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Search of human proteins with 51873043
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51873043 G protein-coupled receptor kinase 4 isoform alpha
[Homo sapiens]
(578 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [H... 1196 0.0
gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Ho... 1113 0.0
gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [H... 1080 0.0
gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens] 795 0.0
gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo ... 786 0.0
gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo ... 783 0.0
gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo ... 783 0.0
gi|4506529 rhodopsin kinase [Homo sapiens] 503 e-142
gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens] 493 e-139
gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens] 311 1e-84
gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens] 300 2e-81
gi|47157325 protein kinase C, delta [Homo sapiens] 209 4e-54
gi|31377782 protein kinase C, delta [Homo sapiens] 209 4e-54
gi|4506067 protein kinase C, alpha [Homo sapiens] 206 6e-53
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 206 6e-53
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 206 6e-53
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 205 1e-52
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 205 1e-52
gi|5453974 protein kinase N2 [Homo sapiens] 204 2e-52
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 201 2e-51
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 201 2e-51
gi|28557781 protein kinase C, eta [Homo sapiens] 201 2e-51
gi|4502023 AKT2 kinase [Homo sapiens] 199 8e-51
gi|62241015 AKT1 kinase [Homo sapiens] 197 3e-50
gi|62241013 AKT1 kinase [Homo sapiens] 197 3e-50
gi|62241011 AKT1 kinase [Homo sapiens] 197 3e-50
gi|5453976 protein kinase C, theta [Homo sapiens] 196 6e-50
gi|13384594 protein kinase C, gamma [Homo sapiens] 194 1e-49
gi|4885563 protein kinase C, epsilon [Homo sapiens] 192 9e-49
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 186 4e-47
>gi|51873043 G protein-coupled receptor kinase 4 isoform alpha [Homo
sapiens]
Length = 578
Score = 1196 bits (3094), Expect = 0.0
Identities = 578/578 (100%), Positives = 578/578 (100%)
Query: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
Query: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
Query: 541 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 578
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
Sbjct: 541 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 578
>gi|51873045 G protein-coupled receptor kinase 4 isoform beta [Homo
sapiens]
Length = 546
Score = 1113 bits (2879), Expect = 0.0
Identities = 546/578 (94%), Positives = 546/578 (94%), Gaps = 32/578 (5%)
Query: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
MELENIVANSLLLKARQ EKDYSSLCDKQ
Sbjct: 1 MELENIVANSLLLKARQ--------------------------------EKDYSSLCDKQ 28
Query: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
Sbjct: 29 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 88
Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
Sbjct: 89 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 148
Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
Sbjct: 149 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 208
Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
Sbjct: 209 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 268
Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
Sbjct: 269 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 328
Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
Sbjct: 329 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 388
Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
Sbjct: 389 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 448
Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
Sbjct: 449 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 508
Query: 541 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 578
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
Sbjct: 509 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 546
>gi|51873047 G protein-coupled receptor kinase 4 isoform gamma [Homo
sapiens]
Length = 532
Score = 1080 bits (2792), Expect = 0.0
Identities = 532/578 (92%), Positives = 532/578 (92%), Gaps = 46/578 (7%)
Query: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
Sbjct: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
Query: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
Sbjct: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
Sbjct: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
Sbjct: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
Sbjct: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
Sbjct: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
Sbjct: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
Sbjct: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE
Sbjct: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNE------------------------- 515
Query: 541 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC 578
GCLTMVPSEKEVEPKQC
Sbjct: 516 ---------------------GCLTMVPSEKEVEPKQC 532
