Guide to the Human Genome
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Search of human proteins with 51873047

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51873047 G protein-coupled receptor kinase 4 isoform gamma
[Homo sapiens]
         (532 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H...  1102   0.0  
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H...  1080   0.0  
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho...   997   0.0  
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]         762   0.0  
gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo ...   756   0.0  
gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo ...   756   0.0  
gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo ...   756   0.0  
gi|4506529 rhodopsin kinase [Homo sapiens]                            486   e-137
gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]        481   e-136
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]         308   6e-84
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]         298   1e-80
gi|47157325 protein kinase C, delta [Homo sapiens]                    209   4e-54
gi|31377782 protein kinase C, delta [Homo sapiens]                    209   4e-54
gi|4506067 protein kinase C, alpha [Homo sapiens]                     206   6e-53
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           206   6e-53
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           206   6e-53
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                205   1e-52
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                205   1e-52
gi|5453974 protein kinase N2 [Homo sapiens]                           204   2e-52
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       201   1e-51
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      201   1e-51
gi|28557781 protein kinase C, eta [Homo sapiens]                      201   2e-51
gi|4502023 AKT2 kinase [Homo sapiens]                                 199   7e-51
gi|62241015 AKT1 kinase [Homo sapiens]                                197   3e-50
gi|62241013 AKT1 kinase [Homo sapiens]                                197   3e-50
gi|62241011 AKT1 kinase [Homo sapiens]                                197   3e-50
gi|5453976 protein kinase C, theta [Homo sapiens]                     196   6e-50
gi|13384594 protein kinase C, gamma [Homo sapiens]                    194   1e-49
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   192   8e-49
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   186   4e-47

>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
           sapiens]
          Length = 532

 Score = 1102 bits (2849), Expect = 0.0
 Identities = 532/532 (100%), Positives = 532/532 (100%)

Query: 1   MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
           MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
Sbjct: 1   MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60

Query: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
           PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
Sbjct: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120

Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
           IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180

Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
           PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240

Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
           KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300

Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
           EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360

Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
           EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420

Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
           CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480

Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEGCLTMVPSEKEVEPKQC 532
           IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEGCLTMVPSEKEVEPKQC
Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEGCLTMVPSEKEVEPKQC 532


>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
           sapiens]
          Length = 578

 Score = 1080 bits (2792), Expect = 0.0
 Identities = 532/578 (92%), Positives = 532/578 (92%), Gaps = 46/578 (7%)

Query: 1   MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
           MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
Sbjct: 1   MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60

Query: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
           PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
Sbjct: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120

Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
           IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180

Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
           PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240

Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
           KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300

Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
           EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360

Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
           EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420

Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
           CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480

Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE------------------------- 515
           IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE                         
Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540

Query: 516 ---------------------GCLTMVPSEKEVEPKQC 532
                                GCLTMVPSEKEVEPKQC
Sbjct: 541 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 578


>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
           sapiens]
          Length = 546

 Score =  997 bits (2577), Expect = 0.0
 Identities = 500/578 (86%), Positives = 500/578 (86%), Gaps = 78/578 (13%)

Query: 1   MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
           MELENIVANSLLLKARQ                                EKDYSSLCDKQ
Sbjct: 1   MELENIVANSLLLKARQ--------------------------------EKDYSSLCDKQ 28

Query: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
           PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
Sbjct: 29  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 88

Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
           IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
Sbjct: 89  IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 148

Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
           PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
Sbjct: 149 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 208

Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
           KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
Sbjct: 209 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268

Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
           EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
Sbjct: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 328

Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
           EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
Sbjct: 329 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 388

Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
           CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
Sbjct: 389 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 448

Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE------------------------- 515
           IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE                         
Sbjct: 449 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 508

Query: 516 ---------------------GCLTMVPSEKEVEPKQC 532
                                GCLTMVPSEKEVEPKQC
Sbjct: 509 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 546


>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
          Length = 590

 Score =  762 bits (1968), Expect = 0.0
 Identities = 362/515 (70%), Positives = 432/515 (83%), Gaps = 1/515 (0%)

Query: 1   MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
           MELENIVAN++LLKAR+GG GK+ G+SKKWKEIL  P +SQC +LR +I++DY SLCDKQ
Sbjct: 1   MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60

Query: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
           PIGR LFRQFC+T+P L+ +I+FLD+VAEYEV  DE   + G  I+ ++   K    + +
Sbjct: 61  PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120

Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
           +  D+V++    L ++ P K+ F  C +  H YLRGEPF EY +S +F +FLQWKWLERQ
Sbjct: 121 VGQDLVSQTEEKLLQK-PCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179

Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
           PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACK+L+KKRIKKRKGE+MALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239

Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
           KV S+FVV+LAYAYETKDALCLVLTIMNGGDLKFHIYN+GNPGF+E+RA+FYAAE+ CGL
Sbjct: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299

Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
           EDL RE  VYRDLKPENILLDD GHIRISDLGLA +IPEG  +RGRVGTVGYMAPEV+NN
Sbjct: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359

Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
           ++Y  SPD+WGLGCLIYEMI+G SPF+  KEKVK EEVD+R+    E YS KFSE+AKSI
Sbjct: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419

Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
           C+MLLTK+  +RLGC+ EGAA VK+HP F+++NF+RLEA ML+PPF PDP AVYCKDVLD
Sbjct: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479

Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE 515
           IEQFS VKG+ LD  D+DFY++F+TG VSIPWQNE
Sbjct: 480 IEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNE 514


>gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo
           sapiens]
          Length = 560

 Score =  756 bits (1951), Expect = 0.0
 Identities = 358/515 (69%), Positives = 420/515 (81%), Gaps = 1/515 (0%)

Query: 1   MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
           MELENIVAN++LLKAR+GG G + G+SKKW+++L  P +SQC ELR S+E+DY SLC++Q
Sbjct: 1   MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60

Query: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
           PIGR LFR+FC T+P L R + FLD VAEYEV  D+ R  CG  +   F +      +PE
Sbjct: 61  PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120

Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
           +P  +VT C   L E+ P K  F+E TR+ H YL   PF +Y +S YF++FLQWKWLERQ
Sbjct: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179

Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
           PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239

Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
           KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G  GF E RAVFYAAE+CCGL
Sbjct: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299

Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
           EDL RERIVYRDLKPENILLDD GHIRISDLGLA  +PEGQ ++GRVGTVGYMAPEVV N
Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359

Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
           E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K   EEYSE+FS  A+S+
Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419

Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
           C  LL K+P++RLGCRG  A  VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD
Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479

Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE 515
           IEQFS VKG+ L+  D+DFY +FATG V IPWQNE
Sbjct: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNE 514


>gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo
           sapiens]
          Length = 576

 Score =  756 bits (1951), Expect = 0.0
 Identities = 358/515 (69%), Positives = 420/515 (81%), Gaps = 1/515 (0%)

Query: 1   MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
           MELENIVAN++LLKAR+GG G + G+SKKW+++L  P +SQC ELR S+E+DY SLC++Q
Sbjct: 1   MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60

Query: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
           PIGR LFR+FC T+P L R + FLD VAEYEV  D+ R  CG  +   F +      +PE
Sbjct: 61  PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120

Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
           +P  +VT C   L E+ P K  F+E TR+ H YL   PF +Y +S YF++FLQWKWLERQ
Sbjct: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179

Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
           PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239

Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
           KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G  GF E RAVFYAAE+CCGL
Sbjct: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299

Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
           EDL RERIVYRDLKPENILLDD GHIRISDLGLA  +PEGQ ++GRVGTVGYMAPEVV N
Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359

Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
           E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K   EEYSE+FS  A+S+
Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419

Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
           C  LL K+P++RLGCRG  A  VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD
Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479

Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE 515
           IEQFS VKG+ L+  D+DFY +FATG V IPWQNE
Sbjct: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNE 514


>gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo
           sapiens]
          Length = 589

 Score =  756 bits (1951), Expect = 0.0
 Identities = 358/515 (69%), Positives = 420/515 (81%), Gaps = 1/515 (0%)

Query: 1   MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
           MELENIVAN++LLKAR+GG G + G+SKKW+++L  P +SQC ELR S+E+DY SLC++Q
Sbjct: 1   MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60

Query: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
           PIGR LFR+FC T+P L R + FLD VAEYEV  D+ R  CG  +   F +      +PE
Sbjct: 61  PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120

Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
           +P  +VT C   L E+ P K  F+E TR+ H YL   PF +Y +S YF++FLQWKWLERQ
Sbjct: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179

Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
           PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239

Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
           KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G  GF E RAVFYAAE+CCGL
Sbjct: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299

Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
           EDL RERIVYRDLKPENILLDD GHIRISDLGLA  +PEGQ ++GRVGTVGYMAPEVV N
Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359

Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
           E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K   EEYSE+FS  A+S+
Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419

Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
           C  LL K+P++RLGCRG  A  VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD
Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479

Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE 515
           IEQFS VKG+ L+  D+DFY +FATG V IPWQNE
Sbjct: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNE 514


>gi|4506529 rhodopsin kinase [Homo sapiens]
          Length = 563

 Score =  486 bits (1252), Expect = e-137
 Identities = 253/530 (47%), Positives = 347/530 (65%), Gaps = 7/530 (1%)

