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Search of human proteins with 5174469
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B
precursor [Homo sapiens]
(441 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor... 889 0.0
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform... 372 e-103
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform... 372 e-103
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform... 356 2e-98
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens] 210 2e-54
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens] 199 4e-51
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens] 172 4e-43
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [... 171 9e-43
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H... 162 4e-40
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ... 159 4e-39
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec... 159 5e-39
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens] 158 1e-38
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens] 148 8e-36
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec... 147 2e-35
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens] 147 2e-35
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [... 144 1e-34
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi... 137 3e-32
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr... 129 5e-30
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec... 128 9e-30
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ... 125 1e-28
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec... 124 2e-28
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p... 122 8e-28
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre... 115 6e-26
gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens] 97 4e-20
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens] 96 8e-20
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 82 7e-16
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 82 7e-16
gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 82 7e-16
gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 82 7e-16
gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 82 7e-16
>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
[Homo sapiens]
Length = 441
Score = 889 bits (2296), Expect = 0.0
Identities = 441/441 (100%), Positives = 441/441 (100%)
Query: 1 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY 60
MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY
Sbjct: 1 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY 60
Query: 61 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII 120
LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII
Sbjct: 61 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII 120
Query: 121 NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV 180
NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV
Sbjct: 121 NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV 180
Query: 181 EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL 240
EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL
Sbjct: 181 EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL 240
Query: 241 VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP 300
VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP
Sbjct: 241 VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP 300
Query: 301 LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA 360
LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA
Sbjct: 301 LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA 360
Query: 361 VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY 420
VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY
Sbjct: 361 VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY 420
Query: 421 LFMLGIYTITLCSLWALWGGV 441
LFMLGIYTITLCSLWALWGGV
Sbjct: 421 LFMLGIYTITLCSLWALWGGV 441
>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
precursor [Homo sapiens]
Length = 484
Score = 372 bits (955), Expect = e-103
Identities = 191/449 (42%), Positives = 278/449 (61%), Gaps = 47/449 (10%)
Query: 31 ALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWND 90
AL LS LL Y K VRPV +W K TTV +D+ V+AIL+VD +NQ+L T +WY++ W D
Sbjct: 39 ALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTD 98
Query: 91 EFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQ 150
EFL WN FD I ++S+P +IW PDI+INEFVD+ + P++PYVY+ G ++NYKP+Q
Sbjct: 99 EFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQ 158
Query: 151 VVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELL 210
VV+ACSL+ Y FPFDVQNCSLTF S LHT++D++++ R PE ++ D+ F+N EWELL
Sbjct: 159 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 218
Query: 211 SVSSTY-SILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRA 269
V + S+ +A+++F VV+RR PL YVVSLL+PSIFLM++D+ FYLPPN
Sbjct: 219 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 278
Query: 270 RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHD 329
R+ FK ++L+GY+VF + +S+ +P + TPLIG +F +CMA LV+SLA++I +V+ +H
Sbjct: 279 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHK 338
Query: 330 EQRGGQEQP---------------FLCLRGDTDADRPRVEPRAQRAVVTES-SLYGEHLA 373
+ +QP LCLR + + RP P +A T+ S G H +
Sbjct: 339 QD---LQQPVPAWLRHLVLERIAWLLCLREQSTSQRP---PATSQATKTDDCSAMGNHCS 392
Query: 374 QPGTLKE------------------------VWSQLQSISNYLQTQDQTDQQEAEWLVLL 409