>gi|4885349 G protein-coupled receptor kinase 5 [Homo sapiens]
Length = 590
Score = 795 bits (2053), Expect = 0.0
Identities = 381/560 (68%), Positives = 458/560 (81%), Gaps = 3/560 (0%)
Query: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
MELENIVAN++LLKAR+GG GK+ G+SKKWKEIL P +SQC +LR +I++DY SLCDKQ
Sbjct: 1 MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ 60
Query: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
PIGR LFRQFC+T+P L+ +I+FLD+VAEYEV DE + G I+ ++ K + +
Sbjct: 61 PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ 120
Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
+ D+V++ L ++ P K+ F C + H YLRGEPF EY +S +F +FLQWKWLERQ
Sbjct: 121 VGQDLVSQTEEKLLQK-PCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQ 179
Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACK+L+KKRIKKRKGE+MALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILE 239
Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
KV S+FVV+LAYAYETKDALCLVLTIMNGGDLKFHIYN+GNPGF+E+RA+FYAAE+ CGL
Sbjct: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299
Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
EDL RE VYRDLKPENILLDD GHIRISDLGLA +IPEG +RGRVGTVGYMAPEV+NN
Sbjct: 300 EDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNN 359
Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
++Y SPD+WGLGCLIYEMI+G SPF+ KEKVK EEVD+R+ E YS KFSE+AKSI
Sbjct: 360 QRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419
Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
C+MLLTK+ +RLGC+ EGAA VK+HP F+++NF+RLEA ML+PPF PDP AVYCKDVLD
Sbjct: 420 CKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLD 479
Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
IEQFS VKG+ LD D+DFY++F+TG VSIPWQNEMIE+ CFK++N LP DL++
Sbjct: 480 IEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNR 539
Query: 541 NIHTPVSRPNRGFFYRLFRR 560
N P P +G RLF+R
Sbjct: 540 N--HPPEPPKKGLLQRLFKR 557
>gi|51896039 G protein-coupled receptor kinase 6 isoform A [Homo
sapiens]
Length = 576
Score = 786 bits (2029), Expect = 0.0
Identities = 377/575 (65%), Positives = 450/575 (78%), Gaps = 2/575 (0%)
Query: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
MELENIVAN++LLKAR+GG G + G+SKKW+++L P +SQC ELR S+E+DY SLC++Q
Sbjct: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
PIGR LFR+FC T+P L R + FLD VAEYEV D+ R CG + F + +PE
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
+P +VT C L E+ P K F+E TR+ H YL PF +Y +S YF++FLQWKWLERQ
Sbjct: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179
Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239
Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G GF E RAVFYAAE+CCGL
Sbjct: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299
Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
EDL RERIVYRDLKPENILLDD GHIRISDLGLA +PEGQ ++GRVGTVGYMAPEVV N
Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359
Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K EEYSE+FS A+S+
Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419
Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
C LL K+P++RLGCRG A VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD
Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479
Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
IEQFS VKG+ L+ D+DFY +FATG V IPWQNEM+E+ CF+++N + ++P DLD
Sbjct: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDW 539
Query: 541 NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEP 575
P + P +G RLF R C +E P
Sbjct: 540 K-GQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELP 573
>gi|51896037 G protein-coupled receptor kinase 6 isoform C [Homo
sapiens]
Length = 560
Score = 783 bits (2022), Expect = 0.0
Identities = 374/560 (66%), Positives = 446/560 (79%), Gaps = 2/560 (0%)
Query: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
MELENIVAN++LLKAR+GG G + G+SKKW+++L P +SQC ELR S+E+DY SLC++Q
Sbjct: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
PIGR LFR+FC T+P L R + FLD VAEYEV D+ R CG + F + +PE
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
+P +VT C L E+ P K F+E TR+ H YL PF +Y +S YF++FLQWKWLERQ
Sbjct: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179
Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239
Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G GF E RAVFYAAE+CCGL
Sbjct: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299
Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
EDL RERIVYRDLKPENILLDD GHIRISDLGLA +PEGQ ++GRVGTVGYMAPEVV N
Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359
Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K EEYSE+FS A+S+
Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419
Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
C LL K+P++RLGCRG A VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD
Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479
Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
IEQFS VKG+ L+ D+DFY +FATG V IPWQNEM+E+ CF+++N + ++P DLD
Sbjct: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDW 539
Query: 541 NIHTPVSRPNRGFFYRLFRR 560
P + P +G RLF R
Sbjct: 540 K-GQPPAPPKKGLLQRLFSR 558
>gi|51896035 G protein-coupled receptor kinase 6 isoform B [Homo
sapiens]
Length = 589
Score = 783 bits (2022), Expect = 0.0
