++ D +VK+ ++
Sbjct: 689 QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 274 LEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVR 333
Q++ + R+ + LE + ++ E+ KE+V+ T LQK E L +L+ +
Sbjct: 749 ALQDLQQQRQLNTDLEL-RATELSKQLEMEKEIVS--STRLDLQKKSEALESIKQKLTKQ 805
Query: 334 CAHEEDRLERLQAQLEESKKAREEMYEKY---VASRDHYKTEYENKLHDELEQIRLKTNQ 390
++ + + +E+K EE+ + V K E E L EL ++ K ++
Sbjct: 806 EEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE-ALMTELSTVKDKLSK 864
Query: 391 EIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALE-KHDQLLDRYRELQLST 449
D L+N+ E +E+EN+ + A + + E+ K L+ + + L +EL+ S
Sbjct: 865 VSDSLKNSKSE-FEKENQKGKAA----ILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
Query: 450 ESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASS 509
E K E HQ KL+ + +QE+ L Q Q ++ +K+ + L L+ SS
Sbjct: 920 E-KEKEASHQLKLE------LNSMQEQ----LIQAQNTLKQNEKEEQQLQGNINELKQSS 968
Query: 510 EKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAE---------------IENEDEAE 554
E++ +++A E + + +LE +L + + Q A+ E E
Sbjct: 969 EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETF 1028
Query: 555 RVLFSYGYGANVPTTAKRR----LKQSVHLARRVL-----QLEKQNSLI---------LK 596
+ L S YG A R+ +++ + LA+ L Q+ QN LI L+
Sbjct: 1029 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088
Query: 597 DLEHRKDQVTQ----LSQELDRANSLLNQ---TQQPYRYLIESVRQRDSK-IDSLTESIA 648
+K+Q Q Q++ + SL + ++ IE ++ R K I L E +
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK 1148
Query: 649 --QLE--KDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSE--N 702
+LE K+++NL K L+Q K ++ + L E+ +QIL K E
Sbjct: 1149 SHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELK 1208
Query: 703 SLLLTKTEPKHVTENQKSKTLNVPKEHEDN 732
+ K H +K + K+HE+N
Sbjct: 1209 KEFIEKEAKLHSEIKEKEVGM---KKHEEN 1235
Score = 92.0 bits (227), Expect = 2e-18
Identities = 158/758 (20%), Positives = 317/758 (41%), Gaps = 131/758 (17%)
Query: 77 LKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMET---ILL 133
LK D +T + + + L +L +++ + L +K+ KYQ L +QE + +
Sbjct: 80 LKRDDVTLLRQEVQDLQASLKEEKWYSEEL-------KKELEKYQGLQQQEAKPDGLVTD 132
Query: 134 RQKQLEETNLQLREKAGDVRRNLRDF-ELTEEQYIKL-------KAFPEDQLSIPEYVSV 185
+L+ QL E+A N++ +L E++ +L K+ +++ S+ E
Sbjct: 133 SSAELQSLEQQL-EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQ 191
Query: 186 RFYELVNPLRKEICELQVKKNILA-----EELSTNKNQLKQLTE-----TYEEDRKNYSE 235
+ L L KE +Q K L E+++ K +L Q+ T E +R++ +
Sbjct: 192 KVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES-EK 250
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQ 295
++ C++L + A ++ I Q ++SE QEV ++ + L++S
Sbjct: 251 LKDECKKLQSQYASSEATISQ----------LRSELAKGPQEVAVYVQELQKLKSSVNEL 300
Query: 296 TKERSELSKEVVTLEQTVTLLQK--DKEYLNRQNME------------LSVRCAHEEDRL 341
T++ L++ ++ EQ T L++ ++E ++++N++ L R + E L
Sbjct: 301 TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL 360
Query: 342 ERLQAQLEESKKAREEMYEKYV---ASRDHYKTEYEN--KLHDELEQIRLKTNQEIDQLR 396
R+ +L E +A +++ E+ H K E++ + +E EQ L+ EI+QL
Sbjct: 361 HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 397 NASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLD---RYRELQLSTESKV 453
+ ++ E E R L EA KE+ ++ + ++K Q+ D + L+ + KV
Sbjct: 421 S---KLLETE-RQLGEAHGRL---KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473
Query: 454 T---EFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQA--- 507
T E HQ + + Q LQ+ T L + Q + E+ +++ ++ +L+A
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 508 SSEKRITELQAQNSEHQARLD-----------IYEKLEKELDEIIMQTAEIENEDEA--- 553
S++ I+ L+ + + A++ + EK +++ T +++N+ E+
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
Query: 554 --------------------ERVLFSYGYGAN-----------------VPTTAKRRLKQ 576
+RVL S N + AK L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVL-SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 652
Query: 577 SVHLARRVLQLEKQNSLILKD--LEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVR 634
S A+ + + QN L L+ ++ ++ +++ +LD+ + L Q+ L ++
Sbjct: 653 SAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 635 QRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQ--LLNHREELAAMKQIL 692
+ K SL + +LE + L + + +K Q DL+Q LN EL A +
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 772
Query: 693 VKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHE 730
K +S L + E+ K K +E +
Sbjct: 773 QLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQ 810
Score = 88.2 bits (217), Expect = 3e-17
Identities = 120/573 (20%), Positives = 263/573 (45%), Gaps = 74/573 (12%)
Query: 1 MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNI 60
+ +K++K+ ++ I + E +S ET + +++++ + + + +E++ L+ +
Sbjct: 798 IKQKLTKQEEEKQILKQ-DFETLSQETKIQHEELNNRIQTT-VTELQKVKMEKEALMTEL 855
Query: 61 QLLKIELSQKTMMIDNLKVDYLTK-------IEELEEKLNDALHQKQLLTLRLDNQLAFQ 113
+K +LS+ + + N K ++ + I +LE+ + HQ Q+ +++N L +
Sbjct: 856 STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV---QMENTLK-E 911
Query: 114 QKDASKYQELMKQEMETILLRQKQLEETNLQLR-------EKAGDVRRNLRDFELTEEQY 166
QK+ K E K+ + L ++E +Q + ++ ++ N+ + + + EQ
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQK 971
Query: 167 IKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETY 226
K + +L I ++ EL N L++++ + A+EL+ K ++ L Y
Sbjct: 972 KKQIEALQGELKI---AVLQKTELENKLQQQLTQA-------AQELAAEKEKISVLQNNY 1021
Query: 227 EEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE 286
E+ ++ + ++Q EL T+Q + K E+ +L QE + + +++
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDL-----------KSVEEKLSLAQEDL-ISNRNQ 1069
Query: 287 ILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQA 346
I + +IQ EL TLEQ ++ +L RC +D
Sbjct: 1070 IGNQNKLIQ-----ELKTAKATLEQDSA----------KKEQQLQERCKALQD------I 1108
Query: 347 QLEESKKAREEMYEK-YVASRDHYKTEYE---NKLHDELEQIRLKTNQEIDQLRNASREM 402
Q E+S K +E + EK +A + K E KL++EL+ +L++ +EI L++A + +
Sbjct: 1109 QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLL 1168
Query: 403 YER--ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDR-YRELQLSTESKVTEFLHQ 459
++ E + ++ AV +++R KD ++K ++ L + + E + S++ E +
Sbjct: 1169 IQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKE--KE 1226
Query: 460 SKLKSFESERVQLLQEETA--RNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQ 517
+K E +L + TA NL + E + Q+++ L K+ L+ +Q
Sbjct: 1227 VGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQ 1286
Query: 518 AQNSEHQARLDIYEKLEKELDEIIMQTAEIENE 550
E +A L+ K E E++++ + E++ +
Sbjct: 1287 NNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 98.2 bits (243), Expect = 2e-20
Identities = 157/799 (19%), Positives = 344/799 (43%), Gaps = 116/799 (14%)
Query: 2 SRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQ 61
S++I ++++ + + ++ + +++S EER ++ Q + +
Sbjct: 226 SQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQ--QGGSGVIETD 283
Query: 62 LLKIELSQKTMMIDNL-KVDYLTKIEELEEKLNDALHQKQLLTLRLDNQ-LAFQQKDASK 119
L KI QKT+ + + KV+ K+E+LE+K+ D K+L + D L +Q+ +
Sbjct: 284 LSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDI--NKKLSSAENDRDILRREQEQLNV 341
Query: 120 YQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSI 179
+ + +E E + L +L+ + ++ + + R L EE + +A + + I
Sbjct: 342 EKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEI 401
Query: 180 PEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIR 239
S+ N L ++ +L+++ +L +E S + ++L + + Y ++
Sbjct: 402 MRLSSL---NQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKST 458
Query: 240 CQR---LALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEAS-HMIQ 295
R L EL D + ++ +++ ++ SE++ L E+ EL R+++ EA+ HMI
Sbjct: 459 ATRDISLDSELHDLRLNLEA---KEQELNQSISEKETLIAEIEELDRQNQ--EATKHMIL 513
Query: 296 TKER------------SELSKEVVTLEQTVTLLQKDKEYLNRQ---------NMELSVRC 334
K++ S+L +++ ++ V L+ DK + ++ E+++
Sbjct: 514 IKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALND 573
Query: 335 AH-----EEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTN 389
H ED++E L QL +S+++ + ++ + ++H + E EL +IR +
Sbjct: 574 LHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEE-----ELSRIRNELM 628
Query: 390 QEIDQ-----------------LRNASREMYERE--NRNLREARDNAVAEKERAVMAEKD 430
Q ++Q +RN + + E E N NL++ + E E+ V+A +D
Sbjct: 629 QSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACED 688
Query: 431 ALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEK 490
+ ++ L +L L ++ + E L K + ++ E + E K
Sbjct: 689 VRHQLEECLAGNNQLSLE-KNTIVETLKMEKGE---------IEAELCWAKKRLLEEANK 738
Query: 491 YQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENE 550
Y+K +E L S R A EH+ + + +K + E+ E+ +++ +
Sbjct: 739 YEKTIEEL----------SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTD 788
Query: 551 DEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQ 610
+ K L S+ +++ QL + + ++ L K++ ++L +
Sbjct: 789 HK----------------ETKDVLSSSLEEQKQLTQLINKKEIFIEKL---KERSSKLQE 829
Query: 611 ELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQ 670
ELD+ + L + + L +++ ++D + S+ E L++++ L +E+S +
Sbjct: 830 ELDKYSQALRKNE----ILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADP 885
Query: 671 MALD-LEQLLNHREELAAMKQIL---VKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVP 726
LD + +L + +L +K+ L +K H K E+ +K + + QK +
Sbjct: 886 KTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQ-NQSKMQLLQSLQEQKKEMDEFR 944
Query: 727 KEHEDNIFTPKPTLFTKKE 745
+HE T K E
Sbjct: 945 YQHEQMNATHTQLFLEKDE 963
Score = 89.7 bits (221), Expect = 9e-18
Identities = 146/743 (19%), Positives = 304/743 (40%), Gaps = 107/743 (14%)
Query: 5 ISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQ----------LIERK 54
+ + +K + S++ E++ L+ + ++ S R ++ Q L ER+
Sbjct: 589 VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKERE 648
Query: 55 ELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQ 114
+ N++ EL Q + + D + E+L D HQ + L +NQL+ ++
Sbjct: 649 AEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEEC-LAGNNQLSLEK 707
Query: 115 KDASKYQELMKQEMETILL--RQKQLEETNLQLR--EKAGDVRR-NLRDFELTEEQYIKL 169
+ ++ K E+E L +++ LEE N + E+ + R N +L E IKL
Sbjct: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKL 767
Query: 170 KAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
+ +++ L+K I ++ + LS++ + KQLT+ +
Sbjct: 768 NQKKDMEIA--------------ELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKK 813
Query: 230 RKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDK-------VKSERDALEQEVIELR 282
+++ R +L EL Q +++ + ++ ++ +K E + L++E+ LR
Sbjct: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
Query: 283 RKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQ-NMELSVRCAHEEDRL 341
E S + L V L V+ L KE+L + + + ++