Query: 3   LENIVANSLLLKARQGGYGKKS--GRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
           LE +VANS  + AR    G  S   R KK+   L LPP+S+C  LR S+  ++ S+C +Q
Sbjct: 6   LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65

Query: 61  PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
           PIG++LF+QF  +       +E    + +Y+ AD++ +     +IL ++ + +       
Sbjct: 66  PIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSF 125

Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
           +   +V + + G  E       F+   +    +L   PF+EY  S YF +FLQWKWLE Q
Sbjct: 126 LDEGIVAKFKEGPVEIQDG--LFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQ 183

Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
           P+ ++ F  +RVLGKGGFGEV ACQ++ATGK+YACKKL KKR+KKRKG   A+ EK+IL 
Sbjct: 184 PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILM 243

Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG--NPGFDEQRAVFYAAELCC 298
           KV SRF+VSLAYA+ETK  LCLV+TIMNGGD+++HIYN+   NPGF E RA+FY A++ C
Sbjct: 244 KVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIIC 303

Query: 299 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEV 357
           GLE L + RIVYRDLKPEN+LLD+ G++RISDLGLA E+ +GQ + +G  GT G+MAPE+
Sbjct: 304 GLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPEL 363

Query: 358 VNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDA 417
           +  E+Y FS D++ LG  +YEMI    PF+   EKV+ +E+  RI ++  +Y +KFS+ +
Sbjct: 364 LQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQAS 423

Query: 418 KSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKD 477
           K  C  LL K+P KRLG R E    ++ HP+FKD+N+R+LEA ML PPF PD   VY KD
Sbjct: 424 KDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKD 483

Query: 478 VLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEGCLTMVPSEKEV 527
           + D+  FS VKG+  D  D +F+  FATG   IPWQ E   T +  E  V
Sbjct: 484 IQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNV 533


>gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]
          Length = 553

 Score =  481 bits (1237), Expect = e-136
 Identities = 248/517 (47%), Positives = 338/517 (65%), Gaps = 7/517 (1%)

Query: 3   LENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPI 62
           L+N++AN+  L+AR+      S   ++ +  L LP +  C+ELR  +  ++ SLC++QPI
Sbjct: 7   LDNLIANTAYLQARKPS-DCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPI 65

Query: 63  GRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAA--PLPE 120
           GRRLFR F  T PT ++   FL+ V  +E+A++    D  L  L        A   P P 
Sbjct: 66  GRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPF 125

Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
           +   V T+C+    EE     A       A  +L+ +PF+++  S+++ +FLQWK  E Q
Sbjct: 126 LSQAVATKCQAATTEEE-RVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQ 184

Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
           PV+   F  +RVLGKGGFGEVCA QV+ TGKMYACKKL KKR+KK+ GE MAL EK ILE
Sbjct: 185 PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILE 244

Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
           KV S F+VSLAYA+E+K  LCLV+++MNGGDLKFHIYN+G  G D  R +FY+A++ CG+
Sbjct: 245 KVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGM 304

Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
             L    IVYRD+KPEN+LLDD G+ R+SDLGLA E+  G+ +  R GT GYMAPE++  
Sbjct: 305 LHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILME 364

Query: 361 E-KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYS-EKFSEDAK 418
           +  Y++  DW+ +GC IYEM+ G +PFK YKEKV  E++ QR   D  ++  + F+E+AK
Sbjct: 365 KVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAK 424

Query: 419 SICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDV 478
            ICR+ L K P +RLG R E +   ++H  FK INF RLEA ++EPPF PDP  VY KD+
Sbjct: 425 DICRLFLAKKPEQRLGSR-EKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDI 483

Query: 479 LDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE 515
            +I+ FS V+G+  D  D+ F+  FATG V I WQ E
Sbjct: 484 AEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEE 520


>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
          Length = 688

 Score =  308 bits (790), Expect = 6e-84
 Identities = 192/526 (36%), Positives = 284/526 (53%), Gaps = 20/526 (3%)

Query: 2   ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59
           +LE ++A+   L A +      + R+ K    + LP  S  S ++  + +      DK  
Sbjct: 3   DLEAVLADVSYLMAMEKSKATPAARASKR---IVLPEPSIRSVMQKYLAERNEITFDKIF 59

Query: 60  -QPIGRRLFRQFCDTKPT-LKRHIEFLDAVAEYEVADDEDRSDC-GLSILDRFFNDKLAA 116
            Q IG  LF+ FC  +       ++F + + EYE  D+E+   C    I D +   +L +
Sbjct: 60  NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLS 119