Identities = 374/560 (66%), Positives = 446/560 (79%), Gaps = 2/560 (0%)
Query: 1 MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
MELENIVAN++LLKAR+GG G + G+SKKW+++L P +SQC ELR S+E+DY SLC++Q
Sbjct: 1 MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQ 60
Query: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
PIGR LFR+FC T+P L R + FLD VAEYEV D+ R CG + F + +PE
Sbjct: 61 PIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPE 120
Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
+P +VT C L E+ P K F+E TR+ H YL PF +Y +S YF++FLQWKWLERQ
Sbjct: 121 VPRQLVTNCTQRL-EQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQ 179
Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
PVTKNTFR YRVLGKGGFGEVCACQVRATGKMYACKKL+KKRIKKRKGEAMALNEK+ILE
Sbjct: 180 PVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILE 239
Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
KV SRFVVSLAYAYETKDALCLVLT+MNGGDLKFHIY++G GF E RAVFYAAE+CCGL
Sbjct: 240 KVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGL 299
Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
EDL RERIVYRDLKPENILLDD GHIRISDLGLA +PEGQ ++GRVGTVGYMAPEVV N
Sbjct: 300 EDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKN 359
Query: 361 EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI 420
E+YTFSPDWW LGCL+YEMI G SPF++ K+K+K EEV++ +K EEYSE+FS A+S+
Sbjct: 360 ERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSL 419
Query: 421 CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD 480
C LL K+P++RLGCRG A VK+HP+FK +NF+RL A MLEPPF PDP A+YCKDVLD
Sbjct: 420 CSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLD 479
Query: 481 IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK 540
IEQFS VKG+ L+ D+DFY +FATG V IPWQNEM+E+ CF+++N + ++P DLD
Sbjct: 480 IEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDW 539
Query: 541 NIHTPVSRPNRGFFYRLFRR 560
P + P +G RLF R
Sbjct: 540 K-GQPPAPPKKGLLQRLFSR 558
>gi|4506529 rhodopsin kinase [Homo sapiens]
Length = 563
Score = 503 bits (1296), Expect = e-142
Identities = 259/541 (47%), Positives = 358/541 (66%), Gaps = 7/541 (1%)
Query: 3 LENIVANSLLLKARQGGYGKKS--GRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ 60
LE +VANS + AR G S R KK+ L LPP+S+C LR S+ ++ S+C +Q
Sbjct: 6 LETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQ 65
Query: 61 PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE 120
PIG++LF+QF + +E + +Y+ AD++ + +IL ++ + +
Sbjct: 66 PIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSF 125
Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
+ +V + + G E F+ + +L PF+EY S YF +FLQWKWLE Q
Sbjct: 126 LDEGIVAKFKEGPVEIQDG--LFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQ 183
Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
P+ ++ F +RVLGKGGFGEV ACQ++ATGK+YACKKL KKR+KKRKG A+ EK+IL
Sbjct: 184 PMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILM 243
Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLG--NPGFDEQRAVFYAAELCC 298
KV SRF+VSLAYA+ETK LCLV+TIMNGGD+++HIYN+ NPGF E RA+FY A++ C
Sbjct: 244 KVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIIC 303
Query: 299 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEV 357
GLE L + RIVYRDLKPEN+LLD+ G++RISDLGLA E+ +GQ + +G GT G+MAPE+
Sbjct: 304 GLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPEL 363
Query: 358 VNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDA 417
+ E+Y FS D++ LG +YEMI PF+ EKV+ +E+ RI ++ +Y +KFS+ +
Sbjct: 364 LQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQAS 423
Query: 418 KSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKD 477
K C LL K+P KRLG R E ++ HP+FKD+N+R+LEA ML PPF PD VY KD
Sbjct: 424 KDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKD 483
Query: 478 VLDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLD 537
+ D+ FS VKG+ D D +F+ FATG IPWQ EMIE+G F ++N S+ +P D
Sbjct: 484 IQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMPDD 543
Query: 538 L 538
+
Sbjct: 544 M 544
>gi|21166359 G-protein-coupled receptor kinase 7 [Homo sapiens]
Length = 553
Score = 493 bits (1270), Expect = e-139
Identities = 253/528 (47%), Positives = 348/528 (65%), Gaps = 7/528 (1%)
Query: 3 LENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQPI 62
L+N++AN+ L+AR+ S ++ + L LP + C+ELR + ++ SLC++QPI
Sbjct: 7 LDNLIANTAYLQARKPS-DCDSKELQRRRRSLALPGLQGCAELRQKLSLNFHSLCEQQPI 65
Query: 63 GRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAA--PLPE 120
GRRLFR F T PT ++ FL+ V +E+A++ D L L A P P
Sbjct: 66 GRRLFRDFLATVPTFRKAATFLEDVQNWELAEEGPTKDSALQGLVATCASAPAPGNPQPF 125
Query: 121 IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ 180
+ V T+C+ EE A A +L+ +PF+++ S+++ +FLQWK E Q
Sbjct: 126 LSQAVATKCQAATTEEE-RVAAVTLAKAEAMAFLQEQPFKDFVTSAFYDKFLQWKLFEMQ 184
Query: 181 PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE 240
PV+ F +RVLGKGGFGEVCA QV+ TGKMYACKKL KKR+KK+ GE MAL EK ILE
Sbjct: 185 PVSDKYFTEFRVLGKGGFGEVCAVQVKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILE 244
Query: 241 KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
KV S F+VSLAYA+E+K LCLV+++MNGGDLKFHIYN+G G D R +FY+A++ CG+
Sbjct: 245 KVSSPFIVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACGM 304
Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN 360
L IVYRD+KPEN+LLDD G+ R+SDLGLA E+ G+ + R GT GYMAPE++