Sbjct: 874 E-----EQSRTAPVADPKTLD-SVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKM 927
Query: 342 ERLQAQLEESKKAREEMYEKYVASRDH-----YKTEYENKLHDELEQIRLKTNQEIDQLR 396
+ LQ+ E+ K+ E Y+ + H K E L +EQI+ + ++E ++
Sbjct: 928 QLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQ 987
Query: 397 NASREMYEREN------RNLREARDNAVAEKERAVMAEKD-------ALEKHDQLLDRYR 443
+ ++++ N E D + AE ER V K+ EK+ L +
Sbjct: 988 TDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQID 1047
Query: 444 ELQLSTESKVTEFLHQSKLK----------SFESERVQLLQEETARNLTQCQLECEKYQK 493
+L K+T+ + Q L+ + ++ V LQ++ L +E EK
Sbjct: 1048 QLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ----LQAYAMEREKVFA 1103
Query: 494 KLEVLTKE----------FYSLQASSEKRITELQAQNSEHQARL-----DIYEKLEKELD 538
L T+E + A+ E + +LQ +N + R D++ + + L
Sbjct: 1104 VLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLS 1163
Query: 539 EIIMQ-TAEIENEDEAERVLFSYGYGANVPTTA--------KRRLKQSVHLARRVLQLEK 589
II + EI+ + + L + ++ A + L++ L ++V ++E+
Sbjct: 1164 RIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEE 1223
Query: 590 QNSLILKDLEHRKDQVTQLSQELDRANSLL-------NQTQQPYRYLIESVRQRDSKIDS 642
++ +++ + + QL +EL + + + ++ Q Y LI+S Q ++K+ +
Sbjct: 1224 WKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKN 1283
Query: 643 LTESIAQLEKDVSNLNKEKSALL 665
+ +AQ++ + L K LL
Sbjct: 1284 FGQELAQVQHSIGQLCNTKDLLL 1306
Score = 72.4 bits (176), Expect = 1e-12
Identities = 144/712 (20%), Positives = 305/712 (42%), Gaps = 102/712 (14%)
Query: 67 LSQKTMMIDNLKVDYLTK-IEELEEKLND-------ALH------QKQLLTLRLD----- 107
L+ T I N D L + EE+E +L D A+H ++L L D
Sbjct: 23 LASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKH 82
Query: 108 --NQLAFQQKDASKYQELMKQEMETILLRQKQ--LEETNLQLREKAGDVRRNLRDFELTE 163
+++ +Q+ S +L ++E+E L+ +Q L++ L+L+ A V T
Sbjct: 83 EASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTA 142
Query: 164 EQYIKL------KAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKN 217
AF +D + + +S + + +N L E+ L+ + T+K
Sbjct: 143 SSSFAYGISHHPSAFHDDDMDFGDIISSQ--QEINRLSNEVSRLESEVGHWRHIAQTSKA 200
Query: 218 QLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQE 277
Q D + SE+ + Q + EL + Q+ D Q +++ A +Q+
Sbjct: 201 Q--------GTDNSDQSEI-CKLQNIIKELKQNRS--QEIDDHQHEMSVLQN---AHQQK 246
Query: 278 VIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHE 337
+ E+ R+H R ELS +E+ LLQ+ + ++ +
Sbjct: 247 LTEISRRH-------------REELSDYEERIEELENLLQQGGSGVIETDLS---KIYEM 290
Query: 338 EDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENK--LHDELEQIRLKTNQEIDQL 395
+ ++ LQ + ES K E++ +K + ++ L E EQ+ ++ Q +++
Sbjct: 291 QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEEC 350
Query: 396 RNASREMYERENRNLREARDNAVAEKERAVMAEKDALEK----HDQLLDRYRELQLSTES 451
N E + + ++++ + + EKER ++A+ ++E+ L D E+ +
Sbjct: 351 ENLKLECSKLQPSAVKQS--DTMTEKER-ILAQSASVEEVFRLQQALSDAENEIMRLSSL 407
Query: 452 KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEK 511
L + LK R+++L++E + L+Q E E+ Q L L E+ +++++ +
Sbjct: 408 NQDNSLAEDNLKL--KMRIEVLEKEKSL-LSQ---EKEELQMSLLKLNNEYEVIKSTATR 461
Query: 512 RITELQAQNSEHQARLDIYEKLEKELDEIIMQT----AEIE-----NEDEAERVLF---S 559
++ + H RL++ K E+EL++ I + AEIE N++ + ++
Sbjct: 462 ---DISLDSELHDLRLNLEAK-EQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQ 517
Query: 560 YGYGANVPTTAKRRLKQSVH-LARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSL 618
N + +LKQ ++ +RV QLE I K+L+ +K+++ Q L+ +
Sbjct: 518 LSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLT 577
Query: 619 LNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQL 678
+ + L++ + + S+ + +L++ + N+E+ + ++ + +L+ +
Sbjct: 578 KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQ-NEEELSRIRNELMQSLNQDSN 636
Query: 679 LNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHE 730
N ++ L ++ V+ +L +E + + EN K +V E+E
Sbjct: 637 SNFKDTLLKEREAEVR--------NLKQNLSELEQLNENLKKVAFDVKMENE 680
Score = 70.5 bits (171), Expect = 6e-12
Identities = 139/759 (18%), Positives = 302/759 (39%), Gaps = 118/759 (15%)
Query: 19 ESEDISLETTVPTDDISSSEERE--GKVRITRQLIERKELLHNIQLLKIELSQKTMMIDN 76
++ DI ET V + +I + E+ K R + KE I+LL + T ID
Sbjct: 989 DNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQ 1048
Query: 77 LKVDYLTKIEELEEKLN---DALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILL 133
L D + K+ ++ ++ + ALH + T + + QQ+ + M++E +L
Sbjct: 1049 LSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAY---AMEREKVFAVL 1105
Query: 134 RQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNP 193
+K E ++L+ +Y K+ + V+ + L+
Sbjct: 1106 NEKTRENSHLKT-------------------EYHKMM----------DIVAAKEAALIK- 1135
Query: 194 LRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQL 253
L+ E +L + +++ + ++ L+ E + +CQ L L +
Sbjct: 1136 LQDENKKLSTRFESSGQDMF--RETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTG 1193
Query: 254 IQQGDYRQENYDKVKSERDALEQEV---------------------IELRRKHEILEASH 292
+ G ++++ ERD L+Q+V +L+ + L+A
Sbjct: 1194 NEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQV 1253
Query: 293 MIQTKERSELSKE----VVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEE---DRLERLQ 345
++ + S+L + + + EQ T L+ + L + + C ++ +L+ +
Sbjct: 1254 LVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS 1313
Query: 346 AQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYER 405
QL + + E AS+ +E L ELE++R K+ QE D +E R
Sbjct: 1314 PQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELR-KSLQEKDATIRTLQENNHR 1372
Query: 406 ENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSF 465
+ ++ + E E+ K EK D L +E L ++K + L ++ +
Sbjct: 1373 LSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTN 1432
Query: 466 ESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQA 525
+ +LL++ ++++ +L + L+ +EK + + + +E+QA
Sbjct: 1433 KVNENELLRQAVT-----------NLKERILILEMDIGKLKGENEKIVETYRGKETEYQA 1481
Query: 526 RLDIYEKL-----EKELD-----EIIMQTAEIENEDEAERV-----LFSYGYGANVPTTA 570
+ K EKE + E + ++ E E + L + T
Sbjct: 1482 LQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVV 1541
Query: 571 KRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLI 630
++ + V LA + Q+E N+ + +++ +D+ + +QEL+R + L +++ Y
Sbjct: 1542 FQQERDQVMLALKQKQME--NTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREA 1599
Query: 631 ESVRQRDSKI---------------DSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDL 675
+ R++K+ +++ + Q V +L ++ + + + +++ AL L
Sbjct: 1600 LAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQL 1659
Query: 676 ----EQLLNHREELAAMKQILVKMHSKHSENSLLLTKTE 710
EQ+ + LA ++ +L H + E ++ + E
Sbjct: 1660 SVSQEQVKQYALSLANLQMVL--EHFQQEEKAMYSAELE 1696
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 97.8 bits (242), Expect = 3e-20
Identities = 166/735 (22%), Positives = 308/735 (41%), Gaps = 93/735 (12%)
Query: 18 LESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNL 77
LESE + ++ V S ++EG+ R Q +R+ +Q + E + + +
Sbjct: 708 LESEADARQSKV----YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 78 KVDYLTK--IEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQ 135
+ D+ + EE E+ L + L + + QL +++ + + L ++E + RQ
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823
Query: 136 KQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLR 195
++ E LQ E+ ++R R +L EE+ L+ E + S + ++ + R
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEED-GLQEDQERRRSQEQRRDQKWRWQLEEER 882
Query: 196 KEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQ 255
K K L E+L + QL + EE+ + + R Q Q
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQ----QLLQEEEEELQREEREKRRRQE------------Q 926
Query: 256 QGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTL 315
+ YR+E ++++ E + L +E E RR+ E +ER + K+ ++ L
Sbjct: 927 ERQYREE--EQLQQEEEQLLREEREKRRRQE----------RER-QYRKDKKLQQKEEQL 973
Query: 316 LQKDKEYLNRQNMELSVRCAHEEDRLERLQAQL--EESKKAREEMYEKYVASRDHYKTEY 373
L ++ E RQ E R EE+ L++ + QL EE +K R + +E+ +D + E
Sbjct: 974 LGEEPEKRRRQEREKKYR---EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 374 ENKLHDELEQIRL---------------------------KTNQEIDQLRNASREMYERE 406
E L +E E+ RL + QE+++ E+ + E
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Query: 407 NRNLREARD-NAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSF 465
+ LRE + E+ER E++ ++ +QLL RE + E + ++ + ++
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELE-RQYREEEEV--- 1146
Query: 466 ESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQA 525
+ E QLL+EE + Q +LE +Y+++ E+ +E L+ EKR E + Q E +
Sbjct: 1147 QQEEEQLLREEPEKRRRQ-ELE-RQYREEEELQQEEEQLLREEQEKRRQERERQYREEE- 1203
Query: 526 RLDIYEKLEKELDEIIMQTAEIENEDEAER-VLFSYGYGANVPTTAKRRLKQSVHLARRV 584
L ++ ++ DE + + E E E V + Y R+L+ S
Sbjct: 1204 ELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS------- 1256
Query: 585 LQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLT 644
QL + S +DL+H + + +E +R P +E Q+++K
Sbjct: 1257 -QLRDRQS--QQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAK---RR 1310
Query: 645 ESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSL 704
+ +Q EK + +E+ Q ++ + EQLL REE +Q + K E L
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ---ERDRKFREEEL 1367
Query: 705 LLTKTEPKHVTENQK 719
+ K + E Q+
Sbjct: 1368 RHQEQGRKFLEEEQR 1382
Score = 97.4 bits (241), Expect = 4e-20
Identities = 157/785 (20%), Positives = 325/785 (41%), Gaps = 110/785 (14%)
Query: 3 RKISKESKKVNISSSLESE-------DISLETTVPTDDISSSEEREGKVRITRQLIERKE 55
+++ ++ ++ + L SE + E + ++ E+ + R+ R+ ER++
Sbjct: 517 QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576
Query: 56 LLHNIQLLKIE---------LSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRL 106
QLLK E Q+ + LK + + ++E+ EE+ L +++ R
Sbjct: 577 -----QLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ-EERREQRLKREEPEEERR 630
Query: 107 DNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQY 166
L ++++ + Q+L +++ E R K+ EE + + R+ EL EE+
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 167 IKLK-----AFPEDQLSIPEYVSVRFYELVNPLRKE----------------ICELQVKK 205
+ + P+ Q + R ++ + RK+ ELQ ++
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Query: 206 NILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQL-IQQGDYRQENY 264
A + Q + T ++ + K+ Q R L +QL ++ R++ +
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810
Query: 265 DKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKE--Y 322
+ E++ ++ E ++ + LE +Q +ER++ L++ LQ+D+E
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ------QLQEEEDGLQEDQERRR 864
Query: 323 LNRQNMELSVRCAHEEDRLER---------LQAQL-EESKKAREEMYEKYVASRDHYKTE 372
Q + R EE+R R LQ QL +E + +EE E R+ + +
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 373 YENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDAL 432
