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Search of human proteins with 51873045
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51873045 G protein-coupled receptor kinase 4 isoform beta
[Homo sapiens]
(546 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho... 1130 0.0
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H... 1113 0.0
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 997 0.0
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens] 734 0.0
gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo ... 730 0.0
gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo ... 728 0.0
gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo ... 728 0.0
gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens] 472 e-133
gi|4506529 rhodopsin kinase [Homo sapiens] 470 e-132
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 307 2e-83
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens] 297 1e-80
gi|47157325 protein kinase C, delta [Homo sapiens] 209 4e-54
gi|31377782 protein kinase C, delta [Homo sapiens] 209 4e-54
gi|4506067 protein kinase C, alpha [Homo sapiens] 206 6e-53
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 206 6e-53
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 206 6e-53
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 205 1e-52
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 205 1e-52
gi|5453974 protein kinase N2 [Homo sapiens] 204 2e-52
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 201 1e-51
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 201 1e-51
gi|28557781 protein kinase C, eta [Homo sapiens] 201 2e-51
gi|4502023 AKT2 kinase [Homo sapiens] 199 7e-51
gi|62241015 AKT1 kinase [Homo sapiens] 197 3e-50
gi|62241013 AKT1 kinase [Homo sapiens] 197 3e-50
gi|62241011 AKT1 kinase [Homo sapiens] 197 3e-50
gi|5453976 protein kinase C, theta [Homo sapiens] 196 6e-50
gi|13384594 protein kinase C, gamma [Homo sapiens] 194 1e-49
gi|4885563 protein kinase C, epsilon [Homo sapiens] 192 9e-49
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 186 4e-47
>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
sapiens]
Length = 546
Score = 1130 bits (2922), Expect = 0.0
Identities = 546/546 (100%), Positives = 546/546 (100%)
Query: 1 MELENIVANSLLLKARQEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEV 60
MELENIVANSLLLKARQEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEV
Sbjct: 1 MELENIVANSLLLKARQEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEV 60
Query: 61 ADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHN 120
ADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHN
Sbjct: 61 ADDEDRSDCGLSILDRFFNDKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHN 120
Query: 121 YLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKM 180
YLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKM
Sbjct: 121 YLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKM 180
Query: 181 YACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDL 240
YACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDL
Sbjct: 181 YACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDL 240
Query: 241 KFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLG 300
KFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLG
Sbjct: 241 KFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLG 300
Query: 301 LATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEK 360
LATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEK
Sbjct: 301 LATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEK 360
Query: 361 VKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDI 420
VKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDI
Sbjct: 361 VKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDI 420
Query: 421 NFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPW 480
NFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPW
Sbjct: 421 NFRRLEANMLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPW 480
Query: 481 QNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKE 540
QNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKE
Sbjct: 481 QNEMIESGCFKDINKSESEEALPLDLDKNIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKE 540
Query: 541 VEPKQC 546
VEPKQC
Sbjct: 541 VEPKQC 546
>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
sapiens]
Length = 578
Score = 1113 bits (2879), Expect = 0.0
Identities = 546/578 (94%), Positives = 546/578 (94%), Gaps = 32/578 (5%)
Query: 1 MELENIVANSLLLKARQ--------------------------------EKDYSSLCDKQ 28
MELENIVANSLLLKARQ EKDYSSLCDKQ
Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
Query: 29 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 88
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
Query: 89 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 148
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 149 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 208
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 209 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
Query: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 328
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
Query: 329 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 388
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
Query: 389 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 448
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