G ++ + +L SI +L+ +D+ + +WL +
Sbjct: 393 HMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVG 452
Query: 410 SRFDRLLFQSYLFMLGIYTITLCSLWALW 438
S D+LLF YL + Y+ITL LW++W
Sbjct: 453 SVLDKLLFHIYLLAVLAYSITLVMLWSIW 481
>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
[Homo sapiens]
Length = 463
Score = 372 bits (955), Expect = e-103
Identities = 191/449 (42%), Positives = 278/449 (61%), Gaps = 47/449 (10%)
Query: 31 ALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWND 90
AL LS LL Y K VRPV +W K TTV +D+ V+AIL+VD +NQ+L T +WY++ W D
Sbjct: 18 ALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTD 77
Query: 91 EFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQ 150
EFL WN FD I ++S+P +IW PDI+INEFVD+ + P++PYVY+ G ++NYKP+Q
Sbjct: 78 EFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQ 137
Query: 151 VVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELL 210
VV+ACSL+ Y FPFDVQNCSLTF S LHT++D++++ R PE ++ D+ F+N EWELL
Sbjct: 138 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 197
Query: 211 SVSSTY-SILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRA 269
V + S+ +A+++F VV+RR PL YVVSLL+PSIFLM++D+ FYLPPN
Sbjct: 198 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 257
Query: 270 RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHD 329
R+ FK ++L+GY+VF + +S+ +P + TPLIG +F +CMA LV+SLA++I +V+ +H
Sbjct: 258 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHK 317
Query: 330 EQRGGQEQP---------------FLCLRGDTDADRPRVEPRAQRAVVTES-SLYGEHLA 373
+ +QP LCLR + + RP P +A T+ S G H +
Sbjct: 318 QD---LQQPVPAWLRHLVLERIAWLLCLREQSTSQRP---PATSQATKTDDCSAMGNHCS 371
Query: 374 QPGTLKE------------------------VWSQLQSISNYLQTQDQTDQQEAEWLVLL 409
G ++ + +L SI +L+ +D+ + +WL +
Sbjct: 372 HMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVG 431
Query: 410 SRFDRLLFQSYLFMLGIYTITLCSLWALW 438
S D+LLF YL + Y+ITL LW++W
Sbjct: 432 SVLDKLLFHIYLLAVLAYSITLVMLWSIW 460
>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
precursor [Homo sapiens]
Length = 516
Score = 356 bits (914), Expect = 2e-98
Identities = 191/481 (39%), Positives = 278/481 (57%), Gaps = 79/481 (16%)
Query: 31 ALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWND 90
AL LS LL Y K VRPV +W K TTV +D+ V+AIL+VD +NQ+L T +WY++ W D
Sbjct: 39 ALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTD 98
Query: 91 EFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQ 150
EFL WN FD I ++S+P +IW PDI+INEFVD+ + P++PYVY+ G ++NYKP+Q
Sbjct: 99 EFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQ 158
Query: 151 VVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELL 210
VV+ACSL+ Y FPFDVQNCSLTF S LHT++D++++ R PE ++ D+ F+N EWELL
Sbjct: 159 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 218
Query: 211 SVSSTY-SILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRA 269
V + S+ +A+++F VV+RR PL YVVSLL+PSIFLM++D+ FYLPPN
Sbjct: 219 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 278
Query: 270 RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGH------------------------- 304
R+ FK ++L+GY+VF + +S+ +P + TPLIG
Sbjct: 279 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLAS 338
Query: 305 -------FFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP---------------FLCL 342
+F +CMA LV+SLA++I +V+ +H + +QP LCL
Sbjct: 339 ALGCTGVYFVVCMALLVISLAETIFIVRLVHKQD---LQQPVPAWLRHLVLERIAWLLCL 395
Query: 343 RGDTDADRPRVEPRAQRAVVTES-SLYGEHLAQPGTLKE--------------------- 380
R + + RP P +A T+ S G H + G ++
Sbjct: 396 REQSTSQRP---PATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLA 452
Query: 381 ---VWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWAL 437
+ +L SI +L+ +D+ + +WL + S D+LLF YL + Y+ITL LW++
Sbjct: 453 VCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSI 512
Query: 438 W 438
W
Sbjct: 513 W 513
>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
Length = 471
Score = 210 bits (534), Expect = 2e-54
Identities = 134/405 (33%), Positives = 208/405 (51%), Gaps = 16/405 (3%)
Query: 45 KEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIR 104
K RPV N + T V + + AILDV+ + +L + +W + VW++ F+SWN + I
Sbjct: 67 KPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGIT 126
Query: 105 EISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPF 164
++S+ +W PDI I E +D+++ P YV++ G I KP++V S C+L+ + FPF
Sbjct: 127 KMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPF 186
Query: 165 DVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFL-NDSEWELLSVSSTYSILQSSA 223
D QNC+LTF S L+TV+ + L + +I + L EWELL +S + L
Sbjct: 187 DQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGG 246
Query: 224 GGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTV 283
+ QI F V +RR P +YV++LL+PS FL+ +D SFYLP R+ FK ++L+GY V
Sbjct: 247 NLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNV 306
Query: 284 FRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP----F 339
F + MS+ +P S TPLIG +F +C++ +V SL ++I + LH P
Sbjct: 307 FLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHS 364
Query: 340 LCLR----GDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLK-EVWSQLQSISNYLQT 394
L L G P+ E + T E G + ++L S + +
Sbjct: 365 LLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRA 424
Query: 395 QDQTDQQEAE----WLVLLSRFDRLLFQSYLFMLGIYTITLCSLW 435
Q + + Q+ WL D +LF+ YL + IT+ LW
Sbjct: 425 QREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLW 469
>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
Length = 447