Query: 117 PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKW 176
                    V   +  L ++  +   F+         LRG+ F+++ ES  F++F QWK 
Sbjct: 120 CSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKN 179

Query: 177 LERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNE 235
           +E    +T N F  +R++G+GGFGEV  C+   TGKMYA K L KKRIK ++GE +ALNE
Sbjct: 180 VELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239

Query: 236 KRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFY 292
           + +L  V +    F+V + YA+ T D LC +L +MNGGDL +H+   G   F E+   FY
Sbjct: 240 RIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--VFSEKEMRFY 297

Query: 293 AAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGY 352
           A E+  GLE +    +VYRDLKP NILLD+ GH RISDLGLA +  + ++    VGT GY
Sbjct: 298 ATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSK-KKPHASVGTHGY 356

Query: 353 MAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSE 411
           MAPEV+     Y  S DW+ LGC+++++++GHSPF+++K K K  E+D+       E  +
Sbjct: 357 MAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVELPD 415

Query: 412 KFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPH 471
            FS + KS+   LL ++ SKRLGC G G+  VK+H  FK ++++ +      PP  P   
Sbjct: 416 TFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRG 475

Query: 472 AVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNE 515
            V   D  DI  F     KGI L   D++ Y  F    +S  WQ E
Sbjct: 476 EVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQE 520


>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
          Length = 689

 Score =  298 bits (762), Expect = 1e-80
 Identities = 194/533 (36%), Positives = 292/533 (54%), Gaps = 34/533 (6%)

Query: 2   ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59
           +LE ++A+   L A +      + R+ K    + LP  S  S ++  +E       +K  
Sbjct: 3   DLEAVLADVSYLMAMEKSKATPAARASKK---ILLPEPSIRSVMQKYLEDRGEVTFEKIF 59

Query: 60  -QPIGRRLFRQFC-----DTKPTLKRHIEFLDAVAEYEVAD-DEDRSDCGLSILDRFFND 112
            Q +G  LFR FC     + +P     +EF + + +YE  + +E+R      I D +   
Sbjct: 60  SQKLGYLLFRDFCLNHLEEARPL----VEFYEEIKKYEKLETEEERVARSREIFDSYIMK 115

Query: 113 KLAA---PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFS 169
           +L A   P  +   + V +  LG K+  P    F+         LRG+ F+++ ES  F+
Sbjct: 116 ELLACSHPFSKSATEHV-QGHLGKKQVPPD--LFQPYIEEICQNLRGDVFQKFIESDKFT 172

Query: 170 QFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKG 228
           +F QWK +E    +T N F  +R++G+GGFGEV  C+   TGKMYA K L KKRIK ++G
Sbjct: 173 RFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG 232

Query: 229 EAMALNEKRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFD 285
           E +ALNE+ +L  V +    F+V ++YA+ T D L  +L +MNGGDL +H+   G   F 
Sbjct: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFS 290

Query: 286 EQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRG 345
           E    FYAAE+  GLE +    +VYRDLKP NILLD+ GH+RISDLGLA +  + ++   
Sbjct: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHA 349

Query: 346 RVGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKN 404
            VGT GYMAPEV+     Y  S DW+ LGC+++++++GHSPF+++K K K  E+D+    
Sbjct: 350 SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLT 408

Query: 405 DTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEP 464
              E  + FS + +S+   LL ++ ++RLGC G GA  VK+ P F+ ++++ +      P
Sbjct: 409 MAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPP 468

Query: 465 PFCPDPHAVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNE 515
           P  P    V   D  DI  F     KGI L  +D++ Y  F    +S  WQ E
Sbjct: 469 PLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQE 520


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  209 bits (533), Expect = 4e-54
 Identities = 118/286 (41%), Positives = 167/286 (58%), Gaps = 12/286 (4%)

Query: 185 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE-KVQ 243
           N F  ++VLGKG FG+V   +++  G+ +A K L+K  +         + EKR+L    +
Sbjct: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406

Query: 244 SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 303
           + F+  L   ++TKD L  V+  +NGGDL +HI + G   F+  RA FYAAE+ CGL+ L
Sbjct: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFL 464

Query: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEK 362
             + I+YRDLK +N+LLD  GHI+I+D G+  E   G+ R     GT  Y+APE++   K
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524

Query: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 422
           YTFS DWW  G L+YEM+ G SPF    E    +E+ + I+ DT  Y    ++++K I  
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580

Query: 423 MLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
            L  + P+KRLG  G     +K HP FK IN+  LE   LEPPF P
Sbjct: 581 KLFEREPTKRLGVTG----NIKIHPFFKTINWTLLEKRRLEPPFRP 622