+ + + E EQ++ QE +QL RE R+ R + +D + +KE ++ E+
Sbjct: 925 EQERQYREEEQLQ----QEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 433 EKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEK-Y 491
+ + +YRE + + E QLL+EE + Q E E+ Y
Sbjct: 981 RRRQEREKKYREEE-----------------ELQQEEEQLLREEREKRRRQ---EWERQY 1020
Query: 492 QKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENED 551
+KK E+ +E L+ EKR + Q E Q R + E+L++E ++++ + E
Sbjct: 1021 RKKDELQQEEEQLLREEREKR----RLQERERQYREE--EELQQEEEQLLGEERETRRRQ 1074
Query: 552 EAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQE 611
E ER Y + ++ L++ RR Q ++ ++L+ ++Q+ + +E
Sbjct: 1075 ELER---QYRKEEELQQEEEQLLREEPEKRRR--QERERQCREEEELQQEEEQLLREERE 1129
Query: 612 LDRANSLLNQTQQPYRYLIESVRQRDSKI------DSLTESIAQLEKDVSNLNKEKSALL 665
R L Q ++ E V+Q + ++ + + + ++ L +E+ LL
Sbjct: 1130 KRRRQELERQYREE-----EEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 666 QTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNV 725
+ + + E+ +REE +Q + + + S L + EP+ + +K
Sbjct: 1185 REEQEKRRQ-ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243
Query: 726 PKEHE 730
+E+E
Sbjct: 1244 GRENE 1248
Score = 94.4 bits (233), Expect = 4e-19
Identities = 118/527 (22%), Positives = 228/527 (43%), Gaps = 73/527 (13%)
Query: 36 SSEEREGKVRITRQLIERKE----LLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEK 91
S +ER+ K R Q + R+E L Q L+ E +K + L L+E+
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL----------LQER 1473
Query: 92 LNDALHQKQL--LTLRLDNQLAFQQKDAS-KYQELMKQEMETILLRQKQ----------- 137
LH+++ L + QL Q++D + QEL QE E L ++Q
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF 1533
Query: 138 LEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKE 197
L+E R++ G RR RD + EE+ ++ + E QLS E
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER-EEQQLSRQE---------------- 1576
Query: 198 ICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQG 257
+ +K L E+ + Q ++ E ++ R+ + Q+R +R + + +QL+Q+
Sbjct: 1577 ----RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER-DRKFREDEQLLQER 1631
Query: 258 D----YRQENYDKVKSERDALEQEVIELRRKHE----ILEASHMIQTKERSELSKEVVTL 309
+ +RQE K E L ++ E + +H+ E ++Q E +L +
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRR----- 1686
Query: 310 EQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHY 369
++ +++++ L RQ E ++ R + L+ + E ++ R+E ++ + ++ Y
Sbjct: 1687 QERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERY 1746
Query: 370 -KTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAE 428
K E +L E E+ +L+ + + R + ERE + LR + +E + E
Sbjct: 1747 RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQE 1806
Query: 429 KDALEKHDQLLD---RYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQC- 484
++ + Q D R+ E QL E + + L Q + + + +E QE++ R +
Sbjct: 1807 REEQQLRPQQRDGKYRWEEEQLQLEEQ-EQRLRQERDRQYRAEEQFATQEKSRREEQELW 1865
Query: 485 -QLECEKYQKKLEVLTKEFYSLQASSEKR---ITELQAQNSEHQARL 527
+ E ++ Q++ L +E Q E+R + E+++Q + RL
Sbjct: 1866 QEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRL 1912
Score = 93.6 bits (231), Expect = 6e-19
Identities = 156/701 (22%), Positives = 301/701 (42%), Gaps = 57/701 (8%)
Query: 3 RKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQL 62
R+ KE + + L+ + + + D + +ER R R +L +
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Query: 63 LKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALH----QKQLLTLRLDNQLAFQQKDA- 117
+ L K + + L+ + EE EE + Q+Q R + QL +++
Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 118 -SKYQELMKQEMETILLRQKQLEETNLQLR-EKAGDVRRNLRDFELTEEQYIKLKAFPED 175
+ ++ +QE E + K+L++ QL E+ RR R+ + EE+ ++ + E+
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE---EE 1001
Query: 176 QLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSE 235
QL E R E RK+ Q ++ +L EE K +L++ Y E+ + E
Sbjct: 1002 QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE--REKRRLQERERQYREEEELQQE 1059
Query: 236 VQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQ 295
+ Q L E ++ + YR+E ++++ E + L +E E RR+ E Q
Sbjct: 1060 EE---QLLGEERETRRRQELERQYRKE--EELQQEEEQLLREEPEKRRRQE-----RERQ 1109
Query: 296 TKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQL--EESKK 353
+E EL +E EQ LL++++E RQ +E R EE+ +++ + QL EE +K
Sbjct: 1110 CREEEELQQEE---EQ---LLREEREKRRRQELERQYR---EEEEVQQEEEQLLREEPEK 1160
Query: 354 AREEMYEKYVASRDHYKTEYENKLHDELE---QIRLKTNQEIDQLRNASREMYERENRNL 410
R + E+ + + E E L +E E Q R + +E ++L+ R+ R+
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 411 REARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERV 470
+ + EKE AV K + + +++R+L+ +S++ + Q L+ E+
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGREN--EQFRQLE---DSQLRDRQSQQDLQHLLGEQQ 1275
Query: 471 QLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIY 530
+ +E+ R Q + ++ KE S++ L+ + E + R +
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 531 EKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQ 590
K +E E ++Q E + ER ++ L++ L R+ E++
Sbjct: 1336 RKFREE--EQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQ----ERE 1389
Query: 591 NSLILKDLEHR-KDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQ 649
+ ++ + R +++ QL Q+ DR + QQ R ++RD K + + +
Sbjct: 1390 RKFLKEEQQLRCQEREQQLRQDRDR--KFREEEQQLSR------QERDRKFREEEQQVRR 1441
Query: 650 LEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQ 690
E++ L +E+ L Q +++ + EQLL REE +Q
Sbjct: 1442 QERERKFLEEEQQ-LRQERHRKFREEEQLLQEREEQQLHRQ 1481
Score = 85.1 bits (209), Expect = 2e-16
Identities = 147/718 (20%), Positives = 299/718 (41%), Gaps = 97/718 (13%)
Query: 38 EEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALH 97
EE+E + R T E ++L + EL ++ + L+ L + + EE+ L
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR 301
Query: 98 QKQLLTLRLDNQLAFQQKDASKYQELMKQEMETI--LLRQKQLEETNLQLREKAGDVRRN 155
++Q L + + + QQ++ + QE +Q+ E LR++Q E QLR + + RR
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361
Query: 156 LRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTN 215
+ EE+ + + E QL + + LR+E +L+ ++ + E+
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRRE-----QQLRREQ-QLRREQQLRREQQLRR 415
Query: 216 KNQLK---QLTETYEEDRKNYS-EVQIRCQRLALELADTKQLIQ---------------- 255
+ QL+ QL EE+R E + R QRL E + + ++
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475
Query: 256 ----QGDYRQENYDKVKSE--RDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTL 309
Q + R+E + K++ E R+ E+ +LRR+ E + + +E L + + +
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 310 EQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHY 369
+Q ++ +E L ++ E + E RL+R Q + + REE + R+
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE 595
Query: 370 KTEYENKLHDELEQI--------RLKTNQEIDQLRNASREMYERENRNLREARDNAVAEK 421
+ + +E+E++ RLK + ++ R + E+E R ++ R +
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 422 ERAVMAEKD---------------------ALEKHDQLLDRYR------ELQLSTESKVT 454
E+ + E++ A E+ +Q +R + + QL +E+
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 455 EFLHQSKLKSFESERVQLLQEETAR---NLTQCQLECEKYQKKLEVLTKEFYSLQASSEK 511
+ S+ + E +R + QEE R + Q Q E ++++ E + ++ Q +E+
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 512 RITELQAQNSEHQARLDIYEKLEKELDEIIMQTAE---IENEDEAERVLFSYGYGANVPT 568
+ + + S AR + E+ E++L Q E + E+E E
Sbjct: 776 KSERGRQRLS---ARPPLREQRERQLRAEERQQREQRFLPEEEEKE-------------- 818
Query: 569 TAKRRLKQSVHLARRVLQLEKQNSLILKD-LEHRKDQVTQLSQELDRANSLLNQTQQPYR 627
+R +Q + + LE++ L ++ + +++ L ++ +R S + Q +R
Sbjct: 819 ---QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 628 YLIESVRQRDSKIDSLTESI-AQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREE 684
+ +E R+R ++ QL K+ L +E+ L + + + EQ +REE
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREE 933
Score = 77.4 bits (189), Expect = 5e-14
Identities = 107/531 (20%), Positives = 217/531 (40%), Gaps = 46/531 (8%)
Query: 216 KNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKS------ 269
+ Q ++L E E+ K Q QR EL +Q Q+ + R+ ++++S
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 270 -----ERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLN 324
E +E++ELRRK + + ++R +E + T+L+K++E L
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 325 RQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQI 384
+ + EE++L +L+ Q ++ EE ++ + + + E + ++ E+
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 385 R----LKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLD 440
R + QE + + RE ER + LR R+ +E+ + E++ + QL
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLR--REQEEERREQQLRREQEEERREQQL-- 377
Query: 441 RYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTK 500
RE QL E ++ + + E+ QL +E+ R Q + E + +++ E
Sbjct: 378 -RREQQLRREQQLRREQQLRREQQLRREQ-QLRREQQLRREQQLRREQQLRREQEE---- 431
Query: 501 EFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSY 560
E + + E+R L+ + E + L E+ E+ E + +++ + E ER
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE--RRKQQLKRDQEEER----- 484
Query: 561 GYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLN 620
+R LK R Q E++ + ++ E R++Q + +E +R L
Sbjct: 485 ---------RERWLKLEEEERRE--QQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 621 QTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLN 680
QQ R E +R+ + E + E+ L +E+ + + Q
Sbjct: 534 SEQQLRR---EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRL 590
Query: 681 HREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHED 731
RE+ ++Q L + + E + + E ++ + L +E E+
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Score = 70.9 bits (172), Expect = 4e-12
Identities = 127/599 (21%), Positives = 248/599 (41%), Gaps = 90/599 (15%)
Query: 136 KQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLR 195
+QLE++ L+ R+ D++ L + + + + + + D+ PE + E R
Sbjct: 1251 RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDR-HFPEEEQLEREEQKEAKR 1309
Query: 196 KEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQ 255
++ + Q +K +L EE + + E DRK E Q+ +R E ++ +
Sbjct: 1310 RDR-KSQEEKQLLREEREEKRRR-------QETDRKFREEEQLLQER---EEQPLRRQER 1358
Query: 256 QGDYRQENYDKVKSERDALEQE--VIELRRKHEILEASHMIQTKERSELSKEVVTLEQTV 313
+R+E + R LE+E + R+ + L+ ++ +ER + ++
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ-----DRD 1413
Query: 314 TLLQKDKEYLNRQNMELSVRCAHEE-DRLERLQAQLEESKKAREEMYEKYVASRDHYKTE 372
+++++ L+RQ + R ++ R ER + LEE ++ R+E + K+ +
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473
Query: 373 YENKLHDE------LEQIRLKTNQEID-QLRNASREMYERENRNLREARDNAVAEKERAV 425
E +LH + LE+ + QE D + R E E + L E + +++R
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKF 1533