Score = 199 bits (506), Expect = 4e-51
Identities = 102/285 (35%), Positives = 167/285 (58%), Gaps = 3/285 (1%)
Query: 45 KEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIR 104
K RP N++ T V + + AIL VDA+ Q+L + +W VW++ F++WN I
Sbjct: 52 KAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGIN 111
Query: 105 EISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPF 164
++++ +W PDI I E +D+++ P Y++S G I+ KP++V S C+L+ + FPF
Sbjct: 112 KLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPF 171
Query: 165 DVQNCSLTFKSILHTVEDVDLAFLRSPEDI-QHDKKAFLNDSEWELLSVSSTYSILQSSA 223
D QNC+ TF S L+TV+ + L + +I +K EWELL ++ +
Sbjct: 172 DQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGN 231
Query: 224 GGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTV 283
+ QI F V +RR P +Y+++LL+PS FL+ +D SFYLP R FK ++L+GY V
Sbjct: 232 NLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNV 291
Query: 284 FRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328
F + M++ +P S TPLI +F +C++ +V+SL +++ + LH
Sbjct: 292 FLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLH 334
>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
Length = 468
Score = 172 bits (437), Expect = 4e-43
Identities = 109/402 (27%), Positives = 185/402 (46%), Gaps = 26/402 (6%)
Query: 35 LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94
L K L Q Y + VRPV + + L + ++DVD +NQ++ T+VW ++ W D L
Sbjct: 50 LLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLR 109
Query: 95 WNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSA 154
WN + I+ I +P ++W PDI++ + D + +GT+ P S+
Sbjct: 110 WNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSS 169
Query: 155 CSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSS 214
C+++ FPFD+QNCS+ F S + VD+ ED DK+ F ++ EWE++S +
Sbjct: 170 CTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL----EDQDVDKRDFFDNGEWEIVSATG 225
Query: 215 TYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFK 274
+ S + + ++ V++R PL Y + L+IP I L + + FYLP N +I
Sbjct: 226 SKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLC 285
Query: 275 TSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGG 334
TSVLV TVF + + +P S PLIG + M F+ LS+ ++ + H
Sbjct: 286 TSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTH 345
Query: 335 QEQ-------------PFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEV 381
LC+R D + E TES + TL+
Sbjct: 346 NAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEE-------TESG--SGPKSSRNTLEAA 396
Query: 382 WSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFM 423
++ I+ ++ ++ + +W + DR+ ++LF+
Sbjct: 397 LDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFV 438
>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
[Homo sapiens]
Length = 458
Score = 171 bits (434), Expect = 9e-43
Identities = 106/330 (32%), Positives = 168/330 (50%), Gaps = 15/330 (4%)
Query: 6 MAPLWACILVAAGILATDTH------HPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTV 59
M P + +L+ GI ++ T +D+ L HL Q Y K VRPV + V
Sbjct: 1 MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHL----FQGYQKWVRPVLHSNDTIKV 56
Query: 60 YLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDII 119
Y L + ++DVD +NQ++ T+VW ++ W D L WN + I I +P ++W PDI+
Sbjct: 57 YFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIV 116
Query: 120 INEFVDIERYPDL-PYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILH 178
+ E D L V V S+GT+ P S+C+++ FPFD QNCS+ F S +
Sbjct: 117 LFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTY 176
Query: 179 TVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRH 238
VDL + E++ D+K F ++ EWE+L+ + + I ++ V+RR
Sbjct: 177 DGTMVDLILIN--ENV--DRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRL 232
Query: 239 PLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGS 298
PL Y + L+IP + L + + FYLP + ++ TSVLV TVF + + +P S
Sbjct: 233 PLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKV 292
Query: 299 TPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328
PLIG + M F+ LS+ ++ ++ H
Sbjct: 293 IPLIGEYLLFIMIFVTLSIIVTVFVINVHH 322
>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
sapiens]
Length = 502
Score = 162 bits (411), Expect = 4e-40
Identities = 97/306 (31%), Positives = 161/306 (52%), Gaps = 13/306 (4%)
Query: 35 LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94
L K+L++ Y+ RPV N ++ TVY L + I+DVD +NQ+L T++W Q W D +L
Sbjct: 29 LYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQ 88
Query: 95 WNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPY---VYVNSSGTIENYKPIQV 151
WN S + ++ + P IW PDI++ D ER+ D + V VNSSG + P
Sbjct: 89 WNVSEYPGVKTVRFPDGQIWKPDILLYNSAD-ERF-DATFHTNVLVNSSGHCQYLPPGIF 146
Query: 152 VSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLS 211
S+C ++ FPFDVQ+C L F S + +DL + D ++ + EW+L+
Sbjct: 147 KSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEA------DISGYIPNGEWDLVG 200
Query: 212 VSSTYS--ILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRA 269
+ S + + + F V MRR L Y ++LLIP + + + L F LP +
Sbjct: 201 IPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGE 260
Query: 270 RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHD 329
+I +VL+ TVF + ++ +P + S PLI +F M + LS+ +++++++ H
Sbjct: 261 KISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHH 320
Query: 330 EQRGGQ 335
+ GG+
Sbjct: 321 DPDGGK 326
>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
(neuronal) [Homo sapiens]
Length = 529