Query: 449 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 508
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
Query: 509 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 546
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
Sbjct: 541 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 578
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 997 bits (2577), Expect = 0.0
Identities = 500/578 (86%), Positives = 500/578 (86%), Gaps = 78/578 (13%)
Query: 1 MELENIVANSLLLKARQ--------------------------------EKDYSSLCDKQ 28
MELENIVANSLLLKARQ EKDYSSLCDKQ
Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
Query: 29 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 88
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
Query: 89 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 148
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 149 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 208
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 209 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
Query: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 328
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
Query: 329 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 388
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
Query: 389 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 448
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
Query: 449 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 508
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE
Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE------------------------- 515
Query: 509 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 546
GCLTMVPSEKEVEPKQC
Sbjct: 516 ---------------------GCLTMVPSEKEVEPKQC 532
>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
Length = 590
Score = 734 bits (1896), Expect = 0.0
Identities = 361/560 (64%), Positives = 433/560 (77%), Gaps = 35/560 (6%)
Query: 1 MELENIVANSLLLKARQ--------------------------------EKDYSSLCDKQ 28
MELENIVAN++LLKAR+ ++DY SLCDKQ
Sbjct: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
Query: 29 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 88
PIGR LFRQFC+T+P L+ +I+FLD+VAEYEV DE + G I+ ++ K + +
Sbjct: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
Query: 89 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 148
+ D+V++ L ++ P K+ F C + H YLRGEPF EY +S +F +FLQWKWLERQ
Sbjct: 121 VGQDLVSQTEEKLLQK-PCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179
Query: 149 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 208
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACK+L+KKRIKKRKGE+MALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239
Query: 209 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268
KV S+FVV+LAYAYETKDALCLVLTIMNGGDLKFHIYN+GNPGF+E+RA+FYAAE+ CGL
Sbjct: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299
Query: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 328
EDL RE VYRDLKPENILLDD GHIRISDLGLA +IPEG +RGRVGTVGYMAPEV+NN
Sbjct: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359
Query: 329 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 388
++Y SPD+WGLGCLIYEMI+G SPF+ KEKVK EEVD+R+ E YS KFSE+AKSI
Sbjct: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419
Query: 389 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 448
C+MLLTK+ +RLGC+ EGAA VK+HP F+++NF+RLEA ML+PPF PDP AVYCKDVLD
Sbjct: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479
Query: 449 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 508
IEQFS VKG+ LD D+DFY++F+TG VSIPWQNEMIE+ CFK++N LP DL++
Sbjct: 480 IEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNR 539
Query: 509 NIHTPVSRPNRGFFYRLFRR 528
N P P +G RLF+R
Sbjct: 540 N--HPPEPPKKGLLQRLFKR 557
>gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo
sapiens]
Length = 576
Score = 730 bits (1885), Expect = 0.0
Identities = 360/575 (62%), Positives = 426/575 (74%), Gaps = 34/575 (5%)
Query: 1 MELENIVANSLLLKARQ--------------------------------EKDYSSLCDKQ 28
MELENIVAN++LLKAR+ E+DY SLC++Q
Sbjct: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 29 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 88
PIGR LFR+FC T+P L R + FLD VAEYEV D+ R CG + F + +PE
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 89 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 148
+P +VT C L E+ P K F+E TR+ H YL PF +Y +S YF++FLQWKWLERQ
Sbjct: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179
Query: 149 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 208
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239
Query: 209 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268
KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G GF E RAVFYAAE+CCGL
Sbjct: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299
Query: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 328
EDL RERIVYRDLKPENILLDD GHIRISDLGLA +PEGQ ++GRVGTVGYMAPEVV N
Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359
Query: 329 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 388
E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K EEYSE+FS A+S+
Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419
Query: 389 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 448
C LL K+P++RLGCRG A VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD
Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479
