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Search of human proteins with 5453872
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5453872 platelet-derived growth factor receptor-like protein
[Homo sapiens]
(375 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5453872 platelet-derived growth factor receptor-like protein ... 761 0.0
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [... 92 1e-18
gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor [... 92 1e-18
gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor [... 92 1e-18
gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor [... 92 1e-18
gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 81 1e-15
gi|4505683 platelet-derived growth factor receptor beta precurso... 70 3e-12
gi|5453870 platelet-derived growth factor receptor alpha precurs... 70 4e-12
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [... 69 7e-12
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [... 69 7e-12
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge... 62 1e-09
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene... 62 1e-09
gi|110349719 titin isoform N2-A [Homo sapiens] 54 2e-07
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 52 1e-06
gi|88979855 PREDICTED: similar to v-kit Hardy-Zuckerman 4 feline... 51 1e-06
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 51 2e-06
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 51 2e-06
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 51 2e-06
gi|27262659 colony stimulating factor 1 receptor precursor [Homo... 49 1e-05
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 45 1e-04
gi|139948432 adlican [Homo sapiens] 43 5e-04
gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens] 42 0.001
gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 42 0.001
gi|144226847 obscurin-like 1 [Homo sapiens] 40 0.003
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 40 0.003
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 40 0.003
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 40 0.003
gi|118572606 hemicentin 1 [Homo sapiens] 39 0.006
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 39 0.006
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 39 0.008
>gi|5453872 platelet-derived growth factor receptor-like protein
[Homo sapiens]
Length = 375
Score = 761 bits (1966), Expect = 0.0
Identities = 375/375 (100%), Positives = 375/375 (100%)
Query: 1 MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANS 60
MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANS
Sbjct: 1 MKVWLLLGLLLVHEALEDVTGQHLPKNKRPKEPGENRIKPTNKKVKPKIPKMKDRDSANS 60
Query: 61 APKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVK 120
APKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVK
Sbjct: 61 APKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVK 120
Query: 121 QNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSY 180
QNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSY
Sbjct: 121 QNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSY 180
Query: 181 FDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEH 240
FDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEH
Sbjct: 181 FDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEH 240
Query: 241 QGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPD 300
QGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPD
Sbjct: 241 QGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPD 300
Query: 301 VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQ 360
VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQ
Sbjct: 301 VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQ 360
Query: 361 NLQGQTTVATTVEFS 375
NLQGQTTVATTVEFS
Sbjct: 361 NLQGQTTVATTVEFS 375
>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor
[Homo sapiens]
Length = 1338
Score = 91.7 bits (226), Expect = 1e-18
Identities = 78/298 (26%), Positives = 141/298 (47%), Gaps = 29/298 (9%)
Query: 88 AGQTVELRCKGSRIG-WSYPAYLDTFKDSRLSVKQNE--RYGQ-----LTLVNSTSADTG 139
AGQT+ L+C+G WS P + + RLS+ ++ R G+ LTL + + TG
Sbjct: 45 AGQTLHLQCRGEAAHKWSLPEMVSK-ESERLSITKSACGRNGKQFCSTLTLNTAQANHTG 103
Query: 140 EFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYF-DVVYLNPDRQAVVPCRV 198
+SC + + +K E ++ + YIF ++ G FV S +++++ R+ V+PCRV
Sbjct: 104 FYSC--KYLAVPTSKKKETES-AIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRV 160
Query: 199 TVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGR----S 254
T + VTL ++FP + +G I++D ++GF+ + G++ C A G +
Sbjct: 161 TSPNITVTL-KKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN 219
Query: 255 QISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKD 314
++ + + V P K+ G + + CT + V+ TW +P +K+
Sbjct: 220 YLTHRQTNTIIDVQISTPRPV------KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKN 273
Query: 315 ERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+R R I + H I SV+T++ + D G Y C ++ +V T+V
Sbjct: 274 KR----ASVRRRIDQSNSH-ANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
>gi|229892220 fms-related tyrosine kinase 1 isoform 2 precursor
[Homo sapiens]
Length = 687
Score = 91.7 bits (226), Expect = 1e-18
Identities = 78/298 (26%), Positives = 141/298 (47%), Gaps = 29/298 (9%)
Query: 88 AGQTVELRCKGSRIG-WSYPAYLDTFKDSRLSVKQNE--RYGQ-----LTLVNSTSADTG 139
AGQT+ L+C+G WS P + + RLS+ ++ R G+ LTL + + TG
Sbjct: 45 AGQTLHLQCRGEAAHKWSLPEMVSK-ESERLSITKSACGRNGKQFCSTLTLNTAQANHTG 103
Query: 140 EFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYF-DVVYLNPDRQAVVPCRV 198
+SC + + +K E ++ + YIF ++ G FV S +++++ R+ V+PCRV
Sbjct: 104 FYSC--KYLAVPTSKKKETES-AIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRV 160
Query: 199 TVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGR----S 254
T + VTL ++FP + +G I++D ++GF+ + G++ C A G +
Sbjct: 161 TSPNITVTL-KKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN 219
Query: 255 QISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKD 314
++ + + V P K+ G + + CT + V+ TW +P +K+
Sbjct: 220 YLTHRQTNTIIDVQISTPRPV------KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKN 273
Query: 315 ERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+R R I + H I SV+T++ + D G Y C ++ +V T+V
Sbjct: 274 KR----ASVRRRIDQSNSH-ANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
>gi|229892302 fms-related tyrosine kinase 1 isoform 4 precursor
[Homo sapiens]
Length = 541
Score = 91.7 bits (226), Expect = 1e-18
Identities = 78/298 (26%), Positives = 141/298 (47%), Gaps = 29/298 (9%)
Query: 88 AGQTVELRCKGSRIG-WSYPAYLDTFKDSRLSVKQNE--RYGQ-----LTLVNSTSADTG 139
AGQT+ L+C+G WS P + + RLS+ ++ R G+ LTL + + TG
Sbjct: 45 AGQTLHLQCRGEAAHKWSLPEMVSK-ESERLSITKSACGRNGKQFCSTLTLNTAQANHTG 103
Query: 140 EFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYF-DVVYLNPDRQAVVPCRV 198
+SC + + +K E ++ + YIF ++ G FV S +++++ R+ V+PCRV
Sbjct: 104 FYSC--KYLAVPTSKKKETES-AIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRV 160
Query: 199 TVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGR----S 254
T + VTL ++FP + +G I++D ++GF+ + G++ C A G +
Sbjct: 161 TSPNITVTL-KKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN 219
Query: 255 QISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKD 314
++ + + V P K+ G + + CT + V+ TW +P +K+
Sbjct: 220 YLTHRQTNTIIDVQISTPRPV------KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKN 273
Query: 315 ERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+R R I + H I SV+T++ + D G Y C ++ +V T+V
Sbjct: 274 KR----ASVRRRIDQSNSH-ANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
>gi|229892300 fms-related tyrosine kinase 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 91.7 bits (226), Expect = 1e-18
Identities = 78/298 (26%), Positives = 141/298 (47%), Gaps = 29/298 (9%)
Query: 88 AGQTVELRCKGSRIG-WSYPAYLDTFKDSRLSVKQNE--RYGQ-----LTLVNSTSADTG 139
AGQT+ L+C+G WS P + + RLS+ ++ R G+ LTL + + TG
Sbjct: 45 AGQTLHLQCRGEAAHKWSLPEMVSK-ESERLSITKSACGRNGKQFCSTLTLNTAQANHTG 103
Query: 140 EFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYF-DVVYLNPDRQAVVPCRV 198
+SC + + +K E ++ + YIF ++ G FV S +++++ R+ V+PCRV
Sbjct: 104 FYSC--KYLAVPTSKKKETES-AIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRV 160
Query: 199 TVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGR----S 254
T + VTL ++FP + +G I++D ++GF+ + G++ C A G +
Sbjct: 161 TSPNITVTL-KKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTN 219
Query: 255 QISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKD 314
++ + + V P K+ G + + CT + V+ TW +P +K+
Sbjct: 220 YLTHRQTNTIIDVQISTPRPV------KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKN 273
Query: 315 ERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+R R I + H I SV+T++ + D G Y C ++ +V T+V
Sbjct: 274 KR----ASVRRRIDQSNSH-ANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSV 326
>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
Length = 1356
Score = 81.3 bits (199), Expect = 1e-15
Identities = 70/304 (23%), Positives = 131/304 (43%), Gaps = 35/304 (11%)
Query: 72 LDKGRFQKPAATLSLLAGQTVELRCKGSR-IGWSYPAYLDTFKDSRLSVKQNER---YGQ 127
LD R L++ A T+++ C+G R + W +P + + R+ V +
Sbjct: 29 LDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNN-QSGSEQRVEVTECSDGLFCKT 87
Query: 128 LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPS-YFDVVYL 186
LT+ DTG + C+ ++ Y++ + F+ S S VVY+
Sbjct: 88 LTIPKVIGNDTGAYKCFY---------RETDLASVIYVYVQDYRSPFIASVSDQHGVVYI 138
Query: 187 --NPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVV 244
N ++ V+PC ++ + V+L +P K +G I +D K+GF + G+V
Sbjct: 139 TENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMV 198
Query: 245 YCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSN---KVKSGDDISVLCTVLGEPDV 301
+C A+ S S+ +Y+ V G ++ S + ++ G+ + + CT E +V
Sbjct: 199 FCEAKINDESYQSI----MYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNV 254
Query: 302 EVEFTWIFPGQKDERPVTIQDTWRLIHRGL----GHTTRISQSVITVEDFETIDAGYYIC 357
++F W +P K + +L++R L G + S +T++ D G Y C
Sbjct: 255 GIDFNWEYPSSKHQHK-------KLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTC 307
Query: 358 TAQN 361
A +
Sbjct: 308 AASS 311
>gi|4505683 platelet-derived growth factor receptor beta precursor
[Homo sapiens]
Length = 1106
Score = 70.1 bits (170), Expect = 3e-12
Identities = 75/284 (26%), Positives = 117/284 (41%), Gaps = 36/284 (12%)
Query: 80 PAATLSLLAGQTVELRCKGS------RIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNS 133
P L L T L C GS R+ P + +D S LTL N
Sbjct: 38 PGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFS-------SVLTLTNL 90
Query: 134 TSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAV 193
T DTGE+ C G DE K YIF + F+P+ + ++L +
Sbjct: 91 TGLDTGEYFCTHNDSRGL--ETDERKR--LYIFVPDPTVGFLPNDAEELFIFLTEITEIT 146
Query: 194 VPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGR 253
+PCRVT VTLH + +P + YD +RGF + + C+ G R
Sbjct: 147 IPCRVTDPQLVVTLHEKKGDVALP-----VPYDHQRGFSGIFEDRSY----ICKTTIGDR 197
Query: 254 SQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQK 313
S Y + + V S + ++ A V+ G++I+++C V+G + V F W +P ++
Sbjct: 198 EVDSDAYYVYRLQVSS--INVSVNAVQTVVRQGENITLMCIVIG--NEVVNFEWTYPRKE 253
Query: 314 DERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYIC 357
R V + L + + R S++ + E D+G Y C
Sbjct: 254 SGRLVEPVTDFLL---DMPYHIR---SILHIPSAELEDSGTYTC 291
>gi|5453870 platelet-derived growth factor receptor alpha precursor
[Homo sapiens]
Length = 1089
Score = 69.7 bits (169), Expect = 4e-12
Identities = 66/271 (24%), Positives = 116/271 (42%), Gaps = 28/271 (10%)
Query: 94 LRCKG-SRIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSAD---TGEFSCWVQLCS 149
LRC G S + W YP + D + ++N +T++ +SA TG ++C+
Sbjct: 47 LRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQ 106
Query: 150 GYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHR 209
++E + YI+ + FVP +V + D A++PCR T VTLH