Query: 426 MAEKDALEK-----------------HDQLLDRYRELQLSTESKVTEF-LHQSKLKSFES 467
+ E+ L + +QL E QLS + + +F L + K++ E
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 468 ERVQLLQEETARNLT-QCQLECEKYQK--KLEVLTKEFYSLQASSEKR-------ITELQ 517
ER + E+ R Q QL E+ +K + E L +E Q ++R +L+
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Query: 518 AQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQS 577
Q E Q R D K +E E ++Q E + ER R+ ++
Sbjct: 1654 RQEREQQLRHDRDRKFREE--EQLLQEGEEQQLRRQER---------------DRKFREE 1696
Query: 578 VHLARRVLQ----LEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESV 633
RR + L+++ L ++LE + + QL QE ++ + Q+ YR ++E
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL---RRQERYRKILEEE 1753
Query: 634 RQRDSKIDSLTESIAQLEKD--------VSNLNKEKSALLQTKNQMALDLEQLLNHREE 684
+ R + + + + + E+D + +E+ Q ++ + EQL REE
Sbjct: 1754 QLRPEREE---QQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE 1809
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/513 (21%), Positives = 207/513 (40%), Gaps = 77/513 (15%)
Query: 249 DTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVT 308
D K+ + Q ++E+ + + LE+E + RR+ + + + +E+SE + +
Sbjct: 104 DGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ 163
Query: 309 LEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDH 368
++ Q+ E L RQ E R EE R E Q Q + + E E+ + R
Sbjct: 164 RDR-----QRRDEELWRQRQEWQER---EERRAEEEQLQSCKGHETEEFPDEEQLRRR-- 213
Query: 369 YKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAE 428
EL ++R K +E Q R ER++R +E + ++E + E
Sbjct: 214 -----------ELLELRRKGREEKQQQRR------ERQDRVFQEEEEKEWRKRETVLRKE 256
Query: 429 KDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLEC 488
++ L++ + R RELQ E +L+ E + ++ ++E + + + E
Sbjct: 257 EEKLQEEEP--QRQRELQEEEE----------QLRKLERQELRRERQEEEQQQQRLRREQ 304
Query: 489 EKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKEL---DEIIMQTA 545
+ +K+ E ++ + E+R E Q + E Q R + E+ E++L E +
Sbjct: 305 QLRRKQEEERREQQEERREQQERR--EQQEERREQQLRREQEERREQQLRREQEEERREQ 362
Query: 546 EIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSL-----ILKDLEH 600
++ E E ER + + R +Q + RR QL ++ L + ++ +
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQQLRREQQL 419
Query: 601 RKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRD-SKIDSLTE------SIAQLEKD 653
R++Q + QE +R Q ++ R E +RD K + TE QL++D
Sbjct: 420 RREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRD 479
Query: 654 VSNLNKEKSALL--------------QTKNQMALDLEQLLNHREELAAMKQILVK----M 695
+E+ L Q + + EQ L +EE ++Q L
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 696 HSKHSENSLLLTKTEPKHVTENQKSKTLNVPKE 728
+ LL + E K + + ++ + L +E
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQE 572
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 97.8 bits (242), Expect = 3e-20
Identities = 158/783 (20%), Positives = 321/783 (40%), Gaps = 69/783 (8%)
Query: 7 KESKKVNISSSLESEDISLETTVPTDDISSSEER-----EGKVRITRQLIERKELLHNIQ 61
+E ++ ++S + E D++L+ D+++ +EER + KV++ ++ E E L + +
Sbjct: 920 QELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEE 979
Query: 62 LLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDN---QLAFQQKDAS 118
+ +L+ + +++ + I++L+ L A +KQ ++ N ++A + +
Sbjct: 980 EVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVA 1039
Query: 119 KYQELMK--QEMETILLRQKQLEETNLQLREKAG-DVRRNLRDFELTEEQYIKLKAFPED 175
+ + K QE L Q EE + KA + + + D E + EQ KL+ E
Sbjct: 1040 RLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTER 1099
Query: 176 QLSIPEYVSVRFYELVNPLRKE-ICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYS 234
+ R E L +E + + K L E+L ++L QL+ E+++ +
Sbjct: 1100 --------AKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGA 1151
Query: 235 EVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMI 294
++Q + + L A ++L ++ + + +V+ +R +E+ EL + E +
Sbjct: 1152 QMQKKIKELQ---ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAG 1208
Query: 295 QT----KERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEE 350
Q K +EL + LE+ + L R+ E + + D L+R++ +LE+
Sbjct: 1209 QREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEK 1268
Query: 351 SKK----------AREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASR 400
K A E + AS + YE D+L + ++K + QL +AS
Sbjct: 1269 EKSELRMEVDDLAANVETLTRAKASAEKLCRTYE----DQLSEAKIKVEELQRQLADAST 1324
Query: 401 EMYERENRN-----LREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTE 455
+ + + L E ++ +++ R +LE+ + L+ + + + V
Sbjct: 1325 QRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQA 1384
Query: 456 FLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEV-LTKEFYSLQASSEKRIT 514
H L + E Q E R L++ E +++ K E + L+ + +K
Sbjct: 1385 LRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLAL 1444
Query: 515 ELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRL 574
LQ +A LEK ++ +QT + E ER T+A L
Sbjct: 1445 RLQEAEEGVEAANAKCSSLEKA--KLRLQTESEDVTLELERA-----------TSAAAAL 1491
Query: 575 -KQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESV 633
K+ HL R + + +Q + ++LE + + L EL R + + L
Sbjct: 1492 DKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKREN 1551
Query: 634 RQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILV 693
+ +I LT+ ++ K + L K K AL K+++ LE+ EL K + +
Sbjct: 1552 KNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEE-AEGALELEETKTLRI 1610
Query: 694 KMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQ 753
++ L K E + + N+ + H+ + + + +L + A + +
Sbjct: 1611 QL-------ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRL 1663
Query: 754 KMK 756
K K
Sbjct: 1664 KKK 1666
Score = 86.3 bits (212), Expect = 1e-16
Identities = 156/740 (21%), Positives = 300/740 (40%), Gaps = 103/740 (13%)
Query: 39 EREGKVRITRQLIERKELLHNIQLLKI---------ELSQKTMMIDNLKVDYLTKIEELE 89
+RE ++ R+ +E L H + + EL ++ + ++ + EL
Sbjct: 1215 KREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELR 1274
Query: 90 EKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEETNLQ---LR 146
+++D + LT A +K Y++ + + + Q+QL + + Q L+
Sbjct: 1275 MEVDDLAANVETLT----RAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQ 1330
Query: 147 EKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKN 206
++G++ R L + E Q + KA L LR+++ E K+
Sbjct: 1331 TESGELSRLLEEKECLISQLSRGKALAAQSLE--------------ELRRQLEEESKAKS 1376
Query: 207 ILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDK 266
LA + ++ L E +EE+ +E Q QRL L A+ + + Y + +
Sbjct: 1377 ALAHAVQALRHDCDLLREQHEEE----AEAQAELQRL-LSKANAEVAQWRSKYEADAIQR 1431
Query: 267 VKSERDALEQEVIELRRKHEILEA-----SHMIQTKERSELSKEVVTLE-----QTVTLL 316
+ +A ++ + L+ E +EA S + + K R + E VTLE L
Sbjct: 1432 TEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAAL 1491
Query: 317 QKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMY------EKYVASRDHYK 370
K + +L R L R EE+ L+A ES+ E++ E+ + + + K
Sbjct: 1492 DKKQRHLERA---LEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLK 1548
Query: 371 TEYEN---KLHDELEQIRL--KTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAV 425
E +N ++ D +Q+ L K+ QE+++ + A L EA E+ + +
Sbjct: 1549 RENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTL 1608
Query: 426 MAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQ 485
+ + L + +DR +L+ + + L ++ ++ ES + L E ARN
Sbjct: 1609 RIQLE-LSQVKAEVDR----KLAEKDEECANLRRNHQRAVESLQASLDAETRARN----- 1658
Query: 486 LECEKYQKKLEVLTKEFYSLQASSEKRITE-------LQAQNSEHQARLDIYEKLEKELD 538
E + +KK+E + + ++ TE +QAQ E QA D ++L EL
Sbjct: 1659 -EALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELH 1717
Query: 539 EIIMQTAEIENED-----EAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSL 593
E Q +E E E + + G A++ L ++ R+ L QN+
Sbjct: 1718 E---QAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATE---RLNLLHSQNTG 1771
Query: 594 ILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKD 653
+L + + + QLS E++ A Q R E ++ + + E + + +
Sbjct: 1772 LLNQKKKLEADLAQLSGEVEEA-------AQERREAEEKAKKAITDAAMMAEELKKEQDT 1824
Query: 654 VSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKH 713
++L + K L QT ++ LE+ + L K+ + K+ +K E L + KH
Sbjct: 1825 SAHLERMKKTLEQTVRELQARLEEA--EQAALRGGKKQVQKLEAKVRELEAELDAEQKKH 1882
Query: 714 VTENQKSKTLNVPKEHEDNI 733
++ L ++HE +
Sbjct: 1883 ------AEALKGVRKHERRV 1896
Score = 36.6 bits (83), Expect = 0.089
Identities = 58/268 (21%), Positives = 108/268 (40%), Gaps = 45/268 (16%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMM 73
+++ LE +LE + ++ E E R+ + LL+ + L+ +L+Q +
Sbjct: 1730 LAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGE 1789
Query: 74 IDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEME-TIL 132
++ + E EEK A+ ++ L +++D S + E MK+ +E T+
Sbjct: 1790 VEEAAQER----REAEEKAKKAITDAAMMAEELK-----KEQDTSAHLERMKKTLEQTVR 1840
Query: 133 LRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVN 192
Q +LEE Q + G ++Q KL+A V
Sbjct: 1841 ELQARLEEAE-QAALRGG------------KKQVQKLEA------------------KVR 1869
Query: 193 PLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQ 252
L E+ Q K + + ++ ++K+L EEDRKN + +Q +L ++ K+
Sbjct: 1870 ELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKR 1929
Query: 253 LI----QQGDYRQENYDKVKSERDALEQ 276
QQ + Y K + E D E+
Sbjct: 1930 QFEEAEQQANTNLAKYRKAQHELDDAEE 1957
>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
Length = 1710
Score = 97.1 bits (240), Expect = 6e-20
Identities = 154/696 (22%), Positives = 296/696 (42%), Gaps = 118/696 (16%)
Query: 84 KIEELEEKLNDALHQK-QLLTLRLDNQLAFQQK--DASKYQELMKQEMETI-----LLRQ 135
++E +L A+H + Q T + + +LAFQ+ + S+ Q+ M ++ + +L Q
Sbjct: 1005 EVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQ 1064
Query: 136 K-------------QLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKA-FPEDQLSIPE 181
+ + T LREK + R +D T+ Q +++ + +Q+ + +
Sbjct: 1065 QLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNK 1124
Query: 182 YVSVRFYELVNPLRKEICELQVKKNILAEELST--NKNQLKQLTETYEEDRKN--YSEVQ 237
Y+ + + + + +LQ + +L ++L NK K+ T +D+ + ++Q
Sbjct: 1125 YIGKQ-----ESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQ 1179
Query: 238 IRCQRLALELAD-TKQLIQQGDY---RQENYDKVKSERDA----LEQEVIELRRKHEILE 289
++ +L L + K+LI + ++ RQ Y+ K+ER+ L+QE+ + +K + E
Sbjct: 1180 AESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSE 1239
Query: 290 ASHMIQTKERSELSKEVVTLEQTV---------------------TLLQKDKEYLNRQNM 328
AS + ++ R L E L++ + +Q K+ L + N
Sbjct: 1240 ASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNA 1299
Query: 329 ELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKT 388
+L V + D++E LQ L + + +E ++ + K E L E+++ ++
Sbjct: 1300 KLKVTVKKQMDKIEELQKNLLNANLSEDE--KEQLKKLMELKQSLECNLDQEMKK-NVEL 1356