Query: 449 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 508
IEQFS VKG+ L+ D+DFY +FATG V IPWQNEM+E+ CF+++N + ++P DLD
Sbjct: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDW 539
Query: 509 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEP 543
P + P +G RLF R C +E P
Sbjct: 540 K-GQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELP 573
>gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo
sapiens]
Length = 560
Score = 728 bits (1878), Expect = 0.0
Identities = 357/560 (63%), Positives = 422/560 (75%), Gaps = 34/560 (6%)
Query: 1 MELENIVANSLLLKARQ--------------------------------EKDYSSLCDKQ 28
MELENIVAN++LLKAR+ E+DY SLC++Q
Sbjct: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 29 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 88
PIGR LFR+FC T+P L R + FLD VAEYEV D+ R CG + F + +PE
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 89 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 148
+P +VT C L E+ P K F+E TR+ H YL PF +Y +S YF++FLQWKWLERQ
Sbjct: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179
Query: 149 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 208
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239
Query: 209 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268
KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G GF E RAVFYAAE+CCGL
Sbjct: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299
Query: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 328
EDL RERIVYRDLKPENILLDD GHIRISDLGLA +PEGQ ++GRVGTVGYMAPEVV N
Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359
Query: 329 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 388
E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K EEYSE+FS A+S+
Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419
Query: 389 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 448
C LL K+P++RLGCRG A VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD
Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479
Query: 449 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 508
IEQFS VKG+ L+ D+DFY +FATG V IPWQNEM+E+ CF+++N + ++P DLD
Sbjct: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDW 539
Query: 509 NIHTPVSRPNRGFFYRLFRR 528
P + P +G RLF R
Sbjct: 540 K-GQPPAPPKKGLLQRLFSR 558
>gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo
sapiens]
Length = 589
Score = 728 bits (1878), Expect = 0.0
Identities = 357/560 (63%), Positives = 422/560 (75%), Gaps = 34/560 (6%)
Query: 1 MELENIVANSLLLKARQ--------------------------------EKDYSSLCDKQ 28
MELENIVAN++LLKAR+ E+DY SLC++Q
Sbjct: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 29 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 88
PIGR LFR+FC T+P L R + FLD VAEYEV D+ R CG + F + +PE
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 89 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 148
+P +VT C L E+ P K F+E TR+ H YL PF +Y +S YF++FLQWKWLERQ
Sbjct: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179
Query: 149 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 208
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239
Query: 209 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268
KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G GF E RAVFYAAE+CCGL
Sbjct: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299
Query: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 328
EDL RERIVYRDLKPENILLDD GHIRISDLGLA +PEGQ ++GRVGTVGYMAPEVV N
Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359
Query: 329 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 388
E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K EEYSE+FS A+S+
Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419
Query: 389 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 448
C LL K+P++RLGCRG A VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD
Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479
Query: 449 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 508
IEQFS VKG+ L+ D+DFY +FATG V IPWQNEM+E+ CF+++N + ++P DLD
Sbjct: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDW 539
Query: 509 NIHTPVSRPNRGFFYRLFRR 528
P + P +G RLF R
Sbjct: 540 K-GQPPAPPKKGLLQRLFSR 558
>gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]
Length = 553
Score = 472 bits (1215), Expect = e-133
Identities = 239/486 (49%), Positives = 324/486 (66%), Gaps = 6/486 (1%)
Query: 13 LKARQEKDYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLS 72
L+ + ++ SLC++QPIGRRLFR F T PT ++ FL+ V +E+A++ D L
Sbjct: 48 LRQKLSLNFHSLCEQQPIGRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQ 107
Query: 73 ILDRFFNDKLAA--PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEY 130
L A P P + V T+C+ EE A A +L+ +PF+++
Sbjct: 108 GLVATCASAPAPGNPQPFLSQAVATKCQAATTEEE-RVAAVTLAKAEAMAFLQEQPFKDF 166
Query: 131 QESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKR 190
S+++ +FLQWK E QPV+ F +RVLGKGGFGEVCA QV+ TGKMYACKKL KKR
Sbjct: 167 VTSAFYDKFLQWKLFEMQPVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKR 226
Query: 191 IKKRKGEAMALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNP 250
+KK+ GE MAL EK ILEKV S F+VSLAYA+E+K LCLV+++MNGGDLKFHIYN+G
Sbjct: 227 LKKKGGEKMALLEKEILEKVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTR 286
Query: 251 GFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQR 310
G D R +FY+A++ CG+ L IVYRD+KPEN+LLDD G+ R+SDLGLA E+ G+
