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Search of human proteins with 5454086
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5454086 sushi-repeat-containing protein, X-linked [Homo
sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5454086 sushi-repeat-containing protein, X-linked [Homo sapiens] 964 0.0
gi|7657619 sushi-repeat-containing protein, X-linked 2 [Homo sap... 439 e-123
gi|187960042 selectin E precursor [Homo sapiens] 99 8e-21
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 91 2e-18
gi|148886654 polydom [Homo sapiens] 91 2e-18
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 86 9e-17
gi|157419154 selectin P precursor [Homo sapiens] 84 2e-16
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 76 6e-14
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 76 6e-14
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 76 6e-14
gi|27502421 CD46 antigen, complement regulatory protein isoform ... 70 3e-12
gi|27502417 CD46 antigen, complement regulatory protein isoform ... 70 3e-12
gi|27502415 CD46 antigen, complement regulatory protein isoform ... 70 3e-12
gi|27502407 CD46 antigen, complement regulatory protein isoform ... 70 3e-12
gi|24432108 CD46 antigen, complement regulatory protein isoform ... 70 3e-12
gi|41152076 steroid-sensitive protein 1 [Homo sapiens] 70 5e-12
gi|41152074 steroid-sensitive protein 1 [Homo sapiens] 70 5e-12
gi|27502419 CD46 antigen, complement regulatory protein isoform ... 69 9e-12
gi|27502413 CD46 antigen, complement regulatory protein isoform ... 69 9e-12
gi|27502411 CD46 antigen, complement regulatory protein isoform ... 69 9e-12
gi|27502409 CD46 antigen, complement regulatory protein isoform ... 69 9e-12
gi|27502405 CD46 antigen, complement regulatory protein isoform ... 69 9e-12
gi|27502402 CD46 antigen, complement regulatory protein isoform ... 69 9e-12
gi|27502427 CD46 antigen, complement regulatory protein isoform ... 69 9e-12
gi|27502425 CD46 antigen, complement regulatory protein isoform ... 69 9e-12
gi|27502423 CD46 antigen, complement regulatory protein isoform ... 69 9e-12
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ... 59 7e-09
gi|67782358 complement factor B preproprotein [Homo sapiens] 59 1e-08
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi... 59 1e-08
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi... 59 1e-08
>gi|5454086 sushi-repeat-containing protein, X-linked [Homo sapiens]
Length = 464
Score = 964 bits (2493), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSHPRYKDTPWCSPI 60
MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSHPRYKDTPWCSPI
Sbjct: 1 MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSHPRYKDTPWCSPI 60
Query: 61 KVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVICKQKRC 120
KVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVICKQKRC
Sbjct: 61 KVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVICKQKRC 120
Query: 121 PTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPP 180
PTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPP
Sbjct: 121 PTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPP 180
Query: 181 RIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYT 240
RIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYT
Sbjct: 181 RIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYT 240
Query: 241 VYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSP 300
VYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSP
Sbjct: 241 VYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSP 300
Query: 301 ARVCQSNLAWSGTEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLG 360
ARVCQSNLAWSGTEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLG
Sbjct: 301 ARVCQSNLAWSGTEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLG 360
Query: 361 MLQQAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYSFSMVLVD 420
MLQQAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYSFSMVLVD
Sbjct: 361 MLQQAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYSFSMVLVD 420
Query: 421 KHGMDKERYVSLVMPVALFNLIDTFPLRKEEMVLQAEMSQTCNT 464
KHGMDKERYVSLVMPVALFNLIDTFPLRKEEMVLQAEMSQTCNT
Sbjct: 421 KHGMDKERYVSLVMPVALFNLIDTFPLRKEEMVLQAEMSQTCNT 464
>gi|7657619 sushi-repeat-containing protein, X-linked 2 [Homo
sapiens]
Length = 465
Score = 439 bits (1129), Expect = e-123
Identities = 207/453 (45%), Positives = 294/453 (64%), Gaps = 8/453 (1%)
Query: 17 LLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSHP-------RYKDTPWCSPIKVKYGDVYC 69
LL L V P+ + GSG P E Y+ Y+ WC + ++ G+ C
Sbjct: 13 LLFFLTPAVTPTW-YAGSGYYPDESYNEVYAEEVPQAPALDYRVPRWCYTLNIQDGEATC 71
Query: 70 RAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVICKQKRCPTLAMPANG 129
+P+GG Y ++LGTRC++ C +G+ L G + C ++RWS C+Q RC L +G
Sbjct: 72 YSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTAYCRQMRCHALPFITSG 131
Query: 130 GFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKE 189
+ C +G +SRC+Y CS GY L+G+R+ CM++ WSG CVD++PP+I+CP +E
Sbjct: 132 TYTCTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSRE 191
Query: 190 RIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKG 249
++AEP KLT RV W+ P +D+ADG +T V L+G PGS+FPEG+H I+YT YDRA N+
Sbjct: 192 KMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRA 251
Query: 250 TCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA 309
+CKF VKV+V+RC L P++GY+ C+S GDNYGATCE+ C GGY+ QG+P+RVCQS+
Sbjct: 252 SCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQ 311
Query: 310 WSGTEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGL 369
WSG+ P CA M +NV V +AA LLDQFYEK+RLLI+S P N Y++Q+ MLQQ+ CGL
Sbjct: 312 WSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGL 371
Query: 370 DLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERY 429
DLRH+T++ELVG P +GRI + + + +LR R+ F+MVL+DK G+D++RY
Sbjct: 372 DLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSYFNMVLIDKQGIDRDRY 431
Query: 430 VSLVMPVALFNLIDTFPLRKEEMVLQAEMSQTC 462
+ V P +F ID + L +E+ + E C
Sbjct: 432 MEPVTPEEIFTFIDDYLLSNQELTQRREQRDIC 464
>gi|187960042 selectin E precursor [Homo sapiens]
Length = 610
Score = 99.0 bits (245), Expect = 8e-21
Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 32/266 (12%)
Query: 63 KYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCP 121
++G + C P G + + + C I C +GY + C S+ WS + C C
Sbjct: 187 EHGSLVCSHPLGNF---SYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACNVVECD 243
Query: 122 TLAMPANGGFKCVD--GAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDME 178
+ PANG +C G++ +N+ C + C G+ L G +++ C + W +C
Sbjct: 244 AVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTC---- 299
Query: 179 PPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQ 238
+ C +V++ P +VR S +P G T +G +G +++
Sbjct: 300 -KAVTCRAVRQ----PQNGSVRCS-HSPAGEFTFKSSCNFTCEEGF-----MLQGPAQVE 348
Query: 239 YTVYDRAENKGTCKFRVKV-RVKRCGKLNAPENGYMKC---SSDGDNYGATCEFSCIGGY 294
T +G ++ V +C L+ PE GYM C +S YG++CEFSC G+
Sbjct: 349 CTT------QGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGF 402
Query: 295 ELQGSPARVCQSNLAWSGTEPTCAAM 320
L+GS C W +PTC A+
Sbjct: 403 VLKGSKRLQCGPTGEWDNEKPTCEAV 428
Score = 97.4 bits (241), Expect = 2e-20
Identities = 71/261 (27%), Positives = 113/261 (43%), Gaps = 30/261 (11%)
Query: 65 GDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTL 123
G V C G + + C+ C++G+ L G + + C + +W+ ++ +C+ +C L
Sbjct: 313 GSVRCSHSPAGEF--TFKSSCNFTCEEGFMLQGPAQVECTTQGQWTQQIPVCEAFQCTAL 370
Query: 124 AMPANGGFKCVDGAY----FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEP 179
+ P G C+ A + S CE+ C G+ LKG + + C W +C
Sbjct: 371 SNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTC----- 425
Query: 180 PRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLP-PGSNFPEGDHKIQ 238
++C +V + P K VR + +P G T +G GS E + Q
Sbjct: 426 EAVRCDAVHQ----PPKGLVRCA-HSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQ 480
Query: 239 YTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQG 298
+T E +C+ V +C L P M CS + +G C+F+C G+ L G
Sbjct: 481 WT-----EEVPSCQ------VVKCSSLAVPGKINMSCSGE-PVFGTVCKFACPEGWTLNG 528
Query: 299 SPARVCQSNLAWSGTEPTCAA 319
S AR C + WSG PTC A
Sbjct: 529 SAARTCGATGHWSGLLPTCEA 549
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/81 (27%), Positives = 34/81 (41%), Gaps = 2/81 (2%)
Query: 258 RVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQGSPARVCQSNLAWSGTEP 315
++ C L +PE+G + CS N Y ++C SC GY C S+ WS P
Sbjct: 176 QIVNCTALESPEHGSLVCSHPLGNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIP 235
Query: 316 TCAAMNVNVGVRTAAALLDQF 336
C + + A ++ F
Sbjct: 236 ACNVVECDAVTNPANGFVECF 256
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 90.9 bits (224), Expect = 2e-18
Identities = 84/280 (30%), Positives = 114/280 (40%), Gaps = 47/280 (16%)
Query: 61 KVKYGDVYCRAPQG-------GYYKTALGTRCDIRCQKGYELHGSSLLIC----QSNKRW 109
K++Y YC P+ G T G C GY L G S+ IC Q W
Sbjct: 2460 KIRYSAPYCSLPRAPLHGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAICTRHPQGYHLW 2519
Query: 110 SDKV-ICKQKRCPTLAMPANGGFKCVDGAYFN--SRCEYYCSPGYTLKG--ERTVTCMDN 164
S+ + +C+ C P NG V G + ++ Y CS GY L+ E T C+D
Sbjct: 2520 SEAIPLCQALSCGLPEAPKNG---MVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDT 2576
Query: 165 KAWSGR--PASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILK 222
WS R P CV + CP V E + R+ +ET ++ D
Sbjct: 2577 GLWSNRNVPPQCVP-----VTCPDVSSISVEHGRW--RLIFETQYQFQAQLMLICD---- 2625
Query: 223 GLPPGSNFPEGDHKIQYTV---YDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDG 279
PG + G I+ + ++ TC R+ CG+L P NG+ +
Sbjct: 2626 ---PGYYYT-GQRVIRCQANGKWSLGDSTPTC------RIISCGELPIPPNGHRIGTLSV 2675
Query: 280 DNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAA 319
YGAT FSC GY L GS R C +N WSG+E C A
Sbjct: 2676 --YGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLA 2713
Score = 72.8 bits (177), Expect = 6e-13
Identities = 67/236 (28%), Positives = 90/236 (38%), Gaps = 33/236 (13%)
Query: 88 RCQKGY--ELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDGAY-FNSRC 143
+C GY E H S+L C ++ W+ K +CK C + NG K V + + S
Sbjct: 2977 QCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNG--KVVGSDFMWGSSV 3034
Query: 144 EYYCSPGYTLKGERTVTCMDNKAWSGRPASC--VDMEPPRIKCPSVKERIAEPNKLTVRV 201
Y C GY L TC N +W+G C V P + +E + +V
Sbjct: 3035 TYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFSYRSSVSF 3094
Query: 202 SWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKR 261
S P ++L G P F + D GT + +
Sbjct: 3095 SCHPP------------LVLVGSP--RRFCQSD----------GTWSGTQPSCIDPTLTT 3130
Query: 262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
C P+ G +S G G+T F C GY LQGS R C NL WSGT P C
Sbjct: 3131 CADPGVPQFGIQN-NSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDC 3185
Score = 71.6 bits (174), Expect = 1e-12
Identities = 68/272 (25%), Positives = 99/272 (36%), Gaps = 38/272 (13%)
Query: 82 GTRCDIRCQKGYELHGSSLLICQSNKRWS-DKVICKQKRCPTLAMPANGGFKCVDGAYFN 140
GT C+ G+ L GSS CQ+N WS + C C P+N DG F+
Sbjct: 2854 GTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPSNARVVFSDGLVFS 2913
Query: 141 SRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVR 200
S Y C GY G + C N W+G C+ + P+ R+ +
Sbjct: 2914 SSIVYECREGYYATGLLSRHCSVNGTWTGSDPECLVINCGDPGIPANGLRLGNDFRYNKT 2973
Query: 201 VSWETPEG------RDTADGILTDVILKGLPP-------------------GSNFPEGD- 234
V+++ G R + D G P GS+F G
Sbjct: 2974 VTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALMCKPPPLIPNGKVVGSDFMWGSS 3033
Query: 235 --------HKIQYTVYDRAENKGTCKFRV-KVRVKRCGKLNAPENGYMKCSSDGDNYGAT 285
+++ E G+ + + CG P G + G +Y ++
Sbjct: 3034 VTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRG--RREDRGFSYRSS 3091
Query: 286 CEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
FSC L GSP R CQS+ WSGT+P+C
Sbjct: 3092 VSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSC 3123
Score = 67.0 bits (162), Expect = 3e-11
Identities = 60/241 (24%), Positives = 88/241 (36%), Gaps = 26/241 (10%)
Query: 82 GTRCDIRCQKGYELHGSSLLICQSNKRWS-DKVICKQKRCPTLAMPANGGFKCVDGAYFN 140
G C GY L GS + C +N WS +V C C T NG + +Y
Sbjct: 2677 GATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENYSYRG 2736
Query: 141 SRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVR 200
S Y C+ G+ L G C + WSG+ CV + C P
Sbjct: 2737 S-VVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCV-----LVSC-------GHPG----- 2778
Query: 201 VSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVK 260
P + + D +++ G G+ + G+ V
Sbjct: 2779 ---SPPHSQMSGDSYTVGAVVRYSCIGKRTLVGNSTRMCGL--DGHWTGSLPHCSGTSVG 2833
Query: 261 RCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAM 320
CG P +G D + G FSC G+ L+GS R CQ+N +WSG++P C +
Sbjct: 2834 VCGDPGIPAHGIR--LGDSFDPGTVMRFSCEAGHVLRGSSERTCQANGSWSGSQPECGVI 2891
Query: 321 N 321
+
Sbjct: 2892 S 2892
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/101 (30%), Positives = 45/101 (44%), Gaps = 2/101 (1%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGAYF 139
+G+ RCQKGY L GS+ C N WS C C P + +D
Sbjct: 3150 VGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCVPHHCRQPETPTHANVGALDLPSM 3209
Query: 140 NSRCEYYCSPGYTLKG-ERTVTCMDNKAWSGRPASCVDMEP 179
Y C G++LKG TC + +W+G+P C+++ P
Sbjct: 3210 GYTLIYSCQEGFSLKGGSEHRTCKADGSWTGKPPICLEVRP 3250
Score = 54.3 bits (129), Expect = 2e-07
Identities = 66/302 (21%), Positives = 113/302 (37%), Gaps = 51/302 (16%)
Query: 71 APQGGYY---KTALGTRCDIRCQKGYELHGSSLLI--CQSNKRWSDKVI---CKQKRCPT 122
AP+ G + +GT+ C +GY L + C WS++ + C CP
Sbjct: 2536 APKNGMVFGKEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPVTCPD 2595
Query: 123 LAMPA--NGGFKCV-DGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWS--GRPASCVD 176
++ + +G ++ + + Y F ++ C PGY G+R + C N WS +C
Sbjct: 2596 VSSISVEHGRWRLIFETQYQFQAQLMLICDPGYYYTGQRVIRCQANGKWSLGDSTPTCRI 2655
Query: 177 MEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNF------ 230
+ + P RI + + G + + + GL GS
Sbjct: 2656 ISCGELPIPPNGHRIGTLSVYGATAIFSCNSGYTLVGSRVRECMANGLWSGSEVRCLAGH 2715
Query: 231 ---PEG---------DHKIQYTVYDRAENKGTCKFRVKVRVKR----------------C 262
PE ++ + +V + N G + VR+ + C
Sbjct: 2716 CGTPEPIVNGHINGENYSYRGSVVYQC-NAGFRLIGMSVRICQQDHHWSGKTPFCVLVSC 2774
Query: 263 GKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAMNV 322
G +P + M S D GA +SCIG L G+ R+C + W+G+ P C+ +V
Sbjct: 2775 GHPGSPPHSQM--SGDSYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSV 2832
Query: 323 NV 324
V
Sbjct: 2833 GV 2834
Score = 51.2 bits (121), Expect = 2e-06
Identities = 55/251 (21%), Positives = 86/251 (34%), Gaps = 51/251 (20%)
Query: 82 GTRCDIRCQKGYELHGSSLLICQSNKRWSDK------VICKQKRCPTLAMPANGGFKCVD 135
G+ C +GY+L ++ C+ N W+ + V C P+ + GF
Sbjct: 3031 GSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQCFPVFCGDPGVPSRGRREDRGFS--- 3087
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
+ S + C P L G C + WSG SC+D P V + + N
Sbjct: 3088 ---YRSSVSFSCHPPLVLVGSPRRFCQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNN 3144
Query: 196 KLTVRVS----WETPEG----RDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAEN 247
+V + +G T L ++ G PP P
Sbjct: 3145 SQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDC-VPH--------------- 3188
Query: 248 KGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQ-GSPARVCQS 306
C+ G L+ P GY T +SC G+ L+ GS R C++
Sbjct: 3189 --HCRQPETPTHANVGALDLPSMGY------------TLIYSCQEGFSLKGGSEHRTCKA 3234
Query: 307 NLAWSGTEPTC 317
+ +W+G P C
Sbjct: 3235 DGSWTGKPPIC 3245
Score = 48.1 bits (113), Expect = 2e-05
Identities = 36/114 (31%), Positives = 46/114 (40%), Gaps = 16/114 (14%)
Query: 70 RAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVICKQKRC--PTLAMPA 127
R +G Y++++ C L GS CQS+ WS Q C PTL A
Sbjct: 3081 REDRGFSYRSSVS----FSCHPPLVLVGSPRRFCQSDGTWSGT----QPSCIDPTLTTCA 3132
Query: 128 NGGFKCV------DGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
+ G G S + C GY L+G T TC+ N WSG P CV
Sbjct: 3133 DPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTTRTCLPNLTWSGTPPDCV 3186
Score = 47.8 bits (112), Expect = 2e-05
Identities = 66/270 (24%), Positives = 100/270 (37%), Gaps = 64/270 (23%)
Query: 91 KGYELHGSSLLICQSNKRWSDKVICKQKRCPTLAMPANGGFKCVDGAYF-NSRCEYYCSP 149
KG+ELH SS + + C+ P G+K D +F S + C P
Sbjct: 1197 KGFELHFSSF----------ELIKCEDPGTPKF------GYKVHDEGHFAGSSVSFSCDP 1240
Query: 150 GYTLKGERTVTCM--DNKAWSGRP-----ASCVDMEPPRIKCPSVKERIAEPNKLTVRVS 202
GY+L+G + C+ + + W RP A C + + P + +
Sbjct: 1241 GYSLRGSEELLCLSGERRTWD-RPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCI 1299
Query: 203 W-----------------ETPEGRDTA---DG-ILTDVILKGLPPGSNFPEGDHK----- 236
W +T E D DG + + V+LK L G P+ H
Sbjct: 1300 WTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGPVESGVLLKEL-SGPALPKDLHSTFNSV 1358
Query: 237 -IQYTVYDRAENKG-TCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNY--GATCEFSCIG 292
+Q++ +G +F V C P+NG S GD++ G + F C
Sbjct: 1359 VLQFSTDFFTSKQGFAIQFSVSTATS-CNDPGIPQNG----SRSGDSWEAGDSTVFQCDP 1413
Query: 293 GYELQGSPARVC---QSNLAWSGTEPTCAA 319
GY LQGS C ++ W + PTC A
Sbjct: 1414 GYALQGSAEISCVKIENRFFWQPSPPTCIA 1443
Score = 47.0 bits (110), Expect = 4e-05
Identities = 55/234 (23%), Positives = 86/234 (36%), Gaps = 37/234 (15%)
Query: 95 LHGSSLLICQSNKRWSDKVI-CKQKR---CPTLAMPANGGFKCVDGAYFNSRCEYYCSPG 150
L G+S +C + W+ + C C +PA+G + D + + C G
Sbjct: 2806 LVGNSTRMCGLDGHWTGSLPHCSGTSVGVCGDPGIPAHG-IRLGDSFDPGTVMRFSCEAG 2864
Query: 151 YTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVS--WETPEG 208
+ L+G TC N +WSG C + PS R+ + L S +E EG
Sbjct: 2865 HVLRGSSERTCQANGSWSGSQPECGVISCGNPGTPS-NARVVFSDGLVFSSSIVYECREG 2923
Query: 209 RDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAP 268
+ + G GS+ PE V CG P
Sbjct: 2924 YYATGLLSRHCSVNGTWTGSD-PE------------------------CLVINCGDPGIP 2958
Query: 269 ENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARV--CQSNLAWSGTEPTCAAM 320
NG ++ +D Y T + C+ GY ++ V C + W+GT+P C A+
Sbjct: 2959 ANG-LRLGNDF-RYNKTVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKAL 3010
Score = 45.1 bits (105), Expect = 1e-04
Identities = 51/245 (20%), Positives = 89/245 (36%), Gaps = 39/245 (15%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQSNK----RWSD-KVICKQKRCPTLAMPANGGFKCVD 135
LG+ C +GY+L GS + C WSD + +C+ + C
Sbjct: 361 LGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVCRARMCD-------------- 406
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
A+ SP + ++ + C+ W + P ++ + +E E
Sbjct: 407 -AHLRGPSGIITSPNFPIQYDNNAHCV----WI-----ITALNPSKVIKLAFEEFDLERG 456
Query: 196 KLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRV 255
T+ V +G D IL G +H++ + ++ + + F+
Sbjct: 457 YDTLTVG----DGGQDGDQKTVLYILTGTSVPDLIVSTNHQM-WLLFQTDGSGSSLGFKA 511
Query: 256 ---KVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSG 312
++ CG P G + S ++G T +F C +EL G A CQ N WS
Sbjct: 512 SYEEIEQGSCGDPGIPAYGRREGSRF--HHGDTLKFECQPAFELVGQKAITCQKNNQWSA 569
Query: 313 TEPTC 317
+P C
Sbjct: 570 KKPGC 574
Score = 43.9 bits (102), Expect = 3e-04
Identities = 52/245 (21%), Positives = 88/245 (35%), Gaps = 48/245 (19%)
Query: 116 KQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYT-LKGERTVTCM---DNKAWSGRP 171
+ CP +P NG + D S + C G+ +G T+TC+ + W+
Sbjct: 687 RHNECPDPGVPVNGK-RFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAV 745
Query: 172 ASCVDMEPPRIKCPS---------------------VKERIAEPNKLT-----VRVSWET 205
C + PS ++ + P K+T V+++T
Sbjct: 746 LRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVNYDT 805
Query: 206 PEGRDTADGILTDVILKGLPPGSNFPE---GDHKIQYTVYDRAENKGTCKFRVK-----V 257
E RD G L G+ G+ P+ Y ++ ++ F+++ +
Sbjct: 806 LEVRD---GRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITL 862
Query: 258 RVKRCGKLNAPENGYMKCSSDGDNY--GATCEFSCIGGYELQGSPARVCQSNLAWSGTEP 315
+ C P NG G+++ GA FSC GY L C+ N WS P
Sbjct: 863 QSDHCLDPGIPVNG----QRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALP 918
Query: 316 TCAAM 320
+C A+
Sbjct: 919 SCEAL 923
Score = 41.2 bits (95), Expect = 0.002
Identities = 48/236 (20%), Positives = 81/236 (34%), Gaps = 39/236 (16%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTC--MDNK-AWSGRPASCVD 176
C +P NG + D + C PGY L+G ++C ++N+ W P +C+
Sbjct: 1385 CNDPGIPQNGS-RSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTCIA 1443
Query: 177 MEPPRIKCPS---VKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNF--- 230
+ PS + EP W+ D ++ ++ L PG +F
Sbjct: 1444 PCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIF--NLEPGYDFLHI 1501
Query: 231 PEGDHKIQYTV-----------YDRAENKGTCKFRVKVRVKRCG-KLNAPENGYMKCSSD 278
+G + + + + N FR V G ++ EN C
Sbjct: 1502 YDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRESCFDP 1561
Query: 279 GD-----------NYGATCEFSCIGGYELQGSPARVC----QSNLAWSGTEPTCAA 319
G G++ + C GGYE++G+ C W+ P C A
Sbjct: 1562 GSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTA 1617
Score = 39.3 bits (90), Expect = 0.008
Identities = 19/58 (32%), Positives = 29/58 (50%), Gaps = 3/58 (5%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDN--KAWSGRPASCV 175
CP A+P+NG K + N + C PGY L+G ++CM + W+ P C+
Sbjct: 1909 CPEPAVPSNG-VKTGERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNYPPPLCI 1965