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  209 bits (533), Expect = 4e-54
 Identities = 118/286 (41%), Positives = 167/286 (58%), Gaps = 12/286 (4%)

Query: 185 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE-KVQ 243
           N F  ++VLGKG FG+V   +++  G+ +A K L+K  +         + EKR+L    +
Sbjct: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406

Query: 244 SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 303
           + F+  L   ++TKD L  V+  +NGGDL +HI + G   F+  RA FYAAE+ CGL+ L
Sbjct: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFL 464

Query: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEK 362
             + I+YRDLK +N+LLD  GHI+I+D G+  E   G+ R     GT  Y+APE++   K
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524

Query: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 422
           YTFS DWW  G L+YEM+ G SPF    E    +E+ + I+ DT  Y    ++++K I  
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580

Query: 423 MLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
            L  + P+KRLG  G     +K HP FK IN+  LE   LEPPF P
Sbjct: 581 KLFEREPTKRLGVTG----NIKIHPFFKTINWTLLEKRRLEPPFRP 622


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  206 bits (523), Expect = 6e-53
 Identities = 113/284 (39%), Positives = 165/284 (58%), Gaps = 8/284 (2%)

Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR- 245
           F    VLGKG FG+V     + T ++YA K L+K  + +       + EKR+L  +    
Sbjct: 339 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP 398

Query: 246 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 305
           F+  L   ++T D L  V+  +NGGDL +HI  +G   F E +AVFYAAE+  GL  L +
Sbjct: 399 FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAEISIGLFFLHK 456

Query: 306 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 364
             I+YRDLK +N++LD  GHI+I+D G+  E + +G   R   GT  Y+APE++  + Y 
Sbjct: 457 RGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYG 516

Query: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424
            S DWW  G L+YEM+ G  PF    E    +E+ Q I      Y +  S++A SIC+ L
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKSLSKEAVSICKGL 572

Query: 425 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
           +TK+P+KRLGC  EG   V++H  F+ I++ +LE   ++PPF P
Sbjct: 573 MTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP 616


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  206 bits (523), Expect = 6e-53
 Identities = 112/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%)

Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-QSR 245
           F    VLGKG FG+V   + + T ++YA K L+K  + +       + EKR+L    +  
Sbjct: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401

Query: 246 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 305
           F+  L   ++T D L  V+  +NGGDL +HI  +G   F E  AVFYAAE+  GL  LQ 
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459

Query: 306 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 364
           + I+YRDLK +N++LD  GHI+I+D G+  E I +G   +   GT  Y+APE++  + Y 
Sbjct: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519

Query: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424
            S DWW  G L+YEM+ G +PF+   E    +E+ Q I      Y +  S++A +IC+ L
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575

Query: 425 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
           +TK+P KRLGC  EG   +K+H  F+ I++ +LE   ++PP+ P
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  206 bits (523), Expect = 6e-53
 Identities = 112/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%)

Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-QSR 245
           F    VLGKG FG+V   + + T ++YA K L+K  + +       + EKR+L    +  
Sbjct: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401

Query: 246 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 305
           F+  L   ++T D L  V+  +NGGDL +HI  +G   F E  AVFYAAE+  GL  LQ 
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459

Query: 306 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 364
           + I+YRDLK +N++LD  GHI+I+D G+  E I +G   +   GT  Y+APE++  + Y 
Sbjct: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519

Query: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424
            S DWW  G L+YEM+ G +PF+   E    +E+ Q I      Y +  S++A +IC+ L
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575

Query: 425 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
           +TK+P KRLGC  EG   +K+H  F+ I++ +LE   ++PP+ P
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  205 bits (521), Expect = 1e-52
 Identities = 120/296 (40%), Positives = 167/296 (56%), Gaps = 11/296 (3%)

Query: 177 LERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEK 236
           L + P+T   F+   VLG+G FG+V   + R +G+++A K L+K  I  R      + EK
Sbjct: 611 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 670

Query: 237 RILEKVQSR---FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYA 293
           RIL  V S    F+V+L   ++T + +C V+    GGDL  HI++     F E RA+FY+
Sbjct: 671 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 727

Query: 294 AELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGY 352
           A +  GL+ L   +IVYRDLK +N+LLD  G+++I+D GL  E +  G R     GT  +
Sbjct: 728 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 787

Query: 353 MAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 412
           +APEV+ +  YT + DWWGLG L+YEM+ G SPF    E    EEV   I ND   Y   
Sbjct: 788 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 843

Query: 413 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
            S +A  I R LL +NP +RLG     A  VK+ P F+ + +  L A  L PPF P
Sbjct: 844 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 899