Sbjct: 287 GLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKP 346
Query: 311 VRGRVGTVGYMAPEVVNNE-KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQR 369
+ R GT GYMAPE++ + Y++ DW+ +GC IYEM+ G +PFK YKEKV E++ QR
Sbjct: 347 ITQRAGTNGYMAPEILMEKVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQR 406
Query: 370 IKNDTEEYS-EKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEAN 428
D ++ + F+E+AK ICR+ L K P +RLG R E + ++H FK INF RLEA
Sbjct: 407 TLQDEVKFQHDNFTEEAKDICRLFLAKKPEQRLGSR-EKSDDPRKHHFFKTINFPRLEAG 465
Query: 429 MLEPPFCPDPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESG 488
++EPPF PDP VY KD+ +I+ FS V+G+ D D+ F+ FATG V I WQ E+IE+G
Sbjct: 466 LIEPPFVPDPSVVYAKDIAEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETG 525
Query: 489 CFKDIN 494
F+++N
Sbjct: 526 LFEELN 531
>gi|4506529 rhodopsin kinase [Homo sapiens]
Length = 563
Score = 470 bits (1209), Expect = e-132
Identities = 237/490 (48%), Positives = 330/490 (67%), Gaps = 5/490 (1%)
Query: 20 DYSSLCDKQPIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFN 79
++ S+C +QPIG++LF+QF + +E + +Y+ AD++ + +IL ++ +
Sbjct: 57 EFESVCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLD 116
Query: 80 DKLAAPLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQF 139
+ + +V + + G E F+ + +L PF+EY S YF +F
Sbjct: 117 PQAKLFCSFLDEGIVAKFKEGPVEIQDG--LFQPLLQATLAHLGQAPFQEYLGSLYFLRF 174
Query: 140 LQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAM 199
LQWKWLE QP+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACKKL KKR+KKRKG
Sbjct: 175 LQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQG 234
Query: 200 ALNEKRILEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG--NPGFDEQRA 257
A+ EK+IL KV SRF+VSLAYA+ETK LCLV+TIMNGGD+++HIYN+ NPGF E RA
Sbjct: 235 AMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRA 294
Query: 258 VFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVG 316
+FY A++ CGLE L + RIVYRDLKPEN+LLD+ G++RISDLGLA E+ +GQ + +G G
Sbjct: 295 LFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAG 354
Query: 317 TVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEE 376
T G+MAPE++ E+Y FS D++ LG +YEMI PF+ EKV+ +E+ RI ++ +
Sbjct: 355 TPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVK 414
Query: 377 YSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
Y +KFS+ +K C LL K+P KRLG R E ++ HP+FKD+N+R+LEA ML PPF P
Sbjct: 415 YPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIP 474
Query: 437 DPHAVYCKDVLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKS 496
D VY KD+ D+ FS VKG+ D D +F+ FATG IPWQ EMIE+G F ++N
Sbjct: 475 DSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVW 534
Query: 497 ESEEALPLDL 506
S+ +P D+
Sbjct: 535 RSDGQMPDDM 544
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 307 bits (786), Expect = 2e-83
Identities = 180/469 (38%), Positives = 262/469 (55%), Gaps = 14/469 (2%)
Query: 28 QPIGRRLFRQFCDTKPT-LKRHIEFLDAVAEYEVADDEDRSDC-GLSILDRFFNDKLAAP 85
Q IG LF+ FC + ++F + + EYE D+E+ C I D + +L +
Sbjct: 61 QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC 120
Query: 86 LPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWL 145
V + L ++ + F+ LRG+ F+++ ES F++F QWK +
Sbjct: 121 SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV 180
Query: 146 ERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEK 204
E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++GE +ALNE+
Sbjct: 181 ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER 240
Query: 205 RILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYA 261
+L V + F+V + YA+ T D LC +L +MNGGDL +H+ G F E+ FYA
Sbjct: 241 IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--VFSEKEMRFYA 298
Query: 262 AELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYM 321
E+ GLE + +VYRDLKP NILLD+ GH RISDLGLA + + ++ VGT GYM
Sbjct: 299 TEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSK-KKPHASVGTHGYM 357
Query: 322 APEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 380
APEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+ E +
Sbjct: 358 APEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVELPDT 416
Query: 381 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHA 440
FS + KS+ LL ++ SKRLGC G G+ VK+H FK ++++ + PP P
Sbjct: 417 FSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGE 476
Query: 441 VYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIES 487
V D DI F KGI L D++ Y F +S WQ E+ E+
Sbjct: 477 VNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
Length = 689
Score = 297 bits (761), Expect = 1e-80
Identities = 185/483 (38%), Positives = 273/483 (56%), Gaps = 29/483 (6%)
Query: 28 QPIGRRLFRQFC-----DTKPTLKRHIEFLDAVAEYEVAD-DEDRSDCGLSILDRFFNDK 81
Q +G LFR FC + +P +EF + + +YE + +E+R I D + +
Sbjct: 61 QKLGYLLFRDFCLNHLEEARPL----VEFYEEIKKYEKLETEEERVARSREIFDSYIMKE 116
Query: 82 LAA---PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQ 138
L A P + + V + LG K+ P F+ LRG+ F+++ ES F++
Sbjct: 117 LLACSHPFSKSATEHV-QGHLGKKQVPPD--LFQPYIEEICQNLRGDVFQKFIESDKFTR 173
Query: 139 FLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGE 197
F QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++GE
Sbjct: 174 FCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGE 233
Query: 198 AMALNEKRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDE 254
+ALNE+ +L V + F+V ++YA+ T D L +L +MNGGDL +H+ G F E
Sbjct: 234 TLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSE 291