Query: 389 NQEIDQLRN----ASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRE 444
+EI +N +++ E EN D ++ E + K L + +
Sbjct: 1357 EREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINK--------LKHKIDD 1408
Query: 445 LQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYS 504
L E+ ++ LH + Q+LQEE ++ Q +CEK QK + L +E +
Sbjct: 1409 LTAELETAGSKCLHL-------DTKNQILQEELL-SMKTVQKKCEKLQKNKKKLEQEVIN 1460
Query: 505 LQASSEKRITEL-----QAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFS 559
L++ E+ + EL Q E +AR +I EKL++ + Q A EN ++ F
Sbjct: 1461 LRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQ-----FR 1515
Query: 560 YGYGANVPTTAKRRLKQSVHLARRV---------LQLEKQNSLILKDLEHRKDQVTQLSQ 610
A++ + + R+K ++ +LEK L L++L+ RK LS
Sbjct: 1516 ENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRK----SLSS 1571
Query: 611 ELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQ 670
+L + N L + + L+E + R S +LT V NLN N+
Sbjct: 1572 KLTKTNERLAEVNT--KLLVEKQQSR-SLFTTLTTRPVMEPPCVGNLNNSLDL-----NR 1623
Query: 671 MALDLEQLL----NHREELAAMKQILVKMHSKHSEN 702
+ E L+ N R +M+ L KM + +N
Sbjct: 1624 KLIPRENLVISTSNPRASNNSMENYLSKMQQELEKN 1659
Score = 87.8 bits (216), Expect = 3e-17
Identities = 154/751 (20%), Positives = 308/751 (41%), Gaps = 102/751 (13%)
Query: 32 DDISSSEEREGKVRITRQLIERKELLHNIQLLKIELSQKTMMIDNLKVDYLTKIEELEEK 91
DD S SE E + R T++ K + N Q M D VD LT+ E +
Sbjct: 649 DDSSLSEIDEDEGRPTKKTSNEKNKVKN---------QIQSMDD---VDDLTQSSETASE 696
Query: 92 LNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETI-LLRQKQLEETNLQLREKAG 150
+ H + L QL + KD+ ++ + LL K+ L ++ K
Sbjct: 697 DCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKM 756
Query: 151 DVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAE 210
+ + N+ EL+E + IK + E+ V + + LR + + + K+
Sbjct: 757 EDKVNVLQRELSETKEIKSQL---------EHQKVEWERELCSLRFSLNQEEEKRRNADT 807
Query: 211 ELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTK----QLIQQGDYRQENYDK 266
+ QL++ E Y ++ + ++++ Q L +EL K Q++Q+ + Q +
Sbjct: 808 LYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSR 867
Query: 267 VKSER---DAL------EQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQ 317
++ R D + +Q+ IE+ +K E SH +E +LS + L++ + +L+
Sbjct: 868 EQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSH--SHEEEKDLSHKNSMLQEEIAMLR 925
Query: 318 KDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKL 377
+ + + QN E +C + ++ L+++ K EE + + ++Y +L
Sbjct: 926 LEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTI-------SQYNGRL 978
Query: 378 -----HDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDAL 432
+ + +L+ ++ + A E Y RD + K +A + A
Sbjct: 979 SVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRAR 1038
Query: 433 EKHDQLLDR--YRELQLSTESKVTE---FLHQSKLKSFESE---RVQLLQEETA------ 478
++ +L D+ + L +++ F +SKL S E E L+E+T
Sbjct: 1039 DECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQ 1098
Query: 479 --RNLTQCQL-ECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARL-DIYEKLE 534
+ TQCQ+ E E+ + +V ++ Q S E+R+++LQ++N + +L D + K +
Sbjct: 1099 KDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKAD 1158
Query: 535 KELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLI 594
+ +I I+++ + A V KQS L LE++N +
Sbjct: 1159 NKEKTVI----NIQDQ-----------FHAIVQKLQAESEKQS-------LLLEERNKEL 1196
Query: 595 LKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDV 654
+ + H K++ Q E ++ Q QQ ++ ++ ++ + LE +
Sbjct: 1197 ISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDET 1256
Query: 655 SNLNKEKSALLQTKNQMALD--------LEQLLNHREEL----AAMKQILVKMHSKHSEN 702
+L K+K ++ + Q A D E++ +H+++L A +K + K K E
Sbjct: 1257 QDL-KKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEEL 1315
Query: 703 SLLLTKTEPKHVTENQKSKTLNVPKEHEDNI 733
L + Q K + + + E N+
Sbjct: 1316 QKNLLNANLSEDEKEQLKKLMELKQSLECNL 1346
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 96.3 bits (238), Expect = 9e-20
Identities = 165/779 (21%), Positives = 322/779 (41%), Gaps = 136/779 (17%)
Query: 8 ESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRI-------TRQLIERKELLHN- 59
E K N + LE++++ ++ + S SE K + + L+E+KEL
Sbjct: 863 EMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRR 922
Query: 60 --IQLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQ-----KQLLTLRLDNQLAF 112
+ LLK L++ ++K D L+ ++ELEEK+ + + +++ ++L A
Sbjct: 923 AELILLKDSLAKSP----SVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAK 978
Query: 113 QQKDASKYQ-ELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKA 171
++ D+S+ + + +K+E+E++ + QL + L + A + L ++E EQ K
Sbjct: 979 KELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
Query: 172 FPE------DQLSIPEYVSVRFYELVNP------------------LRKEICELQVKKNI 207
+ L+ S E +N L +I E+Q K +
Sbjct: 1039 RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAM 1098
Query: 208 LAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQ--QGDYRQ---- 261
+ +EL K Q +Q + + E+Q++ Q+ +L T Q ++ + D +Q
Sbjct: 1099 VDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM 1158
Query: 262 ----ENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQ 317
+Y+++ E L Q++ K E LE IQ +++ L +E+ +L+ +V +
Sbjct: 1159 NMEIADYERLMKE---LNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYE 1215
Query: 318 ----KDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVAS-------- 365
K K+ L + EL+ E D L LQA L+ +A ++ E Y
Sbjct: 1216 EKNTKIKQLLVKTKKELADSKQAETDHL-ILQASLKGELEASQQQVEVYKIQLAEITSEK 1274
Query: 366 ---RDHYKTEYEN---------------------------KLHDELEQIRLKTNQEIDQL 395
+H KT E + E E +++ + + Q
Sbjct: 1275 HKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQ 1334
Query: 396 RNASREMYEREN-RNLREARDNAVAEKERAVMAEKDALE-----------KHDQLLDRYR 443
+N S E E + RE + + + + + ++ L+ +HD LL+R+
Sbjct: 1335 KNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHN 1394
Query: 444 ELQLSTESKVTEFLHQSKLKSFESERVQL------------LQEETARNLTQCQLE--CE 489
++ T SK E + KL S +SE + + Q E RN + Q+ E
Sbjct: 1395 KMLQETVSKEAEL--REKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQE 1452
Query: 490 KYQKKLEVLTKEFYSLQAS--SEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEI 547
+++K +E L ++ ++A K ++ S Q+ ++ E+ +L + M T
Sbjct: 1453 EHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV-- 1510
Query: 548 ENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQ 607
+E E + + + +T + L+Q ++ L+ ++ K E +++
Sbjct: 1511 -TREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTK--EELVQKLSS 1567
Query: 608 LSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQ 666
++ D N LL +T+ L+E ++ S+I L E + EK +NL K+ LLQ
Sbjct: 1568 TTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRL-ERNQEREKSAANLEYLKNVLLQ 1625
Score = 84.0 bits (206), Expect = 5e-16
Identities = 173/795 (21%), Positives = 331/795 (41%), Gaps = 74/795 (9%)
Query: 7 KESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNI-QLLKI 65
KE ++N + +SE L T+ + E+ E + ++ I E L I ++L+
Sbjct: 435 KEISELNETFLSDSEKEKL--TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQT 492
Query: 66 ELSQKTMMI----DNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQ 121
EL + I +++K + + EL++KL A +K L L N+L + + Q
Sbjct: 493 ELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDAL-LETVNRLQGENEKLLSQQ 551
Query: 122 ELMKQEMETILLRQKQ-------LEETNLQLREKAGDVRRNLRDFELTEEQ---YIKLKA 171
EL+ + TI Q++ L + + L+E G + LTEE+ KLK
Sbjct: 552 ELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKIN------SLTEEKDDFINKLKN 605
Query: 172 FPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQ-LTETYEEDR 230
E+ + + R L+ L K++ E ++ N EL N+L L ET +E
Sbjct: 606 SHEEMDNFHKKCE-REERLILELGKKV-EQTIQYN---SELEQKVNELTGGLEETLKEKD 660
Query: 231 KNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEV-IELRRKHEILE 289
+N +++ ++ + D + L + E +K+ SE+ L +++ + L +K +++
Sbjct: 661 QNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL 720
Query: 290 ASHMIQTKERSELSKE-------VVTLEQTVTLLQKDKEY--LNRQNMELSVRCAHEEDR 340
H+ Q +++ +L E ++ EQ L K + Y L E+S + E+D
Sbjct: 721 KEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVS-EDSEEKDV 779
Query: 341 LERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASR 400
+ LQA E K EE RD E E E++ ++ ++ + ++L++ R
Sbjct: 780 VNVLQAVGESLAKINEEKCN-LAFQRDEKVLELEK----EIKCLQEESVVQCEELKSLLR 834
Query: 401 EMYERENRNLREARDNAVAEKERAVMA--------EKDALEKHDQLLDRYRELQLSTESK 452
+ YE+E LR+ + +EKE EK LE + L+ Q ++S+
Sbjct: 835 D-YEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSE 893
Query: 453 VTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKR 512
+ + +K E+ + L Q+E + L + K V S++ EK
Sbjct: 894 IHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEK- 952
Query: 513 ITELQAQNSEHQARLD----IYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPT 568
I L+ + E + +++ + K +KELD +T ++ E E+ R +
Sbjct: 953 IENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLR-----SEKDQLSA 1007
Query: 569 TAKRRLKQSVHLARRVLQLEKQNSLI------LKDLEHRKDQVTQLSQELDRANSLLNQT 622
+ + ++ + +L+ EKQ+ + + EHR + +T+ + +N
Sbjct: 1008 SMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSD 1067
Query: 623 QQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHR 682
+ IE++ Q ++K+ L I ++++ + ++KE A K Q + +N
Sbjct: 1068 NEDLLARIETL-QSNAKL--LEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNEL 1124
Query: 683 EELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTPKPTLFT 742
EEL Q K K + L+ K + N + + + T K
Sbjct: 1125 EELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIE 1184
Query: 743 KKEAPEWSKKQKMKT 757
E +KQK +T
Sbjct: 1185 DLEQEIKIQKQKQET 1199
Score = 79.3 bits (194), Expect = 1e-14
Identities = 160/753 (21%), Positives = 303/753 (40%), Gaps = 141/753 (18%)
Query: 38 EEREGKVRITRQLIERKELLHNIQLLKIELS-----------QKTMMIDNLKVDYLTKIE 86
E + + +I L+ ++E I+ LK EL+ Q + +LK + +I
Sbjct: 379 EREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEIS 438
Query: 87 ELEEK-LNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEET---- 141
EL E L+D+ +K+ LTL F+ + + E ++QE + +L + L E
Sbjct: 439 ELNETFLSDS--EKEKLTLM------FEIQGLKEQCENLQQEKQEAILNYESLREIMEIL 490
Query: 142 NLQLREKAGDVRRNLRDFELTEEQYI-----KLKAFPEDQLSIPEYVS---------VRF 187
+L E AG + + + + + KL+ ++ ++ E V+ +
Sbjct: 491 QTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQ 550
Query: 188 YELVNPLRKEICELQVKKNILAEELSTNKNQLKQLT-----------------ETYEEDR 230
ELV L I LQ K + LS LK+L + E+
Sbjct: 551 QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEM 610
Query: 231 KNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEA 290
N+ + R +RL LEL K++ Q Y E KV LE+ + E + + LE
Sbjct: 611 DNFHKKCEREERLILELG--KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK 668
