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Search of human proteins with 50511340
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50511340 shootin1 isoform b [Homo sapiens]
(456 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50511340 shootin1 isoform b [Homo sapiens] 885 0.0
gi|187761324 shootin1 isoform a [Homo sapiens] 880 0.0
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 83 6e-16
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 80 5e-15
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 78 1e-14
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 78 2e-14
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 78 2e-14
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 76 6e-14
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 76 7e-14
gi|71061468 centromere protein E [Homo sapiens] 75 1e-13
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 74 2e-13
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 74 2e-13
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 74 2e-13
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 74 3e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 74 3e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 74 3e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 74 3e-13
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 73 6e-13
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 72 8e-13
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 72 8e-13
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 72 1e-12
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 71 2e-12
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 71 2e-12
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 70 4e-12
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 70 4e-12
gi|75677376 coiled-coil domain containing 62 isoform b [Homo sap... 70 5e-12
gi|30348972 coiled-coil domain containing 62 isoform a [Homo sap... 70 5e-12
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 69 7e-12
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 69 7e-12
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 69 9e-12
>gi|50511340 shootin1 isoform b [Homo sapiens]
Length = 456
Score = 885 bits (2286), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH
Sbjct: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID
Sbjct: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN
Sbjct: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
Query: 181 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 240
KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI
Sbjct: 181 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 240
Query: 241 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH 300
EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH
Sbjct: 241 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH 300
Query: 301 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP 360
KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP
Sbjct: 301 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP 360
Query: 361 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG 420
PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG
Sbjct: 361 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG 420
Query: 421 VHLRPVNQTARPKTKPESSKGCESAVDELKGILASQ 456
VHLRPVNQTARPKTKPESSKGCESAVDELKGILASQ
Sbjct: 421 VHLRPVNQTARPKTKPESSKGCESAVDELKGILASQ 456
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 880 bits (2274), Expect = 0.0
Identities = 453/455 (99%), Positives = 454/455 (99%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH
Sbjct: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID
Sbjct: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN
Sbjct: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
Query: 181 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 240
KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI
Sbjct: 181 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 240
Query: 241 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH 300
EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH
Sbjct: 241 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH 300
Query: 301 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP 360
KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP
Sbjct: 301 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPP 360
Query: 361 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG 420
PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG
Sbjct: 361 PLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKG 420
Query: 421 VHLRPVNQTARPKTKPESSKGCESAVDELKGILAS 455
VHLRPVNQTARPKTKPESSKGCESAVDELKGIL +
Sbjct: 421 VHLRPVNQTARPKTKPESSKGCESAVDELKGILGT 455
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 82.8 bits (203), Expect = 6e-16
Identities = 92/381 (24%), Positives = 176/381 (46%), Gaps = 50/381 (13%)
Query: 6 EEKQLQLITSLKEQAIGEY-EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
E ++L+ + K+Q + E DL A ++ +E+C ++ E+ + + ++E ++ +E
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE----QLE 953
Query: 65 EVNFMQNHLEIEKTCRESAEALATKLNKENKTLK--RISMLYMAKLGPDVITE-EINIDD 121
E + L++EK + EA KL +E L+ + KL D I E N+ +
Sbjct: 954 EEESARQKLQLEKV---TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE 1010
Query: 122 EDSTTDTDGAAETCVSVQC----------QKQIKELRDQIVSVQEEKKILAIELENLKSK 171
E+ + + + +KQ +EL ++ + L+ ++ L+++
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ 1070
Query: 172 LVEVIEEVNKVKQEKTV----LNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDL 227
+ E+ ++ K ++E + E ++ L+K + + E+Q +LE E+
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE----SQISELQEDLESERAS 1126
Query: 228 RKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ-----------LLKALDENAKLTQ-Q 275
R KAE +++ E LK + L S+ Q+ L K L+E AK + Q
Sbjct: 1127 RNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 276 LEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKEL--ELKY-----QNSE 328
++E R +H Q V+EL EQLE K NL++ + LE ++ EL E+K +SE
Sbjct: 1187 IQEMRQKHSQAVEELAEQLEQTKRVKA--NLEKAKQTLENERGELANEVKVLLQGKGDSE 1244
Query: 329 EKARNLKHSVDELQKRVNQSE 349
K + ++ + ELQ + N+ E
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGE 1265
Score = 65.5 bits (158), Expect = 1e-10
Identities = 78/371 (21%), Positives = 165/371 (44%), Gaps = 35/371 (9%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERD---EAVKKLEEFQK-ISHMV 62
+K L+ ++ E+ + Y+ L + +++ D + + D ++ LE+ QK ++
Sbjct: 1391 QKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL 1450
Query: 63 IEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMA---KLGPDVITEEINI 119
EE + E R+ AEA A + KE K L L A K + + ++
Sbjct: 1451 AEEKTISAKYAEE----RDRAEAEARE--KETKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 120 DDEDSTTDTDGAAETCVSVQCQK------------QIKELRDQIVSVQEEKKILAIELEN 167
+ ED + D ++ ++ K Q++EL D++ + ++ K L + L+
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 168 LKSKLVEVIEEVNKVKQEKTV-LNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNL-ELEK 225
+K++ ++ ++ +EK L +V E LE + +AV ++++++L +LE
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 226 DL---RKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQ 282
+ K + +++ Q ++K L + +++L EN K + +E E IQ
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 283 HQQKVKELEE-----QLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHS 337
Q+++ E Q E + L EI N + L E+K+ LE + EE+ + +
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744
Query: 338 VDELQKRVNQS 348
+ + R+ ++
Sbjct: 1745 TELINDRLKKA 1755
Score = 60.5 bits (145), Expect = 3e-09
Identities = 68/342 (19%), Positives = 145/342 (42%), Gaps = 19/342 (5%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
E+ +L+L +L+ DL+ +++++EK ++ ++ E +LE+ +K M +
Sbjct: 1552 EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDST 125
++ L+ + +SA + K+ + L+ M +L + E I +
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE-EILAQAKE 1670
Query: 126 TDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQE 185
+ + +Q Q+++ Q+E+ LA E+ N K +EE +++
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730
Query: 186 KTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKL 245
L E+ E++ E N A + +++ +L LE+ +K E+ Q++ + +L
Sbjct: 1731 IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKEL 1790
Query: 246 KRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHN 305
K +K + + + + + K+ +LEEQL+NET KE
Sbjct: 1791 K----------------VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET--KERQA 1832
Query: 306 LKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ 347
+Q+ E+ K++ L+ + A K D+ R+ Q
Sbjct: 1833 ACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874
Score = 53.1 bits (126), Expect = 5e-07
Identities = 63/336 (18%), Positives = 147/336 (43%), Gaps = 16/336 (4%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
EK Q + + + + E + L ++ K K+ + E K E +++ + ++V
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275
Query: 67 NFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPD------VITEEINID 120
+Q L+ +++ ++KL K+ L+ L + + T+ ++
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQE--EKKILAIEL-ENLKSKLVEVIE 177
DE ++ E +KQI L Q+ +++ E + +E E +K KL + +E
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395
Query: 178 EVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQE 237
+++ +EK ++ + + L++ + L V+ + Q LEK +K + A+E
Sbjct: 1396 GLSQRHEEKVAAYDKLEKTKTRLQQ--ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE 1453
Query: 238 MFIEQNKLKRQSHLLLQSSIPDQQLL---KALDENAKLTQQLEEERIQHQQKVKELEEQL 294
I + + ++ + + L +AL+E + Q+ E ER+ Q + + +
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARALEE--AMEQKAELERLNKQFRTEMEDLMS 1511
Query: 295 ENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEK 330
+ + K +H L++ LE+ +E++ + + E++
Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547
Score = 52.0 bits (123), Expect = 1e-06
Identities = 68/367 (18%), Positives = 159/367 (43%), Gaps = 53/367 (14%)
Query: 1 MNSSDEEKQLQLI-------TSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLE 53
M + +E++LQ + K A+ + +L ++ + +E + R R++A K+
Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR 1135
Query: 54 EFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVI 113
+ EE+ ++ LE + + L +K +E LK+ L +
Sbjct: 1136 DLG-------EELEALKTELEDTLDSTAAQQELRSKREQEVNILKK-------TLEEEAK 1181
Query: 114 TEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLV 173
T E I E + E ++ K++K ++++ K+ L E L +++
Sbjct: 1182 THEAQI-QEMRQKHSQAVEELAEQLEQTKRVK------ANLEKAKQTLENERGELANEVK 1234
Query: 174 EVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAES 233
+++ + ++ + +++ E + + RV ++ ++QV L+ L +++S
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDS 1294
Query: 234 FAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLT-----QQLEEERIQHQQKVK 288
+ ++ + L+S + D Q L + KL+ +Q+E+E+ +++++
Sbjct: 1295 KSSKL--------TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE 1346
Query: 289 ELEEQLEN-----ETLHKEIHNLKQQ-------LELLEEDKKELELKYQNSEEKARNLKH 336
E EE N TLH ++ ++K++ LE EE K++L+ + ++
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA 1406
Query: 337 SVDELQK 343
+ D+L+K
Sbjct: 1407 AYDKLEK 1413
Score = 50.1 bits (118), Expect = 4e-06
Identities = 77/378 (20%), Positives = 156/378 (41%), Gaps = 48/378 (12%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
+K Q + L EQ + + + ++A +K K+ + R E VK L + + S ++V
Sbjct: 1192 QKHSQAVEELAEQ-LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKV 1250
Query: 67 NFMQNHLEIEKTCRESAEA-LATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDST 125
L+++ E LA K+ K L ++ L D + S
Sbjct: 1251 EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS------------DSKSSK 1298
Query: 126 TDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQE 185
D +A Q+ ++E Q +S+ + K + E + + +L E E + ++++
Sbjct: 1299 LTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQ 1358
Query: 186 KTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKL 245
L+++V + +K +E + V L E + ++ +LE ++ E A +E+ K
Sbjct: 1359 IATLHAQVADMKKKME--DSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKT 1416
Query: 246 KRQSHL--LLQSSIPDQQLLKALDENAKLTQQL-------------EEERIQHQQKVKE- 289
+ Q L LL +Q L++ K QL E +R + + + KE
Sbjct: 1417 RLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET 1476
Query: 290 ------------LEEQLENETLHKEIHNLKQQLELLEEDK----KELELKYQNSEEKARN 333
+E++ E E L+K+ + L ++D ELE + E++
Sbjct: 1477 KALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536
Query: 334 LKHSVDELQKRVNQSENS 351
+K ++EL+ + +E++
Sbjct: 1537 MKTQLEELEDELQATEDA 1554
Score = 39.3 bits (90), Expect = 0.007
Identities = 48/212 (22%), Positives = 98/212 (46%), Gaps = 28/212 (13%)
Query: 168 LKSKLVEVIEEVNKVKQEKTVLNSEVL----EQRKV--------LEKCNRVSMLAVEEYE 215
L K +E+ + ++ Q K + VL E+R + + C R LA + +
Sbjct: 742 LMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCR-GYLARKAFA 800
Query: 216 EMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQ 275
+ Q L K L++ ++ + + +L + LLQ S +++++ +E K+ ++
Sbjct: 801 KRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREK 860
Query: 276 --------LEEERIQHQQKVK--ELEEQLENET-LHKEIHNLKQQL----ELLEEDKKEL 320
E E +Q Q + +L+EQL+ ET L E L+ +L + LEE +L
Sbjct: 861 QLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDL 920
Query: 321 ELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
E + + EE+ ++L+ ++Q+ + + E +
Sbjct: 921 EARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 79.7 bits (195), Expect = 5e-15
Identities = 91/405 (22%), Positives = 181/405 (44%), Gaps = 78/405 (19%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQ-----------ERD---EAVK 50
D E+Q+ L+++ E DLR +NQ +++ +K+R+ ERD + ++
Sbjct: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQ 2088
Query: 51 KLEE-------FQKISHMVIEEVNFMQNHLEIEKT--CRE---SAEALATKLNKENKTLK 98
KLE+ FQ IS EV + NHL+ EKT C E S E L + + N+ ++
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLK-EKTDKCSELLLSKEQLQRDIQERNEEIE 2147
Query: 99 RISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQ---IKELRDQIVSVQ 155
++ + + + ++D + E + VQ Q + I +I +++
Sbjct: 2148 KLEFRVRE------LEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLE 2201
Query: 156 EEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYE 215
E+ + ELEN ++ ++ ++ K+E T E+ ++ K+ + LA++E +
Sbjct: 2202 EQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESD 2261
Query: 216 EMQV---------------NLELEKD-LRKKAESFAQEMFI--------EQNKLKRQSHL 251
M E+E D L ++ Q++ I E+N+L R
Sbjct: 2262 AMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLET 2321
Query: 252 LLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN---------ETLHKE 302
++ + DQ+ +K + EEE Q + +++L+++L N +L +E
Sbjct: 2322 QIECLMSDQECVK---------RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEE 2372
Query: 303 IHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ 347
+LK QL+++ +K LE + + + E+ +K+ + E ++NQ
Sbjct: 2373 ADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2417
Score = 62.8 bits (151), Expect = 6e-10
Identities = 89/394 (22%), Positives = 166/394 (42%), Gaps = 83/394 (21%)
Query: 8 KQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVN 67
+QLQ +L+ + A+ + K++ +Q+ +E LE++QK +++
Sbjct: 243 QQLQASETLRNST---HSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQIS 299
Query: 68 FMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEE---INIDDEDS 124
F+Q +++ + ++ K+ NK + + +L +I EE + + D+ +
Sbjct: 300 FLQEKIKVYEMEQDK------KVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLT 353
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSK----------LVE 174
T D K + EL++QIV +E K + +EL N K K L+
Sbjct: 354 TAD--------------KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399
Query: 175 VIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVE---------------------- 212
+EE+ K + + ++++ QR E ++ L E
Sbjct: 400 TVEELQKRNHKDSQFETDIV-QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA 458
Query: 213 EYEEMQVNL--ELEKDLRKKAESFAQEMFIE-QNKLKRQSHLLLQSSIPDQQLLK----- 264
+ EEM+ E+E LR + E I+ N + ++ LQ + ++ LK
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL 518
Query: 265 ALDENAKLTQQLEE---------ERIQHQQKVKELEEQLENETLHKE---IHNLKQQLEL 312
L+E L +QLE+ E+IQ ++ +E NE HK + +LK ++
Sbjct: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEA-HKSLSTVEDLKAEIVS 577
Query: 313 LEEDKKELELKYQNSEEKARNLKHSVDELQKRVN 346
E +KELELK+ E + N K ++ L+K N
Sbjct: 578 ASESRKELELKH---EAEVTNYKIKLEMLEKEKN 608
Score = 62.4 bits (150), Expect = 8e-10
Identities = 94/385 (24%), Positives = 178/385 (46%), Gaps = 41/385 (10%)
Query: 2 NSSDEEKQLQLITSLKEQAI--GEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQK-- 57
NS E+ + +L L+E+ + EDL E ++E+ + RQ E KL E K
Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL 565
Query: 58 --ISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKE------NKTLKRISMLYMAKLG 109
+ + E V+ ++ E+E + AE K+ E N L R++ A+L
Sbjct: 566 STVEDLKAEIVSASESRKELE--LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 110 PDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKEL--RDQIVSVQEEK----KILAI 163
+ ++E S D E ++++ K + + QI +Q E + +
Sbjct: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
Query: 164 ELENLKSKLVEVIEEVNKVKQ-EKTVLNSEVLEQR-KVLEKCNRVSMLAVEEYEEMQVNL 221
E +NL +K ++I E++K+K +++++NS+ E ++ E + +L EE E+ +
Sbjct: 684 EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQ 743
Query: 222 ELEKDLRKKAESFAQEMFIEQNKLKRQ-SHLLLQSSIPDQQLLKALDENAKL-TQQLEEE 279
E++ +L+ K E ++M ++N L+ + + L ++SI + K L++ K+ T +EE
Sbjct: 744 EVQ-ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK-KTLEDMLKIHTPVSQEE 801
Query: 280 RIQHQQKVKELEE----QLENETLHKEIHNLKQQLELLEED-----------KKELELKY 324
R+ +K + + E E L +E +LKQQ L E+ +K E+ Y
Sbjct: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
Query: 325 QNSEEKARNLKHSVDELQKRVNQSE 349
Q +E+ L D+L+ N+ E
Sbjct: 862 QELQEEYACLLKVKDDLEDSKNKQE 886
Score = 60.5 bits (145), Expect = 3e-09
Identities = 78/358 (21%), Positives = 166/358 (46%), Gaps = 65/358 (18%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
N + E Q++L+ + + +D ++ +K KE+ I +E+ ++LE+
Sbjct: 480 NITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLED------- 532
Query: 62 VIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDD 121
++EE++F + ++ R++ +KLN+ +K+L + L + +E+ +
Sbjct: 533 LVEELSFSREQIQ---RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKH 589
Query: 122 EDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLV-EVIEEVN 180
E T+ E +K+ + D++ QE ELE L+++L+ EE++
Sbjct: 590 EAEVTNYKIKLE-----MLEKEKNAVLDRMAESQEA------ELERLRTQLLFSHEEELS 638
Query: 181 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 240
K+K++ + E R +EK L + +++ L+ ++ +K E+ F
Sbjct: 639 KLKEDLEI------EHRINIEKLK--DNLGIHYKQQID---GLQNEMSQKIETM---QFE 684
Query: 241 EQNKLKRQSHLLLQ-SSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETL 299
+ N + +Q+ L+L+ S + D Q ++ ++T Q+ E L
Sbjct: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE--------------------L 724
Query: 300 HKEIHNLKQQLE---LLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ--SENSV 352
KEI L+Q+ + LE++ +EL+LK +E + +K ++LQ++ Q +ENS+
Sbjct: 725 QKEIEILRQEEKEKGTLEQEVQELQLK---TELLEKQMKEKENDLQEKFAQLEAENSI 779
Score = 56.6 bits (135), Expect = 5e-08
Identities = 57/229 (24%), Positives = 110/229 (48%), Gaps = 23/229 (10%)
Query: 133 ETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSE 192
E S++CQ+ ELR+++ ++ LA+EL SK VI+ EKT+ +
Sbjct: 1888 EATESLKCQE---ELRERLHEESRAREQLAVEL----SKAEGVIDGY---ADEKTLFERQ 1937
Query: 193 VLEQRKVLEKCNRVSMLA---VEEYEEMQVNLELEKDL--RKKAESFAQEMFIEQNKLKR 247
+ E+ ++++ + + A ++E E Q ++ E++L R+K A+ +EQ L+
Sbjct: 1938 IQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE 1997
Query: 248 QSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLK 307
L+ + Q K D+ K + LE + + + ELE++ E + +L+
Sbjct: 1998 TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELM-----DLR 2052
Query: 308 QQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPP 356
QQ + LE K+LE + +E+A + +H D Q+ + + E + P
Sbjct: 2053 QQNQALE---KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
Score = 55.8 bits (133), Expect = 8e-08
Identities = 86/381 (22%), Positives = 166/381 (43%), Gaps = 71/381 (18%)
Query: 3 SSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKE-KCDKIRQERDEAVKKLEEF------ 55
++ ++K+ Q +K Q +G E+L+ N K + + D +++ E +KLE+
Sbjct: 381 TNSKQKERQSSEEIK-QLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDE 439
Query: 56 ---QKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDV 112
Q+I M E + +E KT R E + N T+ + M +V
Sbjct: 440 MYGQQIVQMKQELIRQHMAQMEEMKT-RHKGEMENALRSYSNITVNEDQIKLM-----NV 493
Query: 113 ITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKL 172
E+NI +D+ + Q ++L++++ + EEK L +LE
Sbjct: 494 AINELNIKLQDTNS----------------QKEKLKEELGLILEEKCALQRQLE------ 531
Query: 173 VEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYE-EMQVNLELEKDLRKKA 231
+++EE++ +++ + EQ L + ++ S+ VE+ + E+ E K+L K
Sbjct: 532 -DLVEELSFSREQIQRARQTIAEQESKLNEAHK-SLSTVEDLKAEIVSASESRKELELKH 589
Query: 232 ESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ----------LLKALDENAKLTQQLEEER- 280
E+ I+ L+++ + +L Q+ L +E +KL + LE E
Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Query: 281 -----------IQHQQKVKELEEQLEN--ETLHKEIHNL--KQQLELLEEDK-KELELKY 324
I ++Q++ L+ ++ ET+ E NL KQ +LE K K+L+
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709
Query: 325 QNSEEKARNLKHSVDELQKRV 345
NS+ + L+ ++ELQK +
Sbjct: 710 VNSKSEEMTLQ--INELQKEI 728
Score = 54.7 bits (130), Expect = 2e-07
Identities = 82/350 (23%), Positives = 157/350 (44%), Gaps = 60/350 (17%)
Query: 25 EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAE 84
E L E K + D E+ ++++E I + +E+ N L+ E
Sbjct: 1911 EQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ-------ELE 1963
Query: 85 ALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQI 144
A ++ +E + L R A+ GP ++ +T+ + + VQCQ +
Sbjct: 1964 AEQQQIQEERELLSRQKEAMKAEAGPV---------EQQLLQETEKLMKEKLEVQCQAE- 2013
Query: 145 KELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNK----VKQEKTVLNSEVLEQRKVL 200
++RD + Q++ K L I++E S+ +E+ +E N ++Q+ L ++ + RK L
Sbjct: 2014 -KVRDDL---QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Query: 201 EK--CNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQ--NKLKRQSHLLLQSS 256
++ +R V + E ++ +L+ R + S Q +EQ N LK ++ +
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
Query: 257 IPDQQLLKALDENAKLTQQLE------------EERIQHQQKVK-------ELEEQLENE 297
+ +QL + + E + ++LE E+R +H V+ E++ Q E +
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDR-KHFGAVEAKPELSLEVQLQAERD 2188
Query: 298 TL---HKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKR 344
+ KEI NL++QLE + ++ELE N E+ + L H E+QK+
Sbjct: 2189 AIDRKEKEITNLEEQLE---QFREELE----NKNEEVQQL-HMQLEIQKK 2230
Score = 53.9 bits (128), Expect = 3e-07
Identities = 80/378 (21%), Positives = 170/378 (44%), Gaps = 57/378 (15%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKC-DKIRQERDEAVKKL--EEFQKISHMV 62
E + QL+ S +E+ EDL E++ EK D + + + L E QKI M
Sbjct: 623 ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQ 682
Query: 63 IEEVNFM--QNHLEIE-KTCRESAEALATKLNKE-----NKTLKRISMLYMAKLGPDVIT 114
E+ N + QN L +E ++ ++L ++E N+ K I +L + +
Sbjct: 683 FEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 742
Query: 115 EEIN-------IDDEDSTTDTDGAAETCVSVQCQKQI-----KELRDQI---VSVQEEKK 159
+E+ + ++ + E ++ + I K L D + V +E++
Sbjct: 743 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEER 802
Query: 160 ILAIELENLKSK-------LVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVE 212
++ ++ KSK + +IEE +KQ+ LN E+ +QR + + +
Sbjct: 803 LIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ 862
Query: 213 EYEE-----MQVNLELEKDLRKKAESFAQEMFIEQNKLKRQ----SHLLLQSSIPDQQ-- 261
E +E ++V +LE K+ + ++ +L Q + + ++SS+ D+
Sbjct: 863 ELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKT 922
Query: 262 -LLKALD-------ENAKLTQQLE---EERIQHQQKVKELEEQLENETLHKEIHNLKQQL 310
+ + L+ + +L ++LE E+++ Q++ +L EQL+ + H EI L +++
Sbjct: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQK--HGEISFLNEEV 980
Query: 311 ELLEEDKKELELKYQNSE 328
+ L+++K+++ L+ + E
Sbjct: 981 KSLKQEKEQVSLRCRELE 998
Score = 53.5 bits (127), Expect = 4e-07
Identities = 80/385 (20%), Positives = 157/385 (40%), Gaps = 51/385 (13%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
+ +D L I +L Q G L+ E + K + + + ++ E Q
Sbjct: 3074 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3133
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
+ + +Q L EK ++ + E +T + ++ +L E ++
Sbjct: 3134 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL------EAFRLE 3187
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
+D T + +T S Q K+ R+ ++++EK L E K +L ++ +
Sbjct: 3188 VKDKTDEVHLLNDTLASEQ-----KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLE 3242
Query: 181 KVKQEKTVLNSEVLEQRKVL----EKCNRVSMLAVEEYEEMQV-NLELEKDLRKKAESFA 235
KQ LN + +Q+++L +K ML + E Q NLEL+ L +
Sbjct: 3243 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI- 3301
Query: 236 QEMFIEQNKLKRQSHLLLQSS---------IPDQQLLKALD------------------- 267
+EM ++ +R+ H LQSS +P + LLK L
Sbjct: 3302 REMSSTLDR-ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK 3360
Query: 268 ---ENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKY 324
++ + QQ+E++R H++ ++ EQ N K++H L+ ++E L+ +E +
Sbjct: 3361 YKLDSLQTRQQMEKDRQVHRKTLQT--EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3418
Query: 325 QNSEEKARNLKHSVDELQKRVNQSE 349
+ + + L+ + E QK+ + E
Sbjct: 3419 YKLDLEGQRLQGIMQEFQKQELERE 3443
Score = 53.1 bits (126), Expect = 5e-07
Identities = 89/406 (21%), Positives = 168/406 (41%), Gaps = 92/406 (22%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQER---DEAVKKLEEFQKISHMVI 63
EK Q + ++ ++ L E K + D + E+ ++ V+ E V+
Sbjct: 2349 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVL 2408
Query: 64 EEVNFMQNHLEIE----KTCRESAEALATKLNKENKTLKRISMLYMAKLGPD---VITEE 116
+E NF N L E K RES E K+ + +++ +++K P+ V+TE+
Sbjct: 2409 KETNFKMNQLTQELFSLKRERESVE----KIQSIPENSVNVAIDHLSKDKPELEVVLTED 2464
Query: 117 ----------------------INIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQ---- 150
IN++ ++ +A+ QC KQIK++++Q
Sbjct: 2465 ALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE 2524
Query: 151 -------IVSVQE--EKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEV-------L 194
IV++Q+ E+K+ A + ++ +E ++E K Q+ ++SE L
Sbjct: 2525 TEMLQKKIVNLQKIVEEKVAAALVSQIQ---LEAVQEYAKFCQDNQTISSEPERTNIQNL 2581
Query: 195 EQRKVLEKCNRVSMLAVEEYE------EMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQ 248
Q + E + +S L + E EM +L LEK+ Q E+N L+++
Sbjct: 2582 NQLREDELGSDISALTLRISELESQVVEMHTSLILEKE---------QVEIAEKNVLEKE 2632
Query: 249 SHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQ 308
LL +L K L+ N K ++ E++R +V + +L + N
Sbjct: 2633 KKLL--------ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFN--- 2681
Query: 309 QLELLEEDKKELELKYQNSEEKARNLKH-------SVDELQKRVNQ 347
+LE L + + + + +EKA L+ ++ LQK ++Q
Sbjct: 2682 ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727
Score = 49.7 bits (117), Expect = 6e-06
Identities = 59/260 (22%), Positives = 116/260 (44%), Gaps = 45/260 (17%)
Query: 115 EEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLK----- 169
EE +DD S GA ++ ++ + ++ Q E + L ELE ++
Sbjct: 137 EEFGVDDSYSE---QGAQDS------PTHLEMMESELAGKQHEIEELNRELEEMRVTYGT 187
Query: 170 SKLVEVIEEVNKVKQEK---TVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVN---LEL 223
L ++ E +KQ T L + + + R+ ++ R + E+ +++Q+ L+
Sbjct: 188 EGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQA 247
Query: 224 EKDLRKKAESFA--------QEMFIEQNKLKRQSHLL--LQSSIPDQQL-LKALDENAKL 272
+ LR S Q++ Q +L+ Q HLL Q D + + L E K+
Sbjct: 248 SETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV 307
Query: 273 TQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKAR 332
+ +++++++ K EE E ET+ +E++ +++EE+KK LELK +K
Sbjct: 308 YEMEQDKKVENSNK----EEIQEKETIIEELNT-----KIIEEEKKTLELK-----DKLT 353
Query: 333 NLKHSVDELQKRVNQSENSV 352
+ ELQ+++ Q +
Sbjct: 354 TADKLLGELQEQIVQKNQEI 373
Score = 45.4 bits (106), Expect = 1e-04
Identities = 78/376 (20%), Positives = 150/376 (39%), Gaps = 51/376 (13%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAV---KKLEEFQ- 56
+ S + +L+L T+LK Q ++L A + K+K D++ D KK E Q
Sbjct: 3156 LKSELAQTKLELETTLKAQH-KHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW 3214
Query: 57 ----------KISHMVIEEVNFMQNHLEIEKTCRESAEALATK----LNKENKTLKRISM 102
+ EE+ ++ LE +K L + LN+ + ++ M
Sbjct: 3215 ALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRM 3274
Query: 103 LYMAKLGPD----------VITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIV 152
LY A+L + + +E++ I + ST D + E +Q + R +
Sbjct: 3275 LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE--RELHAQLQSSDGTGQSRPPLP 3332
Query: 153 SVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVE 212
S ++ K L +LE S++VE++ E K K + L+ R+ +EK +V ++
Sbjct: 3333 S-EDLLKELQKQLEEKHSRIVELLNETEKYKLDS-------LQTRQQMEKDRQVHRKTLQ 3384
Query: 213 EYEEMQVNLELEK---DLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDEN 269
E + N E +K +L+ K E Q +L+ + + + + Q+L + E
Sbjct: 3385 --TEQEANTEGQKKMHELQSKVEDL-------QRQLEEKRQQVYKLDLEGQRLQGIMQEF 3435
Query: 270 AKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEE 329
K + EE+R + + L E N Q ++ E K+ K
Sbjct: 3436 QKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNG 3495
Query: 330 KARNLKHSVDELQKRV 345
H ++ +++++
Sbjct: 3496 GGTGCNHELEMIRQKL 3511
Score = 42.0 bits (97), Expect = 0.001
Identities = 83/379 (21%), Positives = 155/379 (40%), Gaps = 74/379 (19%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRA----ENQKTKEKCDKIRQERDEAVKKLEEFQ 56
M +E KQ QLI E LRA EN K +++ + ++ E+++ ++E +
Sbjct: 1059 MTVGEESKQEQLILDHLPSVTKE-SSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117
Query: 57 KISHMV----IEEVN-FMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPD 111
+V +++V +M+N E +K E L ++ K L++I L + +
Sbjct: 1118 ICLSLVYSTHVDQVREYMEN--EKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMK-- 1173
Query: 112 VITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQI-----------VSVQEEKKI 160
T+E D+ G + VS +C ++ L + V+ ++++
Sbjct: 1174 --TQETG-DEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENS 1230
Query: 161 LAIELENLKSKLVEVIEEVNKVKQEK-TVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQV 219
EN +L + EV ++ T+LN E K+L R+S + ++ + M++
Sbjct: 1231 GDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKL 1290
Query: 220 NLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEE 279
F E+N K ++ L SI Q LE+
Sbjct: 1291 E------------------FGEENLPKEETEFL---SIHSQMT------------NLEDI 1317
Query: 280 RIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVD 339
+ H+ K+ L++ LE L +++ L+ + L++ KE E Y+ +
Sbjct: 1318 DVNHKSKLSSLQD-LEKTKLEEQVQELESLISSLQQQLKETEQNYEAE----------IH 1366
Query: 340 ELQKRVNQ-SENSVPPPPP 357
LQKR+ SE++VPP P
Sbjct: 1367 CLQKRLQAVSESTVPPSLP 1385
Score = 39.7 bits (91), Expect = 0.006
Identities = 60/328 (18%), Positives = 142/328 (43%), Gaps = 34/328 (10%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
+E+ L++ ++ +A+ EY +NQ + ++ + +++ E IS + +
Sbjct: 2540 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2599
Query: 65 ------EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLY---------MAKLG 109
+V M L +EK E AE L KE K L+ +L K
Sbjct: 2600 ISELESQVVEMHTSLILEKEQVEIAEK--NVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2657
Query: 110 PDVI-----TEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIE 164
P + T E+ +E+S + A SV + ++ +++ +QEE +
Sbjct: 2658 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 2717
Query: 165 LENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELE 224
+ +L+ L +V + + + K++ ++L E ++ +V E + + + +
Sbjct: 2718 MTSLQKDLSQVRDHLAEAKEKLSILEKE--DETEVQESKKACMFEPLPIKLSKSIASQTD 2775
Query: 225 KDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQ 284
L+ + + ++ ++ ++ + LQS +++ + + ++ T+++E+ + H