Score = 159 bits (403), Expect = 4e-39
Identities = 89/297 (29%), Positives = 153/297 (51%), Gaps = 7/297 (2%)
Query: 35 LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94
L K L + Y++ RPV N + V L + ++DVD +NQ++ T+VW ++ W+D L
Sbjct: 62 LFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLR 121
Query: 95 WNSSMFDEIREISLPLSAIWAPDIIINEFVDIE-RYPDLPYVYVNSSGTIENYKPIQVVS 153
WN + F I + +P IW PDI++ D E + ++ S+GT+ P S
Sbjct: 122 WNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKS 181
Query: 154 ACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVS 213
+CS++ FPFD QNC + F S + +DL + D+ K + EW +++ +
Sbjct: 182 SCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDL----KDYWESGEWAIVNAT 237
Query: 214 STYSI--LQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARI 271
TY+ A + + + V+RR PL Y ++L+IP + + + + FYLP +C +I
Sbjct: 238 GTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKI 297
Query: 272 VFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328
SVL+ TVF + ++ +P + PLIG + M F+ LS+ ++ ++ H
Sbjct: 298 TLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHH 354
>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
precursor [Homo sapiens]
Length = 627
Score = 159 bits (402), Expect = 5e-39
Identities = 94/324 (29%), Positives = 163/324 (50%), Gaps = 8/324 (2%)
Query: 13 ILVAAGILATDTH-HPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDV 71
+L+ G+L +H + A L K+L Y+K RPV N + V L + ++DV
Sbjct: 17 LLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDV 76
Query: 72 DAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIE-RYP 130
D +NQ++ T+VW ++ W+D L W+ + ++ + I +P IW PDI++ D +
Sbjct: 77 DEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVT 136
Query: 131 DLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRS 190
L ++ G ++ P S+CS++ FPFD QNC++ F S + +DL + S
Sbjct: 137 HLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHS 196
Query: 191 PEDIQHDKKAFLNDSEWELLSVSSTYSI--LQSSAGGFAQIQFNVVMRRHPLVYVVSLLI 248
+ D+ F EW ++ TY+ + A + I + V+RR PL Y ++L+I
Sbjct: 197 ----RVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLII 252
Query: 249 PSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTI 308
P + + + + FYLP C +I SVL+ TVF + ++ +P + PLIG +
Sbjct: 253 PCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLF 312
Query: 309 CMAFLVLSLAKSIVLVKFLHDEQR 332
M F+ LS+ ++ ++ H R
Sbjct: 313 TMIFVTLSIVITVFVLNVHHRSPR 336
>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
Length = 494
Score = 158 bits (399), Expect = 1e-38
Identities = 91/321 (28%), Positives = 164/321 (51%), Gaps = 16/321 (4%)
Query: 9 LWACILVA--AGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVH 66
LW C+ G + T + L+H +L Y++ +RPV N + TV+ ++ +
Sbjct: 16 LWLCVFTPFFKGCVGCAT----EERLFH---KLFSHYNQFIRPVENVSDPVTVHFEVAIT 68
Query: 67 AILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII-NEFVD 125
+ +VD NQI++T++W + +WND L W+ +D I + +P IW PDI++ N V
Sbjct: 69 QLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVG 128
Query: 126 IERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDL 185
+ + +G I P S+C ++ FPFD QNCSL F S + ++DL
Sbjct: 129 DFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL 188
Query: 186 AFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGG--FAQIQFNVVMRRHPLVYV 243
+ S D+ F +SEWE++ S ++ + + I ++ +RR P+ Y
Sbjct: 189 LIIGSKVDMND----FWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYT 244
Query: 244 VSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIG 303
++L+IP +F+ + + FYLP +C ++ SVL+ TVF + ++ +P + PL+G
Sbjct: 245 INLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVG 304
Query: 304 HFFTICMAFLVLSLAKSIVLV 324
+ M F+ LS+ ++ ++
Sbjct: 305 EYLLFTMIFVTLSIVVTVFVL 325
>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
Length = 498
Score = 148 bits (374), Expect = 8e-36
Identities = 81/291 (27%), Positives = 151/291 (51%), Gaps = 12/291 (4%)
Query: 42 KYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFD 101
+Y+ +RP + ++ ++ L L + ++ V+ QI+ T+VW ++ W D L+WNSS ++
Sbjct: 39 RYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNSSRYE 98
Query: 102 EIREISLPLSAIWAPDIIINEFVD----IERYPDLPYVYVNSSGTIENYKPIQVVSACSL 157
+ + +P IW PDI++ D + Y +L V S+G++ P SAC +
Sbjct: 99 GVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNL---IVRSNGSVLWLPPAIYKSACKI 155
Query: 158 ETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYS 217
E FPFD QNC+L F+S + ++D+ L +P D F EW+++++ +
Sbjct: 156 EVKYFPFDQQNCTLKFRSWTYDHTEIDMV-LMTPTASMDD---FTPSGEWDIVALPGRRT 211
Query: 218 ILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSV 277
+ + + ++ +++R PL Y ++L+IP + L+ + FYLP +C ++ SV
Sbjct: 212 V-NPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCISV 270
Query: 278 LVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328
L+ T F + +S VP + PLIG + M + S+ S+ ++ H
Sbjct: 271 LLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHH 321
>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
precursor [Homo sapiens]
Length = 502
Score = 147 bits (371), Expect = 2e-35
Identities = 85/315 (26%), Positives = 154/315 (48%), Gaps = 11/315 (3%)
Query: 15 VAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAE 74
+ +G+ TDT ++ + HL +Y+K +RP N ++ TV L + + ++ V
Sbjct: 19 LCSGVWGTDT---EERLVEHLLDP--SRYNKLIRPATNGSELVTVQLMVSLAQLISVHER 73
Query: 75 NQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVD-IERYPDLP 133
QI+ T+VW + W D L+W FD ++++ LP IW PD+++ D +