Query: 291 SHMIQTKERSE----LSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQA 346
M+Q K SE LS EV +L + L +K+ L+R +L V + +ED +
Sbjct: 669 L-MVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSR---DLEVFLSQKEDVI----- 719
Query: 347 QLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERE 406
L+E E+ + V +D+ EN ++++++ +KT QL +EM
Sbjct: 720 -LKEHITQLEKKLQLMVEEQDNLNKLLEN---EQVQKLFVKT-----QLYGFLKEM---- 766
Query: 407 NRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFE 466
+ D+ + + A ++L K ++ E F K+ E
Sbjct: 767 --GSEVSEDSEEKDVVNVLQAVGESLAK------------INEEKCNLAFQRDEKVLELE 812
Query: 467 SERVQLLQEETARNLTQCQLECEKYQKKLE-------VLTKEFYSLQASSEKRITE-LQA 518
E ++ LQEE+ ++CE+ + L +L KE +Q+ E ++ L+
Sbjct: 813 KE-IKCLQEESV-------VQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEM 864
Query: 519 QNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSV 578
+N+ + RL+ + L +++E+ ++ E +E E+ +K+
Sbjct: 865 KNANEKTRLE-NQNLLIQVEEVSQTCSKSEIHNEKEKCF----------------IKEHE 907
Query: 579 HLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDS 638
+L + Q K+L R+ ++ L L ++ S+ N + L E + +
Sbjct: 908 NLKPLLEQ---------KELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEK 958
Query: 639 KIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSK 698
+ E I +++ KE + + + +LE L + +++L+A + L++
Sbjct: 959 ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQ--GA 1016
Query: 699 HSENSLLLTKTEPKHVTENQKSKTLNVPKEHED 731
S +LLL + + +K + N ED
Sbjct: 1017 ESYKNLLLEYEKQSEQLDVEKERANNFEHRIED 1049
Score = 79.0 bits (193), Expect = 2e-14
Identities = 140/651 (21%), Positives = 263/651 (40%), Gaps = 107/651 (16%)
Query: 115 KDASKYQELMKQEMETILLRQKQLEETNLQ-LREKAGDVRRNLRDF--------ELTEEQ 165
K A K L+++ +K++EE + + E GD+ + L + TE+Q
Sbjct: 32 KFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQ 91
Query: 166 YIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTET 225
+ LK ++ + + + V + V + EL+ +E+ KN+L +
Sbjct: 92 CLSLK---KENIKMKQEVE----DSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSK 144
Query: 226 YEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSE----RDALEQEVIEL 281
Y ED+ N + LEL++ QL Q + ++N K++ E R E++++ L
Sbjct: 145 YSEDKANLQKQLEEAMNTQLELSE--QLKFQNN-SEDNVKKLQEEIEKIRPGFEEQILYL 201
Query: 282 RRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRL 341
+++ L+A+ T E+ E TVT LQ + H + +
Sbjct: 202 QKQ---LDAT----TDEKKE----------TVTQLQN----------IIEANSQHYQKNI 234
Query: 342 ERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASRE 401
LQ +L + K +E ++ + + E+E ++ ++L +++ ++ + ++
Sbjct: 235 NSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEI-NKLNELKENLVKQCEASEKNIQK 293
Query: 402 MYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSK 461
YE E NLR+A NA + + + LL ++ KV +
Sbjct: 294 KYECELENLRKATSNANQDNQICSI-----------LLQENTFVEQVVNEKVKHL--EDT 340
Query: 462 LKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNS 521
LK ES+ L E T N + +LE + K EF+ + E +I EL
Sbjct: 341 LKELESQHSILKDEVTYMNNLKLKLEMDAQHIK-----DEFFHEREDLEFKINELLLAKE 395
Query: 522 EHQARLDIYEKLEKELDEIIMQ---TAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSV 578
E + EKL+ EL + Q T E N + V + ++ K+
Sbjct: 396 EQGC---VIEKLKSELAGLNKQFCYTVEQHNRE--------------VQSLKEQHQKEIS 438
Query: 579 HLARRVL-QLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRD 637
L L EK+ ++ +++ K+Q L QE A ++ L + +
Sbjct: 439 ELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESA 498
Query: 638 SKIDSLTESIAQLE-KDVSNLNK-------EKSALLQTKNQMALDLEQLLNHREELAAMK 689
KI ES+ Q + DV L + EK ALL+T N++ + E+LL+ +E + ++
Sbjct: 499 GKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELE 558
Query: 690 QILVKMHSKH-------SENSLLLTKTEPK--HVTENQKSKTLNVPKEHED 731
+ + K+ S+ +L + E K +TE + + HE+
Sbjct: 559 NTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEE 609
Score = 75.9 bits (185), Expect = 1e-13
Identities = 153/744 (20%), Positives = 324/744 (43%), Gaps = 108/744 (14%)
Query: 65 IELSQKTMMIDNLKVDYLTKIE-ELEEKLNDALHQK-----QLLTLRLDNQLAFQQKDAS 118
I+ ++K MM+ T++E E+EE + + + + LT RLD A + A
Sbjct: 31 IKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLD---ALLLEKAE 87
Query: 119 KYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLS 178
Q+ + + E I ++Q+ + K GD + L E + Y+K +++L
Sbjct: 88 TEQQCLSLKKENIKMKQEVEDSVT-----KMGDAHKEL---EQSHINYVKEIENLKNELM 139
Query: 179 IPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQ---LKQLTETYEEDRKNYSE 235
V ++ E L+K++ E + L+E+L N +K+L E E+ R + E
Sbjct: 140 A---VRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEE 196
Query: 236 VQIRCQRLALELADTKQ--LIQQGDYRQENYDKVKSERDALEQEVIELRRKHEI------ 287
+ Q+ D K+ + Q + + N + ++L++E+++L+ H+
Sbjct: 197 QILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELM 256
Query: 288 --LEAS---HMIQTKERSELSKEVVT-LEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRL 341
+EAS H + + +EL + +V E + +QK E +N+ + A++++++
Sbjct: 257 CQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYE-CELENLRKATSNANQDNQI 315
Query: 342 ERLQAQLEESKKAREEMYEKYVASRDHYKTEYENK---LHDELEQIR-LKTNQEIDQLRN 397
L+E+ + + EK D K E E++ L DE+ + LK E+D
Sbjct: 316 --CSILLQENTFVEQVVNEKVKHLEDTLK-ELESQHSILKDEVTYMNNLKLKLEMDAQHI 372
Query: 398 ASREMYERENRN-------LREARDNAVAEKERAVMAEKD-----ALEKHDQLLDRYREL 445
+ERE+ L + V EK ++ +A + +E+H++ + +E
Sbjct: 373 KDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQ 432
Query: 446 QLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSL 505
+ +++E L+++ L E E++ L+ E + + +CE Q++ + + SL
Sbjct: 433 H---QKEISE-LNETFLSDSEKEKLTLMFE-----IQGLKEQCENLQQEKQEAILNYESL 483
Query: 506 QASSEKRITEL---------QAQNSEHQARLDIYEKLEKELDEIIMQTAEIEN----EDE 552
+ E TEL + ++ + Q D++E +K + A +E + E
Sbjct: 484 REIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGE 543
Query: 553 AERVLFSYGYGANVPTTAKRRLKQS----VHLARRVLQLEKQNSLILKDLEHRKDQVTQL 608
E++L + T K +++ + L++R L++ I E + D + +L
Sbjct: 544 NEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKL 603
Query: 609 SQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTK 668
+ ++ + ++ R ++E + K++ + ++LE+ V+ L L+ K
Sbjct: 604 KNSHEEMDNFHKKCEREERLILELGK----KVEQTIQYNSELEQKVNELTGGLEETLKEK 659
Query: 669 NQMALDLEQLLNHREELAAMKQIL-VKMHSKHSENSLLLTKTE----------------- 710
+Q LE+L+ + L+ K++L ++ S + EN+ L ++ +
Sbjct: 660 DQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI 719
Query: 711 -PKHVTENQKSKTLNVPKEHEDNI 733
+H+T+ +K L V E +DN+
Sbjct: 720 LKEHITQLEKKLQLMV--EEQDNL 741
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 96.3 bits (238), Expect = 9e-20
Identities = 164/779 (21%), Positives = 343/779 (44%), Gaps = 106/779 (13%)
Query: 14 ISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKI--ELSQKT 71
+ SL+ E L++ + D ++ + + + ++R + +++ + N KI E+S+
Sbjct: 937 LQESLQIERDQLKSDIH-DTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNL 995
Query: 72 MMIDNL---KVDYLTKIEELEEKLNDALHQKQLLTLRL-DNQLAFQQKDASKYQELMKQE 127
M +N K ++ K+ +++K + Q LT + DN++ QQ+ K L++++
Sbjct: 996 HMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQR---KIFSLIQEK 1052
Query: 128 METILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRF 187
E Q+ LE + + D++ N+ E+T E +L+ ++ E V+
Sbjct: 1053 NEL----QQMLESVIAEKEQLKTDLKENI---EMTIENQEELRLLGDELKKQQEIVA--- 1102
Query: 188 YELVNPLRKE---------ICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQ- 237
E + ++KE + E++ K +++L + QL + E E +K +E++
Sbjct: 1103 QEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIEN 1162
Query: 238 ----IRCQRLALELADTKQLIQQGDYRQENYDKVKS---ERDALE--QEVIELRRKH--- 285
++ + L LE +T++L + ENY++VKS ER L+ Q+ E R H
Sbjct: 1163 LKNELKNKELTLEHMETERL-ELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1221
Query: 286 --EILEASHMIQTKERSELSK-EVVTLEQTVTLL-----QKDKEYLNRQNMELS------ 331
+EA+ + QTKE +++ + ++T+ L +K + +N Q++E S
Sbjct: 1222 YIREIEATGL-QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE 1280
Query: 332 -VRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQ 390
+ HEE + L ++E + +E M E + + + E+E++RL
Sbjct: 1281 EIPVLHEE---QELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRL---- 1333
Query: 391 EIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALE-KHDQLLDRYRELQLST 449
N + + E ++L + RDN KE ALE KHDQL + RE
Sbjct: 1334 ------NEKFQESQEEIKSLTKERDNLKTIKE--------ALEVKHDQLKEHIRETLAKI 1379
Query: 450 ESKVTEFLHQSKLKSFESERVQLLQE-ETARNLTQCQLECEKYQKKLEVLTKEFYSLQAS 508
+ ++ +K ++E +++ E E + L E L +E + S
Sbjct: 1380 QESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKS 1439
Query: 509 SEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENE--------DEAERVLFSY 560
K +LQ Q+ D +L++ + EI+ + E E E E E +
Sbjct: 1440 VAKEKDDLQRLQEVLQSESD---QLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496
Query: 561 GYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQ--VTQLSQELDRANSL 618
+ T +++ + LQ + ++++ +++Q + Q+S+ ++ N L
Sbjct: 1497 RVNLSEKETEISTIQKQLEAINDKLQNK------IQEIYEKEEQFNIKQISEVQEKVNEL 1550
Query: 619 LNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLEQL 678
Q ++ + +++ +SK+ LT + + ++++ + KEK + + + + ++ +QL
Sbjct: 1551 -KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQL 1609
Query: 679 L-NHREELAAMKQILVKMH---SKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNI 733
N +E +A MK+ K + + N E +H+ E +++ LN+ +NI
Sbjct: 1610 KENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI 1668
Score = 93.6 bits (231), Expect = 6e-19
Identities = 160/763 (20%), Positives = 311/763 (40%), Gaps = 125/763 (16%)
Query: 4 KISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLL 63
K +E K+V + +E + + T + S+E+E + + E +E + I+ L
Sbjct: 1590 KEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHL 1649
Query: 64 KIELSQKTMMIDNLKVD--YLTKI--EELEE------KLNDALHQKQLLTLRLD----NQ 109
K + + + ++N++ + LT+I E LEE + +D ++ L + D N
Sbjct: 1650 KEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENL 1709
Query: 110 LAFQQKDASKYQEL------MKQEMETI-----LLRQKQLEETNLQLREKAGDVRRNLRD 158
+D K +EL +K+ ETI ++ +K E +N+Q + + +D
Sbjct: 1710 RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQD 1769
Query: 159 FELTEEQYIKLKAFPEDQLSIPE---YVSVRFYELVNPLRKEICELQVKKNILAEELSTN 215
++ EE I E Q +I + VS + +L N ++K++ K +EL N
Sbjct: 1770 LKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSN-MQKDLENSNAKLQEKIQELKAN 1828
Query: 216 KNQLKQLTETYEEDRKNYSEV-----QIRCQRLAL----------------ELADTKQLI 254
++QL L + E +K SE+ QI+ Q L L L + K ++
Sbjct: 1829 EHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVM 1888
Query: 255 QQGDYRQENYDKVKSERDALEQEVIELRRK----HEILEASHMIQ-------TKERSELS 303
++ D + + +K ERD L++ + E + + + L+ + M+ K R ++S
Sbjct: 1889 KERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKIS 1948