Score = 36.6 bits (83), Expect = 0.050
Identities = 18/62 (29%), Positives = 30/62 (48%), Gaps = 5/62 (8%)
Query: 116 KQKRCPTLAMPANGGFKCVDGAYFN--SRCEYYCSPGYTLKGERTVTCMDNKAWSGRPAS 173
+Q C +PA G +G+ F+ ++ C P + L G++ +TC N WS +
Sbjct: 517 EQGSCGDPGIPAYGRR---EGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPG 573
Query: 174 CV 175
CV
Sbjct: 574 CV 575
Score = 35.0 bits (79), Expect = 0.14
Identities = 22/76 (28%), Positives = 32/76 (42%), Gaps = 6/76 (7%)
Query: 262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQS----NLAWSGTEPTC 317
C PE G K G++ +F+C GY+LQGS C AWS P C
Sbjct: 343 CPDPGIPERG--KRLGSDFRLGSSVQFTCNEGYDLQGSKRITCMKVSDMFAAWSDHRPVC 400
Query: 318 AAMNVNVGVRTAAALL 333
A + +R + ++
Sbjct: 401 RARMCDAHLRGPSGII 416
Score = 35.0 bits (79), Expect = 0.14
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 4/56 (7%)
Query: 266 NAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC----QSNLAWSGTEPTC 317
+ PE Y K + GA F C GY LQGSP C + W+ + PTC
Sbjct: 1737 SVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC 1792
Score = 35.0 bits (79), Expect = 0.14
Identities = 16/41 (39%), Positives = 20/41 (48%), Gaps = 2/41 (4%)
Query: 279 GDNYGATCEFSCIGGYELQGSPARVCQ--SNLAWSGTEPTC 317
G N G + F C+ GY+L G P CQ +N W P C
Sbjct: 2138 GYNVGQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKC 2178
Score = 31.2 bits (69), Expect = 2.1
Identities = 19/53 (35%), Positives = 21/53 (39%), Gaps = 2/53 (3%)
Query: 283 GATCEFSCIGGYELQGSPARVCQS--NLAWSGTEPTCAAMNVNVGVRTAAALL 333
G T FSC GY L+G+ C WS P C A N T LL
Sbjct: 1058 GDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLL 1110
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 90.9 bits (224), Expect = 2e-18
Identities = 59/203 (29%), Positives = 91/203 (44%), Gaps = 13/203 (6%)
Query: 63 KYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCP 121
K+G + C + Y T C + C +GY L GS L CQ N +W + C ++ C
Sbjct: 445 KHGHISCSTREMLYKTT-----CLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCS 499
Query: 122 TLAMPAN---GGFKC-VDGAYFNSRCEYYCSPGYTLKG-ERTVTCMDNKAWSG--RPASC 174
T MP + C A F + C C G+ L G + + C + W+ + A C
Sbjct: 500 TFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVC 559
Query: 175 VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGD 234
D+E P+I CP E + + V+W+ P +D + ++ + P FP GD
Sbjct: 560 KDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPYLFPIGD 619
Query: 235 HKIQYTVYDRAENKGTCKFRVKV 257
I YT D + N+ +C F +KV
Sbjct: 620 VAIVYTATDLSGNQASCIFHIKV 642
Score = 82.8 bits (203), Expect = 6e-16
Identities = 76/273 (27%), Positives = 112/273 (41%), Gaps = 46/273 (16%)
Query: 54 TPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWS-DK 112
+P C I K + G T L T C GY L+G+ CQ +K W D+
Sbjct: 2767 SPRCEAISCKKPNPVMNGSIKGSNYTYLSTLY-YECDPGYVLNGTERRTCQDDKNWDEDE 2825
Query: 113 VICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPA 172
IC C + + ANG + D F EY C+ G+ L+G R+ C+ N +WSG
Sbjct: 2826 PICIPVDCSSPPVSANGQVRG-DEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATP 2884
Query: 173 SCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDV--------ILKGL 224
CV + R A P +L V+ EG D G + +V IL G
Sbjct: 2885 DCVPV------------RCATPPQLANGVT----EGLDY--GFMKEVTFHCHEGYILHGA 2926
Query: 225 PPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGA 284
P + +G+ + + CK CG +G+ S +G
Sbjct: 2927 PKLTCQSDGNWDAEIPL---------CK------PVNCGPPEDLAHGFPNGFS--FIHGG 2969
Query: 285 TCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
++ C GY+L G+ +R C SN +WSG+ P+C
Sbjct: 2970 HIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSC 3002
Score = 79.0 bits (193), Expect = 9e-15
Identities = 64/265 (24%), Positives = 111/265 (41%), Gaps = 44/265 (16%)
Query: 82 GTRCDIRCQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGAYFN 140
G++ ++ C G++L G+ + C + +W+ + C++ C + P GF D Y
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCG-VPPPLENGFHSADDFYAG 1709
Query: 141 SRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVR 200
S Y C+ GY L G+ + C DN +W+G SC+D++ +C + + L V
Sbjct: 1710 STVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVD----ECAVGSDCSEHASCLNVD 1765
Query: 201 VSW-------ETPEGRDTADGILTDVILKGLPPGSNFPEGDH----------KIQYTVYD 243
S+ T +G++ A+ I K PG+ PE H ++ ++ +
Sbjct: 1766 GSYICSCVPPYTGDGKNCAEPI------KCKAPGN--PENGHSSGEIYTVGAEVTFSCQE 1817
Query: 244 RAENKGTCKFRV-----------KVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIG 292
+ G K + CGK PENG ++ +G+ + C
Sbjct: 1818 GYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIE--ELAFTFGSKVTYRCNK 1875
Query: 293 GYELQGSPARVCQSNLAWSGTEPTC 317
GY L G C +N +WS + P C
Sbjct: 1876 GYTLAGDKESSCLANSSWSHSPPVC 1900
Score = 76.3 bits (186), Expect = 6e-14
Identities = 42/139 (30%), Positives = 63/139 (45%), Gaps = 12/139 (8%)
Query: 67 VYCRA---PQGGYY-----KTALGTRCDIRCQKGYELHGSSLLICQSNKRWS-DKVICKQ 117
V+C A P+ GY+ C +RC G++L GSS+++C N WS + C+
Sbjct: 376 VHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRV 435
Query: 118 KRCPTLAMPANGGFKC-VDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVD 176
+ CP L P +G C + + C C GY L+G +TC N W G CV+
Sbjct: 436 RTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVE 495
Query: 177 MEPPRIKCPSVKERIAEPN 195
+ P K+ I P+
Sbjct: 496 RHCSTFQMP--KDVIISPH 512
Score = 72.0 bits (175), Expect = 1e-12
Identities = 65/252 (25%), Positives = 92/252 (36%), Gaps = 66/252 (26%)
Query: 89 CQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTLAMPANG---GFKCVDGAYFNSRCE 144
C +GY LHG+ L CQS+ W ++ +CK C A+G GF + G + +
Sbjct: 2917 CHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHI----Q 2972
Query: 145 YYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWE 204
Y C PGY L G + C+ N +WSG SC+ P R P ++ +
Sbjct: 2973 YQCFPGYKLHGNSSRRCLSNGSWSGSSPSCL---PCRCSTPVIE--------------YG 3015
Query: 205 TPEGRDTADGILTDV------ILKGLPP---------GSNFPEGDHKIQYTVYDRAENKG 249
T G D G + L GL S FP +H
Sbjct: 3016 TVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEH-------------- 3061
Query: 250 TCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA 309
CG L N ++ +S T +SC GY +QGS +C
Sbjct: 3062 ----------TSCGSLPMIPNAFISETSSWKENVIT--YSCRSGYVIQGSSDLICTEKGV 3109
Query: 310 WSGTEPTCAAMN 321
WS P C ++
Sbjct: 3110 WSQPYPVCEPLS 3121
Score = 71.2 bits (173), Expect = 2e-12
Identities = 61/240 (25%), Positives = 93/240 (38%), Gaps = 35/240 (14%)
Query: 82 GTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTLAMPANGGFKCVDGAYFN 140
GT C GYEL G+ +LICQ + W+ C C P NG + + +
Sbjct: 2678 GTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPENGFLRFTETS-MG 2736
Query: 141 SRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC--VDMEPPRIKCPSVKERIAEPNKLT 198
S +Y C PG+ L G C++N+ WSG C + + P P + I N
Sbjct: 2737 SAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPN---PVMNGSIKGSNYTY 2793
Query: 199 V-RVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKV 257
+ + +E G +L + N+ E D I V
Sbjct: 2794 LSTLYYECDPGY-----VLNGTERRTCQDDKNWDE-DEPICIPV---------------- 2831
Query: 258 RVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
C NG ++ D + E++C G+ L+G+ +RVC +N +WSG P C
Sbjct: 2832 ---DCSSPPVSANGQVR--GDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDC 2886
Score = 70.9 bits (172), Expect = 2e-12
Identities = 63/258 (24%), Positives = 97/258 (37%), Gaps = 33/258 (12%)
Query: 66 DVYCRAPQGGYYKTALGTRCDIRCQKGYELHG-SSLLICQSNKRWSDKV---ICKQKRCP 121
DV G GT C + C++G+ L G +L C ++ +W+ V +CK P
Sbjct: 506 DVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKEMLRCTTSGKWNVGVQAAVCKDVEAP 565
Query: 122 TLAMPANGGFKCVD------------------GAYFNSRCEYYCSPGYTLKGERTVTCMD 163
+ P + K ++ G + +P Y
Sbjct: 566 QINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEKVSVHVHPAFTPPYLFPIGDVAIVYT 625
Query: 164 NKAWSGRPASCV------DMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILT 217
SG ASC+ D EPP I + K+ SW+ P+ D + L
Sbjct: 626 ATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQVSEKVHA-ASWDEPQFSDNSGAEL- 683
Query: 218 DVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSS 277
VI + G FP+G+ +QYT D + N TC + ++ C P NG C+
Sbjct: 684 -VITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHIVIKGSPCEIPFTPVNGDFICTP 742
Query: 278 DGDNYGATCEFSCIGGYE 295
DN G C +C+ GY+
Sbjct: 743 --DNTGVNCTLTCLEGYD 758
Score = 70.9 bits (172), Expect = 2e-12
Identities = 66/268 (24%), Positives = 112/268 (41%), Gaps = 47/268 (17%)
Query: 67 VYCRAP--------QGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQ 117
+ C+AP G Y +G CQ+GY+L G + + C + W+ + CK
Sbjct: 1787 IKCKAPGNPENGHSSGEIY--TVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKA 1844
Query: 118 KRCPTLAMPANGGFKCVD--GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
C A+P NG C++ F S+ Y C+ GYTL G++ +C+ N +WS P C
Sbjct: 1845 VSCGKPAIPENG---CIEELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVC- 1900
Query: 176 DMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGR--DTADGILTDVILKGLPPGSNFPEG 233
EP +KC S E I + +++ + DT + I++ G
Sbjct: 1901 --EP--VKCSS-PENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASG------ 1949
Query: 234 DHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGG 293
++DRA F CG+ A ++ + + + + T ++C G
Sbjct: 1950 -------IWDRAPPACHLVF--------CGEPPAIKDAVI--TGNNFTFRNTVTYTCKEG 1992
Query: 294 YELQGSPARVCQSNLAWSGTEPTCAAMN 321
Y L G C ++ WS ++ C A++
Sbjct: 1993 YTLAGLDTIECLADGKWSRSDQQCLAVS 2020
Score = 70.9 bits (172), Expect = 2e-12
Identities = 70/281 (24%), Positives = 115/281 (40%), Gaps = 56/281 (19%)
Query: 56 WCSPIKVKYGDVYCRAP---QGGYYKTALG----TRCDIRCQKGYELHGSSLLICQSNKR 108
W SPI + V C P + G+ + G + +C GY+ GS + +CQ+N+
Sbjct: 2192 WSSPIPTCH-PVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRH 2250
Query: 109 WSDK--VICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKA 166
W + ++C C P GF + S+ +++C+ GY L G+ + TC +
Sbjct: 2251 WHSESPLMCVPLDCGK-PPPIQNGFMKGENFEVGSKVQFFCNEGYELVGDSSWTCQKSGK 2309
Query: 167 WSGR------PASCVDMEPPRIKCPSV-KERIAEPNKLTVRVSWETPEGRDTADGILTDV 219
W+ + PA C EPP ++ V KE E +T + EG +
Sbjct: 2310 WNKKSNPKCMPAKC--PEPPLLENQLVLKELTTEVGVVT----FSCKEGH----VLQGPS 2359
Query: 220 ILKGLPP---GSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCS 276
+LK LP +FP CK + C G +
Sbjct: 2360 VLKCLPSQQWNDSFP------------------VCK------IVLCTPPPLISFG-VPIP 2394
Query: 277 SDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
S ++G+T ++SC+GG+ L+G+ +CQ + WS P C
Sbjct: 2395 SSALHFGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPEC 2435
Score = 69.7 bits (169), Expect = 5e-12
Identities = 83/357 (23%), Positives = 135/357 (37%), Gaps = 57/357 (15%)
Query: 10 LLLLLPPLLLLLLLRVPPSRSFPGS-------GDSPLEDDEVGYSHPRYKDTPWCSPIKV 62
++L PP L+ + +P S GS G L + P D W SP+
Sbjct: 2378 IVLCTPPPLISFGVPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQP---DGTWSSPLP- 2433
Query: 63 KYGDVYCRAPQG-----------GYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRW-S 110
+ V C P+ Y TAL T C+ G+EL G++ +C N W
Sbjct: 2434 ECVPVECPQPEEIPNGIIDVQGLAYLSTALYT-----CKPGFELVGNTTTLCGENGHWLG 2488
Query: 111 DKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGR 170
K CK C NG F D ++ Y C+ G+ L+G +TC++ W
Sbjct: 2489 GKPTCKAIECLKPKEILNGKFSYTD-LHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVD 2547
Query: 171 PASCVDMEPPRIKCPS---VKERIAE---------------PNKLTVRVSWETPEGRDTA 212
SC I C S ++ E P + +T E +
Sbjct: 2548 APSC-----NAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWS 2602
Query: 213 DGILTDVILK-GLPPGSNFPEGDH-KIQYTVYDRAENKGTCKFRVKVRVKRCGKL-NAPE 269
I T + + GLPP +F + K +++ ++ + G + E
Sbjct: 2603 SSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWE 2662
Query: 270 NGYMKCSSDGDN--YGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAMNVNV 324
N ++ N YG ++C GYEL G+P +CQ + W+G+ P+C ++ ++
Sbjct: 2663 NTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDL 2719
Score = 68.6 bits (166), Expect = 1e-11
Identities = 71/258 (27%), Positives = 105/258 (40%), Gaps = 32/258 (12%)
Query: 89 CQKGYELHGSSLLICQSNKRWS-DKVICKQKRCPTLAMPANGGFKCVDGAYFN--SRCEY 145
C +G+ L G S L C W D C C + P GF V+GA ++ + Y
Sbjct: 2524 CNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDS-PQPIENGF--VEGADYSYGAIIIY 2580
Query: 146 YCSPGYTLKGERTVTCMDNKAWSGRPASCVDME---PPRIK---CPSVKERIA--EPNKL 197
C PG+ + G TC + WS +C+ ++ PP I C +K+ E
Sbjct: 2581 SCFPGFQVAGHAMQTC-EESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDD 2639
Query: 198 TVRVSWETPEGRDTADGIL-TDVILKGLPP--GSNFPEGDHKIQYTV---YDRAENK--- 248
+ V + TP + T K P SNF G + YT Y+ N
Sbjct: 2640 MMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGT-MVSYTCNPGYELLGNPVLI 2698
Query: 249 ----GTCKFRVKVRVK-RCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARV 303
GT + C APENG+++ + + G+ ++SC G+ L GS R+
Sbjct: 2699 CQEDGTWNGSAPSCISIECDLPTAPENGFLRFTET--SMGSAVQYSCKPGHILAGSDLRL 2756
Query: 304 CQSNLAWSGTEPTCAAMN 321
C N WSG P C A++
Sbjct: 2757 CLENRKWSGASPRCEAIS 2774
Score = 67.4 bits (163), Expect = 3e-11
Identities = 77/289 (26%), Positives = 111/289 (38%), Gaps = 55/289 (19%)
Query: 45 GYSHPRYKDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDI------RCQKGYELHGS 98
G P + D CSP+ C P+ + +G++ +C+ GYEL G+
Sbjct: 3225 GTWEPPFSDES-CSPVS-------CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGN 3276
Query: 99 SLLICQSNKRWSDKV-ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGER 157
+CQ N++WS V ICK+ RC T NG ++ Y C+ GY+L+G
Sbjct: 3277 RERVCQENRQWSGGVAICKETRCETPLEFLNGKAD-IENRTTGPNVVYSCNRGYSLEGPS 3335
Query: 158 TVTCMDNKAWSG-----RPASC-VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDT 211
C +N WS +P C V P S KE + N VS + EG
Sbjct: 3336 EAHCTENGTWSHPVPLCKPNPCPVPFVIPENALLSEKEFYVDQN-----VSIKCREG--- 3387
Query: 212 ADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENG 271
+L+G H I D + + K K+ CG EN
Sbjct: 3388 -------FLLQG-----------HGIITCNPDETWTQTSAKCE-KI---SCGPPAHVENA 3425
Query: 272 YMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAM 320
+ YG +SC GY L+G VC N W+ + P C A+
Sbjct: 3426 IAR--GVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWT-SPPICRAV 3471
Score = 65.5 bits (158), Expect = 1e-10
Identities = 60/235 (25%), Positives = 87/235 (37%), Gaps = 30/235 (12%)
Query: 89 CQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYC 147
C++G+ L G S+L C +++W+D +CK C + + G +F S +Y C
Sbjct: 2349 CKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHFGSTVKYSC 2408
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPE 207
G+ L+G T C + WS CV +E CP + E P
Sbjct: 2409 VGGFFLRGNSTTLCQPDGTWSSPLPECVPVE-----CPQPE---------------EIPN 2448
Query: 208 GRDTADGI-LTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLN 266
G G+ L PG + K TCK C K
Sbjct: 2449 GIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGKPTCK------AIECLKPK 2502
Query: 267 APENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAMN 321
NG K S +YG T +SC G+ L+G A C W P+C A++
Sbjct: 2503 EILNG--KFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIH 2555
Score = 61.6 bits (148), Expect = 1e-09
Identities = 73/320 (22%), Positives = 112/320 (35%), Gaps = 75/320 (23%)
Query: 55 PWCSPIKVKYGDVYCRAPQ----GGYYKTALG--TRCDIRCQKGYELHGSSLLICQSNKR 108
P C P+K C +P+ G Y + L + C GY L G S++ C ++
Sbjct: 1898 PVCEPVK-------CSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGI 1950
Query: 109 WSDK------VICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCM 162
W V C + A+ F F + Y C GYTL G T+ C+
Sbjct: 1951 WDRAPPACHLVFCGEPPAIKDAVITGNNFT------FRNTVTYTCKEGYTLAGLDTIECL 2004
Query: 163 DNKAWSGRPASCVDM---EPPRI--KCPSVKER---------------IAEPNKL--TVR 200
+ WS C+ + EPP + P R +A+ ++L +
Sbjct: 2005 ADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFGDIAFYYCSDGYSLADNSQLLCNAQ 2064
Query: 201 VSWETPEGRDTADGILTDVILKGLPPGSNFP--EGDHKIQYTVYDRAENKGTCKFRVKVR 258
W PEG+D I PP ++ E K ++ K F +
Sbjct: 2065 GKWVPPEGQDMPRCI---AHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTS 2121
Query: 259 VK---------------------RCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQ 297
K RCG+ + NGY S ++GA +SC G+ ++
Sbjct: 2122 AKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGY--ASGSNYSFGAMVAYSCNKGFYIK 2179
Query: 298 GSPARVCQSNLAWSGTEPTC 317
G C++ WS PTC
Sbjct: 2180 GEKKSTCEATGQWSSPIPTC 2199
Score = 60.5 bits (145), Expect = 3e-09
Identities = 65/281 (23%), Positives = 93/281 (33%), Gaps = 60/281 (21%)
Query: 58 SPIKVKYGDVYCRAP---QGGYYKTA---LGTRCDIRCQKGYELHGSSLLICQSNKRWSD 111
SP+ ++ V C P GY + G C KG+ + G C++ +WS
Sbjct: 2135 SPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSS 2194
Query: 112 KV-ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAW-SG 169
+ C C NG + G F S Y C+PGY G C N+ W S
Sbjct: 2195 PIPTCHPVSCGEPPKVENGFLEHTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSE 2254
Query: 170 RPASCVDME---PPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPP 226
P CV ++ PP I+ G
Sbjct: 2255 SPLMCVPLDCGKPPPIQ--------------------------------------NGFMK 2276
Query: 227 GSNFPEGDHKIQYTVYDRAENKG----TCKFRVKVRVK---RCGKLNAPENGYMK---CS 276
G NF G K+Q+ + E G TC+ K K +C PE ++
Sbjct: 2277 GENFEVGS-KVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVL 2335
Query: 277 SDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
+ FSC G+ LQG C + W+ + P C
Sbjct: 2336 KELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVC 2376
Score = 58.2 bits (139), Expect = 2e-08
Identities = 25/60 (41%), Positives = 33/60 (55%)
Query: 258 RVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
RV+ C L P++G++ CS+ Y TC +C GY L+GS CQ N W G EP C
Sbjct: 434 RVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRC 493
Score = 57.8 bits (138), Expect = 2e-08
Identities = 59/251 (23%), Positives = 96/251 (38%), Gaps = 44/251 (17%)
Query: 78 KTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD---KVICKQKRCPTLAMPANGGFKCV 134
K A G+ +C +G+ L+ S+ + C +W+ + C RC N G+
Sbjct: 2101 KFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMN-GYASG 2159
Query: 135 DGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSG-----RPASCVDMEPPRIKCPSVKE 189
F + Y C+ G+ +KGE+ TC WS P SC EPP+++ ++
Sbjct: 2160 SNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSC--GEPPKVENGFLEH 2217
Query: 190 RIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKG 249
+ VR P + + Q + +E+
Sbjct: 2218 TTGRIFESEVRYQC-NPGYKSVGSPVFV-------------------CQANRHWHSESPL 2257
Query: 250 TCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNY--GATCEFSCIGGYELQGSPARVCQSN 307
C CGK +NG+MK G+N+ G+ +F C GYEL G + CQ +
Sbjct: 2258 MCV------PLDCGKPPPIQNGFMK----GENFEVGSKVQFFCNEGYELVGDSSWTCQKS 2307
Query: 308 LAWS-GTEPTC 317
W+ + P C
Sbjct: 2308 GKWNKKSNPKC 2318
Score = 57.4 bits (137), Expect = 3e-08
Identities = 58/244 (23%), Positives = 86/244 (35%), Gaps = 51/244 (20%)
Query: 89 CQKGYELHGSSLLICQSNKRW-----SDKVICKQKRCPTLAMPANGGFKCVDGAYF--NS 141
C GY L +S L+C + +W D C C + + V A F S
Sbjct: 2047 CSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGS 2106
Query: 142 RCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRV 201
+ C G+ L + CM W+ P S I+C V R EP
Sbjct: 2107 VVSFKCMEGFVLNTSAKIECMRGGQWNPSPMS--------IQCIPV--RCGEPPS----- 2151
Query: 202 SWETPEGRDTADGILTDVILKGLPPGSNFPEGD---HKIQYTVYDRAENKGTCKFRVK-- 256
I+ G GSN+ G + Y + E K TC+ +
Sbjct: 2152 ------------------IMNGYASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWS 2193
Query: 257 -----VRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWS 311
CG+ ENG+++ ++ G + + + C GY+ GSP VCQ+N W
Sbjct: 2194 SPIPTCHPVSCGEPPKVENGFLEHTT-GRIFESEVRYQCNPGYKSVGSPVFVCQANRHWH 2252
Query: 312 GTEP 315
P
Sbjct: 2253 SESP 2256
Score = 55.8 bits (133), Expect = 8e-08
Identities = 31/99 (31%), Positives = 45/99 (45%), Gaps = 6/99 (6%)
Query: 80 ALGTRCDIRCQKGYELHGSSLLICQSNKRW----SDKVICKQKRCPTLAMPANGGFKCVD 135
++ + + C +GY G ++ +CQ + W SD+ C C P +G F
Sbjct: 3198 SVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDES-CSPVSCGKPESPEHG-FVVGS 3255
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 174
F S Y C PGY L+G R C +N+ WSG A C
Sbjct: 3256 KYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAIC 3294
Score = 55.5 bits (132), Expect = 1e-07
Identities = 62/279 (22%), Positives = 91/279 (32%), Gaps = 55/279 (19%)
Query: 52 KDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD 111
+D P C P+ V G T + C +G+ L G+ +C +N WS
Sbjct: 2823 EDEPICIPVDCSSPPVSANGQVRGDEYT-FQKEIEYTCNEGFLLEGARSRVCLANGSWSG 2881
Query: 112 KVI-CKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGR 170
C RC T ANG + +D F ++C GY L G +TC + W
Sbjct: 2882 ATPDCVPVRCATPPQLANGVTEGLDYG-FMKEVTFHCHEGYILHGAPKLTCQSDGNWDAE 2940
Query: 171 PASC--VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGS 228
C V+ PP + + G P G
Sbjct: 2941 IPLCKPVNCGPP-------------------------------------EDLAHGFPNGF 2963
Query: 229 NFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGA---- 284
+F G H IQY + + G R G ++P +CS+ YG
Sbjct: 2964 SFIHGGH-IQYQCFPGYKLHGNSSRRCLSNGSWSG--SSPSCLPCRCSTPVIEYGTVNGT 3020
Query: 285 ------TCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
C G++L G C+++ WS P C
Sbjct: 3021 DFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHC 3059