Sbjct: 74 EQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYS 133
Query: 134 YVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPED 193
V+ G+I P SAC +E FPFD QNC++ F+S + ++DL
Sbjct: 134 NAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVAS 193
Query: 194 IQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFL 253
+ F EW+++++ + + I ++ ++RR PL Y ++L+IP + +
Sbjct: 194 LDD----FTPSGEWDIVALPGRRN-ENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLI 248
Query: 254 MLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFL 313
+ + FYLP +C ++ SVL+ TVF + +S VP + PL+G + M +
Sbjct: 249 TSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLV 308
Query: 314 VLSLAKSIVLVKFLH 328
S+ S+ ++ H
Sbjct: 309 TFSIVTSVCVLNVHH 323
>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
Length = 505
Score = 147 bits (370), Expect = 2e-35
Identities = 79/297 (26%), Positives = 154/297 (51%), Gaps = 7/297 (2%)
Query: 31 ALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWND 90
A + L ++L + Y++ +RPV N + ++ ++ + ++ VD NQI++T++W +++WND
Sbjct: 34 AEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWND 93
Query: 91 EFLSWNSSMFDEIREISLPLSAIWAPDIII-NEFVDIERYPDLPYVYVNSSGTIENYKPI 149
L WN S + + +P IW PDI++ N V + D + +G + P
Sbjct: 94 YKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPA 153
Query: 150 QVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWEL 209
S+C ++ FPFD QNC++ F S + +DL + S ++ K + EW +
Sbjct: 154 IFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNL----KDYWESGEWAI 209
Query: 210 LSVSSTYSILQSSAGG--FAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNC 267
+ ++ + + I +++ +RR PL Y ++L+IP + + + + FYLP +C
Sbjct: 210 IKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDC 269
Query: 268 RARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLV 324
++ SVL+ TVF + ++ +P + PLIG + M F+ LS+ ++ ++
Sbjct: 270 GEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL 326
>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
[Homo sapiens]
Length = 479
Score = 144 bits (364), Expect = 1e-34
Identities = 83/293 (28%), Positives = 149/293 (50%), Gaps = 8/293 (2%)
Query: 35 LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94
L L + Y +RPV + K V L + + I D+D NQIL +W +++W+D +L+
Sbjct: 34 LFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLT 93
Query: 95 WNSSMFDEIREISLPLSAIWAPDIII-NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVS 153
W+ +D + I +P +W PDI++ N+ D P V + G I P S
Sbjct: 94 WDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKS 153
Query: 154 ACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVS 213
+C ++ FPFD Q C+LTF S + VD+ D+ F+ D EWE+ +
Sbjct: 154 SCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSD----FIEDVEWEVHGMP 209
Query: 214 STYSILQ--SSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARI 271
+ +++ + + + F ++++R Y+V+LLIP + + + SFYLP ++
Sbjct: 210 AVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKV 269
Query: 272 VFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLV 324
++L+ TVF++ ++ +P S + PLIG ++ MA + S A +I+++
Sbjct: 270 SLGVTILLAMTVFQLMVAEIMPAS-ENVPLIGKYYIATMALITASTALTIMVM 321
>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
sapiens]
Length = 450
Score = 137 bits (344), Expect = 3e-32
Identities = 78/293 (26%), Positives = 145/293 (49%), Gaps = 8/293 (2%)
Query: 35 LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94
L + L Y +RPV + + V L++ + I+D+D NQ+L +W ++ W D +L
Sbjct: 33 LFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLR 92
Query: 95 WNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDL-PYVYVNSSGTIENYKPIQVVS 153
W+ + + + I +P S +W PDI++ D + V + G + P S
Sbjct: 93 WDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRS 152
Query: 154 ACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVS 213
+C ++ AFPFD Q+C LTF S H +D+ P F+ + EW +L +
Sbjct: 153 SCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDV----RPRGAAASLADFVENVEWRVLGMP 208
Query: 214 STYSILQ--SSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARI 271
+ +L + + + F +++RR YV +LL+P + + L+ +F+LP + ++
Sbjct: 209 ARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKV 268
Query: 272 VFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLV 324
+VL+ TVF++ ++ +P S PLIG ++ M + S A +I+++
Sbjct: 269 SLGVTVLLALTVFQLLLAESMP-PAESVPLIGKYYMATMTMVTFSTALTILIM 320
>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
precursor [Homo sapiens]
Length = 517
Score = 129 bits (324), Expect = 5e-30
Identities = 82/326 (25%), Positives = 159/326 (48%), Gaps = 18/326 (5%)
Query: 13 ILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVD 72
+L A + + + ++ + HL ++ + Y+KE+RPV + ++ V L L + ++ +
Sbjct: 10 LLAALAVCGSWGLNEEERLIRHLFQE--KGYNKELRPVAHKEESVDVALALTLSNLISLK 67
Query: 73 AENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDL 132
+ L T+VW + W D L WN+ F I + LP +W P+I++ D +
Sbjct: 68 EVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSF--QI 125
Query: 133 PY---VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLR 189
Y V V G + P S+C + FPFD QNCSL F S+ +T +++ L+ +
Sbjct: 126 SYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQ 185
Query: 190 SPED--------IQHDKKAFLNDSEWELLSVSSTYSI---LQSSAGGFAQIQFNVVMRRH 238
++ I D + F + EWE++ + ++ + I F +++RR
Sbjct: 186 DAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRK 245
Query: 239 PLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGS 298