Sbjct: 2776 GTLKISSSNQTPQILVKNAGIQ----INLQSECSSEEVTEII---SQFTEKIEKMQELHA 2828
Query: 285 QKVKELEEQ--LENETLHKEIHNLKQQL 310
++ ++E + E ETL +E H + QL
Sbjct: 2829 AEILDMESRHISETETLKRE-HYVAVQL 2855
Score = 31.2 bits (69), Expect = 2.0
Identities = 43/202 (21%), Positives = 87/202 (43%), Gaps = 16/202 (7%)
Query: 232 ESFAQEMFIEQNKLKRQSHLLLQSSIPD--QQLLKALDENAKLTQQLEEERIQHQQKVKE 289
+S E+ + RQ +L + + D Q+L++ E+ + T+ L + ++ ++ +E
Sbjct: 1563 QSIHDEISVSSMDASRQL-MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRE 1621
Query: 290 LEEQLENE--TLHKEI--------HNLKQQLE--LLEEDKKELELKYQNSEEKARNLKHS 337
+EQL+ E L++++ NL + E LLEE + +L E+ L++S
Sbjct: 1622 DQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNS 1681
Query: 338 VDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPE 397
+ Q N+++ V L P + ++S R + + K +
Sbjct: 1682 STQTQNG-NENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 398 TTEEVTDLKRQAVEEMMDRIKK 419
TT V + + V ++DR K
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSK 1762
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 78.2 bits (191), Expect = 1e-14
Identities = 91/407 (22%), Positives = 182/407 (44%), Gaps = 74/407 (18%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQ-----------ERD---EAVK 50
D E+Q+ L+++ E DLR +NQ +++ +K+R+ ERD + ++
Sbjct: 2029 DVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQ 2088
Query: 51 KLEE-------FQKISHMVIEEVNFMQNHLEIEKT--CRE---SAEALATKLNKENKTLK 98
KLE+ FQ IS EV + NHL+ EKT C E S E L + + N+ ++
Sbjct: 2089 KLEQQLKVVPRFQPISEHQTREVEQLANHLK-EKTDKCSELLLSKEQLQRDIQERNEEIE 2147
Query: 99 RISMLYMAKLGPDVITEEI--NIDDEDSTTDTDGAAETCVSVQCQKQ---IKELRDQIVS 153
++ +++ + ++D + E + VQ Q + I +I +
Sbjct: 2148 KLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITN 2207
Query: 154 VQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEE 213
++E+ + ELEN ++ ++ ++ K+E T E+ ++ K+ + LA++E
Sbjct: 2208 LEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKE 2267
Query: 214 YEEMQV---------------NLELEKD-LRKKAESFAQEMFI--------EQNKLKRQS 249
+ M E+E D L ++ Q++ I E+N+L R
Sbjct: 2268 SDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL 2327
Query: 250 HLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN---------ETLH 300
++ + DQ+ +K + EEE Q + +++L+++L N +L
Sbjct: 2328 ETQIECLMSDQECVK---------RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLS 2378
Query: 301 KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ 347
+E +LK QL+++ +K LE + + + E+ +K+ + E ++NQ
Sbjct: 2379 EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQ 2425
Score = 62.8 bits (151), Expect = 6e-10
Identities = 89/394 (22%), Positives = 166/394 (42%), Gaps = 83/394 (21%)
Query: 8 KQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVN 67
+QLQ +L+ + A+ + K++ +Q+ +E LE++QK +++
Sbjct: 243 QQLQASETLRNST---HSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQIS 299
Query: 68 FMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEE---INIDDEDS 124
F+Q +++ + ++ K+ NK + + +L +I EE + + D+ +
Sbjct: 300 FLQEKIKVYEMEQDK------KVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLT 353
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSK----------LVE 174
T D K + EL++QIV +E K + +EL N K K L+
Sbjct: 354 TAD--------------KLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399
Query: 175 VIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVE---------------------- 212
+EE+ K + + ++++ QR E ++ L E
Sbjct: 400 TVEELQKRNHKDSQFETDIV-QRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMA 458
Query: 213 EYEEMQVNL--ELEKDLRKKAESFAQEMFIE-QNKLKRQSHLLLQSSIPDQQLLK----- 264
+ EEM+ E+E LR + E I+ N + ++ LQ + ++ LK
Sbjct: 459 QMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL 518
Query: 265 ALDENAKLTQQLEE---------ERIQHQQKVKELEEQLENETLHKE---IHNLKQQLEL 312
L+E L +QLE+ E+IQ ++ +E NE HK + +LK ++
Sbjct: 519 ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEA-HKSLSTVEDLKAEIVS 577
Query: 313 LEEDKKELELKYQNSEEKARNLKHSVDELQKRVN 346
E +KELELK+ E + N K ++ L+K N
Sbjct: 578 ASESRKELELKH---EAEVTNYKIKLEMLEKEKN 608
Score = 62.4 bits (150), Expect = 8e-10
Identities = 94/385 (24%), Positives = 178/385 (46%), Gaps = 41/385 (10%)
Query: 2 NSSDEEKQLQLITSLKEQAI--GEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQK-- 57
NS E+ + +L L+E+ + EDL E ++E+ + RQ E KL E K
Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL 565
Query: 58 --ISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKE------NKTLKRISMLYMAKLG 109
+ + E V+ ++ E+E + AE K+ E N L R++ A+L
Sbjct: 566 STVEDLKAEIVSASESRKELE--LKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELE 623
Query: 110 PDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKEL--RDQIVSVQEEK----KILAI 163
+ ++E S D E ++++ K + + QI +Q E + +
Sbjct: 624 RLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQF 683
Query: 164 ELENLKSKLVEVIEEVNKVKQ-EKTVLNSEVLEQR-KVLEKCNRVSMLAVEEYEEMQVNL 221
E +NL +K ++I E++K+K +++++NS+ E ++ E + +L EE E+ +
Sbjct: 684 EKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQ 743
Query: 222 ELEKDLRKKAESFAQEMFIEQNKLKRQ-SHLLLQSSIPDQQLLKALDENAKL-TQQLEEE 279
E++ +L+ K E ++M ++N L+ + + L ++SI + K L++ K+ T +EE
Sbjct: 744 EVQ-ELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK-KTLEDMLKIHTPVSQEE 801
Query: 280 RIQHQQKVKELEE----QLENETLHKEIHNLKQQLELLEED-----------KKELELKY 324
R+ +K + + E E L +E +LKQQ L E+ +K E+ Y
Sbjct: 802 RLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
Query: 325 QNSEEKARNLKHSVDELQKRVNQSE 349
Q +E+ L D+L+ N+ E
Sbjct: 862 QELQEEYACLLKVKDDLEDSKNKQE 886
Score = 60.5 bits (145), Expect = 3e-09
Identities = 78/358 (21%), Positives = 166/358 (46%), Gaps = 65/358 (18%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
N + E Q++L+ + + +D ++ +K KE+ I +E+ ++LE+
Sbjct: 480 NITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLED------- 532
Query: 62 VIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDD 121
++EE++F + ++ R++ +KLN+ +K+L + L + +E+ +
Sbjct: 533 LVEELSFSREQIQ---RARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKH 589
Query: 122 EDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLV-EVIEEVN 180
E T+ E +K+ + D++ QE ELE L+++L+ EE++
Sbjct: 590 EAEVTNYKIKLE-----MLEKEKNAVLDRMAESQEA------ELERLRTQLLFSHEEELS 638
Query: 181 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 240
K+K++ + E R +EK L + +++ L+ ++ +K E+ F
Sbjct: 639 KLKEDLEI------EHRINIEKLK--DNLGIHYKQQID---GLQNEMSQKIETM---QFE 684
Query: 241 EQNKLKRQSHLLLQ-SSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETL 299
+ N + +Q+ L+L+ S + D Q ++ ++T Q+ E L
Sbjct: 685 KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINE--------------------L 724
Query: 300 HKEIHNLKQQLE---LLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ--SENSV 352
KEI L+Q+ + LE++ +EL+LK +E + +K ++LQ++ Q +ENS+
Sbjct: 725 QKEIEILRQEEKEKGTLEQEVQELQLK---TELLEKQMKEKENDLQEKFAQLEAENSI 779
Score = 56.6 bits (135), Expect = 5e-08
Identities = 57/229 (24%), Positives = 110/229 (48%), Gaps = 23/229 (10%)
Query: 133 ETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSE 192
E S++CQ+ ELR+++ ++ LA+EL SK VI+ EKT+ +
Sbjct: 1888 EATESLKCQE---ELRERLHEESRAREQLAVEL----SKAEGVIDGY---ADEKTLFERQ 1937
Query: 193 VLEQRKVLEKCNRVSMLA---VEEYEEMQVNLELEKDL--RKKAESFAQEMFIEQNKLKR 247
+ E+ ++++ + + A ++E E Q ++ E++L R+K A+ +EQ L+
Sbjct: 1938 IQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE 1997
Query: 248 QSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLK 307
L+ + Q K D+ K + LE + + + ELE++ E + +L+
Sbjct: 1998 TEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELM-----DLR 2052
Query: 308 QQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPP 356
QQ + LE K+LE + +E+A + +H D Q+ + + E + P
Sbjct: 2053 QQNQALE---KQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
Score = 55.8 bits (133), Expect = 8e-08
Identities = 86/381 (22%), Positives = 166/381 (43%), Gaps = 71/381 (18%)
Query: 3 SSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKE-KCDKIRQERDEAVKKLEEF------ 55
++ ++K+ Q +K Q +G E+L+ N K + + D +++ E +KLE+
Sbjct: 381 TNSKQKERQSSEEIK-QLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDE 439
Query: 56 ---QKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDV 112
Q+I M E + +E KT R E + N T+ + M +V
Sbjct: 440 MYGQQIVQMKQELIRQHMAQMEEMKT-RHKGEMENALRSYSNITVNEDQIKLM-----NV 493
Query: 113 ITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKL 172
E+NI +D+ + Q ++L++++ + EEK L +LE
Sbjct: 494 AINELNIKLQDTNS----------------QKEKLKEELGLILEEKCALQRQLE------ 531
Query: 173 VEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYE-EMQVNLELEKDLRKKA 231
+++EE++ +++ + EQ L + ++ S+ VE+ + E+ E K+L K
Sbjct: 532 -DLVEELSFSREQIQRARQTIAEQESKLNEAHK-SLSTVEDLKAEIVSASESRKELELKH 589
Query: 232 ESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ----------LLKALDENAKLTQQLEEER- 280
E+ I+ L+++ + +L Q+ L +E +KL + LE E
Sbjct: 590 EAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHR 649
Query: 281 -----------IQHQQKVKELEEQLEN--ETLHKEIHNL--KQQLELLEEDK-KELELKY 324
I ++Q++ L+ ++ ET+ E NL KQ +LE K K+L+
Sbjct: 650 INIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSL 709
Query: 325 QNSEEKARNLKHSVDELQKRV 345
NS+ + L+ ++ELQK +
Sbjct: 710 VNSKSEEMTLQ--INELQKEI 728
Score = 53.9 bits (128), Expect = 3e-07
Identities = 80/378 (21%), Positives = 170/378 (44%), Gaps = 57/378 (15%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKC-DKIRQERDEAVKKL--EEFQKISHMV 62
E + QL+ S +E+ EDL E++ EK D + + + L E QKI M
Sbjct: 623 ERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQ 682
Query: 63 IEEVNFM--QNHLEIE-KTCRESAEALATKLNKE-----NKTLKRISMLYMAKLGPDVIT 114
E+ N + QN L +E ++ ++L ++E N+ K I +L + +
Sbjct: 683 FEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLE 742
Query: 115 EEIN-------IDDEDSTTDTDGAAETCVSVQCQKQI-----KELRDQI---VSVQEEKK 159
+E+ + ++ + E ++ + I K L D + V +E++
Sbjct: 743 QEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEER 802
Query: 160 ILAIELENLKSK-------LVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVE 212
++ ++ KSK + +IEE +KQ+ LN E+ +QR + + +
Sbjct: 803 LIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQ 862
Query: 213 EYEE-----MQVNLELEKDLRKKAESFAQEMFIEQNKLKRQ----SHLLLQSSIPDQQ-- 261
E +E ++V +LE K+ + ++ +L Q + + ++SS+ D+
Sbjct: 863 ELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKT 922
Query: 262 -LLKALD-------ENAKLTQQLE---EERIQHQQKVKELEEQLENETLHKEIHNLKQQL 310
+ + L+ + +L ++LE E+++ Q++ +L EQL+ + H EI L +++
Sbjct: 923 FVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQK--HGEISFLNEEV 980
Query: 311 ELLEEDKKELELKYQNSE 328
+ L+++K+++ L+ + E
Sbjct: 981 KSLKQEKEQVSLRCRELE 998
Score = 53.5 bits (127), Expect = 4e-07
Identities = 80/385 (20%), Positives = 157/385 (40%), Gaps = 51/385 (13%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
+ +D L I +L Q G L+ E + K + + + ++ E Q
Sbjct: 3082 LQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELS 3141
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
+ + +Q L EK ++ + E +T + ++ +L E ++
Sbjct: 3142 SMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL------EAFRLE 3195
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
+D T + +T S Q K+ R+ ++++EK L E K +L ++ +
Sbjct: 3196 VKDKTDEVHLLNDTLASEQ-----KKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLE 3250
Query: 181 KVKQEKTVLNSEVLEQRKVL----EKCNRVSMLAVEEYEEMQV-NLELEKDLRKKAESFA 235
KQ LN + +Q+++L +K ML + E Q NLEL+ L +
Sbjct: 3251 SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI- 3309
Query: 236 QEMFIEQNKLKRQSHLLLQSS---------IPDQQLLKALD------------------- 267
+EM ++ +R+ H LQSS +P + LLK L
Sbjct: 3310 REMSSTLDR-ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK 3368
Query: 268 ---ENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKY 324
++ + QQ+E++R H++ ++ EQ N K++H L+ ++E L+ +E +
Sbjct: 3369 YKLDSLQTRQQMEKDRQVHRKTLQT--EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQV 3426
Query: 325 QNSEEKARNLKHSVDELQKRVNQSE 349
+ + + L+ + E QK+ + E
Sbjct: 3427 YKLDLEGQRLQGIMQEFQKQELERE 3451
Score = 53.1 bits (126), Expect = 5e-07
Identities = 89/406 (21%), Positives = 168/406 (41%), Gaps = 92/406 (22%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQER---DEAVKKLEEFQKISHMVI 63
EK Q + ++ ++ L E K + D + E+ ++ V+ E V+
Sbjct: 2357 EKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVL 2416
Query: 64 EEVNFMQNHLEIE----KTCRESAEALATKLNKENKTLKRISMLYMAKLGPD---VITEE 116
+E NF N L E K RES E K+ + +++ +++K P+ V+TE+
Sbjct: 2417 KETNFKMNQLTQELFSLKRERESVE----KIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
Query: 117 ----------------------INIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQ---- 150
IN++ ++ +A+ QC KQIK++++Q
Sbjct: 2473 ALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFE 2532
Query: 151 -------IVSVQE--EKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEV-------L 194
IV++Q+ E+K+ A + ++ +E ++E K Q+ ++SE L
Sbjct: 2533 TEMLQKKIVNLQKIVEEKVAAALVSQIQ---LEAVQEYAKFCQDNQTISSEPERTNIQNL 2589
Query: 195 EQRKVLEKCNRVSMLAVEEYE------EMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQ 248
Q + E + +S L + E EM +L LEK+ Q E+N L+++
Sbjct: 2590 NQLREDELGSDISALTLRISELESQVVEMHTSLILEKE---------QVEIAEKNVLEKE 2640
Query: 249 SHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQ 308
LL +L K L+ N K ++ E++R +V + +L + N
Sbjct: 2641 KKLL--------ELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFN--- 2689
Query: 309 QLELLEEDKKELELKYQNSEEKARNLKH-------SVDELQKRVNQ 347
+LE L + + + + +EKA L+ ++ LQK ++Q
Sbjct: 2690 ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2735
Score = 52.4 bits (124), Expect = 9e-07
Identities = 83/357 (23%), Positives = 156/357 (43%), Gaps = 66/357 (18%)
Query: 25 EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAE 84
E L E K + D E+ ++++E I + +E+ N L+ E
Sbjct: 1911 EQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ-------ELE 1963
Query: 85 ALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQI 144
A ++ +E + L R A+ GP ++ +T+ + + VQCQ +
Sbjct: 1964 AEQQQIQEERELLSRQKEAMKAEAGPV---------EQQLLQETEKLMKEKLEVQCQAE- 2013
Query: 145 KELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNK----VKQEKTVLNSEVLEQRKVL 200
++RD + Q++ K L I++E S+ +E+ +E N ++Q+ L ++ + RK L
Sbjct: 2014 -KVRDDL---QKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Query: 201 EK--CNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQ--NKLKRQSHLLLQSS 256
++ +R V + E ++ +L+ R + S Q +EQ N LK ++ +
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELL 2129
Query: 257 IPDQQLLKALDENAKLTQQLEEERIQHQQ----------KVKE--------------LEE 292
+ +QL + + E + ++LE + +Q KV++ LE
Sbjct: 2130 LSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEV 2189
Query: 293 QLENET-----LHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKR 344
QL+ E KEI NL++QLE + ++ELE N E+ + L H E+QK+
Sbjct: 2190 QLQAERDAIDRKEKEITNLEEQLE---QFREELE----NKNEEVQQL-HMQLEIQKK 2238
Score = 49.7 bits (117), Expect = 6e-06
Identities = 59/260 (22%), Positives = 116/260 (44%), Gaps = 45/260 (17%)
Query: 115 EEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLK----- 169
EE +DD S GA ++ ++ + ++ Q E + L ELE ++
Sbjct: 137 EEFGVDDSYSE---QGAQDS------PTHLEMMESELAGKQHEIEELNRELEEMRVTYGT 187
Query: 170 SKLVEVIEEVNKVKQEK---TVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVN---LEL 223
L ++ E +KQ T L + + + R+ ++ R + E+ +++Q+ L+
Sbjct: 188 EGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQA 247
Query: 224 EKDLRKKAESFA--------QEMFIEQNKLKRQSHLL--LQSSIPDQQL-LKALDENAKL 272
+ LR S Q++ Q +L+ Q HLL Q D + + L E K+
Sbjct: 248 SETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKV 307
Query: 273 TQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKAR 332
+ +++++++ K EE E ET+ +E++ +++EE+KK LELK +K
Sbjct: 308 YEMEQDKKVENSNK----EEIQEKETIIEELNT-----KIIEEEKKTLELK-----DKLT 353
Query: 333 NLKHSVDELQKRVNQSENSV 352
+ ELQ+++ Q +
Sbjct: 354 TADKLLGELQEQIVQKNQEI 373
Score = 45.4 bits (106), Expect = 1e-04
Identities = 78/376 (20%), Positives = 150/376 (39%), Gaps = 51/376 (13%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAV---KKLEEFQ- 56
+ S + +L+L T+LK Q ++L A + K+K D++ D KK E Q
Sbjct: 3164 LKSELAQTKLELETTLKAQH-KHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQW 3222
Query: 57 ----------KISHMVIEEVNFMQNHLEIEKTCRESAEALATK----LNKENKTLKRISM 102
+ EE+ ++ LE +K L + LN+ + ++ M
Sbjct: 3223 ALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRM 3282
Query: 103 LYMAKLGPD----------VITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIV 152
LY A+L + + +E++ I + ST D + E +Q + R +
Sbjct: 3283 LYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE--RELHAQLQSSDGTGQSRPPLP 3340
Query: 153 SVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVE 212
S ++ K L +LE S++VE++ E K K + L+ R+ +EK +V ++
Sbjct: 3341 S-EDLLKELQKQLEEKHSRIVELLNETEKYKLDS-------LQTRQQMEKDRQVHRKTLQ 3392
Query: 213 EYEEMQVNLELEK---DLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDEN 269
E + N E +K +L+ K E Q +L+ + + + + Q+L + E
Sbjct: 3393 --TEQEANTEGQKKMHELQSKVEDL-------QRQLEEKRQQVYKLDLEGQRLQGIMQEF 3443
Query: 270 AKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEE 329
K + EE+R + + L E N Q ++ E K+ K
Sbjct: 3444 QKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNG 3503
Query: 330 KARNLKHSVDELQKRV 345
H ++ +++++
Sbjct: 3504 GGTGCNHELEMIRQKL 3519
Score = 42.0 bits (97), Expect = 0.001
Identities = 83/379 (21%), Positives = 155/379 (40%), Gaps = 74/379 (19%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRA----ENQKTKEKCDKIRQERDEAVKKLEEFQ 56
M +E KQ QLI E LRA EN K +++ + ++ E+++ ++E +
Sbjct: 1059 MTVGEESKQEQLILDHLPSVTKE-SSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117
Query: 57 KISHMV----IEEVN-FMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPD 111
+V +++V +M+N E +K E L ++ K L++I L + +
Sbjct: 1118 ICLSLVYSTHVDQVREYMEN--EKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMK-- 1173
Query: 112 VITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQI-----------VSVQEEKKI 160
T+E D+ G + VS +C ++ L + V+ ++++
Sbjct: 1174 --TQETG-DEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENS 1230
Query: 161 LAIELENLKSKLVEVIEEVNKVKQEK-TVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQV 219
EN +L + EV ++ T+LN E K+L R+S + ++ + M++
Sbjct: 1231 GDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKL 1290
Query: 220 NLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEE 279
F E+N K ++ L SI Q LE+
Sbjct: 1291 E------------------FGEENLPKEETEFL---SIHSQMT------------NLEDI 1317
Query: 280 RIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVD 339
+ H+ K+ L++ LE L +++ L+ + L++ KE E Y+ +
Sbjct: 1318 DVNHKSKLSSLQD-LEKTKLEEQVQELESLISSLQQQLKETEQNYEAE----------IH 1366
Query: 340 ELQKRVNQ-SENSVPPPPP 357
LQKR+ SE++VPP P
Sbjct: 1367 CLQKRLQAVSESTVPPSLP 1385
Score = 39.7 bits (91), Expect = 0.006
Identities = 60/328 (18%), Positives = 142/328 (43%), Gaps = 34/328 (10%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
+E+ L++ ++ +A+ EY +NQ + ++ + +++ E IS + +
Sbjct: 2548 EEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLR 2607
Query: 65 ------EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLY---------MAKLG 109
+V M L +EK E AE L KE K L+ +L K
Sbjct: 2608 ISELESQVVEMHTSLILEKEQVEIAEK--NVLEKEKKLLELQKLLEGNEKKQREKEKKRS 2665
Query: 110 PDVI-----TEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIE 164
P + T E+ +E+S + A SV + ++ +++ +QEE +
Sbjct: 2666 PQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETN 2725
Query: 165 LENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELE 224
+ +L+ L +V + + + K++ ++L E ++ +V E + + + +
Sbjct: 2726 MTSLQKDLSQVRDHLAEAKEKLSILEKE--DETEVQESKKACMFEPLPIKLSKSIASQTD 2783
Query: 225 KDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQ 284
L+ + + ++ ++ ++ + LQS +++ + + ++ T+++E+ + H
Sbjct: 2784 GTLKISSSNQTPQILVKNAGIQ----INLQSECSSEEVTEII---SQFTEKIEKMQELHA 2836
Query: 285 QKVKELEEQ--LENETLHKEIHNLKQQL 310
++ ++E + E ETL +E H + QL
Sbjct: 2837 AEILDMESRHISETETLKRE-HYVAVQL 2863
Score = 31.2 bits (69), Expect = 2.0
Identities = 43/202 (21%), Positives = 87/202 (43%), Gaps = 16/202 (7%)
Query: 232 ESFAQEMFIEQNKLKRQSHLLLQSSIPD--QQLLKALDENAKLTQQLEEERIQHQQKVKE 289
+S E+ + RQ +L + + D Q+L++ E+ + T+ L + ++ ++ +E
Sbjct: 1563 QSIHDEISVSSMDASRQL-MLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQRE 1621
Query: 290 LEEQLENE--TLHKEI--------HNLKQQLE--LLEEDKKELELKYQNSEEKARNLKHS 337
+EQL+ E L++++ NL + E LLEE + +L E+ L++S
Sbjct: 1622 DQEQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNS 1681
Query: 338 VDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPE 397
+ Q N+++ V L P + ++S R + + K +
Sbjct: 1682 STQTQNG-NENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVK 1740
Query: 398 TTEEVTDLKRQAVEEMMDRIKK 419
TT V + + V ++DR K
Sbjct: 1741 TTAAVEETIGRHVLGILDRSSK 1762
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 77.8 bits (190), Expect = 2e-14
Identities = 85/357 (23%), Positives = 165/357 (46%), Gaps = 40/357 (11%)
Query: 6 EEKQLQ-LITSLKEQAIGEYEDLRAENQKTKEKCDKIRQER----DEAVKKLEEFQKISH 60
E+ QL+ I +L+E + + + L EN+ + +RQ + VK +E+ KI H
Sbjct: 534 EKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
I+E + + +E EK R+ + L K + + + L+ + +++ ++I
Sbjct: 594 ESIKETSSKLSKIEFEK--RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI--- 648
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
T + + C+K I+ L + ++ E + L L++ K+ + ++
Sbjct: 649 -------------TNLKITCEK-IEALEQENSELERENRKLKKTLDSFKN----LTFQLE 690
Query: 181 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 240
+++E + L+ E LE R+ +E SM + E + LE EK+ KK + F
Sbjct: 691 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFK 749
Query: 241 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN---- 296
+ +L+ L I +Q+L K L+ + K QQLE E + + + L++ LE
Sbjct: 750 KTERLEVSYQGL---DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 297 ----ETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSE 349
E L KE +L+Q+ LE+DKK+LE + + ++A +++E ++ E
Sbjct: 807 SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Score = 65.5 bits (158), Expect = 1e-10
Identities = 70/346 (20%), Positives = 159/346 (45%), Gaps = 44/346 (12%)
Query: 27 LRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEAL 86
+ ENQ+ +K + + E + + L+ Q +S +++E ++ +E T RE++E
Sbjct: 496 MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE---TLRENSERQ 552
Query: 87 ATKLNKENKTLKRI--SMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQI 144
L +EN+ L + S+ +++ + ++I +++ + I
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI----------------LHESI 596
Query: 145 KELRDQIVSVQEEKKILAIELENLKSK---LVEVIEEVNKVKQEKTVLNSEVLEQRKVLE 201
KE ++ ++ EK+ + ELE+ K K E+ E++ +++E +L ++ +
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT-- 654
Query: 202 KCNRVSMLAVEEYEEMQVNLELEKDLRK-KAESFAQEMFIEQNKLKRQSHLLLQSSIPDQ 260
C ++ L E E + N +L+K L K +F E ++N + +L L+ ++
Sbjct: 655 -CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 261 QLLKALDENAKL-TQQLEEERIQHQQ----------KVKELEEQ-----LENETLHKEIH 304
+ +L ++LE E+ Q ++ K + LE +EN+ L K +
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773
Query: 305 NLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSEN 350
N ++++ LE + ++LE++ Q ++ LK S L++ ++++
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Score = 63.9 bits (154), Expect = 3e-10
Identities = 79/350 (22%), Positives = 157/350 (44%), Gaps = 73/350 (20%)
Query: 5 DEEKQLQLITSLKEQAIG------EYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKI 58
D + L+ T L++Q G + +L EN + K K + ERD KK+EE
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL--- 408
Query: 59 SHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN 118
M+ ++ +E ++S + + L E + + R S L A + E+N
Sbjct: 409 ----------MEENMTLEMAQKQSMDE-SLHLGWELEQISRTSELSEAP--QKSLGHEVN 455
Query: 119 IDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQ-EEKKILAIELENLK-SKLVEVI 176
T + + K ++ELR + SV+ KIL +E EN + SK VE++
Sbjct: 456 -----ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 177 EEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQ 236
E +E++++++ L+ C +S ++E +++ +E LR+ +E
Sbjct: 511 E-------------NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET---LRENSE---- 550
Query: 237 EMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN 296
RQ +L Q + Q + +L + ++++ + +VK++E+ EN
Sbjct: 551 ----------RQIKILEQENEHLNQTVSSLRQRSQISAEA---------RVKDIEK--EN 589
Query: 297 ETLHKEIHNLKQQLELLEEDKKELELK---YQNSEEKARNLKHSVDELQK 343
+ LH+ I +L +E +K++++ + Y+ E+A L++ + L+K
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Score = 57.0 bits (136), Expect = 3e-08
Identities = 93/389 (23%), Positives = 165/389 (42%), Gaps = 64/389 (16%)
Query: 5 DEEKQLQLITSLKEQ----AIGEYEDLRAENQ-------KTKEKCDKIRQERDEAVKKLE 53
+ E Q ++SL+++ A +D+ EN+ +T K KI E+ + K+LE
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 54 EFQKISHMVIEEVNFMQNHLEIEK------------TCR--ESAEALATKLNKENKTLKR 99
+++ EE+ +HLE E TC E+ E ++L +EN+ LK+
Sbjct: 619 HYKEKGERA-EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 100 I--SMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSV---QCQKQIKELRDQIVSV 154
S + + E +D+E+ + + C S+ Q Q + KEL
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL------- 730
Query: 155 QEEKKILAIELENLKS--KLVEVIE------EVNKVKQEKTVLNS--EVLEQRKVLEKCN 204
+ EK+ L LE LK+ K E +E ++ + +KT+ NS ++ + L+
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 205 RVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMF-IEQNKL---KRQSHLLLQSSIPDQ 260
+ + EE++++ + + L K+ +S QE +E++K K L Q+ I D
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
Query: 261 QLLKALDENAKLTQQLEEER--------IQHQQKVKELEEQLENETLHKEIHNLKQQLEL 312
L+EN LE+E I + V+ E + EN+ L K + L
Sbjct: 851 ----TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVT 906
Query: 313 LEEDKKELELKYQNSEEKARNLKHSVDEL 341
L ED +LK Q L H ++++
Sbjct: 907 LREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Score = 50.4 bits (119), Expect = 3e-06
Identities = 72/346 (20%), Positives = 161/346 (46%), Gaps = 23/346 (6%)
Query: 24 YEDLRAENQKTKEKCDKIRQERDEAVK-KLEEFQKISHMVIEEVNFMQNHLEIEKTCRES 82
Y+ L ++ + T +K +I++E+ A++ +LEE + + +E+ ++ + E K ++
Sbjct: 954 YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1013
Query: 83 AEALATK--LNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQC 140
+ + ++ E+ +R S +L V I ++ ++T + A Q
Sbjct: 1014 ERMVQSSPPISGEDNKWERESQETTREL-LKVKDRLIEVERNNATLQAEKQALKTQLKQL 1072
Query: 141 QKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVL---NSEVLEQR 197
+ Q L+ QI+++Q + L + L+++ ++ E + + + T L N+++L Q+
Sbjct: 1073 ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ 1132
Query: 198 KVLEKCNRVSMLAVEEYEEMQVNL--ELEK-DLRKKAESFAQEMFIEQNKLKRQSHLLLQ 254
LE N + E+ + + +L + EK +L + ++ E I ++ + +H L+
Sbjct: 1133 SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLE 1192
Query: 255 SSIPD-----QQLLKALDENAKLTQQL--EEERI-----QHQQKVKELEEQL-ENETLHK 301
D QLLK + L + L E+E++ H+ E ++ EN+ L+
Sbjct: 1193 VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNH 1252
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ 347
L ++ E+L+ D K L+ NS+ + L+ +L+++ Q
Sbjct: 1253 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1298
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/208 (22%), Positives = 106/208 (50%), Gaps = 21/208 (10%)
Query: 156 EEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKV-LEKCNRVSMLAVEEY 214
E ++ L++EL + K+K+ + +E+ + K E+ + + LEQ ++ L++ + +M + +
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEE-KTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 215 EEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLL------LQSSIPDQQLLKALDE 268
++ + LR+KA ++ E ++ K + H + ++ D Q+L L+
Sbjct: 303 RSARMYRDELDALREKAVR-VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVL--LET 359
Query: 269 NAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNL-------KQQLELLEEDKKELE 321
L QLE R + K+ ELE+ EN L ++H++ ++++E L E+ LE
Sbjct: 360 KTMLEDQLEGTRAR-SDKLHELEK--ENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416
Query: 322 LKYQNSEEKARNLKHSVDELQKRVNQSE 349
+ + S +++ +L ++++ + SE
Sbjct: 417 MAQKQSMDESLHLGWELEQISRTSELSE 444
Score = 36.6 bits (83), Expect = 0.049
Identities = 37/154 (24%), Positives = 70/154 (45%), Gaps = 9/154 (5%)
Query: 206 VSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKA 265
V+ ++ E+ E + N+ L E IE ++ + H L +S Q +
Sbjct: 178 VTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGS 237
Query: 266 LD-ENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKY 324
+ + Q L E + K++ L ++LE +T +++ + KQ+LE +E + K L+ +
Sbjct: 238 PGMKRTESRQHLSVELADAKAKIRRLRQELEEKT--EQLLDCKQELEQMEIELKRLQQEN 295
Query: 325 QNSEEKARNLKHSVDELQK------RVNQSENSV 352
N AR+ + DEL RV++ E+ V
Sbjct: 296 MNLLSDARSARMYRDELDALREKAVRVDKLESEV 329
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 77.8 bits (190), Expect = 2e-14
Identities = 85/357 (23%), Positives = 165/357 (46%), Gaps = 40/357 (11%)
Query: 6 EEKQLQ-LITSLKEQAIGEYEDLRAENQKTKEKCDKIRQER----DEAVKKLEEFQKISH 60
E+ QL+ I +L+E + + + L EN+ + +RQ + VK +E+ KI H
Sbjct: 534 EKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
I+E + + +E EK R+ + L K + + + L+ + +++ ++I
Sbjct: 594 ESIKETSSKLSKIEFEK--RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI--- 648
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
T + + C+K I+ L + ++ E + L L++ K+ + ++
Sbjct: 649 -------------TNLKITCEK-IEALEQENSELERENRKLKKTLDSFKN----LTFQLE 690
Query: 181 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFI 240
+++E + L+ E LE R+ +E SM + E + LE EK+ KK + F
Sbjct: 691 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFK 749
Query: 241 EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN---- 296
+ +L+ L I +Q+L K L+ + K QQLE E + + + L++ LE
Sbjct: 750 KTERLEVSYQGL---DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 297 ----ETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSE 349
E L KE +L+Q+ LE+DKK+LE + + ++A +++E ++ E
Sbjct: 807 SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
Score = 65.5 bits (158), Expect = 1e-10
Identities = 70/346 (20%), Positives = 159/346 (45%), Gaps = 44/346 (12%)
Query: 27 LRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEAL 86
+ ENQ+ +K + + E + + L+ Q +S +++E ++ +E T RE++E
Sbjct: 496 MEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE---TLRENSERQ 552
Query: 87 ATKLNKENKTLKRI--SMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQI 144
L +EN+ L + S+ +++ + ++I +++ + I
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI----------------LHESI 596
Query: 145 KELRDQIVSVQEEKKILAIELENLKSK---LVEVIEEVNKVKQEKTVLNSEVLEQRKVLE 201
KE ++ ++ EK+ + ELE+ K K E+ E++ +++E +L ++ +
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKIT-- 654
Query: 202 KCNRVSMLAVEEYEEMQVNLELEKDLRK-KAESFAQEMFIEQNKLKRQSHLLLQSSIPDQ 260
C ++ L E E + N +L+K L K +F E ++N + +L L+ ++
Sbjct: 655 -CEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 261 QLLKALDENAKL-TQQLEEERIQHQQ----------KVKELEEQ-----LENETLHKEIH 304
+ +L ++LE E+ Q ++ K + LE +EN+ L K +
Sbjct: 714 KCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLE 773
Query: 305 NLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSEN 350
N ++++ LE + ++LE++ Q ++ LK S L++ ++++
Sbjct: 774 NSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Score = 63.9 bits (154), Expect = 3e-10
Identities = 79/350 (22%), Positives = 157/350 (44%), Gaps = 73/350 (20%)
Query: 5 DEEKQLQLITSLKEQAIG------EYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKI 58
D + L+ T L++Q G + +L EN + K K + ERD KK+EE
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEEL--- 408
Query: 59 SHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN 118
M+ ++ +E ++S + + L E + + R S L A + E+N
Sbjct: 409 ----------MEENMTLEMAQKQSMDE-SLHLGWELEQISRTSELSEAP--QKSLGHEVN 455
Query: 119 IDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQ-EEKKILAIELENLK-SKLVEVI 176
T + + K ++ELR + SV+ KIL +E EN + SK VE++
Sbjct: 456 -----ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 177 EEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQ 236
E +E++++++ L+ C +S ++E +++ +E LR+ +E