Score = 52.0 bits (123), Expect = 1e-06
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 102 ICQSNKRWSDKVICKQKRCPTLAMPANGGF-KCVDGAYFNSRCEYYCSPGYTLKGERTVT 160
+C+ R S + C+ CP L P NG F + +FN+ C C PG+ L G +
Sbjct: 361 VCREGYRASGQT-CELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIIL 419
Query: 161 CMDNKAWSGRPASCVDMEPPRIKCP 185
C+ N WSG + C P ++ P
Sbjct: 420 CLPNGLWSGSESYCRVRTCPHLRQP 444
Score = 51.2 bits (121), Expect = 2e-06
Identities = 63/247 (25%), Positives = 90/247 (36%), Gaps = 46/247 (18%)
Query: 77 YKTALGTRCD------IRCQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANG 129
Y T GT D I+C KG++L G S + C+++ +WS C+ C +L M N
Sbjct: 3014 YGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNA 3073
Query: 130 GFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKC---PS 186
F ++ + Y C GY ++G + C + WS C EP + C PS
Sbjct: 3074 -FISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVC---EP--LSCGSPPS 3127
Query: 187 VKERIA--EPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDR 244
V +A E + V EG T K G FPE
Sbjct: 3128 VANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQK---DGRWFPE------------ 3172
Query: 245 AENKGTCKFRVKVRVKRCGKLNAPEN-GYMKCSSDGDNYGATCEFSCIGGYELQGSPARV 303
R+ K+C PEN ++ D + SC GY +G V
Sbjct: 3173 ---------RISCSPKKC---PLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISV 3220
Query: 304 CQSNLAW 310
CQ + W
Sbjct: 3221 CQLDGTW 3227
Score = 48.5 bits (114), Expect = 1e-05
Identities = 29/93 (31%), Positives = 40/93 (43%), Gaps = 10/93 (10%)
Query: 225 PPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGA 284
PPGS PE D +G + C L PENGY ++ +++ A
Sbjct: 351 PPGSTSPE----------DCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNA 400
Query: 285 TCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
C C G++L GS +C N WSG+E C
Sbjct: 401 ACGVRCHPGFDLVGSSIILCLPNGLWSGSESYC 433
Score = 29.6 bits (65), Expect = 6.1
Identities = 17/75 (22%), Positives = 34/75 (45%), Gaps = 4/75 (5%)
Query: 254 RVKVRVKRCGKLNAPENG----YMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA 309
+VK+ K + P G +++ +S+ G+ C G++L G+P + C +
Sbjct: 1618 KVKIDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQ 1677
Query: 310 WSGTEPTCAAMNVNV 324
W+ P C ++ V
Sbjct: 1678 WTQPLPHCERISCGV 1692
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 85.5 bits (210), Expect = 9e-17
Identities = 79/278 (28%), Positives = 115/278 (41%), Gaps = 43/278 (15%)
Query: 61 KVKYGDVYCRAPQ----GGYYKT---ALGTRCDIRCQKGYELHGSSLLICQSNK----RW 109
K++Y YC GG A+G++ C+ GY + G S C+ N +W
Sbjct: 2425 KIRYAAPYCSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQW 2484
Query: 110 SDKV-ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGER--TVTCMDNKA 166
+C+ C P NG F + +S+ Y C G+ L+ + T C ++
Sbjct: 2485 DSLTPLCQAVSCGIPESPGNGSFTGNEFT-LDSKVVYECHEGFKLESSQQATAVCQEDGL 2543
Query: 167 WS--GRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGL 224
WS G+P +C + CPS++ +++E V W G G +L
Sbjct: 2544 WSNKGKPPTCKP-----VACPSIEAQLSE------HVIWRLVSGSLNEYGAQ---VLLSC 2589
Query: 225 PPGSNFPEGDHKIQYTVYDRAENKGTCKF---RVKVRVKRCGKLNAPENGYMKCSSDGDN 281
PG + EG + R + GT R RV CG L+ P NG +
Sbjct: 2590 SPGY-YLEGWRLL------RCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLTV-- 2640
Query: 282 YGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAA 319
YGAT F+C GY L GS R C +N WSG+E C A
Sbjct: 2641 YGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLA 2678
Score = 72.4 bits (176), Expect = 8e-13
Identities = 68/267 (25%), Positives = 98/267 (36%), Gaps = 42/267 (15%)
Query: 89 CQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYC 147
C+ G++L GS C N WS + +C+ C P NG DG F+S Y C
Sbjct: 2947 CEMGHQLRGSPERTCLLNGSWSGLQPVCEAVSCGNPGTPTNGMIVSSDGILFSSSVIYAC 3006
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASC--VDMEPPRIKCPSVKERIAEPNKLTVRVSWET 205
GY G T C N W+G C + P + + VS++
Sbjct: 3007 WEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANGI--QFGTDFTFNKTVSYQC 3064
Query: 206 PEG-----------RDTADG-------ILTDVILKGLPP-------GSNFPEGD------ 234
G R T DG + V+ PP GS+F G
Sbjct: 3065 NPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSC 3124
Query: 235 ---HKIQYTVYDRAENKGTCKFRV-KVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSC 290
+++ ++ E +G K + + CG P G + S Y + F C
Sbjct: 3125 MDGYQLSHSAILSCEGRGVWKGEIPQCLPVFCGDPGIPAEG--RLSGKSFTYKSEVFFQC 3182
Query: 291 IGGYELQGSPARVCQSNLAWSGTEPTC 317
+ L GS RVCQ++ WSG +PTC
Sbjct: 3183 KSPFILVGSSRRVCQADGTWSGIQPTC 3209
Score = 65.9 bits (159), Expect = 8e-11
Identities = 60/239 (25%), Positives = 87/239 (36%), Gaps = 35/239 (14%)
Query: 89 CQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGAYFN--SRCEY 145
C+KG+ L GSS L C +N W + C C +PAN + G F + Y
Sbjct: 2828 CKKGFYLLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANA---VLTGELFTYGAVVHY 2884
Query: 146 YCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVK---ERIAEPNKLTVRVS 202
C +L G T C ++ WSG C P P R+ + K +
Sbjct: 2885 SCRGSESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLR 2944
Query: 203 WETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRC 262
+ G L+G P + G V + C
Sbjct: 2945 FSCEMGHQ----------LRGSPERTCLLNGSWSGLQPVCEAVS---------------C 2979
Query: 263 GKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAMN 321
G P NG M SSDG + ++ ++C GY+ G R C +N W+GT P C ++
Sbjct: 2980 GNPGTPTNG-MIVSSDGILFSSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIIS 3037
Score = 64.3 bits (155), Expect = 2e-10
Identities = 72/280 (25%), Positives = 102/280 (36%), Gaps = 44/280 (15%)
Query: 54 TPWCSPIKVKY-GDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDK 112
TP C PI + G+ G + L + C GY L G S C+SN +WS
Sbjct: 2731 TPVCVPITCGHPGNPAHGFTNGSEFN--LNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSP 2788
Query: 113 V-ICKQKRCPTLAMPAN----GGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAW 167
+ C+ C N G + + Y+C G+ L G +TCM N W
Sbjct: 2789 LPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLW 2848
Query: 168 SGRPASCVDMEPPRIKC--PSVKERIAEPNKLTV--RVSWETPEGRDTADGILTDVILKG 223
C+ I C P V +L V + G ++ G T V
Sbjct: 2849 DRSLPKCL-----AISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTRVC--- 2900
Query: 224 LPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYG 283
E H + N G C G P +G S GD++
Sbjct: 2901 -------QEDSHWSGALPHCTGNNPGFC-----------GDPGTPAHG----SRLGDDFK 2938
Query: 284 --ATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAMN 321
+ FSC G++L+GSP R C N +WSG +P C A++
Sbjct: 2939 TKSLLRFSCEMGHQLRGSPERTCLLNGSWSGLQPVCEAVS 2978
Score = 56.6 bits (135), Expect = 5e-08
Identities = 62/264 (23%), Positives = 92/264 (34%), Gaps = 31/264 (11%)
Query: 79 TALGTRCDIRCQKGYELHGSSLLICQSNKRWS-DKVICKQKRCPTLAMPANGGFKCVDGA 137
T G C GY L GS + C +N WS + C C + NG DG
Sbjct: 2639 TVYGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISG-DGF 2697
Query: 138 YFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKL 197
+ Y C+PG+ L G C+ + WSG+ CV + P+ L
Sbjct: 2698 SYRDTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNL 2757
Query: 198 TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKV 257
V++ G +L+G+ G + TC
Sbjct: 2758 NDVVNFTCNTG----------YLLQGVSRAQCRSNGQW---------SSPLPTC------ 2792
Query: 258 RVKRCGKLNAPENGY---MKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTE 314
RV C EN + + YG + + C G+ L GS A C +N W +
Sbjct: 2793 RVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSL 2852
Query: 315 PTCAAMNV-NVGVRTAAALLDQFY 337
P C A++ + GV A L + +
Sbjct: 2853 PKCLAISCGHPGVPANAVLTGELF 2876
Score = 53.9 bits (128), Expect = 3e-07
Identities = 29/96 (30%), Positives = 43/96 (44%), Gaps = 2/96 (2%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDGAYF 139
+G+ RC+KGY + GS+ C +N WS + C C PA+ + +D F
Sbjct: 3236 VGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTF 3295
Query: 140 NSRCEYYCSPGYTLK-GERTVTCMDNKAWSGRPASC 174
Y C PG+ L G TC + W+G+ C
Sbjct: 3296 GYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVC 3331
Score = 53.1 bits (126), Expect = 5e-07
Identities = 67/283 (23%), Positives = 103/283 (36%), Gaps = 40/283 (14%)
Query: 52 KDTPWCSPIKVKYGDVYCRAP---QGGYYKTA---LGTRCDIRCQKGYELHGSSLLICQS 105
KD W +P K V C P Q G + + G+ C GY+L S++L C+
Sbjct: 3082 KDGRW-NPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAILSCEG 3140
Query: 106 NKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDN 164
W ++ C C +PA G Y S + C + L G C +
Sbjct: 3141 RGVWKGEIPQCLPVFCGDPGIPAEGRLSGKSFTY-KSEVFFQCKSPFILVGSSRRVCQAD 3199
Query: 165 KAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGL 224
WSG +C+D P CP +P TP GI +G
Sbjct: 3200 GTWSGIQPTCID--PAHNTCP-------DPG---------TPH-----FGIQNS--SRGY 3234
Query: 225 PPGSNF----PEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGD 280
GS +G H T N + + C + P + ++ + D
Sbjct: 3235 EVGSTVFFRCRKGYHIQGSTTRTCLANLTWSGIQTECIPHACRQPETPAHADVR-AIDLP 3293
Query: 281 NYGATCEFSCIGGYELQ-GSPARVCQSNLAWSGTEPTCAAMNV 322
+G T ++C G+ L GS R C++++ W+G P C + V
Sbjct: 3294 TFGYTLVYTCHPGFFLAGGSEHRTCKADMKWTGKSPVCKSKGV 3336
Score = 48.9 bits (115), Expect = 1e-05
Identities = 60/240 (25%), Positives = 91/240 (37%), Gaps = 45/240 (18%)
Query: 119 RCPTLAMPANGGFKCVDGAYFNSRCEYY-CSPGYTLKGERTVTCM--DNKAWSGRPASCV 175
+C +P N G++ D +F Y C+PGY + G T+TC+ D + W SC+
Sbjct: 1217 KCEDPGIP-NYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCI 1275
Query: 176 DMEPPRIKCPSVKERIAEP-------NKLTVRVSWETPEGR-----------DTADGIL- 216
+I + RI P N L E G+ + A IL
Sbjct: 1276 AECGGQIHA-ATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILK 1334
Query: 217 -------TDVILKGLPPGSNFPEGDHK------IQY-TVYDRAENKGTCKFRVKVRVKRC 262
+D++LK GS PE H +Q+ + + +++ + +F + C
Sbjct: 1335 VWDGPVDSDILLKEW-SGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSI-AATC 1392
Query: 263 GKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC---QSNLAWSGTEPTCAA 319
P+NG D G T F C GY+LQG C + W PTC A
Sbjct: 1393 NDPGMPQNGTR--YGDSREAGDTVTFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTCIA 1450
Score = 45.1 bits (105), Expect = 1e-04
Identities = 70/284 (24%), Positives = 103/284 (36%), Gaps = 66/284 (23%)
Query: 93 YELHGSS---LLICQSNKRW----SDKVI-----------CKQKRCPTLAMPANGGFKCV 134
Y L GSS L++ SN+ W SD I ++ C +PA G K
Sbjct: 483 YVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYG--KRT 540
Query: 135 DGAYFNS-RCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCV-------DMEPPRIKCPS 186
++ + + C + L GER +TC N WSG SCV I P+
Sbjct: 541 GSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPN 600
Query: 187 VKER-----------IAEP--------NKLTVRVSWETPEGRDTADGILTDVILKGLPPG 227
E I+EP N V ++ +D DGI +D+ + G G
Sbjct: 601 YPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQFDFLAVKD--DGI-SDITVLGTFSG 657
Query: 228 SNFP----EGDH--KIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN 281
+ P H ++++ +G C P NG GD
Sbjct: 658 NEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPING----RRFGDR 713
Query: 282 Y--GATCEFSCIGGY-ELQGSPARVC---QSNLAWSGTEPTCAA 319
+ G++ F C G+ + QGS + C N+ WS T P C A
Sbjct: 714 FLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEA 757
Score = 43.5 bits (101), Expect = 4e-04
Identities = 26/76 (34%), Positives = 34/76 (44%), Gaps = 5/76 (6%)
Query: 262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQ----SNLAWSGTEPTC 317
C PENG + SD GA +FSC Y LQGS + CQ + AWS P C
Sbjct: 349 CPDPGIPENG-RRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPIC 407
Query: 318 AAMNVNVGVRTAAALL 333
A +R + ++
Sbjct: 408 RARTCGSNLRGPSGVI 423
Score = 40.8 bits (94), Expect = 0.003
Identities = 54/248 (21%), Positives = 86/248 (34%), Gaps = 45/248 (18%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQ----SNKRWSD-KVICKQKRCPTLAMPANGGFKCVD 135
+G C+ Y L GS + CQ + WSD + IC+ + C
Sbjct: 368 VGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTC--------------- 412
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
G+ SP Y ++ E C+ W +P ++ + +E E
Sbjct: 413 GSNLRGPSGVITSPNYPVQYEDNAHCV----WV-----ITTTDPDKVIKLAFEEFELERG 463
Query: 196 KLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVY------DRAENKG 249
T+ V G DT + + GS+ P+ + ++ D + G
Sbjct: 464 YDTLTVGDAGKVG-DTRSVLY-------VLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPG 515
Query: 250 TCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA 309
++ CG P Y K + +G T F C +EL G CQ N
Sbjct: 516 FKAVYQEIEKGGCGDPGIP--AYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQ 573
Query: 310 WSGTEPTC 317
WSG +P+C
Sbjct: 574 WSGNKPSC 581
Score = 39.7 bits (91), Expect = 0.006
Identities = 55/246 (22%), Positives = 90/246 (36%), Gaps = 52/246 (21%)
Query: 117 QKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYT-LKGERTVTCM---DNKAWSGRPA 172
Q C +P NG + D S ++C G+ +G ++TC+ N WS
Sbjct: 695 QNECHDPGIPINGR-RFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVP 753
Query: 173 SCVD------------MEPP--------RIKCPSVKERIAEP--------NKLTVRVSWE 204
C + PP + C + E A+P ++ V+++
Sbjct: 754 RCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIE--AKPGHSIKITFDRFQTEVNYD 811
Query: 205 TPEGRDTADGILTDVILKGLPPGSNFPE---GDHKIQYTVYDRAENKGTCKF-----RVK 256
T E RD G + L G G+ P+ Y ++ ++ + F V
Sbjct: 812 TLEVRD---GPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVT 868
Query: 257 VRVKRCGKLNAPENGYMKCSSDGDNYG--ATCEFSCIGGYELQGSPARVCQSNLAWSGTE 314
+ C P NG+ G ++G +T FSC GY L VC+ N W+
Sbjct: 869 LESDSCLDPGIPVNGHRH----GGDFGIRSTVTFSCDPGYTLSDDEPLVCERNHQWNHAL 924
Query: 315 PTCAAM 320
P+C A+
Sbjct: 925 PSCDAL 930
Score = 39.7 bits (91), Expect = 0.006
Identities = 57/239 (23%), Positives = 86/239 (35%), Gaps = 48/239 (20%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDN--KAWSGRPASCVDM 177
C A+P+N K D N + C PGYTL+G ++CM + W+ C+
Sbjct: 1916 CQEPALPSNS-IKIGDRYMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCI-- 1972
Query: 178 EPPRIKCPSVKERI-----------AEPNKL--TVRVSWETPEGR--------------- 209
C + + PN L T R+S G
Sbjct: 1973 ----ATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEANHDF 2028
Query: 210 -DTADGILTDVILKGLPPGSNFPEG----DHKIQYTVY-DRAENKGTCKFRVKV-RVKRC 262
+ +G + G G++ P H+ Y D ++N+ K + ++ C
Sbjct: 2029 LEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNC 2088
Query: 263 GKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQS--NLAWSGTEPTCAA 319
+NGYM +SD + G + F C GY L G P CQ N W+ P C A
Sbjct: 2089 PDPPPFQNGYM-INSD-YSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDA 2145
Score = 38.9 bits (89), Expect = 0.010
Identities = 33/127 (25%), Positives = 47/127 (37%), Gaps = 6/127 (4%)
Query: 52 KDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD 111
+ P C I + V A G T G C+ L G+ +CQ + WS
Sbjct: 2850 RSLPKCLAISCGHPGVPANAVLTGELFT-YGAVVHYSCRGSESLIGNDTRVCQEDSHWSG 2908
Query: 112 KVI-CKQKR---CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAW 167
+ C C PA+G + D S + C G+ L+G TC+ N +W
Sbjct: 2909 ALPHCTGNNPGFCGDPGTPAHGS-RLGDDFKTKSLLRFSCEMGHQLRGSPERTCLLNGSW 2967
Query: 168 SGRPASC 174
SG C
Sbjct: 2968 SGLQPVC 2974
Score = 33.5 bits (75), Expect = 0.42
Identities = 22/76 (28%), Positives = 33/76 (43%), Gaps = 2/76 (2%)
Query: 258 RVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQ--SNLAWSGTEP 315
++K+C A M D G ++ C GY L G+ C+ S L + G+ P
Sbjct: 2255 QLKKCQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLP 2314
Query: 316 TCAAMNVNVGVRTAAA 331
TC A VRT ++
Sbjct: 2315 TCEAQCPANEVRTGSS 2330
Score = 33.1 bits (74), Expect = 0.55
Identities = 35/137 (25%), Positives = 51/137 (37%), Gaps = 21/137 (15%)
Query: 43 EVGYSHPRYKDTPWCS-PIKVKYGDVYCRAPQ----GGYYKTALGTRCDIRCQKGYELHG 97
EV Y +D P S P+ +Y +APQ G + L T + R G+ +H
Sbjct: 807 EVNYDTLEVRDGPASSSPLIGEYHGT--QAPQFLISTGNFMYLLFTTDNSRSSIGFLIHY 864
Query: 98 SSLLICQSNKRWSDKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGER 157
S+ + + C +P NG D S + C PGYTL +
Sbjct: 865 ESVTL-------------ESDSCLDPGIPVNGHRHGGDFG-IRSTVTFSCDPGYTLSDDE 910
Query: 158 TVTCMDNKAWSGRPASC 174
+ C N W+ SC
Sbjct: 911 PLVCERNHQWNHALPSC 927
Score = 33.1 bits (74), Expect = 0.55
Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 4/56 (7%)
Query: 266 NAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQS----NLAWSGTEPTC 317
+ PE Y + + G+ F C GY LQGS A CQS W+ T P+C
Sbjct: 1744 SVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799
Score = 32.3 bits (72), Expect = 0.94
Identities = 16/59 (27%), Positives = 25/59 (42%), Gaps = 4/59 (6%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCM----DNKAWSGRPASC 174
CP +P NG D + + ++ C Y L+G +++TC AWS C
Sbjct: 349 CPDPGIPENGRRAGSDFSRVGANVQFSCEDNYVLQGSKSITCQRVTETLAAWSDHRPIC 407
Score = 30.8 bits (68), Expect = 2.7
Identities = 31/118 (26%), Positives = 44/118 (37%), Gaps = 26/118 (22%)
Query: 49 PRYKDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQS--- 105
PR DT S + +YG G + G+ C GY L GS+ L CQS
Sbjct: 1735 PRTSDTQCSSVPEPRYGRRI-----GSEFSA--GSIVRFECNPGYLLQGSTALHCQSVPN 1787
Query: 106 -NKRWSDKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCM 162
+W+D + P+ +P +G F R SPGY + C+
Sbjct: 1788 ALAQWNDTI-------PSCVVPCSGN--------FTQRRGTILSPGYPEPYGNNLNCI 1830
>gi|157419154 selectin P precursor [Homo sapiens]
Length = 830
Score = 84.3 bits (207), Expect = 2e-16
Identities = 78/315 (24%), Positives = 111/315 (35%), Gaps = 72/315 (22%)
Query: 67 VYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAM 125
V C P G + ++ C C +G L G+S+L C + W+ C+ C L
Sbjct: 459 VNCSHPFGAFRYQSV---CSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPCTPLLS 515
Query: 126 PANGGFKCVD---GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRI 182
P NG CV + + S C++ C GY+L G + C + W+ P C ++ P +
Sbjct: 516 PQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPEL 575
Query: 183 KCPSVKE------------------------RIAEPNKLTVRVSWETPEGRDTADGILTD 218
P ++ PN + S T GI +
Sbjct: 576 FAPEQGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIAS- 634
Query: 219 VILKGLP-PGSNFPEGDHKIQYTVYDRAENKGTCKFRV---------------------- 255
LP PG P Q T+Y R + GT F
Sbjct: 635 -----LPTPGVQCPALTTPGQGTMYCR-HHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRP 688
Query: 256 ---------KVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQGSPARVC 304
R +C +L+ + M CS+ N YG+ C F C+ G L GS C
Sbjct: 689 SGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTAC 748
Query: 305 QSNLAWSGTEPTCAA 319
Q N WS T PTC A
Sbjct: 749 QENGHWSTTVPTCQA 763
Score = 76.6 bits (187), Expect = 4e-14
Identities = 56/247 (22%), Positives = 94/247 (38%), Gaps = 27/247 (10%)
Query: 80 ALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTLAMPANGGFKC---VD 135
A G+ C CQ GY + G +L C + WS + C+ C L P +G C +
Sbjct: 345 AYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLR 404
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
+++ C + C+ G+ L+G V C + W+ C ++ + P+
Sbjct: 405 AFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQDLPVPN--------- 455
Query: 196 KLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRV 255
RV+ P G + + +GL + +V
Sbjct: 456 --EARVNCSHPFGAFRYQSVCSFTCNEGLL----------LVGASVLQCLATGNWNSVPP 503
Query: 256 KVRVKRCGKLNAPENGYMKCSSD--GDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGT 313
+ + C L +P+NG M C +Y +TC+F C GY L G C + W+ +
Sbjct: 504 ECQAIPCTPLLSPQNGTMTCVQPLGSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDS 563
Query: 314 EPTCAAM 320
P C A+
Sbjct: 564 PPMCEAI 570
Score = 72.8 bits (177), Expect = 6e-13
Identities = 59/271 (21%), Positives = 108/271 (39%), Gaps = 31/271 (11%)
Query: 57 CSPIKV-KYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-I 114
C P+K+ + G++ C + + C C++G+ L G ++ C ++ W+ +
Sbjct: 262 CPPLKIPERGNMTCLHSAKAFQHQS---SCSFSCEEGFALVGPEVVQCTASGVWTAPAPV 318
Query: 115 CKQKRCPTLAMPANGGFKCVD---GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRP 171
CK +C L P+ G CV + S C++ C PGY ++G + C+D+ WS
Sbjct: 319 CKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPL 378
Query: 172 ASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFP 231
+C + ++ P P+ + ++T A+G + G++
Sbjct: 379 PTCEAISCEPLESPVHGSMDCSPSLRAFQ--YDTNCSFRCAEGFML--------RGADIV 428
Query: 232 EGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSS--DGDNYGATCEFS 289
D+ Q+T C + +C L P + CS Y + C F+
Sbjct: 429 RCDNLGQWTA-----PAPVC------QALQCQDLPVPNEARVNCSHPFGAFRYQSVCSFT 477
Query: 290 CIGGYELQGSPARVCQSNLAWSGTEPTCAAM 320
C G L G+ C + W+ P C A+
Sbjct: 478 CNEGLLLVGASVLQCLATGNWNSVPPECQAI 508
Score = 65.1 bits (157), Expect = 1e-10
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 7/122 (5%)
Query: 69 CRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPA 127
C P G + + ++C C GY+++G S L C ++ W++K C +CP L +P
Sbjct: 213 CSHPLGNF---SFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPE 269
Query: 128 NGGFKCVDGA---YFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKC 184
G C+ A S C + C G+ L G V C + W+ C ++ ++
Sbjct: 270 RGNMTCLHSAKAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEA 329
Query: 185 PS 186
PS
Sbjct: 330 PS 331
Score = 64.7 bits (156), Expect = 2e-10
Identities = 50/209 (23%), Positives = 84/209 (40%), Gaps = 26/209 (12%)