Sbjct: 305 LHLHELGIVYRDMKPENVLLDDLGNCRLSDLGLAVEMKGGKPITQRAGTNGYMAPEILME 364
Query: 361 E-KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYS-EKFSEDAK 418
+ Y++ DW+ +GC IYEM+ G +PFK YKEKV E++ QR D ++ + F+E+AK
Sbjct: 365 KVSYSYPVDWFAMGCSIYEMVAGRTPFKDYKEKVSKEDLKQRTLQDEVKFQHDNFTEEAK 424
Query: 419 SICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDV 478
ICR+ L K P +RLG R E + ++H FK INF RLEA ++EPPF PDP VY KD+
Sbjct: 425 DICRLFLAKKPEQRLGSR-EKSDDPRKHHFFKTINFPRLEAGLIEPPFVPDPSVVYAKDI 483
Query: 479 LDIEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDIN 526
+I+ FS V+G+ D D+ F+ FATG V I WQ E+IE+G F+++N
Sbjct: 484 AEIDDFSEVRGVEFDDKDKQFFKNFATGAVPIAWQEEIIETGLFEELN 531
>gi|148539879 beta-adrenergic receptor kinase 2 [Homo sapiens]
Length = 688
Score = 311 bits (796), Expect = 1e-84
Identities = 193/530 (36%), Positives = 287/530 (54%), Gaps = 20/530 (3%)
Query: 2 ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59
+LE ++A+ L A + + R+ K + LP S S ++ + + DK
Sbjct: 3 DLEAVLADVSYLMAMEKSKATPAARASKR---IVLPEPSIRSVMQKYLAERNEITFDKIF 59
Query: 60 -QPIGRRLFRQFCDTKPT-LKRHIEFLDAVAEYEVADDEDRSDC-GLSILDRFFNDKLAA 116
Q IG LF+ FC + ++F + + EYE D+E+ C I D + +L +
Sbjct: 60 NQKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLS 119
Query: 117 PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKW 176
V + L ++ + F+ LRG+ F+++ ES F++F QWK
Sbjct: 120 CSHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKN 179
Query: 177 LERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNE 235
+E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++GE +ALNE
Sbjct: 180 VELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNE 239
Query: 236 KRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFY 292
+ +L V + F+V + YA+ T D LC +L +MNGGDL +H+ G F E+ FY
Sbjct: 240 RIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHG--VFSEKEMRFY 297
Query: 293 AAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGY 352
A E+ GLE + +VYRDLKP NILLD+ GH RISDLGLA + + ++ VGT GY
Sbjct: 298 ATEIILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSK-KKPHASVGTHGY 356
Query: 353 MAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSE 411
MAPEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+ E +
Sbjct: 357 MAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLTVNVELPD 415
Query: 412 KFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPH 471
FS + KS+ LL ++ SKRLGC G G+ VK+H FK ++++ + PP P
Sbjct: 416 TFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRG 475
Query: 472 AVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIES 519
V D DI F KGI L D++ Y F +S WQ E+ E+
Sbjct: 476 EVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPL-VISERWQQEVTET 524
>gi|148539876 beta-adrenergic receptor kinase 1 [Homo sapiens]
Length = 689
Score = 300 bits (769), Expect = 2e-81
Identities = 198/544 (36%), Positives = 298/544 (54%), Gaps = 35/544 (6%)
Query: 2 ELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDK-- 59
+LE ++A+ L A + + R+ K + LP S S ++ +E +K
Sbjct: 3 DLEAVLADVSYLMAMEKSKATPAARASKK---ILLPEPSIRSVMQKYLEDRGEVTFEKIF 59
Query: 60 -QPIGRRLFRQFC-----DTKPTLKRHIEFLDAVAEYEVAD-DEDRSDCGLSILDRFFND 112
Q +G LFR FC + +P +EF + + +YE + +E+R I D +
Sbjct: 60 SQKLGYLLFRDFCLNHLEEARPL----VEFYEEIKKYEKLETEEERVARSREIFDSYIMK 115
Query: 113 KLAA---PLPEIPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFS 169
+L A P + + V + LG K+ P F+ LRG+ F+++ ES F+
Sbjct: 116 ELLACSHPFSKSATEHV-QGHLGKKQVPPD--LFQPYIEEICQNLRGDVFQKFIESDKFT 172
Query: 170 QFLQWKWLERQ-PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKG 228
+F QWK +E +T N F +R++G+GGFGEV C+ TGKMYA K L KKRIK ++G
Sbjct: 173 RFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG 232
Query: 229 EAMALNEKRILEKVQS---RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFD 285
E +ALNE+ +L V + F+V ++YA+ T D L +L +MNGGDL +H+ G F
Sbjct: 233 ETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFS 290
Query: 286 EQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRG 345
E FYAAE+ GLE + +VYRDLKP NILLD+ GH+RISDLGLA + + ++
Sbjct: 291 EADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSK-KKPHA 349
Query: 346 RVGTVGYMAPEVV-NNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKN 404
VGT GYMAPEV+ Y S DW+ LGC+++++++GHSPF+++K K K E+D+
Sbjct: 350 SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDK-HEIDRMTLT 408
Query: 405 DTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEP 464
E + FS + +S+ LL ++ ++RLGC G GA VK+ P F+ ++++ + P
Sbjct: 409 MAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPP 468
Query: 465 PFCPDPHAVYCKDVLDIEQFSV--VKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCF 522
P P V D DI F KGI L +D++ Y F +S WQ E+ E+ F
Sbjct: 469 PLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPL-TISERWQQEVAET-VF 526
Query: 523 KDIN 526
IN
Sbjct: 527 DTIN 530
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 209 bits (533), Expect = 4e-54
Identities = 118/286 (41%), Positives = 167/286 (58%), Gaps = 12/286 (4%)
Query: 185 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE-KVQ 243
N F ++VLGKG FG+V +++ G+ +A K L+K + + EKR+L +
Sbjct: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
Query: 244 SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 303
+ F+ L ++TKD L V+ +NGGDL +HI + G F+ RA FYAAE+ CGL+ L