Sbjct: 511 E-------------NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET---LRENSE---- 550
Query: 237 EMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN 296
RQ +L Q + Q + +L + ++++ + +VK++E+ EN
Sbjct: 551 ----------RQIKILEQENEHLNQTVSSLRQRSQISAEA---------RVKDIEK--EN 589
Query: 297 ETLHKEIHNLKQQLELLEEDKKELELK---YQNSEEKARNLKHSVDELQK 343
+ LH+ I +L +E +K++++ + Y+ E+A L++ + L+K
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Score = 57.0 bits (136), Expect = 3e-08
Identities = 93/389 (23%), Positives = 165/389 (42%), Gaps = 64/389 (16%)
Query: 5 DEEKQLQLITSLKEQ----AIGEYEDLRAENQ-------KTKEKCDKIRQERDEAVKKLE 53
+ E Q ++SL+++ A +D+ EN+ +T K KI E+ + K+LE
Sbjct: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
Query: 54 EFQKISHMVIEEVNFMQNHLEIEK------------TCR--ESAEALATKLNKENKTLKR 99
+++ EE+ +HLE E TC E+ E ++L +EN+ LK+
Sbjct: 619 HYKEKGERA-EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
Query: 100 I--SMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSV---QCQKQIKELRDQIVSV 154
S + + E +D+E+ + + C S+ Q Q + KEL
Sbjct: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL------- 730
Query: 155 QEEKKILAIELENLKS--KLVEVIE------EVNKVKQEKTVLNS--EVLEQRKVLEKCN 204
+ EK+ L LE LK+ K E +E ++ + +KT+ NS ++ + L+
Sbjct: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
Query: 205 RVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMF-IEQNKL---KRQSHLLLQSSIPDQ 260
+ + EE++++ + + L K+ +S QE +E++K K L Q+ I D
Sbjct: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
Query: 261 QLLKALDENAKLTQQLEEER--------IQHQQKVKELEEQLENETLHKEIHNLKQQLEL 312
L+EN LE+E I + V+ E + EN+ L K + L
Sbjct: 851 ----TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVT 906
Query: 313 LEEDKKELELKYQNSEEKARNLKHSVDEL 341
L ED +LK Q L H ++++
Sbjct: 907 LREDLVSEKLKTQQMNNDLEKLTHELEKI 935
Score = 50.4 bits (119), Expect = 3e-06
Identities = 72/346 (20%), Positives = 161/346 (46%), Gaps = 23/346 (6%)
Query: 24 YEDLRAENQKTKEKCDKIRQERDEAVK-KLEEFQKISHMVIEEVNFMQNHLEIEKTCRES 82
Y+ L ++ + T +K +I++E+ A++ +LEE + + +E+ ++ + E K ++
Sbjct: 953 YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1012
Query: 83 AEALATK--LNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQC 140
+ + ++ E+ +R S +L V I ++ ++T + A Q
Sbjct: 1013 ERMVQSSPPISGEDNKWERESQETTREL-LKVKDRLIEVERNNATLQAEKQALKTQLKQL 1071
Query: 141 QKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVL---NSEVLEQR 197
+ Q L+ QI+++Q + L + L+++ ++ E + + + T L N+++L Q+
Sbjct: 1072 ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ 1131
Query: 198 KVLEKCNRVSMLAVEEYEEMQVNL--ELEK-DLRKKAESFAQEMFIEQNKLKRQSHLLLQ 254
LE N + E+ + + +L + EK +L + ++ E I ++ + +H L+
Sbjct: 1132 SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLE 1191
Query: 255 SSIPD-----QQLLKALDENAKLTQQL--EEERI-----QHQQKVKELEEQL-ENETLHK 301
D QLLK + L + L E+E++ H+ E ++ EN+ L+
Sbjct: 1192 VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNH 1251
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ 347
L ++ E+L+ D K L+ NS+ + L+ +L+++ Q
Sbjct: 1252 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1297
Score = 42.4 bits (98), Expect = 9e-04
Identities = 47/208 (22%), Positives = 106/208 (50%), Gaps = 21/208 (10%)
Query: 156 EEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKV-LEKCNRVSMLAVEEY 214
E ++ L++EL + K+K+ + +E+ + K E+ + + LEQ ++ L++ + +M + +
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEE-KTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
Query: 215 EEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLL------LQSSIPDQQLLKALDE 268
++ + LR+KA ++ E ++ K + H + ++ D Q+L L+
Sbjct: 303 RSARMYRDELDALREKAVR-VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVL--LET 359
Query: 269 NAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNL-------KQQLELLEEDKKELE 321
L QLE R + K+ ELE+ EN L ++H++ ++++E L E+ LE
Sbjct: 360 KTMLEDQLEGTRAR-SDKLHELEK--ENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE 416
Query: 322 LKYQNSEEKARNLKHSVDELQKRVNQSE 349
+ + S +++ +L ++++ + SE
Sbjct: 417 MAQKQSMDESLHLGWELEQISRTSELSE 444
Score = 36.6 bits (83), Expect = 0.049
Identities = 37/154 (24%), Positives = 70/154 (45%), Gaps = 9/154 (5%)
Query: 206 VSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKA 265
V+ ++ E+ E + N+ L E IE ++ + H L +S Q +
Sbjct: 178 VTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGS 237
Query: 266 LD-ENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKY 324
+ + Q L E + K++ L ++LE +T +++ + KQ+LE +E + K L+ +
Sbjct: 238 PGMKRTESRQHLSVELADAKAKIRRLRQELEEKT--EQLLDCKQELEQMEIELKRLQQEN 295
Query: 325 QNSEEKARNLKHSVDELQK------RVNQSENSV 352
N AR+ + DEL RV++ E+ V
Sbjct: 296 MNLLSDARSARMYRDELDALREKAVRVDKLESEV 329
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 76.3 bits (186), Expect = 6e-14
Identities = 84/369 (22%), Positives = 165/369 (44%), Gaps = 56/369 (15%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQ--------- 56
EEK Q + K + GE DL+ + + + + D+++ + KK EE Q
Sbjct: 1046 EEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ---LAKKEEELQGALARGDDE 1102
Query: 57 --------KISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKL 108
K+ + ++ +Q E EK R AE L++E + LK
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKT--------- 1153
Query: 109 GPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENL 168
+ + T DT AA+ + + ++++ EL+ +++EE K +++++
Sbjct: 1154 ------------ELEDTLDTT-AAQQELRTKREQEVAELKK---ALEEETKNHEAQIQDM 1197
Query: 169 KSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLR 228
+ + +EE+++ ++ + + + ++ LE N+ LA E QV E E R
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE--LACEVKVLQQVKAESEHK-R 1254
Query: 229 KKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVK 288
KK ++ QE+ K+ L ++ + +L LD + L ++ E++ I+ +
Sbjct: 1255 KKLDAQVQELHA---KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAA 1311
Query: 289 ELEEQLEN--ETLHKEIH---NLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQK 343
LE QL++ E L +E NL ++ LEE+K L+ + + EE +NL+ V LQ
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371
Query: 344 RVNQSENSV 352
++ ++ V
Sbjct: 1372 QLADTKKKV 1380
Score = 70.9 bits (172), Expect = 2e-12
Identities = 70/341 (20%), Positives = 160/341 (46%), Gaps = 39/341 (11%)
Query: 19 QAIGEYEDLRAENQ---KTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEI 75
Q + E+L+A+++ K KEK K+ E LEE ++ ++EE N + L+
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGE-------LEEMERKHQQLLEEKNILAEQLQA 898
Query: 76 EKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETC 135
E AE + +L + + L+ I +++ + +I +++
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK------------ 946
Query: 136 VSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLE 195
+ Q I++L +Q+ + ++ L +E ++K+ ++ EE+ ++ + NS+ ++
Sbjct: 947 ---KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ----NSKFIK 999
Query: 196 QRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQS 255
++K++E + E EE NL ++ ++ S +E ++ K +++ +
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
Query: 256 SIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQL---ENETLHKE-----IHNLK 307
D + D+ A+L Q++E ++Q +K +EL+ L ++ETLHK + L+
Sbjct: 1060 L--DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117
Query: 308 QQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQS 348
Q+ L+ED + + +E++ R+L ++ L+ + +
Sbjct: 1118 AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT 1158
Score = 64.7 bits (156), Expect = 2e-10
Identities = 81/391 (20%), Positives = 176/391 (45%), Gaps = 50/391 (12%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKE---------KCDKIRQERDEAVKKL 52
N + EK + + E+ + E+L E Q T++ + K + ERD +
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRD- 1584
Query: 53 EEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDV 112
E+ ++ ++I++V ++ LE E+ R A A K+ + K L+ + + A D
Sbjct: 1585 EQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLE--AQIEAANKARDE 1642
Query: 113 ITEEIN-----IDDEDSTTDTDGAAETCV---SVQCQKQIKELRDQIVSVQEE------- 157
+ +++ + D + A+ + S + +K++K L +I+ +QEE
Sbjct: 1643 VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA 1702
Query: 158 -------KKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLA 210
+ LA E+ N S +++E +++ L E+ E++ +E N
Sbjct: 1703 RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT 1762
Query: 211 VEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQ--QLLKALDE 268
+ + + L E+ +K+++ A++ QNK + L+ ++ + + AL+
Sbjct: 1763 TLQVDTLNAELAAERSAAQKSDN-ARQQLERQNKELKAKLQELEGAVKSKFKATISALEA 1821
Query: 269 N-AKLTQQLEEERIQH----------QQKVKELEEQLENETLHKEIHNLKQQLELLEEDK 317
+L +QLE+E + ++K+KE+ Q+E+E H + + K+Q+E
Sbjct: 1822 KIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQY--KEQMEKANARM 1879
Query: 318 KELELKYQNSEEKARNLKHSVDELQKRVNQS 348
K+L+ + + +EE+A S +LQ+ ++ +
Sbjct: 1880 KQLKRQLEEAEEEATRANASRRKLQRELDDA 1910
Score = 61.2 bits (147), Expect = 2e-09
Identities = 70/353 (19%), Positives = 152/353 (43%), Gaps = 32/353 (9%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
E K L L +L E+A+ E+ +N++ + + + +D+ K + E +K + ++
Sbjct: 1482 ETKALSLARAL-EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQ 1540
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDST 125
V M+ LE + ++ E +L + +K A+ D+ T + +++
Sbjct: 1541 VEEMRTQLEELEDELQATEDAKLRLEVNMQAMK-------AQFERDLQTRDEQNEEKKRL 1593
Query: 126 TDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQE 185
+ + ++++ R Q KK + I+L++L+++ IE NK + E
Sbjct: 1594 LIKQVR-------ELEAELEDERKQRALAVASKKKMEIDLKDLEAQ----IEAANKARDE 1642
Query: 186 KTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELE-KDLRKKAESFAQEMFIEQNK 244
V++Q + L+ + +EE + + + K+ KK +S E+ Q +
Sbjct: 1643 -------VIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE 1695
Query: 245 LKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIH 304
L + +L + +A L +E+ + + ++ +LEE+LE E + E+
Sbjct: 1696 LASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELL 1755
Query: 305 NLKQQLELLEEDKKELEL-----KYQNSEEKARNLKHSVDELQKRVNQSENSV 352
N + + L+ D EL Q S+ + L+ EL+ ++ + E +V
Sbjct: 1756 NDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAV 1808
Score = 59.7 bits (143), Expect = 5e-09
Identities = 71/352 (20%), Positives = 150/352 (42%), Gaps = 37/352 (10%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
DE KQ L + K++ + +DL A+ + + RDE +K+L + Q
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQ-------IEAANKARDEVIKQLRKLQ-------A 1652
Query: 65 EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDS 124
++ Q LE + R+ A + + K+ K+L+ + +L + D
Sbjct: 1653 QMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQ 184
D + + S ++ + L +I ++E ELE +S + + + K
Sbjct: 1713 LADEITNSASGKSALLDEK-RRLEARIAQLEE-------ELEEEQSNMELLNDRFRKTTL 1764
Query: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNL-ELEKDLRKKAESFAQEMFIEQN 243
+ LN+E+ +R +K + + +E++ L ELE ++ K ++ + +
Sbjct: 1765 QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIG 1824
Query: 244 KLKRQSHLLLQSSIPDQQLLKALDENAK-LTQQLEEERIQHQQKVKELEEQLENETLHKE 302
+L+ Q + +L++ ++ K + Q+E+ER +H + KE + E +
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER-RHADQYKE-----QMEKANAR 1878
Query: 303 IHNLKQQLELLEED-------KKELELKYQNSEEKARNLKHSVDELQKRVNQ 347
+ LK+QLE EE+ +++L+ + ++ E L V L+ R+ +
Sbjct: 1879 MKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 57.0 bits (136), Expect = 3e-08
Identities = 74/358 (20%), Positives = 162/358 (45%), Gaps = 31/358 (8%)
Query: 6 EEKQLQLITSLKEQA--IGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVI 63
E+ + L T KE A + + ++AE++ ++K D QE K+ E ++ +
Sbjct: 1223 EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHA---KVSEGDRLRVELA 1279
Query: 64 EEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINI---- 119
E+ + +QN L+ T E AE K K+ +L+ + +L + +++N+
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES-QLQDTQELLQEETRQKLNLSSRI 1338
Query: 120 ---DDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQE--EKKILAIE-LENLKSKLV 173
++E ++ E +KQ+ L+ Q+ ++ + + IE LE K KL+
Sbjct: 1339 RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLL 1398
Query: 174 EVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAES 233
+ E +++ +EK + ++ + + L++ + L V+ + QV LEK +K +
Sbjct: 1399 KDAEALSQRLEEKALAYDKLEKTKNRLQQ--ELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 234 FAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQ 293
A+E I + + ++ ++ KAL L + LE + +E E Q
Sbjct: 1457 LAEEKSISARYAEERDRAEAEAR---EKETKALSLARALEEALEAK--------EEFERQ 1505
Query: 294 LENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENS 351
N+ L ++ +L + + ++ ELE + E++ ++ ++EL+ + +E++
Sbjct: 1506 --NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561
Score = 48.9 bits (115), Expect = 9e-06
Identities = 53/256 (20%), Positives = 120/256 (46%), Gaps = 66/256 (25%)
Query: 138 VQCQKQIKELR---DQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQE---KTVLNS 191
+Q +Q +EL+ ++++ V+E++ + ELE ++ K +++EE N + ++ +T L +
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 192 EVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHL 251
E E R + LA ++ E ++ +LE + ++ E + ++ K K Q+H+
Sbjct: 905 EAEEMR---------ARLAAKKQELEEILHDLESRVEEEEE---RNQILQNEKKKMQAHI 952
Query: 252 LLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQL----------------- 294
Q L + LDE Q+L+ E++ + K+K++EE++
Sbjct: 953 --------QDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLM 1004
Query: 295 ----------------ENETLHK-------EIHNLKQQLELLEEDKKELELKYQNSEEKA 331
+ + L K I +L+++L+ E+ ++ELE + + +
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 332 RNLKHSVDELQKRVNQ 347
+L+ + ELQ ++++
Sbjct: 1065 TDLQDQIAELQAQIDE 1080
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/102 (30%), Positives = 56/102 (54%), Gaps = 8/102 (7%)
Query: 259 DQQLLKALDENAKLTQQLEEERIQHQQKVKE---LEEQLENET-LHKEIHNLKQQL---- 310
D++LLK ++ K+ +LEE +HQQ ++E L EQL+ ET L E ++ +L
Sbjct: 858 DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKK 917
Query: 311 ELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
+ LEE +LE + + EE+ + L++ ++Q + E +
Sbjct: 918 QELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQL 959
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 75.9 bits (185), Expect = 7e-14
Identities = 79/376 (21%), Positives = 163/376 (43%), Gaps = 39/376 (10%)
Query: 2 NSSDEEKQLQLITSL----KEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQK 57
N S+E +++Q + K++ G+ A ++T+++ + QE +E +K+ +F K
Sbjct: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK 1683
Query: 58 ISHMVIEEVNFMQNHLEIE-----KTCRESAEALATKLNKENKTLKRISMLY--MAKLGP 110
I E+ + L E T +E E L + + L+R+ M Y ++K
Sbjct: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
Query: 111 DVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEE-KKILAIELENLK 169
+++E+ ++ +E D E VS Q + E D +V EE + + E E
Sbjct: 1744 SLMSEKDSLSEE--VQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQD 1801
Query: 170 SKLVEV----IEEVNKVKQEKTVLNSEVLEQRKV---LEKCNRVSMLAVEEYEEMQVNLE 222
S + E V K ++ + ++ L++ +++ EE Q N E
Sbjct: 1802 SLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKE 1861
Query: 223 LEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQ 282
+ L + + ++ + +LK + + ++ +QQ+ + L KL + EEE+
Sbjct: 1862 FSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDD 1921
Query: 283 HQQKVKE----------------LEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQN 326
++++ + Q++NE L E+ NLK+ + LEE+K++L +
Sbjct: 1922 LEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTK 1981
Query: 327 SEEKARNLKHSVDELQ 342
E + R K ++++Q
Sbjct: 1982 VESEIR--KEYLEKIQ 1995
Score = 72.0 bits (175), Expect = 1e-12
Identities = 87/351 (24%), Positives = 159/351 (45%), Gaps = 60/351 (17%)
Query: 28 RAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKT--------- 78
+ E Q ++ CD ++ E E + +LEE + + H E+ +++ L+ K
Sbjct: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSL 2328
Query: 79 --CRESAEALATKLNKENKTLKRISMLYMAKLGPDV---------ITEEINIDDEDSTTD 127
C+E L + ++ ++ Y +L D+ + EEIN+ ++ +
Sbjct: 2329 EKCKEQKGNLEGIIRQQEADIQNSKFSY-EQLETDLQASRELTSRLHEEINMKEQKIISL 2387
Query: 128 TDGAAETC------VSVQCQKQIKELRDQIVSVQEEKKILAIELENLKS-----KLVEVI 176
G E + Q K+IKEL + + QEE++ + +E EN K+ +L+E +
Sbjct: 2388 LSGKEEAIQVAIAELRQQHDKEIKELENLLS--QEEEENIVLEEENKKAVDKTNQLMETL 2445
Query: 177 EEVNKVK-QEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFA 235
+ + K Q+K L+S V + +R+ + ++ EE +++ LEKD
Sbjct: 2446 KTIKKENIQQKAQLDSFVKSMSSLQNDRDRI-VGDYQQLEERHLSIILEKD------QLI 2498
Query: 236 QEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLE 295
QE E NKLK + L +S + D ENAKL +L IQ+++ +
Sbjct: 2499 QEAAAENNKLKEEIRGL-RSHMDDLN-----SENAKLDAEL----IQYREDL-------- 2540
Query: 296 NETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVN 346
N+ + + KQ LE+ + KELE KY EEK + + + ++L++ N
Sbjct: 2541 NQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFN 2591
Score = 59.3 bits (142), Expect = 7e-09
Identities = 71/328 (21%), Positives = 149/328 (45%), Gaps = 25/328 (7%)
Query: 25 EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAE 84
E+ + + +ERD+ + +++E ++ + + N E E+ R E
Sbjct: 726 EEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYE 785
Query: 85 ALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQ- 143
+ +N ++I L + DV E + + +D V +Q +Q
Sbjct: 786 SQTAH---DNLLTEQIHSLSIEAKSKDVKIEVLQNELDD------------VQLQFSEQS 830
Query: 144 --IKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLE 201
I+ L+ Q+ + + E A + ++ SK+ E+ + +++ + E T ++ +LE+++ +E
Sbjct: 831 TLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVE 890
Query: 202 KCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ 261
+ ++ E+ ++ EK ++ E F+ + +E LK Q +LL ++ ++
Sbjct: 891 TLQQTIEEKDQQVTEISFSMT-EKMVQLNEEKFS--LGVEIKTLKEQLNLLSRAEEAKKE 947
Query: 262 LLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELE 321
++ +E + +Q +E Q KE E Q E + L KE K++L+ ++KEL
Sbjct: 948 QVEEDNEVSSGLKQNYDEMSPAGQISKE-ELQHEFDLLKKENEQRKRKLQAALINRKELL 1006
Query: 322 LKYQNSEEKARNLKHSVDELQKRVNQSE 349
+ EE+ NLK DE +K + SE
Sbjct: 1007 QRVSRLEEELANLK---DESKKEIPLSE 1031
Score = 57.8 bits (138), Expect = 2e-08
Identities = 66/350 (18%), Positives = 147/350 (42%), Gaps = 23/350 (6%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
+EE L + KEQA E++ +E + +++ + + K L I +
Sbjct: 627 NEESSLPAVE--KEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQD 684
Query: 65 EVNFMQNH-LEIEKTCRESAEALATKLNKENKTLKRISMLYMA-KLGPDVITEEINIDDE 122
E+ +++ LE+E ++ E L+++ K + ++ L K D + E
Sbjct: 685 ELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSE 744
Query: 123 DSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKI-----------LAIELENLKSK 171
+ E + + + Q+K+L + + ++++ L ++ +L +
Sbjct: 745 ERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIE 804
Query: 172 LVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKA 231
++ ++ E + + EQ ++ S L +E E ++ E + + K
Sbjct: 805 AKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQ--SQLQNKESEVLE-GAERVRHISSKV 861
Query: 232 ESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELE 291
E +Q + ++ ++ + LLL+ + L + ++E QQ+ E +K+ +L
Sbjct: 862 EELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEK---DQQVTEISFSMTEKMVQLN 918
Query: 292 EQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDEL 341
E E +L EI LK+QL LL ++ + + + E + LK + DE+
Sbjct: 919 E--EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEM 966
Score = 55.8 bits (133), Expect = 8e-08
Identities = 90/367 (24%), Positives = 166/367 (45%), Gaps = 40/367 (10%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRA--ENQKTKEKCDKIRQERDEAVKKLEEFQKIS 59
+S++EE +++ I + + E E+L + + Q T+ + ++ Q E +EEF +
Sbjct: 138 SSTEEEMEIEKI----KHKLQEKEELISTLQAQLTQAQAEQPAQSSTE----MEEFVMMK 189
Query: 60 HMVIEEVNFMQN-HLEIEKT-CRESAEALATKLNKENKTLKRISMLYMAKL--GPDVITE 115
+ E+ F+ ++ +T ++A+ + + + +T R+ + +L DV TE
Sbjct: 190 QQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETE 249
Query: 116 E------INIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELE-NL 168
+ E+ G A+ +Q + E R+QI+S Q ++ +E E N
Sbjct: 250 MQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQ----MEAEHNT 305
Query: 169 KSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEM-QVNLELEKDL 227
VE E +K+ EK L EV E++ +E++E+ Q ELE
Sbjct: 306 LRNTVETEREESKILLEKMEL--EVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRY 363
Query: 228 RKKAESFAQEMFIEQNKLKRQSHLL-LQSSIPD-QQLLKAL-DENAKLTQQLEEERIQHQ 284
+ EM ++ SH+L LQ + + Q AL D+N+KL Q E+ +Q
Sbjct: 364 SALEQKHKAEME------EKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSA 417
Query: 285 QKVKELEEQLENETLHKEIHNLKQQLELLE-EDKKELELKYQNSEEKARNLKHSVDELQK 343
Q +++LE+QL+ ++ KEI +L L + E + +E + ++ LQK
Sbjct: 418 QTIQQLEDQLQQKS--KEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQK 475
Query: 344 RVNQSEN 350
RV + EN
Sbjct: 476 RVVELEN 482
Score = 55.1 bits (131), Expect = 1e-07
Identities = 90/362 (24%), Positives = 155/362 (42%), Gaps = 47/362 (12%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
N DE K+ L E GE E+ + EN++ EKC + + E K Q IS
Sbjct: 1018 NLKDESKKE---IPLSETERGEVEEDK-ENKEYSEKCVTSKCQEIEIYLK----QTISEK 1069
Query: 62 VIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDD 121
+E + ++ LE + E +AL ++N+ + L A++ + + I
Sbjct: 1070 EVE-LQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITS 1128
Query: 122 EDSTTDTDGAA---ETCV-SVQCQKQIKELRDQIVSVQEEKKILAIELEN--LKSKLVEV 175
+D D A ET V S C + + ++ E+KILA+E E L+ KL E
Sbjct: 1129 NTDASDGDSVALVKETVVISPPCTGSSEHWKPEL-----EEKILALEKEKEQLQKKLQEA 1183
Query: 176 I---EEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAE 232
+ + + K QEK E L+Q+K + NR+ E+++E E D ++ +
Sbjct: 1184 LTSRKAILKKAQEKERHLREELKQQK--DDYNRLQ----EQFDEQSKENENIGDQLRQLQ 1237
Query: 233 SFAQEMFIEQNKLKRQSHLLLQSSIP--DQQLLKALDENAKLTQQLEEERI-----QHQQ 285
+E KL SS P ++ L KA +++ TQ + E + H +
Sbjct: 1238 IQVRESI--DGKLPSTDQQESCSSTPGLEEPLFKATEQHH--TQPVLESNLCPDWPSHSE 1293
Query: 286 KVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345
L+ + +K QL+ +E +K ELELK ++ + V +LQ+++
Sbjct: 1294 DASALQGGTS-------VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQI 1346
Query: 346 NQ 347
N+
Sbjct: 1347 NK 1348
Score = 55.1 bits (131), Expect = 1e-07
Identities = 87/411 (21%), Positives = 177/411 (43%), Gaps = 77/411 (18%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
M DE+ + +L EQA E + L+ E + +EK D +R+E+ + + E Q +
Sbjct: 2116 MKQKDEDLERRL-----EQA--EEKHLK-EKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
Query: 61 MVIEEVNFMQNHL--------------------------EIEKTCRESAEALATK----- 89
+EV +Q +L E +K R+ ++A+ +K
Sbjct: 2168 KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Query: 90 LNKENKTLKRISMLYMA------KLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQ-- 141
L ++N ++ + + M+ K+ + + I + + T+ + C ++Q +
Sbjct: 2228 LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK 2287
Query: 142 ---KQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRK 198
Q++E R S Q E L EL++LK +L ++ + K K++K L + +Q
Sbjct: 2288 ELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEA 2347
Query: 199 VLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNK---LKRQSHLLLQS 255
++ + YE+++ +L+ ++L + +E+ +++ K L +Q
Sbjct: 2348 DIQN-------SKFSYEQLETDLQASRELTSRLH---EEINMKEQKIISLLSGKEEAIQV 2397
Query: 256 SIPD--QQLLKALDENAKLTQQLEEERI----QHQQKVKELEEQLEN-ETLHKEIHNLKQ 308
+I + QQ K + E L Q EEE I ++++ V + + +E +T+ KE K
Sbjct: 2398 AIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKA 2457
Query: 309 QLE-------LLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
QL+ L+ D+ + YQ EE+ ++ D+L + N +
Sbjct: 2458 QLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL 2508
Score = 54.7 bits (130), Expect = 2e-07
Identities = 80/364 (21%), Positives = 160/364 (43%), Gaps = 73/364 (20%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDL-RAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
N++ E+ Q +L + EQ + E +D+ R ++ + ++K + +++ER A K+
Sbjct: 44 NTTQEDVQERL--AYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKI-------- 93
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
K + A+A T LNK + +K G V+ E +
Sbjct: 94 ----------------KKLKLHAKAKLTSLNKYIEEMKA--------QGGTVLPTEPQSE 129
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQ--------EEKKILAIELEN---LK 169
++ S D E + + +++E + I ++Q E+ + E+E +K
Sbjct: 130 EQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMK 189
Query: 170 SKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRK 229
+L E E ++ ++ + + +E Q+ V EK R V +E+ + L + D+
Sbjct: 190 QQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFET-QVRLHEDELLQLVTQADVET 248
Query: 230 KAESFAQEMFIEQNKLKRQSHLLL-QSSIPD---QQLLKALDENAKLTQQLEEERIQH-- 283
+ + Q++ + Q KL+ L+ ++ + D Q+L A N L+QQL++ +H
Sbjct: 249 EMQ---QKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNT 305
Query: 284 --------QQKVKELEEQLENET---------LHKEIHNLKQQLELLEEDKKELELKYQN 326
+++ K L E++E E L +E+H+L +Q E + + ELE +Y
Sbjct: 306 LRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSA 365
Query: 327 SEEK 330
E+K
Sbjct: 366 LEQK 369
Score = 53.5 bits (127), Expect = 4e-07
Identities = 68/366 (18%), Positives = 156/366 (42%), Gaps = 43/366 (11%)
Query: 9 QLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIR-------QERDEAVKKLEEFQKISHM 61
+L L+ +++ I E + ENQ C+ ++ +++++ VK++E + S
Sbjct: 1540 RLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK--SSK 1597
Query: 62 VIEEVNFMQNHLEIEKTCR---ESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN 118
+ E + + H E++K +S E ++ + + ++ + G TE
Sbjct: 1598 IAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANK 1657
Query: 119 IDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIE-----------LEN 167
+ E + + E + + +K K + +I+ ++EE L E +E
Sbjct: 1658 KETEKQLQEAEQEMEE-MKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMET 1716
Query: 168 LKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDL 227
L S + EE+ +VK E L+ + + ++ + + +S EE ++++ ++E ++
Sbjct: 1717 LLSSNASMKEELERVKMEYETLSKKF---QSLMSEKDSLS----EEVQDLKH--QIEGNV 1767
Query: 228 RKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKV 287
K+A A E Q + + SIP + +E L+ +
Sbjct: 1768 SKQANLEATEKHDNQTNVTEEG----TQSIPGET-----EEQDSLSMSTRPTCSESVPSA 1818
Query: 288 KELEEQLENE-TLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVN 346
K + + + H EI+N QQ++ L+E LE + Q ++E ++ L++ + L +++
Sbjct: 1819 KSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS 1878
Query: 347 QSENSV 352
+ +
Sbjct: 1879 TKDGEL 1884
Score = 53.5 bits (127), Expect = 4e-07
Identities = 79/357 (22%), Positives = 146/357 (40%), Gaps = 44/357 (12%)
Query: 2 NSSDE-EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
+S DE LQ I LKE+ G L E QK KE + E++ + ++
Sbjct: 1830 SSHDEINNYLQQIDQLKERIAG----LEEEKQKNKEFSQTLENEKNTLLSQISTKDGELK 1885
Query: 61 MVIEEVNFM-------QNHL----EIEKTCRESAEALATKLNKE---------------- 93
M+ EEV M Q L ++++T E + L +L +
Sbjct: 1886 MLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVT 1945
Query: 94 ----NKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRD 149
L M + K ++ E+ + E + +++ E +Q ++ +
Sbjct: 1946 DAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKS 2005
Query: 150 QIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSML 209
+QE K E++ L+ + E+++ +++ L E +K LE
Sbjct: 2006 HAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQ 2065
Query: 210 AVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQS---SIPDQQLLKAL 266
AVE ++ Q L K L +S A + + KLK++ LQS S+ Q K
Sbjct: 2066 AVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKE----LQSNKESVKSQMKQKDE 2121
Query: 267 DENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELK 323
D +L +Q EE+ ++ ++ ++E + L E +H E + Q+ L ++DK+ +L+
Sbjct: 2122 DLERRL-EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQ 2177
Score = 53.1 bits (126), Expect = 5e-07
Identities = 67/334 (20%), Positives = 154/334 (46%), Gaps = 31/334 (9%)
Query: 8 KQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVN 67
K + + + +++ +G+Y+ L + + D++ QE KL+E + ++++N
Sbjct: 2464 KSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLN 2523
Query: 68 FMQNHLEIEKT-CRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTT 126
L+ E RE + T + + K L + + +L E + + +
Sbjct: 2524 SENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEAN 2583
Query: 127 DTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEK 186
+ +LR ++QEEK+ L+ E+E+LK + ++ +V +++E
Sbjct: 2584 E------------------DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEG 2625
Query: 187 TV-LNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKL 245
T+ L L+ ++ E+ +R+S L + + ELE++L + A+++ ++KL
Sbjct: 2626 TLGLYHAQLKVKE--EEVHRLSALFSSSQKRI---AELEEELVCVQKEAAKKVGEIEDKL 2680
Query: 246 KRQ-SHLLLQSSIPDQQLLKALDENAKLTQ---QLEEERIQHQQKVKELEEQLENETLHK 301
K++ HL + I + A + A+L + ++E++ + ++ K L Q+ ++ +
Sbjct: 2681 KKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQI--QSFGR 2738
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLK 335
+ +L+ + E+ EL+ KY S ++ LK
Sbjct: 2739 SMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772
Score = 52.0 bits (123), Expect = 1e-06
Identities = 90/446 (20%), Positives = 183/446 (41%), Gaps = 64/446 (14%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERD-------------EAVKKLE 53
E+ QL + +Q + E E L+ + + + + ++Q+ + E KL+
Sbjct: 1337 EEVFQLQEQINKQGL-EIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395
Query: 54 EFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRI-SMLYMAKLGPDV 112
E QK+ E+V+++ L ++ + + T++ ++ +K + + L M D
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEKEA---ALTKIQTEIIEQEDLIKALHTQLEMQAKEHDE 1452
Query: 113 ITEEINID-DEDSTTDTDGAAETCVSVQCQKQI-------KELRDQIVSVQEEKKILAIE 164
+++ ++ E + E+ Q Q+++ KE + S+QEE +
Sbjct: 1453 RIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGT 1512
Query: 165 LENLKSKLVEVIEEVNKVKQEK------------------TVLNSEVLEQRKVLEKCNRV 206
+E L L +V +V+ +EK T ++ +LE + + C +
Sbjct: 1513 IERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESL 1572
Query: 207 SMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNK-LKRQSHLLLQSSIPDQQLLKA 265
LA+E E + L E + K ++ + E++K L+++ +LLQS
Sbjct: 1573 K-LALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSY--------- 1622
Query: 266 LDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQ 325
EN E ERIQH + E+Q L N K+ + L+E ++E+E +
Sbjct: 1623 --ENVSN----EAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKE 1676
Query: 326 NSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSG 385
+ A++ + + EL++ ++ V P + S+ + +
Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYE 1736
Query: 386 SGAKKEKATQPE---TTEEVTDLKRQ 408
+ +KK ++ E +EEV DLK Q
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQ 1762
Score = 42.7 bits (99), Expect = 7e-04
Identities = 67/343 (19%), Positives = 147/343 (42%), Gaps = 42/343 (12%)
Query: 17 KEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMV---IEEVNFMQNHL 73
K+++ + AE Q K+ ++ +RD +K+L+ Q+ + I E++ ++ L
Sbjct: 2862 KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQL 2921
Query: 74 EIEKTCRESAEALATKLNKENKTLKR-ISMLYMAKLGPDVITEEINIDDEDSTTDTDGAA 132
+ + ++ + + +L +EN + + + L M K ++ + + +D D
Sbjct: 2922 QEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQL 2981
Query: 133 ETCVSVQCQKQIKELRD-----QIVSVQEEKKI-------------LAIELENLKSKLVE 174
Q I+ELR Q + VQ +++ L E E L+++L +
Sbjct: 2982 S-----HLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLND 3036
Query: 175 VIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESF 234
++E+++ + LNS + +LE+ N +S+ + + ++ N + DL
Sbjct: 3037 SLKEIHQKELRIQQLNSNFSQ---LLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVL 3093
Query: 235 AQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQL 294
+++ Q ++ + P ++ N + EE + QQ E ++QL
Sbjct: 3094 EKQV---QELQAGPLNIDVAPGAPQEK-------NGVHRKSDPEELREPQQSFSEAQQQL 3143
Query: 295 ENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHS 337
N +E++ L++ LE + + E +EE+ R L+HS
Sbjct: 3144 CNT--RQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEHS 3184
Score = 40.8 bits (94), Expect = 0.003
Identities = 64/336 (19%), Positives = 147/336 (43%), Gaps = 27/336 (8%)