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  205 bits (521), Expect = 1e-52
 Identities = 120/296 (40%), Positives = 167/296 (56%), Gaps = 11/296 (3%)

Query: 177 LERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEK 236
           L + P+T   F+   VLG+G FG+V   + R +G+++A K L+K  I  R      + EK
Sbjct: 605 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 664

Query: 237 RILEKVQSR---FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYA 293
           RIL  V S    F+V+L   ++T + +C V+    GGDL  HI++     F E RA+FY+
Sbjct: 665 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 721

Query: 294 AELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGY 352
           A +  GL+ L   +IVYRDLK +N+LLD  G+++I+D GL  E +  G R     GT  +
Sbjct: 722 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 781

Query: 353 MAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 412
           +APEV+ +  YT + DWWGLG L+YEM+ G SPF    E    EEV   I ND   Y   
Sbjct: 782 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 837

Query: 413 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
            S +A  I R LL +NP +RLG     A  VK+ P F+ + +  L A  L PPF P
Sbjct: 838 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 893


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  204 bits (519), Expect = 2e-52
 Identities = 123/286 (43%), Positives = 163/286 (56%), Gaps = 11/286 (3%)

Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQS-- 244
           FR   VLG+G FG+V   + + T +M+A K L+K  I  R      + EKRI E V S  
Sbjct: 657 FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR 716

Query: 245 -RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 303
             F+V+L   ++TK+ +C V+    GGDL  HI+      F E RAVFYAA +  GL+ L
Sbjct: 717 HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT---DVFSEPRAVFYAACVVLGLQYL 773

Query: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEK 362
              +IVYRDLK +N+LLD  G ++I+D GL  E +  G R     GT  ++APEV+    
Sbjct: 774 HEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS 833

Query: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 422
           YT + DWWGLG LIYEM+ G SPF    E    EEV   I ND   Y    S +A SI R
Sbjct: 834 YTRAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRFLSTEAISIMR 889

Query: 423 MLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
            LL +NP +RLG   + A  VK+HP F+ I++  L    ++PPF P
Sbjct: 890 RLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIP 935


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  201 bits (511), Expect = 1e-51
 Identities = 113/287 (39%), Positives = 167/287 (58%), Gaps = 7/287 (2%)

Query: 183 TKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV 242
           T N F + ++LGKG FG+V   + +A+GK YA K L+K+ I  +   A  L E R+L+  
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203

Query: 243 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLED 302
           +  F+ SL Y+++TKD LC V+  +NGG+L FH+       F E R  FY AE+   L+ 
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR--ERVFSEDRTRFYGAEIVSALDY 261

Query: 303 LQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNE 361
           L   +IVYRDLK EN++LD  GHI+I+D GL  E I +   ++   GT  Y+APEV+ + 
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321

Query: 362 KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSIC 421
            Y  + DWWGLG ++YEM+ G  PF         E++ + I  +  ++    S DAKS+ 
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEDIKFPRTLSSDAKSLL 377

Query: 422 RMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
             LL K+P+KRLG   + A  + +H  F  +N++ +    L PPF P
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  201 bits (511), Expect = 1e-51
 Identities = 113/287 (39%), Positives = 167/287 (58%), Gaps = 7/287 (2%)

Query: 183 TKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV 242
           T N F + ++LGKG FG+V   + +A+GK YA K L+K+ I  +   A  L E R+L+  
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203

Query: 243 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLED 302
           +  F+ SL Y+++TKD LC V+  +NGG+L FH+       F E R  FY AE+   L+ 
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR--ERVFSEDRTRFYGAEIVSALDY 261

Query: 303 LQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNE 361
           L   +IVYRDLK EN++LD  GHI+I+D GL  E I +   ++   GT  Y+APEV+ + 
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321

Query: 362 KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSIC 421
            Y  + DWWGLG ++YEM+ G  PF         E++ + I  +  ++    S DAKS+ 
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEDIKFPRTLSSDAKSLL 377

Query: 422 RMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
             LL K+P+KRLG   + A  + +H  F  +N++ +    L PPF P
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  201 bits (510), Expect = 2e-51
 Identities = 114/287 (39%), Positives = 163/287 (56%), Gaps = 9/287 (3%)

Query: 185 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQS 244
           + F   RVLGKG FG+V   +V+ TG +YA K L+K  I +       + EKRIL   ++
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412

Query: 245 R-FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 303
             F+  L   ++T D L  V+  +NGGDL FHI    +  FDE RA FYAAE+   L  L
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK--SRRFDEARARFYAAEIISALMFL 470