Query: 255 QRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGR 314
FYAAE+ GLE + +VYRDLKP NILLD+ GH+RISDLGLA + + ++
Sbjct: 292 ADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHAS 350
Query: 315 VGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKND 373
VGT GYMAPEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+
Sbjct: 351 VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTM 409
Query: 374 TEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPP 433
E + FS + +S+ LL ++ ++RLGC G GA VK+ P F+ ++++ + PP
Sbjct: 410 AVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPP 469
Query: 434 FCPDPHAVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFK 491
P V D DI F KGI L +D++ Y F +S WQ E+ E+ F
Sbjct: 470 LIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VFD 527
Query: 492 DIN 494
IN
Sbjct: 528 TIN 530
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 209 bits (533), Expect = 4e-54
Identities = 118/286 (41%), Positives = 167/286 (58%), Gaps = 12/286 (4%)
Query: 153 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE-KVQ 211
N F ++VLGKG FG+V +++ G+ +A K L+K + + EKR+L +
Sbjct: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
Query: 212 SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 271
+ F+ L ++TKD L V+ +NGGDL +HI + G F+ RA FYAAE+ CGL+ L
Sbjct: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFL 464
Query: 272 QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEK 330
+ I+YRDLK +N+LLD GHI+I+D G+ E G+ R GT Y+APE++ K
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 331 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 390
YTFS DWW G L+YEM+ G SPF E +E+ + I+ DT Y ++++K I
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580
Query: 391 MLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
L + P+KRLG G +K HP FK IN+ LE LEPPF P
Sbjct: 581 KLFEREPTKRLGVTG----NIKIHPFFKTINWTLLEKRRLEPPFRP 622
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 209 bits (533), Expect = 4e-54
Identities = 118/286 (41%), Positives = 167/286 (58%), Gaps = 12/286 (4%)
Query: 153 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE-KVQ 211
N F ++VLGKG FG+V +++ G+ +A K L+K + + EKR+L +
Sbjct: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
Query: 212 SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 271
+ F+ L ++TKD L V+ +NGGDL +HI + G F+ RA FYAAE+ CGL+ L
Sbjct: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFL 464
Query: 272 QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEK 330
+ I+YRDLK +N+LLD GHI+I+D G+ E G+ R GT Y+APE++ K
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 331 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 390
YTFS DWW G L+YEM+ G SPF E +E+ + I+ DT Y ++++K I
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580
Query: 391 MLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
L + P+KRLG G +K HP FK IN+ LE LEPPF P
Sbjct: 581 KLFEREPTKRLGVTG----NIKIHPFFKTINWTLLEKRRLEPPFRP 622
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 206 bits (523), Expect = 6e-53
Identities = 113/284 (39%), Positives = 165/284 (58%), Gaps = 8/284 (2%)
Query: 155 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR- 213
F VLGKG FG+V + T ++YA K L+K + + + EKR+L +
Sbjct: 339 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP 398
Query: 214 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 273
F+ L ++T D L V+ +NGGDL +HI +G F E +AVFYAAE+ GL L +
Sbjct: 399 FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAEISIGLFFLHK 456
Query: 274 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 332
I+YRDLK +N++LD GHI+I+D G+ E + +G R GT Y+APE++ + Y
Sbjct: 457 RGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYG 516
Query: 333 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 392
S DWW G L+YEM+ G PF E +E+ Q I Y + S++A SIC+ L
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKSLSKEAVSICKGL 572
Query: 393 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
+TK+P+KRLGC EG V++H F+ I++ +LE ++PPF P
Sbjct: 573 MTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP 616
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 206 bits (523), Expect = 6e-53
Identities = 112/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%)
Query: 155 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-QSR 213
F VLGKG FG+V + + T ++YA K L+K + + + EKR+L +
Sbjct: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401
Query: 214 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 273
F+ L ++T D L V+ +NGGDL +HI +G F E AVFYAAE+ GL LQ
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459
Query: 274 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 332
+ I+YRDLK +N++LD GHI+I+D G+ E I +G + GT Y+APE++ + Y
Sbjct: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519
Query: 333 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 392
S DWW G L+YEM+ G +PF+ E +E+ Q I Y + S++A +IC+ L
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 393 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
+TK+P KRLGC EG +K+H F+ I++ +LE ++PP+ P
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 206 bits (523), Expect = 6e-53
Identities = 112/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%)
Query: 155 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-QSR 213
F VLGKG FG+V + + T ++YA K L+K + + + EKR+L +
Sbjct: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401
Query: 214 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 273