Query: 16 LKEQAIGEYEDLRAENQKT-KEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLE 74
+KE+ + L + +QK E +++ + EA KK+ E I + +E+ + +
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGE---IEDKLKKELKHLHHDAG 2692
Query: 75 IEKTCRESAEALATKLNKENKTLK-RISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAE 133
I + E+AE +L ++ ++ ++ M+ G + D A E
Sbjct: 2693 IMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE 2752
Query: 134 TCVSVQCQ-----KQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTV 188
++ + K++ +L++Q + +E +L+ ++ S + + K+ Q+
Sbjct: 2753 ELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLS 2812
Query: 189 LNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKD-LRKKAESFAQEMFIEQNKLKR 247
+ ++L LE S V+ + + +L+ E+D L + E F + + K+
Sbjct: 2813 KDEQLLHLSSQLED----SYNQVQSFSKAMASLQNERDHLWNELEKFRKS-----EEGKQ 2863
Query: 248 QSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQ-LENETLHKEIHNL 306
+S +S + Q LK K L+ +R + +++K L++Q L+ E+H L
Sbjct: 2864 RSAAQPSTSPAEVQSLK------KAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPL 2917
Query: 307 KQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQ 342
K QL+ ++ K ++ + ++ + +H + +L+
Sbjct: 2918 KAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLR 2953
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 75.1 bits (183), Expect = 1e-13
Identities = 92/402 (22%), Positives = 187/402 (46%), Gaps = 60/402 (14%)
Query: 5 DEEKQLQLITSLKEQAIGEY-------EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQK 57
D+ ++L +ITS K++ E + L E KTK+ + ++ + F+
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824
Query: 58 IS-------HMVIEEVNFM-QNHLEIEKTCRE---SAEALATKLNKENKTLKRISMLYMA 106
+ MV+EE M Q + + K ++ S AL T+L+ + + L+ +
Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 107 KLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELR------DQIVSVQEEKKI 160
+L +E +++ DST T +T ++ + Q+ ++E++ D + +QE
Sbjct: 885 RLNEMEQLKE-QLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES--- 940
Query: 161 LAIELENLKSKLVEVIE-EVNKVKQEKTVLNSEVLEQR-------KVLEKCNRVSML--- 209
L IE + LKS + + + ++ +Q + L S Q K+ E+ +R +
Sbjct: 941 LQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEEN 1000
Query: 210 ---AVEEYEEMQVNLELEKDLRKK------AESFAQEMFIEQNKL------KRQSHLLLQ 254
+E+++ V ++ ++DL K A+ E+ +Q K+ K + +L+
Sbjct: 1001 TGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLE 1060
Query: 255 SSIPDQQLLKA-LDENAKLTQQLEEE-RI--QHQQKVKELEEQLENETLHKE--IHNLKQ 308
S I +++ LK L EN ++T + +EE R+ +K +E+ Q +N + KE +
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD 1120
Query: 309 QLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSEN 350
+L +EE KE + Q +++ N++ + E+QK++N+ EN
Sbjct: 1121 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIEN 1162
Score = 68.9 bits (167), Expect = 9e-12
Identities = 75/365 (20%), Positives = 171/365 (46%), Gaps = 30/365 (8%)
Query: 4 SDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEA---VKKLEEFQKISH 60
S+ ++++ + KE + L++ K E +++++ ++E +K+ EE +++
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE 1600
Query: 61 MV-IEEVNFMQNHLEIEKTCRESAEA--LATKLNKENKTLKRISMLYMAKLGPDVITEEI 117
+ IE +N EI +ES E K+ N+T ++ M + L T+++
Sbjct: 1601 ALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEK--MCEIEHLKEQFETQKL 1658
Query: 118 NIDDEDSTTDTDGAAETCV---SVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVE 174
N+++ +T+ T + +++ + + + RD + SV+E K+ E + LK L E
Sbjct: 1659 NLEN----IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKV---ERDQLKENLRE 1711
Query: 175 VIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAE-S 233
I + ++E +++ + E ++ ++K + E MQ +LE D K +
Sbjct: 1712 TITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLK 1771
Query: 234 FAQEMFIEQNKLKRQSHLL--LQSSIPDQ-----QLLKALDE-NAKLTQQLEEERIQHQQ 285
+E+ I LK Q + L+ + ++ + K L+ NAKL ++++E + Q
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831
Query: 286 KVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345
+ ++ E + E+ LK+Q++ +LE++ N +K L +++E++ +
Sbjct: 1832 LITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQK---LHENLEEMKSVM 1888
Query: 346 NQSEN 350
+ +N
Sbjct: 1889 KERDN 1893
Score = 64.3 bits (155), Expect = 2e-10
Identities = 68/315 (21%), Positives = 143/315 (45%), Gaps = 34/315 (10%)
Query: 41 IRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRI 100
+R E E +K++E + ++ Q+ LE +K + E +L + ++
Sbjct: 644 LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEK---ELQSAFNEITKL 700
Query: 101 SMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKE---LRDQIVSVQEE 157
+ L K+ D++ N++ E TD + + K+++E LR++++ + E
Sbjct: 701 TSLIDGKVPKDLLC---NLELEGKITD--------LQKELNKEVEENEALREEVILLSEL 749
Query: 158 KKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRK----VLEKCNRVS---MLA 210
K L E+E L+ ++ + EE++ + EK L SEV+ + +LE+ +
Sbjct: 750 KS-LPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATT 808
Query: 211 VEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQS--HLLLQSSIPDQQLLKALDE 268
Y+ + K L E +M +E+N+ Q +L ++ D L E
Sbjct: 809 QSNYKSTDQEFQNFKTLHMDFEQ-KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTE 867
Query: 269 NAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSE 328
+ TQ+L+E+ + Q+++ E+E+ L +++ N L+ +E +K + K Q +
Sbjct: 868 LSYKTQELQEKTREVQERLNEMEQ------LKEQLENRDSTLQTVEREKTLITEKLQQTL 921
Query: 329 EKARNLKHSVDELQK 343
E+ + L D+L++
Sbjct: 922 EEVKTLTQEKDDLKQ 936
Score = 61.2 bits (147), Expect = 2e-09
Identities = 85/440 (19%), Positives = 191/440 (43%), Gaps = 48/440 (10%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
E++ LIT +Q + E + L E K+ + ++ ERD+ + + +M I+
Sbjct: 907 EREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHD---TVNMNIDTQ 963
Query: 67 NFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTT 126
++N LE K +E+ L +K+++E + + M D +++ D+
Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEE--VSRNLHMEENTGETKDEFQQKMVGIDKKQDL 1021
Query: 127 DTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKI------LAIELENLKSKLVEVIEEVN 180
+ V+ + I++ R +QE+ ++ + E E LK+ L E IE
Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI 1081
Query: 181 KVKQEKTVLNSEVLEQRKVLEK---------------CNRVSMLA---------VEEYEE 216
+ ++E +L E+ +Q++++ + C+R++ + ++E ++
Sbjct: 1082 ENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQ 1141
Query: 217 MQVNLELE-KDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQ 275
+N++ E +++KK E+ +N+LK + L +L + L+EN + +
Sbjct: 1142 QLLNVQEEMSEMQKK----INEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKS 1197
Query: 276 LEEERIQHQQKVKELEEQLENETLHKE--IHNLKQQLELLEEDKKELELKYQNSEEKARN 333
+ +ER + +KEL++ E E H I ++ +E+ K + + +E
Sbjct: 1198 ITKER----KVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDE 1253
Query: 334 LKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKA 393
L+ SV E ++ +++ + P + + L+ +++ S + + E
Sbjct: 1254 LRRSVSEKTAQIINTQDLEKSHTKLQEEI--PVLHEEQELLPNVKEVSETQETMNELELL 1311
Query: 394 TQPETTEEVTDLKRQAVEEM 413
T+ TT++ T L R +E +
Sbjct: 1312 TEQSTTKDSTTLARIEMERL 1331
Score = 57.8 bits (138), Expect = 2e-08
Identities = 93/408 (22%), Positives = 176/408 (43%), Gaps = 68/408 (16%)
Query: 8 KQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVN 67
K+ + ++KE +++ L+ ++T K + + ++++++ E+ + + +V E
Sbjct: 1349 KERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQ 1408
Query: 68 FMQN-----HLEIE-----KTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEI 117
F +EIE K +ES + + + + KE L+R+ + ++ D + E I
Sbjct: 1409 FKPKDSALLRIEIEMLGLSKRLQESHDEMKS-VAKEKDDLQRLQEVLQSE--SDQLKENI 1465
Query: 118 N-IDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLV--- 173
I + T+ + C + ++ I ELR + + E + +LE + KL
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI 1525
Query: 174 ----------------EVIEEVNKVKQEK----------TVLNSEVLEQRKVLEKCNRVS 207
EV E+VN++KQ K + S++LE L++
Sbjct: 1526 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI 1585
Query: 208 MLAVEEYEEM---QVNLELEKD---------LRKKAESFAQE-MFIE-------QNKLKR 247
+ ++E EEM Q L++E+D + K ES +E F++ Q K+
Sbjct: 1586 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
Query: 248 QSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEE-QLENETLHKEIHNL 306
HL Q L EN +LTQ L E + + KE ++ + ETL E L
Sbjct: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQL 1705
Query: 307 KQQL-ELLEED-KKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
K+ L E + D +K+ ELK + K + ++D+L+ V++ N +
Sbjct: 1706 KENLRETITRDLEKQEELKIVHMHLKEH--QETIDKLRGIVSEKTNEI 1751
Score = 55.8 bits (133), Expect = 8e-08
Identities = 76/330 (23%), Positives = 147/330 (44%), Gaps = 47/330 (14%)
Query: 23 EYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHL-EIEKTCRE 81
E +DLR+ + K + D++++ E + + E Q EE+ + HL E ++T +
Sbjct: 1687 ERDDLRSVEETLKVERDQLKENLRETITRDLEKQ-------EELKIVHMHLKEHQETIDK 1739
Query: 82 SAEALATKLNKENKTLKRISMLYMAKLGPDV-ITEEINIDDEDSTTDTDGAAETCVSVQC 140
++ K N+ + K + A D+ I EE+ I A + Q
Sbjct: 1740 LRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI------------AHMHLKEQ- 1786
Query: 141 QKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVL 200
Q+ I +LR + ++ + +LEN +KL E I+E+ + + L +V E +K
Sbjct: 1787 QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQK-- 1844
Query: 201 EKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQ---SSI 257
V E E+++ ++ + K E IE L ++ H L+ S +
Sbjct: 1845 ---------KVSEMEQLKKQIKDQSLTLSKLE-------IENLNLAQKLHENLEEMKSVM 1888
Query: 258 PDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDK 317
++ L+ ++E KL + +E +Q + K ++LE Q E +T K+ ++ L E
Sbjct: 1889 KERDNLRRVEETLKLERDQLKESLQ-ETKARDLEIQQELKTARMLSKEHKETVDKLREKI 1947
Query: 318 KELELKYQNSEEKARNLKHSVDELQKRVNQ 347
E ++ + + ++L S DELQK++ +
Sbjct: 1948 SEKTIQISDIQ---KDLDKSKDELQKKIQE 1974
Score = 55.1 bits (131), Expect = 1e-07
Identities = 82/364 (22%), Positives = 158/364 (43%), Gaps = 57/364 (15%)
Query: 17 KEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIE 76
K I + +DL A+N +T D ++ E Q+ +I+E N +Q LE
Sbjct: 1011 KMVGIDKKQDLEAKNTQTLTA--------DVKDNEIIEQQRKIFSLIQEKNELQQMLE-- 1060
Query: 77 KTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITE-EINIDDEDSTTDTDGA-AET 134
+ E L T L KEN + + + LG ++ + EI +++ +G + T
Sbjct: 1061 -SVIAEKEQLKTDL-KENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRT 1118
Query: 135 CVSV-QCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEV 193
C + + ++++KE Q+ Q++ + E+ ++ K+ E+ N++K ++ L
Sbjct: 1119 CDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHME 1178
Query: 194 LEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMF--------IEQNKL 245
E+ ++ +K N E YEE++ + K L++ +SF E IE L
Sbjct: 1179 TERLELAQKLN-------ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGL 1231
Query: 246 KRQS-------HLLLQSSIPDQQLLKALDENAKL--TQQLEEERIQHQQKVKELEEQLEN 296
+ + HL D+ ++ A++ TQ LE+ + Q+++ L E+ E
Sbjct: 1232 QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL 1291
Query: 297 ETLHKEIHNLKQ---QLELLEE---------------DKKELELKYQNSEEKARNLKHSV 338
KE+ ++ +LELL E ++ L K+Q S+E+ ++L
Sbjct: 1292 LPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKER 1351
Query: 339 DELQ 342
D L+
Sbjct: 1352 DNLK 1355
Score = 53.1 bits (126), Expect = 5e-07
Identities = 80/361 (22%), Positives = 157/361 (43%), Gaps = 30/361 (8%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
E ++L+L L E E + + E + KE ERD + E + EE
Sbjct: 1178 ETERLELAQKLNEN-YEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEE 1236
Query: 66 VNFMQNHLE-----IEKTCRESAEALATKLNKEN------KTLKRISMLYMAK-LGPDV- 112
+ HL+ I++ R +E A +N ++ K + I +L+ + L P+V
Sbjct: 1237 LKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVK 1296
Query: 113 -ITE-EINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKS 170
++E + +++ + T+ ++ + + + L ++ QEE K L E +NLK+
Sbjct: 1297 EVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT 1356
Query: 171 KLVEVIEEVNKVKQEKTVLNSEVLEQRKVLE--KCNRVSMLAVEEYEEMQVNLELEKDLR 228
I+E +VK ++ L + E ++ + + L ++E + + E +
Sbjct: 1357 -----IKEALEVKHDQ--LKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQF 1409
Query: 229 KKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVK 288
K +S + IE L ++ L +S + + K D+ +L + L+ E Q ++ +K
Sbjct: 1410 KPKDSALLRIEIEMLGLSKR---LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK 1466
Query: 289 EL-EEQLENETLHKEIH-NLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVN 346
E+ + LE E K H LK+Q E + E + L K + L+ D+LQ ++
Sbjct: 1467 EIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQ 1526
Query: 347 Q 347
+
Sbjct: 1527 E 1527
Score = 48.9 bits (115), Expect = 9e-06
Identities = 91/384 (23%), Positives = 163/384 (42%), Gaps = 73/384 (19%)
Query: 11 QLITSLKE--QAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQ-KISHMVIEEVN 67
Q++++ KE Q + E+ + R + +K K + I++E D + F +I ++ E
Sbjct: 2260 QVLSNRKEMTQFLEEWLNTRFDIEKLK---NGIQKENDRICQVNNFFNNRIIAIMNESTE 2316
Query: 68 FMQNHLEIEKTCRESAEALATK---LNKENKTLKRISMLYMAKLGPDVITEEINIDDEDS 124
F + I K + ++L K L K +TLK S+ A++ P +
Sbjct: 2317 FEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKT-SLASGAQVNP-------------T 2362
Query: 125 TTDTDGAAETCVSVQCQ-KQIKELRDQIVSVQE-----EKKILAIELE-----NLKSKLV 173
T D T + Q ++I+EL + + +E E KI+ ++ E ++ +KL
Sbjct: 2363 TQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQ 2422
Query: 174 EVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAES 233
+ E NK EKT +VL+ + L + +E+ + V ++LEK K A+
Sbjct: 2423 AKVHESNKCL-EKTKETIQVLQDKVALGA--KPYKEEIEDLKMKLVKIDLEK--MKNAKE 2477
Query: 234 FAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQ--------- 284
F +E+ + ++ Q +++++ L EN + +QQ ++ + +
Sbjct: 2478 FEKEISATKATVEYQ-----------KEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNK 2526
Query: 285 -----------QKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARN 333
Q K L + E+ L KEI LKQQ E L + K EL Q+ + +
Sbjct: 2527 PLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKT 2586
Query: 334 LKHSV--DELQKRVNQSENSVPPP 355
K E K+V ENS P
Sbjct: 2587 WKERTLKREAHKQVT-CENSPKSP 2609
Score = 48.5 bits (114), Expect = 1e-05
Identities = 62/307 (20%), Positives = 136/307 (44%), Gaps = 27/307 (8%)
Query: 15 SLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLE 74
+LK Q + E+LR + KE+ + I + R +K + K+S+M + N E
Sbjct: 1764 ALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD---KLSNMQKDLENSNAKLQE 1820
Query: 75 IEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAET 134
+ + + L T N+T K++S M +L + + + + + + + A +
Sbjct: 1821 KIQELKANEHQLITLKKDVNETQKKVSE--MEQLKKQIKDQSLTLSKLE-IENLNLAQKL 1877
Query: 135 CVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVL 194
+++ K + + RD + V+E K+ E + LK L E +++QE
Sbjct: 1878 HENLEEMKSVMKERDNLRRVEETLKL---ERDQLKESLQETKARDLEIQQELKTARMLSK 1934
Query: 195 EQRKVLEKCNRVSMLAVEEYEEMQVNLELEKD-LRKKAESFAQEMFIEQNKLKRQSHLLL 253
E ++ ++K + ++Q +L+ KD L+KK + +L+++ LL
Sbjct: 1935 EHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQ-----------ELQKKELQLL 1983
Query: 254 QSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELL 313
+ K ++E +L +Q E + + Q +++N L K++H +++ ++
Sbjct: 1984 RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ------SVRMDNFQLTKKLHESLEEIRIV 2037
Query: 314 EEDKKEL 320
+++ EL
Sbjct: 2038 AKERDEL 2044
Score = 45.4 bits (106), Expect = 1e-04
Identities = 67/330 (20%), Positives = 152/330 (46%), Gaps = 24/330 (7%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAV--KKLE-EFQKISHMVI 63
++++Q + + + Q I +D+ +K E +Q +D+++ KLE E ++ +
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
Query: 64 EEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDED 123
E + M++ ++ R E L + ++ ++L+ + ++ ++ T + +
Sbjct: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL-EIQQELKTARMLSKEHK 1937
Query: 124 STTDT--DGAAETCVSVQ-CQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
T D + +E + + QK + + +D++ +E + ++L +K + +++N
Sbjct: 1938 ETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKIN 1997
Query: 181 KVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQE--M 238
+++Q K ++ L + V +++ E EE+++ + +LR+ ES E
Sbjct: 1998 EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQ 2057
Query: 239 FI----EQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQL 294
FI E RQ+H + P+++LL D LT+ L E+ ++KEL ++
Sbjct: 2058 FIATLREMIARDRQNHQVK----PEKRLLS--DGQQHLTESLREK----CSRIKELLKRY 2107
Query: 295 ENETLHKE-IHNLKQQLELLEEDKKELELK 323
H E ++ L LE E +KEL ++
Sbjct: 2108 SEMDDHYECLNRLSLDLEKEIEFQKELSMR 2137
Score = 45.1 bits (105), Expect = 1e-04
Identities = 76/370 (20%), Positives = 162/370 (43%), Gaps = 63/370 (17%)
Query: 23 EYEDLRAENQKTKEKCDKIRQERDEAVKKLEE---FQKISHMVIEEVNFM---QNHLEIE 76
E DL+ + ++ + E+D+ + LEE QK+ + IE + M + L ++
Sbjct: 351 EIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQ 410
Query: 77 KTCRESAEALAT----KLNK-------------ENKTLK--RISMLYMAKLGPDVITEEI 117
+ + + T K+NK N T K ++S+ + ++ V +E
Sbjct: 411 QELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSES- 469
Query: 118 NIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIE 177
D +T DT E + + Q + + ++ S++ + L ++ E L+++ E+
Sbjct: 470 --DVFSNTLDTLSEIEWNPATKLLNQ-ENIESELNSLRADYDNLVLDYEQLRTEKEEM-- 524
Query: 178 EVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELE--KDLRKKAESFA 235
K+K++ + E LE++ ++ +EMQ+ E+ K+L K AE +
Sbjct: 525 -ELKLKEKNDLDEFEALERK-------------TKKDQEMQLIHEISNLKNLVKHAEVYN 570
Query: 236 QEMFIEQNKLKRQSHLLLQSSIPDQQLLKALD----ENAKLTQQLEEERIQHQQKVKE-- 289
Q++ +N+L + LL + ++L + +D EN K+ E I+ +++K+
Sbjct: 571 QDL---ENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTL 627
Query: 290 -------LEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQ 342
L+ + E+ L E LK++++ L K++E Q + + K +L+
Sbjct: 628 FDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLE 687
Query: 343 KRVNQSENSV 352
K + + N +
Sbjct: 688 KELQSAFNEI 697
Score = 40.0 bits (92), Expect = 0.004
Identities = 60/255 (23%), Positives = 108/255 (42%), Gaps = 47/255 (18%)
Query: 141 QKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKT------------- 187
+K+I +L+ Q+ V E + A+E + L ++L+E + + KV+ EK
Sbjct: 349 RKEIMDLKKQLEEVSLETRAQAMEKDQL-AQLLEEKDLLQKVQNEKIENLTRMLVTSSSL 407
Query: 188 VLNSEVLEQRK-----VLEKCNRVSMLAVEEYEEMQVNLELEKD------LRKKAESFAQ 236
L E+ +RK L K N++ + + N+ + LR+ ES
Sbjct: 408 TLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCS 467
Query: 237 EMFIEQNKLKRQSH--------LLLQSSIPDQ-QLLKALDENAKLT-QQLEEERIQHQQK 286
E + N L S LL Q +I + L+A +N L +QL E+ + + K
Sbjct: 468 ESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELK 527
Query: 287 VKELEEQLENETLHK------------EIHNLKQQLELLEEDKKELELKYQNSEEKARNL 334
+KE + E E L + EI NLK ++ E ++LE + + E R
Sbjct: 528 LKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREK 587
Query: 335 KHSVDELQKRVNQSE 349
+ + +LQ+ ++ +
Sbjct: 588 EDQIKKLQEYIDSQK 602
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 74.3 bits (181), Expect = 2e-13
Identities = 91/455 (20%), Positives = 206/455 (45%), Gaps = 56/455 (12%)
Query: 19 QAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEF-QKISHMVIEEVNFMQNHLEIEK 77
+A E ++ + ++TKE+ + R E +K+ Q+ + + ++ + +N ++ E+
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907
Query: 78 TCR---ESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAET 134
C +S L K+ + + L+ ++ +++ ++ N++D+ S+ D
Sbjct: 908 RCEGLIKSKILLEAKVKELTERLEEEE-----EMNSELVAKKRNLEDKCSSLKRD----- 957
Query: 135 CVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVL---NS 191
I +L + V++EK +++NL ++ + E ++K+ +EK L +
Sbjct: 958 ---------IDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQ 1008
Query: 192 EVLEQRKVLE-KCN---RVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKR 247
+ L+ +V E K N +++ ++ ++++ +LE EK LR +E+ K K
Sbjct: 1009 QTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRAD---------LERAKRKL 1059
Query: 248 QSHLLL-QSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLH-----K 301
+ L + Q SI D EN K QQ+EE+ + + ++ +L+ ++++E +H K
Sbjct: 1060 EGDLKMSQESIMDL-------ENDK--QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQK 1110
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPP 361
+I L+ ++E LEE+ + E++ +L ++E+ +R+ ++ +
Sbjct: 1111 KIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKK 1170
Query: 362 LPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKR--QAVEEMMDRIKK 419
R L + + + KK+ + E E++ +L+R Q +E+ +K
Sbjct: 1171 REAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKM 1230
Query: 420 GVHLRPVNQTARPKTKPESSKGCESAVDELKGILA 454
+ N A K+K + C + D+ I A
Sbjct: 1231 EIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKA 1265
Score = 62.0 bits (149), Expect = 1e-09
Identities = 75/370 (20%), Positives = 158/370 (42%), Gaps = 49/370 (13%)
Query: 18 EQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLE--- 74
E+ + + E LR EN+ +E+ + ++ E K L+E +K +V +E + +Q LE
Sbjct: 1493 EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE 1552
Query: 75 -------------------------------------IEKTCRESAEALATKLNKENKTL 97
+++ + +AEAL + L+ E ++
Sbjct: 1553 GSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRS- 1611
Query: 98 KRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEE 157
+ ++ K+ D+ EI + + V Q + L D + S ++
Sbjct: 1612 RNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDL 1671
Query: 158 KKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEM 217
K+ LAI +E L+E +EE+ KV E+T + EQ ++L+ +RV +L + +
Sbjct: 1672 KEQLAI-VERRNGLLLEELEEM-KVALEQTERTRRLSEQ-ELLDASDRVQLLHSQNTSLI 1728
Query: 218 QVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLE 277
+LE D+ + + +N ++ + +++ ++L K D +A LE
Sbjct: 1729 NTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSA----HLE 1784
Query: 278 EERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHS 337
+ +Q VK+L+ +L+ E + K+Q++ LE +ELE + +++
Sbjct: 1785 RMKKNLEQTVKDLQHRLD-EAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKG 1843
Query: 338 VDELQKRVNQ 347
+ +++V +
Sbjct: 1844 AHKYERKVKE 1853
Score = 58.5 bits (140), Expect = 1e-08
Identities = 85/368 (23%), Positives = 152/368 (41%), Gaps = 51/368 (13%)
Query: 26 DLRAENQKTKEKCDKIRQERDEAVKKLEE-------FQKISHMVIEEVNFMQNHLEIEKT 78
DL + Q+ +EK K E + K+++ FQK + + ++ +E E T
Sbjct: 1072 DLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT 1131
Query: 79 CRESAEA----LATKLNKENKTLKRISMLYMAKLGPDVITE----EINIDDEDSTTDTDG 130
R E LA +L + ++ L+ S A++ + E ++ D E++T +
Sbjct: 1132 LRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Query: 131 AAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEV---IEEVNKVK---- 183
A T Q + EL +QI ++Q K+ L E LK ++ ++ IE ++K K
Sbjct: 1192 TAATLRKKQADS-VAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250
Query: 184 -----------------QEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKD 226
+++T L ++ Q+ L+ N VEE E + L K
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ 1310
Query: 227 -LRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKA-LDENAKLTQQLEEERIQHQ 284
L ++ E ++M E+ K K LQSS D LL+ +E + +L+ +
Sbjct: 1311 ALTQQLEELKRQME-EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKAN 1369
Query: 285 QKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKR 344
+V + + E + + Q+ E LEE KK+L + Q +EE L+K
Sbjct: 1370 SEVAQWRTKYETDAI--------QRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKT 1421
Query: 345 VNQSENSV 352
+ + V
Sbjct: 1422 KQRLQGEV 1429
Score = 57.4 bits (137), Expect = 3e-08
Identities = 71/371 (19%), Positives = 159/371 (42%), Gaps = 40/371 (10%)
Query: 11 QLITSLKEQAIGEYEDLRAEN------QKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
Q + LK Q E+ +A+N Q ++ CD +R++ +E + E Q+
Sbjct: 1314 QQLEELKRQM---EEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS 1370
Query: 65 EV---------NFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITE 115
EV + +Q E+E+ ++ A+ L + + L K E
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVE 1430
Query: 116 EINIDDEDS-----TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKS 170
++ D E S T D V + ++++ E + ++ + Q+E + L+ EL +++
Sbjct: 1431 DLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRN 1490
Query: 171 KLVEVIEEVNKVKQEKTVLNSE-------VLEQRKVLEKCNRVSMLAVEEYEEMQVNLEL 223
EV++++ +++E L E + E K L++ + L +E ++QV LE
Sbjct: 1491 AYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEE 1550
Query: 224 EKDLRKKAESFAQEMFIEQNKLKRQ-SHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQ 282
+ + ES + +E +++K + +++ +QL + A+ Q + + I+
Sbjct: 1551 VEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIR 1610
Query: 283 HQQKVKELEEQLENETLHKEI---HNLKQ------QLELLEEDKKELELKYQNSEEKARN 333
+ L++++E + EI H+ +Q L ++ K+ +L ++ +
Sbjct: 1611 SRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNED 1670
Query: 334 LKHSVDELQKR 344
LK + +++R
Sbjct: 1671 LKEQLAIVERR 1681
Score = 52.4 bits (124), Expect = 9e-07
Identities = 87/458 (18%), Positives = 189/458 (41%), Gaps = 51/458 (11%)
Query: 4 SDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVI 63
SD ++L+ I+ E+A G N+K + + K+R++ +EA +
Sbjct: 1141 SDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ------------ 1188
Query: 64 EEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDED 123
H T R+ +L ++ L+R+ KL + ++ IDD
Sbjct: 1189 --------HEATAATLRKKQADSVAELGEQIDNLQRVKQ----KLEKEKSELKMEIDDMA 1236
Query: 124 STTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVK 183
S + +++ + C + +++ +I + E++ L +L K++L E++
Sbjct: 1237 SNIEALSKSKSNIERTC-RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRV 1295
Query: 184 QEKTVLNSEVLEQRKVL-EKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQ 242
+EK L S++ + ++ L ++ + EE + + R + ++ EQ
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQ 1355
Query: 243 N-KLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN----- 296
K + Q L +S Q K + + T++LEE + + Q+++E EE E
Sbjct: 1356 EAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKC 1415
Query: 297 ETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPP 356
+L K L+ ++E L D + ++K RN + E ++++++S+ +
Sbjct: 1416 ASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAEL---- 1471
Query: 357 PPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDR 416
RSL + + K + A +E Q ET ++ + ++ ++
Sbjct: 1472 -------EAAQKESRSLSTELFKMRN-----AYEEVVDQLETLRRENKNLQEEISDLTEQ 1519
Query: 417 I-KKGVHLRPVNQTARPKTKPESSKGCESAVDELKGIL 453
I + G +L+ +T K + + A++E++G L
Sbjct: 1520 IAETGKNLQEAEKT--KKLVEQEKSDLQVALEEVEGSL 1555
Score = 41.6 bits (96), Expect = 0.002
Identities = 44/202 (21%), Positives = 95/202 (47%), Gaps = 23/202 (11%)
Query: 169 KSKLVEVIEEVNKVKQEKTVLNSEVL--------EQRKVLEKCNRV--------SMLAVE 212
K+ L+ ++EE+ K + +++ + E +K++E+ + + S + V+
Sbjct: 770 KAGLLGLLEEMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVK 829
Query: 213 EYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIP----DQQLLKALDE 268
+ M + ++ K L K AE+ +EM + +R L +S +++++ L E
Sbjct: 830 HWPWMNLFFKI-KPLLKSAEA-EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQE 887
Query: 269 NAKLTQQLEEERIQHQQKVKELEEQLENETL-HKEIHNLKQQLELLEEDKKELELKYQNS 327
L Q++ E + E ++++ L ++ L ++LE EE EL K +N
Sbjct: 888 KNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNL 947
Query: 328 EEKARNLKHSVDELQKRVNQSE 349
E+K +LK +D+L+ + + E
Sbjct: 948 EDKCSSLKRDIDDLELTLTKVE 969
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 74.3 bits (181), Expect = 2e-13
Identities = 97/440 (22%), Positives = 195/440 (44%), Gaps = 47/440 (10%)
Query: 35 KEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKEN 94
KE+ KI+ E ++ K +E ++ +++E N +Q ++ E AE +L K
Sbjct: 859 KEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTK 918
Query: 95 KTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQC---QKQIKELRDQI 151
L+ AK+ +TE +DE+ A + + +C +K I +L +
Sbjct: 919 IQLE-------AKIKE--VTERA--EDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 152 VSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVL---NSEVLEQRKVLE-KCNRVS 207
V++EK +++NL ++ + E + K+ +EK L + + L+ + E K N ++
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 208 MLAV---EEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHL-LLQSSIPDQQLL 263
+ ++ ++++ +LE EK LR M +E+ K K + L L Q SI D
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLR---------MDLERAKRKLEGDLKLAQESIMDI--- 1075
Query: 264 KALDENAKLTQQLEEERIQHQQKVKELEEQLENET-----LHKEIHNLKQQLELLEEDKK 318
EN K QQL+E+ + + ++ L+ ++E+E L K+I L+ ++E LEE+ +
Sbjct: 1076 ----ENEK--QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 319 ELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIR 378
+E++ +L ++E+ +R+ ++ + R L
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 379 KRSHPSGSGAKKEKATQPETTEEVTDLKR--QAVEEMMDRIKKGVHLRPVNQTARPKTKP 436
+ + + KK + E E++ +L+R Q +E+ +K + N K K
Sbjct: 1190 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249
Query: 437 ESSKGCESAVDELKGILASQ 456
K C + D+L + + +
Sbjct: 1250 NLEKMCRTLEDQLSELKSKE 1269
Score = 62.0 bits (149), Expect = 1e-09
Identities = 84/367 (22%), Positives = 173/367 (47%), Gaps = 52/367 (14%)
Query: 6 EEKQLQLITSLKE-QAIGEYED-----LRAENQKTKEKCDKIRQERDEAVKKLEEFQKIS 59
E+++ +L +L+E +A E+E+ ++ E + K + D+ E+DE + +L K +
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL----KRN 1595
Query: 60 HMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINI 119
H+ I V MQ+ L+ E R A L K+ + ++ I + + ++ + + N
Sbjct: 1596 HIRI--VESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME-IQLNHANRMAAEALRNYRNT 1652
Query: 120 DD--EDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIE 177
+D+ D A + ++L++Q+ V+ +L E+E L++ L E E
Sbjct: 1653 QGILKDTQIHLDDAL---------RSQEDLKEQLAMVERRANLLQAEIEELRATL-EQTE 1702
Query: 178 EVNKVKQEKTV-----------LNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKD 226
K+ +++ + N+ ++ +K LE +S + E + +Q E+
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE--TDISQMQGEMEDILQEARNAEEK 1760
Query: 227 LRKK---AESFAQEMFIEQNKLKRQSHLL--LQSSIPDQQLLKALDENAKLTQQLEEERI 281
+K A A+E+ EQ+ + ++ ++ D QL LDE +L + +++I
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQL--RLDEAEQLALKGGKKQI 1818
Query: 282 QH-QQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKAR--NLKHSV 338
Q + +V+ELE ++E+E + N + L + +++ EL YQ E++ L+ V
Sbjct: 1819 QKLEARVRELEGEVESE----QKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV 1874
Query: 339 DELQKRV 345
D+LQ +V
Sbjct: 1875 DKLQAKV 1881
Score = 59.3 bits (142), Expect = 7e-09
Identities = 72/357 (20%), Positives = 152/357 (42%), Gaps = 25/357 (7%)
Query: 9 QLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNF 68
+L I + E+++ + E L+ EN+ +++ + ++ E K++ E +KI V +E
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 69 MQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN----IDDEDS 124
+Q LE + E E ++ E +K +A+ ++ + N ++ S
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQ 184
T D + + +K +L + + + ++ A L N ++ + I + ++
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN--TQGILKDTQIHL 1663
Query: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAE------SFAQEM 238
+ + + E L+++ L R + L E EE++ LE + RK AE S ++
Sbjct: 1664 DDALRSQEDLKEQ--LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1721
Query: 239 FIEQNKLKRQSHLLLQSSIPDQQ------LLKALDENAKLTQQLEEERIQHQQKVKELEE 292
QN + L++ I Q L +A + K + + + + ++ KE +
Sbjct: 1722 LHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT 1781
Query: 293 QLENETLHKEIHNLKQQLELLEEDKKELELK-----YQNSEEKARNLKHSVDELQKR 344
E + K + + L+L ++ ++L LK Q E + R L+ V+ QKR
Sbjct: 1782 SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1838
Score = 55.5 bits (132), Expect = 1e-07
Identities = 87/401 (21%), Positives = 155/401 (38%), Gaps = 94/401 (23%)
Query: 25 EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAE 84
++ +A + ++ D ++ E D K+ K + ++V+ ++ LE EK R E
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEED----KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 85 ALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDD-------EDSTTDTDGAAETCVS 137
KL + K + M D+ E+ +D+ E S + E +
Sbjct: 1056 RAKRKLEGDLKLAQESIM--------DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG 1107
Query: 138 VQCQKQIKELRDQIVSVQEE--------------KKILAIELENLKSKLVEVIE------ 177
+Q QK+IKEL+ +I ++EE + L+ ELE + +L E