Query: 304 KEVVTLEQTVTLLQKDKEYLNR-----QNMELSVRCAHEEDRLERLQAQLEESKKAREEM 358
++ + + L K K+ L + Q EL + E+ + + E K + E
Sbjct: 1949 EKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEA 2008
Query: 359 YEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAV 418
+ S + KLH+ LE+IR+ +E D+LR R +L+ RD +
Sbjct: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIRI-VAKERDELR--------RIKESLKMERDQFI 2059
Query: 419 AEKERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQ--SKLKSFESERVQLLQEE 476
A + E A ++ + + + L + +TE L + S++K ++
Sbjct: 2060 -----ATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHY 2114
Query: 477 TARNLTQCQLECE-KYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEK 535
N LE E ++QK+L + K SL K I +L N + ++ K
Sbjct: 2115 ECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSME---FHRIMK 2171
Query: 536 ELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLIL 595
+L ++ +I+ E F + + ++EKQ L++
Sbjct: 2172 KLKYVLSYVTKIKEEQHESINKFEMDF---------------------IDEVEKQKELLI 2210
Query: 596 KDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVS 655
K ++H + S+EL + LNQ D I+ + + + E +
Sbjct: 2211 K-IQHLQQDCDVPSREL--RDLKLNQNM-------------DLHIEEILKDFS--ESEFP 2252
Query: 656 NLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSK 698
++ E +L + +M LE+ LN R ++ +K + K + +
Sbjct: 2253 SIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDR 2295
Score = 89.7 bits (221), Expect = 9e-18
Identities = 156/792 (19%), Positives = 332/792 (41%), Gaps = 113/792 (14%)
Query: 21 EDISLETTVPTDDISSSEEREGKVR--ITRQLIERKELLHNIQLLKIELSQKTMMIDNLK 78
E + LE + + ++ R+ +++ + + KE + L+ ++S+KT+ I +++
Sbjct: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQ 1958
Query: 79 VDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQL 138
D +EL++K+ + L +K+L LR+ + K ++ ++L KQ E L + +
Sbjct: 1959 KDLDKSKDELQKKIQE-LQKKELQLLRVKEDVNMSHKKINEMEQLKKQ-FEAQNLSMQSV 2016
Query: 139 EETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLS-IPEYVSVRFYELVNPLRKE 197
N QL +K E EE I++ A D+L I E + + + + LR+
Sbjct: 2017 RMDNFQLTKKL---------HESLEE--IRIVAKERDELRRIKESLKMERDQFIATLREM 2065
Query: 198 IC------ELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQ---RLALELA 248
I +++ +K +L++ L++ +E K YSE+ + RL+L+L
Sbjct: 2066 IARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE 2125
Query: 249 DTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVT 308
++ ++++E +VK+ L ++ + ++ A+ + + K
Sbjct: 2126 ------KEIEFQKELSMRVKAN---LSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYV 2176
Query: 309 LEQTVTLLQKDKEYLNRQNM----------ELSVRCAHEEDRLERLQAQLEESKKAR--- 355
L + ++ E +N+ M EL ++ H + + +L + K +
Sbjct: 2177 LSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMD 2236
Query: 356 ---EEMYEKYVASR-DHYKTEYENKLHDELEQIR-----LKTNQEIDQLRNASREMYER- 405
EE+ + + S KTE++ L + E + L T +I++L+N ++ +R
Sbjct: 2237 LHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRI 2296
Query: 406 -------ENRNLREARDNAVAEKERAVMAE------KDALEKHDQLLDRYRELQLSTES- 451
NR + ++ E+ A +++ K EK+++L Y+ L+ S S
Sbjct: 2297 CQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASG 2356
Query: 452 -KVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSE 510
+V +K S QL E+ +LE ++ K + KE ++ E
Sbjct: 2357 AQVNPTTQDNKNPHVTSRATQLTTEKIR------ELENSLHEAKESAMHKESKIIKMQKE 2410
Query: 511 KRITELQAQNSEHQARLDIYEKLEKELDE---IIMQTAEIENEDEAERVLFSYGYGANVP 567
+T DI KL+ ++ E + +T E + + L + Y +
Sbjct: 2411 LEVTN------------DIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIE 2458
Query: 568 TTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRAN-----SLLNQ- 621
+ +K + + + EK+ S +E++K+ + L + L R+ S++++
Sbjct: 2459 DLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEH 2518
Query: 622 -----TQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQMALDLE 676
+ +P S +++K L +LEK++S L ++ L++ KN++ + +
Sbjct: 2519 TDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQ 2578
Query: 677 QLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKSKTLNVPKEHEDNIFTP 736
L N E+ K+ +K + H + + + PK K K + + E N+ P
Sbjct: 2579 HLSN---EVKTWKERTLKREA-HKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDP 2634
Query: 737 KPTLFTKKEAPE 748
P KE+P+
Sbjct: 2635 VP-----KESPK 2641
Score = 77.8 bits (190), Expect = 3e-14
Identities = 122/631 (19%), Positives = 277/631 (43%), Gaps = 63/631 (9%)
Query: 81 YLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKYQELMKQEMETILLRQKQLEE 140
Y +I +L+++L + + + + D QLA ++ Q++ +++E L + +
Sbjct: 348 YRKEIMDLKKQLEEVSLETRAQAMEKD-QLAQLLEEKDLLQKVQNEKIEN--LTRMLVTS 404
Query: 141 TNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICE 200
++L L+++ R+ + L + +K + DQ +IP ++ + ++L L +EI E
Sbjct: 405 SSLTLQQELKAKRKRRVTWCLGKINKMKNSNYA-DQFNIPTNITTKTHKLSINLLREIDE 463
Query: 201 LQVKKNILAEELSTNKNQLKQLTET-YEEDRKNYSEVQIRCQRLALELADTKQLIQQGDY 259
+ E N L L+E + K ++ I + +L AD L+
Sbjct: 464 S------VCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLR-ADYDNLVL---- 512
Query: 260 RQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKD 319
+Y+++++E++ +E ++L+ K+++ E + + ++ + + + + L++
Sbjct: 513 ---DYEQLRTEKEEME---LKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHA 566
Query: 320 KEYLNRQNMELSVRCA---HEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENK 376
+ Y ELS + +ED++++LQ ++ K +M Y + +
Sbjct: 567 EVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQT 626
Query: 377 LHDELEQIRLKTNQEIDQLRNASREMYER-----------EN-----RNLREARDNAVAE 420
L D E + L +E LR+ + E+ E+ EN ++ EA+ +
Sbjct: 627 LFDA-ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD 685
Query: 421 KERAVMAEKDALEKHDQLLDRY--REL--QLSTESKVTEFLHQSKLKSFESERVQLLQEE 476
E+ + + + + K L+D ++L L E K+T+ Q +L E E + L+EE
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL--QKELNK-EVEENEALREE 742
Query: 477 TA--RNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLE 534
L E E+ +K+++ ++E + + + +K +E+ + S Q L E++
Sbjct: 743 VILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLL---EEIG 799
Query: 535 KELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLI 594
K D++ + ++ D+ + + + K L+++ + + ++ L K+
Sbjct: 800 KTKDDLATTQSNYKSTDQEFQNFKTLHM--DFEQKYKMVLEENERMNQEIVNLSKEAQKF 857
Query: 595 LKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDS-------LTESI 647
L K +++ +QEL + + L E + RDS + + +TE +
Sbjct: 858 DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKL 917
Query: 648 AQLEKDVSNLNKEKSALLQTKNQMALDLEQL 678
Q ++V L +EK L Q + + ++ +QL
Sbjct: 918 QQTLEEVKTLTQEKDDLKQLQESLQIERDQL 948
Score = 76.6 bits (187), Expect = 8e-14
Identities = 157/734 (21%), Positives = 312/734 (42%), Gaps = 102/734 (13%)
Query: 7 KESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLLKIE 66
K +K + + E++SLET + + E++ QL+E K+LL +Q KIE
Sbjct: 346 KRYRKEIMDLKKQLEEVSLETR------AQAMEKDQLA----QLLEEKDLLQKVQNEKIE 395
Query: 67 -------LSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASK 119
S + LK ++ K+N + + + + S
Sbjct: 396 NLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLS- 454
Query: 120 YQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSI 179
L+++ E++ T L E + L + E E + L+A D L +
Sbjct: 455 -INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRA-DYDNL-V 511
Query: 180 PEYVSVRFYELVNPLRKEICELQVK-KNILAE----ELSTNKNQLKQLTETYEEDRKNYS 234
+Y +R KE EL++K KN L E E T K+Q QL +
Sbjct: 512 LDYEQLR-------TEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVK 564
Query: 235 EVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMI 294
++ Q L EL+ +L+ +E D++K ++ ++ + +E + ++ S+ +
Sbjct: 565 HAEVYNQDLENELSSKVELL------REKEDQIKKLQEYIDSQKLENIK----MDLSYSL 614
Query: 295 QTKERSELSKEVVTLEQTVTL-LQKDKEYLNRQNMELSVRC-------AHEEDRLERLQA 346
++ E + K+ + +TV L +++ +L +N+EL + E+ ++ Q+
Sbjct: 615 ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS 674
Query: 347 QLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYE-- 404
QLE KK + ++ EK + S + T+ + + ++ + L + ++ + +E+ +
Sbjct: 675 QLEAKKKMQVDL-EKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEV 733
Query: 405 RENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQLSTESK---VTEFLHQSK 461
EN LRE + + + +++ +E + L K ++ D+ EL + T K +E +H
Sbjct: 734 EENEALRE--EVILLSELKSLPSEVERLRK--EIQDKSEELHIITSEKDKLFSEVVH--- 786
Query: 462 LKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNS 521
+ RVQ L EE + TK+ + S+ K T+ + QN
Sbjct: 787 ----KESRVQGLLEEIGK-------------------TKDDLATTQSNYKS-TDQEFQNF 822
Query: 522 EHQARLDIYEKLEKELDEIIMQTAEIEN-EDEAERVLFSYGYGANVPTTAKRRLKQSVHL 580
+ +D +K + L+E EI N EA++ F GA + T + ++
Sbjct: 823 K-TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQK--FDSSLGA-LKTELSYKTQELQEK 878
Query: 581 ARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKI 640
R V + + + + LE+R + Q ++R +L+ + Q ++++ Q +
Sbjct: 879 TREVQERLNEMEQLKEQLENRDSTL----QTVEREKTLITEKLQQTLEEVKTLTQEKDDL 934
Query: 641 DSLTESIAQLEKD--VSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSK 698
L ES+ Q+E+D S+++ + + T+ Q+ LE L H+E + +K + + S+
Sbjct: 935 KQLQESL-QIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSR 993
Query: 699 --HSENSLLLTKTE 710
H E + TK E
Sbjct: 994 NLHMEENTGETKDE 1007
Score = 70.5 bits (171), Expect = 6e-12
Identities = 131/624 (20%), Positives = 256/624 (41%), Gaps = 76/624 (12%)
Query: 155 NLRDFELTEEQYIKLKAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELST 214
N RD +LT L + ++ I V F E + L+ +K E+ST
Sbjct: 282 NYRDSKLTRILQNSLGGNAKTRI-ICTITPVSFDETLTALQFASTAKYMKNTPYVNEVST 340
Query: 215 NKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQ-------ENYDK- 266
++ LK+ + + +K EV + + A+E QL+++ D Q EN +
Sbjct: 341 DEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRM 400
Query: 267 -VKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKE--------VVTLEQTVTLLQ 317
V S L+QE ++ +RK + I + S + + T + ++ LL+
Sbjct: 401 LVTSSSLTLQQE-LKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLR 459
Query: 318 KDKEYLNRQN----------MELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRD 367
+ E + ++ E+ A + E ++++L + + + Y R
Sbjct: 460 EIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRT 519
Query: 368 HYKTEYENKLH-----DELEQIRLKTNQ--------EIDQLRNASR--EMYERENRNLRE 412
K E E KL DE E + KT + EI L+N + E+Y ++ N
Sbjct: 520 E-KEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELS 578
Query: 413 ARDNAVAEKERAVMAEKDALEKHDQLLDRYR----ELQLSTESKVTEFLHQSKLKSFESE 468
++ + EKE D ++K + +D + ++ LS + E Q K F++E
Sbjct: 579 SKVELLREKE-------DQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAE 631
Query: 469 RVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQ-NSEHQARL 527
V L + + L LE ++ K+L K+ E I Q+Q ++ + ++