Sbjct: 107 ---TEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHN 163
Query: 210 EFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPS 269
+PA+ YD ++GF + G C A G+ ++ + +Y +
Sbjct: 164 S--EGVVPAS-----YDSRQGF----NGTFTVGPYICEATVKGKKFQTIPFN-VYALKAT 211
Query: 270 GPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHR 329
+ A KSG+ I V C V V+++ W +PG+ + +T+ + ++
Sbjct: 212 SELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQ--WTYPGEVKGKGITMLEEIKVPSI 269
Query: 330 GLGHTTRISQSVITVEDFETIDAGYYICTAQ 360
L +T +TV + D+G Y C A+
Sbjct: 270 KLVYT-------LTVPEATVKDSGDYECAAR 293
>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor
[Homo sapiens]
Length = 1363
Score = 68.9 bits (167), Expect = 7e-12
Identities = 70/287 (24%), Positives = 129/287 (44%), Gaps = 30/287 (10%)
Query: 89 GQTVELRCKGSR-IGWSYPAYLDT----FKDSRLS--VKQNER-----YGQLTLVNSTSA 136
G ++ + C+G + W++P + KDS + V+ E Y ++ L++ A
Sbjct: 44 GDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHA 103
Query: 137 -DTGEFSCWVQLCSGYICRKDEAKTG-STYIFFTEKGELFVPSPSYFDVVYLNPDRQAVV 194
DTG + C+ + YI + E T S+Y+F + + F+ P D + +N V
Sbjct: 104 NDTGSYVCYYK----YIKARIEGTTAASSYVFVRDFEQPFINKP---DTLLVNRKDAMWV 156
Query: 195 PCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRS 254
PC V++ VTL + + + +G ++V+D +RG + P + C G +
Sbjct: 157 PCLVSIPGLNVTLRSQ--SSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQD 214
Query: 255 QISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKD 314
+S + L+++ + S ++ G+ + + CTV E + V F W +PG++
Sbjct: 215 FLSNPF-LVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQA 273
Query: 315 ERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQN 361
ER W R T +S S++T+ + D G Y+C A N
Sbjct: 274 ER-----GKWVPERRSQQTHTELS-SILTIHNVSQHDLGSYVCKANN 314
Score = 33.5 bits (75), Expect = 0.32
Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 15/111 (13%)
Query: 271 PPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVT----IQDTWRL 326
PP+ I S+ + +GD +S+ C G+ +E W +PG + E P T +DT +
Sbjct: 29 PPTLNITEESHVIDTGDSLSISCR--GQHPLE----WAWPGAQ-EAPATGDKDSEDT-GV 80
Query: 327 IHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQ---TTVATTVEF 374
+ G R V+ + + D G Y+C + ++ + TT A++ F
Sbjct: 81 VRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVF 131
>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor
[Homo sapiens]
Length = 1298
Score = 68.9 bits (167), Expect = 7e-12
Identities = 70/287 (24%), Positives = 129/287 (44%), Gaps = 30/287 (10%)
Query: 89 GQTVELRCKGSR-IGWSYPAYLDT----FKDSRLS--VKQNER-----YGQLTLVNSTSA 136
G ++ + C+G + W++P + KDS + V+ E Y ++ L++ A
Sbjct: 44 GDSLSISCRGQHPLEWAWPGAQEAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHA 103
Query: 137 -DTGEFSCWVQLCSGYICRKDEAKTG-STYIFFTEKGELFVPSPSYFDVVYLNPDRQAVV 194
DTG + C+ + YI + E T S+Y+F + + F+ P D + +N V
Sbjct: 104 NDTGSYVCYYK----YIKARIEGTTAASSYVFVRDFEQPFINKP---DTLLVNRKDAMWV 156
Query: 195 PCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRS 254
PC V++ VTL + + + +G ++V+D +RG + P + C G +
Sbjct: 157 PCLVSIPGLNVTLRSQ--SSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQD 214
Query: 255 QISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKD 314
+S + L+++ + S ++ G+ + + CTV E + V F W +PG++
Sbjct: 215 FLSNPF-LVHITGNELYDIQLLPRKSLELLVGEKLVLNCTVWAEFNSGVTFDWDYPGKQA 273
Query: 315 ERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQN 361
ER W R T +S S++T+ + D G Y+C A N
Sbjct: 274 ER-----GKWVPERRSQQTHTELS-SILTIHNVSQHDLGSYVCKANN 314
Score = 33.5 bits (75), Expect = 0.32
Identities = 29/111 (26%), Positives = 52/111 (46%), Gaps = 15/111 (13%)
Query: 271 PPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVT----IQDTWRL 326
PP+ I S+ + +GD +S+ C G+ +E W +PG + E P T +DT +
Sbjct: 29 PPTLNITEESHVIDTGDSLSISCR--GQHPLE----WAWPGAQ-EAPATGDKDSEDT-GV 80
Query: 327 IHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQ---TTVATTVEF 374
+ G R V+ + + D G Y+C + ++ + TT A++ F
Sbjct: 81 VRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVF 131
>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 2 precursor [Homo sapiens]
Length = 972
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/224 (22%), Positives = 95/224 (42%), Gaps = 13/224 (5%)
Query: 151 YICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHRE 210
Y C + S Y+F + +LF+ S +Y D +V C +T +
Sbjct: 95 YTCTNKHGLSNSIYVFVRDPAKLFLVDRS----LYGKEDNDTLVRCPLTDPEVTNYSLKG 150
Query: 211 FPAKEIPANGTDIVYDMKRGFVYLQ-PHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPS 269
K +P + + D K G + + H+ ++C + G+S +S K+ L
Sbjct: 151 CQGKPLPKD-LRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFK 209
Query: 270 GPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHR 329
P ++ +S ++ G++ +V CT+ + V TW +++ +Q+ + H
Sbjct: 210 AVPVVSVSKASYLLREGEEFTVTCTIK-DVSSSVYSTW----KRENSQTKLQEKYNSWHH 264
Query: 330 GLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
G + R Q+ +T+ D+G ++C A N G V TT+E
Sbjct: 265 GDFNYER--QATLTISSARVNDSGVFMCYANNTFGSANVTTTLE 306
>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
homolog isoform 1 precursor [Homo sapiens]
Length = 976
Score = 61.6 bits (148), Expect = 1e-09
Identities = 50/224 (22%), Positives = 95/224 (42%), Gaps = 13/224 (5%)
Query: 151 YICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHRE 210
Y C + S Y+F + +LF+ S +Y D +V C +T +
Sbjct: 95 YTCTNKHGLSNSIYVFVRDPAKLFLVDRS----LYGKEDNDTLVRCPLTDPEVTNYSLKG 150
Query: 211 FPAKEIPANGTDIVYDMKRGFVYLQ-PHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPS 269
K +P + + D K G + + H+ ++C + G+S +S K+ L
Sbjct: 151 CQGKPLPKD-LRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFK 209
Query: 270 GPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHR 329
P ++ +S ++ G++ +V CT+ + V TW +++ +Q+ + H
Sbjct: 210 AVPVVSVSKASYLLREGEEFTVTCTIK-DVSSSVYSTW----KRENSQTKLQEKYNSWHH 264
Query: 330 GLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
G + R Q+ +T+ D+G ++C A N G V TT+E
Sbjct: 265 GDFNYER--QATLTISSARVNDSGVFMCYANNTFGSANVTTTLE 306
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 54.3 bits (129), Expect = 2e-07
Identities = 78/320 (24%), Positives = 125/320 (39%), Gaps = 52/320 (16%)
Query: 69 MQVLDKG---RFQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSR---LSVKQ- 121
++VLD+ F K + + G ++ + CK + S P FKD + S K
Sbjct: 5228 LRVLDQNIPPSFTKKLTKMDKVLGSSIHMECK---VSGSLPISAQWFKDGKEISTSAKYR 5284
Query: 122 ---NERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSP 178
+ER L + N DT ++C V +G D+A +G L V P
Sbjct: 5285 LVCHERSVSLEVNNLELEDTANYTCKVSNVAG-----DDACSGI----------LTVKEP 5329
Query: 179 SYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHS 238
F V P RQ +P A + F K + ++V K F+ L+ +
Sbjct: 5330 PSFLV---KPGRQQAIPDSTVEFKAILKGTPPFKIKWFK-DDVELVSGPKC-FIGLEGST 5384
Query: 239 EHQGVVYCRAEAGGRSQISVKYQL------LYVAVPSGPPSTTILASSNKVKSGDDISVL 292
+ A G+ V + + V P L +S VK+GD +
Sbjct: 5385 SFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLE 5444
Query: 293 CTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDA 352
C + G P++ V W ++E + D +R+ T S +VI + + T D+
Sbjct: 5445 CKIAGSPEIRV--VWF----RNEHELPASDKYRM-------TFIDSVAVIQMNNLSTEDS 5491
Query: 353 GYYICTAQNLQGQTTVATTV 372
G +IC AQN G T+ +T V
Sbjct: 5492 GDFICEAQNPAGSTSCSTKV 5511
Score = 42.0 bits (97), Expect = 9e-04
Identities = 61/283 (21%), Positives = 106/283 (37%), Gaps = 42/283 (14%)
Query: 101 IGWSYPAYLDTFKDSR-------LSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYIC 153
+G + P + FKD++ SV +++ L L + + D+G + C +
Sbjct: 4791 VGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLS------- 4843
Query: 154 RKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPA 213
D S F ++ F+ PS V+ L + C++T + K+ +
Sbjct: 4844 -NDVGTATSKATLFVKEPPQFIKKPS--PVLVLRNGQSTTFECQITG-TPKIRVSWYLDG 4899
Query: 214 KEIPA---NGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEA-GGRSQISVKYQLLYVAVPS 269
EI A +G + D F E+ G C A G + S++ ++
Sbjct: 4900 NEITAIQKHGISFI-DGLATFQISGARVENSGTYVCEARNDAGTASCSIELKV------K 4952
Query: 270 GPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHR 329
PP+ +V D+ + C V G P EV TW+ K+ R + + L
Sbjct: 4953 EPPTFIRELKPVEVVKYSDVELECEVTGTPPFEV--TWL----KNNREIRSSKKYTL--- 5003
Query: 330 GLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
T R+S + + + D G Y C N G + +T V
Sbjct: 5004 ----TDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRV 5042
Score = 41.6 bits (96), Expect = 0.001
Identities = 73/316 (23%), Positives = 117/316 (37%), Gaps = 63/316 (19%)
Query: 77 FQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERY--------GQL 128
F KP + + T L CK I S P + FKD + + ++RY L
Sbjct: 4115 FTKPLRNVDSVVNGTCRLDCK---IAGSLPMRVSWFKDGK-EIAASDRYRIAFVEGTASL 4170
Query: 129 TLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNP 188
++ D G F+C + + KD + G L V P F P
Sbjct: 4171 EIIRVDMNDAGNFTC---RATNSVGSKDSS------------GALIVQEPPSF---VTKP 4212
Query: 189 DRQAVVPCRVTVL------SAKVTLHREFPAKEIPANGTDIVYDMKRGF-----VYLQPH 237
+ V+P L S +T+ KE+ + G+ Y K +YL
Sbjct: 4213 GSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGS--CYITKEALESSLELYLVKT 4270
Query: 238 SEHQGVVYCR-AEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVL 296
S+ G C+ + G + S L+V P+ L S +K GD + C V
Sbjct: 4271 SD-SGTYTCKVSNVAGGVECSAN---LFVKEPA--TFVEKLEPSQLLKKGDATQLACKVT 4324
Query: 297 GEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYI 356
G P +++ TW ++R + R+ + S +V+ + D D+G Y+
Sbjct: 4325 GTPPIKI--TWF----ANDREIKESSKHRM-------SFVESTAVLRLTDVGIEDSGEYM 4371
Query: 357 CTAQNLQGQTTVATTV 372
C AQN G ++ V
Sbjct: 4372 CEAQNEAGSDHCSSIV 4387
Score = 38.9 bits (89), Expect = 0.008
Identities = 37/133 (27%), Positives = 55/133 (41%), Gaps = 20/133 (15%)
Query: 239 EHQGVVYCRAE-AGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLG 297
E G C E A G+ S + +L PP KV GD S+ C + G
Sbjct: 7933 EDAGQYNCYIENASGKDSCSAQILILE------PPYFVKQLEPVKVSVGDSASLQCQLAG 7986
Query: 298 EPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYIC 357
P++ V + + G RP T T+++ R T +Q I D+G YIC
Sbjct: 7987 TPEIGVSW---YKGDTKLRPTT---TYKMHFRNNVATLVFNQVDIN-------DSGEYIC 8033
Query: 358 TAQNLQGQTTVAT 370
A+N G+ + +T
Sbjct: 8034 KAENSVGEVSAST 8046
Score = 37.4 bits (85), Expect = 0.022
Identities = 24/108 (22%), Positives = 48/108 (44%), Gaps = 13/108 (12%)
Query: 265 VAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTW 324
++V P L +S K G+ I + C + G P+++V +W + ++W
Sbjct: 6358 LSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKV--SWF------RNDSELHESW 6409
Query: 325 RLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+ + S +++T+ + D+G YIC A N G + +T +
Sbjct: 6410 KYNMSFIN-----SVALLTINEASAEDSGDYICEAHNGVGDASCSTAL 6452
Score = 37.0 bits (84), Expect = 0.029
Identities = 70/311 (22%), Positives = 116/311 (37%), Gaps = 56/311 (18%)
Query: 77 FQKPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRL--SVKQNERYGQLTLV--- 131
F K ++ G L+C+ S G P + FKD + S K+ + Q +LV
Sbjct: 3833 FIKTLEPADIVRGTNALLQCEVSGTG---PFEISWFKDKKQIRSSKKYRLFSQKSLVCLE 3889
Query: 132 --NSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPD 189
+ SAD GE+ C + + K G ++ FV D++ L
Sbjct: 3890 IFSFNSADVGEYEC--------VVANEVGKCGCMATHLLKEPPTFVKKVD--DLIALGGQ 3939
Query: 190 R---QAVV----PCRVTVLSAKVTLHREFPAKEIPANGTD--IVYDMKRGFVYLQPHSEH 240
QA V P VT + + + + K +NG I+ D++ F
Sbjct: 3940 TVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISF--------- 3990
Query: 241 QGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPD 300
G C AE SQ SV ++ P A +V +GD ++ TV G P+
Sbjct: 3991 GGKYTCLAENEAGSQTSVGELIV-----KEPAKIIERAELIQVTAGDPATLEYTVAGTPE 4045
Query: 301 VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQ 360
++ ++ KD RP+ +R+ + + + + E D+G Y
Sbjct: 4046 LKPKW------YKDGRPLVASKKYRISFKN-------NVAQLKFYSAELHDSGQYTFEIS 4092
Query: 361 NLQGQTTVATT 371
N G ++ TT
Sbjct: 4093 NEVGSSSCETT 4103
Score = 37.0 bits (84), Expect = 0.029
Identities = 24/90 (26%), Positives = 43/90 (47%), Gaps = 13/90 (14%)