PL Y++++L+P + + + FYLP + + SVL+ +VF + +S ++P + +
Sbjct: 246 PLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMA 305
Query: 299 TPLIGHFFTICMAFLVLSLAKSIVLV 324
PLIG F M + + + ++++
Sbjct: 306 IPLIGKFLLFGMVLVTMVVVICVIVL 331
>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
precursor [Homo sapiens]
Length = 457
Score = 128 bits (322), Expect = 9e-30
Identities = 86/321 (26%), Positives = 152/321 (47%), Gaps = 18/321 (5%)
Query: 14 LVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDA 73
L +AG++ H + L +L + Y VRPV + + V + L + +++VD
Sbjct: 12 LCSAGLVLGSEHETR------LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDE 65
Query: 74 ENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIE-RYPDL 132
NQI+ T+V ++ W D L WN + +++I +P IW PD+++ D +
Sbjct: 66 VNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF 125
Query: 133 PYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPE 192
V + +G I P S C + FPFD QNCS+ + + V + +PE
Sbjct: 126 TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAI----NPE 181
Query: 193 DIQHDKKAFLNDSEWELLSV-----SSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLL 247
Q D F+ EW + S TYS + + I ++ VM+R PL ++V+++
Sbjct: 182 SDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTP--YLDITYHFVMQRLPLYFIVNVI 239
Query: 248 IPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFT 307
IP + + FYLP + ++ SVL+ TVF + + +P + + PLIG +
Sbjct: 240 IPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYML 299
Query: 308 ICMAFLVLSLAKSIVLVKFLH 328
M F++ S+ +++++ H
Sbjct: 300 FTMVFVIASIIITVIVINTHH 320
>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
precursor [Homo sapiens]
Length = 493
Score = 125 bits (313), Expect = 1e-28
Identities = 80/327 (24%), Positives = 155/327 (47%), Gaps = 23/327 (7%)
Query: 13 ILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVD 72
+L+ G+L ++ LYH L Y RPV T+ L + + ++ ++
Sbjct: 8 VLLLLGLLGRGVGKNEELRLYH---HLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLN 64
Query: 73 AENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDL 132
+ + L TSVW W D L+++ F I + +P +W P+I++ +D + +
Sbjct: 65 EKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQF--GV 122
Query: 133 PY---VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFL- 188
Y V V G++ P S C++E FPFD QNCSL F+S + E+V+ F
Sbjct: 123 AYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAV 182
Query: 189 ----RSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGF------AQIQFNVVMRRH 238
++ I D +A+ + EW ++ +++ GG + +++++RR
Sbjct: 183 DNDGKTINKIDIDTEAYTENGEW---AIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRK 239
Query: 239 PLVYVVSLLIPSIFLMLVDLGSFYLPPNCRA-RIVFKTSVLVGYTVFRVNMSNQVPRSVG 297
PL YV+++++P + + + L +++LP + +VL+ TVF ++ ++P +
Sbjct: 240 PLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSL 299
Query: 298 STPLIGHFFTICMAFLVLSLAKSIVLV 324
S PL+G F M L + ++++
Sbjct: 300 SVPLLGRFLIFVMVVATLIVMNCVIVL 326
>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
precursor [Homo sapiens]
Length = 501
Score = 124 bits (311), Expect = 2e-28
Identities = 78/308 (25%), Positives = 151/308 (49%), Gaps = 17/308 (5%)
Query: 35 LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94
L ++L Y VRP V + L + ++ ++ +++ + T V+ W D LS
Sbjct: 30 LREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLS 89
Query: 95 WNSSMFDEIREISLPLSAIWAPDIII--NEFVDIERYPDLPYVYVNSSGTIENYKPIQVV 152
W+ + D I + + ++W PD+++ N + + D+ V V+S G++ P
Sbjct: 90 WDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVV-VSSDGSVRWQPPGIYR 148
Query: 153 SACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDK-----KAFLNDSEW 207
S+CS++ FPFD QNC++ F S + +V L P+ H + F+ + +W
Sbjct: 149 SSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQW 208
Query: 208 ELLSVSSTYSILQSSA-------GGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGS 260
E++ S ++Q G ++ F +++RR PL Y+V+++ P I + L+ +
Sbjct: 209 EIIHKPSR--LIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFV 266
Query: 261 FYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKS 320
FYLPP+ ++ L+ TVF + ++++VP + S P+I + M + S+ S
Sbjct: 267 FYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILS 326
Query: 321 IVLVKFLH 328
+V++ H
Sbjct: 327 VVVLNLHH 334
Score = 30.8 bits (68), Expect = 2.6
Identities = 14/54 (25%), Positives = 27/54 (50%)
Query: 378 LKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITL 431
L+EV S + I+ LQ Q+ D + +W + DRL +++ + T+ +
Sbjct: 433 LREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVI 486
>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
precursor [Homo sapiens]
Length = 517
Score = 122 bits (305), Expect = 8e-28
Identities = 79/301 (26%), Positives = 144/301 (47%), Gaps = 13/301 (4%)
Query: 35 LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94
L L+Q Y +RP + V L L + ++ ++ + L T+VW + W D L
Sbjct: 29 LLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLR 88
Query: 95 WNSSMFDEIREISLPLSAIWAPDIIINEFVD-IERYPDLPYVYVNSSGTIENYKPIQVVS 153
W+ ++ + + +P + +W PDI++ VD + V V+ G I P S
Sbjct: 89 WDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRS 148
Query: 154 ACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQH------DKKAFLNDSEW 207
ACS+ FPFD QNCSL F+S ++ ++DL S ED Q D +AF + EW
Sbjct: 149 ACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL--SQEDGQTIEWIFIDPEAFTENGEW 206
Query: 208 ELLSVSSTYSI---LQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLP 264
+ + + + G ++ F ++++R PL YV++++ P + + V + +LP