Query: 118 KRCPTLAMPANGGFKC---VDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 174
+ C L +P + C + FNS+C ++C+ GY + G + C+ + W+ +P C
Sbjct: 198 RECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQC 257
Query: 175 VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGD 234
+ + P +K P E +T S + + + + + G
Sbjct: 258 LAAQCPPLKIP-------ERGNMTCLHSAKAFQHQSSCSFSCEEGFAL---------VGP 301
Query: 235 HKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKC--SSDGDNYGATCEFSCIG 292
+Q T A T V + +C L AP G M C YG++C+F C
Sbjct: 302 EVVQCT----ASGVWTAPAPV-CKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKFECQP 356
Query: 293 GYELQGSPARVCQSNLAWSGTEPTCAAMN 321
GY ++G C + WS PTC A++
Sbjct: 357 GYRVRGLDMLRCIDSGHWSAPLPTCEAIS 385
Score = 60.1 bits (144), Expect = 4e-09
Identities = 40/144 (27%), Positives = 66/144 (45%), Gaps = 22/144 (15%)
Query: 50 RYKDTP-WCSPIKV------KYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLI 102
R+ D+P C IK + G + C +G + +G+ C C G++L G + +
Sbjct: 559 RWTDSPPMCEAIKCPELFAPEQGSLDCSDTRGEFN---VGSTCHFSCDNGFKLEGPNNVE 615
Query: 103 CQSNKRWS-DKVICKQ--------KRCPTLAMPANGGFKCVD--GAY-FNSRCEYYCSPG 150
C ++ RWS CK +CP L P G C G + FN+ C + C+ G
Sbjct: 616 CTTSGRWSATPPTCKGIASLPTPGVQCPALTTPGQGTMYCRHHPGTFGFNTTCYFGCNAG 675
Query: 151 YTLKGERTVTCMDNKAWSGRPASC 174
+TL G+ T++C + W+ +C
Sbjct: 676 FTLIGDSTLSCRPSGQWTAVTPAC 699
Score = 52.4 bits (124), Expect = 9e-07
Identities = 30/114 (26%), Positives = 46/114 (40%), Gaps = 7/114 (6%)
Query: 65 GDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTL 123
G +YCR G + T C C G+ L G S L C+ + +W+ C+ +C L
Sbjct: 651 GTMYCRHHPGTF---GFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSEL 707
Query: 124 AMPANGGFKCVD---GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC 174
+ C + + S C ++C G L G C +N WS +C
Sbjct: 708 HVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTC 761
Score = 45.4 bits (106), Expect = 1e-04
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 259 VKRCGKLNAPENGYMKCSSDGDNYG--ATCEFSCIGGYELQGSPARVCQSNLAWSGTEPT 316
V+ CG+L P++ M CS N+ + C F C GY++ G C ++ W+ P
Sbjct: 197 VRECGELELPQHVLMNCSHPLGNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQ 256
Query: 317 CAA 319
C A
Sbjct: 257 CLA 259
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 76.3 bits (186), Expect = 6e-14
Identities = 79/270 (29%), Positives = 106/270 (39%), Gaps = 60/270 (22%)
Query: 62 VKYGDVYCRAPQGGYYKTALGTRCDIRCQKGY--ELHGSSLLICQSNKRWSDKV-ICKQK 118
++YGD Y +G CQ GY EL+GS + C N WS + C+
Sbjct: 3143 LRYGDDY-----------VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3191
Query: 119 RCPTLAMPANGGFKCVDGAYFN--SRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVD 176
CPT +NG ++G F+ Y CSPGY L +TC+ N WSG C+
Sbjct: 3192 TCPTPPQISNGR---LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP 3248
Query: 177 --MEPPRIKCPSVKERIAEPNKLTVRVSWETP---EGRDT----ADGILTDVILKGLPPG 227
P I +E + + V S P G T ADG + G
Sbjct: 3249 KFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWS---------G 3299
Query: 228 SNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCE 287
S+ H I+ T EN G V R G N ++ G G+ +
Sbjct: 3300 SS----PHCIEPT-QTSCENPG---------VPRHGSQN---------NTFGFQVGSVVQ 3336
Query: 288 FSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
F C G+ LQGS R C +L WSG +P C
Sbjct: 3337 FHCKKGHLLQGSTTRTCLPDLTWSGIQPEC 3366
Score = 75.9 bits (185), Expect = 7e-14
Identities = 73/282 (25%), Positives = 103/282 (36%), Gaps = 40/282 (14%)
Query: 74 GGYYKTALGTRCDIR--CQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGG 130
G ++ T+ +R C GY LHGS C +N W+ + CK +C ANG
Sbjct: 3025 GSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGK 3084
Query: 131 FKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKER 190
+DG F+S Y C GY L G C N WSG +C + P+ R
Sbjct: 3085 VFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLR 3144
Query: 191 IAEPNKLTVRVSWETPEGRD-----------TADGILTDV--------------ILKGLP 225
+ + VS+ G T +G + V I G
Sbjct: 3145 YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRL 3204
Query: 226 PGSNFPEG---------DHKIQYTVYDRAENKGTCKFRV-KVRVKRCGKLNAPENGYMKC 275
G+NF G +++ + GT V + K CG P G K
Sbjct: 3205 EGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQG--KR 3262
Query: 276 SSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Y + FSC + L GS R+CQ++ WSG+ P C
Sbjct: 3263 EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHC 3304
Score = 73.9 bits (180), Expect = 3e-13
Identities = 64/239 (26%), Positives = 90/239 (37%), Gaps = 39/239 (16%)
Query: 88 RCQKGYELHGSSLLICQSNKRWSDK------VICKQKRCPTLAMPANGGFKCVDGAYFNS 141
+C G+ L GSS+ ICQ + WS + V C P + GF FN
Sbjct: 2802 QCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN------FND 2855
Query: 142 RCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC--VDMEPPRIKCPSVKERIAEPNKLTV 199
+ C+ GY ++G C N+ WS P C V+ P I S +E E T
Sbjct: 2856 VVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY 2915
Query: 200 RVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRV 259
V+ PG F G +V N K + +
Sbjct: 2916 GT-----------------VVFYDCNPG-YFLFGS-----SVLICQPNGQWDKPLPECIM 2952
Query: 260 KRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCA 318
CG P N + S + +G+T +SC G L G +R CQ N WSG++P C+
Sbjct: 2953 IDCGHPGVPPNAVL--SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCS 3009
Score = 73.2 bits (178), Expect = 5e-13
Identities = 73/278 (26%), Positives = 109/278 (39%), Gaps = 43/278 (15%)
Query: 61 KVKYGDVYCRAPQG---GYYKTALGTRCDI----RCQKGYELHGSSLLICQSNK----RW 109
+++Y YC P+ GY + G + + C +G+ L G S +C+ + W
Sbjct: 2521 RIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW 2580
Query: 110 SDKV-ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGER--TVTCMDNKA 166
V C+ C P NGG D +R Y+C+ GY L + T C +
Sbjct: 2581 DAPVPACQAISCGIPKAPTNGGILTTD-YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT 2639
Query: 167 WS--GRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGL 224
WS + CV + CPS+ I E + W G T V+
Sbjct: 2640 WSNHNKTPRCV-----VVTCPSINSFILEHGR------WRIVNGSHYE--YKTKVVFSCD 2686
Query: 225 PPGSNFPEGDHKIQYTVYDRAENKGTCKFRVK---VRVKRCGKLNAPENGYMKCSSDGDN 281
P G H + + N GT +R + ++ CG+L P NG +
Sbjct: 2687 P-------GYHGLGPASIECLPN-GTWSWRNERPYCQIISCGELPTPPNG--NKIGTQTS 2736
Query: 282 YGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAA 319
YG+T F+C G+ L GS R C S+ WS +E C A
Sbjct: 2737 YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA 2774
Score = 71.6 bits (174), Expect = 1e-12
Identities = 72/312 (23%), Positives = 115/312 (36%), Gaps = 52/312 (16%)
Query: 55 PWCSPIKVKY--GDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDK 112
P C P+ + +Y R G+ + T C GY + G + CQ+N++WS
Sbjct: 2828 PSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT---FSCNIGYLMQGPTKAQCQANRQWSHP 2884
Query: 113 V-ICKQKRCPTLAMPANGG--FKCVDGAYFNSRCEYY-CSPGYTLKGERTVTCMDNKAWS 168
+CK C +PAN K G + +Y C+PGY L G + C N W
Sbjct: 2885 PPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWD 2944
Query: 169 GRPASCVDME------PP---------------RIKCPSVKERIAEPNK---LTVRVSWE 204
C+ ++ PP C + + + ++ L S
Sbjct: 2945 KPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGS 3004
Query: 205 TPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAE--------NKGTCKF--- 253
P A G D G P + E + + + TV + + TC
Sbjct: 3005 QPHCSGDATGTCGD---PGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGS 3061
Query: 254 ----RVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA 309
+ + + +CG NG + DG + ++ +SC+ GY L G R C +N
Sbjct: 3062 WTGRQPECKAVQCGNPGTTANGKV-FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 3120
Query: 310 WSGTEPTCAAMN 321
WSGT P C ++
Sbjct: 3121 WSGTLPNCTIIS 3132
Score = 68.2 bits (165), Expect = 2e-11
Identities = 77/313 (24%), Positives = 115/313 (36%), Gaps = 77/313 (24%)
Query: 70 RAPQGGYYKTA---LGTRCDIRCQKGYELHGSSLL--ICQSNKRWSDKVICKQKRCPTLA 124
+AP G T +GTR C GY L L +CQS+ WS+ K RC +
Sbjct: 2596 KAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHN--KTPRCVVVT 2653
Query: 125 MPA-------NGGFKCVDGAYFNSRCE--YYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
P+ +G ++ V+G+++ + + + C PGY G ++ C+ N WS R
Sbjct: 2654 CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWR----- 2708
Query: 176 DMEPPRIKCPSVKERIAEP--NKLTVRVS----------------------------WET 205
E P + S E P NK+ + S W
Sbjct: 2709 -NERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSE 2767
Query: 206 PEGRDTADGI-LTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKR--- 261
E R A + ++I+ G G N+ D + N G VR+ +
Sbjct: 2768 SETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQC------NPGFRLIGSSVRICQQDH 2821
Query: 262 -------------CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNL 308
CG +P Y + S +G N+ FSC GY +QG CQ+N
Sbjct: 2822 NWSGQLPSCVPVSCGHPGSPI--YGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR 2879
Query: 309 AWSGTEPTCAAMN 321
WS P C +N
Sbjct: 2880 QWSHPPPMCKVVN 2892
Score = 59.7 bits (143), Expect = 5e-09
Identities = 72/278 (25%), Positives = 89/278 (32%), Gaps = 40/278 (14%)
Query: 52 KDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWS- 110
K P C I + V A G K G+ C L G S CQ N WS
Sbjct: 2945 KPLPECIMIDCGHPGVPPNAVLSGE-KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSG 3003
Query: 111 DKVICKQKRCPTLAMPANGGFKCVDGAYF--NSRCEYYCSPGYTLKGERTVTCMDNKAWS 168
+ C T P G + F S Y C GY L G TC+ N +W+
Sbjct: 3004 SQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWT 3063
Query: 169 GRPASC--VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPP 226
GR C V P RI + + V + EG + + G
Sbjct: 3064 GRQPECKAVQCGNPGTTANGKVFRI-DGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWS 3122
Query: 227 GSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNY--GA 284
G+ + CG P NG GD+Y G
Sbjct: 3123 GT-------------------------LPNCTIISCGDPGIPANGLRY----GDDYVVGQ 3153
Query: 285 TCEFSCIGGY--ELQGSPARVCQSNLAWSGTEPTCAAM 320
+ C GY EL GS R C N WSG PTC A+
Sbjct: 3154 NVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3191
Score = 59.3 bits (142), Expect = 7e-09
Identities = 68/283 (24%), Positives = 102/283 (36%), Gaps = 34/283 (12%)
Query: 78 KTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDG 136
+T+ G+ C G+ L GS++ C S+ WS+ + C C + NG + +
Sbjct: 2734 QTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNG--QVIGE 2791
Query: 137 AY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
Y + Y C+PG+ L G C + WSG+ SCV + P
Sbjct: 2792 NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIY-------- 2843
Query: 196 KLTVRVSWETPEGRDTADGI-LTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFR 254
GR + +G DV+ G +G K Q N+
Sbjct: 2844 ------------GRTSGNGFNFNDVVTFSCNIGY-LMQGPTKAQCQA-----NRQWSHPP 2885
Query: 255 VKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQGSPARVCQSNLAWSG 312
+V C P N + + N YG + C GY L GS +CQ N W
Sbjct: 2886 PMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDK 2945
Query: 313 TEPTCAAMNV-NVGVRTAAALLDQFYEKRRLLIVSTPTARNLL 354
P C ++ + GV A L + Y + S R+LL
Sbjct: 2946 PLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLL 2988
Score = 56.6 bits (135), Expect = 5e-08
Identities = 60/243 (24%), Positives = 89/243 (36%), Gaps = 45/243 (18%)
Query: 89 CQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYC 147
C GYEL ++L C N WS +V C K C +PA G + Y S + C
Sbjct: 3219 CSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIY-QSEVSFSC 3277
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKC--PSVKERIAEPNKLTVRVS--- 202
+ + L G T C + WSG C+ EP + C P V ++ N +V
Sbjct: 3278 NFPFILVGSSTRICQADGTWSGSSPHCI--EPTQTSCENPGVPRHGSQNNTFGFQVGSVV 3335
Query: 203 -WETPEGR----DTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKV 257
+ +G T L D+ G+ P P
Sbjct: 3336 QFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC-IPHS------------------------ 3370
Query: 258 RVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPA-RVCQSNLAWSGTEPT 316
C + P + + D ++G T ++C G+ L G RVC+S+ W+G P
Sbjct: 3371 ----CKQPETPAHANV-VGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPI 3425
Query: 317 CAA 319
C A
Sbjct: 3426 CEA 3428
Score = 55.1 bits (131), Expect = 1e-07
Identities = 66/243 (27%), Positives = 92/243 (37%), Gaps = 49/243 (20%)
Query: 89 CQKGYELHGSSLLICQSNKR--WSDKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYY 146
C GY LHGSSLL C + +R W + P+ G FK
Sbjct: 1341 CNPGYTLHGSSLLKCMTGERRAWDYPL-------PSCIAECGGRFK-------GESSGRI 1386
Query: 147 CSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETP 206
SPGY + + CM W ++++P I E + +RV W+ P
Sbjct: 1387 LSPGYPFPYDNNLRCM----W------MIEVDPGNIVSLQFLAFDTEASHDILRV-WDGP 1435
Query: 207 EGRDTADGILTDVILKGLPPGSNFPEGDHK------IQY-TVYDRAENKGTCKFRVKVRV 259
D++LK + GS PEG H IQ+ T + +++ +F V
Sbjct: 1436 PE--------NDMLLKEI-SGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV-A 1485
Query: 260 KRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC---QSNLAWSGTEPT 316
C P NG + DG G T F C GYELQG C ++ W + P
Sbjct: 1486 TACRDPGVPMNGTR--NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPV 1543
Query: 317 CAA 319
C A
Sbjct: 1544 CIA 1546
Score = 40.8 bits (94), Expect = 0.003
Identities = 28/105 (26%), Positives = 42/105 (40%), Gaps = 4/105 (3%)
Query: 73 QGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGF 131
Q + +G+ C+KG+ L GS+ C + WS + C C PA+
Sbjct: 3323 QNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV 3382
Query: 132 KCVDGAYFNSRCEYYCSPGYTLKG--ERTVTCMDNKAWSGRPASC 174
+D Y C PG+ L G E V C + W+G+ C
Sbjct: 3383 VGMDLPSHGYTLIYTCQPGFFLAGGTEHRV-CRSDNTWTGKVPIC 3426
Score = 39.3 bits (90), Expect = 0.008
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 5/75 (6%)
Query: 246 ENKGTCKFRV---KVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPAR 302
E+ G+ F+V ++ + CG P G + DG + F C G+EL G +
Sbjct: 605 ESVGSVGFKVNYKEIEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSI 662
Query: 303 VCQSNLAWSGTEPTC 317
VCQ N WS P C
Sbjct: 663 VCQENNQWSANIPIC 677
Score = 38.9 bits (89), Expect = 0.010
Identities = 57/239 (23%), Positives = 86/239 (35%), Gaps = 44/239 (18%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYT-LKGERTVTC--MDNKA-WSGRPASC- 174
CP +P N + D S C G+ +G T+TC MD K WSG C
Sbjct: 794 CPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG 852
Query: 175 ------------VDMEP-------PRIKCPSVKERIAEPNKLTVRVSWETPEGR------ 209
V + P + C V E AEP ++++++E +
Sbjct: 853 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIE--AEPGH-SIKITFERFQTELNYDVL 909
Query: 210 DTADGILTDVILKGLPPGSNFPE---GDHKIQYTVYDRAENKGTCKFR-----VKVRVKR 261
+ DG L G G+ P+ Y ++ ++ F+ V V
Sbjct: 910 EVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 969
Query: 262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAM 320
C P +G + + G+T FSC GY L +C+ N WS PTC A+
Sbjct: 970 CLDPGIPVHG--RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 1026
Score = 38.5 bits (88), Expect = 0.013
Identities = 56/251 (22%), Positives = 88/251 (35%), Gaps = 42/251 (16%)
Query: 77 YKTALGTRCDIRCQKGYELHGSSLLICQSNKR--WSDKVICKQKRCPTLAMPANGGFKCV 134
+ +G C GY L G+S +IC R WS + RC +C
Sbjct: 1156 FNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPL----PRCVA---------EC- 1201
Query: 135 DGAYFNSRCEYYCSPGYTLKGERTVTCMDN-KAWSGRPASCVDMEPPRIKCPSVKERIAE 193
GA + SP Y L E C+ + + +G+ I + +A+
Sbjct: 1202 -GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKG----------INISARTFHLAQ 1250
Query: 194 PNKLTVRVSWETPEGRDTAD---GILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGT 250
+ L + +G+D G T ++GL S +++ ++G
Sbjct: 1251 GDVLKIY------DGKDKTTHLLGAFTGASMRGLTLSST--SNQLWLEFNSDTEGTDEGF 1302
Query: 251 CKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQS--NL 308
+ C P+ GY K S G G+T + C GY L GS C +
Sbjct: 1303 QLVYTSFELSHCEDPGIPQFGY-KISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERR 1361
Query: 309 AWSGTEPTCAA 319
AW P+C A
Sbjct: 1362 AWDYPLPSCIA 1372
Score = 38.1 bits (87), Expect = 0.017
Identities = 45/218 (20%), Positives = 79/218 (36%), Gaps = 42/218 (19%)
Query: 145 YYCSPGYTLKGERTVTCM--DNKAWSGRPASCVDMEP---------------------PR 181
Y C PG+TL G +TC + G P C + P P
Sbjct: 2381 YQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPN 2440
Query: 182 IKCPSVKERIAEPNKLTVRVSWETPEGR----DTADG--ILTDVILK---GLPPGSNFPE 232
++ + + + +T+ V + E DG I + V++ N
Sbjct: 2441 LQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITS 2500
Query: 233 GDHKI--QYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSC 290
H++ Q++ KG FR++ C +P +GY+ S G + ++C
Sbjct: 2501 NGHEVFLQWSADHGNNKKG---FRIRYIAFYCSTPESPPHGYI-ISQTGGQLNSVVRWAC 2556
Query: 291 IGGYELQGSPARVCQSNL----AWSGTEPTCAAMNVNV 324
G+ L G + VC+ + AW P C A++ +
Sbjct: 2557 DRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGI 2594
Score = 36.6 bits (83), Expect = 0.050
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 14/92 (15%)
Query: 230 FPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFS 289
FP D+ ++++ N+G +K C PENG K + G+T +FS
Sbjct: 422 FPGKDNSNKFSIL----NEGG----IKTASNLCPDPGEPENG--KRIGSDFSLGSTVQFS 471
Query: 290 CIGGYELQGSPARVCQS----NLAWSGTEPTC 317
C Y LQG+ + CQ AWS P C
Sbjct: 472 CDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 503
Score = 32.7 bits (73), Expect = 0.72
Identities = 13/28 (46%), Positives = 18/28 (64%), Gaps = 1/28 (3%)
Query: 89 CQKGYELHGSSLLICQSNKRWSDKV-IC 115
CQ G+EL G ++CQ N +WS + IC
Sbjct: 650 CQFGFELIGEKSIVCQENNQWSANIPIC 677
Score = 32.3 bits (72), Expect = 0.94
Identities = 18/70 (25%), Positives = 27/70 (38%), Gaps = 6/70 (8%)
Query: 106 NKRWSDKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNK 165
N + +K C P + GF D F C G+ L GE+++ C +N
Sbjct: 615 NYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFE------CQFGFELIGEKSIVCQENN 668
Query: 166 AWSGRPASCV 175
WS C+
Sbjct: 669 QWSANIPICI 678
Score = 32.3 bits (72), Expect = 0.94
Identities = 54/254 (21%), Positives = 83/254 (32%), Gaps = 53/254 (20%)
Query: 80 ALGTRCDIRCQKGYELHGSSLLICQ----SNKRWSDKVICKQKRCPTLAMPANGGFKCVD 135
A+G+ C GY LHGS + C+ S +W+D + PT +P
Sbjct: 1855 AVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSL-------PTCIVPC-------- 1899
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
G R SPGY + + C+ W +I P +
Sbjct: 1900 GGILTKRKGTILSPGYPEPYDNNLNCV----W-------------KITVPEGAGIQVQVV 1942
Query: 196 KLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK---GTCK 252
+W++ D DG + G G+ P + +Y ++
Sbjct: 1943 SFATEHNWDS---LDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAG 1999
Query: 253 FRVK---VRVKRCGKLNAPENGYMKCSSDGDNY--GATCEFSCIGGYELQGSPARVCQSN 307
F ++ + + C + P +G GD Y G F C GY LQG C
Sbjct: 2000 FHLEYTAIGLDSCPEPQTPSSGI----KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPG 2055
Query: 308 --LAWSGTEPTCAA 319
W+ P C A
Sbjct: 2056 PVRRWNYPIPICLA 2069
Score = 31.6 bits (70), Expect = 1.6
Identities = 52/217 (23%), Positives = 77/217 (35%), Gaps = 42/217 (19%)
Query: 141 SRCEYYCSPGYTLKGERTVTCM----DNKAWSGRPASC-------------VDMEPPRIK 183
S YYC GY L+G T+TC+ W+ SC + P K
Sbjct: 1681 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPK 1740
Query: 184 CPSVKER----IAEPNKLTVRVSW-----------ETPEGRDTADGILTDVILKGLPPGS 228
SV IA P + V + E +G +L+ L G G
Sbjct: 1741 NYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSS--LSGSHSGE 1798
Query: 229 NFP--EGDH-KIQYTVYDRAENKG-TCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGA 284
+ P G+ I++T KG ++ R + PE + + + G+
Sbjct: 1799 SLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGS 1858
Query: 285 TCEFSCIGGYELQGSPARVCQ----SNLAWSGTEPTC 317
+ F C GY L GS A C+ S W+ + PTC
Sbjct: 1859 SVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1895
Score = 30.8 bits (68), Expect = 2.7
Identities = 23/100 (23%), Positives = 37/100 (37%), Gaps = 6/100 (6%)
Query: 224 LPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYG 283
LPP + ++ T G + +++ CG P G + + + G
Sbjct: 100 LPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRF--DVG 157
Query: 284 ATCEFSCIGGYELQGSPARVCQSN----LAWSGTEPTCAA 319
+SC+ GY L G P C +N +W P C A
Sbjct: 158 DKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 197
Score = 30.4 bits (67), Expect = 3.6
Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 5/57 (8%)
Query: 80 ALGTRCDIRCQKGYELHGSSLLICQSNKR----WSD-KVICKQKRCPTLAMPANGGF 131
+LG+ C + Y L G+ + CQ WSD + +CK K C + +G F
Sbjct: 463 SLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTF 519
Score = 30.0 bits (66), Expect = 4.6
Identities = 47/235 (20%), Positives = 77/235 (32%), Gaps = 38/235 (16%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDN--KAWSGRPASCVDM 177
CP P++G K D + C GY+L+G +TCM + W+ C+
Sbjct: 2012 CPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2070
Query: 178 --------------------EPPRIKCP---------SVKERIAEPNKLTVRVSWETPEG 208
P + C V + + T+ E G
Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSG 2130
Query: 209 RDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK-GTCKFRVKVRVKRCGKLNA 267
++ + +P S F Y D ++NK G +++ C
Sbjct: 2131 SSETSTVIGRLSGPQIP-SSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRP 2189
Query: 268 PENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA--WSGTEPTCAAM 320