Query: 283 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI 342
VK+G I + TV G+P+ ++ +T K ++ +TI++ + +S +
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPK-------------KSTV 13748
Query: 343 TVEDFETIDAGYYICTAQNLQGQTTVATTV 372
T+ D + D G YI A N+ G+ T V
Sbjct: 13749 TIVDSKRSDTGTYIIEAVNVCGRATAVVEV 13778
Score = 35.8 bits (81), Expect = 0.064
Identities = 27/104 (25%), Positives = 44/104 (42%), Gaps = 13/104 (12%)
Query: 271 PPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRG 330
PP T S G D+ + C + G P EV W+ KD + V +++
Sbjct: 6457 PPVFTQKPSPVGALKGSDVILQCEISGTPPFEV--VWV----KDRKQVRNSKKFKI---- 6506
Query: 331 LGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVEF 374
T++ + + + + E D G Y C A N G T + +V+F
Sbjct: 6507 ---TSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKF 6547
Score = 35.4 bits (80), Expect = 0.084
Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 17/104 (16%)
Query: 263 LYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQD 322
L V+ + PPS T SG + + C V G P + V +W G +
Sbjct: 7673 LQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISV--SWFHEGNE--------- 7721
Query: 323 TWRLIHRGLGHTTRISQS--VITVEDFETIDAGYYICTAQNLQG 364
I G + T ++ + +TV E D+G Y C A N+ G
Sbjct: 7722 ----ISSGRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAG 7761
Score = 34.3 bits (77), Expect = 0.19
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 20/137 (14%)
Query: 238 SEHQGVVYCRAE-AGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVL 296
+E G C A+ G + S K + PP + + ++S+ C +
Sbjct: 5488 TEDSGDFICEAQNPAGSTSCSTK------VIVKEPPVFSSFPPIVETLKNAEVSLECELS 5541
Query: 297 GEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYI 356
G P EV W KD+R + +++ + HT+ I + + +T D G Y
Sbjct: 5542 GTPPFEV--VWY----KDKRQLRSSKKYKIASKNF-HTS------IHILNVDTSDIGEYH 5588
Query: 357 CTAQNLQGQTTVATTVE 373
C AQN G T TV+
Sbjct: 5589 CKAQNEVGSDTCVCTVK 5605
Score = 34.3 bits (77), Expect = 0.19
Identities = 27/138 (19%), Positives = 55/138 (39%), Gaps = 14/138 (10%)
Query: 235 QPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCT 294
Q +G++ C ++ + +Y L S P+ S + G ++ C
Sbjct: 33098 QASHRDEGILTCISKTK-EGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCE 33156
Query: 295 VLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGY 354
+ GEP E+E W K+ P++I + ++ I + ++ D+G
Sbjct: 33157 ISGEPSPEIE--WF----KNNLPISISSNVSISRSRNVYSLEIRNASVS-------DSGK 33203
Query: 355 YICTAQNLQGQTTVATTV 372
Y A+N +GQ + ++
Sbjct: 33204 YTIKAKNFRGQCSATASL 33221
Score = 33.1 bits (74), Expect = 0.42
Identities = 28/100 (28%), Positives = 40/100 (40%), Gaps = 25/100 (25%)
Query: 277 LASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTR 336
L +S K+G+D+ VL G P P T+ TWR + LG R
Sbjct: 27277 LRTSVIAKAGEDVQVLIPFKGRP-----------------PPTV--TWRKDEKNLGSDAR 27317
Query: 337 I------SQSVITVEDFETIDAGYYICTAQNLQGQTTVAT 370
S S++T+ D G YI T +N G+ +T
Sbjct: 27318 YSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSST 27357
Score = 32.7 bits (73), Expect = 0.55
Identities = 29/130 (22%), Positives = 52/130 (40%), Gaps = 28/130 (21%)
Query: 252 GRSQISVKYQLLYVAVPSGPPSTTILASSNKV---KSGDDISVLCTVLGEPDVEVEFTWI 308
G S+ + + + P P+ + +N++ K+G ++ + G P +V
Sbjct: 28625 GYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKV----- 28679
Query: 309 FPGQKDERPVTIQDTWRLIHRGLGHTTRIS------QSVITVEDFETIDAGYYICTAQNL 362
TW+L L T R+S ++ +TV+D D+G Y T +N
Sbjct: 28680 --------------TWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSGRYFLTLENT 28725
Query: 363 QGQTTVATTV 372
G T + TV
Sbjct: 28726 AGVKTFSVTV 28735
Score = 32.3 bits (72), Expect = 0.71
Identities = 25/113 (22%), Positives = 48/113 (42%), Gaps = 16/113 (14%)
Query: 252 GRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPG 311
GRS + +L + +P P T L + +K G I + C V G + ++ W
Sbjct: 4658 GRSSCKARINVLDLIIP--PSFTKKLKKMDSIK-GSFIDLECIVAGSHPISIQ--WF--- 4709
Query: 312 QKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQG 364
KD++ ++ + ++ + + + + E D+G Y C+A N G
Sbjct: 4710 -KDDQEISASEKYKFSFHD-------NTAFLEISQLEGTDSGTYTCSATNKAG 4754
Score = 32.0 bits (71), Expect = 0.93
Identities = 27/101 (26%), Positives = 44/101 (43%), Gaps = 25/101 (24%)
Query: 271 PPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRG 330
PP+ +L ++ V +G+D+ V +G P V TW KD P
Sbjct: 22147 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAV--TW----HKDNVP------------- 22187
Query: 331 LGHTTRI------SQSVITVEDFETIDAGYYICTAQNLQGQ 365
L TTR+ + S++T++D D G+Y+ N G+
Sbjct: 22188 LKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGE 22228
Score = 31.2 bits (69), Expect = 1.6
Identities = 24/91 (26%), Positives = 43/91 (47%), Gaps = 13/91 (14%)
Query: 283 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI 342
V +G+ V + G+P ++ WI Q+ + +T RL + T +S
Sbjct: 22555 VHAGESFKVDADIYGKPIPTIQ--WIKGDQE------LSNTARLEIKSTDFATSLS---- 22602
Query: 343 TVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
V+D +D+G YI A+N+ G+ +V V+
Sbjct: 22603 -VKDAVRVDSGNYILKAKNVAGERSVTVNVK 22632
Score = 31.2 bits (69), Expect = 1.6
Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 6/56 (10%)
Query: 312 QKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTT 367
+KD +P+++ +IH GL + + + D D GYY TA N G T+
Sbjct: 31829 EKDGQPLSLGPNIEIIHEGLDYYA------LHIRDTLPEDTGYYRVTATNTAGSTS 31878
Score = 30.8 bits (68), Expect = 2.1
Identities = 26/90 (28%), Positives = 37/90 (41%), Gaps = 11/90 (12%)
Query: 283 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI 342
VK+GD I + V G+P EV +T KD +T ++ TR S
Sbjct: 18213 VKAGDTIRLEAGVRGKPFPEVAWT----KDKDATDLTRSPRVKI-------DTRADSSKF 18261
Query: 343 TVEDFETIDAGYYICTAQNLQGQTTVATTV 372
++ + D G Y+ TA N G TV
Sbjct: 18262 SLTKAKRSDGGKYVVTATNTAGSFVAYATV 18291
Score = 30.8 bits (68), Expect = 2.1
Identities = 24/90 (26%), Positives = 44/90 (48%), Gaps = 13/90 (14%)
Query: 284 KSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVIT 343
K+GD+I V VLG P V TW +K ++ ++ T R+ T + +++
Sbjct: 21078 KAGDNIKVEIPVLGRPKPTV--TW----KKGDQ--ILKQTQRV-----NFETTATSTILN 21124
Query: 344 VEDFETIDAGYYICTAQNLQGQTTVATTVE 373
+ + D+G Y TA+N+ G+ T++
Sbjct: 21125 INECVRSDSGPYPLTARNIVGEVGDVITIQ 21154
Score = 30.4 bits (67), Expect = 2.7
Identities = 30/121 (24%), Positives = 51/121 (42%), Gaps = 17/121 (14%)
Query: 252 GRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPG 311
GR++ SV LYV P PP V+SG + G P ++ +
Sbjct: 3223 GRNRSSVT---LYVNAPE-PPQVLQELQPVTVQSGKPARFCAVISGRPQPKISW------ 3272
Query: 312 QKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATT 371
K+E+ ++ + +H G +T ++ +E F DA Y C A+N G T + +
Sbjct: 3273 YKEEQLLSTGFKCKFLHDGQEYT------LLLIEAFPE-DAAVYTCEAKNDYGVATTSAS 3325
Query: 372 V 372
+
Sbjct: 3326 L 3326
Score = 30.4 bits (67), Expect = 2.7
Identities = 60/267 (22%), Positives = 104/267 (38%), Gaps = 49/267 (18%)
Query: 116 RLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFV 175
R+S +N+ L L N T D G +SC K K G+ + EL +
Sbjct: 3598 RISDAENKHI--LELSNLTIQDRGVYSC-----------KASNKFGADIC----QAELII 3640
Query: 176 PSPSYFDVVYLNPDRQAV-----VPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRG 230
+F + L P + A+ + C+V KVT+ +++P G D +
Sbjct: 3641 IDKPHF-IKELEPVQSAINKKVHLECQVDE-DRKVTVTWSKDGQKLPP-GKDYKICFEDK 3697
Query: 231 FVYLQ---PHSEHQGVVYCRA--EAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKS 285
L+ + G C A EAG S + V V P + S +
Sbjct: 3698 IATLEIPLAKLKDSGTYVCTASNEAGSSSCSAT------VTVREPPSFVKKVDPSYLMLP 3751
Query: 286 GDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVE 345
G+ + C + G P ++V TW K+ + ++ +T R+ S++++ +
Sbjct: 3752 GESARLHCKLKGSPVIQV--TWF----KNNKELSESNTVRMYFVN-------SEAILDIT 3798
Query: 346 DFETIDAGYYICTAQNLQGQTTVATTV 372
D + D+G Y C A N G + +T +
Sbjct: 3799 DVKVEDSGSYSCEAVNDVGSDSCSTEI 3825
Score = 30.4 bits (67), Expect = 2.7
Identities = 24/110 (21%), Positives = 45/110 (40%), Gaps = 13/110 (11%)
Query: 263 LYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQD 322
+ + P PP + V G+ + + C V G + ++ W+ G++ I+
Sbjct: 8337 IVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQ--WLKAGRE------IKP 8388
Query: 323 TWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+ R T +V+ + D D+G Y+C A N+ G T + V
Sbjct: 8389 SDRCSFSFASGT-----AVLELRDVAKADSGDYVCKASNVAGSDTTKSKV 8433
Score = 30.4 bits (67), Expect = 2.7
Identities = 21/98 (21%), Positives = 44/98 (44%), Gaps = 17/98 (17%)
Query: 272 PSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQ--KDERPVTIQDTWRLIHR 329
PS + ++ +++G+D+ + V+G P + +W+ G+ K V +++T
Sbjct: 24312 PSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNI--SWVKDGEPLKQTTRVNVEET------ 24363
Query: 330 GLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTT 367
+ +V+ +++ D G Y TA N G T
Sbjct: 24364 -------ATSTVLHIKEGNKDDFGKYTVTATNSAGTAT 24394
Score = 30.4 bits (67), Expect = 2.7
Identities = 17/53 (32%), Positives = 24/53 (45%), Gaps = 2/53 (3%)
Query: 261 QLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQK 313
++L + PP L S + G ++V C GEP EV TW G+K
Sbjct: 33318 KMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEV--TWSCGGRK 33368
Score = 30.0 bits (66), Expect = 3.5
Identities = 22/96 (22%), Positives = 42/96 (43%), Gaps = 13/96 (13%)
Query: 272 PSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGL 331
P ++ +K+G + + V G+P ++ +K E V + + +H+
Sbjct: 18899 PPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKW------KKGEDEV-VTSSHLAVHKA- 18950
Query: 332 GHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTT 367
S S++ ++D D+GYY TA+N G T
Sbjct: 18951 -----DSSSILIIKDVTRKDSGYYSLTAENSSGTDT 18981
Score = 30.0 bits (66), Expect = 3.5
Identities = 17/41 (41%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 333 HTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
HTT S S +TVE+ DAG Y T +N G ++ TV+
Sbjct: 28405 HTTD-SFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVK 28444
Score = 29.6 bits (65), Expect = 4.6
Identities = 22/85 (25%), Positives = 35/85 (41%), Gaps = 13/85 (15%)
Query: 286 GDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVE 345
GD +S+ C V G P++ V + + G RP T+ T ++ V
Sbjct: 6093 GDSVSLQCQVAGTPEITVSW---YKGDTKLRPTPEYRTY--------FTNNVATLVFNKV 6141
Query: 346 DFETIDAGYYICTAQNLQGQTTVAT 370
+ D+G Y C A+N G + T
Sbjct: 6142 NIN--DSGEYTCKAENSIGTASSKT 6164
Score = 28.9 bits (63), Expect = 7.9
Identities = 23/97 (23%), Positives = 41/97 (42%), Gaps = 13/97 (13%)
Query: 277 LASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTR 336
L S VK + C + G P+++V W KDE + +R+
Sbjct: 7311 LEPSRIVKQDEFTRYECKIGGSPEIKV--LWY----KDETEIQESSKFRMSFVD------ 7358
Query: 337 ISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
S +V+ + + D+G Y C A N G + +T+++
Sbjct: 7359 -SVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLK 7394
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 51.6 bits (122), Expect = 1e-06
Identities = 70/287 (24%), Positives = 104/287 (36%), Gaps = 43/287 (14%)
Query: 88 AGQTVELRCKGSRIGWSYPAYLDTFKDSR---LSVKQNERYGQLTLVNSTSADTGEFSCW 144
AG TVEL C S G+ PA + KD R + +R LT+ + + D+G + C
Sbjct: 299 AGHTVELPCTAS--GYPIPA-IRWLKDGRPLPADSRWTKRITGLTISDLRTEDSGTYICE 355
Query: 145 VQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAK 204
V +T+ G L V P + V L P + +LS
Sbjct: 356 VT---------------NTFGSAEATGILMVIDPLH---VTLTPKKLKTGIGSTVILSCA 397
Query: 205 VTLHREFPAK-------EIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQIS 257
+T EF + +P I + H G C A ++Q +
Sbjct: 398 LTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATR--KAQTA 455
Query: 258 VKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERP 317
+ + +A+ G P S V G+ S++C G P V TW D+ P
Sbjct: 456 QDFAI--IALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTV--TWAL----DDEP 507
Query: 318 VTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQG 364
+ + R + T IS +T D G Y CTA+NL G
Sbjct: 508 IVRDGSHRTNQYTMSDGTTISHMNVTGPQIR--DGGVYRCTARNLVG 552