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 178 EVNKVKQ----------EKTVLNSE-------------VLEQRKVLEKCNRVSMLAVEEY 214
E+NK ++ E+ L E V E + ++ RV +E
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1227
Query: 215 EEMQVNLE---------------LEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSS--- 256
EM++ ++ LEK R + ++ E+ + + + L Q
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 257 IPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENE---------TLHKEIHN-- 305
+ + LDE L QL + Q+++EL+ QLE E L H+
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD 1347
Query: 306 -LKQQLELLEEDKKELE--LKYQNSEEKARNLKHSVDELQK 343
L++Q E +E K EL+ L N+E K+ D +Q+
Sbjct: 1348 LLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Score = 50.8 bits (120), Expect = 2e-06
Identities = 68/350 (19%), Positives = 146/350 (41%), Gaps = 34/350 (9%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
E QL + S +E+ DL A+ + + + + ++ DE + + + +++
Sbjct: 1259 EDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQI 1318
Query: 67 NFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTT 126
++ LE E + ALA L D++ E+ ++++S
Sbjct: 1319 EELKRQLEEEIKAKN---ALAHALQSSRHDC-------------DLLREQYE-EEQESKA 1361
Query: 127 DTDGAAETCVSVQCQKQIKELRDQIV---SVQEEKKILAIELENLKSKLVEVIEEVNKVK 183
+ A + Q + K D I ++E KK LA L+ + + V + ++
Sbjct: 1362 ELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLE 1421
Query: 184 QEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLE-LEKDLRKKAESFAQEMFIEQ 242
+ K L +EV + +E+ N A ++ Q N + + + ++K E E+ Q
Sbjct: 1422 KTKQRLQNEVEDLMLDVERTNA----ACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477
Query: 243 NKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKE 302
+ + L + + A +E+ + L+ E QQ++ +L EQ+ K
Sbjct: 1478 KEARSLGTELFK-------IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG--KR 1528
Query: 303 IHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
IH L++ + +E++K EL+ + +E + + + +Q +NQ ++ V
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578
Score = 45.1 bits (105), Expect = 1e-04
Identities = 40/216 (18%), Positives = 103/216 (47%), Gaps = 19/216 (8%)
Query: 137 SVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQ 196
S + +K++ ++++ +++E + + L+ K+V +++E N ++ + + +E
Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ---VQAEAEGL 904
Query: 197 RKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSS 256
E+C+++ ++ +++ E +D E E+ ++ KL+ +
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAED----EEEINAELTAKKRKLEDEC------- 953
Query: 257 IPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEED 316
+L K +D+ ++E+E+ + KVK L E++ L + I L ++ + L+E
Sbjct: 954 ---SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--LDETIAKLTKEKKALQEA 1008
Query: 317 KKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
++ Q E+K L + +L+++V+ E S+
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 74.3 bits (181), Expect = 2e-13
Identities = 97/440 (22%), Positives = 195/440 (44%), Gaps = 47/440 (10%)
Query: 35 KEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKEN 94
KE+ KI+ E ++ K +E ++ +++E N +Q ++ E AE +L K
Sbjct: 859 KEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTK 918
Query: 95 KTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQC---QKQIKELRDQI 151
L+ AK+ +TE +DE+ A + + +C +K I +L +
Sbjct: 919 IQLE-------AKIKE--VTERA--EDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967
Query: 152 VSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVL---NSEVLEQRKVLE-KCNRVS 207
V++EK +++NL ++ + E + K+ +EK L + + L+ + E K N ++
Sbjct: 968 AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1027
Query: 208 MLAV---EEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHL-LLQSSIPDQQLL 263
+ ++ ++++ +LE EK LR M +E+ K K + L L Q SI D
Sbjct: 1028 KAKIKLEQQVDDLEGSLEQEKKLR---------MDLERAKRKLEGDLKLAQESIMDI--- 1075
Query: 264 KALDENAKLTQQLEEERIQHQQKVKELEEQLENET-----LHKEIHNLKQQLELLEEDKK 318
EN K QQL+E+ + + ++ L+ ++E+E L K+I L+ ++E LEE+ +
Sbjct: 1076 ----ENEK--QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIE 1129
Query: 319 ELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIR 378
+E++ +L ++E+ +R+ ++ + R L
Sbjct: 1130 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 379 KRSHPSGSGAKKEKATQPETTEEVTDLKR--QAVEEMMDRIKKGVHLRPVNQTARPKTKP 436
+ + + KK + E E++ +L+R Q +E+ +K + N K K
Sbjct: 1190 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249
Query: 437 ESSKGCESAVDELKGILASQ 456
K C + D+L + + +
Sbjct: 1250 NLEKMCRTLEDQLSELKSKE 1269
Score = 62.0 bits (149), Expect = 1e-09
Identities = 84/367 (22%), Positives = 173/367 (47%), Gaps = 52/367 (14%)
Query: 6 EEKQLQLITSLKE-QAIGEYED-----LRAENQKTKEKCDKIRQERDEAVKKLEEFQKIS 59
E+++ +L +L+E +A E+E+ ++ E + K + D+ E+DE + +L K +
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL----KRN 1595
Query: 60 HMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINI 119
H+ I V MQ+ L+ E R A L K+ + ++ I + + ++ + + N
Sbjct: 1596 HIRI--VESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME-IQLNHANRMAAEALRNYRNT 1652
Query: 120 DD--EDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIE 177
+D+ D A + ++L++Q+ V+ +L E+E L++ L E E
Sbjct: 1653 QGILKDTQIHLDDAL---------RSQEDLKEQLAMVERRANLLQAEIEELRATL-EQTE 1702
Query: 178 EVNKVKQEKTV-----------LNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKD 226
K+ +++ + N+ ++ +K LE +S + E + +Q E+
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE--TDISQMQGEMEDILQEARNAEEK 1760
Query: 227 LRKK---AESFAQEMFIEQNKLKRQSHLL--LQSSIPDQQLLKALDENAKLTQQLEEERI 281
+K A A+E+ EQ+ + ++ ++ D QL LDE +L + +++I
Sbjct: 1761 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQL--RLDEAEQLALKGGKKQI 1818
Query: 282 QH-QQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKAR--NLKHSV 338
Q + +V+ELE ++E+E + N + L + +++ EL YQ E++ L+ V
Sbjct: 1819 QKLEARVRELEGEVESE----QKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV 1874
Query: 339 DELQKRV 345
D+LQ +V
Sbjct: 1875 DKLQAKV 1881
Score = 59.3 bits (142), Expect = 7e-09
Identities = 72/357 (20%), Positives = 152/357 (42%), Gaps = 25/357 (7%)
Query: 9 QLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNF 68
+L I + E+++ + E L+ EN+ +++ + ++ E K++ E +KI V +E
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 69 MQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN----IDDEDS 124
+Q LE + E E ++ E +K +A+ ++ + N ++ S
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQ 184
T D + + +K +L + + + ++ A L N ++ + I + ++
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN--TQGILKDTQIHL 1663
Query: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAE------SFAQEM 238
+ + + E L+++ L R + L E EE++ LE + RK AE S ++
Sbjct: 1664 DDALRSQEDLKEQ--LAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQL 1721
Query: 239 FIEQNKLKRQSHLLLQSSIPDQQ------LLKALDENAKLTQQLEEERIQHQQKVKELEE 292
QN + L++ I Q L +A + K + + + + ++ KE +
Sbjct: 1722 LHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT 1781
Query: 293 QLENETLHKEIHNLKQQLELLEEDKKELELK-----YQNSEEKARNLKHSVDELQKR 344
E + K + + L+L ++ ++L LK Q E + R L+ V+ QKR
Sbjct: 1782 SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKR 1838
Score = 55.5 bits (132), Expect = 1e-07
Identities = 87/401 (21%), Positives = 155/401 (38%), Gaps = 94/401 (23%)
Query: 25 EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAE 84
++ +A + ++ D ++ E D K+ K + ++V+ ++ LE EK R E
Sbjct: 1000 KEKKALQEAHQQTLDDLQAEED----KVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 85 ALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDD-------EDSTTDTDGAAETCVS 137
KL + K + M D+ E+ +D+ E S + E +
Sbjct: 1056 RAKRKLEGDLKLAQESIM--------DIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG 1107
Query: 138 VQCQKQIKELRDQIVSVQEE--------------KKILAIELENLKSKLVEVIE------ 177
+Q QK+IKEL+ +I ++EE + L+ ELE + +L E
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 178 EVNKVKQ----------EKTVLNSE-------------VLEQRKVLEKCNRVSMLAVEEY 214
E+NK ++ E+ L E V E + ++ RV +E
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1227
Query: 215 EEMQVNLE---------------LEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSS--- 256
EM++ ++ LEK R + ++ E+ + + + L Q
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 257 IPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENE---------TLHKEIHN-- 305
+ + LDE L QL + Q+++EL+ QLE E L H+
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCD 1347
Query: 306 -LKQQLELLEEDKKELE--LKYQNSEEKARNLKHSVDELQK 343
L++Q E +E K EL+ L N+E K+ D +Q+
Sbjct: 1348 LLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Score = 50.8 bits (120), Expect = 2e-06
Identities = 68/350 (19%), Positives = 146/350 (41%), Gaps = 34/350 (9%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
E QL + S +E+ DL A+ + + + + ++ DE + + + +++
Sbjct: 1259 EDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQI 1318
Query: 67 NFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTT 126
++ LE E + ALA L D++ E+ ++++S
Sbjct: 1319 EELKRQLEEEIKAKN---ALAHALQSSRHDC-------------DLLREQYE-EEQESKA 1361
Query: 127 DTDGAAETCVSVQCQKQIKELRDQIV---SVQEEKKILAIELENLKSKLVEVIEEVNKVK 183
+ A + Q + K D I ++E KK LA L+ + + V + ++
Sbjct: 1362 ELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLE 1421
Query: 184 QEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLE-LEKDLRKKAESFAQEMFIEQ 242
+ K L +EV + +E+ N A ++ Q N + + + ++K E E+ Q
Sbjct: 1422 KTKQRLQNEVEDLMLDVERTNA----ACAALDKKQRNFDKILAEWKQKCEETHAELEASQ 1477
Query: 243 NKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKE 302
+ + L + + A +E+ + L+ E QQ++ +L EQ+ K
Sbjct: 1478 KEARSLGTELFK-------IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG--KR 1528
Query: 303 IHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
IH L++ + +E++K EL+ + +E + + + +Q +NQ ++ V
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1578
Score = 45.1 bits (105), Expect = 1e-04
Identities = 40/216 (18%), Positives = 103/216 (47%), Gaps = 19/216 (8%)
Query: 137 SVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQ 196
S + +K++ ++++ +++E + + L+ K+V +++E N ++ + + +E
Sbjct: 848 SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ---VQAEAEGL 904
Query: 197 RKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSS 256
E+C+++ ++ +++ E +D E E+ ++ KL+ +
Sbjct: 905 ADAEERCDQLIKTKIQLEAKIKEVTERAED----EEEINAELTAKKRKLEDEC------- 953
Query: 257 IPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEED 316
+L K +D+ ++E+E+ + KVK L E++ L + I L ++ + L+E
Sbjct: 954 ---SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--LDETIAKLTKEKKALQEA 1008
Query: 317 KKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
++ Q E+K L + +L+++V+ E S+
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL 1044
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 73.9 bits (180), Expect = 3e-13
Identities = 112/461 (24%), Positives = 187/461 (40%), Gaps = 126/461 (27%)
Query: 11 QLITSLKE--QAIGEYEDLRA---ENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
+L T +K Q + E+++A E QKTKE+ K E L+E ++ + EE
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEE 888
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKL------GPDVITE---- 115
N +Q L+ E AE + +L + + L+ I A+L G + E
Sbjct: 889 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948
Query: 116 -EINIDDEDSTTDTDGAAE--TCVSVQCQKQIKELRDQIV-------SVQEEKKILAIEL 165
+ +D E+ + + A + V + +IK+L D+I+ + +E+K+L +
Sbjct: 949 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 166 ENLKSKLVEVIEEVN-----KVKQEKTVLNSEVL-----EQRKVLEKCNR---------- 205
+L + L E E+ K K E + EV + R+ LEK R
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 206 ------------VSMLAVEEYEEMQVNL-------------------------ELEKDL- 227
+ M ++ EE+Q L +L++DL
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 228 -----RKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ-----------LLKALDENAK 271
R KAE +++ E LK + L S+ Q+ L KALDE +
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 272 LTQ-QLEEERIQHQQKVKELEEQLE------------NETLHKEIHNLKQQLELL----- 313
+ Q++E R +H Q V+EL EQLE +TL KE +L +L +L
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 314 --EEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
E KK+LE + Q + K + + + EL +V++ +N V
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Score = 66.2 bits (160), Expect = 6e-11
Identities = 92/421 (21%), Positives = 184/421 (43%), Gaps = 75/421 (17%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
N ++EE++ + +T LK + +E + +E + +K +K RQE ++ +KLE H
Sbjct: 1014 NLAEEEEKAKNLTKLKNK----HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 62 VIEEVNFMQNHLEIEKTCRESA-EALATKLNKE----NKTLKRISML--YMAKLGPDVIT 114
I ++ L+++ +E +A +L+ E N LK+I L +++ L D+ +
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 115 EEI----------NIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSV-----QEEKK 159
E ++ +E T+ +T S Q++++ R+Q V+V EE +
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTE-LEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 160 ILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCN-------RVSMLAVE 212
+++ ++ K + +EE+ + ++ + + + ++ LEK N RV A +
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 213 EYEEMQVNLELE-KDLRKKA---ESFAQEMFIEQNKLKRQSHLL---------------- 252
E E + LE + ++L+ K E E+ + +KL+ + +
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 253 ----LQSSIPDQQLLKALDENAKLT-----QQLEEERIQHQQKVKELEEQLENETLH--- 300
L S + D Q L + KL +QLEEER Q ++ E E +N H
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 301 ---------KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENS 351
K++ + +E LEE KK + + +N ++ + D+L+K N+ +
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 352 V 352
+
Sbjct: 1429 L 1429
Score = 65.1 bits (157), Expect = 1e-10
Identities = 71/350 (20%), Positives = 151/350 (43%), Gaps = 46/350 (13%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
DE KQ L + K++ G+ +DL + D + R+EA+K+L + Q
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQ-------ADSAIKGREEAIKQLRKLQ-------A 1652
Query: 65 EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDS 124
++ Q LE + R+ A A + K+ K+L+ M
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM---------------------- 1690
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQ 184
D AA Q + +EL +++ S + L E L++++ ++ EE+ + +
Sbjct: 1691 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNK 244
++ V RK ++ ++S E Q N + L ++ + ++ +
Sbjct: 1751 NMEAMSDRV---RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807
Query: 245 LK---RQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHK 301
+K + + L++ I QL + +++ A+ Q + Q +K+KE+ Q+E+E K
Sbjct: 1808 VKSKFKSTIAALEAKI--AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE--RK 1863
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENS 351
K+Q E K+L+ + + +EE+++ + + +LQ+ ++++ S
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Score = 59.3 bits (142), Expect = 7e-09
Identities = 84/382 (21%), Positives = 158/382 (41%), Gaps = 48/382 (12%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
E Q+Q + QA+ E + + ++ K DK +Q ++ L ++ +EV
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 67 NFMQNHLE-----IEKTCRESAEALATKLNKENKTLKRIS----MLYMA-----KLGPDV 112
+ LE ++ C + A A +K +K + ML A KL DV
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 113 ITEEINIDDEDSTTDTDGAAETCVSV---QCQKQIKELRDQIVSVQEEKK-------ILA 162
+ + D + + VS Q +++ L+DQ+ E K+ L
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 163 IELENLKSKL------VEVIEEVNK-VKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYE 215
I+L + K KL VE +EE K ++E L + E+ +K + +E +
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 216 EMQVNLE----LEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAK 271
++ V+L+ L +L KK F Q + E+N + S D++ + K
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN---------ISSKYADERDRAEAEAREK 1481
Query: 272 LTQQLEEERIQHQQKVKELEEQLE--NETLHKEIHNLKQQLELLEEDKKELELKYQNSEE 329
T+ L R ++ E +E+LE N+ L E+ +L + + ++ ELE + E
Sbjct: 1482 ETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 330 KARNLKHSVDELQKRVNQSENS 351
+ +K ++EL+ + +E++
Sbjct: 1540 QMEEMKTQLEELEDELQATEDA 1561
Score = 59.3 bits (142), Expect = 7e-09
Identities = 64/353 (18%), Positives = 145/353 (41%), Gaps = 32/353 (9%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
E K L L +L E+A+ E+L N+ K + + + +D+ K + E +K + +
Sbjct: 1482 ETKALSLARAL-EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDST 125
+ M+ LE + ++ E +L + LK ++ DE +
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALK------------GQFERDLQARDEQNE 1588
Query: 126 TDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQE 185
Q Q+Q+ E ++ ++++ + A + L+ L ++ + + +
Sbjct: 1589 EKRR---------QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 186 KTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNL-ELEKDLRKKAESFAQEMFIEQNK 244
+ E ++Q + L+ + +E+ + + K+ KKA+S ++ Q
Sbjct: 1640 R----EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 245 LKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN-----ETL 299
L Q+ + ++L + L + L++E+ + + ++ +LEE+LE E +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 300 HKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
+ QQ E L + Q +E + L+ EL+ ++++ E +V
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Score = 50.8 bits (120), Expect = 2e-06
Identities = 71/335 (21%), Positives = 147/335 (43%), Gaps = 63/335 (18%)
Query: 6 EEKQLQLITSLK--EQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVI 63
++ +LQ +++K E+AI + L+A+ + + + + R RDE +E +K + +
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Query: 64 EEVNFMQNHLEIEKTCR--------ESAEALATKLNKEN--KTLKRISMLYMAKLGPDVI 113
++ +Q L + R E AE LA+ L+ N + KR +A+L ++
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 114 TEEINID-----------------DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQ- 155
E+ N++ +E +T + Q ++Q KELR ++ ++
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 156 EEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYE 215
K + L++K+ ++ E+V + +EK + ++ K L++ +L VE
Sbjct: 1807 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI----LLQVE--- 1859
Query: 216 EMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQ 275
D RK AE + ++ ++K QL + L+E + +Q+
Sbjct: 1860 ----------DERKMAEQYKEQAEKGNARVK--------------QLKRQLEEAEEESQR 1895
Query: 276 LEEERIQHQQKVKELEEQLENETLHKEIHNLKQQL 310
+ R + Q+++ E E NE + +E++ LK +L
Sbjct: 1896 INANRRKLQRELDEATE--SNEAMGREVNALKSKL 1928
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 73.9 bits (180), Expect = 3e-13
Identities = 112/461 (24%), Positives = 187/461 (40%), Gaps = 126/461 (27%)
Query: 11 QLITSLKE--QAIGEYEDLRA---ENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
+L T +K Q + E+++A E QKTKE+ K E L+E ++ + EE
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEE 895
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKL------GPDVITE---- 115
N +Q L+ E AE + +L + + L+ I A+L G + E
Sbjct: 896 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955
Query: 116 -EINIDDEDSTTDTDGAAE--TCVSVQCQKQIKELRDQIV-------SVQEEKKILAIEL 165
+ +D E+ + + A + V + +IK+L D+I+ + +E+K+L +
Sbjct: 956 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 166 ENLKSKLVEVIEEVN-----KVKQEKTVLNSEVL-----EQRKVLEKCNR---------- 205
+L + L E E+ K K E + EV + R+ LEK R
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 206 ------------VSMLAVEEYEEMQVNL-------------------------ELEKDL- 227
+ M ++ EE+Q L +L++DL
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 228 -----RKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ-----------LLKALDENAK 271
R KAE +++ E LK + L S+ Q+ L KALDE +
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 272 LTQ-QLEEERIQHQQKVKELEEQLE------------NETLHKEIHNLKQQLELL----- 313
+ Q++E R +H Q V+EL EQLE +TL KE +L +L +L
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 314 --EEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
E KK+LE + Q + K + + + EL +V++ +N V
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Score = 66.2 bits (160), Expect = 6e-11
Identities = 92/421 (21%), Positives = 184/421 (43%), Gaps = 75/421 (17%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
N ++EE++ + +T LK + +E + +E + +K +K RQE ++ +KLE H
Sbjct: 1021 NLAEEEEKAKNLTKLKNK----HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 62 VIEEVNFMQNHLEIEKTCRESA-EALATKLNKE----NKTLKRISML--YMAKLGPDVIT 114
I ++ L+++ +E +A +L+ E N LK+I L +++ L D+ +
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 115 EEI----------NIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSV-----QEEKK 159
E ++ +E T+ +T S Q++++ R+Q V+V EE +
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTE-LEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 160 ILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCN-------RVSMLAVE 212
+++ ++ K + +EE+ + ++ + + + ++ LEK N RV A +
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 213 EYEEMQVNLELE-KDLRKKA---ESFAQEMFIEQNKLKRQSHLL---------------- 252
E E + LE + ++L+ K E E+ + +KL+ + +
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 253 ----LQSSIPDQQLLKALDENAKLT-----QQLEEERIQHQQKVKELEEQLENETLH--- 300
L S + D Q L + KL +QLEEER Q ++ E E +N H
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 301 ---------KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENS 351
K++ + +E LEE KK + + +N ++ + D+L+K N+ +
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 352 V 352
+
Sbjct: 1436 L 1436
Score = 65.1 bits (157), Expect = 1e-10
Identities = 71/350 (20%), Positives = 151/350 (43%), Gaps = 46/350 (13%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
DE KQ L + K++ G+ +DL + D + R+EA+K+L + Q
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQ-------ADSAIKGREEAIKQLRKLQ-------A 1659
Query: 65 EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDS 124
++ Q LE + R+ A A + K+ K+L+ M
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLM---------------------- 1697
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQ 184
D AA Q + +EL +++ S + L E L++++ ++ EE+ + +
Sbjct: 1698 QLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNK 244
++ V RK ++ ++S E Q N + L ++ + ++ +
Sbjct: 1758 NMEAMSDRV---RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814
Query: 245 LK---RQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHK 301
+K + + L++ I QL + +++ A+ Q + Q +K+KE+ Q+E+E K
Sbjct: 1815 VKSKFKSTIAALEAKI--AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE--RK 1870
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENS 351
K+Q E K+L+ + + +EE+++ + + +LQ+ ++++ S
Sbjct: 1871 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Score = 59.3 bits (142), Expect = 7e-09
Identities = 84/382 (21%), Positives = 158/382 (41%), Gaps = 48/382 (12%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
E Q+Q + QA+ E + + ++ K DK +Q ++ L ++ +EV
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 67 NFMQNHLE-----IEKTCRESAEALATKLNKENKTLKRIS----MLYMA-----KLGPDV 112
+ LE ++ C + A A +K +K + ML A KL DV
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 113 ITEEINIDDEDSTTDTDGAAETCVSV---QCQKQIKELRDQIVSVQEEKK-------ILA 162
+ + D + + VS Q +++ L+DQ+ E K+ L
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 163 IELENLKSKL------VEVIEEVNK-VKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYE 215
I+L + K KL VE +EE K ++E L + E+ +K + +E +
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 216 EMQVNLE----LEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAK 271
++ V+L+ L +L KK F Q + E+N + S D++ + K
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN---------ISSKYADERDRAEAEAREK 1488
Query: 272 LTQQLEEERIQHQQKVKELEEQLE--NETLHKEIHNLKQQLELLEEDKKELELKYQNSEE 329
T+ L R ++ E +E+LE N+ L E+ +L + + ++ ELE + E
Sbjct: 1489 ETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 330 KARNLKHSVDELQKRVNQSENS 351
+ +K ++EL+ + +E++
Sbjct: 1547 QMEEMKTQLEELEDELQATEDA 1568
Score = 59.3 bits (142), Expect = 7e-09
Identities = 64/353 (18%), Positives = 145/353 (41%), Gaps = 32/353 (9%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
E K L L +L E+A+ E+L N+ K + + + +D+ K + E +K + +
Sbjct: 1489 ETKALSLARAL-EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDST 125
+ M+ LE + ++ E +L + LK ++ DE +
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALK------------GQFERDLQARDEQNE 1595
Query: 126 TDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQE 185
Q Q+Q+ E ++ ++++ + A + L+ L ++ + + +
Sbjct: 1596 EKRR---------QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 186 KTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNL-ELEKDLRKKAESFAQEMFIEQNK 244
+ E ++Q + L+ + +E+ + + K+ KKA+S ++ Q
Sbjct: 1647 R----EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 245 LKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN-----ETL 299
L Q+ + ++L + L + L++E+ + + ++ +LEE+LE E +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 300 HKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
+ QQ E L + Q +E + L+ EL+ ++++ E +V
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Score = 50.8 bits (120), Expect = 2e-06
Identities = 71/335 (21%), Positives = 147/335 (43%), Gaps = 63/335 (18%)
Query: 6 EEKQLQLITSLK--EQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVI 63
++ +LQ +++K E+AI + L+A+ + + + + R RDE +E +K + +
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Query: 64 EEVNFMQNHLEIEKTCR--------ESAEALATKLNKEN--KTLKRISMLYMAKLGPDVI 113
++ +Q L + R E AE LA+ L+ N + KR +A+L ++
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 114 TEEINID-----------------DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQ- 155
E+ N++ +E +T + Q ++Q KELR ++ ++
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 156 EEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYE 215
K + L++K+ ++ E+V + +EK + ++ K L++ +L VE
Sbjct: 1814 AVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI----LLQVE--- 1866
Query: 216 EMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQ 275
D RK AE + ++ ++K QL + L+E + +Q+
Sbjct: 1867 ----------DERKMAEQYKEQAEKGNARVK--------------QLKRQLEEAEEESQR 1902
Query: 276 LEEERIQHQQKVKELEEQLENETLHKEIHNLKQQL 310
+ R + Q+++ E E NE + +E++ LK +L
Sbjct: 1903 INANRRKLQRELDEATE--SNEAMGREVNALKSKL 1935
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 73.9 bits (180), Expect = 3e-13
Identities = 112/461 (24%), Positives = 187/461 (40%), Gaps = 126/461 (27%)
Query: 11 QLITSLKE--QAIGEYEDLRA---ENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
+L T +K Q + E+++A E QKTKE+ K E L+E ++ + EE
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEE 895
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKL------GPDVITE---- 115
N +Q L+ E AE + +L + + L+ I A+L G + E
Sbjct: 896 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 955
Query: 116 -EINIDDEDSTTDTDGAAE--TCVSVQCQKQIKELRDQIV-------SVQEEKKILAIEL 165
+ +D E+ + + A + V + +IK+L D+I+ + +E+K+L +
Sbjct: 956 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 166 ENLKSKLVEVIEEVN-----KVKQEKTVLNSEVL-----EQRKVLEKCNR---------- 205
+L + L E E+ K K E + EV + R+ LEK R
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 206 ------------VSMLAVEEYEEMQVNL-------------------------ELEKDL- 227
+ M ++ EE+Q L +L++DL
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135
Query: 228 -----RKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ-----------LLKALDENAK 271
R KAE +++ E LK + L S+ Q+ L KALDE +
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 272 LTQ-QLEEERIQHQQKVKELEEQLE------------NETLHKEIHNLKQQLELL----- 313
+ Q++E R +H Q V+EL EQLE +TL KE +L +L +L
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 314 --EEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
E KK+LE + Q + K + + + EL +V++ +N V
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Score = 70.1 bits (170), Expect = 4e-12
Identities = 74/356 (20%), Positives = 156/356 (43%), Gaps = 32/356 (8%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
DE KQ L + K++ G+ +DL + D + R+EA+K+L + Q
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQ-------ADSAIKGREEAIKQLRKLQ-------A 1659
Query: 65 EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKL-GPDVITEEINIDDED 123
++ Q LE + R+ A A + K+ K+L+ M L + ++ +++ E+
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719
Query: 124 STTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVK 183
+ + ++Q +K + L +I ++E ELE + + + + V K
Sbjct: 1720 LAEELASSLSGRNALQDEK--RRLEARIAQLEE-------ELEEEQGNMEAMSDRVRKAT 1770
Query: 184 QEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNL-ELEKDLRKKAESFAQEMFIEQ 242
Q+ L++E+ +R +K + +E++ L E+E ++ K +S + +
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 243 NKLKRQSHLLLQSSIPDQQLLKALDENAK-LTQQLEEERIQHQQKVKELEEQLENETLHK 301
+L+ Q + + LK D+ K + Q+E+ER +Q ++ E+ +
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG------NA 1884
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPP 357
+ LK+QLE EE+ + + + + + S + + + VN ++ + PPP
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940
Score = 66.2 bits (160), Expect = 6e-11
Identities = 92/421 (21%), Positives = 184/421 (43%), Gaps = 75/421 (17%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
N ++EE++ + +T LK + +E + +E + +K +K RQE ++ +KLE H
Sbjct: 1021 NLAEEEEKAKNLTKLKNK----HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1076
Query: 62 VIEEVNFMQNHLEIEKTCRESA-EALATKLNKE----NKTLKRISML--YMAKLGPDVIT 114
I ++ L+++ +E +A +L+ E N LK+I L +++ L D+ +
Sbjct: 1077 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 115 EEI----------NIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSV-----QEEKK 159
E ++ +E T+ +T S Q++++ R+Q V+V EE +
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTE-LEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 160 ILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCN-------RVSMLAVE 212
+++ ++ K + +EE+ + ++ + + + ++ LEK N RV A +
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 213 EYEEMQVNLELE-KDLRKKA---ESFAQEMFIEQNKLKRQSHLL---------------- 252
E E + LE + ++L+ K E E+ + +KL+ + +
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1315
Query: 253 ----LQSSIPDQQLLKALDENAKLT-----QQLEEERIQHQQKVKELEEQLENETLH--- 300
L S + D Q L + KL +QLEEER Q ++ E E +N H
Sbjct: 1316 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 301 ---------KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENS 351
K++ + +E LEE KK + + +N ++ + D+L+K N+ +
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1435
Query: 352 V 352
+
Sbjct: 1436 L 1436
Score = 59.3 bits (142), Expect = 7e-09
Identities = 84/382 (21%), Positives = 158/382 (41%), Gaps = 48/382 (12%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
E Q+Q + QA+ E + + ++ K DK +Q ++ L ++ +EV
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 67 NFMQNHLE-----IEKTCRESAEALATKLNKENKTLKRIS----MLYMA-----KLGPDV 112
+ LE ++ C + A A +K +K + ML A KL DV
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 113 ITEEINIDDEDSTTDTDGAAETCVSV---QCQKQIKELRDQIVSVQEEKK-------ILA 162
+ + D + + VS Q +++ L+DQ+ E K+ L
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 163 IELENLKSKL------VEVIEEVNK-VKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYE 215
I+L + K KL VE +EE K ++E L + E+ +K + +E +
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 216 EMQVNLE----LEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAK 271
++ V+L+ L +L KK F Q + E+N + S D++ + K
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN---------ISSKYADERDRAEAEAREK 1488
Query: 272 LTQQLEEERIQHQQKVKELEEQLE--NETLHKEIHNLKQQLELLEEDKKELELKYQNSEE 329
T+ L R ++ E +E+LE N+ L E+ +L + + ++ ELE + E
Sbjct: 1489 ETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 330 KARNLKHSVDELQKRVNQSENS 351
+ +K ++EL+ + +E++
Sbjct: 1547 QMEEMKTQLEELEDELQATEDA 1568
Score = 59.3 bits (142), Expect = 7e-09
Identities = 64/353 (18%), Positives = 145/353 (41%), Gaps = 32/353 (9%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
E K L L +L E+A+ E+L N+ K + + + +D+ K + E +K + +
Sbjct: 1489 ETKALSLARAL-EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDST 125
+ M+ LE + ++ E +L + LK ++ DE +