NG++ + G T F C GY L G+ A C ++ W+ P C A+
Sbjct: 2190 FRNGFV--IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2242
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 76.3 bits (186), Expect = 6e-14
Identities = 79/270 (29%), Positives = 106/270 (39%), Gaps = 60/270 (22%)
Query: 62 VKYGDVYCRAPQGGYYKTALGTRCDIRCQKGY--ELHGSSLLICQSNKRWSDKV-ICKQK 118
++YGD Y +G CQ GY EL+GS + C N WS + C+
Sbjct: 3014 LRYGDDY-----------VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3062
Query: 119 RCPTLAMPANGGFKCVDGAYFN--SRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVD 176
CPT +NG ++G F+ Y CSPGY L +TC+ N WSG C+
Sbjct: 3063 TCPTPPQISNGR---LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP 3119
Query: 177 --MEPPRIKCPSVKERIAEPNKLTVRVSWETP---EGRDT----ADGILTDVILKGLPPG 227
P I +E + + V S P G T ADG + G
Sbjct: 3120 KFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWS---------G 3170
Query: 228 SNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCE 287
S+ H I+ T EN G V R G N ++ G G+ +
Sbjct: 3171 SS----PHCIEPT-QTSCENPG---------VPRHGSQN---------NTFGFQVGSVVQ 3207
Query: 288 FSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
F C G+ LQGS R C +L WSG +P C
Sbjct: 3208 FHCKKGHLLQGSTTRTCLPDLTWSGIQPEC 3237
Score = 75.9 bits (185), Expect = 7e-14
Identities = 73/282 (25%), Positives = 103/282 (36%), Gaps = 40/282 (14%)
Query: 74 GGYYKTALGTRCDIR--CQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGG 130
G ++ T+ +R C GY LHGS C +N W+ + CK +C ANG
Sbjct: 2896 GSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGK 2955
Query: 131 FKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKER 190
+DG F+S Y C GY L G C N WSG +C + P+ R
Sbjct: 2956 VFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLR 3015
Query: 191 IAEPNKLTVRVSWETPEGRD-----------TADGILTDV--------------ILKGLP 225
+ + VS+ G T +G + V I G
Sbjct: 3016 YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRL 3075
Query: 226 PGSNFPEG---------DHKIQYTVYDRAENKGTCKFRV-KVRVKRCGKLNAPENGYMKC 275
G+NF G +++ + GT V + K CG P G K
Sbjct: 3076 EGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQG--KR 3133
Query: 276 SSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Y + FSC + L GS R+CQ++ WSG+ P C
Sbjct: 3134 EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHC 3175
Score = 73.9 bits (180), Expect = 3e-13
Identities = 64/239 (26%), Positives = 90/239 (37%), Gaps = 39/239 (16%)
Query: 88 RCQKGYELHGSSLLICQSNKRWSDK------VICKQKRCPTLAMPANGGFKCVDGAYFNS 141
+C G+ L GSS+ ICQ + WS + V C P + GF FN
Sbjct: 2673 QCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN------FND 2726
Query: 142 RCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC--VDMEPPRIKCPSVKERIAEPNKLTV 199
+ C+ GY ++G C N+ WS P C V+ P I S +E E T
Sbjct: 2727 VVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY 2786
Query: 200 RVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRV 259
V+ PG F G +V N K + +
Sbjct: 2787 GT-----------------VVFYDCNPG-YFLFGS-----SVLICQPNGQWDKPLPECIM 2823
Query: 260 KRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCA 318
CG P N + S + +G+T +SC G L G +R CQ N WSG++P C+
Sbjct: 2824 IDCGHPGVPPNAVL--SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCS 2880
Score = 71.6 bits (174), Expect = 1e-12
Identities = 72/312 (23%), Positives = 115/312 (36%), Gaps = 52/312 (16%)
Query: 55 PWCSPIKVKY--GDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDK 112
P C P+ + +Y R G+ + T C GY + G + CQ+N++WS
Sbjct: 2699 PSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT---FSCNIGYLMQGPTKAQCQANRQWSHP 2755
Query: 113 V-ICKQKRCPTLAMPANGG--FKCVDGAYFNSRCEYY-CSPGYTLKGERTVTCMDNKAWS 168
+CK C +PAN K G + +Y C+PGY L G + C N W
Sbjct: 2756 PPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWD 2815
Query: 169 GRPASCVDME------PP---------------RIKCPSVKERIAEPNK---LTVRVSWE 204
C+ ++ PP C + + + ++ L S
Sbjct: 2816 KPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGS 2875
Query: 205 TPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAE--------NKGTCKF--- 253
P A G D G P + E + + + TV + + TC
Sbjct: 2876 QPHCSGDATGTCGD---PGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGS 2932
Query: 254 ----RVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA 309
+ + + +CG NG + DG + ++ +SC+ GY L G R C +N
Sbjct: 2933 WTGRQPECKAVQCGNPGTTANGKV-FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 2991
Query: 310 WSGTEPTCAAMN 321
WSGT P C ++
Sbjct: 2992 WSGTLPNCTIIS 3003
Score = 63.9 bits (154), Expect = 3e-10
Identities = 73/316 (23%), Positives = 110/316 (34%), Gaps = 64/316 (20%)
Query: 61 KVKYGDVYCRAPQG---GYYKTALGTRCDI----RCQKGYELHGSSLLICQSNK----RW 109
+++Y YC P+ GY + G + + C +G+ L G S +C+ + W
Sbjct: 2457 RIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW 2516
Query: 110 SDKV-ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGER--TVTCMDNKA 166
V C+ C P NGG D +R Y+C+ GY L + T C +
Sbjct: 2517 DAPVPACQAISCGIPKAPTNGGILTTD-YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT 2575
Query: 167 WS--GRPASCVDMEPPRIKCPSVKERIAEPNKL-----------------TVRVS----- 202
WS + CV + + P +I VR
Sbjct: 2576 WSNHNKTPRCVVISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGL 2635
Query: 203 WETPEGRDTADGI-LTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKR 261
W E R A + ++I+ G G N+ D + N G VR+ +
Sbjct: 2636 WSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQC------NPGFRLIGSSVRICQ 2689
Query: 262 ----------------CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQ 305
CG +P Y + S +G N+ FSC GY +QG CQ
Sbjct: 2690 QDHNWSGQLPSCVPVSCGHPGSPI--YGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQ 2747
Query: 306 SNLAWSGTEPTCAAMN 321
+N WS P C +N
Sbjct: 2748 ANRQWSHPPPMCKVVN 2763
Score = 59.7 bits (143), Expect = 5e-09
Identities = 72/278 (25%), Positives = 89/278 (32%), Gaps = 40/278 (14%)
Query: 52 KDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWS- 110
K P C I + V A G K G+ C L G S CQ N WS
Sbjct: 2816 KPLPECIMIDCGHPGVPPNAVLSGE-KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSG 2874
Query: 111 DKVICKQKRCPTLAMPANGGFKCVDGAYF--NSRCEYYCSPGYTLKGERTVTCMDNKAWS 168
+ C T P G + F S Y C GY L G TC+ N +W+
Sbjct: 2875 SQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWT 2934
Query: 169 GRPASC--VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPP 226
GR C V P RI + + V + EG + + G
Sbjct: 2935 GRQPECKAVQCGNPGTTANGKVFRI-DGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWS 2993
Query: 227 GSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNY--GA 284
G+ + CG P NG GD+Y G
Sbjct: 2994 GT-------------------------LPNCTIISCGDPGIPANGLRY----GDDYVVGQ 3024
Query: 285 TCEFSCIGGY--ELQGSPARVCQSNLAWSGTEPTCAAM 320
+ C GY EL GS R C N WSG PTC A+
Sbjct: 3025 NVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3062
Score = 59.3 bits (142), Expect = 7e-09
Identities = 69/283 (24%), Positives = 103/283 (36%), Gaps = 34/283 (12%)
Query: 78 KTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDG 136
+T+ G+ C G+ L GS++ C S+ WS+ + C C + NG + +
Sbjct: 2605 QTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNG--QVIGE 2662
Query: 137 AY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
Y + Y C+PG+ L G C + WSG+ SCV + C I
Sbjct: 2663 NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVP-----VSCGHPGSPI---- 2713
Query: 196 KLTVRVSWETPEGRDTADGI-LTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFR 254
GR + +G DV+ G +G K Q N+
Sbjct: 2714 -----------YGRTSGNGFNFNDVVTFSCNIG-YLMQGPTKAQCQA-----NRQWSHPP 2756
Query: 255 VKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQGSPARVCQSNLAWSG 312
+V C P N + + N YG + C GY L GS +CQ N W
Sbjct: 2757 PMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDK 2816
Query: 313 TEPTCAAMNV-NVGVRTAAALLDQFYEKRRLLIVSTPTARNLL 354
P C ++ + GV A L + Y + S R+LL
Sbjct: 2817 PLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLL 2859
Score = 56.6 bits (135), Expect = 5e-08
Identities = 60/243 (24%), Positives = 89/243 (36%), Gaps = 45/243 (18%)
Query: 89 CQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYC 147
C GYEL ++L C N WS +V C K C +PA G + Y S + C
Sbjct: 3090 CSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIY-QSEVSFSC 3148
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKC--PSVKERIAEPNKLTVRVS--- 202
+ + L G T C + WSG C+ EP + C P V ++ N +V
Sbjct: 3149 NFPFILVGSSTRICQADGTWSGSSPHCI--EPTQTSCENPGVPRHGSQNNTFGFQVGSVV 3206
Query: 203 -WETPEGR----DTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKV 257
+ +G T L D+ G+ P P
Sbjct: 3207 QFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC-IPHS------------------------ 3241
Query: 258 RVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPA-RVCQSNLAWSGTEPT 316
C + P + + D ++G T ++C G+ L G RVC+S+ W+G P
Sbjct: 3242 ----CKQPETPAHANV-VGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPI 3296
Query: 317 CAA 319
C A
Sbjct: 3297 CEA 3299
Score = 55.1 bits (131), Expect = 1e-07
Identities = 66/243 (27%), Positives = 92/243 (37%), Gaps = 49/243 (20%)
Query: 89 CQKGYELHGSSLLICQSNKR--WSDKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYY 146
C GY LHGSSLL C + +R W + P+ G FK
Sbjct: 1277 CNPGYTLHGSSLLKCMTGERRAWDYPL-------PSCIAECGGRFK-------GESSGRI 1322
Query: 147 CSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETP 206
SPGY + + CM W ++++P I E + +RV W+ P
Sbjct: 1323 LSPGYPFPYDNNLRCM----W------MIEVDPGNIVSLQFLAFDTEASHDILRV-WDGP 1371
Query: 207 EGRDTADGILTDVILKGLPPGSNFPEGDHK------IQY-TVYDRAENKGTCKFRVKVRV 259
D++LK + GS PEG H IQ+ T + +++ +F V
Sbjct: 1372 PE--------NDMLLKEI-SGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV-A 1421
Query: 260 KRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC---QSNLAWSGTEPT 316
C P NG + DG G T F C GYELQG C ++ W + P
Sbjct: 1422 TACRDPGVPMNGTR--NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPV 1479
Query: 317 CAA 319
C A
Sbjct: 1480 CIA 1482
Score = 40.8 bits (94), Expect = 0.003
Identities = 28/105 (26%), Positives = 42/105 (40%), Gaps = 4/105 (3%)
Query: 73 QGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGF 131
Q + +G+ C+KG+ L GS+ C + WS + C C PA+
Sbjct: 3194 QNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV 3253
Query: 132 KCVDGAYFNSRCEYYCSPGYTLKG--ERTVTCMDNKAWSGRPASC 174
+D Y C PG+ L G E V C + W+G+ C
Sbjct: 3254 VGMDLPSHGYTLIYTCQPGFFLAGGTEHRV-CRSDNTWTGKVPIC 3297
Score = 39.3 bits (90), Expect = 0.008
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 5/75 (6%)
Query: 246 ENKGTCKFRV---KVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPAR 302
E+ G+ F+V ++ + CG P G + DG + F C G+EL G +
Sbjct: 541 ESVGSVGFKVNYKEIEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSI 598
Query: 303 VCQSNLAWSGTEPTC 317
VCQ N WS P C
Sbjct: 599 VCQENNQWSANIPIC 613
Score = 38.9 bits (89), Expect = 0.010
Identities = 57/239 (23%), Positives = 86/239 (35%), Gaps = 44/239 (18%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYT-LKGERTVTC--MDNKA-WSGRPASC- 174
CP +P N + D S C G+ +G T+TC MD K WSG C
Sbjct: 730 CPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG 788
Query: 175 ------------VDMEP-------PRIKCPSVKERIAEPNKLTVRVSWETPEGR------ 209
V + P + C V E AEP ++++++E +
Sbjct: 789 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIE--AEPGH-SIKITFERFQTELNYDVL 845
Query: 210 DTADGILTDVILKGLPPGSNFPE---GDHKIQYTVYDRAENKGTCKFR-----VKVRVKR 261
+ DG L G G+ P+ Y ++ ++ F+ V V
Sbjct: 846 EVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 905
Query: 262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAM 320
C P +G + + G+T FSC GY L +C+ N WS PTC A+
Sbjct: 906 CLDPGIPVHG--RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 962
Score = 38.5 bits (88), Expect = 0.013
Identities = 56/251 (22%), Positives = 88/251 (35%), Gaps = 42/251 (16%)
Query: 77 YKTALGTRCDIRCQKGYELHGSSLLICQSNKR--WSDKVICKQKRCPTLAMPANGGFKCV 134
+ +G C GY L G+S +IC R WS + RC +C
Sbjct: 1092 FNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPL----PRCVA---------EC- 1137
Query: 135 DGAYFNSRCEYYCSPGYTLKGERTVTCMDN-KAWSGRPASCVDMEPPRIKCPSVKERIAE 193
GA + SP Y L E C+ + + +G+ I + +A+
Sbjct: 1138 -GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKG----------INISARTFHLAQ 1186
Query: 194 PNKLTVRVSWETPEGRDTAD---GILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGT 250
+ L + +G+D G T ++GL S +++ ++G
Sbjct: 1187 GDVLKIY------DGKDKTTHLLGAFTGASMRGLTLSST--SNQLWLEFNSDTEGTDEGF 1238
Query: 251 CKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQS--NL 308
+ C P+ GY K S G G+T + C GY L GS C +
Sbjct: 1239 QLVYTSFELSHCEDPGIPQFGY-KISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERR 1297
Query: 309 AWSGTEPTCAA 319
AW P+C A
Sbjct: 1298 AWDYPLPSCIA 1308
Score = 36.6 bits (83), Expect = 0.050
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 14/92 (15%)
Query: 230 FPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFS 289
FP D+ ++++ N+G +K C PENG K + G+T +FS
Sbjct: 358 FPGKDNSNKFSIL----NEGG----IKTASNLCPDPGEPENG--KRIGSDFSLGSTVQFS 407
Query: 290 CIGGYELQGSPARVCQS----NLAWSGTEPTC 317
C Y LQG+ + CQ AWS P C
Sbjct: 408 CDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 439
Score = 32.7 bits (73), Expect = 0.72
Identities = 13/28 (46%), Positives = 18/28 (64%), Gaps = 1/28 (3%)
Query: 89 CQKGYELHGSSLLICQSNKRWSDKV-IC 115
CQ G+EL G ++CQ N +WS + IC
Sbjct: 586 CQFGFELIGEKSIVCQENNQWSANIPIC 613
Score = 32.3 bits (72), Expect = 0.94
Identities = 18/70 (25%), Positives = 27/70 (38%), Gaps = 6/70 (8%)
Query: 106 NKRWSDKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNK 165
N + +K C P + GF D F C G+ L GE+++ C +N
Sbjct: 551 NYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFE------CQFGFELIGEKSIVCQENN 604
Query: 166 AWSGRPASCV 175
WS C+
Sbjct: 605 QWSANIPICI 614
Score = 32.3 bits (72), Expect = 0.94
Identities = 54/254 (21%), Positives = 83/254 (32%), Gaps = 53/254 (20%)
Query: 80 ALGTRCDIRCQKGYELHGSSLLICQ----SNKRWSDKVICKQKRCPTLAMPANGGFKCVD 135
A+G+ C GY LHGS + C+ S +W+D + PT +P
Sbjct: 1791 AVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSL-------PTCIVPC-------- 1835
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
G R SPGY + + C+ W +I P +
Sbjct: 1836 GGILTKRKGTILSPGYPEPYDNNLNCV----W-------------KITVPEGAGIQVQVV 1878
Query: 196 KLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK---GTCK 252
+W++ D DG + G G+ P + +Y ++
Sbjct: 1879 SFATEHNWDS---LDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAG 1935
Query: 253 FRVK---VRVKRCGKLNAPENGYMKCSSDGDNY--GATCEFSCIGGYELQGSPARVCQSN 307
F ++ + + C + P +G GD Y G F C GY LQG C
Sbjct: 1936 FHLEYTAIGLDSCPEPQTPSSGI----KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPG 1991
Query: 308 --LAWSGTEPTCAA 319
W+ P C A
Sbjct: 1992 PVRRWNYPIPICLA 2005
Score = 31.6 bits (70), Expect = 1.6
Identities = 52/217 (23%), Positives = 77/217 (35%), Gaps = 42/217 (19%)
Query: 141 SRCEYYCSPGYTLKGERTVTCM----DNKAWSGRPASC-------------VDMEPPRIK 183
S YYC GY L+G T+TC+ W+ SC + P K
Sbjct: 1617 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPK 1676
Query: 184 CPSVKER----IAEPNKLTVRVSW-----------ETPEGRDTADGILTDVILKGLPPGS 228
SV IA P + V + E +G +L+ L G G
Sbjct: 1677 NYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSS--LSGSHSGE 1734
Query: 229 NFP--EGDH-KIQYTVYDRAENKG-TCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGA 284
+ P G+ I++T KG ++ R + PE + + + G+
Sbjct: 1735 SLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGS 1794
Query: 285 TCEFSCIGGYELQGSPARVCQ----SNLAWSGTEPTC 317
+ F C GY L GS A C+ S W+ + PTC
Sbjct: 1795 SVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1831
Score = 30.8 bits (68), Expect = 2.7
Identities = 23/100 (23%), Positives = 37/100 (37%), Gaps = 6/100 (6%)
Query: 224 LPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYG 283
LPP + ++ T G + +++ CG P G + + + G
Sbjct: 140 LPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRF--DVG 197
Query: 284 ATCEFSCIGGYELQGSPARVCQSN----LAWSGTEPTCAA 319
+SC+ GY L G P C +N +W P C A
Sbjct: 198 DKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Score = 30.4 bits (67), Expect = 3.6
Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 5/57 (8%)
Query: 80 ALGTRCDIRCQKGYELHGSSLLICQSNKR----WSD-KVICKQKRCPTLAMPANGGF 131
+LG+ C + Y L G+ + CQ WSD + +CK K C + +G F
Sbjct: 399 SLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTF 455
Score = 30.0 bits (66), Expect = 4.6
Identities = 47/235 (20%), Positives = 77/235 (32%), Gaps = 38/235 (16%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDN--KAWSGRPASCVDM 177
CP P++G K D + C GY+L+G +TCM + W+ C+
Sbjct: 1948 CPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2006
Query: 178 --------------------EPPRIKCP---------SVKERIAEPNKLTVRVSWETPEG 208
P + C V + + T+ E G
Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSG 2066
Query: 209 RDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK-GTCKFRVKVRVKRCGKLNA 267
++ + +P S F Y D ++NK G +++ C
Sbjct: 2067 SSETSTVIGRLSGPQIP-SSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRP 2125
Query: 268 PENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA--WSGTEPTCAAM 320
NG++ + G T F C GY L G+ A C ++ W+ P C A+
Sbjct: 2126 FRNGFV--IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2178
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 76.3 bits (186), Expect = 6e-14
Identities = 79/270 (29%), Positives = 106/270 (39%), Gaps = 60/270 (22%)
Query: 62 VKYGDVYCRAPQGGYYKTALGTRCDIRCQKGY--ELHGSSLLICQSNKRWSDKV-ICKQK 118
++YGD Y +G CQ GY EL+GS + C N WS + C+
Sbjct: 3183 LRYGDDY-----------VVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3231
Query: 119 RCPTLAMPANGGFKCVDGAYFN--SRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVD 176
CPT +NG ++G F+ Y CSPGY L +TC+ N WSG C+
Sbjct: 3232 TCPTPPQISNGR---LEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLP 3288
Query: 177 --MEPPRIKCPSVKERIAEPNKLTVRVSWETP---EGRDT----ADGILTDVILKGLPPG 227
P I +E + + V S P G T ADG + G
Sbjct: 3289 KFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWS---------G 3339
Query: 228 SNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCE 287
S+ H I+ T EN G V R G N ++ G G+ +
Sbjct: 3340 SS----PHCIEPT-QTSCENPG---------VPRHGSQN---------NTFGFQVGSVVQ 3376
Query: 288 FSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
F C G+ LQGS R C +L WSG +P C
Sbjct: 3377 FHCKKGHLLQGSTTRTCLPDLTWSGIQPEC 3406
Score = 75.9 bits (185), Expect = 7e-14
Identities = 73/282 (25%), Positives = 103/282 (36%), Gaps = 40/282 (14%)
Query: 74 GGYYKTALGTRCDIR--CQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGG 130
G ++ T+ +R C GY LHGS C +N W+ + CK +C ANG
Sbjct: 3065 GSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPGTTANGK 3124
Query: 131 FKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKER 190
+DG F+S Y C GY L G C N WSG +C + P+ R
Sbjct: 3125 VFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDPGIPANGLR 3184
Query: 191 IAEPNKLTVRVSWETPEGRD-----------TADGILTDV--------------ILKGLP 225
+ + VS+ G T +G + V I G
Sbjct: 3185 YGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCPTPPQISNGRL 3244
Query: 226 PGSNFPEG---------DHKIQYTVYDRAENKGTCKFRV-KVRVKRCGKLNAPENGYMKC 275
G+NF G +++ + GT V + K CG P G K
Sbjct: 3245 EGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQG--KR 3302
Query: 276 SSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
Y + FSC + L GS R+CQ++ WSG+ P C
Sbjct: 3303 EGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHC 3344
Score = 73.9 bits (180), Expect = 3e-13
Identities = 64/239 (26%), Positives = 90/239 (37%), Gaps = 39/239 (16%)
Query: 88 RCQKGYELHGSSLLICQSNKRWSDK------VICKQKRCPTLAMPANGGFKCVDGAYFNS 141
+C G+ L GSS+ ICQ + WS + V C P + GF FN
Sbjct: 2842 QCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFN------FND 2895
Query: 142 RCEYYCSPGYTLKGERTVTCMDNKAWSGRPASC--VDMEPPRIKCPSVKERIAEPNKLTV 199
+ C+ GY ++G C N+ WS P C V+ P I S +E E T
Sbjct: 2896 VVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY 2955
Query: 200 RVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRV 259
V+ PG F G +V N K + +
Sbjct: 2956 GT-----------------VVFYDCNPG-YFLFGS-----SVLICQPNGQWDKPLPECIM 2992
Query: 260 KRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCA 318
CG P N + S + +G+T +SC G L G +R CQ N WSG++P C+
Sbjct: 2993 IDCGHPGVPPNAVL--SGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCS 3049
Score = 73.2 bits (178), Expect = 5e-13
Identities = 73/278 (26%), Positives = 109/278 (39%), Gaps = 43/278 (15%)
Query: 61 KVKYGDVYCRAPQG---GYYKTALGTRCDI----RCQKGYELHGSSLLICQSNK----RW 109
+++Y YC P+ GY + G + + C +G+ L G S +C+ + W
Sbjct: 2561 RIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWACDRGFRLVGKSSAVCRKSSYGYHAW 2620
Query: 110 SDKV-ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGER--TVTCMDNKA 166
V C+ C P NGG D +R Y+C+ GY L + T C +
Sbjct: 2621 DAPVPACQAISCGIPKAPTNGGILTTD-YLVGTRVTYFCNDGYRLSSKELTTAVCQSDGT 2679
Query: 167 WS--GRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGL 224
WS + CV + CPS+ I E + W G T V+
Sbjct: 2680 WSNHNKTPRCV-----VVTCPSINSFILEHGR------WRIVNGSHYE--YKTKVVFSCD 2726
Query: 225 PPGSNFPEGDHKIQYTVYDRAENKGTCKFRVK---VRVKRCGKLNAPENGYMKCSSDGDN 281