Score = 35.8 bits (81), Expect = 0.064
Identities = 26/85 (30%), Positives = 37/85 (43%), Gaps = 17/85 (20%)
Query: 280 SNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQ 339
S +V +G + + CT G P + W+ KD RP+ W T RI+
Sbjct: 294 SQEVWAGHTVELPCTASGYPIPAIR--WL----KDGRPLPADSRW---------TKRITG 338
Query: 340 SVITVEDFETIDAGYYICTAQNLQG 364
+T+ D T D+G YIC N G
Sbjct: 339 --LTISDLRTEDSGTYICEVTNTFG 361
Score = 35.0 bits (79), Expect = 0.11
Identities = 27/103 (26%), Positives = 45/103 (43%), Gaps = 14/103 (13%)
Query: 268 PSGPPSTTILASSNKVKSG--DDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWR 325
P+G I++ V + D+ + C +G+P V+ W + PV++ D R
Sbjct: 1344 PAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVK--WTKDSEDSAIPVSM-DGHR 1400
Query: 326 LIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTV 368
LIH + + + + D+GYY CTA N G T+
Sbjct: 1401 LIH---------TNGTLLLRAVKAEDSGYYTCTATNTGGFDTI 1434
>gi|88979855 PREDICTED: similar to v-kit Hardy-Zuckerman 4 feline
sarcoma viral oncogene homolog [Homo sapiens]
Length = 208
Score = 51.2 bits (121), Expect = 1e-06
Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 9/191 (4%)
Query: 184 VYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQ-PHSEHQG 242
+Y D +V C +T + K +P + + D K G + + H+
Sbjct: 16 LYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKD-LRFIPDPKAGIMIKSVKRAYHRL 74
Query: 243 VVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVE 302
++C + G+S +S K+ L P ++ +S ++ G++ +V CT+ +
Sbjct: 75 CLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIK-DVSSS 133
Query: 303 VEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNL 362
V TW +++ +Q+ + H G + R Q+ +T+ D+G ++C A N
Sbjct: 134 VYSTW----KRENSQTKLQEKYNSWHHGDFNYER--QATLTISSARVNDSGVFMCYANNT 187
Query: 363 QGQTTVATTVE 373
G V TT+E
Sbjct: 188 FGSANVTTTLE 198
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 50.8 bits (120), Expect = 2e-06
Identities = 70/292 (23%), Positives = 116/292 (39%), Gaps = 51/292 (17%)
Query: 85 SLLAGQTVELRC--KGS---RIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSA--D 137
SL G + LRC +GS RIGW T D ++ +E+ G TL + + D
Sbjct: 2948 SLRLGDRLWLRCAARGSPTPRIGW-------TVNDRPVTEGVSEQDGGSTLQRAAVSRED 3000
Query: 138 TGEFSCWVQLCSGYICRKDEAKTGSTY-IFFTEKGELFVPSPSYFDVVYLNPDRQAVVPC 196
+G + CW E + G T + F E V F + + C
Sbjct: 3001 SGTYVCWA-----------ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDC 3049
Query: 197 RVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYL-QPHSEHQGVVYCRAEAGGRSQ 255
V+ + +P G+ + + ++ G + + + + G C AE ++
Sbjct: 3050 ---VVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAE----NE 3102
Query: 256 ISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDE 315
+ V +++ + + S P + V+SGDD+++ C GEP +E W+ GQ
Sbjct: 3103 MGVAKKVVILVLQSAPVFQ-VEPQDMTVRSGDDVALRCQATGEPTPTIE--WLQAGQ--- 3156
Query: 316 RPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTT 367
P+ R + G + +E+ ET DAG Y C A NL G T
Sbjct: 3157 -PLRASRRLRTLPDGS----------LWLENVETGDAGTYDCVAHNLLGSAT 3197
Score = 38.9 bits (89), Expect = 0.008
Identities = 72/318 (22%), Positives = 124/318 (38%), Gaps = 62/318 (19%)
Query: 49 IPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAY 108
+P R + P T S +QVL +GR LL Q ++ G + +
Sbjct: 1475 VPPPTIRWYKDGQPVTPSSRLQVLGEGR---------LLQIQPTQVSDSGRYLCVA---- 1521
Query: 109 LDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFT 168
+ ++ + ++ + L V G+FS ++ S R++EA+ G T
Sbjct: 1522 ------TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS----REEEARGG-----VT 1566
Query: 169 EKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMK 228
E E+ +P+Y L D A+ P +T +RE + P + D V ++
Sbjct: 1567 EYREIVENNPAY-----LYCDTNAIPP-------PDLTWYRE----DQPLSAGDEVSVLQ 1610
Query: 229 RGFVYLQP--HSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSG 286
G V P +E+ G C+A + + + Y+LL + P T L V +
Sbjct: 1611 GGRVLQIPLVRAENAGRYSCKA-SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNAS 1669
Query: 287 DDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVED 346
+S+ C LG P + +W+ G P + +++ G V+ V
Sbjct: 1670 STVSLQCPALGNPVPTI--SWLQNGL----PFSPSPRLQVLEDG---------QVLQVST 1714
Query: 347 FETIDAGYYICTAQNLQG 364
E DA Y+C A+N G
Sbjct: 1715 AEVADAASYMCVAENQAG 1732
Score = 37.0 bits (84), Expect = 0.029
Identities = 77/342 (22%), Positives = 131/342 (38%), Gaps = 45/342 (13%)
Query: 34 GENRIKPTNKKVKPK-IPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAA-TLSLLAGQT 91
G R++ +V K + K + A A +T ++ +QV F+ P T+S +AG
Sbjct: 1893 GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV--PPTFENPKTETVSQVAGSP 1950
Query: 92 VELRCKGSRIGWSYPAYLDTFKDSRLSVKQN------ERYGQLTLVNSTSADTGEFSCWV 145
+ L C S + PA T+ R+ V+ + R G+L L A G ++C
Sbjct: 1951 LVLTCDVSGV----PAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVA 2006
Query: 146 QLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKV 205
+ RKD G V L+ + P V L
Sbjct: 2007 ENTQAE-ARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGS 2065
Query: 206 TLHREFPAKEIPANGTDIVYDMKRGFVYLQP-HSEHQGVVYCRAE--AGGRSQISVKYQL 262
L ++ G + + + G + L+ + G C A AG +++ L
Sbjct: 2066 PLGQDM--------GPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVL 2117
Query: 263 LYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQD 322
+ + G + L S + G+ ++++C V G P + V +W+ KD P+ +
Sbjct: 2118 VPPTIKQGADGSGTLVS----RPGELVTMVCPVRGSPPIHV--SWL----KDGLPLPLSQ 2167
Query: 323 TWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQG 364
R + G GHT RIS+ + DAG + C A + G
Sbjct: 2168 --RTLLHGSGHTLRISK-------VQLADAGIFTCVAASPAG 2200
Score = 35.8 bits (81), Expect = 0.064
Identities = 32/128 (25%), Positives = 57/128 (44%), Gaps = 24/128 (18%)
Query: 241 QGVVYCRA-EAGGRSQISVKYQLLYVA-VPSGPPSTTILASSNKVKSGDDISVLCTVLGE 298
+G+ C A G S+ V ++L + GP + +L +++ +++ C G
Sbjct: 669 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENAS-------VTLECLASGV 721
Query: 299 PDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICT 358
P +V +W K +PV+ +W +G T + V+ +E + DAG Y C
Sbjct: 722 PPPDV--SWF----KGHQPVS---SW------MGVTVSVDGRVLRIEQAQLSDAGSYRCV 766
Query: 359 AQNLQGQT 366
A N+ G T
Sbjct: 767 ASNVAGST 774
Score = 34.7 bits (78), Expect = 0.14
Identities = 66/259 (25%), Positives = 100/259 (38%), Gaps = 50/259 (19%)
Query: 121 QNERYGQ-LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPS 179
Q + GQ L + + +A TG +SC + +G RK E + VP
Sbjct: 1115 QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELS-------------VLVPPEL 1161
Query: 180 YFDVVYLNPDRQAVVPCRVTVLSAKVTLH----REFPAKEIPANGTDIVYDMKRGFVYLQ 235
D+ L + A + +T+L + + R F +E + G D Y + G++
Sbjct: 1162 IGDLDPLT-NITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGED-TYLLAGGWMLKM 1219
Query: 236 PHSEHQ--GVVYCRA--EAG-GRSQISVKYQLLYVAVPSGPPS--TTILASSNKVKSGDD 288
++ Q G+ C A EAG R SV+ + PPS L KV G
Sbjct: 1220 TQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--------PPSIENEDLEEVIKVLDGQT 1271
Query: 289 ISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFE 348
++C V G P + + TW KD RP+ RG H ++ V
Sbjct: 1272 AHLMCNVTGHP--QPKLTWF----KDGRPLA---------RGDAHHISPDGVLLQVLQAN 1316
Query: 349 TIDAGYYICTAQNLQGQTT 367
AG+Y C A N G+ T
Sbjct: 1317 LSSAGHYSCIAANAVGEKT 1335
Score = 33.5 bits (75), Expect = 0.32
Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 26/159 (16%)
Query: 217 PANGTDIVYDMKRGFVYLQPHSEHQ--GVVYCRAE-AGGRSQISVKYQLLYVAVPSGPPS 273
P +G + + ++ L + E Q G C AE A GR++ V +L + P
Sbjct: 2886 PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL------PV 2939
Query: 274 TTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGH 333
T L ++ GD + + C G P + +T ++RPVT G
Sbjct: 2940 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT------VNDRPVTE-----------GV 2982
Query: 334 TTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+ + S + D+G Y+C A+N G+T + V
Sbjct: 2983 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 3021
Score = 31.6 bits (70), Expect = 1.2
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 342 ITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
+ ++ T D+G Y CTA+N G T+VA VE
Sbjct: 2446 LQLQALSTADSGDYSCTARNAAGSTSVAFRVE 2477
Score = 30.8 bits (68), Expect = 2.1
Identities = 31/136 (22%), Positives = 52/136 (38%), Gaps = 26/136 (19%)
Query: 242 GVVYCRA-EAGGRSQISVKYQLL----YVAVPSGPPSTTILASSNKVKSGDDISVLCTVL 296
G+ C A A GR Q V+ +L + P GP + V+ GD + C
Sbjct: 1813 GMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVL------VRVGDKAVLSCETD 1866
Query: 297 GEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYI 356
P+ V TW KD +P+ + + + G + +++ + D G Y
Sbjct: 1867 ALPEPTV--TWY----KDGQPLVLAQRTQALRGG---------QRLEIQEAQVSDKGLYS 1911
Query: 357 CTAQNLQGQTTVATTV 372
C N+ G+ T+
Sbjct: 1912 CKVSNVAGEAVRTFTL 1927
Score = 30.8 bits (68), Expect = 2.1
Identities = 46/217 (21%), Positives = 78/217 (35%), Gaps = 27/217 (12%)
Query: 151 YICR-KDEAKTGSTYIFFTEKGELFV-PSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLH 208
Y C ++ A ++F T + V P PS VV + + ++PC + +
Sbjct: 2734 YTCSARNSAGVAHKHVFLTVQASPVVKPLPS---VVRAVAEEEVLLPCEASGIPRPTITW 2790
Query: 209 REFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVP 268
++ T ++ + + P E G C A+ S + ++ V
Sbjct: 2791 QKEGLNVATGVSTQVLPGGQLRIAHASP--EDAGNYLCIAKNSAGSAMGKTRLVVQV--- 2845
Query: 269 SGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIH 328
PP G + C G P+ + TW KD +PV+ +
Sbjct: 2846 --PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI--TW----DKDGQPVSGAE------ 2891
Query: 329 RGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQ 365
G T + V++ E DAG Y CTA+N G+
Sbjct: 2892 ---GKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR 2925
Score = 29.6 bits (65), Expect = 4.6
Identities = 33/130 (25%), Positives = 51/130 (39%), Gaps = 26/130 (20%)
Query: 248 AEAGGRSQISV----------KYQLLYVAVPSGPPSTTILASSNKVK--SGDDISVLCTV 295
A+AGG +Q ++ + P PPS ++ +V +G D+ + C
Sbjct: 182 AQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWT 241
Query: 296 LGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYY 355
G P +VE+T KD +PV + G RI+ S + D G Y
Sbjct: 242 SGVPTPQVEWT------KDRQPVLPGGPHLQVQED-GQVLRITGSHVG-------DEGRY 287
Query: 356 ICTAQNLQGQ 365
C A + GQ
Sbjct: 288 QCVAFSPAGQ 297
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 50.8 bits (120), Expect = 2e-06
Identities = 70/292 (23%), Positives = 116/292 (39%), Gaps = 51/292 (17%)
Query: 85 SLLAGQTVELRC--KGS---RIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSA--D 137
SL G + LRC +GS RIGW T D ++ +E+ G TL + + D
Sbjct: 4139 SLRLGDRLWLRCAARGSPTPRIGW-------TVNDRPVTEGVSEQDGGSTLQRAAVSRED 4191
Query: 138 TGEFSCWVQLCSGYICRKDEAKTGSTY-IFFTEKGELFVPSPSYFDVVYLNPDRQAVVPC 196
+G + CW E + G T + F E V F + + C
Sbjct: 4192 SGTYVCWA-----------ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDC 4240
Query: 197 RVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYL-QPHSEHQGVVYCRAEAGGRSQ 255
V+ + +P G+ + + ++ G + + + + G C AE ++
Sbjct: 4241 ---VVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAE----NE 4293
Query: 256 ISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDE 315
+ V +++ + + S P + V+SGDD+++ C GEP +E W+ GQ
Sbjct: 4294 MGVAKKVVILVLQSAPVFQ-VEPQDMTVRSGDDVALRCQATGEPTPTIE--WLQAGQ--- 4347
Query: 316 RPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTT 367
P+ R + G + +E+ ET DAG Y C A NL G T
Sbjct: 4348 -PLRASRRLRTLPDGS----------LWLENVETGDAGTYDCVAHNLLGSAT 4388
Score = 38.9 bits (89), Expect = 0.008
Identities = 72/318 (22%), Positives = 124/318 (38%), Gaps = 62/318 (19%)
Query: 49 IPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAY 108
+P R + P T S +QVL +GR LL Q ++ G + +
Sbjct: 2666 VPPPTIRWYKDGQPVTPSSRLQVLGEGR---------LLQIQPTQVSDSGRYLCVA---- 2712
Query: 109 LDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFT 168
+ ++ + ++ + L V G+FS ++ S R++EA+ G T
Sbjct: 2713 ------TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS----REEEARGG-----VT 2757