Sbjct: 207 AIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLP 266
Query: 265 PNCRA-RIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVL 323
+ +VL+ TVF ++ +VP + + PLI + T + +L + ++V+
Sbjct: 267 AKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVV 326
Query: 324 V 324
+
Sbjct: 327 L 327
>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
precursor [Homo sapiens]
Length = 482
Score = 115 bits (289), Expect = 6e-26
Identities = 87/346 (25%), Positives = 152/346 (43%), Gaps = 43/346 (12%)
Query: 14 LVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDA 73
L +AG++ H + L +L + Y VRPV + + V + L + +++VD
Sbjct: 12 LCSAGLVLGSEHETR------LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDE 65
Query: 74 ENQILKTSVWYQ-------------------------EVWNDEFLSWNSSMFDEIREISL 108
NQI+ T+V + E W D L WN + +++I +
Sbjct: 66 VNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHI 125
Query: 109 PLSAIWAPDIIINEFVDIE-RYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQ 167
P IW PD+++ D + V + +G I P S C + FPFD Q
Sbjct: 126 PSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQ 185
Query: 168 NCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSV-----SSTYSILQSS 222
NCS+ + + V + +PE Q D F+ EW + S TYS +
Sbjct: 186 NCSMKLGTWTYDGSVVAI----NPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDT 241
Query: 223 AGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYT 282
+ I ++ VM+R PL ++V+++IP + + FYLP + ++ SVL+ T
Sbjct: 242 P--YLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLT 299
Query: 283 VFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328
VF + + +P + + PLIG + M F++ S+ +++++ H
Sbjct: 300 VFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH 345
>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
Length = 412
Score = 96.7 bits (239), Expect = 4e-20
Identities = 79/349 (22%), Positives = 150/349 (42%), Gaps = 25/349 (7%)
Query: 39 LLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSS 98
L +K + ++ N + V + +FV + +VD + + + + W D L+WN+S
Sbjct: 42 LSKKVQESIQIPNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTS 101
Query: 99 MFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLE 158
I+LP ++W P + I E + ++ P V+ G ++ + + C+ E
Sbjct: 102 AHPR-HAITLPWESLWTPRLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFE 160
Query: 159 TYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSI 218
FP D NCSL+F ++ +T +++ + +N E++SV Y +
Sbjct: 161 LLHFPRDHSNCSLSFYALSNTAMELEF------------QAHVVN----EIVSVKREYVV 204
Query: 219 LQSSAGGFAQ-----IQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVF 273
Q Q + ++ L +++LL+P+ L+L D+ LP RI +
Sbjct: 205 YDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGY 264
Query: 274 KTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRG 333
K ++L+ Y V ++ +P S PL+ ++FTI + L LS ++++L L G
Sbjct: 265 KVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLG 324
Query: 334 GQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVW 382
+ P RG+ R P A + G + P T ++
Sbjct: 325 AKSGPSPAPRGE---QREHGNPGPHPAEEPSRGVKGSQRSWPETADRIF 370
>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
Length = 412
Score = 95.5 bits (236), Expect = 8e-20
Identities = 59/203 (29%), Positives = 102/203 (50%), Gaps = 8/203 (3%)
Query: 135 VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDI 194
V VNSSG + P S+C ++ FPFDVQ+C L F S + +DL +
Sbjct: 40 VLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEA---- 95
Query: 195 QHDKKAFLNDSEWELLSVSSTYS--ILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIF 252
D ++ + EW+L+ + S + + + F V MRR L Y ++LLIP +
Sbjct: 96 --DISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVL 153
Query: 253 LMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAF 312
+ + L F LP + +I +VL+ TVF + ++ +P + S PLI +F M
Sbjct: 154 ISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMII 213
Query: 313 LVLSLAKSIVLVKFLHDEQRGGQ 335
+ LS+ +++++++ H + GG+
Sbjct: 214 VGLSVVVTVIVLQYHHHDPDGGK 236
>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 82.4 bits (202), Expect = 7e-16
Identities = 76/321 (23%), Positives = 137/321 (42%), Gaps = 15/321 (4%)
Query: 9 LWACILVAAGILATDTHHP--QD------SALYHLSKQLLQKYHKEVRPVYNWTKATTVY 60
LWA IL+ + + P QD + + +LL Y +RP + T V
Sbjct: 11 LWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLG-ERVTEVK 69
Query: 61 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII 120
D+FV + V + V++++ W DE L + M +R +L S IW PD
Sbjct: 70 TDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPM-TVLRLNNLMASKIWTPDTFF 128
Query: 121 -NEFVDIERYPDLP--YVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSIL 177
N + +P + + GT+ + V + C + FP D C L F S
Sbjct: 129 HNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYA 188
Query: 178 HTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRR 237
+T +V + R P + ++++LL + I+QSS G + + + ++R
Sbjct: 189 YTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKR 248
Query: 238 HPLVYVVSLLIPSIFLMLVDLGSFYL-PPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSV 296
+V+ +P I +++ SF+L + AR VF + ++ T ++ N +P+
Sbjct: 249 KIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 308
Query: 297 GSTPLIGHFFTICMAFLVLSL 317
+T + F +C AF+ +L
Sbjct: 309 YATAM-DWFIAVCYAFVFSAL 328
>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 82.4 bits (202), Expect = 7e-16
Identities = 76/321 (23%), Positives = 137/321 (42%), Gaps = 15/321 (4%)