F+ L ++T D L V+ +NGGDL +HI +G F E AVFYAAE+ GL LQ
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459
Query: 274 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 332
+ I+YRDLK +N++LD GHI+I+D G+ E I +G + GT Y+APE++ + Y
Sbjct: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519
Query: 333 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 392
S DWW G L+YEM+ G +PF+ E +E+ Q I Y + S++A +IC+ L
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 393 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
+TK+P KRLGC EG +K+H F+ I++ +LE ++PP+ P
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 205 bits (521), Expect = 1e-52
Identities = 120/296 (40%), Positives = 167/296 (56%), Gaps = 11/296 (3%)
Query: 145 LERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEK 204
L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK
Sbjct: 611 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 670
Query: 205 RILEKVQSR---FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYA 261
RIL V S F+V+L ++T + +C V+ GGDL HI++ F E RA+FY+
Sbjct: 671 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 727
Query: 262 AELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGY 320
A + GL+ L +IVYRDLK +N+LLD G+++I+D GL E + G R GT +
Sbjct: 728 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 787
Query: 321 MAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 380
+APEV+ + YT + DWWGLG L+YEM+ G SPF E EEV I ND Y
Sbjct: 788 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 843
Query: 381 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
S +A I R LL +NP +RLG A VK+ P F+ + + L A L PPF P
Sbjct: 844 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 899
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 205 bits (521), Expect = 1e-52
Identities = 120/296 (40%), Positives = 167/296 (56%), Gaps = 11/296 (3%)
Query: 145 LERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEK 204
L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK
Sbjct: 605 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 664
Query: 205 RILEKVQSR---FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYA 261
RIL V S F+V+L ++T + +C V+ GGDL HI++ F E RA+FY+
Sbjct: 665 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 721
Query: 262 AELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGY 320
A + GL+ L +IVYRDLK +N+LLD G+++I+D GL E + G R GT +
Sbjct: 722 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 781
Query: 321 MAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 380
+APEV+ + YT + DWWGLG L+YEM+ G SPF E EEV I ND Y
Sbjct: 782 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 837
Query: 381 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
S +A I R LL +NP +RLG A VK+ P F+ + + L A L PPF P
Sbjct: 838 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 893
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 204 bits (519), Expect = 2e-52
Identities = 123/286 (43%), Positives = 163/286 (56%), Gaps = 11/286 (3%)
Query: 155 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQS-- 212
FR VLG+G FG+V + + T +M+A K L+K I R + EKRI E V S
Sbjct: 657 FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR 716
Query: 213 -RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 271
F+V+L ++TK+ +C V+ GGDL HI+ F E RAVFYAA + GL+ L
Sbjct: 717 HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT---DVFSEPRAVFYAACVVLGLQYL 773
Query: 272 QRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEK 330
+IVYRDLK +N+LLD G ++I+D GL E + G R GT ++APEV+
Sbjct: 774 HEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS 833
Query: 331 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 390
YT + DWWGLG LIYEM+ G SPF E EEV I ND Y S +A SI R
Sbjct: 834 YTRAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRFLSTEAISIMR 889
Query: 391 MLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
LL +NP +RLG + A VK+HP F+ I++ L ++PPF P
Sbjct: 890 RLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIP 935
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 201 bits (511), Expect = 1e-51
Identities = 113/287 (39%), Positives = 167/287 (58%), Gaps = 7/287 (2%)
Query: 151 TKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV 210
T N F + ++LGKG FG+V + +A+GK YA K L+K+ I + A L E R+L+
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 211 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLED 270
+ F+ SL Y+++TKD LC V+ +NGG+L FH+ F E R FY AE+ L+
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR--ERVFSEDRTRFYGAEIVSALDY 261
Query: 271 LQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNE 329
L +IVYRDLK EN++LD GHI+I+D GL E I + ++ GT Y+APEV+ +
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
Query: 330 KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSIC 389
Y + DWWGLG ++YEM+ G PF E++ + I + ++ S DAKS+
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 390 RMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
LL K+P+KRLG + A + +H F +N++ + L PPF P
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 201 bits (511), Expect = 1e-51
Identities = 113/287 (39%), Positives = 167/287 (58%), Gaps = 7/287 (2%)
Query: 151 TKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV 210
T N F + ++LGKG FG+V + +A+GK YA K L+K+ I + A L E R+L+
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 211 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLED 270