P G H + + N GT +R + ++ CG+L P NG +
Sbjct: 2727 P-------GYHGLGPASIECLPN-GTWSWRNERPYCQIISCGELPTPPNG--NKIGTQTS 2776
Query: 282 YGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAA 319
YG+T F+C G+ L GS R C S+ WS +E C A
Sbjct: 2777 YGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLA 2814
Score = 71.6 bits (174), Expect = 1e-12
Identities = 72/312 (23%), Positives = 115/312 (36%), Gaps = 52/312 (16%)
Query: 55 PWCSPIKVKY--GDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDK 112
P C P+ + +Y R G+ + T C GY + G + CQ+N++WS
Sbjct: 2868 PSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT---FSCNIGYLMQGPTKAQCQANRQWSHP 2924
Query: 113 V-ICKQKRCPTLAMPANGG--FKCVDGAYFNSRCEYY-CSPGYTLKGERTVTCMDNKAWS 168
+CK C +PAN K G + +Y C+PGY L G + C N W
Sbjct: 2925 PPMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWD 2984
Query: 169 GRPASCVDME------PP---------------RIKCPSVKERIAEPNK---LTVRVSWE 204
C+ ++ PP C + + + ++ L S
Sbjct: 2985 KPLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGS 3044
Query: 205 TPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAE--------NKGTCKF--- 253
P A G D G P + E + + + TV + + TC
Sbjct: 3045 QPHCSGDATGTCGD---PGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGS 3101
Query: 254 ----RVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA 309
+ + + +CG NG + DG + ++ +SC+ GY L G R C +N
Sbjct: 3102 WTGRQPECKAVQCGNPGTTANGKV-FRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGT 3160
Query: 310 WSGTEPTCAAMN 321
WSGT P C ++
Sbjct: 3161 WSGTLPNCTIIS 3172
Score = 68.2 bits (165), Expect = 2e-11
Identities = 77/313 (24%), Positives = 115/313 (36%), Gaps = 77/313 (24%)
Query: 70 RAPQGGYYKTA---LGTRCDIRCQKGYELHGSSLL--ICQSNKRWSDKVICKQKRCPTLA 124
+AP G T +GTR C GY L L +CQS+ WS+ K RC +
Sbjct: 2636 KAPTNGGILTTDYLVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHN--KTPRCVVVT 2693
Query: 125 MPA-------NGGFKCVDGAYFNSRCE--YYCSPGYTLKGERTVTCMDNKAWSGRPASCV 175
P+ +G ++ V+G+++ + + + C PGY G ++ C+ N WS R
Sbjct: 2694 CPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWR----- 2748
Query: 176 DMEPPRIKCPSVKERIAEP--NKLTVRVS----------------------------WET 205
E P + S E P NK+ + S W
Sbjct: 2749 -NERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSE 2807
Query: 206 PEGRDTADGI-LTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKR--- 261
E R A + ++I+ G G N+ D + N G VR+ +
Sbjct: 2808 SETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQC------NPGFRLIGSSVRICQQDH 2861
Query: 262 -------------CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNL 308
CG +P Y + S +G N+ FSC GY +QG CQ+N
Sbjct: 2862 NWSGQLPSCVPVSCGHPGSPI--YGRTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR 2919
Query: 309 AWSGTEPTCAAMN 321
WS P C +N
Sbjct: 2920 QWSHPPPMCKVVN 2932
Score = 59.7 bits (143), Expect = 5e-09
Identities = 72/278 (25%), Positives = 89/278 (32%), Gaps = 40/278 (14%)
Query: 52 KDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWS- 110
K P C I + V A G K G+ C L G S CQ N WS
Sbjct: 2985 KPLPECIMIDCGHPGVPPNAVLSGE-KYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSG 3043
Query: 111 DKVICKQKRCPTLAMPANGGFKCVDGAYF--NSRCEYYCSPGYTLKGERTVTCMDNKAWS 168
+ C T P G + F S Y C GY L G TC+ N +W+
Sbjct: 3044 SQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWT 3103
Query: 169 GRPASC--VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPP 226
GR C V P RI + + V + EG + + G
Sbjct: 3104 GRQPECKAVQCGNPGTTANGKVFRI-DGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWS 3162
Query: 227 GSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNY--GA 284
G+ + CG P NG GD+Y G
Sbjct: 3163 GT-------------------------LPNCTIISCGDPGIPANGLRY----GDDYVVGQ 3193
Query: 285 TCEFSCIGGY--ELQGSPARVCQSNLAWSGTEPTCAAM 320
+ C GY EL GS R C N WSG PTC A+
Sbjct: 3194 NVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAV 3231
Score = 59.3 bits (142), Expect = 7e-09
Identities = 68/283 (24%), Positives = 102/283 (36%), Gaps = 34/283 (12%)
Query: 78 KTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDG 136
+T+ G+ C G+ L GS++ C S+ WS+ + C C + NG + +
Sbjct: 2774 QTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNG--QVIGE 2831
Query: 137 AY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
Y + Y C+PG+ L G C + WSG+ SCV + P
Sbjct: 2832 NYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIY-------- 2883
Query: 196 KLTVRVSWETPEGRDTADGI-LTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFR 254
GR + +G DV+ G +G K Q N+
Sbjct: 2884 ------------GRTSGNGFNFNDVVTFSCNIGY-LMQGPTKAQCQA-----NRQWSHPP 2925
Query: 255 VKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQGSPARVCQSNLAWSG 312
+V C P N + + N YG + C GY L GS +CQ N W
Sbjct: 2926 PMCKVVNCSDPGIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDK 2985
Query: 313 TEPTCAAMNV-NVGVRTAAALLDQFYEKRRLLIVSTPTARNLL 354
P C ++ + GV A L + Y + S R+LL
Sbjct: 2986 PLPECIMIDCGHPGVPPNAVLSGEKYTFGSTVHYSCTGKRSLL 3028
Score = 56.6 bits (135), Expect = 5e-08
Identities = 60/243 (24%), Positives = 89/243 (36%), Gaps = 45/243 (18%)
Query: 89 CQKGYELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYC 147
C GYEL ++L C N WS +V C K C +PA G + Y S + C
Sbjct: 3259 CSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIPAQGKREGKSFIY-QSEVSFSC 3317
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKC--PSVKERIAEPNKLTVRVS--- 202
+ + L G T C + WSG C+ EP + C P V ++ N +V
Sbjct: 3318 NFPFILVGSSTRICQADGTWSGSSPHCI--EPTQTSCENPGVPRHGSQNNTFGFQVGSVV 3375
Query: 203 -WETPEGR----DTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKV 257
+ +G T L D+ G+ P P
Sbjct: 3376 QFHCKKGHLLQGSTTRTCLPDLTWSGIQPEC-IPHS------------------------ 3410
Query: 258 RVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPA-RVCQSNLAWSGTEPT 316
C + P + + D ++G T ++C G+ L G RVC+S+ W+G P
Sbjct: 3411 ----CKQPETPAHANV-VGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPI 3465
Query: 317 CAA 319
C A
Sbjct: 3466 CEA 3468
Score = 55.1 bits (131), Expect = 1e-07
Identities = 66/243 (27%), Positives = 92/243 (37%), Gaps = 49/243 (20%)
Query: 89 CQKGYELHGSSLLICQSNKR--WSDKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYY 146
C GY LHGSSLL C + +R W + P+ G FK
Sbjct: 1381 CNPGYTLHGSSLLKCMTGERRAWDYPL-------PSCIAECGGRFK-------GESSGRI 1426
Query: 147 CSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETP 206
SPGY + + CM W ++++P I E + +RV W+ P
Sbjct: 1427 LSPGYPFPYDNNLRCM----W------MIEVDPGNIVSLQFLAFDTEASHDILRV-WDGP 1475
Query: 207 EGRDTADGILTDVILKGLPPGSNFPEGDHK------IQY-TVYDRAENKGTCKFRVKVRV 259
D++LK + GS PEG H IQ+ T + +++ +F V
Sbjct: 1476 PE--------NDMLLKEI-SGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSV-A 1525
Query: 260 KRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC---QSNLAWSGTEPT 316
C P NG + DG G T F C GYELQG C ++ W + P
Sbjct: 1526 TACRDPGVPMNGTR--NGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPV 1583
Query: 317 CAA 319
C A
Sbjct: 1584 CIA 1586
Score = 40.8 bits (94), Expect = 0.003
Identities = 28/105 (26%), Positives = 42/105 (40%), Gaps = 4/105 (3%)
Query: 73 QGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGF 131
Q + +G+ C+KG+ L GS+ C + WS + C C PA+
Sbjct: 3363 QNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIPHSCKQPETPAHANV 3422
Query: 132 KCVDGAYFNSRCEYYCSPGYTLKG--ERTVTCMDNKAWSGRPASC 174
+D Y C PG+ L G E V C + W+G+ C
Sbjct: 3423 VGMDLPSHGYTLIYTCQPGFFLAGGTEHRV-CRSDNTWTGKVPIC 3466
Score = 39.3 bits (90), Expect = 0.008
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 5/75 (6%)
Query: 246 ENKGTCKFRV---KVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPAR 302
E+ G+ F+V ++ + CG P G + DG + F C G+EL G +
Sbjct: 645 ESVGSVGFKVNYKEIEKESCGDPGTPLYGIRE--GDGFSNRDVLRFECQFGFELIGEKSI 702
Query: 303 VCQSNLAWSGTEPTC 317
VCQ N WS P C
Sbjct: 703 VCQENNQWSANIPIC 717
Score = 38.9 bits (89), Expect = 0.010
Identities = 57/239 (23%), Positives = 86/239 (35%), Gaps = 44/239 (18%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYT-LKGERTVTC--MDNKA-WSGRPASC- 174
CP +P N + D S C G+ +G T+TC MD K WSG C
Sbjct: 834 CPDPGIPINAR-RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCG 892
Query: 175 ------------VDMEP-------PRIKCPSVKERIAEPNKLTVRVSWETPEGR------ 209
V + P + C V E AEP ++++++E +
Sbjct: 893 APCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIE--AEPGH-SIKITFERFQTELNYDVL 949
Query: 210 DTADGILTDVILKGLPPGSNFPE---GDHKIQYTVYDRAENKGTCKFR-----VKVRVKR 261
+ DG L G G+ P+ Y ++ ++ F+ V V
Sbjct: 950 EVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYS 1009
Query: 262 CGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCAAM 320
C P +G + + G+T FSC GY L +C+ N WS PTC A+
Sbjct: 1010 CLDPGIPVHG--RRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDAL 1066
Score = 38.5 bits (88), Expect = 0.013
Identities = 56/251 (22%), Positives = 88/251 (35%), Gaps = 42/251 (16%)
Query: 77 YKTALGTRCDIRCQKGYELHGSSLLICQSNKR--WSDKVICKQKRCPTLAMPANGGFKCV 134
+ +G C GY L G+S +IC R WS + RC +C
Sbjct: 1196 FNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPL----PRCVA---------EC- 1241
Query: 135 DGAYFNSRCEYYCSPGYTLKGERTVTCMDN-KAWSGRPASCVDMEPPRIKCPSVKERIAE 193
GA + SP Y L E C+ + + +G+ I + +A+
Sbjct: 1242 -GASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKG----------INISARTFHLAQ 1290
Query: 194 PNKLTVRVSWETPEGRDTAD---GILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGT 250
+ L + +G+D G T ++GL S +++ ++G
Sbjct: 1291 GDVLKIY------DGKDKTTHLLGAFTGASMRGLTLSST--SNQLWLEFNSDTEGTDEGF 1342
Query: 251 CKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQS--NL 308
+ C P+ GY K S G G+T + C GY L GS C +
Sbjct: 1343 QLVYTSFELSHCEDPGIPQFGY-KISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERR 1401
Query: 309 AWSGTEPTCAA 319
AW P+C A
Sbjct: 1402 AWDYPLPSCIA 1412
Score = 38.1 bits (87), Expect = 0.017
Identities = 45/218 (20%), Positives = 79/218 (36%), Gaps = 42/218 (19%)
Query: 145 YYCSPGYTLKGERTVTCM--DNKAWSGRPASCVDMEP---------------------PR 181
Y C PG+TL G +TC + G P C + P P
Sbjct: 2421 YQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPN 2480
Query: 182 IKCPSVKERIAEPNKLTVRVSWETPEGR----DTADG--ILTDVILK---GLPPGSNFPE 232
++ + + + +T+ V + E DG I + V++ N
Sbjct: 2481 LQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNITS 2540
Query: 233 GDHKI--QYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSC 290
H++ Q++ KG FR++ C +P +GY+ S G + ++C
Sbjct: 2541 NGHEVFLQWSADHGNNKKG---FRIRYIAFYCSTPESPPHGYI-ISQTGGQLNSVVRWAC 2596
Query: 291 IGGYELQGSPARVCQSNL----AWSGTEPTCAAMNVNV 324
G+ L G + VC+ + AW P C A++ +
Sbjct: 2597 DRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGI 2634
Score = 36.6 bits (83), Expect = 0.050
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 14/92 (15%)
Query: 230 FPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFS 289
FP D+ ++++ N+G +K C PENG K + G+T +FS
Sbjct: 462 FPGKDNSNKFSIL----NEGG----IKTASNLCPDPGEPENG--KRIGSDFSLGSTVQFS 511
Query: 290 CIGGYELQGSPARVCQS----NLAWSGTEPTC 317
C Y LQG+ + CQ AWS P C
Sbjct: 512 CDEDYVLQGAKSITCQRIAEVFAAWSDHRPVC 543
Score = 32.7 bits (73), Expect = 0.72
Identities = 13/28 (46%), Positives = 18/28 (64%), Gaps = 1/28 (3%)
Query: 89 CQKGYELHGSSLLICQSNKRWSDKV-IC 115
CQ G+EL G ++CQ N +WS + IC
Sbjct: 690 CQFGFELIGEKSIVCQENNQWSANIPIC 717
Score = 32.3 bits (72), Expect = 0.94
Identities = 18/70 (25%), Positives = 27/70 (38%), Gaps = 6/70 (8%)
Query: 106 NKRWSDKVICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNK 165
N + +K C P + GF D F C G+ L GE+++ C +N
Sbjct: 655 NYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFE------CQFGFELIGEKSIVCQENN 708
Query: 166 AWSGRPASCV 175
WS C+
Sbjct: 709 QWSANIPICI 718
Score = 32.3 bits (72), Expect = 0.94
Identities = 54/254 (21%), Positives = 83/254 (32%), Gaps = 53/254 (20%)
Query: 80 ALGTRCDIRCQKGYELHGSSLLICQ----SNKRWSDKVICKQKRCPTLAMPANGGFKCVD 135
A+G+ C GY LHGS + C+ S +W+D + PT +P
Sbjct: 1895 AVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSL-------PTCIVPC-------- 1939
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPN 195
G R SPGY + + C+ W +I P +
Sbjct: 1940 GGILTKRKGTILSPGYPEPYDNNLNCV----W-------------KITVPEGAGIQVQVV 1982
Query: 196 KLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK---GTCK 252
+W++ D DG + G G+ P + +Y ++
Sbjct: 1983 SFATEHNWDS---LDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAG 2039
Query: 253 FRVK---VRVKRCGKLNAPENGYMKCSSDGDNY--GATCEFSCIGGYELQGSPARVCQSN 307
F ++ + + C + P +G GD Y G F C GY LQG C
Sbjct: 2040 FHLEYTAIGLDSCPEPQTPSSGI----KIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPG 2095
Query: 308 --LAWSGTEPTCAA 319
W+ P C A
Sbjct: 2096 PVRRWNYPIPICLA 2109
Score = 31.6 bits (70), Expect = 1.6
Identities = 52/217 (23%), Positives = 77/217 (35%), Gaps = 42/217 (19%)
Query: 141 SRCEYYCSPGYTLKGERTVTCM----DNKAWSGRPASC-------------VDMEPPRIK 183
S YYC GY L+G T+TC+ W+ SC + P K
Sbjct: 1721 STVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPK 1780
Query: 184 CPSVKER----IAEPNKLTVRVSW-----------ETPEGRDTADGILTDVILKGLPPGS 228
SV IA P + V + E +G +L+ L G G
Sbjct: 1781 NYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSS--LSGSHSGE 1838
Query: 229 NFP--EGDH-KIQYTVYDRAENKG-TCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGA 284
+ P G+ I++T KG ++ R + PE + + + G+
Sbjct: 1839 SLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGS 1898
Query: 285 TCEFSCIGGYELQGSPARVCQ----SNLAWSGTEPTC 317
+ F C GY L GS A C+ S W+ + PTC
Sbjct: 1899 SVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTC 1935
Score = 30.8 bits (68), Expect = 2.7
Identities = 23/100 (23%), Positives = 37/100 (37%), Gaps = 6/100 (6%)
Query: 224 LPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYG 283
LPP + ++ T G + +++ CG P G + + + G
Sbjct: 140 LPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRF--DVG 197
Query: 284 ATCEFSCIGGYELQGSPARVCQSN----LAWSGTEPTCAA 319
+SC+ GY L G P C +N +W P C A
Sbjct: 198 DKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRA 237
Score = 30.4 bits (67), Expect = 3.6
Identities = 17/57 (29%), Positives = 26/57 (45%), Gaps = 5/57 (8%)
Query: 80 ALGTRCDIRCQKGYELHGSSLLICQSNKR----WSD-KVICKQKRCPTLAMPANGGF 131
+LG+ C + Y L G+ + CQ WSD + +CK K C + +G F
Sbjct: 503 SLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTF 559
Score = 30.0 bits (66), Expect = 4.6
Identities = 47/235 (20%), Positives = 77/235 (32%), Gaps = 38/235 (16%)
Query: 120 CPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDN--KAWSGRPASCVDM 177
CP P++G K D + C GY+L+G +TCM + W+ C+
Sbjct: 2052 CPEPQTPSSG-IKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2110
Query: 178 --------------------EPPRIKCP---------SVKERIAEPNKLTVRVSWETPEG 208
P + C V + + T+ E G
Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSG 2170
Query: 209 RDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK-GTCKFRVKVRVKRCGKLNA 267
++ + +P S F Y D ++NK G +++ C
Sbjct: 2171 SSETSTVIGRLSGPQIP-SSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRP 2229
Query: 268 PENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLA--WSGTEPTCAAM 320
NG++ + G T F C GY L G+ A C ++ W+ P C A+
Sbjct: 2230 FRNGFV--IGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEAL 2282
>gi|27502421 CD46 antigen, complement regulatory protein isoform 13
precursor [Homo sapiens]
Length = 373
Score = 70.5 bits (171), Expect = 3e-12
Identities = 78/274 (28%), Positives = 111/274 (40%), Gaps = 47/274 (17%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTCAAMNVNVGVRTAAA 331
GS VC SN W P C ++ + ++ A+
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPAS 297
>gi|27502417 CD46 antigen, complement regulatory protein isoform 10
precursor [Homo sapiens]
Length = 370
Score = 70.5 bits (171), Expect = 3e-12
Identities = 78/274 (28%), Positives = 111/274 (40%), Gaps = 47/274 (17%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTCAAMNVNVGVRTAAA 331
GS VC SN W P C ++ + ++ A+
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPAS 297
Score = 37.7 bits (86), Expect = 0.022
Identities = 29/120 (24%), Positives = 42/120 (35%), Gaps = 18/120 (15%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPE 207
G+ L G T+ C N W +PP KC V + + + PE
Sbjct: 257 DKGFYLDGSDTIVCDSNSTW----------DPPVPKCLKVSTSSTTKSPASSASGYPKPE 306
>gi|27502415 CD46 antigen, complement regulatory protein isoform 9
precursor [Homo sapiens]
Length = 363
Score = 70.5 bits (171), Expect = 3e-12
Identities = 78/274 (28%), Positives = 111/274 (40%), Gaps = 47/274 (17%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTCAAMNVNVGVRTAAA 331
GS VC SN W P C ++ + ++ A+
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPAS 297
Score = 37.7 bits (86), Expect = 0.022
Identities = 29/120 (24%), Positives = 42/120 (35%), Gaps = 18/120 (15%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPE 207
G+ L G T+ C N W +PP KC V + + + PE
Sbjct: 257 DKGFYLDGSDTIVCDSNSTW----------DPPVPKCLKVSTSSTTKSPASSASGYPKPE 306
>gi|27502407 CD46 antigen, complement regulatory protein isoform 3
precursor [Homo sapiens]
Length = 377
Score = 70.5 bits (171), Expect = 3e-12
Identities = 78/274 (28%), Positives = 111/274 (40%), Gaps = 47/274 (17%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTCAAMNVNVGVRTAAA 331
GS VC SN W P C ++ + ++ A+
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPAS 297
>gi|24432108 CD46 antigen, complement regulatory protein isoform 4
precursor [Homo sapiens]
Length = 384
Score = 70.5 bits (171), Expect = 3e-12
Identities = 78/274 (28%), Positives = 111/274 (40%), Gaps = 47/274 (17%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTCAAMNVNVGVRTAAA 331
GS VC SN W P C ++ + ++ A+
Sbjct: 264 GSDTIVCDSNSTWDPPVPKCLKVSTSSTTKSPAS 297
>gi|41152076 steroid-sensitive protein 1 [Homo sapiens]
Length = 950
Score = 69.7 bits (169), Expect = 5e-12
Identities = 46/142 (32%), Positives = 73/142 (51%), Gaps = 12/142 (8%)
Query: 333 LDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRI-- 390
L +F +RRLL++S P + Y QL L C LRHIT+++L+GV + G +
Sbjct: 772 LSRFRWRRRLLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGVLEL 831
Query: 391 ----GAKI-----MPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVS-LVMPVALFN 440
G+ + +P L +R ++ FSM+LV K G K Y S + V +++
Sbjct: 832 FPINGSSVVEREDVPAHLVKDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYD 891
Query: 441 LIDTFPLRKEEMVLQAEMSQTC 462
LID+ LR++EM +Q + C
Sbjct: 892 LIDSMQLRRQEMAIQQSLGMRC 913
Score = 52.4 bits (124), Expect = 9e-07
Identities = 42/141 (29%), Positives = 65/141 (46%), Gaps = 10/141 (7%)
Query: 332 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQ-AQCGLDLRHITVVELVGVFP------ 384
+L F K R+ ++S P A YRL + +L+ C L RHI + L
Sbjct: 141 ILASFAGKNRVWVISAPHASEGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKV 200
Query: 385 ---TLIGRIGAKIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVSLVMPVALFNL 441
T G+I + + P+L +L L++ F MVL+ K +ERY V A++ +
Sbjct: 201 RRITSEGQILEQPLDPSLIPKLMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEV 260
Query: 442 IDTFPLRKEEMVLQAEMSQTC 462
ID P+R+ E + Q Q C
Sbjct: 261 IDQGPIRRIEKIRQKGFVQKC 281
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/151 (26%), Positives = 65/151 (43%), Gaps = 15/151 (9%)
Query: 327 RTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTL 386
++ A LL F KRRLL+++ P A N +Y Q ++ C + R I+V+ + G
Sbjct: 610 KSVADLLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNS 669
Query: 387 IGRIG---------------AKIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVS 431
+I ++ L +LR + F MVL D K+ Y
Sbjct: 670 TMKIDHFQLDNEKPMRVVDDEDLVDQRLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEV 729
Query: 432 LVMPVALFNLIDTFPLRKEEMVLQAEMSQTC 462
+ ++F+LIDTF R ++M Q + C
Sbjct: 730 PITMKSVFDLIDTFQSRIKDMEKQKKEGIVC 760
>gi|41152074 steroid-sensitive protein 1 [Homo sapiens]
Length = 950
Score = 69.7 bits (169), Expect = 5e-12
Identities = 46/142 (32%), Positives = 73/142 (51%), Gaps = 12/142 (8%)
Query: 333 LDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRI-- 390
L +F +RRLL++S P + Y QL L C LRHIT+++L+GV + G +
Sbjct: 772 LSRFRWRRRLLVISAPNDEDWAYSQQLSALSGQACNFGLRHITILKLLGVGEEVGGVLEL 831
Query: 391 ----GAKI-----MPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVS-LVMPVALFN 440
G+ + +P L +R ++ FSM+LV K G K Y S + V +++
Sbjct: 832 FPINGSSVVEREDVPAHLVKDIRNYFQVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYD 891
Query: 441 LIDTFPLRKEEMVLQAEMSQTC 462
LID+ LR++EM +Q + C
Sbjct: 892 LIDSMQLRRQEMAIQQSLGMRC 913
Score = 52.4 bits (124), Expect = 9e-07
Identities = 42/141 (29%), Positives = 65/141 (46%), Gaps = 10/141 (7%)
Query: 332 LLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQ-AQCGLDLRHITVVELVGVFP------ 384
+L F K R+ ++S P A YRL + +L+ C L RHI + L
Sbjct: 141 ILASFAGKNRVWVISAPHASEGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKV 200
Query: 385 ---TLIGRIGAKIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVSLVMPVALFNL 441
T G+I + + P+L +L L++ F MVL+ K +ERY V A++ +
Sbjct: 201 RRITSEGQILEQPLDPSLIPKLMSFLKLEKGKFGMVLLKKTLQVEERYPYPVRLEAMYEV 260
Query: 442 IDTFPLRKEEMVLQAEMSQTC 462
ID P+R+ E + Q Q C