Query: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEK 362
             + I+YRDLK +N+LLD  GH +++D G+  E I  G       GT  Y+APE++    
Sbjct: 471 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 530

Query: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 422
           Y  + DWW +G L+YEM+ GH+PF+   E    +++ + I ND   Y     EDA  I +
Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENE----DDLFEAILNDEVVYPTWLHEDATGILK 586

Query: 423 MLLTKNPSKRLGCRGEGAA-GVKQHPVFKDINFRRLEANMLEPPFCP 468
             +TKNP+ RLG   +G    + +HP FK+I++ +L    +EPPF P
Sbjct: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 633


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  199 bits (505), Expect = 7e-51
 Identities = 114/291 (39%), Positives = 165/291 (56%), Gaps = 7/291 (2%)

Query: 179 RQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRI 238
           R  VT N F + ++LGKG FG+V   + +ATG+ YA K L+K+ I  +   A  + E R+
Sbjct: 144 RAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRV 203

Query: 239 LEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCC 298
           L+  +  F+ +L YA++T D LC V+   NGG+L FH+       F E+RA FY AE+  
Sbjct: 204 LQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVS 261

Query: 299 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEV 357
            LE L    +VYRD+K EN++LD  GHI+I+D GL  E I +G  ++   GT  Y+APEV
Sbjct: 262 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 321

Query: 358 VNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDA 417
           + +  Y  + DWWGLG ++YEM+ G  PF         E + + I  +   +    S +A
Sbjct: 322 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----ERLFELILMEEIRFPRTLSPEA 377

Query: 418 KSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
           KS+   LL K+P +RLG     A  V +H  F  IN++ +    L PPF P
Sbjct: 378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 428


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  197 bits (500), Expect = 3e-50
 Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 8/289 (2%)

Query: 182 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 241
           VT N F + ++LGKG FG+V   + +ATG+ YA K L+K+ I  +   A  L E R+L+ 
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204

Query: 242 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301
            +  F+ +L Y+++T D LC V+   NGG+L FH+       F E RA FY AE+   L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262

Query: 302 DLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 359
            L  E+ +VYRDLK EN++LD  GHI+I+D GL  E I +G  ++   GT  Y+APEV+ 
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322

Query: 360 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419
           +  Y  + DWWGLG ++YEM+ G  PF         E++ + I  +   +      +AKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKS 378

Query: 420 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
           +   LL K+P +RLG   E A  + QH  F  I ++ +    L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  197 bits (500), Expect = 3e-50
 Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 8/289 (2%)

Query: 182 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 241
           VT N F + ++LGKG FG+V   + +ATG+ YA K L+K+ I  +   A  L E R+L+ 
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204

Query: 242 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301
            +  F+ +L Y+++T D LC V+   NGG+L FH+       F E RA FY AE+   L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262

Query: 302 DLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 359
            L  E+ +VYRDLK EN++LD  GHI+I+D GL  E I +G  ++   GT  Y+APEV+ 
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322

Query: 360 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419
           +  Y  + DWWGLG ++YEM+ G  PF         E++ + I  +   +      +AKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKS 378

Query: 420 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
           +   LL K+P +RLG   E A  + QH  F  I ++ +    L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  197 bits (500), Expect = 3e-50
 Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 8/289 (2%)

Query: 182 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 241
           VT N F + ++LGKG FG+V   + +ATG+ YA K L+K+ I  +   A  L E R+L+ 
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204

Query: 242 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301
            +  F+ +L Y+++T D LC V+   NGG+L FH+       F E RA FY AE+   L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262

Query: 302 DLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 359
            L  E+ +VYRDLK EN++LD  GHI+I+D GL  E I +G  ++   GT  Y+APEV+ 
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322

Query: 360 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419
           +  Y  + DWWGLG ++YEM+ G  PF         E++ + I  +   +      +AKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKS 378

Query: 420 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
           +   LL K+P +RLG   E A  + QH  F  I ++ +    L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  196 bits (497), Expect = 6e-50
 Identities = 109/281 (38%), Positives = 160/281 (56%), Gaps = 12/281 (4%)

Query: 190 YRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-QSRFVV 248
           +++LGKG FG+V   + + T + +A K L+K  +         + EKR+L    +  F+ 
Sbjct: 383 HKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLT 442

Query: 249 SLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERI 308
            +   ++TK+ L  V+  +NGGDL +HI +     FD  RA FYAAE+  GL+ L  + I
Sbjct: 443 HMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK--FDLSRATFYAAEIILGLQFLHSKGI 500