+ F+ SL Y+++TKD LC V+ +NGG+L FH+ F E R FY AE+ L+
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR--ERVFSEDRTRFYGAEIVSALDY 261
Query: 271 LQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNE 329
L +IVYRDLK EN++LD GHI+I+D GL E I + ++ GT Y+APEV+ +
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
Query: 330 KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSIC 389
Y + DWWGLG ++YEM+ G PF E++ + I + ++ S DAKS+
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 390 RMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
LL K+P+KRLG + A + +H F +N++ + L PPF P
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 201 bits (510), Expect = 2e-51
Identities = 114/287 (39%), Positives = 163/287 (56%), Gaps = 9/287 (3%)
Query: 153 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQS 212
+ F RVLGKG FG+V +V+ TG +YA K L+K I + + EKRIL ++
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412
Query: 213 R-FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 271
F+ L ++T D L V+ +NGGDL FHI + FDE RA FYAAE+ L L
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK--SRRFDEARARFYAAEIISALMFL 470
Query: 272 QRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEK 330
+ I+YRDLK +N+LLD GH +++D G+ E I G GT Y+APE++
Sbjct: 471 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 530
Query: 331 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 390
Y + DWW +G L+YEM+ GH+PF+ E +++ + I ND Y EDA I +
Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENE----DDLFEAILNDEVVYPTWLHEDATGILK 586
Query: 391 MLLTKNPSKRLGCRGEGAA-GVKQHPVFKDINFRRLEANMLEPPFCP 436
+TKNP+ RLG +G + +HP FK+I++ +L +EPPF P
Sbjct: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 633
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 199 bits (505), Expect = 7e-51
Identities = 114/291 (39%), Positives = 165/291 (56%), Gaps = 7/291 (2%)
Query: 147 RQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRI 206
R VT N F + ++LGKG FG+V + +ATG+ YA K L+K+ I + A + E R+
Sbjct: 144 RAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRV 203
Query: 207 LEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCC 266
L+ + F+ +L YA++T D LC V+ NGG+L FH+ F E+RA FY AE+
Sbjct: 204 LQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVS 261
Query: 267 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEV 325
LE L +VYRD+K EN++LD GHI+I+D GL E I +G ++ GT Y+APEV
Sbjct: 262 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 321
Query: 326 VNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDA 385
+ + Y + DWWGLG ++YEM+ G PF E + + I + + S +A
Sbjct: 322 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----ERLFELILMEEIRFPRTLSPEA 377
Query: 386 KSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
KS+ LL K+P +RLG A V +H F IN++ + L PPF P
Sbjct: 378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 428
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 197 bits (500), Expect = 3e-50
Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 150 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 209
VT N F + ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E R+L+
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 210 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 269
+ F+ +L Y+++T D LC V+ NGG+L FH+ F E RA FY AE+ L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262
Query: 270 DLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 327
L E+ +VYRDLK EN++LD GHI+I+D GL E I +G ++ GT Y+APEV+
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 328 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 387
+ Y + DWWGLG ++YEM+ G PF E++ + I + + +AKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKS 378
Query: 388 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
+ LL K+P +RLG E A + QH F I ++ + L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 197 bits (500), Expect = 3e-50
Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 150 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 209
VT N F + ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E R+L+
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 210 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 269
+ F+ +L Y+++T D LC V+ NGG+L FH+ F E RA FY AE+ L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262
Query: 270 DLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 327
L E+ +VYRDLK EN++LD GHI+I+D GL E I +G ++ GT Y+APEV+
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 328 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 387
+ Y + DWWGLG ++YEM+ G PF E++ + I + + +AKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKS 378
Query: 388 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
+ LL K+P +RLG E A + QH F I ++ + L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 197 bits (500), Expect = 3e-50
Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 150 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 209
VT N F + ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E R+L+
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 210 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 269
+ F+ +L Y+++T D LC V+ NGG+L FH+ F E RA FY AE+ L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262
Query: 270 DLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 327
L E+ +VYRDLK EN++LD GHI+I+D GL E I +G ++ GT Y+APEV+
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 328 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 387