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALK------------GQFERDLQARDEQNE 1595
Query: 126 TDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQE 185
Q Q+Q+ E ++ ++++ + A + L+ L ++ + + +
Sbjct: 1596 EKRR---------QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1646
Query: 186 KTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNL-ELEKDLRKKAESFAQEMFIEQNK 244
+ E ++Q + L+ + +E+ + + K+ KKA+S ++ Q
Sbjct: 1647 R----EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702
Query: 245 LKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN-----ETL 299
L Q+ + ++L + L + L++E+ + + ++ +LEE+LE E +
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762
Query: 300 HKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
+ QQ E L + Q +E + L+ EL+ ++++ E +V
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 73.9 bits (180), Expect = 3e-13
Identities = 112/461 (24%), Positives = 187/461 (40%), Gaps = 126/461 (27%)
Query: 11 QLITSLKE--QAIGEYEDLRA---ENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
+L T +K Q + E+++A E QKTKE+ K E L+E ++ + EE
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENE-------LKELEQKHSQLTEE 888
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKL------GPDVITE---- 115
N +Q L+ E AE + +L + + L+ I A+L G + E
Sbjct: 889 KNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKM 948
Query: 116 -EINIDDEDSTTDTDGAAE--TCVSVQCQKQIKELRDQIV-------SVQEEKKILAIEL 165
+ +D E+ + + A + V + +IK+L D+I+ + +E+K+L +
Sbjct: 949 AQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 166 ENLKSKLVEVIEEVN-----KVKQEKTVLNSEVL-----EQRKVLEKCNR---------- 205
+L + L E E+ K K E + EV + R+ LEK R
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 206 ------------VSMLAVEEYEEMQVNL-------------------------ELEKDL- 227
+ M ++ EE+Q L +L++DL
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128
Query: 228 -----RKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ-----------LLKALDENAK 271
R KAE +++ E LK + L S+ Q+ L KALDE +
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 272 LTQ-QLEEERIQHQQKVKELEEQLE------------NETLHKEIHNLKQQLELL----- 313
+ Q++E R +H Q V+EL EQLE +TL KE +L +L +L
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 314 --EEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
E KK+LE + Q + K + + + EL +V++ +N V
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Score = 70.1 bits (170), Expect = 4e-12
Identities = 74/356 (20%), Positives = 156/356 (43%), Gaps = 32/356 (8%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
DE KQ L + K++ G+ +DL + D + R+EA+K+L + Q
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQ-------ADSAIKGREEAIKQLRKLQ-------A 1652
Query: 65 EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKL-GPDVITEEINIDDED 123
++ Q LE + R+ A A + K+ K+L+ M L + ++ +++ E+
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 124 STTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVK 183
+ + ++Q +K + L +I ++E ELE + + + + V K
Sbjct: 1713 LAEELASSLSGRNALQDEK--RRLEARIAQLEE-------ELEEEQGNMEAMSDRVRKAT 1763
Query: 184 QEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNL-ELEKDLRKKAESFAQEMFIEQ 242
Q+ L++E+ +R +K + +E++ L E+E ++ K +S + +
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 243 NKLKRQSHLLLQSSIPDQQLLKALDENAK-LTQQLEEERIQHQQKVKELEEQLENETLHK 301
+L+ Q + + LK D+ K + Q+E+ER +Q ++ E+ +
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG------NA 1877
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPP 357
+ LK+QLE EE+ + + + + + S + + + VN ++ + PPP
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933
Score = 66.2 bits (160), Expect = 6e-11
Identities = 92/421 (21%), Positives = 184/421 (43%), Gaps = 75/421 (17%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
N ++EE++ + +T LK + +E + +E + +K +K RQE ++ +KLE H
Sbjct: 1014 NLAEEEEKAKNLTKLKNK----HESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHE 1069
Query: 62 VIEEVNFMQNHLEIEKTCRESA-EALATKLNKE----NKTLKRISML--YMAKLGPDVIT 114
I ++ L+++ +E +A +L+ E N LK+I L +++ L D+ +
Sbjct: 1070 QIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 115 EEI----------NIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSV-----QEEKK 159
E ++ +E T+ +T S Q++++ R+Q V+V EE +
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTE-LEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 160 ILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCN-------RVSMLAVE 212
+++ ++ K + +EE+ + ++ + + + ++ LEK N RV A +
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 213 EYEEMQVNLELE-KDLRKKA---ESFAQEMFIEQNKLKRQSHLL---------------- 252
E E + LE + ++L+ K E E+ + +KL+ + +
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAK 1308
Query: 253 ----LQSSIPDQQLLKALDENAKLT-----QQLEEERIQHQQKVKELEEQLENETLH--- 300
L S + D Q L + KL +QLEEER Q ++ E E +N H
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 301 ---------KEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENS 351
K++ + +E LEE KK + + +N ++ + D+L+K N+ +
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE 1428
Query: 352 V 352
+
Sbjct: 1429 L 1429
Score = 59.3 bits (142), Expect = 7e-09
Identities = 84/382 (21%), Positives = 158/382 (41%), Gaps = 48/382 (12%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
E Q+Q + QA+ E + + ++ K DK +Q ++ L ++ +EV
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 67 NFMQNHLE-----IEKTCRESAEALATKLNKENKTLKRIS----MLYMA-----KLGPDV 112
+ LE ++ C + A A +K +K + ML A KL DV
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 113 ITEEINIDDEDSTTDTDGAAETCVSV---QCQKQIKELRDQIVSVQEEKK-------ILA 162
+ + D + + VS Q +++ L+DQ+ E K+ L
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 163 IELENLKSKL------VEVIEEVNK-VKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYE 215
I+L + K KL VE +EE K ++E L + E+ +K + +E +
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 216 EMQVNLE----LEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAK 271
++ V+L+ L +L KK F Q + E+N + S D++ + K
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN---------ISSKYADERDRAEAEAREK 1481
Query: 272 LTQQLEEERIQHQQKVKELEEQLE--NETLHKEIHNLKQQLELLEEDKKELELKYQNSEE 329
T+ L R ++ E +E+LE N+ L E+ +L + + ++ ELE + E
Sbjct: 1482 ETKALSLARAL--EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 330 KARNLKHSVDELQKRVNQSENS 351
+ +K ++EL+ + +E++
Sbjct: 1540 QMEEMKTQLEELEDELQATEDA 1561
Score = 59.3 bits (142), Expect = 7e-09
Identities = 64/353 (18%), Positives = 145/353 (41%), Gaps = 32/353 (9%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
E K L L +L E+A+ E+L N+ K + + + +D+ K + E +K + +
Sbjct: 1482 ETKALSLARAL-EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDST 125
+ M+ LE + ++ E +L + LK ++ DE +
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALK------------GQFERDLQARDEQNE 1588
Query: 126 TDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQE 185
Q Q+Q+ E ++ ++++ + A + L+ L ++ + + +
Sbjct: 1589 EKRR---------QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG 1639
Query: 186 KTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNL-ELEKDLRKKAESFAQEMFIEQNK 244
+ E ++Q + L+ + +E+ + + K+ KKA+S ++ Q
Sbjct: 1640 R----EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695
Query: 245 LKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLEN-----ETL 299
L Q+ + ++L + L + L++E+ + + ++ +LEE+LE E +
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755
Query: 300 HKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
+ QQ E L + Q +E + L+ EL+ ++++ E +V
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 72.8 bits (177), Expect = 6e-13
Identities = 96/450 (21%), Positives = 194/450 (43%), Gaps = 58/450 (12%)
Query: 23 EYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRES 82
E +++ E +KTKE+ K +R E +K+ V MQ +++ +
Sbjct: 852 EMANMKEEFEKTKEELAKTEAKRKELEEKM-------------VTLMQEKNDLQLQVQAE 898
Query: 83 AEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN--IDDEDSTTDTDGAAETCVSVQC 140
A++LA +R L K+ + +E+ +DE+ A + + +C
Sbjct: 899 ADSLAD-------AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951
Query: 141 ---QKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVL---NSEVL 194
+K I +L + V++EK +++NL ++ + E + K+ +EK L + + L
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 195 EQRKVLE-KCNRVSMLAV---EEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSH 250
+ + E K N ++ + ++ ++++ +LE EK +R M +E+ K K +
Sbjct: 1012 DDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIR---------MDLERAKRKLEGD 1062
Query: 251 L-LLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENET-----LHKEIH 304
L L Q S D EN K QQL+E+ + + ++ L+ ++E+E L K+I
Sbjct: 1063 LKLAQESTMDI-------ENDK--QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIK 1113
Query: 305 NLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPP 364
L+ ++E LEE+ + +E++ +L ++E+ +R+ ++ +
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1173
Query: 365 PPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKR--QAVEEMMDRIKKGVH 422
R L + + + KK + E E++ +L+R Q +E+ +K +
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1233
Query: 423 LRPVNQTARPKTKPESSKGCESAVDELKGI 452
N K K K C + D+L I
Sbjct: 1234 DLASNMETVSKAKGNLEKMCRALEDQLSEI 1263
Score = 60.8 bits (146), Expect = 2e-09
Identities = 70/396 (17%), Positives = 168/396 (42%), Gaps = 59/396 (14%)
Query: 9 QLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNF 68
+L I + E+++ + E L+ EN+ +++ + ++ E K++ E +KI V +E +
Sbjct: 1484 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSE 1543
Query: 69 MQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN----IDDEDS 124
+Q LE + E E ++ E +K +A+ ++ + N ++ S
Sbjct: 1544 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQS 1603
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLV----------- 173
T D + + +K +L + + + ++ A L N ++
Sbjct: 1604 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDD 1663
Query: 174 ------EVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDL 227
++ E++ V++ +L +E+ E R LE+ R +A +E + ++L
Sbjct: 1664 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1723
Query: 228 RKKAESFAQEMFIEQNKLKRQSHLLLQSSI-PDQQLLKALDENAKLTQQLEEER------ 280
+ +++ + ++++ + ++Q + +++ KA+ + A + ++L++E+
Sbjct: 1724 NTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1783
Query: 281 -------------IQHQ----------------QKVKELEEQLENETLHKEIHNLKQQLE 311
+QH+ QK++ +LE E ++ N++
Sbjct: 1784 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKG 1843
Query: 312 LLEEDKKELELKYQNSEEKAR--NLKHSVDELQKRV 345
L + ++K EL YQ E++ L+ VD+LQ +V
Sbjct: 1844 LRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKV 1879
Score = 56.2 bits (134), Expect = 6e-08
Identities = 72/386 (18%), Positives = 161/386 (41%), Gaps = 47/386 (12%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
+K + L EQ ++L+ QK +++ +++ E D+ +E K + +
Sbjct: 1198 KKHADSVAELGEQI----DNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMC 1253
Query: 67 NFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGP-DVITEEIN------- 118
+++ L KT E + L L + L+ S Y +L D + +++
Sbjct: 1254 RALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFT 1313
Query: 119 --IDDEDSTTDTDGAAETCVSVQCQKQIKE---LRDQIVSVQEEKKILAIELENLKSKLV 173
I++ + + A++ ++ Q + LR+Q QE K L + S++
Sbjct: 1314 QQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVA 1373
Query: 174 E--------VIEEVNKVKQEKTVLNSEVLEQRKVLEKCN-------RVSMLAVEEYEEMQ 218
+ I+ ++++ K L + + + +E N + E E++
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1433
Query: 219 VNLELEKD----LRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLK--------AL 266
+++E L KK +F ++ E + ++H L++S + + L A
Sbjct: 1434 IDVERTNAACAALDKKQRNF-DKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAY 1492
Query: 267 DENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQN 326
+E+ + L+ E QQ++ +L EQ+ K IH L++ + +E++K EL+ +
Sbjct: 1493 EESLDQLETLKRENKNLQQEISDLTEQIAEGG--KRIHELEKIKKQVEQEKSELQAALEE 1550
Query: 327 SEEKARNLKHSVDELQKRVNQSENSV 352
+E + + + +Q +NQ ++ V
Sbjct: 1551 AEASLEHEEGKILRIQLELNQVKSEV 1576
Score = 51.6 bits (122), Expect = 1e-06
Identities = 73/350 (20%), Positives = 141/350 (40%), Gaps = 62/350 (17%)
Query: 4 SDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVI 63
SD ++L+ I+ E+A G N+K + + K+R++ +EA +
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ------------ 1188
Query: 64 EEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDED 123
H T R+ +L ++ L+R+ KL + ++ IDD
Sbjct: 1189 --------HEATAATLRKKHADSVAELGEQIDNLQRVKQ----KLEKEKSEMKMEIDDLA 1236
Query: 124 STTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVK 183
S +T A+ + C + +++ +I + +EE++ L +L +++L E ++
Sbjct: 1237 SNMETVSKAKGNLEKMC-RALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQL 1295
Query: 184 QEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQN 243
EK L S++ +R ++ EE++ LE E+
Sbjct: 1296 DEKDTLVSQL----------SRGKQAFTQQIEELKRQLE------------------EEI 1327
Query: 244 KLKRQSHLLLQSSIPDQQLLK-ALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKE 302
K K LQSS D LL+ +E + +L+ + +V + + E + +
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAI--- 1384
Query: 303 IHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
Q+ E LEE KK+L + Q++EE + L+K + +N V
Sbjct: 1385 -----QRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEV 1429
Score = 49.3 bits (116), Expect = 7e-06
Identities = 60/319 (18%), Positives = 142/319 (44%), Gaps = 44/319 (13%)
Query: 137 SVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQ 196
S + +K++ ++++ +EE + + L+ K+V +++E N ++ + + +E
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ---VQAEADSL 902
Query: 197 RKVLEKCN-----------RVSMLAVEEYEEMQVNLELEKDLRKKAESFAQ------EMF 239
E+C+ ++ + +E ++N EL RK + ++ ++
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962
Query: 240 IEQNKLKRQSHLLLQSSIPDQQLLKALDEN-AKLTQQLEEERIQHQQKVKELE-EQLENE 297
+ K++++ H + + LDE AKLT++ + + HQQ + +L+ E+ +
Sbjct: 963 LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN 1022
Query: 298 TLHKEIHNLKQQLELLE---EDKKELELKYQNSEEK--------------ARNLKHSVDE 340
TL K L+QQ++ LE E +K++ + + ++ K N K +DE
Sbjct: 1023 TLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDE 1082
Query: 341 LQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTE 400
K+ + + L I+ L + I + + E+A++ + +
Sbjct: 1083 KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE----IEAERASRAKAEK 1138
Query: 401 EVTDLKRQAVEEMMDRIKK 419
+ +DL R+ +EE+ +R+++
Sbjct: 1139 QRSDLSRE-LEEISERLEE 1156
Score = 35.4 bits (80), Expect = 0.11
Identities = 35/167 (20%), Positives = 69/167 (41%), Gaps = 16/167 (9%)
Query: 286 KVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345
K+K L + E E KE+ N+K++ E +E+ + E K + EEK L ++LQ +V
Sbjct: 839 KIKPLLKSAETE---KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV 895
Query: 346 NQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDL 405
+S+ L I++ + + K + E+A E
Sbjct: 896 QAEADSLADAEERCDQL-------IKTKIQLEAKIKEVT------ERAEDEEEINAELTA 942
Query: 406 KRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELKGI 452
K++ +E+ +KK + + K K + ++ +E+ G+
Sbjct: 943 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 989
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 72.4 bits (176), Expect = 8e-13
Identities = 97/411 (23%), Positives = 184/411 (44%), Gaps = 78/411 (18%)
Query: 9 QLQL-ITSLKEQAIGEYEDLRA---ENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
QL+L + S++EQ I L+ E Q+ + ++++Q ++ K++E Q + +
Sbjct: 928 QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987
Query: 65 EVNFMQNHLEIEKTC--------RESAEALATKLNKENKTLKRI--------SMLYMAKL 108
+ ++N L+ + T +E L K +T K++ S L +
Sbjct: 988 QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047
Query: 109 GPDVITEEINIDDEDSTTD---------------TDGAAETCVSVQCQKQIKELRDQIVS 153
+ E++++ ED ++ T A S + ++Q++E +
Sbjct: 1048 DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD 1107
Query: 154 VQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTV------LNSEVLEQRKVLEKCNRVS 207
+Q+EK + EL N KSKL E IEE+ K +QEK + L S LE K +
Sbjct: 1108 IQKEKSLKEKELVNEKSKLAE-IEEI-KCRQEKEITKLNEELKSHKLESIKEITNLKDAK 1165
Query: 208 MLAVEEYEEMQ--------------VNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLL 253
L +++ E+Q N ++ KD KK E ++ FIE+ L
Sbjct: 1166 QLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEK-------EAKL 1218
Query: 254 QSSIPDQQL-LKALDEN-AKLTQQL----------EEERIQHQQKVKELEEQLENETLHK 301
S I ++++ +K +EN AKLT Q+ ++E Q++V ELE+Q ++ L
Sbjct: 1219 HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD--LRG 1276
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
EI L+ ++ +++++ L + E + L+ V ELQ++++ + +V
Sbjct: 1277 EIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327
Score = 66.2 bits (160), Expect = 6e-11
Identities = 76/374 (20%), Positives = 172/374 (45%), Gaps = 34/374 (9%)
Query: 3 SSDEEKQLQLITSLKEQAI---GEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKIS 59
S + +K+L+ L++Q G D AE Q +++ ++ + E + + F++ +
Sbjct: 106 SEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKA 165
Query: 60 HMVIEEVNFMQNHLEIEKTCRESAEALATK----LNKENKTLKRISMLYMAKLG-PDVIT 114
+ E+ +++ + E++ RE+AE T+ LNKE ++ + + + G DV
Sbjct: 166 AQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAV 225
Query: 115 EEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVE 174
+ + + D ++++ +++ ++L+D+ +Q + + L+S+L +
Sbjct: 226 LKKELVQVQTLMDN-------MTLERERESEKLKDECKKLQSQYASSEATISQLRSELAK 278
Query: 175 VIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESF 234
+EV QE L S V E + + + ++Y +++ E +K ++
Sbjct: 279 GPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAT 338
Query: 235 AQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELE--- 291
+ ++ +L+ + L S ++ L E + TQ+L+EE + + K + L+
Sbjct: 339 LHQKDLDCQQLQSR---LSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF 395
Query: 292 EQLENETLHKEIHNLKQQLE-------LLEEDKK------ELELKYQNSEEKARNLKHSV 338
+QL+ + KE H L+ Q E LLE +++ L+ + Q S EK + + V
Sbjct: 396 KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQV 455
Query: 339 DELQKRVNQSENSV 352
+LQ ++++ E +
Sbjct: 456 ADLQLKLSRLEEQL 469
Score = 58.5 bits (140), Expect = 1e-08
Identities = 84/370 (22%), Positives = 164/370 (44%), Gaps = 47/370 (12%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAEN----------QKTKEKCDKIRQE--RDEAVKKL 52
D ++Q QL T L+ +A + L E QK E + I+Q+ + E K++
Sbjct: 752 DLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQI 811
Query: 53 --EEFQKISHMVIEEVNFMQNHL-----EIEKTCRESAEALATKLNKENKTLKRIS-MLY 104
++F+ +S + + N + E++K E EAL T+L+ L ++S L
Sbjct: 812 LKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEK-EALMTELSTVKDKLSKVSDSLK 870
Query: 105 MAKLGPDVITEEINIDDEDSTTDTDGAAETC------VSVQCQKQIKELRDQIVSVQEEK 158
+K E +++ +TC + VQ + +KE ++ S+++EK
Sbjct: 871 NSK-------SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
Query: 159 KI---LAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLE-KCNRVSMLAVEEY 214
+ L +EL +++ +L++ + + ++E+ L + E ++ E K ++ L E
Sbjct: 924 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Query: 215 EEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQ 274
+ ELE L+++ AQE+ E+ K+ +L + Q+ K L +
Sbjct: 984 IAVLQKTELENKLQQQLTQAAQELAAEKEKIS----VLQNNYEKSQETFKQLQSD---FY 1036
Query: 275 QLEEERIQHQQKVKELEEQLE--NETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKAR 332
E E + +Q +K +EE+L E L + + Q +L++E K Q+S +K +
Sbjct: 1037 GRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQ 1096
Query: 333 NLKHSVDELQ 342
L+ LQ
Sbjct: 1097 QLQERCKALQ 1106
Score = 55.5 bits (132), Expect = 1e-07
Identities = 72/385 (18%), Positives = 170/385 (44%), Gaps = 41/385 (10%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
N + +E+ QL LK Q+ + + + +E+ +R +D + +++
Sbjct: 570 NHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQ 629
Query: 62 VIE-EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
+ E + Q ++I+ A A K + + A +I
Sbjct: 630 LNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEV----- 175
+ T E C Q + +KE +++ +S++++ + L +++ L++ +EV
Sbjct: 690 LDQVTAKLQDKQEHCS--QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE 747
Query: 176 --IEEVNKVKQEKTVLN------SEVLEQRKVLEKCNRVSML----AVEEYEEMQVNLEL 223
++++ + +Q T L S+ LE K + R+ + A+E ++ E
Sbjct: 748 QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE 807
Query: 224 EKDLRKKA-ESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQ--QLEEER 280
EK + K+ E+ +QE I+ +L + +Q+++ + Q +K +++ A +T+ ++++
Sbjct: 808 EKQILKQDFETLSQETKIQHEELNNR----IQTTVTELQKVK-MEKEALMTELSTVKDKL 862
Query: 281 IQHQQKVKELEEQLENET---------LHKEIHNLKQQLELLEE----DKKELELKYQNS 327
+ +K + + E E L K LK QL++ E ++KEL+ +
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
Query: 328 EEKARNLKHSVDELQKRVNQSENSV 352
+E + LK ++ +Q+++ Q++N++
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTL 947
Score = 52.0 bits (123), Expect = 1e-06
Identities = 79/384 (20%), Positives = 162/384 (42%), Gaps = 57/384 (14%)
Query: 16 LKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKL-EEFQKI-SHMVIEEVNFMQNHL 73
L+ I + L+ E + + D + ER+ +KL +E +K+ S E Q
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRS 274
Query: 74 EIEKTCRESA---------EALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDS 124
E+ K +E A ++ +L ++N+TL + K D E ++E
Sbjct: 275 ELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE----NLLKKEQDYTKLEEKHNEESV 330
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQ 184
+ A + CQ +L+ ++ + + + +EL ++ EE+++V+
Sbjct: 331 SKKNIQATLHQKDLDCQ----QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVET 386
Query: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNL-ELEKDLRKKAESFAQEMFIEQN 243
+ L +E + ++ E+ + + E ++ L E E+ L + ++ +
Sbjct: 387 KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE 446
Query: 244 KL----KRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQ----------KVKE 289
KL ++ + L L+ S ++QL + + + +L QL++ + QHQ+ K++E
Sbjct: 447 KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
Query: 290 LEEQLEN------------ETLHKEIHNLKQQLELLEEDKKELELKYQNSE--------- 328
+ LE + L + K+ + LLE+++++L K Q E
Sbjct: 507 AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL 566
Query: 329 -EKARNLKHSVDEL-QKRVNQSEN 350
EK L+ V +L +K NQSE+
Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSES 590
Score = 50.8 bits (120), Expect = 2e-06
Identities = 72/329 (21%), Positives = 144/329 (43%), Gaps = 47/329 (14%)
Query: 32 QKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLN 91
Q +++ +KI + D+ KL++ Q E + +++HL+ K S E +L
Sbjct: 677 QDKQQELNKITTQLDQVTAKLQDKQ-------EHCSQLESHLKEYKEKYLSLEQKTEELE 729
Query: 92 KENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQI 151
+ K L+ S+ K + +++ TD + A + KQ++ ++ +
Sbjct: 730 GQIKKLEADSL--EVKASKEQALQDLQ-QQRQLNTDLELRA-----TELSKQLEMEKEIV 781
Query: 152 VSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAV 211
S + + + + LE++K KL + EE +KQ+ L+ E Q + L NR+
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELN--NRIQTTVT 839
Query: 212 EEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAK 271
E L+K ++ + E+ E+ ++KL + S L S E K
Sbjct: 840 E----------LQK-VKMEKEALMTELSTVKDKLSKVSDSLKNSK----------SEFEK 878
Query: 272 LTQQLEEERIQHQQKVKELEEQLE--NETLHKEIHNLKQQLELLEEDKKELELKYQNSEE 329
Q+ + + ++ KEL+ QL+ E KE LK+ LE +E +L+L+ + +E
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQE 938
Query: 330 KARNLKHSV-------DELQKRVNQSENS 351
+ ++++ +LQ +N+ + S
Sbjct: 939 QLIQAQNTLKQNEKEEQQLQGNINELKQS 967
Score = 41.2 bits (95), Expect = 0.002
Identities = 59/310 (19%), Positives = 132/310 (42%), Gaps = 44/310 (14%)
Query: 25 EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAE 84
+ L+ E + + K ++ E + ++ EE ++ + E+N Q H ++ +T R+ E
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN--QLHSKLLETERQLGE 432
Query: 85 ALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQI 144
A KE + L ++ + D+ + ++++ T+ S + Q Q+
Sbjct: 433 AHGRL--KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN-------STELQHQL 483
Query: 145 KELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCN 204
+ + Q Q ++ +L ++ L +V+ ++ Q+ + N E L Q+
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK--IQNLEALLQKSK----E 537
Query: 205 RVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLK 264
+S+L E +DL K ++ E + N+L+ ++H L
Sbjct: 538 NISLLEKER-----------EDLYAKIQAGEGETAV-LNQLQEKNHTL------------ 573
Query: 265 ALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKY 324
++ +LT++L+ + H+Q + L +Q++ + H + + ++ LE EL +
Sbjct: 574 -QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH--LRAAQDRVLSLETSVNELNSQL 630
Query: 325 QNSEEKARNL 334
S+EK L
Sbjct: 631 NESKEKVSQL 640
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 72.4 bits (176), Expect = 8e-13
Identities = 80/371 (21%), Positives = 168/371 (45%), Gaps = 45/371 (12%)
Query: 2 NSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
N E +++ +T E+ +L A+ +K +++C +++++ D+ L + +K H
Sbjct: 914 NKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA 973
Query: 62 VIEEV-NFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
+V N + +++T KL+KE K L+ + L + +++NI
Sbjct: 974 TENKVKNLTEEMAGLDETI--------AKLSKEKKALQETHQQTLDDLQAE--EDKVNIL 1023
Query: 121 D------EDSTTDTDGAAET--CVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKL 172
E D +G+ E + + ++ ++L + QE +++EN K +L
Sbjct: 1024 TKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES----TMDMENDKQQL 1079
Query: 173 VEVIEE--------VNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELE 224
E +E+ ++K++ E+ V E+ Q+K+ E R+ EE+ +E E
Sbjct: 1080 DEKLEKKEFEISNLISKIEDEQAV---EIQLQKKIKELQARI--------EELGEEIEAE 1128
Query: 225 KDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALD-ENAKLTQQLEEERIQH 283
+ R KAE ++ E ++ + ++ +L K + E KL + LEE +QH
Sbjct: 1129 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQH 1188
Query: 284 QQKVKELEEQLENET--LHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDEL 341
+ V L ++ + L ++I NL++ + LE++K EL+++ + A + + L
Sbjct: 1189 EAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNL 1248
Query: 342 QKRVNQSENSV 352
+K E+ V
Sbjct: 1249 EKMCRSLEDQV 1259
Score = 62.0 bits (149), Expect = 1e-09
Identities = 86/367 (23%), Positives = 155/367 (42%), Gaps = 47/367 (12%)
Query: 3 SSDEEKQLQL-ITSLKEQAIGEYE-------DLRAENQKTKEKCDKIRQERDEAVKKLEE 54
S ++EK+L++ + K + G+ + D+ + Q+ EK +K E + K+E+
Sbjct: 1040 SLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIED 1099
Query: 55 FQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVIT 114
Q + + +++ +Q +E E+ A K K+ L R
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRE-------------L 1146
Query: 115 EEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQI--VSVQEEKKILAIELENLKS-- 170
EEI+ E++ T E ++ + + + ++LR + ++Q E + A+ ++ S
Sbjct: 1147 EEISERLEEAGGATSAQVE--LNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMA 1204
Query: 171 KLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKK 230
+L E I+ + +VKQ+ SE+ + L A E+M +LE + K
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264
Query: 231 AESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKEL 290
E Q + N L Q L + + + LDE L QL + Q+++EL
Sbjct: 1265 KEEEQQRLI---NDLTAQRARLQTEA---GEYSRQLDEKDALVSQLSRSKQASTQQIEEL 1318
Query: 291 EEQLENET---------LHKEIHN---LKQQLELLEEDKKELE--LKYQNSEEKARNLKH 336
+ QLE ET L H+ L++Q E +E K EL+ L NSE K+
Sbjct: 1319 KHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY 1378
Query: 337 SVDELQK 343
D +Q+
Sbjct: 1379 ETDAIQR 1385
Score = 61.6 bits (148), Expect = 1e-09
Identities = 84/365 (23%), Positives = 168/365 (46%), Gaps = 48/365 (13%)
Query: 6 EEKQLQLITSLKE-QAIGEYED-----LRAENQKTKEKCDKIRQERDEAVKKLEEFQKIS 59
E+++ ++ +L+E +A E+E+ ++ E + K + D+ E+DE + +L K +
Sbjct: 1537 EQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL----KRN 1592
Query: 60 HMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINI 119
H + E MQ+ L+ E R A + K+ + ++ I + + +L + + N
Sbjct: 1593 HTRVVET--MQSTLDAEIRSRNDALRVKKKMEGDLNEME-IQLNHANRLAAESLRNYRNT 1649
Query: 120 DD--EDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIE 177
+++ D A + ++L++Q+ V+ +L E+E L + L E E
Sbjct: 1650 QGILKETQLHLDDAL---------RGQEDLKEQLAIVERRANLLQAEIEELWATL-EQTE 1699
Query: 178 EVNKVKQEKTV-----------LNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKD 226
K+ +++ + N+ ++ +K LE N VS L E E +Q + E+
Sbjct: 1700 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLE--NDVSQLQSEVEEVIQESRNAEEK 1757
Query: 227 LRKK---AESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQH 283
+K A A+E+ EQ+ + + L LDE +L + +++IQ
Sbjct: 1758 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1817
Query: 284 -QQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKAR--NLKHSVDE 340
+ +V+ELE ++ENE + N + L + +++ EL YQ E++ L+ VD+
Sbjct: 1818 LEARVRELEGEVENE----QKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDK 1873
Query: 341 LQKRV 345
LQ +V
Sbjct: 1874 LQAKV 1878
Score = 60.8 bits (146), Expect = 2e-09
Identities = 74/378 (19%), Positives = 160/378 (42%), Gaps = 47/378 (12%)
Query: 9 QLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNF 68
+L + ++ E+++ + E LR EN+ +++ + ++ E K++ E +KI V +E
Sbjct: 1483 ELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCE 1542
Query: 69 MQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN----IDDEDS 124
+Q LE + E E ++ E +K +A+ ++ + N ++ S
Sbjct: 1543 IQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQS 1602
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIEL------------------- 165
T D + + +K +L + + + ++ A L
Sbjct: 1603 TLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDD 1662
Query: 166 -----ENLKSKLVEVIEEVNKVKQEKTVL--------NSEVLEQRKVLEKCNRVSMLAVE 212
E+LK +L V N ++ E L S + ++++L+ RV +L +
Sbjct: 1663 ALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQ 1722
Query: 213 EYEEMQVNLELEKD---LRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDEN 269
+ +LE D L+ + E QE + K K+ + +++ ++L K D +
Sbjct: 1723 NTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKK---AITDAAMMAEELKKEQDTS 1779
Query: 270 AKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEE 329
A LE + +Q VK+L+ +L+ E + K+Q++ LE +ELE + +N ++
Sbjct: 1780 A----HLERMKKNLEQTVKDLQHRLD-EAEQLALKGGKKQIQKLEARVRELEGEVENEQK 1834
Query: 330 KARNLKHSVDELQKRVNQ 347
+ + + ++RV +
Sbjct: 1835 RNAEAVKGLRKHERRVKE 1852
Score = 55.1 bits (131), Expect = 1e-07
Identities = 74/365 (20%), Positives = 152/365 (41%), Gaps = 63/365 (17%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE-- 64
+K+++ + + E+ E E RA K +++ + +E +E ++LEE + +E
Sbjct: 1108 QKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELN 1167
Query: 65 ---EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDV-----ITEE 116
E F + ++E+ + EA+ L K++ MA+LG + + ++
Sbjct: 1168 KKREAEFQKLRRDLEEATLQH-EAMVAALRKKHADS-------MAELGEQIDNLQRVKQK 1219
Query: 117 INIDDEDSTTDTDGAAETCVSVQ-----CQKQIKELRDQIVSV---QEEKKILAIELENL 168
+ + + +TD + ++ +K + L DQ+ + +EE++ L +L
Sbjct: 1220 LEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQ 1279
Query: 169 KSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLR 228
+++L E ++ EK L S++ +R + ++ EE++ LE
Sbjct: 1280 RARLQTEAGEYSRQLDEKDALVSQL----------SRSKQASTQQIEELKHQLE------ 1323
Query: 229 KKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKA-LDENAKLTQQLEEERIQHQQKV 287
E+ K K LQSS D LL+ +E + +L+ + +V
Sbjct: 1324 ------------EETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEV 1371
Query: 288 KELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ 347
+ + E + + Q+ E LEE KK+L + Q +EE + L+K +
Sbjct: 1372 AQWRTKYETDAI--------QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQR 1423
Query: 348 SENSV 352
+N V
Sbjct: 1424 LQNEV 1428
Score = 54.3 bits (129), Expect = 2e-07
Identities = 62/302 (20%), Positives = 142/302 (47%), Gaps = 47/302 (15%)
Query: 145 KELRDQIVSVQEEKKILAIELENLKSKLVEV-----------------IEEVNKVKQEKT 187
KEL +++V++ +EK L +++++ L + I+EV + +E+
Sbjct: 874 KELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEE 933
Query: 188 VLNSEV-LEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKD-LRKKAESFAQEMF-IEQN- 243
+N+E+ ++RK+ ++C+ + +++ E +E EK K ++ +EM +++