Sbjct: 632 TVALDAKRESAFLRSENLELKEKMKELATTYKQM-------ENDIQLYQSQLEAKKKMQV 684
Query: 528 DIYEKLEKELDEIIMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQL 587
D+ ++L+ +EI T+ I+ + + +L + + T ++ L + V +
Sbjct: 685 DLEKELQSAFNEITKLTSLIDGKVPKD-LLCNLELEGKI-TDLQKELNKEVEENEAL--- 739
Query: 588 EKQNSLILKDLEHRKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESI 647
++ ++L +L+ +V +L +E+ + L+ L V ++S++ L E I
Sbjct: 740 -REEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEI 798
Query: 648 AQLEKDVSNLN---KEKSALLQTKNQMALDLEQLLNH-REELAAMKQILVKM--HSKHSE 701
+ + D++ K Q + +D EQ EE M Q +V + ++ +
Sbjct: 799 GKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD 858
Query: 702 NSLLLTKTEPKHVTENQKSKTLNV 725
+SL KTE + T+ + KT V
Sbjct: 859 SSLGALKTELSYKTQELQEKTREV 882
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 95.5 bits (236), Expect = 2e-19
Identities = 156/752 (20%), Positives = 315/752 (41%), Gaps = 97/752 (12%)
Query: 2 SRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELL---- 57
SR K S + +L+ + +E + D+ +E + + IE++ L
Sbjct: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGE--IEQELALARDG 398
Query: 58 HNIQLLKIELSQ---KTMM--IDNLKVDYLTKIEELEEKLNDA---LHQKQLLTLRLDNQ 109
H+ +L++E +TM+ D KV+ L ++EE + K+ D + ++ + L+ Q
Sbjct: 399 HDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQ 458
Query: 110 LAFQQKDASKYQELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKL 169
+ + ++ + E Q++LE+T + V R EL ++ +++
Sbjct: 459 TKLEHARIKELEQSLLFEKTKADKLQRELEDT------RVATVSEKSRIMELEKDLALRV 512
Query: 170 KAFPEDQLSIPEYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEED 229
+ E + + ++ L +EI LQ K + + LK+ EE
Sbjct: 513 QEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREET 572
Query: 230 -RKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEIL 288
+K + ++L+ E K ++ + +EN D + + LE + ++ E L
Sbjct: 573 HQKEIKALYTATEKLSKENESLKSKLEHAN--KENSDVIALWKSKLETAIASHQQAMEEL 630
Query: 289 EASHM----IQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERL 344
+ S +T E +EL ++ + L E N QN + S R AH ++ +E L
Sbjct: 631 KVSFSKGLGTETAEFAELKTQIEKMR-----LDYQHEIENLQNQQDSERAAHAKE-MEAL 684
Query: 345 QAQL----EESKKAREEMYEKYVASRDHYKTEYE---NKLHD------ELEQIRLKTNQE 391
+A+L +E + + E + K + D + E E NKL + ELE ++ K N++
Sbjct: 685 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQ 744
Query: 392 IDQLRNASREMYERENR-----NLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQ 446
+ N + ++ E + LR+A +E ++ + + +A EK + L+ + +
Sbjct: 745 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKK-LRQQLEAAEKQIKHLEIEKNAE 803
Query: 447 LSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEF---- 502
S S +T L +LK + LQE NL++ E +K+L++L ++F
Sbjct: 804 SSKASSITRELQGRELK------LTNLQE----NLSEVSQVKETLEKELQILKEKFAEAS 853
Query: 503 ---YSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENEDEAERVLFS 559
S+Q S ++ + +L + + EKL + L ++ A+ +DE E L
Sbjct: 854 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADM---EAKFREKDEREEQLIK 910
Query: 560 YGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQELDRANSLL 619
AK +L+ + ++++ NS Q+T+++ EL +
Sbjct: 911 ----------AKEKLENDI---AEIMKMSGDNS----------SQLTKMNDELRLKERDV 947
Query: 620 NQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTK-NQMALDLEQL 678
+ Q E+ I+ +T Q +++ + ++E+ L+ K + + +E
Sbjct: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETS 1007
Query: 679 LNHREEL-AAMKQILVKMHSKHSENSLLLTKT 709
N +EL A ++ + +KH E L KT
Sbjct: 1008 HNQCQELKARYERATSETKTKHEEILQNLQKT 1039
Score = 80.9 bits (198), Expect = 4e-15
Identities = 130/674 (19%), Positives = 272/674 (40%), Gaps = 102/674 (15%)
Query: 121 QELMKQEMETI--LLRQKQLEETNL-QLREKAGDVRRNLRDFELTEEQYI-KLKAFPEDQ 176
QE +K++ + I LL ++ LE + + G++ + L +Q++ +L+A +
Sbjct: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
Query: 177 LSIPEYVSVRFYELVNPLRKE---ICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNY 233
++ E EL+N L +E + +LQ + EE S K L+ T+ K
Sbjct: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFR----VEEESITKGDLETQTKLEHARIKEL 469
Query: 234 SEVQI----RCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHE--- 286
+ + + +L EL DT+ R +K + R QEV ELRR+ E
Sbjct: 470 EQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALR---VQEVAELRRRLESNK 526
Query: 287 ----------ILEASHMIQTK---ERSELSKEVVTLEQ-----------TVTLLQKDKEY 322
+L+ +Q K R++ +E+ +L++ + L E
Sbjct: 527 PAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEK 586
Query: 323 LNRQNMELSVRCAHEEDR--------LERLQAQLEESKKAREEMYEKYVASRDHYKTEYE 374
L+++N L + H +L+ + ++A EE+ + E+
Sbjct: 587 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 646
Query: 375 NKLHDELEQIRLKTNQEIDQLRN---ASREMYERENRNLREARDNAVAEKERAVMAEKDA 431
+L ++E++RL EI+ L+N + R + +E LR + EKE ++ A +
Sbjct: 647 -ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSK 705
Query: 432 LEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKY 491
L+K + D++ T +K+ E E + L Q +C +
Sbjct: 706 LDKAE---DQHLVEMEDTLNKLQE------------------AEIKVKELEVLQAKCNEQ 744
Query: 492 QKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEIIMQTAEIENED 551
K ++ T + ++E+++ +L A +KL ++L+ Q +E E
Sbjct: 745 TKVIDNFTSQL----KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK 800
Query: 552 EAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEHRKDQVTQLSQE 611
AE +++ + R + +L + ++ + + K+L+ K++ + S+E
Sbjct: 801 NAES-----SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEE 855
Query: 612 LDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKEKSALLQTKNQM 671
+ +T E S ++ L E++A +E ++ + L++ K ++
Sbjct: 856 AVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKL 915
Query: 672 ALDL-----------EQLLNHREELAAMKQILVKMH---SKHSENSLLLTKTEPKHVTEN 717
D+ QL +EL ++ + ++ +K +EN+ L K+ +
Sbjct: 916 ENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKA 975
Query: 718 QKSKTLNVPKEHED 731
++S+ K+HE+
Sbjct: 976 EQSQQ-EAAKKHEE 988
Score = 79.3 bits (194), Expect = 1e-14
Identities = 128/556 (23%), Positives = 239/556 (42%), Gaps = 87/556 (15%)
Query: 4 KISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNIQLL 63
K ++ SK +I+ L+ ++ L ++ +E +V ++ +E++ +Q+L
Sbjct: 800 KNAESSKASSITRELQGRELKL---------TNLQENLSEVSQVKETLEKE-----LQIL 845
Query: 64 K---IELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRL-DNQLAFQQKDASK 119
K E S++ + + + + K+ + EE+ N + L L D + F++KD +
Sbjct: 846 KEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDERE 905
Query: 120 YQELM-KQEMETILLR-QKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPED-- 175
Q + K+++E + K + + QL + ++R RD EE +KL E+
Sbjct: 906 EQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERD---VEELQLKLTKANENAS 962
Query: 176 --QLSIPEYVSVRF----YELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYE-- 227
Q SI E ++V+ E +E EL+ K + L +++ T+ NQ ++L YE
Sbjct: 963 FLQKSI-EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERA 1021
Query: 228 --EDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKH 285
E + + E+ Q L L DT+ ++ + E L QE+ ELR++
Sbjct: 1022 TSETKTKHEEI---LQNLQKTLLDTEDKLKGA----------REENSGLLQELEELRKQA 1068
Query: 286 EILEASHMIQ---------TKERSELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAH 336
+ +A+ + TKE++E + +QT LQ + + L N++
Sbjct: 1069 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1128
Query: 337 EEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYEN--KLHDELEQIR------LKT 388
++ L ++EE +K E + + E KL +EL + R K
Sbjct: 1129 SKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL 1188
Query: 389 NQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRE--LQ 446
+E L N EM +RE++ +++A D A ++++ L + D L++ R
Sbjct: 1189 EEERSVLNNQLLEMKKRESKFIKDA-DEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1247
Query: 447 LSTESKVTEFLHQSKLKSFESERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSLQ 506
L E+ + LH S +++ ES++V+L E K LE+ KE Q
Sbjct: 1248 LRGENASAKSLH-SVVQTLESDKVKL----------------ELKVKNLELQLKE-NKRQ 1289
Query: 507 ASSEKRITELQAQNSE 522
SS T+ QA E
Sbjct: 1290 LSSSSGNTDTQADEDE 1305
Score = 72.4 bits (176), Expect = 1e-12
Identities = 111/538 (20%), Positives = 218/538 (40%), Gaps = 96/538 (17%)
Query: 208 LAEELSTNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADTKQLIQQGDYRQENYDKV 267
+A +S+ ++ LTET + S + L + +QL+ + D + K
Sbjct: 322 VASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKA 381
Query: 268 KSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVTLLQKDKEYLNRQN 327
S +EQE+ R H+ + V+ LE + L+ E +R+
Sbjct: 382 TSHVGEIEQELALARDGHD-----------------QHVLELEAKMDQLRTMVEAADREK 424
Query: 328 MELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYENKLHDELEQIRLK 387
+EL + E+ ++E LQ ++EE + ++ +T+ E+ ELEQ L
Sbjct: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDL---------ETQTKLEHARIKELEQSLLF 475
Query: 388 TNQEIDQLRNASREMYERENRNLREARDNAVAEKERAVMAEKDALEKHDQLLDRYRELQL 447
+ D+L+ R L + R V+EK R + EKD + ++ + R L+
Sbjct: 476 EKTKADKLQ-----------RELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLES 524
Query: 448 STESKVTEFLHQSKLKSFES--ERVQLLQEETARNLTQCQLECEKYQKKLEVLTKEFYSL 505
+ + + + S L+ S E++++ + + R +T + E + + E KE +L
Sbjct: 525 NKPAGDVD-MSLSLLQEISSLQEKLEVTRTDHQREITSLK---EHFGAREETHQKEIKAL 580
Query: 506 QASSEKRITELQAQNSEHQARLDIYEKLEKELDEII------MQTAEIENEDEAERVLFS 559
++EK L +N +++L E KE ++I ++TA ++ E + S
Sbjct: 581 YTATEK----LSKENESLKSKL---EHANKENSDVIALWKSKLETAIASHQQAMEELKVS 633
Query: 560 YGYGANVPTTAKRRLKQSVHLARRVLQLEKQN--------------------SLILKDLE 599
+ G T LK + R Q E +N + ++K ++
Sbjct: 634 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 693
Query: 600 HRKDQVTQLSQELDRA--------NSLLNQTQQ------PYRYLIESVRQRDSKIDSLTE 645
+++ + + +LD+A LN+ Q+ L ++ ID+ T
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 753
Query: 646 SIAQLEKDVSNLNKEKSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENS 703
+ E+ + +L+ + A + K++M +QL AA KQI K++E+S
Sbjct: 754 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQL------EAAEKQIKHLEIEKNAESS 805
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,043,451
Number of Sequences: 37866
Number of extensions: 1065917
Number of successful extensions: 14446
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 257
Number of HSP's successfully gapped in prelim test: 1160
Number of HSP's that attempted gapping in prelim test: 6203
Number of HSP's gapped (non-prelim): 4614
length of query: 757
length of database: 18,247,518
effective HSP length: 110
effective length of query: 647
effective length of database: 14,082,258
effective search space: 9111220926
effective search space used: 9111220926
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.