Sbjct: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFL 464
Query: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEK 362
+ I+YRDLK +N+LLD GHI+I+D G+ E G+ R GT Y+APE++ K
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 422
YTFS DWW G L+YEM+ G SPF E +E+ + I+ DT Y ++++K I
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580
Query: 423 MLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
L + P+KRLG G +K HP FK IN+ LE LEPPF P
Sbjct: 581 KLFEREPTKRLGVTG----NIKIHPFFKTINWTLLEKRRLEPPFRP 622
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 209 bits (533), Expect = 4e-54
Identities = 118/286 (41%), Positives = 167/286 (58%), Gaps = 12/286 (4%)
Query: 185 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE-KVQ 243
N F ++VLGKG FG+V +++ G+ +A K L+K + + EKR+L +
Sbjct: 347 NNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAE 406
Query: 244 SRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 303
+ F+ L ++TKD L V+ +NGGDL +HI + G F+ RA FYAAE+ CGL+ L
Sbjct: 407 NPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGR--FELYRATFYAAEIMCGLQFL 464
Query: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEK 362
+ I+YRDLK +N+LLD GHI+I+D G+ E G+ R GT Y+APE++ K
Sbjct: 465 HSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLK 524
Query: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 422
YTFS DWW G L+YEM+ G SPF E +E+ + I+ DT Y ++++K I
Sbjct: 525 YTFSVDWWSFGVLLYEMLIGQSPFHGDDE----DELFESIRVDTPHYPRWITKESKDILE 580
Query: 423 MLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
L + P+KRLG G +K HP FK IN+ LE LEPPF P
Sbjct: 581 KLFEREPTKRLGVTG----NIKIHPFFKTINWTLLEKRRLEPPFRP 622
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 206 bits (523), Expect = 6e-53
Identities = 113/284 (39%), Positives = 165/284 (58%), Gaps = 8/284 (2%)
Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR- 245
F VLGKG FG+V + T ++YA K L+K + + + EKR+L +
Sbjct: 339 FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP 398
Query: 246 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 305
F+ L ++T D L V+ +NGGDL +HI +G F E +AVFYAAE+ GL L +
Sbjct: 399 FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVFYAAEISIGLFFLHK 456
Query: 306 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 364
I+YRDLK +N++LD GHI+I+D G+ E + +G R GT Y+APE++ + Y
Sbjct: 457 RGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYG 516
Query: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424
S DWW G L+YEM+ G PF E +E+ Q I Y + S++A SIC+ L
Sbjct: 517 KSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKSLSKEAVSICKGL 572
Query: 425 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
+TK+P+KRLGC EG V++H F+ I++ +LE ++PPF P
Sbjct: 573 MTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKP 616
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 206 bits (523), Expect = 6e-53
Identities = 112/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%)
Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-QSR 245
F VLGKG FG+V + + T ++YA K L+K + + + EKR+L +
Sbjct: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401
Query: 246 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 305
F+ L ++T D L V+ +NGGDL +HI +G F E AVFYAAE+ GL LQ
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459
Query: 306 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 364
+ I+YRDLK +N++LD GHI+I+D G+ E I +G + GT Y+APE++ + Y
Sbjct: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519
Query: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424
S DWW G L+YEM+ G +PF+ E +E+ Q I Y + S++A +IC+ L
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 425 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
+TK+P KRLGC EG +K+H F+ I++ +LE ++PP+ P
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 206 bits (523), Expect = 6e-53
Identities = 112/284 (39%), Positives = 167/284 (58%), Gaps = 8/284 (2%)
Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-QSR 245
F VLGKG FG+V + + T ++YA K L+K + + + EKR+L +
Sbjct: 342 FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP 401
Query: 246 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 305
F+ L ++T D L V+ +NGGDL +HI +G F E AVFYAAE+ GL LQ
Sbjct: 402 FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIGLFFLQS 459
Query: 306 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 364
+ I+YRDLK +N++LD GHI+I+D G+ E I +G + GT Y+APE++ + Y
Sbjct: 460 KGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYG 519
Query: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424
S DWW G L+YEM+ G +PF+ E +E+ Q I Y + S++A +IC+ L
Sbjct: 520 KSVDWWAFGVLLYEMLAGQAPFEGEDE----DELFQSIMEHNVAYPKSMSKEAVAICKGL 575
Query: 425 LTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
+TK+P KRLGC EG +K+H F+ I++ +LE ++PP+ P
Sbjct: 576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKP 619
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 205 bits (521), Expect = 1e-52
Identities = 120/296 (40%), Positives = 167/296 (56%), Gaps = 11/296 (3%)
Query: 177 LERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEK 236
L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK
Sbjct: 611 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 670
Query: 237 RILEKVQSR---FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYA 293