Sbjct: 934 EINAELTAKKRKLEDECSELKK-DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 992
Query: 244 -KLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENE-TLHK 301
KL ++ L ++ QQ L L L + + + +Q+V +LE LE E L
Sbjct: 993 AKLSKEKKALQET---HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRM 1049
Query: 302 EIHNLKQQLE----LLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPP 357
++ K++LE L +E ++E Q +EK + + L ++ + E +V
Sbjct: 1050 DLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKI-EDEQAV----- 1103
Query: 358 PPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRI 417
++ + ++ R G + E+A++ + ++ +DL R+ +EE+ +R+
Sbjct: 1104 ---------EIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRE-LEEISERL 1153
Query: 418 KK 419
++
Sbjct: 1154 EE 1155
Score = 52.8 bits (125), Expect = 7e-07
Identities = 79/364 (21%), Positives = 150/364 (41%), Gaps = 71/364 (19%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
EE+Q +LI L Q RA Q + + E+D V +L ++ S IEE
Sbjct: 1266 EEEQQRLINDLTAQ--------RARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEE 1317
Query: 66 VNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDST 125
+++ LE E+T ++A A A + ++ + L R E ++++
Sbjct: 1318 ---LKHQLE-EETKAKNALAHALQSSRHDCDLLR----------------EQYEEEQEGK 1357
Query: 126 TDTDGAAETCVSVQCQKQIKELRDQIV---SVQEEKKILAIELENLKSKLVEVIEEVNKV 182
+ A S Q + K D I ++E KK LA L+ + + V + +
Sbjct: 1358 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASL 1417
Query: 183 KQEKTVLNSEVLEQRKVLEKCN--------------RVSMLAVEEYEEMQVNLELEKDLR 228
++ K L +EV + +E+ N +V ++YEE Q LE +
Sbjct: 1418 EKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQ--- 1474
Query: 229 KKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVK 288
K++ S + E+F +N +E+ + L E QQ++
Sbjct: 1475 KESRSLSTELFKVKN---------------------VYEESLDQLETLRRENKNLQQEIS 1513
Query: 289 ELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQS 348
+L EQ+ K+IH L++ + +E++K E++ + +E + + + +Q +NQ
Sbjct: 1514 DLTEQIAEGG--KQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQV 1571
Query: 349 ENSV 352
++ V
Sbjct: 1572 KSEV 1575
Score = 46.6 bits (109), Expect = 5e-05
Identities = 39/216 (18%), Positives = 103/216 (47%), Gaps = 19/216 (8%)
Query: 137 SVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQ 196
S + +K++ ++++ ++E + + L+ K+V +++E N ++ + + SE
Sbjct: 845 SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ---VQSEADSL 901
Query: 197 RKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSS 256
E+C ++ ++ +++ ++ + ++ E E+ ++ KL+ +
Sbjct: 902 ADAEERCEQL----IKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDEC------- 950
Query: 257 IPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEED 316
+L K +D+ ++E+E+ + KVK L E++ L + I L ++ + L+E
Sbjct: 951 ---SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--LDETIAKLSKEKKALQET 1005
Query: 317 KKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
++ Q E+K L + +L+++V+ E S+
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSL 1041
Score = 30.8 bits (68), Expect = 2.7
Identities = 32/167 (19%), Positives = 69/167 (41%), Gaps = 16/167 (9%)
Query: 286 KVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345
K+K L + E E KE+ +K++ + +++ + E K + EEK L ++LQ +V
Sbjct: 838 KIKPLLKSAETE---KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQV 894
Query: 346 NQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDL 405
+S+ L I++ + + K + E+A + E
Sbjct: 895 QSEADSLADAEERCEQL-------IKNKIQLEAKIKEVT------ERAEEEEEINAELTA 941
Query: 406 KRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELKGI 452
K++ +E+ +KK + + K K + ++ +E+ G+
Sbjct: 942 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 988
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 72.0 bits (175), Expect = 1e-12
Identities = 97/450 (21%), Positives = 192/450 (42%), Gaps = 58/450 (12%)
Query: 23 EYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRES 82
E +++ E +KTKE+ K +R E +K+ V MQ +++ +
Sbjct: 852 EMANMKEEFEKTKEELAKTEAKRKELEEKM-------------VTLMQEKNDLQLQVQAE 898
Query: 83 AEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN--IDDEDSTTDTDGAAETCVSVQC 140
A+ALA +R L K+ + +E+ +DE+ A + + +C
Sbjct: 899 ADALAD-------AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 951
Query: 141 ---QKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVL---NSEVL 194
+K I +L + V++EK +++NL ++ + E + K+ +EK L + + L
Sbjct: 952 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTL 1011
Query: 195 EQRKVLE-KCNRVSMLAV---EEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSH 250
+ ++ E K N ++ ++ ++++ +LE EK L M +E+ K K +
Sbjct: 1012 DDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLC---------MDLERAKRKLEGD 1062
Query: 251 L-LLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENET-----LHKEIH 304
L L Q S D EN K QQL E+ + + ++ L+ ++E+E L K+I
Sbjct: 1063 LKLAQESTMDT-------ENDK--QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIK 1113
Query: 305 NLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPP 364
L+ ++E LEE+ + +E++ +L ++E+ +R+ ++ +
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1173
Query: 365 PPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDLKR--QAVEEMMDRIKKGVH 422
R L + + + KK + E E++ L+R Q +E+ +K ++
Sbjct: 1174 EFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIN 1233
Query: 423 LRPVNQTARPKTKPESSKGCESAVDELKGI 452
N K K K C + D+L I
Sbjct: 1234 DLASNMETVSKAKANFEKMCRTLEDQLSEI 1263
Score = 61.2 bits (147), Expect = 2e-09
Identities = 87/376 (23%), Positives = 171/376 (45%), Gaps = 69/376 (18%)
Query: 5 DEEKQLQLITSLKE-QAIGEYED-----LRAENQKTKEKCDKIRQERDEAVKKLEEFQKI 58
D EK +L TSL+E +A E+E+ ++ E + K + D+ E+DE + +L K
Sbjct: 1538 DHEKS-ELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQL----KR 1592
Query: 59 SHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN 118
+H+ + V MQ+ L+ E R A + K+ + ++ I + + + + + N
Sbjct: 1593 NHLRV--VESMQSTLDAEIRSRNDALRIKKKMEGDLNEME-IQLNHANRQAAEALRNLRN 1649
Query: 119 IDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEE 178
+ DT + + Q +L++Q+ V+ ++ E+E L++ L
Sbjct: 1650 T--QGILKDTQLHLDDAIRGQ-----DDLKEQLAMVERRANLMQAEVEELRASL------ 1696
Query: 179 VNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRK---KAESFA 235
E+T ++ EQ ++L+ RV +L + + +LE D+ + + E
Sbjct: 1697 ------ERTERGRKMAEQ-ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIV 1749
Query: 236 QEMFIEQNKLKR------------------QSHLL-----LQSSIPDQQLLKALDENAKL 272
QE + K K+ +HL ++ ++ D QL LDE +L
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQL--RLDEAEQL 1807
Query: 273 TQQLEEERIQH-QQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKA 331
+ +++IQ + +V+ELE ++E+E + HN++ L + +++ EL YQ E++
Sbjct: 1808 ALKGGKKQIQKLEARVRELESEVESE----QKHNVEAVKGLRKHERRVKELTYQTEEDRK 1863
Query: 332 R--NLKHSVDELQKRV 345
L+ VD+LQ +V
Sbjct: 1864 NILRLQDLVDKLQTKV 1879
Score = 53.5 bits (127), Expect = 4e-07
Identities = 86/402 (21%), Positives = 165/402 (41%), Gaps = 63/402 (15%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
MN E + ++ L+E + A +K + ++ ++ D + ++ +K
Sbjct: 1167 MNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKS 1226
Query: 61 MVIEEVNFMQNHLE--------IEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDV 112
+ E+N + +++E EK CR + L+ KE + + I+ L K
Sbjct: 1227 ELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHT 1286
Query: 113 ITEEIN--IDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKS 170
+ E + +D++D+ + + +QI+EL+ Q+ + K LA L++ +
Sbjct: 1287 ESGEFSRQLDEKDAMVSQLSRGKQAFT----QQIEELKRQLEEETKAKSTLAHALQSARH 1342
Query: 171 K---LVEVIEEVNKVKQE----KTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLEL 223
L E EE + K E + NSEV + R E A++ EE++ E
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETD------AIQRTEELE---EA 1393
Query: 224 EKDLRKKAESFAQEMFIEQNKLK--RQSHLLLQSSIPDQQL--------LKALDEN---- 269
+K L ++ + + + +K ++ LQ+ + D + ALD+
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNF 1453
Query: 270 ----AKLTQQLEEERIQHQQKVKE--------------LEEQLEN-ETLHKEIHNLKQQL 310
A+ Q+ EE + + + KE EE L++ ETL +E NL+Q++
Sbjct: 1454 DKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEI 1513
Query: 311 ELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
L E E E+ + L H ELQ + ++E S+
Sbjct: 1514 SDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL 1555
Score = 53.1 bits (126), Expect = 5e-07
Identities = 72/355 (20%), Positives = 147/355 (41%), Gaps = 56/355 (15%)
Query: 16 LKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQK-ISHMVIEEVNFMQNHLE 74
L E E E R N+ + +K ++ E E ++L+E +S + + F Q E
Sbjct: 1260 LSEIKTKEEEQQRLINELSAQKA-RLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEE 1318
Query: 75 IEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAET 134
+++ E +A +T + L A+ D++ E+ +++++ +
Sbjct: 1319 LKRQLEEETKAKSTLAHA----------LQSARHDCDLLREQYE-EEQEAKAELQRGMSK 1367
Query: 135 CVSVQCQKQIKELRDQIV---SVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNS 191
S Q + K D I ++E KK LA L++ + + V + +++ K L +
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQN 1427
Query: 192 EVLEQRKVLEKCNRVSMLA--------------VEEYEEMQVNLELEKDLRKKAESFAQE 237
EV + +E+ N + ++YEE Q LE + K++ S + E
Sbjct: 1428 EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQ---KESRSLSTE 1484
Query: 238 MFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENE 297
+F +N A +E+ + L+ E QQ++ +L EQ+
Sbjct: 1485 LFKVKN---------------------AYEESLDHLETLKRENKNLQQEISDLTEQIAEG 1523
Query: 298 TLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
H IH L++ + L+ +K EL+ + +E + + + +Q +NQ ++ +
Sbjct: 1524 GKH--IHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Score = 49.7 bits (117), Expect = 6e-06
Identities = 71/350 (20%), Positives = 146/350 (41%), Gaps = 62/350 (17%)
Query: 4 SDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVI 63
SD ++L+ I+ E+A G N+K + + K+R++ +E+
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEST-------------- 1186
Query: 64 EEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDED 123
+Q+ ++ A+++A +L ++ +L+R+ KL + ++ I+D
Sbjct: 1187 -----LQHEATAAALRKKHADSVA-ELGEQIDSLQRVKQ----KLEKEKSELKMEINDLA 1236
Query: 124 STTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVK 183
S +T A+ C + +++ +I + +EE++ L EL K++L E ++
Sbjct: 1237 SNMETVSKAKANFEKMC-RTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQL 1295
Query: 184 QEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQN 243
EK + S++ +R ++ EE++ LE E+
Sbjct: 1296 DEKDAMVSQL----------SRGKQAFTQQIEELKRQLE------------------EET 1327
Query: 244 KLKRQSHLLLQSSIPDQQLLK-ALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKE 302
K K LQS+ D LL+ +E + +L+ + +V + + E + +
Sbjct: 1328 KAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAI--- 1384
Query: 303 IHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
Q+ E LEE KK+L + Q++EE + L+K + +N V
Sbjct: 1385 -----QRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEV 1429
Score = 47.8 bits (112), Expect = 2e-05
Identities = 42/216 (19%), Positives = 102/216 (47%), Gaps = 19/216 (8%)
Query: 137 SVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQ 196
S + +K++ ++++ +EE + + L+ K+V +++E N ++ + + +E
Sbjct: 846 SAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ---VQAEADAL 902
Query: 197 RKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSS 256
E+C+++ ++ ++LE +++ E E I ++ L + S
Sbjct: 903 ADAEERCDQL----------IKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 952
Query: 257 IPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEED 316
+L K +D+ ++E+E+ + KVK L E++ L + I L ++ + L+E
Sbjct: 953 ----ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG--LDETIAKLTKEKKALQEA 1006
Query: 317 KKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
++ Q E+K L + +L+++V+ E S+
Sbjct: 1007 HQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSL 1042
Score = 34.3 bits (77), Expect = 0.24
Identities = 34/167 (20%), Positives = 69/167 (41%), Gaps = 16/167 (9%)
Query: 286 KVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345
K+K L + E E KE+ N+K++ E +E+ + E K + EEK L ++LQ +V
Sbjct: 839 KIKPLLKSAETE---KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV 895
Query: 346 NQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKKEKATQPETTEEVTDL 405
+++ L I++ + + K + E+A E
Sbjct: 896 QAEADALADAEERCDQL-------IKTKIQLEAKIKEVT------ERAEDEEEINAELTA 942
Query: 406 KRQAVEEMMDRIKKGVHLRPVNQTARPKTKPESSKGCESAVDELKGI 452
K++ +E+ +KK + + K K + ++ +E+ G+
Sbjct: 943 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 989
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 70.9 bits (172), Expect = 2e-12
Identities = 77/346 (22%), Positives = 166/346 (47%), Gaps = 31/346 (8%)
Query: 8 KQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKK--LEEFQKISHMVIEE 65
K LQ T+ + A+ E+ AE ++T E+ K +++RDE K+ ++ ++K + E+
Sbjct: 602 KSLQADTTNTDTALTTLEEALAEKERTIERL-KEQRDRDEREKQEEIDNYKKDLKDLKEK 660
Query: 66 VNFMQNHLEIEKTC----RESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDD 121
V+ +Q L ++ +E A +LA+ K++ LK + + K EE +
Sbjct: 661 VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQK------KEECLKME 714
Query: 122 EDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNK 181
+ A E S + +I+ L +I ++E E++ +L+E+++EV
Sbjct: 715 SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD----RLLEILKEVEN 770
Query: 182 VKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIE 241
K +K +E+ +R+V ++ +V+ L +E E + + ++ ++ R++ ++
Sbjct: 771 EKNDKDKKIAEL--ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 828
Query: 242 QNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHK 301
Q+ L+++ + ++L +AL E+ ++T + E Q + E+Q+E +
Sbjct: 829 QDSLRKKDDRI-------EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAM 881
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ 347
E +KQ+LE + K +L Q+ EK +L + E +K + +
Sbjct: 882 E--KVKQELESM---KAKLSSTQQSLAEKETHLTNLRAERRKHLEE 922
Score = 67.0 bits (162), Expect = 3e-11
Identities = 85/350 (24%), Positives = 154/350 (44%), Gaps = 51/350 (14%)
Query: 4 SDEEKQLQLITSLKEQAIGEYE----DLRAENQKTKEKCDKIRQERDEAVKKLEEFQKIS 59
S + K LQ + +K+ I E DL E Q K +ER+E +K++E ++ S
Sbjct: 374 SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHS 433
Query: 60 HMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINI 119
FM+N +E K S EA +L K+ L+ A++G V E
Sbjct: 434 -------KFMKNKVEQLKEELSSKEAQWEELKKKAAGLQ-------AEIG-QVKQELSRK 478
Query: 120 DDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEV 179
D E T T ++ I+ L++ + + ++ IL E++ L+ +L E +
Sbjct: 479 DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETML 538
Query: 180 NK-------VKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAE 232
NK + +EK E+ + + +L+ +E +VN+ L+KK E
Sbjct: 539 NKKTKQIQDMAEEKGTQAGEIHDLKDMLD------------VKERKVNV-----LQKKIE 581
Query: 233 SFAQEMFIEQNKLKRQSHLL-----LQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKV 287
+ +++ ++K K+ S L LQ+ + E A ++ ER++ Q+
Sbjct: 582 NLQEQL---RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 638
Query: 288 KELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHS 337
E E+Q E + K++ +LK+++ LL+ D E E + +E A +L S
Sbjct: 639 DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 688
Score = 60.8 bits (146), Expect = 2e-09
Identities = 79/372 (21%), Positives = 154/372 (41%), Gaps = 72/372 (19%)
Query: 4 SDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQK---ISH 60
++ E+Q + + L++ E +LR E QK + RDE++KKL E + +S
Sbjct: 272 AEHERQAKELFLLRKTL--EEMELRIETQK------QTLNARDESIKKLLEMLQSKGLSA 323
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLK---------------------- 98
EE + L + E+L + KEN L+
Sbjct: 324 KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTV 383
Query: 99 ---RISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQ-IKELRDQIVSV 154
+ S + + G + EEI + + T+ E ++ + K +++++ +
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQL 443
Query: 155 QEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEY 214
+EE + E LK K + E+ +VKQE + ++E+L + LE ++
Sbjct: 444 KEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN-------QF 496
Query: 215 EEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQ 274
+ + ++E+ K E K Q +LQ+ + +L
Sbjct: 497 SDSKQHIEVLK---------------ESLTAKEQRAAILQTEVDALRL------------ 529
Query: 275 QLEEERIQHQQKVKELEEQLENE-TLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARN 333
+LEE+ +K K++++ E + T EIH+LK L++ E L+ K +N +E+ R+
Sbjct: 530 RLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRD 589
Query: 334 LKHSVDELQKRV 345
+ + L++RV
Sbjct: 590 KEKQMSSLKERV 601
Score = 58.5 bits (140), Expect = 1e-08
Identities = 72/340 (21%), Positives = 152/340 (44%), Gaps = 51/340 (15%)
Query: 31 NQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKL 90
N+KTK+ D + +E+ ++ + + + + +VN +Q +E E L K
Sbjct: 539 NKKTKQIQD-MAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE------NLQEQLRDKE 591
Query: 91 NKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQ--IKELR 148
+ + +R+ L + TT+TD A T +K+ I+ L+
Sbjct: 592 KQMSSLKERVKSL------------------QADTTNTDTALTTLEEALAEKERTIERLK 633
Query: 149 DQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKV--------L 200
+Q + EK+ E++N K L ++ E+V+ ++ + + + +L+ ++ L
Sbjct: 634 EQRDRDEREKQE---EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGL 690
Query: 201 EKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQ 260
+K +R+ L + ++ + L++E L KKA A E R HL + +
Sbjct: 691 KKDSRLKTLEIALEQKKEECLKMESQL-KKAHEAALEARASPEMSDRIQHLEREITRYKD 749
Query: 261 QLLKA---LDENAKLTQQLEEERIQHQQKVKELEEQLENETL------HKEIHNLKQQLE 311
+ KA +D ++ +++E E+ +K+ ELE Q++++ HKE K+ +
Sbjct: 750 ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQ 809
Query: 312 LLEEDKK---ELELKYQNSEEKARNLKHSVDELQKRVNQS 348
+LEE ++ L Q ++ R ++EL++ + +S
Sbjct: 810 MLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES 849
Score = 38.1 bits (87), Expect = 0.017
Identities = 51/278 (18%), Positives = 114/278 (41%), Gaps = 41/278 (14%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVK------KLEEFQKI 58
DE + Q + + E E+ +N K K+ + RQ +D+ K K + +K
Sbjct: 749 DESSKAQAEVDRLLEILKEVEN--EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKK 806
Query: 59 SHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN 118
S ++EE +++L +S++ L L K++ ++ + + E +
Sbjct: 807 SAQMLEEARRREDNLN------DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVL 860
Query: 119 IDDEDSTTDTDGAAETCVSV--QCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVI 176
+E + T+ + E + + +++++ ++ ++ S Q+ L NL+++ + +
Sbjct: 861 AQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL 920
Query: 177 EEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFA- 235
EEV ++KQE + A+ E + LEL +K E A
Sbjct: 921 EEVLEMKQE--------------------ALLAAISEKDANIALLELSSSKKKTQEEVAA 960
Query: 236 ----QEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDEN 269
++ ++Q K + Q+ + L + + K+ N
Sbjct: 961 LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSN 998
Score = 30.0 bits (66), Expect = 4.5
Identities = 37/173 (21%), Positives = 81/173 (46%), Gaps = 14/173 (8%)
Query: 172 LVEVIEEVNKVKQEKTVLNSEV-LEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKK 230
++++ ++ +V +E +L +V +++ K+ N + E L+ E+ LRK
Sbjct: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPE-------LKKERALRKD 203
Query: 231 AESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQK--VK 288
E+ ++ EQ ++ ++ + +Q +I Q L L L Q +++ + V
Sbjct: 204 -EASKITIWKEQYRVVQEENQHMQMTI--QALQDELRIQRDLNQLFQQDSSSRTGEPCVA 260
Query: 289 ELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDEL 341
EL E+ + LH E ++L LL + +E+EL+ + ++ S+ +L
Sbjct: 261 ELTEE-NFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKL 312
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 70.9 bits (172), Expect = 2e-12
Identities = 77/346 (22%), Positives = 166/346 (47%), Gaps = 31/346 (8%)
Query: 8 KQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKK--LEEFQKISHMVIEE 65
K LQ T+ + A+ E+ AE ++T E+ K +++RDE K+ ++ ++K + E+
Sbjct: 574 KSLQADTTNTDTALTTLEEALAEKERTIERL-KEQRDRDEREKQEEIDNYKKDLKDLKEK 632
Query: 66 VNFMQNHLEIEKTC----RESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDD 121
V+ +Q L ++ +E A +LA+ K++ LK + + K EE +
Sbjct: 633 VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQK------KEECLKME 686
Query: 122 EDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNK 181
+ A E S + +I+ L +I ++E E++ +L+E+++EV
Sbjct: 687 SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD----RLLEILKEVEN 742
Query: 182 VKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIE 241
K +K +E+ +R+V ++ +V+ L +E E + + ++ ++ R++ ++
Sbjct: 743 EKNDKDKKIAEL--ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 800
Query: 242 QNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHK 301
Q+ L+++ + ++L +AL E+ ++T + E Q + E+Q+E +
Sbjct: 801 QDSLRKKDDRI-------EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAM 853
Query: 302 EIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQ 347
E +KQ+LE + K +L Q+ EK +L + E +K + +
Sbjct: 854 E--KVKQELESM---KAKLSSTQQSLAEKETHLTNLRAERRKHLEE 894
Score = 60.5 bits (145), Expect = 3e-09
Identities = 87/426 (20%), Positives = 181/426 (42%), Gaps = 86/426 (20%)
Query: 5 DEEKQLQLI-------TSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQK 57
D E+++Q++ T +E+ + + E R+ ++ K K +++QE +L Q
Sbjct: 400 DLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQT 459
Query: 58 ISHMVIEEVNFMQNHLEIEK---TCRESAEALA---------------TKLNKENKTLKR 99
+ + + + H+E+ K T +E A+ T LNK+ K ++
Sbjct: 460 KLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQD 519
Query: 100 ISMLYMAKLGP--------DVITEEINI-------------DDEDS-------------- 124
++ + G DV ++N+ D E
Sbjct: 520 MAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQAD 579
Query: 125 TTDTDGAAETCVSVQCQKQ--IKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKV 182
TT+TD A T +K+ I+ L++Q + EK+ E++N K L ++ E+V+ +
Sbjct: 580 TTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE---EIDNYKKDLKDLKEKVSLL 636
Query: 183 KQEKTVLNSEVLEQRKV--------LEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESF 234
+ + + + +L+ ++ L+K +R+ L + ++ + L++E L KKA
Sbjct: 637 QGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQL-KKAHEA 695
Query: 235 AQEMFIEQNKLKRQSHLLLQSSIPDQQLLKA---LDENAKLTQQLEEERIQHQQKVKELE 291
A E R HL + + + KA +D ++ +++E E+ +K+ ELE
Sbjct: 696 ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE 755
Query: 292 EQLENETL------HKEIHNLKQQLELLEEDKK---ELELKYQNSEEKARNLKHSVDELQ 342
Q++++ HKE K+ ++LEE ++ L Q ++ R ++EL+
Sbjct: 756 RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 815
Query: 343 KRVNQS 348
+ + +S
Sbjct: 816 EALRES 821
Score = 58.2 bits (139), Expect = 2e-08
Identities = 76/343 (22%), Positives = 144/343 (41%), Gaps = 65/343 (18%)
Query: 4 SDEEKQLQLITSLKEQAIGEYE----DLRAENQKTKEKCDKIRQERDEAVKKLEEFQKIS 59
S + K LQ + +K+ I E DL E Q K +ER+E +K++E ++ S
Sbjct: 374 SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHS 433
Query: 60 HMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINI 119
+ ++ ++ L R+ E LA + E T + +K +V+ E +
Sbjct: 434 KFMKNKIGQVKQELS-----RKDTELLALQTKLETLT----NQFSDSKQHIEVLKESLTA 484
Query: 120 DDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEV 179
KE R I+ Q E L + LE ++ L + +++
Sbjct: 485 -------------------------KEQRAAIL--QTEVDALRLRLEEKETMLNKKTKQI 517
Query: 180 NKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMF 239
+ +EK E+ + + +L+ +E +VN+ L+KK E+ +++
Sbjct: 518 QDMAEEKGTQAGEIHDLKDMLD------------VKERKVNV-----LQKKIENLQEQL- 559
Query: 240 IEQNKLKRQSHLL-----LQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQL 294
++K K+ S L LQ+ + E A ++ ER++ Q+ E E+Q
Sbjct: 560 --RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 617
Query: 295 ENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHS 337
E + K++ +LK+++ LL+ D E E + +E A +L S
Sbjct: 618 EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS 660
Score = 55.1 bits (131), Expect = 1e-07
Identities = 77/351 (21%), Positives = 150/351 (42%), Gaps = 58/351 (16%)
Query: 4 SDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQK---ISH 60
++ E+Q + + L++ E +LR E QK + RDE++KKL E + +S
Sbjct: 272 AEHERQAKELFLLRKTL--EEMELRIETQK------QTLNARDESIKKLLEMLQSKGLSA 323
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPD-----VITE 115
EE + L + E+L + KEN L+ M + PD +
Sbjct: 324 KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLRE-EMHRRFENAPDSAKTKALQT 382
Query: 116 EINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEV 175
I + D ++ G + +Q K L + + E+++ +E+ SK ++
Sbjct: 383 VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE----EREEEMKQMEVYRSHSKFMK- 437
Query: 176 IEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFA 235
++ +VKQE + ++E+L + LE ++ + + ++E+ K
Sbjct: 438 -NKIGQVKQELSRKDTELLALQTKLETLTN-------QFSDSKQHIEVLK---------- 479
Query: 236 QEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLE 295
E K Q +LQ+ + +L +LEE+ +K K++++ E
Sbjct: 480 -----ESLTAKEQRAAILQTEVDALRL------------RLEEKETMLNKKTKQIQDMAE 522
Query: 296 NE-TLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345
+ T EIH+LK L++ E L+ K +N +E+ R+ + + L++RV
Sbjct: 523 EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERV 573
Score = 38.1 bits (87), Expect = 0.017
Identities = 51/278 (18%), Positives = 114/278 (41%), Gaps = 41/278 (14%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVK------KLEEFQKI 58
DE + Q + + E E+ +N K K+ + RQ +D+ K K + +K
Sbjct: 721 DESSKAQAEVDRLLEILKEVEN--EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKK 778
Query: 59 SHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEIN 118
S ++EE +++L +S++ L L K++ ++ + + E +
Sbjct: 779 SAQMLEEARRREDNLN------DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVL 832
Query: 119 IDDEDSTTDTDGAAETCVSV--QCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVI 176
+E + T+ + E + + +++++ ++ ++ S Q+ L NL+++ + +
Sbjct: 833 AQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL 892
Query: 177 EEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFA- 235
EEV ++KQE + A+ E + LEL +K E A
Sbjct: 893 EEVLEMKQE--------------------ALLAAISEKDANIALLELSSSKKKTQEEVAA 932
Query: 236 ----QEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDEN 269
++ ++Q K + Q+ + L + + K+ N
Sbjct: 933 LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSN 970
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 70.1 bits (170), Expect = 4e-12
Identities = 80/366 (21%), Positives = 175/366 (47%), Gaps = 32/366 (8%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQ----KTKEKCDKIRQERDEAVKKLEEFQKISH 60
++E+ QL + +E+ E ++ + Q K EK ++ ++R+E +K E ++ +
Sbjct: 379 EQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAK 438
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
+E Q LE E+ R+ LN+ NK + I +L K + E +N
Sbjct: 439 RELER----QRQLEWERNRRQEL------LNQRNKEQEDIVVLKAKKKTLEFELEALN-- 486
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
D +G + ++C+ + R +I S + +++ E+ +L+ +L E + +
Sbjct: 487 --DKKHQLEGKLQ---DIRCR--LTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLG 539
Query: 181 KVKQEKTVLNSEVLE-QRKVLEKCNRVSML-AVEEYEEMQVNLELEKD-LRKKAESFAQE 237
++ EK +LN ++ + Q+ L + + V++ A+E E + +L + D + K+ S QE
Sbjct: 540 RLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQE 599
Query: 238 MFIEQNKLKRQSHLLLQSSIPDQQLLKA----LDENAKLTQQLEEERIQHQQKVKELEEQ 293
+ I N+LK + + + Q+ ++A E + +LE+++ + Q++ +E ++Q
Sbjct: 600 IDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQ 659
Query: 294 LENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVP 353
++ H ++L E+ K+E +K ++ EEK + + + D+L + +Q +
Sbjct: 660 WLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGK--QEAQDKLGRLFHQHQEPAK 717
Query: 354 PPPPPP 359
P P
Sbjct: 718 PAVQAP 723
Score = 46.6 bits (109), Expect = 5e-05
Identities = 61/299 (20%), Positives = 125/299 (41%), Gaps = 26/299 (8%)
Query: 157 EKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSE------VLEQRKVLEKCNRVSMLA 210
E+ +L E + L+ KL E+ + E+ L E + +QRK E+ ++
Sbjct: 331 EEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAE 390
Query: 211 VEEYE------EMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLK 264
E E E + LELEK L K+ E Q + +++R+ +++ + + +
Sbjct: 391 QERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERR-----EAAKRELERQR 445
Query: 265 ALDENAKLTQQLEEERIQHQQ-----KVKELEEQLENETLHKEIHNLKQQLE----LLEE 315
L+ Q+L +R + Q+ K K+ + E E L+ + H L+ +L+ L
Sbjct: 446 QLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTT 505
Query: 316 DKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMS 375
++E+E ++ E + + H +LQ+ +P L N +
Sbjct: 506 QRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSL 565
Query: 376 MIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKT 434
+ KR+ + A++ Q + E+ T K Q ++ +++K+ + Q + K+
Sbjct: 566 VTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKS 624
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 70.1 bits (170), Expect = 4e-12
Identities = 80/366 (21%), Positives = 175/366 (47%), Gaps = 32/366 (8%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQ----KTKEKCDKIRQERDEAVKKLEEFQKISH 60
++E+ QL + +E+ E ++ + Q K EK ++ ++R+E +K E ++ +
Sbjct: 379 EQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAK 438
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
+E Q LE E+ R+ LN+ NK + I +L K + E +N
Sbjct: 439 RELER----QRQLEWERNRRQEL------LNQRNKEQEDIVVLKAKKKTLEFELEALN-- 486
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
D +G + ++C+ + R +I S + +++ E+ +L+ +L E + +
Sbjct: 487 --DKKHQLEGKLQ---DIRCR--LTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLG 539
Query: 181 KVKQEKTVLNSEVLE-QRKVLEKCNRVSML-AVEEYEEMQVNLELEKD-LRKKAESFAQE 237
++ EK +LN ++ + Q+ L + + V++ A+E E + +L + D + K+ S QE
Sbjct: 540 RLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQE 599
Query: 238 MFIEQNKLKRQSHLLLQSSIPDQQLLKA----LDENAKLTQQLEEERIQHQQKVKELEEQ 293
+ I N+LK + + + Q+ ++A E + +LE+++ + Q++ +E ++Q
Sbjct: 600 IDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQ 659
Query: 294 LENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVP 353
++ H ++L E+ K+E +K ++ EEK + + + D+L + +Q +
Sbjct: 660 WLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGK--QEAQDKLGRLFHQHQEPAK 717
Query: 354 PPPPPP 359
P P
Sbjct: 718 PAVQAP 723
Score = 46.6 bits (109), Expect = 5e-05
Identities = 61/299 (20%), Positives = 125/299 (41%), Gaps = 26/299 (8%)
Query: 157 EKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSE------VLEQRKVLEKCNRVSMLA 210
E+ +L E + L+ KL E+ + E+ L E + +QRK E+ ++
Sbjct: 331 EEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAE 390
Query: 211 VEEYE------EMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLK 264
E E E + LELEK L K+ E Q + +++R+ +++ + + +
Sbjct: 391 QERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERR-----EAAKRELERQR 445
Query: 265 ALDENAKLTQQLEEERIQHQQ-----KVKELEEQLENETLHKEIHNLKQQLE----LLEE 315
L+ Q+L +R + Q+ K K+ + E E L+ + H L+ +L+ L
Sbjct: 446 QLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTT 505
Query: 316 DKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMS 375
++E+E ++ E + + H +LQ+ +P L N +
Sbjct: 506 QRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSL 565
Query: 376 MIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIKKGVHLRPVNQTARPKT 434
+ KR+ + A++ Q + E+ T K Q ++ +++K+ + Q + K+
Sbjct: 566 VTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKS 624
>gi|75677376 coiled-coil domain containing 62 isoform b [Homo
sapiens]
Length = 684
Score = 69.7 bits (169), Expect = 5e-12
Identities = 78/362 (21%), Positives = 158/362 (43%), Gaps = 37/362 (10%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQE---RDEAVKKLEEFQKI--S 59
D +K+L + ++ +Q + +E+ R + +E+C K+ E R E ++ L + K S
Sbjct: 39 DRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALES 98
Query: 60 HMVIEEVNFMQNHLEIEKTCRESAEA--LATKLNKENKTLKRISMLYMAKLGP-----DV 112
+ + + + L++++ +++ + L+ L N+TL + A++G
Sbjct: 99 NQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQA 158
Query: 113 ITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKL 172
+T I + D+D + A+ C + K L + + + + E ++ K KL