Query: 169 EKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMK 228
E E+ +P+Y L D A+ P +T +RE + P + D V ++
Sbjct: 2758 EYREIVENNPAY-----LYCDTNAIPP-------PDLTWYRE----DQPLSAGDEVSVLQ 2801
Query: 229 RGFVYLQP--HSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSG 286
G V P +E+ G C+A + + + Y+LL + P T L V +
Sbjct: 2802 GGRVLQIPLVRAENAGRYSCKA-SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNAS 2860
Query: 287 DDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVED 346
+S+ C LG P + +W+ G P + +++ G V+ V
Sbjct: 2861 STVSLQCPALGNPVPTI--SWLQNGL----PFSPSPRLQVLEDG---------QVLQVST 2905
Query: 347 FETIDAGYYICTAQNLQG 364
E DA Y+C A+N G
Sbjct: 2906 AEVADAASYMCVAENQAG 2923
Score = 37.0 bits (84), Expect = 0.029
Identities = 77/342 (22%), Positives = 131/342 (38%), Gaps = 45/342 (13%)
Query: 34 GENRIKPTNKKVKPK-IPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAA-TLSLLAGQT 91
G R++ +V K + K + A A +T ++ +QV F+ P T+S +AG
Sbjct: 3084 GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV--PPTFENPKTETVSQVAGSP 3141
Query: 92 VELRCKGSRIGWSYPAYLDTFKDSRLSVKQN------ERYGQLTLVNSTSADTGEFSCWV 145
+ L C S + PA T+ R+ V+ + R G+L L A G ++C
Sbjct: 3142 LVLTCDVSGV----PAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVA 3197
Query: 146 QLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKV 205
+ RKD G V L+ + P V L
Sbjct: 3198 ENTQAE-ARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGS 3256
Query: 206 TLHREFPAKEIPANGTDIVYDMKRGFVYLQP-HSEHQGVVYCRAE--AGGRSQISVKYQL 262
L ++ G + + + G + L+ + G C A AG +++ L
Sbjct: 3257 PLGQDM--------GPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVL 3308
Query: 263 LYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQD 322
+ + G + L S + G+ ++++C V G P + V +W+ KD P+ +
Sbjct: 3309 VPPTIKQGADGSGTLVS----RPGELVTMVCPVRGSPPIHV--SWL----KDGLPLPLSQ 3358
Query: 323 TWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQG 364
R + G GHT RIS+ + DAG + C A + G
Sbjct: 3359 --RTLLHGSGHTLRISK-------VQLADAGIFTCVAASPAG 3391
Score = 36.6 bits (83), Expect = 0.038
Identities = 24/100 (24%), Positives = 38/100 (38%), Gaps = 15/100 (15%)
Query: 267 VPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRL 326
V + PP + A + V G+ + C VLGE + TW+ WR+
Sbjct: 512 VVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNL--TWV-------------RDWRV 556
Query: 327 IHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQT 366
+ G +++ + + D G Y C A N G T
Sbjct: 557 LPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT 596
Score = 35.8 bits (81), Expect = 0.064
Identities = 32/128 (25%), Positives = 57/128 (44%), Gaps = 24/128 (18%)
Query: 241 QGVVYCRA-EAGGRSQISVKYQLLYVA-VPSGPPSTTILASSNKVKSGDDISVLCTVLGE 298
+G+ C A G S+ V ++L + GP + +L +++ +++ C G
Sbjct: 1860 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENAS-------VTLECLASGV 1912
Query: 299 PDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICT 358
P +V +W K +PV+ +W +G T + V+ +E + DAG Y C
Sbjct: 1913 PPPDV--SWF----KGHQPVS---SW------MGVTVSVDGRVLRIEQAQLSDAGSYRCV 1957
Query: 359 AQNLQGQT 366
A N+ G T
Sbjct: 1958 ASNVAGST 1965
Score = 34.7 bits (78), Expect = 0.14
Identities = 66/259 (25%), Positives = 100/259 (38%), Gaps = 50/259 (19%)
Query: 121 QNERYGQ-LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPS 179
Q + GQ L + + +A TG +SC + +G RK E + VP
Sbjct: 2306 QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELS-------------VLVPPEL 2352
Query: 180 YFDVVYLNPDRQAVVPCRVTVLSAKVTLH----REFPAKEIPANGTDIVYDMKRGFVYLQ 235
D+ L + A + +T+L + + R F +E + G D Y + G++
Sbjct: 2353 IGDLDPLT-NITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGED-TYLLAGGWMLKM 2410
Query: 236 PHSEHQ--GVVYCRA--EAG-GRSQISVKYQLLYVAVPSGPPS--TTILASSNKVKSGDD 288
++ Q G+ C A EAG R SV+ + PPS L KV G
Sbjct: 2411 TQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--------PPSIENEDLEEVIKVLDGQT 2462
Query: 289 ISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFE 348
++C V G P + + TW KD RP+ RG H ++ V
Sbjct: 2463 AHLMCNVTGHP--QPKLTWF----KDGRPLA---------RGDAHHISPDGVLLQVLQAN 2507
Query: 349 TIDAGYYICTAQNLQGQTT 367
AG+Y C A N G+ T
Sbjct: 2508 LSSAGHYSCIAANAVGEKT 2526
Score = 33.5 bits (75), Expect = 0.32
Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 26/159 (16%)
Query: 217 PANGTDIVYDMKRGFVYLQPHSEHQ--GVVYCRAE-AGGRSQISVKYQLLYVAVPSGPPS 273
P +G + + ++ L + E Q G C AE A GR++ V +L + P
Sbjct: 4077 PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL------PV 4130
Query: 274 TTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGH 333
T L ++ GD + + C G P + +T ++RPVT G
Sbjct: 4131 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT------VNDRPVTE-----------GV 4173
Query: 334 TTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+ + S + D+G Y+C A+N G+T + V
Sbjct: 4174 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 4212
Score = 31.6 bits (70), Expect = 1.2
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 342 ITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
+ ++ T D+G Y CTA+N G T+VA VE
Sbjct: 3637 LQLQALSTADSGDYSCTARNAAGSTSVAFRVE 3668
Score = 30.8 bits (68), Expect = 2.1
Identities = 31/136 (22%), Positives = 52/136 (38%), Gaps = 26/136 (19%)
Query: 242 GVVYCRA-EAGGRSQISVKYQLL----YVAVPSGPPSTTILASSNKVKSGDDISVLCTVL 296
G+ C A A GR Q V+ +L + P GP + V+ GD + C
Sbjct: 3004 GMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVL------VRVGDKAVLSCETD 3057
Query: 297 GEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYI 356
P+ V TW KD +P+ + + + G + +++ + D G Y
Sbjct: 3058 ALPEPTV--TWY----KDGQPLVLAQRTQALRGG---------QRLEIQEAQVSDKGLYS 3102
Query: 357 CTAQNLQGQTTVATTV 372
C N+ G+ T+
Sbjct: 3103 CKVSNVAGEAVRTFTL 3118
Score = 30.8 bits (68), Expect = 2.1
Identities = 46/217 (21%), Positives = 78/217 (35%), Gaps = 27/217 (12%)
Query: 151 YICR-KDEAKTGSTYIFFTEKGELFV-PSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLH 208
Y C ++ A ++F T + V P PS VV + + ++PC + +
Sbjct: 3925 YTCSARNSAGVAHKHVFLTVQASPVVKPLPS---VVRAVAEEEVLLPCEASGIPRPTITW 3981
Query: 209 REFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVP 268
++ T ++ + + P E G C A+ S + ++ V
Sbjct: 3982 QKEGLNVATGVSTQVLPGGQLRIAHASP--EDAGNYLCIAKNSAGSAMGKTRLVVQV--- 4036
Query: 269 SGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIH 328
PP G + C G P+ + TW KD +PV+ +
Sbjct: 4037 --PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI--TW----DKDGQPVSGAE------ 4082
Query: 329 RGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQ 365
G T + V++ E DAG Y CTA+N G+
Sbjct: 4083 ---GKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR 4116
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 50.8 bits (120), Expect = 2e-06
Identities = 70/292 (23%), Positives = 116/292 (39%), Gaps = 51/292 (17%)
Query: 85 SLLAGQTVELRC--KGS---RIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSA--D 137
SL G + LRC +GS RIGW T D ++ +E+ G TL + + D
Sbjct: 2857 SLRLGDRLWLRCAARGSPTPRIGW-------TVNDRPVTEGVSEQDGGSTLQRAAVSRED 2909
Query: 138 TGEFSCWVQLCSGYICRKDEAKTGSTY-IFFTEKGELFVPSPSYFDVVYLNPDRQAVVPC 196
+G + CW E + G T + F E V F + + C
Sbjct: 2910 SGTYVCWA-----------ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDC 2958
Query: 197 RVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQ-PHSEHQGVVYCRAEAGGRSQ 255
V+ + +P G+ + + ++ G + ++ + G C AE ++
Sbjct: 2959 ---VVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAE----NE 3011
Query: 256 ISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDE 315
+ V +++ + + S P + V+SGDD+++ C GEP +E W+ GQ
Sbjct: 3012 MGVAKKVVILVLQSAPVFQ-VEPQDMTVRSGDDVALRCQATGEPTPTIE--WLQAGQ--- 3065
Query: 316 RPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTT 367
P+ R + G + +E+ ET DAG Y C A NL G T
Sbjct: 3066 -PLRASRRLRTLPDGS----------LWLENVETGDAGTYDCVAHNLLGSAT 3106
Score = 38.9 bits (89), Expect = 0.008
Identities = 72/318 (22%), Positives = 124/318 (38%), Gaps = 62/318 (19%)
Query: 49 IPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGSRIGWSYPAY 108
+P R + P T S +QVL +GR LL Q ++ G + +
Sbjct: 1384 VPPPTIRWYKDGQPVTPSSRLQVLGEGR---------LLQIQPTQVSDSGRYLCVA---- 1430
Query: 109 LDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFT 168
+ ++ + ++ + L V G+FS ++ S R++EA+ G T
Sbjct: 1431 ------TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS----REEEARGG-----VT 1475
Query: 169 EKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMK 228
E E+ +P+Y L D A+ P +T +RE + P + D V ++
Sbjct: 1476 EYREIVENNPAY-----LYCDTNAIPP-------PDLTWYRE----DQPLSAGDEVSVLQ 1519
Query: 229 RGFVYLQP--HSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSG 286
G V P +E+ G C+A + + + Y+LL + P T L V +
Sbjct: 1520 GGRVLQIPLVRAENAGRYSCKA-SNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNAS 1578
Query: 287 DDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVED 346
+S+ C LG P + +W+ G P + +++ G V+ V
Sbjct: 1579 STVSLQCPALGNPVPTI--SWLQNGL----PFSPSPRLQVLEDG---------QVLQVST 1623
Query: 347 FETIDAGYYICTAQNLQG 364
E DA Y+C A+N G
Sbjct: 1624 AEVADAASYMCVAENQAG 1641
Score = 37.0 bits (84), Expect = 0.029
Identities = 77/342 (22%), Positives = 131/342 (38%), Gaps = 45/342 (13%)
Query: 34 GENRIKPTNKKVKPK-IPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAA-TLSLLAGQT 91
G R++ +V K + K + A A +T ++ +QV F+ P T+S +AG
Sbjct: 1802 GGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQV--PPTFENPKTETVSQVAGSP 1859
Query: 92 VELRCKGSRIGWSYPAYLDTFKDSRLSVKQN------ERYGQLTLVNSTSADTGEFSCWV 145
+ L C S + PA T+ R+ V+ + R G+L L A G ++C
Sbjct: 1860 LVLTCDVSGV----PAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVA 1915
Query: 146 QLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKV 205
+ RKD G V L+ + P V L
Sbjct: 1916 ENTQAE-ARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGS 1974
Query: 206 TLHREFPAKEIPANGTDIVYDMKRGFVYLQP-HSEHQGVVYCRAE--AGGRSQISVKYQL 262
L ++ G + + + G + L+ + G C A AG +++ L
Sbjct: 1975 PLGQDM--------GPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVL 2026
Query: 263 LYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQD 322
+ + G + L S + G+ ++++C V G P + V +W+ KD P+ +
Sbjct: 2027 VPPTIKQGADGSGTLVS----RPGELVTMVCPVRGSPPIHV--SWL----KDGLPLPLSQ 2076
Query: 323 TWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQG 364
R + G GHT RIS+ + DAG + C A + G
Sbjct: 2077 --RTLLHGSGHTLRISK-------VQLADAGIFTCVAASPAG 2109
Score = 35.8 bits (81), Expect = 0.064
Identities = 32/128 (25%), Positives = 57/128 (44%), Gaps = 24/128 (18%)
Query: 241 QGVVYCRA-EAGGRSQISVKYQLLYVA-VPSGPPSTTILASSNKVKSGDDISVLCTVLGE 298
+G+ C A G S+ V ++L + GP + +L +++ +++ C G
Sbjct: 578 EGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENAS-------VTLECLASGV 630
Query: 299 PDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICT 358
P +V +W K +PV+ +W +G T + V+ +E + DAG Y C
Sbjct: 631 PPPDV--SWF----KGHQPVS---SW------MGVTVSVDGRVLRIEQAQLSDAGSYRCV 675
Query: 359 AQNLQGQT 366
A N+ G T
Sbjct: 676 ASNVAGST 683
Score = 34.7 bits (78), Expect = 0.14
Identities = 66/259 (25%), Positives = 100/259 (38%), Gaps = 50/259 (19%)
Query: 121 QNERYGQ-LTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPS 179
Q + GQ L + + +A TG +SC + +G RK E + VP
Sbjct: 1024 QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELS-------------VLVPPEL 1070
Query: 180 YFDVVYLNPDRQAVVPCRVTVLSAKVTLH----REFPAKEIPANGTDIVYDMKRGFVYLQ 235
D+ L + A + +T+L + + R F +E + G D Y + G++
Sbjct: 1071 IGDLDPLT-NITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGED-TYLLAGGWMLKM 1128
Query: 236 PHSEHQ--GVVYCRA--EAG-GRSQISVKYQLLYVAVPSGPPS--TTILASSNKVKSGDD 288
++ Q G+ C A EAG R SV+ + PPS L KV G
Sbjct: 1129 TQTQEQDSGLYSCLASNEAGEARRNFSVEVLV--------PPSIENEDLEEVIKVLDGQT 1180
Query: 289 ISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFE 348
++C V G P + + TW KD RP+ RG H ++ V
Sbjct: 1181 AHLMCNVTGHP--QPKLTWF----KDGRPLA---------RGDAHHISPDGVLLQVLQAN 1225
Query: 349 TIDAGYYICTAQNLQGQTT 367
AG+Y C A N G+ T
Sbjct: 1226 LSSAGHYSCIAANAVGEKT 1244