Query: 9 LWACILVAAGILATDTHHP--QD------SALYHLSKQLLQKYHKEVRPVYNWTKATTVY 60
LWA IL+ + + P QD + + +LL Y +RP + T V
Sbjct: 11 LWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLG-ERVTEVK 69
Query: 61 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII 120
D+FV + V + V++++ W DE L + M +R +L S IW PD
Sbjct: 70 TDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPM-TVLRLNNLMASKIWTPDTFF 128
Query: 121 -NEFVDIERYPDLP--YVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSIL 177
N + +P + + GT+ + V + C + FP D C L F S
Sbjct: 129 HNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYA 188
Query: 178 HTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRR 237
+T +V + R P + ++++LL + I+QSS G + + + ++R
Sbjct: 189 YTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKR 248
Query: 238 HPLVYVVSLLIPSIFLMLVDLGSFYL-PPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSV 296
+V+ +P I +++ SF+L + AR VF + ++ T ++ N +P+
Sbjct: 249 KIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 308
Query: 297 GSTPLIGHFFTICMAFLVLSL 317
+T + F +C AF+ +L
Sbjct: 309 YATAM-DWFIAVCYAFVFSAL 328
>gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 82.4 bits (202), Expect = 7e-16
Identities = 76/321 (23%), Positives = 137/321 (42%), Gaps = 15/321 (4%)
Query: 9 LWACILVAAGILATDTHHP--QD------SALYHLSKQLLQKYHKEVRPVYNWTKATTVY 60
LWA IL+ + + P QD + + +LL Y +RP + T V
Sbjct: 11 LWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLG-ERVTEVK 69
Query: 61 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII 120
D+FV + V + V++++ W DE L + M +R +L S IW PD
Sbjct: 70 TDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPM-TVLRLNNLMASKIWTPDTFF 128
Query: 121 -NEFVDIERYPDLP--YVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSIL 177
N + +P + + GT+ + V + C + FP D C L F S
Sbjct: 129 HNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYA 188
Query: 178 HTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRR 237
+T +V + R P + ++++LL + I+QSS G + + + ++R
Sbjct: 189 YTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKR 248
Query: 238 HPLVYVVSLLIPSIFLMLVDLGSFYL-PPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSV 296
+V+ +P I +++ SF+L + AR VF + ++ T ++ N +P+
Sbjct: 249 KIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 308
Query: 297 GSTPLIGHFFTICMAFLVLSL 317
+T + F +C AF+ +L
Sbjct: 309 YATAM-DWFIAVCYAFVFSAL 328
>gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 82.4 bits (202), Expect = 7e-16
Identities = 76/321 (23%), Positives = 137/321 (42%), Gaps = 15/321 (4%)
Query: 9 LWACILVAAGILATDTHHP--QD------SALYHLSKQLLQKYHKEVRPVYNWTKATTVY 60
LWA IL+ + + P QD + + +LL Y +RP + T V
Sbjct: 11 LWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLG-ERVTEVK 69
Query: 61 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII 120
D+FV + V + V++++ W DE L + M +R +L S IW PD
Sbjct: 70 TDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPM-TVLRLNNLMASKIWTPDTFF 128
Query: 121 -NEFVDIERYPDLP--YVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSIL 177
N + +P + + GT+ + V + C + FP D C L F S
Sbjct: 129 HNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYA 188
Query: 178 HTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRR 237
+T +V + R P + ++++LL + I+QSS G + + + ++R
Sbjct: 189 YTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKR 248
Query: 238 HPLVYVVSLLIPSIFLMLVDLGSFYL-PPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSV 296
+V+ +P I +++ SF+L + AR VF + ++ T ++ N +P+
Sbjct: 249 KIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 308
Query: 297 GSTPLIGHFFTICMAFLVLSL 317
+T + F +C AF+ +L
Sbjct: 309 YATAM-DWFIAVCYAFVFSAL 328
>gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 82.4 bits (202), Expect = 7e-16
Identities = 76/321 (23%), Positives = 137/321 (42%), Gaps = 15/321 (4%)
Query: 9 LWACILVAAGILATDTHHP--QD------SALYHLSKQLLQKYHKEVRPVYNWTKATTVY 60
LWA IL+ + + P QD + + +LL Y +RP + T V
Sbjct: 11 LWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLG-ERVTEVK 69
Query: 61 LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII 120
D+FV + V + V++++ W DE L + M +R +L S IW PD
Sbjct: 70 TDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPM-TVLRLNNLMASKIWTPDTFF 128
Query: 121 -NEFVDIERYPDLP--YVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSIL 177
N + +P + + GT+ + V + C + FP D C L F S
Sbjct: 129 HNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYA 188
Query: 178 HTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRR 237
+T +V + R P + ++++LL + I+QSS G + + + ++R
Sbjct: 189 YTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKR 248
Query: 238 HPLVYVVSLLIPSIFLMLVDLGSFYL-PPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSV 296
+V+ +P I +++ SF+L + AR VF + ++ T ++ N +P+
Sbjct: 249 KIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 308
Query: 297 GSTPLIGHFFTICMAFLVLSL 317
+T + F +C AF+ +L
Sbjct: 309 YATAM-DWFIAVCYAFVFSAL 328
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,079,442
Number of Sequences: 37866
Number of extensions: 662630
Number of successful extensions: 1737
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1549
Number of HSP's gapped (non-prelim): 89
length of query: 441
length of database: 18,247,518
effective HSP length: 105
effective length of query: 336
effective length of database: 14,271,588
effective search space: 4795253568
effective search space used: 4795253568
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.