Sbjct: 159 LTTMIKLKDKDIIEAVNHIAD------CSGKFKMLEHALRDAKMAETCIVKEKQDYKQKL 212
Query: 173 VEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAE 232
+ EVNK+K++ LN + E + E+ R+ ++E+ +E E K+ +
Sbjct: 213 KALKIEVNKLKED---LNEKTTENNEQREEIIRLKQEKSCLHDELLFTVERE----KRKD 265
Query: 233 SFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELE- 291
+Q + + H L Q + Q L+ L+ N + +Q+L + ++ K L+
Sbjct: 266 ELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDS 325
Query: 292 ------EQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345
LEN +I K Q L ++ K E L QN +K+ S DE +++
Sbjct: 326 SRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKS-----SCDECKEKK 380
Query: 346 NQ 347
Q
Sbjct: 381 QQ 382
>gi|30348972 coiled-coil domain containing 62 isoform a [Homo
sapiens]
Length = 682
Score = 69.7 bits (169), Expect = 5e-12
Identities = 78/362 (21%), Positives = 158/362 (43%), Gaps = 37/362 (10%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQE---RDEAVKKLEEFQKI--S 59
D +K+L + ++ +Q + +E+ R + +E+C K+ E R E ++ L + K S
Sbjct: 39 DRDKELNDMVAVHQQQLLSWEEDRQKVLTLEERCSKLEGELHKRTEIIRSLTKKVKALES 98
Query: 60 HMVIEEVNFMQNHLEIEKTCRESAEA--LATKLNKENKTLKRISMLYMAKLGP-----DV 112
+ + + + L++++ +++ + L+ L N+TL + A++G
Sbjct: 99 NQMECQTALQKTQLQLQEMAQKATHSSLLSEDLEARNETLSNTLVELSAQVGQLQAREQA 158
Query: 113 ITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKL 172
+T I + D+D + A+ C + K L + + + + E ++ K KL
Sbjct: 159 LTTMIKLKDKDIIEAVNHIAD------CSGKFKMLEHALRDAKMAETCIVKEKQDYKQKL 212
Query: 173 VEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAE 232
+ EVNK+K++ LN + E + E+ R+ ++E+ +E E K+ +
Sbjct: 213 KALKIEVNKLKED---LNEKTTENNEQREEIIRLKQEKSCLHDELLFTVERE----KRKD 265
Query: 233 SFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELE- 291
+Q + + H L Q + Q L+ L+ N + +Q+L + ++ K L+
Sbjct: 266 ELLNIAKSKQERTNSELHNLRQIYVKQQSDLQFLNFNVENSQELIQMYDSKMEESKALDS 325
Query: 292 ------EQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRV 345
LEN +I K Q L ++ K E L QN +K+ S DE +++
Sbjct: 326 SRDMCLSDLENNHPKVDIKREKNQKSLFKDQKFEAMLVQQNRSDKS-----SCDECKEKK 380
Query: 346 NQ 347
Q
Sbjct: 381 QQ 382
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 69.3 bits (168), Expect = 7e-12
Identities = 84/348 (24%), Positives = 147/348 (42%), Gaps = 72/348 (20%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
++E+++ I + +A E + R E Q KE+ + +R E+D+ + + ++
Sbjct: 962 EKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRD------LIQG 1015
Query: 65 EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDS 124
++ LE EK +E L + + N RI L + E IN D+ED
Sbjct: 1016 AESYKNLLLEYEK----QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQ 184
+ Q K L QI+ VQ K ++ ELE E +++ K+K+
Sbjct: 1072 LARIE---------TLQSNAKLLEVQILEVQRAKAMVDKELE------AEKLQKEQKIKE 1116
Query: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNK 244
T +N E EE+QV L+ EK K+ + QE+ E K
Sbjct: 1117 HATTVN----------------------ELEELQVQLQKEK---KQLQKTMQEL--ELVK 1149
Query: 245 LKRQSHLLLQSSIPD-QQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEI 303
Q L+ I D ++L+K L N KLT + K+++LE++++ +
Sbjct: 1150 KDAQQTTLMNMEIADYERLMKEL--NQKLTNK--------NNKIEDLEQEIKIQ------ 1193
Query: 304 HNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENS 351
KQ+ E L+E+ L+ Q EEK +K + + +K + S+ +
Sbjct: 1194 ---KQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA 1238
Score = 66.6 bits (161), Expect = 4e-11
Identities = 99/499 (19%), Positives = 199/499 (39%), Gaps = 90/499 (18%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
E ++ +T K+ I + ++ E +KC++ + E KK+E+ + + + ++V
Sbjct: 586 EGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKV 645
Query: 67 NFM------------QNHLEIEK------TCRESAEALAT----------KLNKENKTLK 98
N + QN ++EK E E L+ KL+ E K L
Sbjct: 646 NELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLS 705
Query: 99 RISMLYMAKLGPDVITEEIN---------IDDEDSTT---DTDGAAETCVSVQCQKQIKE 146
R +++++ ++ E I ++++D+ + + + V Q +KE
Sbjct: 706 RDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKE 765
Query: 147 LRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVL----NSEVLEQRKVLEK 202
+ ++ EEK ++ + L V E + K+ +EK L + +VLE K ++
Sbjct: 766 MGSEVSEDSEEKDVVNV--------LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKC 817
Query: 203 CNRVSMLAVEEYEEMQVNLELEKDL-RKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ 261
S++ EE + + + E EK L RK+ E E Q+ L + ++ + +Q
Sbjct: 818 LQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQN 877
Query: 262 LLKALDE------NAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEE 315
LL ++E +++ + E+ I+ + +K L EQ E E+ LK L
Sbjct: 878 LLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPS 937
Query: 316 DKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMS 375
K + + EEK NL+ E ++++N+ +
Sbjct: 938 VKNDPLSSVKELEEKIENLEKECKEKEEKINK--------------------------IK 971
Query: 376 MIRKRSHPSGSGAKKEKATQPETTEEVTDLKRQAVEEMMDRIK-----KGVHLRPVNQTA 430
++ ++ ++KE T E E + K Q M D I+ K + L Q+
Sbjct: 972 LVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSE 1031
Query: 431 RPKTKPESSKGCESAVDEL 449
+ + E + E +++L
Sbjct: 1032 QLDVEKERANNFEHRIEDL 1050
Score = 65.1 bits (157), Expect = 1e-10
Identities = 75/342 (21%), Positives = 150/342 (43%), Gaps = 41/342 (11%)
Query: 6 EEKQLQLITSLKEQAIGEYED----LRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHM 61
+E+ + I+ L E + + E L E Q KE+C+ ++QE+ EA+ E ++I +
Sbjct: 430 KEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEI 489
Query: 62 VIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDD 121
+ E+ E + S E + K + + + L A D + E +N
Sbjct: 490 LQTELG--------ESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVN--- 538
Query: 122 EDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNK 181
G E +S Q+ + EL + I ++QE+ + + L + L E+ ++N
Sbjct: 539 -----RLQGENEKLLSQ--QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINS 591
Query: 182 VKQEK----TVLNSEVLEQRKVLEKCNRVSMLAVE----EYEEMQVNLELEKDLRKKAES 233
+ +EK L + E +KC R L +E + +Q N ELE+ + +
Sbjct: 592 LTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGG 651
Query: 234 FAQEMFIEQNKLKRQSHLLLQSSI--PDQQLLKA-----LDENAKLTQQLEEERIQHQQK 286
+ + + ++ L++Q + D+++L A +EN KL+ E+ Q +
Sbjct: 652 LEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLS----SEKKQLSRD 707
Query: 287 VKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSE 328
++ Q E+ L + I L+++L+L+ E++ L +N +
Sbjct: 708 LEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ 749
Score = 57.8 bits (138), Expect = 2e-08
Identities = 88/385 (22%), Positives = 163/385 (42%), Gaps = 57/385 (14%)
Query: 21 IGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCR 80
+ E E+L+ E + K +++ K+LEE + E++ F N + K +
Sbjct: 128 VKEIENLKNELMAVRSKYS---EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQ 184
Query: 81 ESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDST---TDTDGAAETCVS 137
E E + ++ L++ + + +T+ NI + +S + + E +
Sbjct: 185 EEIEKIRPGFEEQILYLQK-QLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQ 243
Query: 138 VQC--QKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLE 195
++ Q+++KEL QI + +E + +L LK LV+ E K Q+K E L
Sbjct: 244 LKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLR 303
Query: 196 QRK------------VLEKCNRVSMLAVEEYEEMQVNL-ELEK-------------DLRK 229
+ +L++ V + E+ + ++ L ELE +L+
Sbjct: 304 KATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKL 363
Query: 230 KAESFAQ----EMFIEQNKLK-RQSHLLLQSSIPDQQLLKALDENAKLTQQ--------- 275
K E AQ E F E+ L+ + + LLL + K E A L +Q
Sbjct: 364 KLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHN 423
Query: 276 --LEEERIQHQQKVKELEE------QLENETLHKEIHNLKQQLELLEEDKKELELKYQNS 327
++ + QHQ+++ EL E + E TL EI LK+Q E L+++K+E L Y++
Sbjct: 424 REVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESL 483
Query: 328 EEKARNLKHSVDELQKRVNQSENSV 352
E L+ + E +++Q S+
Sbjct: 484 REIMEILQTELGESAGKISQEFESM 508
Score = 51.2 bits (121), Expect = 2e-06
Identities = 45/154 (29%), Positives = 73/154 (47%), Gaps = 4/154 (2%)
Query: 200 LEKCNRVSMLAVEEYEEMQVNLELE-KDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIP 258
L K + M+ +++ + LE E ++LR K + I+ +R LLL+ +
Sbjct: 30 LIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKA-LTERLDALLLEKAET 88
Query: 259 DQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKK 318
+QQ L EN K+ Q++E+ + KELE+ N KEI NLK +L +
Sbjct: 89 EQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYV--KEIENLKNELMAVRSKYS 146
Query: 319 ELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
E + Q E+A N + + E K N SE++V
Sbjct: 147 EDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNV 180
Score = 47.4 bits (111), Expect = 3e-05
Identities = 67/358 (18%), Positives = 151/358 (42%), Gaps = 30/358 (8%)
Query: 1 MNSSDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH 60
M +D E+ ++ + + EDL E + K+K + +++E ++++++ +
Sbjct: 1160 MEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNT 1219
Query: 61 MVIEEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
+ + + + L K L L E + ++ +Y +L IT E +
Sbjct: 1220 KIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE--ITSEKHKI 1277
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIE--- 177
E T + T + Q+++ L+++ + + E+ + E E+ K ++ V++
Sbjct: 1278 HEHLKTSAEQHQRTLSAY--QQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK 1335
Query: 178 -------EVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLE--LEKDLR 228
E KQE+ L + + + L+ + V E + +Q + LE+ +
Sbjct: 1336 NKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNK 1395
Query: 229 KKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVK 288
E+ ++E + + QS ++ S Q + ++LT Q E R + +V+
Sbjct: 1396 MLQETVSKEAELREKLCSIQSENMMMKSEHTQTV-------SQLTSQNEVLRNSFRDQVR 1448
Query: 289 ELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVN 346
L+E+ K + L+QQL +E + +LK + + + + S+ L++R N
Sbjct: 1449 HLQEE-----HRKTVETLQQQLSKME--AQLFQLKNEPTTRSPVSSQQSLKNLRERRN 1499
Score = 44.3 bits (103), Expect = 2e-04
Identities = 80/386 (20%), Positives = 165/386 (42%), Gaps = 55/386 (14%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKIS--HMV 62
D E+++++ +E E L++ Q+ +EK KI+Q + K+L + ++ H++
Sbjct: 1185 DLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLI 1244
Query: 63 IE-----EVNFMQNHLEIEKTC--------RESAEALATKLNKENKTL----KRISMLY- 104
++ E+ Q +E+ K + E L T + +TL +R++ L
Sbjct: 1245 LQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
Query: 105 ---MAKLGPDVITEE-----INIDD--EDSTTDTDGAAETCVSVQCQKQIKELRDQI-VS 153
AK +T E + + + + + AET + Q ++ ++ L DQ+ +
Sbjct: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIK 1364
Query: 154 VQEEKKILAI---ELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLA 210
+Q+ + L I EL+ L+S+ ++E NK+ QE S+ E R+ L +M+
Sbjct: 1365 LQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETV---SKEAELREKLCSIQSENMMM 1421
Query: 211 VEEYEEMQVNLELEKDLRKKAESFAQEM-FIEQNKLKRQSHLLLQSSIPDQQLLKALDEN 269
E+ + L + ++ + SF ++ +++ K L Q S + QL + +E
Sbjct: 1422 KSEHTQTVSQLTSQNEVLR--NSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNE- 1478
Query: 270 AKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEE 329
+ QQ +K L E+ + ++H + + E+ + +E S
Sbjct: 1479 -----PTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTR------EEGEGMETTDTESVS 1527
Query: 330 KARNLKHSVDELQKRVNQSENSVPPP 355
A S+++L +N E + PP
Sbjct: 1528 SASTYTQSLEQL---LNSPETKLEPP 1550
Score = 42.7 bits (99), Expect = 7e-04
Identities = 68/325 (20%), Positives = 131/325 (40%), Gaps = 71/325 (21%)
Query: 32 QKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLN 91
QK K +C ++ +E +E K ++ + + + L+ + E L
Sbjct: 42 QKAKSRCTELEKEIEELRSK-----PVTEGTGDIIKALTERLDALLLEKAETEQQCLSLK 96
Query: 92 KENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQI 151
KEN +K+ + EDS T A KEL
Sbjct: 97 KENIKMKQ--------------------EVEDSVTKMGDAH------------KELEQSH 124
Query: 152 VSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAV 211
++ +E + L EL ++SK E ++ N KQ + +N++ L +
Sbjct: 125 INYVKEIENLKNELMAVRSKYSE--DKANLQKQLEEAMNTQ----------------LEL 166
Query: 212 EEYEEMQVNLE-----LEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKAL 266
E + Q N E L++++ K F +++ Q +L + ++ Q +++A
Sbjct: 167 SEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEAN 226
Query: 267 DEN-AKLTQQLEEERIQ----HQQKVKELEEQL-----ENETLHKEIHNLKQQL-ELLEE 315
++ K L+EE +Q HQ++VKEL Q+ E+E +++ LK+ L + E
Sbjct: 227 SQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEA 286
Query: 316 DKKELELKYQNSEEKARNLKHSVDE 340
+K ++ KY+ E R + ++
Sbjct: 287 SEKNIQKKYECELENLRKATSNANQ 311
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 69.3 bits (168), Expect = 7e-12
Identities = 84/367 (22%), Positives = 173/367 (47%), Gaps = 49/367 (13%)
Query: 4 SDEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKI-RQERDEAVKKLEEFQKISHMV 62
++ E +L + A+ ++ D + +T+ +++ R+ ++ AV ++ Q++ +
Sbjct: 1443 AEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQ 1502
Query: 63 IEEVNFMQNHLEIEKTCRESAEALATK------LNKENKTLKRISMLYMAKLGPDVITEE 116
+ + Q+ ++ E+ +E + +A K L+K+ + L + KL D+ E
Sbjct: 1503 ADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTE----ELQKLQKDIEMAE 1558
Query: 117 INIDDEDSTTDTDGAAETCVSVQCQK-QIKELRDQIVSVQEEKKILAIELENLKSKLVEV 175
N D E+ V +Q ++ ++++L+ Q+ S Q+E +L +L + K +L
Sbjct: 1559 RNEDHHLQVLK-----ESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELH-- 1611
Query: 176 IEEVNKVKQEKTVLNSEVLEQRKVLEKCNRV----SMLAVEEYEEMQVNLELEKDLRKKA 231
+ + + V+ + + + L + +V EKCN + S+L +++ ++N+++ +
Sbjct: 1612 LLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELSFQKGELNVQI-------S 1664
Query: 232 ESFAQEMFIEQNKLKRQSHL---LLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVK 288
E Q I+Q K + +L L Q S +L LD +L+ ++QH Q+V
Sbjct: 1665 ERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVS 1724
Query: 289 E--------LEEQLENETLHKEIHNLKQQLE----LLEEDKKELELKYQNSEEKARNLKH 336
E LEE+LE E L + K ++E LLE DK+E+E ++R L+
Sbjct: 1725 ELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIE----RMTAESRALQS 1780
Query: 337 SVDELQK 343
V+ L K
Sbjct: 1781 CVECLSK 1787
Score = 65.1 bits (157), Expect = 1e-10
Identities = 86/378 (22%), Positives = 166/378 (43%), Gaps = 50/378 (13%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
++++ + + + K Q+ E E+L ++ + E +E + +++ Q+ +
Sbjct: 1338 KKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGN 1397
Query: 66 VNFMQNHLEIEKTCR------ESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINI 119
V + LEIEK+ + + E + L K L+ L T+E
Sbjct: 1398 VESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTK 1457
Query: 120 DDEDSTTD-------TDGAAETCVSVQCQKQIKELRDQIVSVQEEKKIL---AIELENLK 169
+ + TD T+ AE + +++ +E +V ++ + L A +LE K
Sbjct: 1458 NAVEKFTDAKRSLLQTESDAE-----ELERRAQETAVNLVKADQQLRSLQADAKDLEQHK 1512
Query: 170 SKLVEVIEEVNKV-----------KQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQ 218
K E+++E+NK+ ++K L E+ + +K +E R ++ +E +
Sbjct: 1513 IKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESE 1572
Query: 219 VNL-----ELEKDLRKKAESFAQEMFIEQNKL---KRQSHLLLQSSIPDQQLLKALDENA 270
V L ELEK L+ + S QEM + +L K + HLL S + Q L E
Sbjct: 1573 VLLQAKRAELEK-LKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMV---QAKADLQEAL 1628
Query: 271 KLTQQLEEERIQHQQKVKELEEQL--ENETLHKEIHNLKQQLEL----LEEDKKELELKY 324
+L + E+ H ++VK L E+L + L+ +I K QL L +E++++ L++
Sbjct: 1629 RLGETEVTEKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVL 1688
Query: 325 QNSEEKARNLKHSVDELQ 342
+ + LK+ +D LQ
Sbjct: 1689 RQMSKHKTELKNILDMLQ 1706
Score = 59.7 bits (143), Expect = 5e-09
Identities = 87/461 (18%), Positives = 186/461 (40%), Gaps = 55/461 (11%)
Query: 5 DEEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIE 64
+E+ +L+ + + +Q GE E + ++ K + +++ E +E K + E
Sbjct: 1735 EEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQE 1794
Query: 65 EVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDS 124
+ + + L K +AE + E L+++ L + KL ++ +++N D
Sbjct: 1795 KCDIWEKKLAQTKRVLAAAEENS---KMEQSNLEKLE-LNVRKLQQEL--DQLNRDKLSL 1848
Query: 125 TTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQ 184
D Q+Q++E R+ + S+QEE + L K L+ + + +
Sbjct: 1849 HNDISAM---------QQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLS 1899
Query: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEK-----------DLRKKAES 233
E+T L ++ E E C + ++ + +Q +E K L+K+ ES
Sbjct: 1900 EQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERES 1959
Query: 234 FAQEMFIEQNKLKRQSHLL--------------LQSSIPDQQLLKALDENAKLTQQLEEE 279
++ + LK Q H L L + ++ ++ L E + + LE+
Sbjct: 1960 EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKT 2019
Query: 280 RIQHQQKVKELEEQLENET-----LHKEIHNLKQQLELLEE----DKKELELKYQNSEEK 330
Q ++++ E E+QL ++ L KE +++ LL ++K+ E + + +E
Sbjct: 2020 LSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEA 2079
Query: 331 ARNLKHSVDELQKRVNQSENSVPPPPPPPPPLPPPPPNPIRSLMSMIRKRSHPSGSGAKK 390
+ + +++ Q + + + R LM + + + + KK
Sbjct: 2080 LKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQY-EYTELKK 2138
Query: 391 EKATQPETTE---EVTDLKRQAVEEMMDRIKKGVHLRPVNQ 428
+ A Q + E++D R E+ D I+ L+ +NQ
Sbjct: 2139 QMANQKDLERRQMEISDAMRTLKSEVKDEIR--TSLKNLNQ 2177
Score = 52.4 bits (124), Expect = 9e-07
Identities = 62/356 (17%), Positives = 158/356 (44%), Gaps = 38/356 (10%)
Query: 7 EKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEV 66
++ L I QA E LR E + ++ ++ QERD+ + + + + E
Sbjct: 622 QEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELE 681
Query: 67 NFMQNHLEIEKTCRESA-----------------EALATKLNKENKTLKRISMLYMAKLG 109
+ +Q E+ + +++ +A A +L +E + + R++ L + L
Sbjct: 682 SALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQ 741
Query: 110 PDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLK 169
++ E + + G A+ S + +++ EL ++ +Q++ +L +L++ +
Sbjct: 742 AELEKER------QALKNALGKAQ--FSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQ 793
Query: 170 SKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELE-KDLR 228
+ L V++ + V+ E+ + L ++ L + + +L+ + ++
Sbjct: 794 NHLNHVVDGL--VRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEIL 851
Query: 229 KKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVK 288
+++ E + + KL+ + L + Q+ + E A L ++ ++ QH+ +++
Sbjct: 852 ARSKWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERA-LEARMNFDKRQHEARIQ 910
Query: 289 ELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKR 344
++E EIH L++ L+ +EE + +L+ Q ++E+ + + EL+K+
Sbjct: 911 QMEN---------EIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKK 957
Score = 51.6 bits (122), Expect = 1e-06
Identities = 46/203 (22%), Positives = 90/203 (44%), Gaps = 10/203 (4%)
Query: 143 QIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEK 202
+++++ + S + E++ + + ++ E+ ++ + QEK L EV E + ++K
Sbjct: 1327 RLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEELHRTVQK 1386
Query: 203 CNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHL-----LLQSSI 257
+ E + LE+EK L+ + + IE+ LKR+S L LL +
Sbjct: 1387 RQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAE 1446
Query: 258 PDQQLLKALDENA--KLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEE 315
+ K +NA K T + +Q + +ELE + + ++ + QQL L+
Sbjct: 1447 SELSCTKEKTKNAVEKFT-DAKRSLLQTESDAEELERRAQETAVN--LVKADQQLRSLQA 1503
Query: 316 DKKELELKYQNSEEKARNLKHSV 338
D K+LE EE + + V
Sbjct: 1504 DAKDLEQHKIKQEEILKEINKIV 1526
Score = 48.9 bits (115), Expect = 9e-06
Identities = 50/218 (22%), Positives = 99/218 (45%), Gaps = 13/218 (5%)
Query: 139 QCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVL--NSEVLEQ 196
Q +K+++EL I + +EKK L E+E E+ V K +Q+K + N E L
Sbjct: 1351 QSEKEMEELHHNIDDLLQEKKSLECEVE-------ELHRTVQKRQQQKDFIDGNVESLMT 1403
Query: 197 RKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSS 256
+EK + V+E E ++ L + ++A+ E E + K ++ ++
Sbjct: 1404 ELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKF 1463
Query: 257 IPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEED 316
++ L + +A+ ++ +E + K + L+ + E H +KQ+ E+L+E
Sbjct: 1464 TDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQE-EILKEI 1522
Query: 317 KKELELK---YQNSEEKARNLKHSVDELQKRVNQSENS 351
K + K +Q +K L + +LQK + +E +
Sbjct: 1523 NKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERN 1560
Score = 42.4 bits (98), Expect = 9e-04
Identities = 78/386 (20%), Positives = 161/386 (41%), Gaps = 56/386 (14%)
Query: 14 TSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMV-IEEVNFMQNH 72
T L Q + + + A + E D+I + + ++ EEF+++ + +++++
Sbjct: 433 TPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKD 492
Query: 73 LEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDT-DGA 131
L ++ L KL +E L+ L M K ++ ++ I D D+ D
Sbjct: 493 LLYKQL--SGRLQLVNKLRQEALDLE----LQMEKQKQEIAGKQKEIKDLQIAIDSLDSK 546
Query: 132 AETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNS 191
++ QK KE + I++ Q ++ L L+ + S++ + EE+ ++++ L
Sbjct: 547 DPKHSHMKAQKSGKEQQLDIMNKQYQQ--LESRLDEILSRIAKETEEIKDLEEQ---LTE 601
Query: 192 EVLEQRKVLEKCNRVSMLAVEEY------EEMQVNLELEKDLRKKAESFAQ---EMFIEQ 242
+ + L+K + ++EY + Q E K LR + E+ Q E+ E+
Sbjct: 602 GQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRK-LRDEKETLLQRLTEVEQER 660
Query: 243 NKLK---------RQSHLLLQSSIPDQQLLKALDE---------NAKLTQQLEEERIQHQ 284
++L+ R+ L+S++ +Q + A + A+L +L +
Sbjct: 661 DQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN 720
Query: 285 QKVKELEE-----QLENETLHKEIHNLKQQL----------ELLEEDKKELELKYQNSEE 329
Q +ELE+ QLE L E+ +Q L E E++ EL K ++ ++
Sbjct: 721 QLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQD 780
Query: 330 KARNLKHSVDELQKRVNQSENSVPPP 355
LK + + Q +N + + P
Sbjct: 781 DNNLLKQQLKDFQNHLNHVVDGLVRP 806
Score = 41.2 bits (95), Expect = 0.002
Identities = 57/311 (18%), Positives = 132/311 (42%), Gaps = 34/311 (10%)
Query: 53 EEFQKISHMVIEEVNFMQNHLEIEKTCRESAEALATKLNKE-------NKTLKRISMLYM 105
E F++ S +EEV ++ LE + E ++ T+ +E NK+LK +ML
Sbjct: 262 EAFERFS---LEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQ- 317
Query: 106 AKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIEL 165
K + + ++N +E T C QKQ EL ++ + + K +
Sbjct: 318 -KQSCEELKSDLNTKNELLKQKTIELTRAC-----QKQY-ELEQELAFYKIDAKFEPLNY 370
Query: 166 ENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQ---VNLE 222
+ ++ + + + + + +++ V + +E E+++ +NL
Sbjct: 371 YPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLR 430
Query: 223 LEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQ 282
L + E +++ Q +L S L + +QQ+L+A +E +L + ++ ++I
Sbjct: 431 GHTPLDTQLEDKEKKISAAQTRL---SELHDEIEKAEQQILRATEEFKQLEEAIQLKKIS 487
Query: 283 HQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQ 342
K + L+K++ Q + L ++ +LEL+ + +++ + + +LQ
Sbjct: 488 EAGK----------DLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQ 537
Query: 343 KRVNQSENSVP 353
++ ++ P
Sbjct: 538 IAIDSLDSKDP 548
Score = 41.2 bits (95), Expect = 0.002
Identities = 82/369 (22%), Positives = 143/369 (38%), Gaps = 66/369 (17%)
Query: 6 EEKQLQLITSLKEQAIGEYEDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEE 65
E K LQ+ + ++ ++A+ +++ D + ++ + +L+E EE
Sbjct: 532 EIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEE 591
Query: 66 VNFMQNHL-----EIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINID 120
+ ++ L + ++ E + + L + T+K E +
Sbjct: 592 IKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIK--------GQATQAQNECRKLR 643
Query: 121 DEDSTTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVN 180
DE T +Q ++++ RDQ+ V + + + EL L+S L E EVN
Sbjct: 644 DEKETL-----------LQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQ-HEVN 691
Query: 181 KVKQE------------KTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLR 228
Q+ + LN E ++ E+ +V+ L E +Q LE E+
Sbjct: 692 ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQAL 751
Query: 229 KKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLE--EERIQH--- 283
K A AQ F E+ K Q + L + + Q D+N L QQL+ + + H
Sbjct: 752 KNALGKAQ--FSEE---KEQENSELHAKLKHLQ-----DDNNLLKQQLKDFQNHLNHVVD 801
Query: 284 --------QQKVKELEEQLENETLHKEIHNLKQQLELLEEDKKELELKYQNSEEKARNLK 335
+V EL +L+ T IH+ L K +L+ Q SE AR+ K
Sbjct: 802 GLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVL-----GKSLADLQKQFSEILARS-K 855
Query: 336 HSVDELQKR 344
DE Q R
Sbjct: 856 WERDEAQVR 864
Score = 40.8 bits (94), Expect = 0.003
Identities = 39/186 (20%), Positives = 89/186 (47%), Gaps = 16/186 (8%)
Query: 158 KKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKV-LEKCNRVSMLAVEEYEE 216
KK+ ++ + NLK + +++++K+K + +++ ++E V L + ++ + E
Sbjct: 190 KKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLES 249
Query: 217 MQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQ--LLKALDENAKLTQ 274
++ +D ++ E F+ E +E+ + + ++ + +Q L+ + KL +
Sbjct: 250 LEGQPVTTQDRQEAFERFSLEE-VERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNK 308
Query: 275 QLEEERIQHQQKVKELEEQL--ENETLHKEI----------HNLKQQLELLEEDKKELEL 322
L+EE + +Q +EL+ L +NE L ++ + L+Q+L + D K L
Sbjct: 309 SLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPL 368
Query: 323 KYQNSE 328
Y SE
Sbjct: 369 NYYPSE 374
Score = 38.5 bits (88), Expect = 0.013
Identities = 77/382 (20%), Positives = 144/382 (37%), Gaps = 88/382 (23%)
Query: 25 EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISH-----MVIEEVNFMQNHLEIEKTC 79
E++ + +K ++ RQ + A++ F K H + E++++Q +L K+
Sbjct: 870 EEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENL---KSM 926
Query: 80 RESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQ 139
E +L + ++ +RI +A+L + ++ ++D S G
Sbjct: 927 EEIQGLTDLQLQEADEEKERI----LAQLRE--LEKKKKLEDAKSQEQVFGL-------- 972
Query: 140 CQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKV 199
K++K+L+ + + K+ EL K +L + V K+ QE+ E+ +
Sbjct: 973 -DKELKKLKKAVAT---SDKLATAELTIAKDQLKSLHGTVMKINQERA-------EELQE 1021
Query: 200 LEKCNRVSMLAVEEYEEMQVNLELEKD-LRKKAESFAQEMFIEQNKLKRQSHLLLQSSIP 258
E+ +R + A + + +EL ++ LR+K E F EM S +L
Sbjct: 1022 AERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVL------ 1075
Query: 259 DQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLELLEEDKK 318
E KL + +E +R EI L+ L+L D K
Sbjct: 1076 ---------EIEKLNETMERQR--------------------TEIARLQNVLDLTGSDNK 1106
Query: 319 ELELKYQNSEEKARNLKHSVDELQKRVNQSENSVPPPPPPPPP------LPPPPPNPIRS 372
N+ + EL++ V+ + + P +PPPP + + S
Sbjct: 1107 ----------GGFENVLEEIAELRREVSYQNDYISSMADPFKRRGYWYFMPPPPSSKVSS 1156
Query: 373 LMSMIRKRSHPSGSGAKKEKAT 394
S K SG G K +T
Sbjct: 1157 HSSQATK---DSGVGLKYSAST 1175
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 68.9 bits (167), Expect = 9e-12
Identities = 58/340 (17%), Positives = 161/340 (47%), Gaps = 45/340 (13%)
Query: 25 EDLRAENQKTKEKCDKIRQERDEAVKKLEEFQKISHMVIEEVNFMQNHLEIEKTCRESAE 84
E+L+ +N K +EK + E+ E ++E ++ +E + ++ +
Sbjct: 205 EELKEKNAKLQEKLQLVESEKSEIQLNVKELKR----KLERAKLL--------LPQQQLQ 252
Query: 85 ALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQI 144
A A L KE L+ +S A++ + + +N E+ + +Q
Sbjct: 253 AEADHLGKE---LQSVSAKLQAQVEENELWNRLNQQQEE---------------KMWRQE 294
Query: 145 KELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVLEKCN 204
++++++ +QE+++ + + E ++ + + E+ K+++++ ++ + + R++ EK +
Sbjct: 295 EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 354
Query: 205 RVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLK 264
+ +E + + E++ R++ E+ +M+ ++ K++ Q + + Q+ +
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEA---KMWRQEEKIREQEEKIREQEEMMQEQEE 411
Query: 265 ALDENAKLTQQLEEERIQHQQKVKELEEQL--ENETLHKEIHNLKQQLELLEEDKK---- 318
+ E + + EEE + ++K++ EE++ + + + ++ +++Q E+++E ++
Sbjct: 412 KMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGE 471
Query: 319 ------ELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
E E K Q EEK R + + E +K++ + E +
Sbjct: 472 QEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI 511
Score = 62.0 bits (149), Expect = 1e-09
Identities = 80/355 (22%), Positives = 158/355 (44%), Gaps = 57/355 (16%)
Query: 8 KQLQLITSLKEQAIGEYEDLRAENQKTKEKC----DKIRQERDEAVKKLEEFQKISHMVI 63
K+LQ +++ + + E E NQ+ +EK +KI QER+E +++ EE KI
Sbjct: 260 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI-QEREEKIQEQEE--KIR---- 312
Query: 64 EEVNFMQNHLEIEKTCRESAEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDED 123
E E+ R E + K K + EE+ + E+
Sbjct: 313 ----------EQEEKMRRQEEMMWEKEEKMRR------------------QEEMMWEKEE 344
Query: 124 STTDTDGAAETCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVK 183
+ + + + +++R+Q QEE+KI E + + EE + +
Sbjct: 345 KIRELE---------EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 395
Query: 184 QEKTVLNSEVLEQRKVLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQN 243
+EK E++++++ EK E+ EEMQ E + +K +++ ++
Sbjct: 396 EEKIREQEEMMQEQE--EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEE 453
Query: 244 KLKRQSHLLL-QSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQL--ENETLH 300
K++ Q ++ Q +Q K ++ AK+ +Q EE+ + ++K++E E+++ + E +
Sbjct: 454 KIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQ-EEKMRRQEEKIREQEKKIREQEEKIR 512
Query: 301 KEIHNLKQQLELL---EEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
++ +++Q E + EE E E K Q EEK R + + E + R+ Q E +
Sbjct: 513 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKM 567
Score = 61.2 bits (147), Expect = 2e-09
Identities = 72/345 (20%), Positives = 157/345 (45%), Gaps = 68/345 (19%)
Query: 48 AVKKLE-EFQKISHMVIEEVNF---MQNHLEIEKTCRESAEALATKLNKENKTLKRISML 103
AVK+LE E + + + + F ++ L T ++ A+ +L KE L
Sbjct: 140 AVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALS----- 194
Query: 104 YMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKELRDQIV---------SV 154
+L + IT+E + ++++ + Q +KEL+ ++ +
Sbjct: 195 --LELYRNTITDE-ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQL 251
Query: 155 QEEKKILAIELENLKSKLVEVIEE------VNKVKQEKTVLNSEVLEQRKVLEKCNRVSM 208
Q E L EL+++ +KL +EE +N+ ++EK E +++R+
Sbjct: 252 QAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQERE---------- 301
Query: 209 LAVEEYEEMQVNL-ELEKDLRKKAESFAQEMFIEQNKLKRQSHLLLQSSIPDQQLLKALD 267
E+ +E + + E E+ +R++ E M+ ++ K++RQ ++ + ++L + +
Sbjct: 302 ---EKIQEQEEKIREQEEKMRRQEEM----MWEKEEKMRRQEEMMWEKEEKIRELEEKMH 354
Query: 268 ENAKLTQQ----LEEERIQHQQKVKELEEQL--ENETLHKEIHNLKQQLELL-------- 313
E K+ +Q EEE+I+ Q+K +E E ++ + E + ++ +++Q E++
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMG 414
Query: 314 ---------EEDKKELELKYQNSEEKARNLKHSVDELQKRVNQSE 349
EE+ +E E K + EEK R + + E ++++ + E
Sbjct: 415 EQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 459
Score = 54.7 bits (130), Expect = 2e-07
Identities = 46/222 (20%), Positives = 105/222 (47%), Gaps = 12/222 (5%)
Query: 134 TCVSVQCQKQIKELRDQIVSVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEV 193
T + +++ +L++++ V+ EK + + ++ LK KL E K+ + L +E
Sbjct: 201 TITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKL-----ERAKLLLPQQQLQAEA 255
Query: 194 LEQRKVLEKCNRVSMLAVEEYEEM-QVNLELEKDLRKKAESFAQEMFIEQNKLKRQSHLL 252
K L+ + VEE E ++N + E+ + ++ E + + K++ Q +
Sbjct: 256 DHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER----EEKIQEQEEKI 311
Query: 253 LQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLENETLHKEIHNLKQQLEL 312
+ ++ + + E + ++ EE + ++K++ELEE++ + +E +Q+ E
Sbjct: 312 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 371
Query: 313 LEEDKK--ELELKYQNSEEKARNLKHSVDELQKRVNQSENSV 352
+ E +K E E K EEK R + + E ++ + + E +
Sbjct: 372 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKM 413
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.125 0.325
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,646,146
Number of Sequences: 37866
Number of extensions: 1112229
Number of successful extensions: 45643
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1083
Number of HSP's successfully gapped in prelim test: 1435
Number of HSP's that attempted gapping in prelim test: 17672
Number of HSP's gapped (non-prelim): 15409
length of query: 456
length of database: 18,247,518
effective HSP length: 106
effective length of query: 350
effective length of database: 14,233,722
effective search space: 4981802700
effective search space used: 4981802700
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.