Score = 33.5 bits (75), Expect = 0.32
Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 26/159 (16%)
Query: 217 PANGTDIVYDMKRGFVYLQPHSEHQ--GVVYCRAE-AGGRSQISVKYQLLYVAVPSGPPS 273
P +G + + ++ L + E Q G C AE A GR++ V +L + P
Sbjct: 2795 PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL------PV 2848
Query: 274 TTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGH 333
T L ++ GD + + C G P + +T ++RPVT G
Sbjct: 2849 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT------VNDRPVTE-----------GV 2891
Query: 334 TTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+ + S + D+G Y+C A+N G+T + V
Sbjct: 2892 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFV 2930
Score = 31.6 bits (70), Expect = 1.2
Identities = 14/32 (43%), Positives = 20/32 (62%)
Query: 342 ITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
+ ++ T D+G Y CTA+N G T+VA VE
Sbjct: 2355 LQLQALSTADSGDYSCTARNAAGSTSVAFRVE 2386
Score = 30.8 bits (68), Expect = 2.1
Identities = 31/136 (22%), Positives = 52/136 (38%), Gaps = 26/136 (19%)
Query: 242 GVVYCRA-EAGGRSQISVKYQLL----YVAVPSGPPSTTILASSNKVKSGDDISVLCTVL 296
G+ C A A GR Q V+ +L + P GP + V+ GD + C
Sbjct: 1722 GMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVL------VRVGDKAVLSCETD 1775
Query: 297 GEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYI 356
P+ V TW KD +P+ + + + G + +++ + D G Y
Sbjct: 1776 ALPEPTV--TWY----KDGQPLVLAQRTQALRGG---------QRLEIQEAQVSDKGLYS 1820
Query: 357 CTAQNLQGQTTVATTV 372
C N+ G+ T+
Sbjct: 1821 CKVSNVAGEAVRTFTL 1836
Score = 30.8 bits (68), Expect = 2.1
Identities = 46/217 (21%), Positives = 78/217 (35%), Gaps = 27/217 (12%)
Query: 151 YICR-KDEAKTGSTYIFFTEKGELFV-PSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLH 208
Y C ++ A ++F T + V P PS VV + + ++PC + +
Sbjct: 2643 YTCSARNSAGVAHKHVFLTVQASPVVKPLPS---VVRAVAEEEVLLPCEASGIPRPTITW 2699
Query: 209 REFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVP 268
++ T ++ + + P E G C A+ S + ++ V
Sbjct: 2700 QKEGLNVATGVSTQVLPGGQLRIAHASP--EDAGNYLCIAKNSAGSAMGKTRLVVQV--- 2754
Query: 269 SGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIH 328
PP G + C G P+ + TW KD +PV+ +
Sbjct: 2755 --PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNI--TW----DKDGQPVSGAE------ 2800
Query: 329 RGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQ 365
G T + V++ E DAG Y CTA+N G+
Sbjct: 2801 ---GKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGR 2834
>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
sapiens]
Length = 972
Score = 48.5 bits (114), Expect = 1e-05
Identities = 72/292 (24%), Positives = 114/292 (39%), Gaps = 55/292 (18%)
Query: 89 GQTVELRCKGS-RIGWSYPA--YLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWV 145
G TV LRC G+ + W P + + D S+ L+ N+T +TG + C
Sbjct: 35 GATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSI--------LSTNNATFQNTGTYRC-- 84
Query: 146 QLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPS-----YFDVVYLNPDRQAVVPCRVT- 199
+ GS I L+V P+ V + D+ A++PC +T
Sbjct: 85 -------TEPGDPLGGSAAI------HLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTD 131
Query: 200 -VLSAKVTLHREFPAKEIPA-NGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQIS 257
VL A V+L R + P T+ + GF + C A GGR +S
Sbjct: 132 PVLEAGVSLVR---VRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMS 188
Query: 258 VKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERP 317
+ +L V GPP+ T++ + G+ ++C+ V+V F +
Sbjct: 189 ISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSA---SSVDVNFDVFLQHNNTKLA 245
Query: 318 VTIQDTWRLIHRGLGHTTRISQSVITVE----DFETIDAGYYICTAQNLQGQ 365
+ Q + H R Q V+T+ DF+ AG Y C A N+QG+
Sbjct: 246 IPQQSDF--------HNNRY-QKVLTLNLDQVDFQ--HAGNYSCVASNVQGK 286
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 44.7 bits (104), Expect = 1e-04
Identities = 68/302 (22%), Positives = 109/302 (36%), Gaps = 51/302 (16%)
Query: 85 SLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYG-QLTLVNSTSADTGEFSC 143
S+ GQT++L C + S A + ++ + +G +L L + AD+GE+ C
Sbjct: 2061 SVTEGQTLDLNCV---VAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVC 2117
Query: 144 WVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNP-----------DRQA 192
V+ SG EA + + T G + P P + + P D
Sbjct: 2118 RVENGSG----PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNC 2173
Query: 193 VVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYL-QPHSEHQGVVYCR-AEA 250
VVP + A+VT H+ +PA + + L Q G C
Sbjct: 2174 VVPGQA---HAQVTWHKR--GGSLPAR-----HQTHGSLLRLHQVTPADSGEYVCHVVGT 2223
Query: 251 GGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFP 310
G + SV + +P P I +SS+ V G + + C V G+ +V
Sbjct: 2224 SGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQV------- 2276
Query: 311 GQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQN-LQGQTTVA 369
TW L ++ S + + DAG Y+C A N ++ TV
Sbjct: 2277 ------------TWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVT 2324
Query: 370 TT 371
T
Sbjct: 2325 VT 2326
Score = 40.0 bits (92), Expect = 0.003
Identities = 66/299 (22%), Positives = 116/299 (38%), Gaps = 52/299 (17%)
Query: 81 AATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGE 140
A++ + GQT++L C G ++ + L + QL L + AD+GE
Sbjct: 2931 ASSSHVTEGQTLDLNCVVP--GQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGE 2988
Query: 141 FSCWVQLCSGYICRKDEAKT-------GSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAV 193
+ C + SG ++ + T GS+Y + + PS + + + A
Sbjct: 2989 YVC--RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSST------VQQGQDAS 3040
Query: 194 VPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGG- 252
C + +A ++L + +E+ N V++ P+ +V R G
Sbjct: 3041 FKCLIHDGAAPISLEWKTRNQELEDN------------VHISPNGSIITIVGTRPSNHGT 3088
Query: 253 -RSQISVKYQLLYVAVP---SGPPSTTILASSNK-VKSGDDISVLCTVLGEPDVEVEFTW 307
R S Y + V GPP+ ++L VK G +++ C GEP +T
Sbjct: 3089 YRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR 3148
Query: 308 IF--PGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQG 364
I P + ++R + D S +V+ + + DAG Y+C AQN G
Sbjct: 3149 ISSTPAKLEQRTYGLMD---------------SHAVLQISSAKPSDAGTYVCLAQNALG 3192
Score = 39.3 bits (90), Expect = 0.006
Identities = 34/133 (25%), Positives = 54/133 (40%), Gaps = 25/133 (18%)
Query: 242 GVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILAS-SNKVKSGDDISVLCTVLGEPD 300
GV C +S S + +LL PS P + T+ S V+ G D++ +CT
Sbjct: 1742 GVYICTCRNLHQSNTS-RAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTA----- 1795
Query: 301 VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRIS-QSVITVEDFETIDAGYYICTA 359
K + P W +H G T + ++T+ + + DAG Y+CT
Sbjct: 1796 ------------KSKSPAYTL-VWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTG 1842
Query: 360 QNL----QGQTTV 368
N+ QG T+
Sbjct: 1843 SNMFAMDQGTATL 1855
Score = 38.1 bits (87), Expect = 0.013
Identities = 40/127 (31%), Positives = 51/127 (40%), Gaps = 24/127 (18%)
Query: 241 QGVVYCRAEAG-GRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEP 299
QG C+A G++Q S QL+ A+PS I S V G + C LG+P
Sbjct: 3461 QGTYICQAHGPWGKAQASA--QLVIQALPS--VLINIRTSVQTVVVGHAVEFECLALGDP 3516
Query: 300 DVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTA 359
+V TW G RP +Q S V+ + E DAG Y CTA
Sbjct: 3517 KPQV--TWSKVGGH-LRPGIVQ----------------SGGVVRIAHVELADAGQYRCTA 3557
Query: 360 QNLQGQT 366
N G T
Sbjct: 3558 TNAAGTT 3564
Score = 36.2 bits (82), Expect = 0.049
Identities = 65/300 (21%), Positives = 102/300 (34%), Gaps = 66/300 (22%)
Query: 89 GQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTS-ADTGEFSCWVQL 147
GQT++L+C + A + K +++ +G L +N S AD+GE+SC V
Sbjct: 2841 GQTLDLKCV---VPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTG 2897
Query: 148 CSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTL 207
SG + S + +P+P +Y+ V + L+ V
Sbjct: 2898 SSGTL-------EASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVV-- 2948
Query: 208 HREFPAKEIPANGTDIVYDMKRGFVYLQPHSEH-------------QGVVYCRAEAGGRS 254
P V KRG H H G CRA +G
Sbjct: 2949 ---------PGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGP 2999
Query: 255 QISVKYQLLYVAVPSGPPSTTILAS--------SNKVKSGDDISVLCTVLGEPDVEVEFT 306
+ + V VP S+ L S S+ V+ G D S C +
Sbjct: 3000 EQEASFT---VTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLI----------- 3045
Query: 307 WIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQ--SVITVEDFETIDAGYYICTAQNLQG 364
P++++ W+ ++ L IS S+IT+ + G Y C A N G
Sbjct: 3046 -----HDGAAPISLE--WKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYG 3098
Score = 34.3 bits (77), Expect = 0.19
Identities = 31/132 (23%), Positives = 49/132 (37%), Gaps = 21/132 (15%)
Query: 242 GVVYCRAEA-GGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPD 300
G C A + G +Q ++ +L A + PP I +SS V G + + C V G
Sbjct: 2021 GFYLCVATSPAGTAQARIQVVVLS-ASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAH 2079
Query: 301 VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQ 360
+V TW L T++ S + + D+G Y+C +
Sbjct: 2080 AQV-------------------TWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVE 2120
Query: 361 NLQGQTTVATTV 372
N G + TV
Sbjct: 2121 NGSGPKEASITV 2132
Score = 33.1 bits (74), Expect = 0.42
Identities = 58/292 (19%), Positives = 95/292 (32%), Gaps = 53/292 (18%)
Query: 85 SLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCW 144
S+ G V C +Y + +L + + G LT+ N +D G + C
Sbjct: 1782 SVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVC- 1840
Query: 145 VQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVP-------CR 197
+ D+ G+ + G L P VV ++P + V P C
Sbjct: 1841 ---TGSNMFAMDQ---GTATLHVQASGTLSAP------VVSIHPPQLTVQPGQLAEFRCS 1888
Query: 198 VTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSE--HQGVVYCRAEAGGRSQ 255
T P ++PA G + P E Q CRA + Q
Sbjct: 1889 ATGSPTPTLEWTGGPGGQLPAKA------QIHGGILRLPAVEPTDQAQYLCRAHSSAGQQ 1942
Query: 256 ISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDE 315
++ +L+V G P + +V +G + + C G P +
Sbjct: 1943 VA--RAVLHVH-GGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI------------ 1987
Query: 316 RPVTIQDTWRLIHRGL---GHTTRISQSVITVEDFETIDAGYYICTAQNLQG 364
TWR L + R + + + T DAG+Y+C A + G
Sbjct: 1988 -------TWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAG 2032
Score = 32.3 bits (72), Expect = 0.71
Identities = 28/127 (22%), Positives = 45/127 (35%), Gaps = 28/127 (22%)
Query: 249 EAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWI 308
EA G S + +V P G P I SS++V G + + C V G+ +V
Sbjct: 2811 EASGSSAV-------HVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQV----- 2858
Query: 309 FPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQG--QT 366
TW L ++ ++ + D+G Y C G +
Sbjct: 2859 --------------TWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEA 2904
Query: 367 TVATTVE 373
+V T+E
Sbjct: 2905 SVLVTIE 2911
Score = 32.0 bits (71), Expect = 0.93
Identities = 33/145 (22%), Positives = 50/145 (34%), Gaps = 30/145 (20%)
Query: 242 GVVYCRAEAG-GRSQISVKYQLL--------YVAVPSGPPSTTILASSNKVKSGDDISVL 292
G CR E G G + S+ +L Y VP I SS+ V G + +
Sbjct: 2113 GEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLN 2172
Query: 293 CTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDA 352
C V G+ +V TW L + S++ + D+
Sbjct: 2173 CVVPGQAHAQV-------------------TWHKRGGSLPARHQTHGSLLRLHQVTPADS 2213
Query: 353 GYYICTAQNLQG--QTTVATTVEFS 375
G Y+C G + +V T+E S
Sbjct: 2214 GEYVCHVVGTSGPLEASVLVTIEAS 2238
Score = 31.6 bits (70), Expect = 1.2
Identities = 13/43 (30%), Positives = 23/43 (53%)
Query: 323 TWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQ 365
+W + L +R+ +++ + DAG Y+CTA N QG+
Sbjct: 3607 SWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
Score = 29.6 bits (65), Expect = 4.6
Identities = 27/85 (31%), Positives = 34/85 (40%), Gaps = 16/85 (18%)
Query: 283 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI 342
V G S+ C V G P F W ++D RPV R H+G S +
Sbjct: 1688 VPQGGSHSLRCQVSGSPPHY--FYW---SREDGRPVPSGTQQR--HQG---------SEL 1731