Sbjct: 261 IDQGPIRRIEKIRQKGFVQKC 281
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/151 (26%), Positives = 65/151 (43%), Gaps = 15/151 (9%)
Query: 327 RTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLRHITVVELVGVFPTL 386
++ A LL F KRRLL+++ P A N +Y Q ++ C + R I+V+ + G
Sbjct: 610 KSVADLLGSFEGKRRLLLITAPKAENNMYVQQRDEYLESFCKMATRKISVITIFGPVNNS 669
Query: 387 IGRIG---------------AKIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVS 431
+I ++ L +LR + F MVL D K+ Y
Sbjct: 670 TMKIDHFQLDNEKPMRVVDDEDLVDQRLISELRKEYGMTYNDFFMVLTDVDLRVKQYYEV 729
Query: 432 LVMPVALFNLIDTFPLRKEEMVLQAEMSQTC 462
+ ++F+LIDTF R ++M Q + C
Sbjct: 730 PITMKSVFDLIDTFQSRIKDMEKQKKEGIVC 760
>gi|27502419 CD46 antigen, complement regulatory protein isoform 11
precursor [Homo sapiens]
Length = 348
Score = 68.9 bits (167), Expect = 9e-12
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 47/260 (18%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTC 317
GS VC SN W P C
Sbjct: 264 GSDTIVCDSNSTWDPPVPKC 283
Score = 37.4 bits (85), Expect = 0.029
Identities = 24/92 (26%), Positives = 34/92 (36%), Gaps = 8/92 (8%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEP 179
G+ L G T+ C N W C+ P
Sbjct: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKGYP 288
>gi|27502413 CD46 antigen, complement regulatory protein isoform 7
precursor [Homo sapiens]
Length = 378
Score = 68.9 bits (167), Expect = 9e-12
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 47/260 (18%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTC 317
GS VC SN W P C
Sbjct: 264 GSDTIVCDSNSTWDPPVPKC 283
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/93 (26%), Positives = 36/93 (38%), Gaps = 8/93 (8%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPP 180
G+ L G T+ C N W C+ + PP
Sbjct: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
>gi|27502411 CD46 antigen, complement regulatory protein isoform 6
precursor [Homo sapiens]
Length = 369
Score = 68.9 bits (167), Expect = 9e-12
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 47/260 (18%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTC 317
GS VC SN W P C
Sbjct: 264 GSDTIVCDSNSTWDPPVPKC 283
Score = 39.7 bits (91), Expect = 0.006
Identities = 26/98 (26%), Positives = 36/98 (36%), Gaps = 8/98 (8%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCP 185
G+ L G T+ C N W C+ P K P
Sbjct: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPP 294
Score = 34.3 bits (77), Expect = 0.25
Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 5/54 (9%)
Query: 76 YYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTLAMPAN 128
YYK + CD KG+ L GS ++C SN W V C + PT P +
Sbjct: 247 YYKATVMFECD----KGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296
>gi|27502409 CD46 antigen, complement regulatory protein isoform 5
precursor [Homo sapiens]
Length = 362
Score = 68.9 bits (167), Expect = 9e-12
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 47/260 (18%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTC 317
GS VC SN W P C
Sbjct: 264 GSDTIVCDSNSTWDPPVPKC 283
Score = 39.7 bits (91), Expect = 0.006
Identities = 26/98 (26%), Positives = 36/98 (36%), Gaps = 8/98 (8%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCP 185
G+ L G T+ C N W C+ P K P
Sbjct: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPP 294
Score = 34.3 bits (77), Expect = 0.25
Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 5/54 (9%)
Query: 76 YYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTLAMPAN 128
YYK + CD KG+ L GS ++C SN W V C + PT P +
Sbjct: 247 YYKATVMFECD----KGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296
>gi|27502405 CD46 antigen, complement regulatory protein isoform 14
precursor [Homo sapiens]
Length = 349
Score = 68.9 bits (167), Expect = 9e-12
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 47/260 (18%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTC 317
GS VC SN W P C
Sbjct: 264 GSDTIVCDSNSTWDPPVPKC 283
Score = 39.7 bits (91), Expect = 0.006
Identities = 26/98 (26%), Positives = 36/98 (36%), Gaps = 8/98 (8%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCP 185
G+ L G T+ C N W C+ P K P
Sbjct: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPP 294
Score = 34.3 bits (77), Expect = 0.25
Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 5/54 (9%)
Query: 76 YYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKRCPTLAMPAN 128
YYK + CD KG+ L GS ++C SN W V C + PT P +
Sbjct: 247 YYKATVMFECD----KGFYLDGSDTIVCDSNSTWDPPVPKCLKGPRPTYKPPVS 296
>gi|27502402 CD46 antigen, complement regulatory protein isoform 1
precursor [Homo sapiens]
Length = 392
Score = 68.9 bits (167), Expect = 9e-12
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 47/260 (18%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTC 317
GS VC SN W P C
Sbjct: 264 GSDTIVCDSNSTWDPPVPKC 283
Score = 42.0 bits (97), Expect = 0.001
Identities = 34/144 (23%), Positives = 48/144 (33%), Gaps = 19/144 (13%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPE 207
G+ L G T+ C N W C+ + PP P + T +
Sbjct: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASG 316
Query: 208 GRDTADGILTDVILKGLPPGSNFP 231
R T PP SN+P
Sbjct: 317 PRPTYK-----------PPVSNYP 329
>gi|27502427 CD46 antigen, complement regulatory protein isoform 12
precursor [Homo sapiens]
Length = 355
Score = 68.9 bits (167), Expect = 9e-12
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 47/260 (18%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTC 317
GS VC SN W P C
Sbjct: 264 GSDTIVCDSNSTWDPPVPKC 283
Score = 37.4 bits (85), Expect = 0.029
Identities = 24/92 (26%), Positives = 34/92 (36%), Gaps = 8/92 (8%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEP 179
G+ L G T+ C N W C+ P
Sbjct: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKGYP 288
>gi|27502425 CD46 antigen, complement regulatory protein isoform 8
precursor [Homo sapiens]
Length = 385
Score = 68.9 bits (167), Expect = 9e-12
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 47/260 (18%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTC 317
GS VC SN W P C
Sbjct: 264 GSDTIVCDSNSTWDPPVPKC 283
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/93 (26%), Positives = 36/93 (38%), Gaps = 8/93 (8%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPP 180
G+ L G T+ C N W C+ + PP
Sbjct: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPP 289
>gi|27502423 CD46 antigen, complement regulatory protein isoform 2
precursor [Homo sapiens]
Length = 399
Score = 68.9 bits (167), Expect = 9e-12
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 47/260 (18%)
Query: 76 YYKTALGTRCDIRCQKGYELHG--SSLLICQSNKRW---SDKVICKQKRCPTLAMPANGG 130
YY+ +G R D +C+KGY ++ IC N W SD C ++ CP + P NG
Sbjct: 53 YYE--IGERVDYKCKKGYFYIPPLATHTICDRNHTWLPVSDDA-CYRETCPYIRDPLNGQ 109
Query: 131 FKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRIK 183
+G Y F + + C+ GY L GE + C WSG+P C + PP+IK
Sbjct: 110 AVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIK 169
Query: 184 CPSVKERIAEPNKL----TVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQY 239
+ K +E V S + G D I I G
Sbjct: 170 --NGKHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCG--------------DN 213
Query: 240 TVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDN--YGATCEFSCIGGYELQ 297
+V+ RA + CK V +C + ENG + S G Y AT F C G+ L
Sbjct: 214 SVWSRAAPE--CK------VVKC-RFPVVENG-KQISGFGKKFYYKATVMFECDKGFYLD 263
Query: 298 GSPARVCQSNLAWSGTEPTC 317
GS VC SN W P C
Sbjct: 264 GSDTIVCDSNSTWDPPVPKC 283
Score = 42.0 bits (97), Expect = 0.001
Identities = 34/144 (23%), Positives = 48/144 (33%), Gaps = 19/144 (13%)
Query: 93 YELHGSSLLICQSNKRWSDKVI-CKQKRCPTLAMPANGGFKCVDGA----YFNSRCEYYC 147
+ L G S + C N WS CK +C P K + G Y+ + + C
Sbjct: 200 FSLIGESTIYCGDNSVWSRAAPECKVVKC---RFPVVENGKQISGFGKKFYYKATVMFEC 256
Query: 148 SPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPE 207
G+ L G T+ C N W C+ + PP P + T +
Sbjct: 257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHSVSTSSTTKSPASSASG 316
Query: 208 GRDTADGILTDVILKGLPPGSNFP 231
R T PP SN+P
Sbjct: 317 PRPTYK-----------PPVSNYP 329
>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
sapiens]
Length = 569
Score = 59.3 bits (142), Expect = 7e-09
Identities = 34/112 (30%), Positives = 52/112 (46%), Gaps = 10/112 (8%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQ---SNKRWSDKV-ICKQKRCPTLAMPANGGFKCVDG 136
LG + D C +G++L GSS C W+ V +C++K C T +P NG +
Sbjct: 370 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCETPPVPVNGMVHVITD 429
Query: 137 AYFNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDM---EPPRI 182
+ SR Y C+ G+ L G + C+ + WS +P C + PP I
Sbjct: 430 IHVGSRINYSCTTGHRLIGHSSAECILSGNTAHWSMKPPICQQIFCPNPPAI 481
Score = 51.6 bits (122), Expect = 1e-06
Identities = 31/102 (30%), Positives = 45/102 (44%), Gaps = 5/102 (4%)
Query: 77 YKTALGTRCDIRCQKGYELHGSSLLICQSNKRW-SDKVICKQKRCPTLAMPANGGFKCVD 135
++ +GT + C+ GY S+ IC N W S K CK+K C P NG +
Sbjct: 53 FEFPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTSAKDKCKRKSCRNPPDPVNGMAHVIK 111
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASC 174
F S+ +Y C GY L G + TC+ + W + C
Sbjct: 112 DIQFRSQIKYSCPKGYRLIGSSSATCIISGNTVIWDNKTPVC 153
Score = 46.6 bits (109), Expect = 5e-05
Identities = 58/247 (23%), Positives = 90/247 (36%), Gaps = 46/247 (18%)
Query: 86 DIRCQKGYELHGSSLLICQSNKRWSDKVICKQKRC--PTLAMPANGGFKCVDGAYFNSRC 143
+ RCQ G+ + G S + CQ+ +W ++ + C P + A + D
Sbjct: 255 EFRCQPGFGMKGPSHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEV 314
Query: 144 EYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIAE-PN------- 195
Y C PGY L+G + C WS PA+ PR + S + + + PN
Sbjct: 315 FYSCEPGYDLRGSTYLHCTPQGDWS--PAA------PRCEVKSCDDFLGQLPNGHVLFPL 366
Query: 196 --KLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKF 253
+L +V + EG + +L G+ E V +R
Sbjct: 367 NLQLGAKVDFVCDEGFQLKGSSASYCVLAGM-------ESLWNSSVPVCER--------- 410
Query: 254 RVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC--QSNLA-W 310
K C P NG + +D + G+ +SC G+ L G + C N A W
Sbjct: 411 ------KSCETPPVPVNGMVHVITD-IHVGSRINYSCTTGHRLIGHSSAECILSGNTAHW 463
Query: 311 SGTEPTC 317
S P C
Sbjct: 464 SMKPPIC 470
Score = 38.9 bits (89), Expect = 0.010
Identities = 67/286 (23%), Positives = 96/286 (33%), Gaps = 49/286 (17%)
Query: 54 TPWCS------PIKVKYGDVYCRAPQGGYYKTALGTRCDI--RCQKGYELHGSSLLICQS 105
TP C P + GD + + +Y + + C++ R +K +EL G + C S
Sbjct: 150 TPVCDRIICGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTS 209
Query: 106 NKR----WSDKVICKQKRCPTLAMPAN--GGFKCVDGAYF---NSRCEYYCSPGYTLKGE 156
WS Q P P N G D N E+ C PG+ +KG
Sbjct: 210 KDDQVGIWSGPA--PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKGP 267
Query: 157 RTVTCMDNKAWSGRPASC--VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADG 214
V C W SC V PP + +R + V + G D
Sbjct: 268 SHVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYD---- 323
Query: 215 ILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMK 274
L+G P+GD R E K F L NG++
Sbjct: 324 ------LRGSTYLHCTPQGDWS---PAAPRCEVKSCDDF-----------LGQLPNGHVL 363
Query: 275 CSSDGDNYGATCEFSCIGGYELQGSPARVC---QSNLAWSGTEPTC 317
+ GA +F C G++L+GS A C W+ + P C
Sbjct: 364 FPLN-LQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 408
>gi|67782358 complement factor B preproprotein [Homo sapiens]
Length = 764
Score = 58.5 bits (140), Expect = 1e-08
Identities = 48/149 (32%), Positives = 62/149 (41%), Gaps = 20/149 (13%)
Query: 72 PQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV-ICKQKR--CPTLAMPAN 128
P+ YY + C GY L GS+ CQ N RWS + IC C +P
Sbjct: 116 PRSPYYNVS--DEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPI- 172
Query: 129 GGFKCVDGAY-FNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSV 187
G + V Y Y+CS G TL+G + TC + +WSG SC D
Sbjct: 173 -GTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDS-----FMYDT 226
Query: 188 KERIAEP--NKLTVRVSWETPEGRDTADG 214
+ +AE + LT ET EG D DG
Sbjct: 227 PQEVAEAFLSSLT-----ETIEGVDAEDG 250
Score = 46.2 bits (108), Expect = 6e-05
Identities = 29/103 (28%), Positives = 44/103 (42%), Gaps = 11/103 (10%)
Query: 226 PGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGA- 284
P S + +I + YD +G+ +V + G+ +NG CS+ G G
Sbjct: 116 PRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTR 175
Query: 285 ----------TCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
+ + C G L+GS R CQ +WSGTEP+C
Sbjct: 176 KVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSC 218
Score = 39.7 bits (91), Expect = 0.006
Identities = 24/66 (36%), Positives = 27/66 (40%), Gaps = 5/66 (7%)
Query: 257 VRVKRCGKLNAP-----ENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWS 311
VR C ++ P ENG S N F C GY L+GS R CQ N WS
Sbjct: 93 VRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWS 152
Query: 312 GTEPTC 317
G C
Sbjct: 153 GQTAIC 158
>gi|86793109 complement receptor 1 isoform S precursor [Homo
sapiens]
Length = 2489
Score = 58.5 bits (140), Expect = 1e-08
Identities = 71/296 (23%), Positives = 109/296 (36%), Gaps = 58/296 (19%)
Query: 77 YKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVD 135
++ +GT + C+ GY S+ IC N W+ K C++K C P NG +
Sbjct: 61 FEFPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIK 119
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDME---PPRI------- 182
G F S+ +Y C+ GY L G + TC+ D W C + PP I
Sbjct: 120 GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIS 179
Query: 183 --------------KC------PSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILK 222
+C V E + EP+ S + G + + K
Sbjct: 180 TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS--IYCTSNDDQVGIWSGPAPQCIIPNK 237
Query: 223 GLPPG--SNFPEGDHKIQYTVYDRAENKGTCKFRVK-VRVKRCGKLNAPENGYMKCS--- 276
PP + D++ +++ + E + F +K R +C LN E CS
Sbjct: 238 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 297
Query: 277 -------------SDGDNY--GATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
D DN+ G +SC GY+L+G+ + C WS PTC
Sbjct: 298 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353
Score = 52.8 bits (125), Expect = 7e-07
Identities = 72/292 (24%), Positives = 106/292 (36%), Gaps = 58/292 (19%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDGAYF 139
+GT C+ Y S+ C N WS K +CK+K C T P NG +
Sbjct: 515 IGTSLKYECRPEYYGRPFSIT-CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 573
Query: 140 NSRCEYYCSPGYTLKGERTVTCM--DNKA-WSGRPASCVDME---PPRI----------- 182
SR Y C+ G+ L G + C+ N A WS +P C + PP I
Sbjct: 574 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 633
Query: 183 ----------KC------PSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPP 226
+C V E + EP+ S + G + + K PP
Sbjct: 634 NFHYGSVVTYRCNPGSGGRKVFELVGEPS--IYCTSNDDQVGIWSGPAPQCIIPNKCTPP 691
Query: 227 G--SNFPEGDHKIQYTVYDRAENKGTCKFRVK-VRVKRCGKLNAPENGYMKCS------- 276
+ D++ +++ + E + F +K R +C LN E CS
Sbjct: 692 NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 751
Query: 277 ---------SDGDNY--GATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
D DN+ G +SC GY+L+G+ + C WS PTC
Sbjct: 752 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 803
Score = 52.8 bits (125), Expect = 7e-07
Identities = 72/292 (24%), Positives = 106/292 (36%), Gaps = 58/292 (19%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDGAYF 139
+GT C+ Y S+ C N WS K +CK+K C T P NG +
Sbjct: 965 IGTSLKYECRPEYYGRPFSIT-CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 1023
Query: 140 NSRCEYYCSPGYTLKGERTVTCM--DNKA-WSGRPASCVDME---PPRI----------- 182
SR Y C+ G+ L G + C+ N A WS +P C + PP I
Sbjct: 1024 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 1083
Query: 183 ----------KC------PSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPP 226
+C V E + EP+ S + G + + K PP
Sbjct: 1084 NFHYGSVVTYRCNPGSGGRKVFELVGEPS--IYCTSNDDQVGIWSGPAPQCIIPNKCTPP 1141
Query: 227 G--SNFPEGDHKIQYTVYDRAENKGTCKFRVK-VRVKRCGKLNAPENGYMKCS------- 276
+ D++ +++ + E + F +K R +C LN E CS
Sbjct: 1142 NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 1201
Query: 277 ---------SDGDNY--GATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
D DN+ G +SC GY+L+G+ + C WS PTC
Sbjct: 1202 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 1253
Score = 52.0 bits (123), Expect = 1e-06
Identities = 70/292 (23%), Positives = 107/292 (36%), Gaps = 56/292 (19%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDGAYF 139
+GT C+ Y S+ C N WS K +CK+K C T P NG +
Sbjct: 1415 IGTSLKYECRPEYYGRPFSIT-CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 1473
Query: 140 NSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDME---PPRIK----CPSVKE 189
SR Y C+ G+ L G + C+ + WS +P C + PP I + +E
Sbjct: 1474 GSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 1533
Query: 190 RIAEPNKLTVRVSWETPEGR----------------DTADGILTDVILKGLPPGSNFPE- 232
+ +T R + + GR D GI + + + P P
Sbjct: 1534 NFHYGSVVTYRCNLGS-RGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN 1592
Query: 233 -------GDHKIQYTVYDRAENKGTCKFRVK-VRVKRCGKLNAPENGYMKCS-------- 276
D++ +++ + E + F +K R +C LN E CS
Sbjct: 1593 VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPE 1652
Query: 277 --------SDGDNY--GATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCA 318
S DN+ G +SC GY+L+G+ + C WS P CA
Sbjct: 1653 ILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCA 1704
Score = 47.8 bits (112), Expect = 2e-05
Identities = 74/309 (23%), Positives = 106/309 (34%), Gaps = 65/309 (21%)
Query: 34 SGDSPLEDDEVGYSHPRYKDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRC--QK 91
SGD+ + D+E P P P + GD + +Y + + RC+ +K
Sbjct: 148 SGDTVIWDNET----PICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRK 203
Query: 92 GYELHGSSLLICQSNKR----WSDKVICKQKRCPTLAMPAN--GGFKCVDGAYF---NSR 142
+EL G + C SN WS Q P P N G D N
Sbjct: 204 VFELVGEPSIYCTSNDDQVGIWSGPA--PQCIIPNKCTPPNVENGILVSDNRSLFSLNEV 261
Query: 143 CEYYCSPGYTLKGERTVTCMDNKAWSGRPASC--VDMEPPRIKCPSVKERIAEPNKLTVR 200
E+ C PG+ +KG R V C W SC V PP + +R +
Sbjct: 262 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 321
Query: 201 VSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVK 260
V + G D L+G P+GD + TC+ VK
Sbjct: 322 VFYSCEPGYD----------LRGAASMRCTPQGDW---------SPAAPTCE------VK 356
Query: 261 RC---------GKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC---QSNL 308
C G++ P N + GA +F C G++L+GS A C
Sbjct: 357 SCDDFMGQLLNGRVLFPVNLQL---------GAKVDFVCDEGFQLKGSSASYCVLAGMES 407
Query: 309 AWSGTEPTC 317
W+ + P C
Sbjct: 408 LWNSSVPVC 416
Score = 47.8 bits (112), Expect = 2e-05
Identities = 60/260 (23%), Positives = 92/260 (35%), Gaps = 48/260 (18%)
Query: 79 TALGTRCDIRCQKGYELHGS---SLLICQSNKRWSDKV-ICKQKRCPTLAMPANGGFKCV 134
T G+ + C +G+ L GS + L+ +N W K IC+ C +NG F
Sbjct: 1924 TQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSN 1983
Query: 135 DGAYFNSRC--EYYCSPG------YTLKGERTVTCMDNK----AWSGRPASCVDMEPPRI 182
+ F++ Y C G + L GER++ C WS P C+ +
Sbjct: 1984 NRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTN--KC 2041
Query: 183 KCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVY 242
P V+ I P + LT++I PG G H +Q
Sbjct: 2042 TAPEVENAIRVPGNRSFFT--------------LTEIIRFRCQPGFVMV-GSHTVQCQTN 2086
Query: 243 DRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCS---SDGDNY--GATCEFSCIGGYELQ 297
R K + C ++ P + S DN+ G +SC Y+L+
Sbjct: 2087 GRWGPK----------LPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
Query: 298 GSPARVCQSNLAWSGTEPTC 317
G+ + C WS P C
Sbjct: 2137 GAASLHCTPQGDWSPEAPRC 2156
Score = 46.6 bits (109), Expect = 5e-05
Identities = 59/254 (23%), Positives = 90/254 (35%), Gaps = 32/254 (12%)
Query: 77 YKTALGTRCDIRCQKGYELHGSSLLI-CQSNKRWSD-KVICKQKRCPTLAMPANGGFKCV 134
++ +GT + C+ GY G I C N WS + C++K C P NG
Sbjct: 1864 FEFPVGTSLNYECRPGY--FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHIN 1921
Query: 135 DGAYFNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASC--VDMEPPRIKCPSVKE 189
F S Y C+ G+ L G + TC+ +N W + C + EPP P++
Sbjct: 1922 TDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPP----PTISN 1977
Query: 190 RIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPE--GDHKIQYTVYDRAEN 247
N T +G + P G E G+ I T D
Sbjct: 1978 GDFYSNNRT-----------SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVG 2026
Query: 248 KGTCKFRVKVRVKRCGKLNAPE-NGYMKCSSDGDNYGAT--CEFSCIGGYELQGSPARVC 304
+ + +C APE ++ + + T F C G+ + GS C
Sbjct: 2027 VWSSPPPRCISTNKC---TAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQC 2083
Query: 305 QSNLAWSGTEPTCA 318
Q+N W P C+
Sbjct: 2084 QTNGRWGPKLPHCS 2097
Score = 45.8 bits (107), Expect = 8e-05
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 33/252 (13%)
Query: 81 LGTRCDIRCQKGYELHGSSLLIC---QSNKRWSDKV-ICKQKRCPTLAMPANGGF--KCV 134
LG + D C +G++L GSS C W+ V +C+Q CP+ + NG K +
Sbjct: 378 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPL 437
Query: 135 DGAYFNSRCEYYCSP------GYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVK 188
+ F Y C P + L GE T+ C + +G +S P +C +
Sbjct: 438 EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS------PAPRCGILG 491
Query: 189 ERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK 248