RIL V S F+V+L ++T + +C V+ GGDL HI++ F E RA+FY+
Sbjct: 671 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 727
Query: 294 AELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGY 352
A + GL+ L +IVYRDLK +N+LLD G+++I+D GL E + G R GT +
Sbjct: 728 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 787
Query: 353 MAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 412
+APEV+ + YT + DWWGLG L+YEM+ G SPF E EEV I ND Y
Sbjct: 788 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 843
Query: 413 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
S +A I R LL +NP +RLG A VK+ P F+ + + L A L PPF P
Sbjct: 844 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 899
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 205 bits (521), Expect = 1e-52
Identities = 120/296 (40%), Positives = 167/296 (56%), Gaps = 11/296 (3%)
Query: 177 LERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEK 236
L + P+T F+ VLG+G FG+V + R +G+++A K L+K I R + EK
Sbjct: 605 LRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEK 664
Query: 237 RILEKVQSR---FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYA 293
RIL V S F+V+L ++T + +C V+ GGDL HI++ F E RA+FY+
Sbjct: 665 RILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS---DVFSEPRAIFYS 721
Query: 294 AELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGY 352
A + GL+ L +IVYRDLK +N+LLD G+++I+D GL E + G R GT +
Sbjct: 722 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 781
Query: 353 MAPEVVNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEK 412
+APEV+ + YT + DWWGLG L+YEM+ G SPF E EEV I ND Y
Sbjct: 782 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRF 837
Query: 413 FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
S +A I R LL +NP +RLG A VK+ P F+ + + L A L PPF P
Sbjct: 838 LSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 893
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 204 bits (519), Expect = 2e-52
Identities = 123/286 (43%), Positives = 163/286 (56%), Gaps = 11/286 (3%)
Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQS-- 244
FR VLG+G FG+V + + T +M+A K L+K I R + EKRI E V S
Sbjct: 657 FRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFETVNSVR 716
Query: 245 -RFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 303
F+V+L ++TK+ +C V+ GGDL HI+ F E RAVFYAA + GL+ L
Sbjct: 717 HPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHT---DVFSEPRAVFYAACVVLGLQYL 773
Query: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEK 362
+IVYRDLK +N+LLD G ++I+D GL E + G R GT ++APEV+
Sbjct: 774 HEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS 833
Query: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 422
YT + DWWGLG LIYEM+ G SPF E EEV I ND Y S +A SI R
Sbjct: 834 YTRAVDWWGLGVLIYEMLVGESPFPGDDE----EEVFDSIVNDEVRYPRFLSTEAISIMR 889
Query: 423 MLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
LL +NP +RLG + A VK+HP F+ I++ L ++PPF P
Sbjct: 890 RLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIP 935
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 201 bits (511), Expect = 2e-51
Identities = 113/287 (39%), Positives = 167/287 (58%), Gaps = 7/287 (2%)
Query: 183 TKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV 242
T N F + ++LGKG FG+V + +A+GK YA K L+K+ I + A L E R+L+
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 243 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLED 302
+ F+ SL Y+++TKD LC V+ +NGG+L FH+ F E R FY AE+ L+
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR--ERVFSEDRTRFYGAEIVSALDY 261
Query: 303 LQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNE 361
L +IVYRDLK EN++LD GHI+I+D GL E I + ++ GT Y+APEV+ +
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
Query: 362 KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSIC 421
Y + DWWGLG ++YEM+ G PF E++ + I + ++ S DAKS+
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 422 RMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
LL K+P+KRLG + A + +H F +N++ + L PPF P
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 201 bits (511), Expect = 2e-51
Identities = 113/287 (39%), Positives = 167/287 (58%), Gaps = 7/287 (2%)
Query: 183 TKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV 242
T N F + ++LGKG FG+V + +A+GK YA K L+K+ I + A L E R+L+
Sbjct: 144 TMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNT 203
Query: 243 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLED 302
+ F+ SL Y+++TKD LC V+ +NGG+L FH+ F E R FY AE+ L+
Sbjct: 204 RHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSR--ERVFSEDRTRFYGAEIVSALDY 261
Query: 303 LQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNE 361
L +IVYRDLK EN++LD GHI+I+D GL E I + ++ GT Y+APEV+ +
Sbjct: 262 LHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDN 321
Query: 362 KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSIC 421
Y + DWWGLG ++YEM+ G PF E++ + I + ++ S DAKS+
Sbjct: 322 DYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEDIKFPRTLSSDAKSLL 377
Query: 422 RMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
LL K+P+KRLG + A + +H F +N++ + L PPF P
Sbjct: 378 SGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKP 424
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 201 bits (510), Expect = 2e-51