Query: 343 TVEDFETIDAGYYICTAQNLQGQTT 367
+ DAG YICT +NL T
Sbjct: 1732 HFPSVQPSDAGVYICTCRNLHQSNT 1756
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 42.7 bits (99), Expect = 5e-04
Identities = 70/326 (21%), Positives = 124/326 (38%), Gaps = 50/326 (15%)
Query: 65 QSIMMQVLDKGRFQKPAAT-LSLLAGQTVELRCKGS-----RIGWSYPAYLDTFKDSRLS 118
Q +++ ++K F P + ++ +AG T+ L C + + W P D +L
Sbjct: 2532 QLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQ 2591
Query: 119 VKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSP 178
++ G L + +S D G + C + +G+ R K G K E +
Sbjct: 2592 RFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGL-------KPEA---NK 2641
Query: 179 SYFDVVYLNPDRQAVVPCRVTVL-------SAKVTLHREFPAK----EIPANGTDIVYDM 227
Y ++V + +PC + +H E P + NGT V
Sbjct: 2642 QYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTV--- 2698
Query: 228 KRGFVYLQPHSEHQGVVYCRAEAG-GRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSG 286
+ V+ +G CR E G S S+ ++ +A P P T+ + G
Sbjct: 2699 REASVF------DRGTYVCRMETEYGPSVTSIP--VIVIAYP--PRITSEPTPVIYTRPG 2748
Query: 287 DDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVED 346
+ + + C +G P ++ TW P K +Q R G+ Q +T++
Sbjct: 2749 NTVKLNCMAMGIPKADI--TWELP-DKSHLKAGVQA------RLYGNRFLHPQGSLTIQH 2799
Query: 347 FETIDAGYYICTAQNLQGQTTVATTV 372
DAG+Y C A+N+ G + T +
Sbjct: 2800 ATQRDAGFYKCMAKNILGSDSKTTYI 2825
Score = 37.7 bits (86), Expect = 0.017
Identities = 33/133 (24%), Positives = 53/133 (39%), Gaps = 17/133 (12%)
Query: 242 GVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDV 301
G+ C A+ R ++ + V PS P+ + K G+ +++ C L P
Sbjct: 551 GLYQCIAQV--RDEMDRMVYRVLVQSPSTQPAEKDTVTIGK-NPGESVTLPCNALAIP-- 605
Query: 302 EVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQN 361
E +WI P ++ I D H + +++ + D+GYY C A N
Sbjct: 606 EAHLSWILPNRR-----IINDL-----ANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVN 655
Query: 362 LQG--QTTVATTV 372
QG TV TV
Sbjct: 656 QQGADHFTVGITV 668
Score = 37.0 bits (84), Expect = 0.029
Identities = 21/84 (25%), Positives = 37/84 (44%), Gaps = 11/84 (13%)
Query: 286 GDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVE 345
GD I++ C G P ++ +WIFP ++ W+ + G T ++++
Sbjct: 1965 GDTIAMECLAKGTPAPQI--SWIFPDRR---------VWQTVSPVEGRITLHENRTLSIK 2013
Query: 346 DFETIDAGYYICTAQNLQGQTTVA 369
+ D G Y C A N G ++A
Sbjct: 2014 EASFSDRGVYKCVASNAAGADSLA 2037
Score = 35.8 bits (81), Expect = 0.064
Identities = 70/296 (23%), Positives = 116/296 (39%), Gaps = 49/296 (16%)
Query: 89 GQTVELRCKGS-----RIGWSYPAY-----LDTFKDSRLSVKQNERYGQLTLVNSTSADT 138
G T++L C S RI W P+ L +F DSR+ V N G L + + T D
Sbjct: 2161 GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSF-DSRIKVFAN---GTLVVKSVTDKDA 2216
Query: 139 GEFSCWVQLCSG--YICRKDEAKTGSTYIFFTEKGE--LFVPSPSYFDVVYL---NPDRQ 191
G++ C + G Y+ K + I E+ + +F D V NP+
Sbjct: 2217 GDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEIS 2276
Query: 192 AVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYL-QPHSEHQGVVYCRAEA 250
+P +L F + T G +Y + +G C AE
Sbjct: 2277 WSLP--------DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAEN 2328
Query: 251 G-GRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIF 309
G+ ++ V+ ++ V P+ + T LA +V GD ++V C GEP +V TW+
Sbjct: 2329 QVGKDEMRVRVKV--VTAPATIRNKTYLAV--QVPYGDVVTVACEAKGEPMPKV--TWLS 2382
Query: 310 PGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQ 365
P K T + +++ G + ++ + D+G Y C +N G+
Sbjct: 2383 PTNK--VIPTSSEKYQIYQDG----------TLLIQKAQRSDSGNYTCLVRNSAGE 2426
Score = 29.3 bits (64), Expect = 6.0
Identities = 26/103 (25%), Positives = 40/103 (38%), Gaps = 15/103 (14%)
Query: 270 GPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHR 329
GPP++ + K + +V E D +FP + +P TW +
Sbjct: 1840 GPPASKFWSLGEKPQILTKSPQTVSVTAETDT------VFPCEATGKPKPFV-TWTKVST 1892
Query: 330 GLGHT--TRISQ------SVITVEDFETIDAGYYICTAQNLQG 364
G T TRI + + + + D G Y+CTA NL G
Sbjct: 1893 GALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHG 1935
>gi|116008194 myosin light chain kinase isoform 3A [Homo sapiens]
Length = 1863
Score = 41.6 bits (96), Expect = 0.001
Identities = 85/372 (22%), Positives = 134/372 (36%), Gaps = 72/372 (19%)
Query: 31 KEPGENRIKPTNKKVKPKIPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQ 90
++PG +K +IP RDSA PK +S KP + + Q
Sbjct: 385 RQPGLGSQDVVSKAANRRIPMEGQRDSA--FPKFES------------KPQSQ-EVKENQ 429
Query: 91 TVELRCKGS-----RIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWV 145
TV+ RC+ S + W ++ + V ++ L L+ + + D+G +SC
Sbjct: 430 TVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTA 489
Query: 146 QLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKV 205
G + ++ E+ + +PS+ V+ AV+ + VL V
Sbjct: 490 SNAQGQL--------SCSWTLQVERLAVMEVAPSFSSVL----KDCAVIEGQDFVLQCSV 537
Query: 206 TLHREFPAKEIP--ANGTDIVY---DMKRGFVYLQPHS---EHQGVVYCRAE-AGGRSQI 256
R P I NG I Y + G L E G C AE A G+
Sbjct: 538 ---RGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSC 594
Query: 257 SV-----------KYQLLYVAVPSGPPSTTIL--ASSNKVKSGDDISVLCTVLGEPDVEV 303
S K + L PS P + L S KV G +++ V G P EV
Sbjct: 595 SAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEV 654
Query: 304 EFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQ 363
W+ G + + + + RG H+ + +++ D G Y C A N
Sbjct: 655 --IWLHNGNE----IQESEDFHFEQRGTQHS-------LCIQEVFPEDTGTYTCEAWNSA 701
Query: 364 GQ--TTVATTVE 373
G+ T TV+
Sbjct: 702 GEVRTQAVLTVQ 713
>gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens]
Length = 1914
Score = 41.6 bits (96), Expect = 0.001
Identities = 85/372 (22%), Positives = 134/372 (36%), Gaps = 72/372 (19%)
Query: 31 KEPGENRIKPTNKKVKPKIPKMKDRDSANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQ 90
++PG +K +IP RDSA PK +S KP + + Q
Sbjct: 385 RQPGLGSQDVVSKAANRRIPMEGQRDSA--FPKFES------------KPQSQ-EVKENQ 429
Query: 91 TVELRCKGS-----RIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWV 145
TV+ RC+ S + W ++ + V ++ L L+ + + D+G +SC
Sbjct: 430 TVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTA 489
Query: 146 QLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKV 205
G + ++ E+ + +PS+ V+ AV+ + VL V
Sbjct: 490 SNAQGQL--------SCSWTLQVERLAVMEVAPSFSSVL----KDCAVIEGQDFVLQCSV 537
Query: 206 TLHREFPAKEIP--ANGTDIVY---DMKRGFVYLQPHS---EHQGVVYCRAE-AGGRSQI 256
R P I NG I Y + G L E G C AE A G+
Sbjct: 538 ---RGTPVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSC 594
Query: 257 SV-----------KYQLLYVAVPSGPPSTTIL--ASSNKVKSGDDISVLCTVLGEPDVEV 303
S K + L PS P + L S KV G +++ V G P EV
Sbjct: 595 SAWVTVHEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEV 654
Query: 304 EFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQ 363
W+ G + + + + RG H+ + +++ D G Y C A N
Sbjct: 655 --IWLHNGNE----IQESEDFHFEQRGTQHS-------LCIQEVFPEDTGTYTCEAWNSA 701
Query: 364 GQ--TTVATTVE 373
G+ T TV+
Sbjct: 702 GEVRTQAVLTVQ 713
>gi|144226847 obscurin-like 1 [Homo sapiens]
Length = 1896
Score = 40.4 bits (93), Expect = 0.003
Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 12/87 (13%)
Query: 283 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI 342
V G C V+G+P+ E+E+ W + RP+ + D RL++R R V+
Sbjct: 257 VNEGKHAKFRCYVMGKPEPEIEWHW------EGRPL-LPDRRRLMYRD-----RDGGFVL 304
Query: 343 TVEDFETIDAGYYICTAQNLQGQTTVA 369
V + D G Y+C A+N GQT A
Sbjct: 305 KVLYCQAKDRGLYVCAARNSAGQTLSA 331
Score = 33.5 bits (75), Expect = 0.32
Identities = 28/102 (27%), Positives = 41/102 (40%), Gaps = 13/102 (12%)
Query: 271 PPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRG 330
PP +V SG + + C VLGEP V W GQ+ + + G
Sbjct: 11 PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVV--VWEKGGQQ----LAASERLSFPADG 64
Query: 331 LGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
H ++ ++ T DAG Y+C A+N G+ A V
Sbjct: 65 AEHGLLLTAALPT-------DAGVYVCRARNAAGEAYAAAAV 99
Score = 32.7 bits (73), Expect = 0.55
Identities = 64/277 (23%), Positives = 109/277 (39%), Gaps = 41/277 (14%)
Query: 92 VELRCK----GSRIGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQL 147
VELRC+ GS++ W Y L+ L + LTL ++ D GE+ C
Sbjct: 1099 VELRCEVAPAGSQVRW-YKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCET-- 1155
Query: 148 CSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTL 207
+ EA T + + E F+ + + + P V+ C ++ A V
Sbjct: 1156 -------RHEAITFN--VILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVW 1206
Query: 208 -HREFPAKEIPANGTDIVYDMKRGFVYLQPHSE-HQGVVYCRAEAG-GRSQISVKYQLLY 264
H P +E G ++ + R + +Q H G+ C++ A G +S Q+
Sbjct: 1207 SHNGRPVQE--GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAE 1264
Query: 265 VAVPSGPPSTTILASSNKVKS--GDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQD 322
V P A+ +V+S G D+ ++ + G P V + KD + Q
Sbjct: 1265 PPVRVVAPE----AAQTRVRSTPGGDLELVVHLSG-PGGPVRW------YKDGERLASQG 1313
Query: 323 TWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTA 359
+L G ++ V+ V+ + DAG Y+C A
Sbjct: 1314 RVQLEQAG-------ARQVLRVQGARSGDAGEYLCDA 1343
Score = 30.4 bits (67), Expect = 2.7
Identities = 65/297 (21%), Positives = 106/297 (35%), Gaps = 45/297 (15%)
Query: 83 TLSLLAGQTVELRCKGSRIGWSYPAYLDTFK---DSRLSVKQNERYGQLTLVNSTSADTG 139
+L+ + V L C+ SR+ + Y D K L VK + R +L L + D+G
Sbjct: 725 SLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSG 784
Query: 140 EFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVT 199
EF C + S + G T + + + P V+ ++ C V
Sbjct: 785 EFECRTEGVSAFF--------GVT----VQDPPVHIVDPREHVFVHAITSECVMLACEVD 832
Query: 200 VLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVY--CRAEAGGRSQIS 257
A V +++ E + FV L+ H+ +V + GG Q
Sbjct: 833 REDAPVRWYKDGQEVE------------ESDFVVLENEGPHRRLVLPATQPSDGGEFQCV 880
Query: 258 VKYQLLYVAVPSGPPSTTILASSNKVKSGD---DISVLCTVLGEPDVEVEFTWIFPGQKD 314
+ Y V S+ I+ S KV + VL L P EV +T KD
Sbjct: 881 AGDECAYFTVTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWT------KD 934
Query: 315 ERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATT 371
V ++ L+ + R+ + +E D+G Y+C + TV T
Sbjct: 935 GEEVV--ESPALLLQKEDTVRRLVLPAVQLE-----DSGEYLCEIDDESASFTVTVT 984
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 40.0 bits (92), Expect = 0.003
Identities = 27/105 (25%), Positives = 47/105 (44%), Gaps = 13/105 (12%)
Query: 269 SGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIH 328
SG P + V G D ++ C ++G P +V + +KD++PV +RL
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSW------EKDQQPVAAGARFRLAQ 60
Query: 329 RGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
G + +T+ D D+G Y+C A+N G+ A ++
Sbjct: 61 DGDLYR-------LTILDLALGDSGQYVCRARNAIGEAFAAVGLQ 98
Score = 35.8 bits (81), Expect = 0.064
Identities = 60/275 (21%), Positives = 98/275 (35%), Gaps = 33/275 (12%)
Query: 88 AGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYG---QLTLVNSTSADTGEFSCW 144
AG + L C+ ++ Y D K S S E G +L L + AD GE+SC
Sbjct: 1088 AGASAMLSCEVAQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSC- 1146
Query: 145 VQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAK 204
+ + S ++ TE +F S + V A++ C V +
Sbjct: 1147 ----------EAGGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTE 1196
Query: 205 VTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLY 264
VT +++ + V R V Q G C EAGG+ V +QL
Sbjct: 1197 VTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSC--EAGGQ---RVSFQLHI 1251
Query: 265 VAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTW 324
+ ++ + + ++G ++ C V + E TW KD + ++
Sbjct: 1252 TEPKAVFAKEQLVHNEVRTEAGASATLSCEV---AQAQTEVTW----YKDGKKLSSSSKV 1304
Query: 325 RLIHRGLGHTTRISQSVITVEDFETIDAGYYICTA 359
R+ G + V+ DAG Y C A
Sbjct: 1305 RIEAAG-------CMRQLVVQQAGQADAGEYTCEA 1332
Score = 34.3 bits (77), Expect = 0.19
Identities = 31/102 (30%), Positives = 39/102 (38%), Gaps = 20/102 (19%)
Query: 268 PSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQ---KDERPVTIQDTW 324
P+ PPST + V G + C V GEP E W GQ + R V +D
Sbjct: 236 PASPPSTGTRTCT--VTEGKHARLSCYVTGEPKPET--VWKKDGQLVTEGRRHVVYEDAQ 291