+ Y + DWWGLG ++YEM+ G PF E++ + I + + +AKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKS 378
Query: 388 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
+ LL K+P +RLG E A + QH F I ++ + L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 196 bits (497), Expect = 6e-50
Identities = 109/281 (38%), Positives = 160/281 (56%), Gaps = 12/281 (4%)
Query: 158 YRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-QSRFVV 216
+++LGKG FG+V + + T + +A K L+K + + EKR+L + F+
Sbjct: 383 HKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLT 442
Query: 217 SLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERI 276
+ ++TK+ L V+ +NGGDL +HI + FD RA FYAAE+ GL+ L + I
Sbjct: 443 HMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK--FDLSRATFYAAEIILGLQFLHSKGI 500
Query: 277 VYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEKYTFSP 335
VYRDLK +NILLD GHI+I+D G+ E G + GT Y+APE++ +KY S
Sbjct: 501 VYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSV 560
Query: 336 DWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTK 395
DWW G L+YEM+ G SPF E EE+ I+ D Y ++AK + L +
Sbjct: 561 DWWSFGVLLYEMLIGQSPFHGQDE----EELFHSIRMDNPFYPRWLEKEAKDLLVKLFVR 616
Query: 396 NPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
P KRLG RG+ ++QHP+F++IN+ LE ++PPF P
Sbjct: 617 EPEKRLGVRGD----IRQHPLFREINWEELERKEIDPPFRP 653
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 194 bits (494), Expect = 1e-49
Identities = 114/291 (39%), Positives = 158/291 (54%), Gaps = 13/291 (4%)
Query: 155 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV---- 210
F VLGKG FG+V + R + ++YA K L+K I + L EKR+L
Sbjct: 351 FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGP 410
Query: 211 --QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268
+ F+ L ++T D L V+ + GGDL +HI LG F E A FYAAE+ GL
Sbjct: 411 GGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGK--FKEPHAAFYAAEIAIGL 468
Query: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 327
L + I+YRDLK +N++LD GHI+I+D G+ E + G R GT Y+APE++
Sbjct: 469 FFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIA 528
Query: 328 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 387
+ Y S DWW G L+YEM+ G PF E EE+ Q I T Y + S +A +
Sbjct: 529 YQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDE----EELFQAIMEQTVTYPKSLSREAVA 584
Query: 388 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDP 438
IC+ LTK+P KRLG +G ++ H F+ I++ RLE + PPF P P
Sbjct: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRP 635
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 192 bits (487), Expect = 9e-49
Identities = 112/286 (39%), Positives = 162/286 (56%), Gaps = 10/286 (3%)
Query: 155 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR- 213
F +VLGKG FG+V +++ ++YA K L+K I + + EKRIL +
Sbjct: 408 FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP 467
Query: 214 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 273
++ L ++TKD L V+ +NGGDL F I + FDE R+ FYAAE+ L L +
Sbjct: 468 YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQR--SRKFDEPRSRFYAAEVTSALMFLHQ 525
Query: 274 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 332
++YRDLK +NILLD GH +++D G+ E I G GT Y+APE++ +Y
Sbjct: 526 HGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYG 585
Query: 333 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 392
S DWW LG L+YEM+ G PF+ E +++ + I +D Y S++A SI +
Sbjct: 586 PSVDWWALGVLMYEMMAGQPPFEADNE----DDLFESILHDDVLYPVWLSKEAVSILKAF 641
Query: 393 LTKNPSKRLGC--RGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
+TKNP KRLGC G +KQHP FK+I++ LE ++PPF P
Sbjct: 642 MTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKP 687
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 186 bits (473), Expect = 4e-47
Identities = 115/287 (40%), Positives = 166/287 (57%), Gaps = 11/287 (3%)
Query: 155 FRHYRVLGKGGFGEVCACQ-VRAT--GKMYACKKLQKKRI-KKRKGEAMALNEKRILEKV 210
F RVLGKGG+G+V + V+ T GK+YA K L+K +I + K A E+ ILE V
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 211 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLED 270
+ F+V LAYA++T L L+L ++GG+L H+ G F E A FY AE+ L
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGI--FLEDTACFYLAEITLALGH 184
Query: 271 LQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNE 329
L + I+YRDLKPENI+L +GHI+++D GL E I EG GT+ YMAPE++
Sbjct: 185 LHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRS 244
Query: 330 KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSIC 389
+ + DWW LG L+Y+M+ G PF K +++ R K Y + DA+ +
Sbjct: 245 GHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKI-IRGKLALPPY---LTPDARDLV 300
Query: 390 RMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 436
+ L +NPS+R+G AA V++HP F+ +N+ L A ++PPF P
Sbjct: 301 KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRP 347
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,163,067
Number of Sequences: 37866
Number of extensions: 1044299
Number of successful extensions: 4409
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 667
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 2210
Number of HSP's gapped (non-prelim): 943
length of query: 546
length of database: 18,247,518
effective HSP length: 107
effective length of query: 439
effective length of database: 14,195,856
effective search space: 6231980784
effective search space used: 6231980784
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.