Identities = 114/287 (39%), Positives = 163/287 (56%), Gaps = 9/287 (3%)
Query: 185 NTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQS 244
+ F RVLGKG FG+V +V+ TG +YA K L+K I + + EKRIL ++
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412
Query: 245 R-FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 303
F+ L ++T D L V+ +NGGDL FHI + FDE RA FYAAE+ L L
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK--SRRFDEARARFYAAEIISALMFL 470
Query: 304 QRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEK 362
+ I+YRDLK +N+LLD GH +++D G+ E I G GT Y+APE++
Sbjct: 471 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEML 530
Query: 363 YTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICR 422
Y + DWW +G L+YEM+ GH+PF+ E +++ + I ND Y EDA I +
Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENE----DDLFEAILNDEVVYPTWLHEDATGILK 586
Query: 423 MLLTKNPSKRLGCRGEGAA-GVKQHPVFKDINFRRLEANMLEPPFCP 468
+TKNP+ RLG +G + +HP FK+I++ +L +EPPF P
Sbjct: 587 SFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 633
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 199 bits (505), Expect = 8e-51
Identities = 114/291 (39%), Positives = 165/291 (56%), Gaps = 7/291 (2%)
Query: 179 RQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRI 238
R VT N F + ++LGKG FG+V + +ATG+ YA K L+K+ I + A + E R+
Sbjct: 144 RAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRV 203
Query: 239 LEKVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCC 298
L+ + F+ +L YA++T D LC V+ NGG+L FH+ F E+RA FY AE+
Sbjct: 204 LQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR--ERVFTEERARFYGAEIVS 261
Query: 299 GLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEV 357
LE L +VYRD+K EN++LD GHI+I+D GL E I +G ++ GT Y+APEV
Sbjct: 262 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEV 321
Query: 358 VNNEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDA 417
+ + Y + DWWGLG ++YEM+ G PF E + + I + + S +A
Sbjct: 322 LEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----ERLFELILMEEIRFPRTLSPEA 377
Query: 418 KSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
KS+ LL K+P +RLG A V +H F IN++ + L PPF P
Sbjct: 378 KSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 428
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 197 bits (500), Expect = 3e-50
Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 182 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 241
VT N F + ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E R+L+
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 242 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301
+ F+ +L Y+++T D LC V+ NGG+L FH+ F E RA FY AE+ L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262
Query: 302 DLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 359
L E+ +VYRDLK EN++LD GHI+I+D GL E I +G ++ GT Y+APEV+
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 360 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419
+ Y + DWWGLG ++YEM+ G PF E++ + I + + +AKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKS 378
Query: 420 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
+ LL K+P +RLG E A + QH F I ++ + L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 197 bits (500), Expect = 3e-50
Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 182 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 241
VT N F + ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E R+L+
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 242 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301
+ F+ +L Y+++T D LC V+ NGG+L FH+ F E RA FY AE+ L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262
Query: 302 DLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 359
L E+ +VYRDLK EN++LD GHI+I+D GL E I +G ++ GT Y+APEV+
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 360 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419
+ Y + DWWGLG ++YEM+ G PF E++ + I + + +AKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKS 378
Query: 420 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
+ LL K+P +RLG E A + QH F I ++ + L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 197 bits (500), Expect = 3e-50
Identities = 113/289 (39%), Positives = 165/289 (57%), Gaps = 8/289 (2%)
Query: 182 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 241
VT N F + ++LGKG FG+V + +ATG+ YA K L+K+ I + A L E R+L+
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN 204
Query: 242 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301
+ F+ +L Y+++T D LC V+ NGG+L FH+ F E RA FY AE+ L+
Sbjct: 205 SRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSR--ERVFSEDRARFYGAEIVSALD 262
Query: 302 DLQRER-IVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 359
L E+ +VYRDLK EN++LD GHI+I+D GL E I +G ++ GT Y+APEV+
Sbjct: 263 YLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLE 322
Query: 360 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419
+ Y + DWWGLG ++YEM+ G PF E++ + I + + +AKS
Sbjct: 323 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH----EKLFELILMEEIRFPRTLGPEAKS 378
Query: 420 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
+ LL K+P +RLG E A + QH F I ++ + L PPF P
Sbjct: 379 LLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 427