Query: 325 RLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQT 366
V+ + + D G Y CTA NL GQT
Sbjct: 292 E-------------NFVLKILFCKQSDRGLYTCTASNLVGQT 320
Score = 29.6 bits (65), Expect = 4.6
Identities = 21/76 (27%), Positives = 38/76 (50%), Gaps = 13/76 (17%)
Query: 79 KPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERY--------GQLTL 130
KP + G+ VELRC+ SR G + KD R +++++++Y L +
Sbjct: 2831 KPLEDQWVAPGEDVELRCELSRAG----TPVHWLKD-RKAIRKSQKYDVVCEGTMAMLVI 2885
Query: 131 VNSTSADTGEFSCWVQ 146
++ D GE++C V+
Sbjct: 2886 RGASLKDAGEYTCEVE 2901
>gi|148833506 obscurin, cytoskeletal calmodulin and
titin-interacting RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 40.0 bits (92), Expect = 0.003
Identities = 27/105 (25%), Positives = 47/105 (44%), Gaps = 13/105 (12%)
Query: 269 SGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIH 328
SG P + V G D ++ C ++G P +V + +KD++PV +RL
Sbjct: 7 SGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSW------EKDQQPVAAGARFRLAQ 60
Query: 329 RGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
G + +T+ D D+G Y+C A+N G+ A ++
Sbjct: 61 DGDLYR-------LTILDLALGDSGQYVCRARNAIGEAFAAVGLQ 98
Score = 35.8 bits (81), Expect = 0.064
Identities = 60/275 (21%), Positives = 98/275 (35%), Gaps = 33/275 (12%)
Query: 88 AGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERYG---QLTLVNSTSADTGEFSCW 144
AG + L C+ ++ Y D K S S E G +L L + AD GE+SC
Sbjct: 1088 AGASAMLSCEVAQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSC- 1146
Query: 145 VQLCSGYICRKDEAKTGSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAK 204
+ + S ++ TE +F S + V A++ C V +
Sbjct: 1147 ----------EAGGQRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVAQPQTE 1196
Query: 205 VTLHREFPAKEIPANGTDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLY 264
VT +++ + V R V Q G C EAGG+ V +QL
Sbjct: 1197 VTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSC--EAGGQ---RVSFQLHI 1251
Query: 265 VAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTW 324
+ ++ + + ++G ++ C V + E TW KD + ++
Sbjct: 1252 TEPKAVFAKEQLVHNEVRTEAGASATLSCEV---AQAQTEVTW----YKDGKKLSSSSKV 1304
Query: 325 RLIHRGLGHTTRISQSVITVEDFETIDAGYYICTA 359
R+ G + V+ DAG Y C A
Sbjct: 1305 RIEAAG-------CMRQLVVQQAGQADAGEYTCEA 1332
Score = 34.3 bits (77), Expect = 0.19
Identities = 31/102 (30%), Positives = 39/102 (38%), Gaps = 20/102 (19%)
Query: 268 PSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQ---KDERPVTIQDTW 324
P+ PPST + V G + C V GEP E W GQ + R V +D
Sbjct: 236 PASPPSTGTRTCT--VTEGKHARLSCYVTGEPKPET--VWKKDGQLVTEGRRHVVYEDAQ 291
Query: 325 RLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQT 366
V+ + + D G Y CTA NL GQT
Sbjct: 292 E-------------NFVLKILFCKQSDRGLYTCTASNLVGQT 320
Score = 30.8 bits (68), Expect = 2.1
Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 13/95 (13%)
Query: 271 PPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRG 330
PPS + + ++G + G+P V TW KD V + D+ RL +
Sbjct: 6356 PPSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSV--TWY----KDS--VQLVDSTRLSQQQ 6407
Query: 331 LGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQ 365
G T + + + DAG Y C AQN GQ
Sbjct: 6408 EGTTYSL-----VLRHVASKDAGVYTCLAQNTGGQ 6437
Score = 29.6 bits (65), Expect = 4.6
Identities = 21/76 (27%), Positives = 38/76 (50%), Gaps = 13/76 (17%)
Query: 79 KPAATLSLLAGQTVELRCKGSRIGWSYPAYLDTFKDSRLSVKQNERY--------GQLTL 130
KP + G+ VELRC+ SR G + KD R +++++++Y L +
Sbjct: 2831 KPLEDQWVAPGEDVELRCELSRAG----TPVHWLKD-RKAIRKSQKYDVVCEGTMAMLVI 2885
Query: 131 VNSTSADTGEFSCWVQ 146
++ D GE++C V+
Sbjct: 2886 RGASLKDAGEYTCEVE 2901
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 40.0 bits (92), Expect = 0.003
Identities = 36/118 (30%), Positives = 55/118 (46%), Gaps = 17/118 (14%)
Query: 258 VKYQLLYVAVPSGPPSTTILASSNKVKS--GDDISVLCTVLGEPDVEVEFTWIFP-GQKD 314
+ + LL + V SG + S +KV+ G+ CT +GEP+ W P G+K
Sbjct: 5 LSFYLLGLLVSSGQALLQVTISLSKVELSVGESKFFTCTAIGEPE---SIDWYNPQGEK- 60
Query: 315 ERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTV 372
I T R++ + G +R+ T+ + DAG Y C A + +GQT AT V
Sbjct: 61 -----IISTQRVVVQKEGVRSRL-----TIYNANIEDAGIYRCQATDAKGQTQEATVV 108
Score = 39.3 bits (90), Expect = 0.006
Identities = 53/267 (19%), Positives = 92/267 (34%), Gaps = 30/267 (11%)
Query: 101 IGWSYPAYLDTFKDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKT 160
I W P R+ V++ +LT+ N+ D G + C G
Sbjct: 51 IDWYNPQGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLE 110
Query: 161 GSTYIFFTEKGELFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANG 220
+ F E V SP F A V CRV+ A + +
Sbjct: 111 IYQKLTFRE-----VVSPQEF-----KQGEDAEVVCRVSSSPAPAVSWLYHNEEVTTISD 160
Query: 221 TDIVYDMKRGFVYLQPHSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSG--PPSTTILA 278
L + +G+ C R +I + ++ V VP P + A
Sbjct: 161 NRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNA 220
Query: 279 SSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRIS 338
++ + G++++ C G P+ + +W G+ I++ + I +G S
Sbjct: 221 TAER---GEEMTFSCRASGSPEPAI--SWFRNGK------LIEENEKYILKG-------S 262
Query: 339 QSVITVEDFETIDAGYYICTAQNLQGQ 365
+ +TV + D G Y+C A N G+
Sbjct: 263 NTELTVRNIINSDGGPYVCRATNKAGE 289
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 39.3 bits (90), Expect = 0.006
Identities = 75/330 (22%), Positives = 119/330 (36%), Gaps = 54/330 (16%)
Query: 58 ANSAPKTQSIMMQVLDKGRFQKPAATLSLLAGQTVELRCKGS-----RIGWSYPAYLDTF 112
A + KT S+++ VL Q LS + G V L CK S + WS L +
Sbjct: 966 AGTNNKTTSVVVHVLPT--IQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELIST 1023
Query: 113 KDSRLSVKQNERYGQLTLVNSTSADTGEFSCWVQLCSGYICRKDEAKTGSTYIFFTEKGE 172
++ S + G L +V+ ++GE+ C +GY RK + F ++
Sbjct: 1024 SSAKFSAGAD---GSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRG 1080
Query: 173 LFVPSPSYFDVVYLNPDRQAVVPCRVTVLSAKVTLHREFPAKEIPANGTDIVYDMKRGFV 232
L P V+ + +PC V L + AKE T ++
Sbjct: 1081 LSQDKPVEISVL---AGEEVTLPCEVKSLPPPIITW----AKE-----TQLISPFSPRHT 1128
Query: 233 YL--------QPHSEHQGVVYCRAE--AGGRSQISVKYQLLYVAVPSGPPSTTILASSNK 282
+L + + G+ C A AG +Q +VK L V VP P K
Sbjct: 1129 FLPSGSMKITETRTSDSGMYLCVATNIAGNVTQ-AVK---LNVHVP---PKIQRGPKHLK 1181
Query: 283 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI 342
V+ G + + C G P + TW G ++ G H + +
Sbjct: 1182 VQVGQRVDIPCNAQGTPLPVI--TWSKGGST------------MLVDGEHHVSN-PDGTL 1226
Query: 343 TVEDFETIDAGYYICTAQNLQGQTTVATTV 372
+++ DAG Y C A N+ G T+
Sbjct: 1227 SIDQATPSDAGIYTCVATNIAGTDETEITL 1256
Score = 36.6 bits (83), Expect = 0.038
Identities = 33/129 (25%), Positives = 53/129 (41%), Gaps = 17/129 (13%)
Query: 237 HSEHQGVVYCRAEAGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVL 296
HS+ + G++Q KY L + VP I S V G+++ ++C
Sbjct: 3216 HSDSGNYTCIASNMEGKAQ---KYYFLSIQVPPSVAGAEI-PSDVSVLLGENVELVCNAN 3271
Query: 297 GEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYI 356
G P ++ W+ KD +P+ +T R+ G T I ++ T D G Y
Sbjct: 3272 GIPTPLIQ--WL----KDGKPIASGETERIRVSANGSTLNIYGAL-------TSDTGKYT 3318
Query: 357 CTAQNLQGQ 365
C A N G+
Sbjct: 3319 CVATNPAGE 3327
Score = 35.4 bits (80), Expect = 0.084
Identities = 29/134 (21%), Positives = 54/134 (40%), Gaps = 23/134 (17%)
Query: 242 GVVYCRAEA-GGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPD 300
G +C + GG S SV ++ V PP T++ + G ++S++C+ G P
Sbjct: 587 GEYHCMVSSEGGSSAASV-----FLTVQE-PPKVTVMPKNQSFTGGSEVSIMCSATGYPK 640
Query: 301 VEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQ 360
++ + T+ D + + G S + +++ DAG Y C A
Sbjct: 641 PKIAW-------------TVNDMFIV---GSHRYRMTSDGTLFIKNAAPKDAGIYGCLAS 684
Query: 361 NLQGQTTVATTVEF 374
N G +T+ +
Sbjct: 685 NSAGTDKQNSTLRY 698
Score = 33.1 bits (74), Expect = 0.42
Identities = 27/102 (26%), Positives = 46/102 (45%), Gaps = 15/102 (14%)
Query: 272 PSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGL 331
P ++ S V GD + C G P +V++ F G + RP T+ +I L
Sbjct: 702 PKLMVVQSELLVALGDITVMECKTSGIPPPQVKW---FKGDLELRP----STFLIIDPLL 754
Query: 332 GHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
G ++ +++ + +DAG Y C A N G+ T T++
Sbjct: 755 G--------LLKIQETQDLDAGDYTCVAINEAGRATGKITLD 788
Score = 31.2 bits (69), Expect = 1.6
Identities = 23/84 (27%), Positives = 35/84 (41%), Gaps = 15/84 (17%)
Query: 283 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI 342
V G IS+ C V G P V TW+ KD P+ ++ G ++
Sbjct: 2304 VTRGKSISLECEVQGIPPPTV--TWM----KDGHPLIKAKGVEILDEG---------HIL 2348
Query: 343 TVEDFETIDAGYYICTAQNLQGQT 366
+++ D G Y+C A N+ G T
Sbjct: 2349 QLKNIHVSDTGRYVCVAVNVAGMT 2372
Score = 30.4 bits (67), Expect = 2.7
Identities = 12/29 (41%), Positives = 19/29 (65%)
Query: 338 SQSVITVEDFETIDAGYYICTAQNLQGQT 366
++SV+ +ED + D G Y C A N+ G+T
Sbjct: 2155 NRSVLKIEDAQVQDTGRYTCEATNVAGKT 2183
Score = 29.6 bits (65), Expect = 4.6
Identities = 22/79 (27%), Positives = 40/79 (50%), Gaps = 16/79 (20%)
Query: 289 ISVLCTVLGEPDVEVEFTWIFPGQKDERPV-TIQDTWRLIHRGLGHTTRISQSVITVEDF 347
+++ C G P+ + TW+ KD++PV T Q ++ + G +I+++++
Sbjct: 1844 VALQCIANGIPNPSI--TWL----KDDQPVNTAQGNLKI--QSSGRVLQIAKTLLE---- 1891
Query: 348 ETIDAGYYICTAQNLQGQT 366
DAG Y C A N G+T
Sbjct: 1892 ---DAGRYTCVATNAAGET 1907
Score = 29.3 bits (64), Expect = 6.0
Identities = 20/84 (23%), Positives = 36/84 (42%), Gaps = 15/84 (17%)
Query: 282 KVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSV 341
K+K + +++ C P + + KD +P+ D + G HT +I ++
Sbjct: 2685 KIKVNNTLTLECEAYAIPSASLSW------YKDGQPLKSDDHVNIAANG--HTLQIKEAQ 2736
Query: 342 ITVEDFETIDAGYYICTAQNLQGQ 365
I+ D G Y C A N+ G+
Sbjct: 2737 IS-------DTGRYTCVASNIAGE 2753
Score = 28.9 bits (63), Expect = 7.9
Identities = 43/201 (21%), Positives = 75/201 (37%), Gaps = 37/201 (18%)
Query: 176 PSPSYFDVVYLNPDRQAVVPCRVT-VLSAKVTLHREFPAKEIPANGTDIVYDMKRGFVYL 234
P PS V+ NP ++PC T S +T +E + +G + G
Sbjct: 3992 PQPSELHVILNNP---ILLPCEATGTPSPFITWQKE--GINVNTSGRNHAVLPSGGLQIS 4046
Query: 235 QPHSEHQGVVYCRAE-----AGGRSQISVKYQLLYVAVPSGPPSTTILASSNKVKSGDDI 289
+ E G C A+ A G+ +++V+ PP + + I
Sbjct: 4047 RAVREDAGTYMCVAQNPAGTALGKIKLNVQV----------PPVISPHLKEYVIAVDKPI 4096
Query: 290 SVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVITVEDFET 349
++ C G P ++ TW KD R + R++ G + + +
Sbjct: 4097 TLSCEADGLPPPDI--TW----HKDGRAIVESIRQRVLSSGS----------LQIAFVQP 4140
Query: 350 IDAGYYICTAQNLQGQTTVAT 370
DAG+Y C A N+ G ++ +T
Sbjct: 4141 GDAGHYTCMAANVAGSSSTST 4161
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 39.3 bits (90), Expect = 0.006
Identities = 23/91 (25%), Positives = 41/91 (45%), Gaps = 12/91 (13%)
Query: 283 VKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERPVTIQDTWRLIHRGLGHTTRISQSVI 342
V G + + C + EP+ E+ W+ P T+ D ++L S+ +
Sbjct: 437 VDIGTTVFLDCRAMAEPEPEIY--WVTPIGNKITVETLSDKYKLS----------SEGTL 484
Query: 343 TVEDFETIDAGYYICTAQNLQGQTTVATTVE 373
+ + + D+G Y C AQN+QG T T++
Sbjct: 485 EISNIQIEDSGRYTCVAQNVQGADTRVATIK 515
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 38.9 bits (89), Expect = 0.008
Identities = 28/113 (24%), Positives = 44/113 (38%), Gaps = 19/113 (16%)
Query: 258 VKYQLLYVAVPSGPPSTTILASSNKVKSGDDISVLCTVLGEPDVEVEFTWIFPGQKDERP 317
VK + V P T + S+ K G ++++ C V G P+ EV
Sbjct: 1273 VKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEV-------------- 1318
Query: 318 VTIQDTWRLIHRGLGHTTRISQSVITVEDFETIDAGYYICTAQNLQGQTTVAT 370
TW LG + + + + + + D G Y C A NL G+ T +T
Sbjct: 1319 -----TWFRNKSKLGSPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTEST 1366
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,763,700
Number of Sequences: 37866
Number of extensions: 678484
Number of successful extensions: 2950
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 2228
Number of HSP's gapped (non-prelim): 725
length of query: 375
length of database: 18,247,518
effective HSP length: 104
effective length of query: 271
effective length of database: 14,309,454
effective search space: 3877862034
effective search space used: 3877862034
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.