A + L ++ +T D G T + + P P + V+ + K
Sbjct: 492 HCQAPDHFLFAKLKTQT-NASDFPIG--TSLKYECRPEYYGRPFSITCLDNLVW--SSPK 546
Query: 249 GTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC--QS 306
CK K C P NG + +D G+ +SC G+ L G + C
Sbjct: 547 DVCK------RKSCKTPPDPVNGMVHVITD-IQVGSRINYSCTTGHRLIGHSSAECILSG 599
Query: 307 NLA-WSGTEPTC 317
N A WS P C
Sbjct: 600 NAAHWSTKPPIC 611
Score = 45.8 bits (107), Expect = 8e-05
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 33/252 (13%)
Query: 81 LGTRCDIRCQKGYELHGSSLLIC---QSNKRWSDKV-ICKQKRCPTLAMPANGGF--KCV 134
LG + D C +G++L GSS C W+ V +C+Q CP+ + NG K +
Sbjct: 828 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPL 887
Query: 135 DGAYFNSRCEYYCSP------GYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVK 188
+ F Y C P + L GE T+ C + +G +S P +C +
Sbjct: 888 EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS------PAPRCGILG 941
Query: 189 ERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK 248
A + L ++ +T D G T + + P P + V+ + K
Sbjct: 942 HCQAPDHFLFAKLKTQT-NASDFPIG--TSLKYECRPEYYGRPFSITCLDNLVW--SSPK 996
Query: 249 GTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC--QS 306
CK K C P NG + +D G+ +SC G+ L G + C
Sbjct: 997 DVCK------RKSCKTPPDPVNGMVHVITD-IQVGSRINYSCTTGHRLIGHSSAECILSG 1049
Query: 307 NLA-WSGTEPTC 317
N A WS P C
Sbjct: 1050 NAAHWSTKPPIC 1061
Score = 45.8 bits (107), Expect = 8e-05
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 33/252 (13%)
Query: 81 LGTRCDIRCQKGYELHGSSLLIC---QSNKRWSDKV-ICKQKRCPTLAMPANGGF--KCV 134
LG + D C +G++L GSS C W+ V +C+Q CP+ + NG K +
Sbjct: 1278 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPL 1337
Query: 135 DGAYFNSRCEYYCSP------GYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVK 188
+ F Y C P + L GE T+ C + +G +S P +C +
Sbjct: 1338 EVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS------PAPRCGILG 1391
Query: 189 ERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK 248
A + L ++ +T D G T + + P P + V+ + K
Sbjct: 1392 HCQAPDHFLFAKLKTQT-NASDFPIG--TSLKYECRPEYYGRPFSITCLDNLVW--SSPK 1446
Query: 249 GTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC--QS 306
CK K C P NG + +D G+ +SC G+ L G + C
Sbjct: 1447 DVCK------RKSCKTPPDPVNGMVHVITD-IQVGSRINYSCTTGHRLIGHSSAECILSG 1499
Query: 307 NLA-WSGTEPTC 317
N A WS P C
Sbjct: 1500 NTAHWSTKPPIC 1511
Score = 45.1 bits (105), Expect = 1e-04
Identities = 38/140 (27%), Positives = 54/140 (38%), Gaps = 9/140 (6%)
Query: 40 EDDEVGY---SHPRYKDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELH 96
+DD+VG PR T C+ +V+ R P + T L RCQ G+ +
Sbjct: 2021 KDDQVGVWSSPPPRCISTNKCTAPEVENA---IRVPGNRSFFT-LTEIIRFRCQPGFVMV 2076
Query: 97 GSSLLICQSNKRWSDKVICKQKRC--PTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLK 154
GS + CQ+N RW K+ + C P + D Y C P Y L+
Sbjct: 2077 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 2136
Query: 155 GERTVTCMDNKAWSGRPASC 174
G ++ C WS C
Sbjct: 2137 GAASLHCTPQGDWSPEAPRC 2156
Score = 44.3 bits (103), Expect = 2e-04
Identities = 67/284 (23%), Positives = 96/284 (33%), Gaps = 61/284 (21%)
Query: 59 PIKVKYGDVYCRAPQGGYYKTALGTRCDIRC--QKGYELHGSSLLICQSNKR----WSDK 112
P + GD + +Y + + RC+ +K +EL G + C SN WS
Sbjct: 619 PPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP 678
Query: 113 VICKQKRCPTLAMPAN--GGFKCVDGAYF---NSRCEYYCSPGYTLKGERTVTCMDNKAW 167
Q P P N G D N E+ C PG+ +KG R V C W
Sbjct: 679 A--PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 736
Query: 168 SGRPASC--VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLP 225
SC V PP + +R + V + G D L+G
Sbjct: 737 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYD----------LRGAA 786
Query: 226 PGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRC---------GKLNAPENGYMKCS 276
P+GD + TC+ VK C G++ P N +
Sbjct: 787 SMRCTPQGDW---------SPAAPTCE------VKSCDDFMGQLLNGRVLFPVNLQL--- 828
Query: 277 SDGDNYGATCEFSCIGGYELQGSPARVC---QSNLAWSGTEPTC 317
GA +F C G++L+GS A C W+ + P C
Sbjct: 829 ------GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 866
Score = 44.3 bits (103), Expect = 2e-04
Identities = 67/284 (23%), Positives = 96/284 (33%), Gaps = 61/284 (21%)
Query: 59 PIKVKYGDVYCRAPQGGYYKTALGTRCDIRC--QKGYELHGSSLLICQSNKR----WSDK 112
P + GD + +Y + + RC+ +K +EL G + C SN WS
Sbjct: 1069 PPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP 1128
Query: 113 VICKQKRCPTLAMPAN--GGFKCVDGAYF---NSRCEYYCSPGYTLKGERTVTCMDNKAW 167
Q P P N G D N E+ C PG+ +KG R V C W
Sbjct: 1129 A--PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 1186
Query: 168 SGRPASC--VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLP 225
SC V PP + +R + V + G D L+G
Sbjct: 1187 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYD----------LRGAA 1236
Query: 226 PGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRC---------GKLNAPENGYMKCS 276
P+GD + TC+ VK C G++ P N +
Sbjct: 1237 SMRCTPQGDW---------SPAAPTCE------VKSCDDFMGQLLNGRVLFPVNLQL--- 1278
Query: 277 SDGDNYGATCEFSCIGGYELQGSPARVC---QSNLAWSGTEPTC 317
GA +F C G++L+GS A C W+ + P C
Sbjct: 1279 ------GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 1316
Score = 43.5 bits (101), Expect = 4e-04
Identities = 39/137 (28%), Positives = 52/137 (37%), Gaps = 15/137 (10%)
Query: 59 PIKVKYGDVYCRAPQGGYYKTALGTRCDI--RCQKGYELHGSSLLICQSNKR----WSDK 112
P + GD + +Y + + RC++ R +K +EL G + C SN WS
Sbjct: 1519 PPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGP 1578
Query: 113 VICKQKRCPTLAMPAN--GGFKCVDGAYF---NSRCEYYCSPGYTLKGERTVTCMDNKAW 167
Q P P N G D N E+ C PG+ +KG R V C W
Sbjct: 1579 A--PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 1636
Query: 168 SGRPASC--VDMEPPRI 182
SC V PP I
Sbjct: 1637 EPELPSCSRVCQPPPEI 1653
Score = 37.4 bits (85), Expect = 0.029
Identities = 34/122 (27%), Positives = 45/122 (36%), Gaps = 24/122 (19%)
Query: 74 GGYYKTAL-GTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGF 131
GG+ L G C GY L G + C WS CK+ C + + NG
Sbjct: 2311 GGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNC-SFPLFMNGIS 2369
Query: 132 KCVD-------GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKC 184
K ++ G Y +CE GYTL+G C + W +PP KC
Sbjct: 2370 KELEMKKVYHYGDYVTLKCE----DGYTLEGSPWSQCQADDRW----------DPPLAKC 2415
Query: 185 PS 186
S
Sbjct: 2416 TS 2417
Score = 33.9 bits (76), Expect = 0.32
Identities = 29/114 (25%), Positives = 43/114 (37%), Gaps = 14/114 (12%)
Query: 77 YKTALGTRCDIRCQKG--YELHGSSLLICQSNKRWSDKVICKQKRCPTLAMPANGGF--K 132
Y + CD +G + L G S + C S+ + + RC L++PA K
Sbjct: 2245 YGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCE-LSVPAACPHPPK 2303
Query: 133 CVDGAYFNSRCEYY---------CSPGYTLKGERTVTCMDNKAWSGRPASCVDM 177
+G Y Y C PGY L G+ + C D WS C ++
Sbjct: 2304 IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV 2357
Score = 32.3 bits (72), Expect = 0.94
Identities = 62/259 (23%), Positives = 90/259 (34%), Gaps = 42/259 (16%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQ---SNKRWSDKV-ICKQKRCPTLAMPANG---GFKC 133
LG + C +G+ L G S C W+ V +C+Q CP NG G
Sbjct: 2181 LGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPF 2240
Query: 134 VD---GAYFNSRCEYYCSPGYT--LKGERTVTCMD----NKAWSGRPASCVDMEPPRIKC 184
D G + C+ + G T L GE ++ C N WS PA ++ P C
Sbjct: 2241 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSS-PAPRCELSVPAA-C 2298
Query: 185 PSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKG--LPPGSNFPEGDHKIQYTVY 242
P +I + + VS P G+ I L G F + ++
Sbjct: 2299 PH-PPKIQNGHYIGGHVSLYLP-------GMTISYICDPGYLLVGKGFIFCTDQGIWSQL 2350
Query: 243 DRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGD--NYGATCEFSCIGGYELQGSP 300
D + C F + + NG K +YG C GY L+GSP
Sbjct: 2351 DHYCKEVNCSFPLFM------------NGISKELEMKKVYHYGDYVTLKCEDGYTLEGSP 2398
Query: 301 ARVCQSNLAWSGTEPTCAA 319
CQ++ W C +
Sbjct: 2399 WSQCQADDRWDPPLAKCTS 2417
>gi|86793036 complement receptor 1 isoform F precursor [Homo
sapiens]
Length = 2039
Score = 58.5 bits (140), Expect = 1e-08
Identities = 71/296 (23%), Positives = 109/296 (36%), Gaps = 58/296 (19%)
Query: 77 YKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVD 135
++ +GT + C+ GY S+ IC N W+ K C++K C P NG +
Sbjct: 61 FEFPIGTYLNYECRPGYSGRPFSI-ICLKNSVWTGAKDRCRRKSCRNPPDPVNGMVHVIK 119
Query: 136 GAYFNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDME---PPRI------- 182
G F S+ +Y C+ GY L G + TC+ D W C + PP I
Sbjct: 120 GIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNETPICDRIPCGLPPTITNGDFIS 179
Query: 183 --------------KC------PSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILK 222
+C V E + EP+ S + G + + K
Sbjct: 180 TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPS--IYCTSNDDQVGIWSGPAPQCIIPNK 237
Query: 223 GLPPG--SNFPEGDHKIQYTVYDRAENKGTCKFRVK-VRVKRCGKLNAPENGYMKCS--- 276
PP + D++ +++ + E + F +K R +C LN E CS
Sbjct: 238 CTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVC 297
Query: 277 -------------SDGDNY--GATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
D DN+ G +SC GY+L+G+ + C WS PTC
Sbjct: 298 QPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 353
Score = 52.8 bits (125), Expect = 7e-07
Identities = 72/292 (24%), Positives = 106/292 (36%), Gaps = 58/292 (19%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDGAYF 139
+GT C+ Y S+ C N WS K +CK+K C T P NG +
Sbjct: 515 IGTSLKYECRPEYYGRPFSIT-CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 573
Query: 140 NSRCEYYCSPGYTLKGERTVTCM--DNKA-WSGRPASCVDME---PPRI----------- 182
SR Y C+ G+ L G + C+ N A WS +P C + PP I
Sbjct: 574 GSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 633
Query: 183 ----------KC------PSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPP 226
+C V E + EP+ S + G + + K PP
Sbjct: 634 NFHYGSVVTYRCNPGSGGRKVFELVGEPS--IYCTSNDDQVGIWSGPAPQCIIPNKCTPP 691
Query: 227 G--SNFPEGDHKIQYTVYDRAENKGTCKFRVK-VRVKRCGKLNAPENGYMKCS------- 276
+ D++ +++ + E + F +K R +C LN E CS
Sbjct: 692 NVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPP 751
Query: 277 ---------SDGDNY--GATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTC 317
D DN+ G +SC GY+L+G+ + C WS PTC
Sbjct: 752 DVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWSPAAPTC 803
Score = 52.0 bits (123), Expect = 1e-06
Identities = 70/292 (23%), Positives = 107/292 (36%), Gaps = 56/292 (19%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGFKCVDGAYF 139
+GT C+ Y S+ C N WS K +CK+K C T P NG +
Sbjct: 965 IGTSLKYECRPEYYGRPFSIT-CLDNLVWSSPKDVCKRKSCKTPPDPVNGMVHVITDIQV 1023
Query: 140 NSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASCVDME---PPRIK----CPSVKE 189
SR Y C+ G+ L G + C+ + WS +P C + PP I + +E
Sbjct: 1024 GSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQRIPCGLPPTIANGDFISTNRE 1083
Query: 190 RIAEPNKLTVRVSWETPEGR----------------DTADGILTDVILKGLPPGSNFPE- 232
+ +T R + + GR D GI + + + P P
Sbjct: 1084 NFHYGSVVTYRCNLGS-RGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPN 1142
Query: 233 -------GDHKIQYTVYDRAENKGTCKFRVK-VRVKRCGKLNAPENGYMKCS-------- 276
D++ +++ + E + F +K R +C LN E CS
Sbjct: 1143 VENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPE 1202
Query: 277 --------SDGDNY--GATCEFSCIGGYELQGSPARVCQSNLAWSGTEPTCA 318
S DN+ G +SC GY+L+G+ + C WS P CA
Sbjct: 1203 ILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDWSPEAPRCA 1254
Score = 47.8 bits (112), Expect = 2e-05
Identities = 74/309 (23%), Positives = 106/309 (34%), Gaps = 65/309 (21%)
Query: 34 SGDSPLEDDEVGYSHPRYKDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRC--QK 91
SGD+ + D+E P P P + GD + +Y + + RC+ +K
Sbjct: 148 SGDTVIWDNET----PICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRK 203
Query: 92 GYELHGSSLLICQSNKR----WSDKVICKQKRCPTLAMPAN--GGFKCVDGAYF---NSR 142
+EL G + C SN WS Q P P N G D N
Sbjct: 204 VFELVGEPSIYCTSNDDQVGIWSGPA--PQCIIPNKCTPPNVENGILVSDNRSLFSLNEV 261
Query: 143 CEYYCSPGYTLKGERTVTCMDNKAWSGRPASC--VDMEPPRIKCPSVKERIAEPNKLTVR 200
E+ C PG+ +KG R V C W SC V PP + +R +
Sbjct: 262 VEFRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQE 321
Query: 201 VSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVK 260
V + G D L+G P+GD + TC+ VK
Sbjct: 322 VFYSCEPGYD----------LRGAASMRCTPQGDW---------SPAAPTCE------VK 356
Query: 261 RC---------GKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC---QSNL 308
C G++ P N + GA +F C G++L+GS A C
Sbjct: 357 SCDDFMGQLLNGRVLFPVNLQL---------GAKVDFVCDEGFQLKGSSASYCVLAGMES 407
Query: 309 AWSGTEPTC 317
W+ + P C
Sbjct: 408 LWNSSVPVC 416
Score = 47.8 bits (112), Expect = 2e-05
Identities = 60/260 (23%), Positives = 92/260 (35%), Gaps = 48/260 (18%)
Query: 79 TALGTRCDIRCQKGYELHGS---SLLICQSNKRWSDKV-ICKQKRCPTLAMPANGGFKCV 134
T G+ + C +G+ L GS + L+ +N W K IC+ C +NG F
Sbjct: 1474 TQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSN 1533
Query: 135 DGAYFNSRC--EYYCSPG------YTLKGERTVTCMDNK----AWSGRPASCVDMEPPRI 182
+ F++ Y C G + L GER++ C WS P C+ +
Sbjct: 1534 NRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTN--KC 1591
Query: 183 KCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVY 242
P V+ I P + LT++I PG G H +Q
Sbjct: 1592 TAPEVENAIRVPGNRSFFT--------------LTEIIRFRCQPGFVMV-GSHTVQCQTN 1636
Query: 243 DRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCS---SDGDNY--GATCEFSCIGGYELQ 297
R K + C ++ P + S DN+ G +SC Y+L+
Sbjct: 1637 GRWGPK----------LPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 1686
Query: 298 GSPARVCQSNLAWSGTEPTC 317
G+ + C WS P C
Sbjct: 1687 GAASLHCTPQGDWSPEAPRC 1706
Score = 46.6 bits (109), Expect = 5e-05
Identities = 59/254 (23%), Positives = 90/254 (35%), Gaps = 32/254 (12%)
Query: 77 YKTALGTRCDIRCQKGYELHGSSLLI-CQSNKRWSD-KVICKQKRCPTLAMPANGGFKCV 134
++ +GT + C+ GY G I C N WS + C++K C P NG
Sbjct: 1414 FEFPVGTSLNYECRPGY--FGKMFSISCLENLVWSSVEDNCRRKSCGPPPEPFNGMVHIN 1471
Query: 135 DGAYFNSRCEYYCSPGYTLKGERTVTCM---DNKAWSGRPASC--VDMEPPRIKCPSVKE 189
F S Y C+ G+ L G + TC+ +N W + C + EPP P++
Sbjct: 1472 TDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPP----PTISN 1527
Query: 190 RIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPE--GDHKIQYTVYDRAEN 247
N T +G + P G E G+ I T D
Sbjct: 1528 GDFYSNNRT-----------SFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVG 1576
Query: 248 KGTCKFRVKVRVKRCGKLNAPE-NGYMKCSSDGDNYGAT--CEFSCIGGYELQGSPARVC 304
+ + +C APE ++ + + T F C G+ + GS C
Sbjct: 1577 VWSSPPPRCISTNKC---TAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTVQC 1633
Query: 305 QSNLAWSGTEPTCA 318
Q+N W P C+
Sbjct: 1634 QTNGRWGPKLPHCS 1647
Score = 45.8 bits (107), Expect = 8e-05
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 33/252 (13%)
Query: 81 LGTRCDIRCQKGYELHGSSLLIC---QSNKRWSDKV-ICKQKRCPTLAMPANGGF--KCV 134
LG + D C +G++L GSS C W+ V +C+Q CP+ + NG K +
Sbjct: 378 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPL 437
Query: 135 DGAYFNSRCEYYCSP------GYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVK 188
+ F Y C P + L GE T+ C + +G +S P +C +
Sbjct: 438 EVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS------PAPRCGILG 491
Query: 189 ERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK 248
A + L ++ +T D G T + + P P + V+ + K
Sbjct: 492 HCQAPDHFLFAKLKTQT-NASDFPIG--TSLKYECRPEYYGRPFSITCLDNLVW--SSPK 546
Query: 249 GTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC--QS 306
CK K C P NG + +D G+ +SC G+ L G + C
Sbjct: 547 DVCK------RKSCKTPPDPVNGMVHVITD-IQVGSRINYSCTTGHRLIGHSSAECILSG 599
Query: 307 NLA-WSGTEPTC 317
N A WS P C
Sbjct: 600 NAAHWSTKPPIC 611
Score = 45.8 bits (107), Expect = 8e-05
Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 33/252 (13%)
Query: 81 LGTRCDIRCQKGYELHGSSLLIC---QSNKRWSDKV-ICKQKRCPTLAMPANGGF--KCV 134
LG + D C +G++L GSS C W+ V +C+Q CP+ + NG K +
Sbjct: 828 LGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCEQIFCPSPPVIPNGRHTGKPL 887
Query: 135 DGAYFNSRCEYYCSP------GYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVK 188
+ F Y C P + L GE T+ C + +G +S P +C +
Sbjct: 888 EVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSDPQGNGVWSS------PAPRCGILG 941
Query: 189 ERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENK 248
A + L ++ +T D G T + + P P + V+ + K
Sbjct: 942 HCQAPDHFLFAKLKTQT-NASDFPIG--TSLKYECRPEYYGRPFSITCLDNLVW--SSPK 996
Query: 249 GTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVC--QS 306
CK K C P NG + +D G+ +SC G+ L G + C
Sbjct: 997 DVCK------RKSCKTPPDPVNGMVHVITD-IQVGSRINYSCTTGHRLIGHSSAECILSG 1049
Query: 307 NLA-WSGTEPTC 317
N A WS P C
Sbjct: 1050 NTAHWSTKPPIC 1061
Score = 45.1 bits (105), Expect = 1e-04
Identities = 38/140 (27%), Positives = 54/140 (38%), Gaps = 9/140 (6%)
Query: 40 EDDEVGY---SHPRYKDTPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELH 96
+DD+VG PR T C+ +V+ R P + T L RCQ G+ +
Sbjct: 1571 KDDQVGVWSSPPPRCISTNKCTAPEVENA---IRVPGNRSFFT-LTEIIRFRCQPGFVMV 1626
Query: 97 GSSLLICQSNKRWSDKVICKQKRC--PTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLK 154
GS + CQ+N RW K+ + C P + D Y C P Y L+
Sbjct: 1627 GSHTVQCQTNGRWGPKLPHCSRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLR 1686
Query: 155 GERTVTCMDNKAWSGRPASC 174
G ++ C WS C
Sbjct: 1687 GAASLHCTPQGDWSPEAPRC 1706
Score = 44.3 bits (103), Expect = 2e-04
Identities = 67/284 (23%), Positives = 96/284 (33%), Gaps = 61/284 (21%)
Query: 59 PIKVKYGDVYCRAPQGGYYKTALGTRCDIRC--QKGYELHGSSLLICQSNKR----WSDK 112
P + GD + +Y + + RC+ +K +EL G + C SN WS
Sbjct: 619 PPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGP 678
Query: 113 VICKQKRCPTLAMPAN--GGFKCVDGAYF---NSRCEYYCSPGYTLKGERTVTCMDNKAW 167
Q P P N G D N E+ C PG+ +KG R V C W
Sbjct: 679 A--PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 736
Query: 168 SGRPASC--VDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLP 225
SC V PP + +R + V + G D L+G
Sbjct: 737 EPELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYD----------LRGAA 786
Query: 226 PGSNFPEGDHKIQYTVYDRAENKGTCKFRVKVRVKRC---------GKLNAPENGYMKCS 276
P+GD + TC+ VK C G++ P N +
Sbjct: 787 SMRCTPQGDW---------SPAAPTCE------VKSCDDFMGQLLNGRVLFPVNLQL--- 828
Query: 277 SDGDNYGATCEFSCIGGYELQGSPARVC---QSNLAWSGTEPTC 317
GA +F C G++L+GS A C W+ + P C
Sbjct: 829 ------GAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVC 866
Score = 43.5 bits (101), Expect = 4e-04
Identities = 39/137 (28%), Positives = 52/137 (37%), Gaps = 15/137 (10%)
Query: 59 PIKVKYGDVYCRAPQGGYYKTALGTRCDI--RCQKGYELHGSSLLICQSNKR----WSDK 112
P + GD + +Y + + RC++ R +K +EL G + C SN WS
Sbjct: 1069 PPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGP 1128
Query: 113 VICKQKRCPTLAMPAN--GGFKCVDGAYF---NSRCEYYCSPGYTLKGERTVTCMDNKAW 167
Q P P N G D N E+ C PG+ +KG R V C W
Sbjct: 1129 A--PQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNKW 1186
Query: 168 SGRPASC--VDMEPPRI 182
SC V PP I
Sbjct: 1187 EPELPSCSRVCQPPPEI 1203
Score = 37.4 bits (85), Expect = 0.029
Identities = 34/122 (27%), Positives = 45/122 (36%), Gaps = 24/122 (19%)
Query: 74 GGYYKTAL-GTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKQKRCPTLAMPANGGF 131
GG+ L G C GY L G + C WS CK+ C + + NG
Sbjct: 1861 GGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNC-SFPLFMNGIS 1919
Query: 132 KCVD-------GAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKC 184
K ++ G Y +CE GYTL+G C + W +PP KC
Sbjct: 1920 KELEMKKVYHYGDYVTLKCE----DGYTLEGSPWSQCQADDRW----------DPPLAKC 1965
Query: 185 PS 186
S
Sbjct: 1966 TS 1967
Score = 33.9 bits (76), Expect = 0.32
Identities = 29/114 (25%), Positives = 43/114 (37%), Gaps = 14/114 (12%)
Query: 77 YKTALGTRCDIRCQKG--YELHGSSLLICQSNKRWSDKVICKQKRCPTLAMPANGGF--K 132
Y + CD +G + L G S + C S+ + + RC L++PA K
Sbjct: 1795 YGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSSPAPRCE-LSVPAACPHPPK 1853
Query: 133 CVDGAYFNSRCEYY---------CSPGYTLKGERTVTCMDNKAWSGRPASCVDM 177
+G Y Y C PGY L G+ + C D WS C ++
Sbjct: 1854 IQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEV 1907
Score = 32.3 bits (72), Expect = 0.94
Identities = 62/259 (23%), Positives = 90/259 (34%), Gaps = 42/259 (16%)
Query: 81 LGTRCDIRCQKGYELHGSSLLICQ---SNKRWSDKV-ICKQKRCPTLAMPANG---GFKC 133
LG + C +G+ L G S C W+ V +C+Q CP NG G
Sbjct: 1731 LGAKVSFVCDEGFRLKGRSASHCVLAGMKALWNSSVPVCEQIFCPNPPAILNGRHTGTPF 1790
Query: 134 VD---GAYFNSRCEYYCSPGYT--LKGERTVTCMD----NKAWSGRPASCVDMEPPRIKC 184
D G + C+ + G T L GE ++ C N WS PA ++ P C
Sbjct: 1791 GDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSDPQGNGVWSS-PAPRCELSVPAA-C 1848
Query: 185 PSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKG--LPPGSNFPEGDHKIQYTVY 242
P +I + + VS P G+ I L G F + ++
Sbjct: 1849 PH-PPKIQNGHYIGGHVSLYLP-------GMTISYICDPGYLLVGKGFIFCTDQGIWSQL 1900
Query: 243 DRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGD--NYGATCEFSCIGGYELQGSP 300
D + C F + + NG K +YG C GY L+GSP
Sbjct: 1901 DHYCKEVNCSFPLFM------------NGISKELEMKKVYHYGDYVTLKCEDGYTLEGSP 1948
Query: 301 ARVCQSNLAWSGTEPTCAA 319
CQ++ W C +
Sbjct: 1949 WSQCQADDRWDPPLAKCTS 1967
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,572,300
Number of Sequences: 37866
Number of extensions: 1045079
Number of successful extensions: 3428
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 2218
Number of HSP's gapped (non-prelim): 866
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.