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 196 bits (497), Expect = 6e-50
Identities = 109/281 (38%), Positives = 160/281 (56%), Gaps = 12/281 (4%)
Query: 190 YRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV-QSRFVV 248
+++LGKG FG+V + + T + +A K L+K + + EKR+L + F+
Sbjct: 383 HKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLT 442
Query: 249 SLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERI 308
+ ++TK+ L V+ +NGGDL +HI + FD RA FYAAE+ GL+ L + I
Sbjct: 443 HMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHK--FDLSRATFYAAEIILGLQFLHSKGI 500
Query: 309 VYRDLKPENILLDDRGHIRISDLGLATEIPEGQ-RVRGRVGTVGYMAPEVVNNEKYTFSP 367
VYRDLK +NILLD GHI+I+D G+ E G + GT Y+APE++ +KY S
Sbjct: 501 VYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSV 560
Query: 368 DWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTK 427
DWW G L+YEM+ G SPF E EE+ I+ D Y ++AK + L +
Sbjct: 561 DWWSFGVLLYEMLIGQSPFHGQDE----EELFHSIRMDNPFYPRWLEKEAKDLLVKLFVR 616
Query: 428 NPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
P KRLG RG+ ++QHP+F++IN+ LE ++PPF P
Sbjct: 617 EPEKRLGVRGD----IRQHPLFREINWEELERKEIDPPFRP 653
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 194 bits (494), Expect = 1e-49
Identities = 114/291 (39%), Positives = 158/291 (54%), Gaps = 13/291 (4%)
Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKV---- 242
F VLGKG FG+V + R + ++YA K L+K I + L EKR+L
Sbjct: 351 FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGP 410
Query: 243 --QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL 300
+ F+ L ++T D L V+ + GGDL +HI LG F E A FYAAE+ GL
Sbjct: 411 GGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGK--FKEPHAAFYAAEIAIGL 468
Query: 301 EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVN 359
L + I+YRDLK +N++LD GHI+I+D G+ E + G R GT Y+APE++
Sbjct: 469 FFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIA 528
Query: 360 NEKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKS 419
+ Y S DWW G L+YEM+ G PF E EE+ Q I T Y + S +A +
Sbjct: 529 YQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDE----EELFQAIMEQTVTYPKSLSREAVA 584
Query: 420 ICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDP 470
IC+ LTK+P KRLG +G ++ H F+ I++ RLE + PPF P P
Sbjct: 585 ICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRP 635
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 192 bits (487), Expect = 9e-49
Identities = 112/286 (39%), Positives = 162/286 (56%), Gaps = 10/286 (3%)
Query: 187 FRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSR- 245
F +VLGKG FG+V +++ ++YA K L+K I + + EKRIL +
Sbjct: 408 FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP 467
Query: 246 FVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQR 305
++ L ++TKD L V+ +NGGDL F I + FDE R+ FYAAE+ L L +
Sbjct: 468 YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQR--SRKFDEPRSRFYAAEVTSALMFLHQ 525
Query: 306 ERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNEKYT 364
++YRDLK +NILLD GH +++D G+ E I G GT Y+APE++ +Y
Sbjct: 526 HGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYG 585
Query: 365 FSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRML 424
S DWW LG L+YEM+ G PF+ E +++ + I +D Y S++A SI +
Sbjct: 586 PSVDWWALGVLMYEMMAGQPPFEADNE----DDLFESILHDDVLYPVWLSKEAVSILKAF 641
Query: 425 LTKNPSKRLGC--RGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
+TKNP KRLGC G +KQHP FK+I++ LE ++PPF P
Sbjct: 642 MTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKP 687
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 186 bits (473), Expect = 4e-47
Identities = 115/287 (40%), Positives = 166/287 (57%), Gaps = 11/287 (3%)
Query: 187 FRHYRVLGKGGFGEVCACQ-VRAT--GKMYACKKLQKKRI-KKRKGEAMALNEKRILEKV 242
F RVLGKGG+G+V + V+ T GK+YA K L+K +I + K A E+ ILE V
Sbjct: 67 FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126
Query: 243 QSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLED 302
+ F+V LAYA++T L L+L ++GG+L H+ G F E A FY AE+ L
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGI--FLEDTACFYLAEITLALGH 184
Query: 303 LQRERIVYRDLKPENILLDDRGHIRISDLGLATE-IPEGQRVRGRVGTVGYMAPEVVNNE 361
L + I+YRDLKPENI+L +GHI+++D GL E I EG GT+ YMAPE++
Sbjct: 185 LHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRS 244
Query: 362 KYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSIC 421
+ + DWW LG L+Y+M+ G PF K +++ R K Y + DA+ +
Sbjct: 245 GHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKI-IRGKLALPPY---LTPDARDLV 300
Query: 422 RMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCP 468
+ L +NPS+R+G AA V++HP F+ +N+ L A ++PPF P
Sbjct: 301 KKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRP 347
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,802,666
Number of Sequences: 37866
Number of extensions: 1127256
Number of successful extensions: 4584
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 661
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 2395
Number of HSP's gapped (non-prelim): 936
length of query: 578
length of database: 18,247,518
effective HSP length: 108
effective length of query: 470
effective length of database: 14,157,990
effective search space: 6654255300
effective search space used: 6654255300
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.