Query: 309 VYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEKYTFSP 367
           VYRDLK +NILLD  GHI+I+D G+  E   G  +     GT  Y+APE++  +KY  S 
Sbjct: 501 VYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSV 560

Query: 368 DWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTK 427
           DWW  G L+YEM+ G SPF    E    EE+   I+ D   Y     ++AK +   L  +
Sbjct: 561 DWWSFGVLLYEMLIGQSPFHGQDE----EELFHSIRMDNPFYPRWLEKEAKDLLVKLFVR 616

Query: 428 NPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
            P KRLG RG+    ++QHP+F++IN+  LE   ++PPF P
Sbjct: 617 EPEKRLGVRGD----IRQHPLFREINWEELERKEIDPPFRP 653


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score =  194 bits (494), Expect = 1e-49
 Identities = 114/291 (39%), Positives = 158/291 (54%), Gaps = 13/291 (4%)

Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV---- 242
           F    VLGKG FG+V   + R + ++YA K L+K  I +       L EKR+L       
Sbjct: 351 FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGP 410

Query: 243 --QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
             +  F+  L   ++T D L  V+  + GGDL +HI  LG   F E  A FYAAE+  GL
Sbjct: 411 GGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGK--FKEPHAAFYAAEIAIGL 468

Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 359
             L  + I+YRDLK +N++LD  GHI+I+D G+  E +  G   R   GT  Y+APE++ 
Sbjct: 469 FFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIA 528

Query: 360 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419
            + Y  S DWW  G L+YEM+ G  PF    E    EE+ Q I   T  Y +  S +A +
Sbjct: 529 YQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDE----EELFQAIMEQTVTYPKSLSREAVA 584

Query: 420 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDP 470
           IC+  LTK+P KRLG   +G   ++ H  F+ I++ RLE   + PPF P P
Sbjct: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRP 635


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  192 bits (487), Expect = 8e-49
 Identities = 112/286 (39%), Positives = 162/286 (56%), Gaps = 10/286 (3%)

Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR- 245
           F   +VLGKG FG+V   +++   ++YA K L+K  I +       + EKRIL   +   
Sbjct: 408 FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP 467

Query: 246 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 305
           ++  L   ++TKD L  V+  +NGGDL F I    +  FDE R+ FYAAE+   L  L +
Sbjct: 468 YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQR--SRKFDEPRSRFYAAEVTSALMFLHQ 525

Query: 306 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 364
             ++YRDLK +NILLD  GH +++D G+  E I  G       GT  Y+APE++   +Y 
Sbjct: 526 HGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYG 585

Query: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424
            S DWW LG L+YEM+ G  PF+   E    +++ + I +D   Y    S++A SI +  
Sbjct: 586 PSVDWWALGVLMYEMMAGQPPFEADNE----DDLFESILHDDVLYPVWLSKEAVSILKAF 641

Query: 425 LTKNPSKRLGC--RGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
           +TKNP KRLGC     G   +KQHP FK+I++  LE   ++PPF P
Sbjct: 642 MTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKP 687


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
           sapiens]
          Length = 482

 Score =  186 bits (473), Expect = 4e-47
 Identities = 115/287 (40%), Positives = 166/287 (57%), Gaps = 11/287 (3%)

Query: 187 FRHYRVLGKGGFGEVCACQ-VRAT--GKMYACKKLQKKRI-KKRKGEAMALNEKRILEKV 242
           F   RVLGKGG+G+V   + V+ T  GK+YA K L+K +I +  K  A    E+ ILE V
Sbjct: 67  FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126

Query: 243 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLED 302
           +  F+V LAYA++T   L L+L  ++GG+L  H+   G   F E  A FY AE+   L  
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGI--FLEDTACFYLAEITLALGH 184

Query: 303 LQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNE 361
           L  + I+YRDLKPENI+L  +GHI+++D GL  E I EG       GT+ YMAPE++   
Sbjct: 185 LHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRS 244

Query: 362 KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSIC 421
            +  + DWW LG L+Y+M+ G  PF     K   +++  R K     Y    + DA+ + 
Sbjct: 245 GHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKI-IRGKLALPPY---LTPDARDLV 300

Query: 422 RMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
           +  L +NPS+R+G     AA V++HP F+ +N+  L A  ++PPF P
Sbjct: 301 KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRP 347


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,966,116
Number of Sequences: 37866
Number of extensions: 1035358
Number of successful extensions: 4388
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 666
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 2202
Number of HSP's gapped (non-prelim): 932
length of query: 532
length of database: 18,247,518
effective HSP length: 107
effective length of query: 425
effective length of database: 14,195,856
effective search space: 6033238800
effective search space used: 6033238800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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