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Search of human proteins with 49574532
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]
(483 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens] 981 0.0
gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo sap... 629 e-180
gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo sapi... 620 e-177
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 176 4e-44
gi|27477122 intestinal cell kinase [Homo sapiens] 174 2e-43
gi|7662388 intestinal cell kinase [Homo sapiens] 174 2e-43
gi|11496279 male germ cell-associated kinase [Homo sapiens] 173 3e-43
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 173 4e-43
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 173 4e-43
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 172 6e-43
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 172 6e-43
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 172 6e-43
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 165 7e-41
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 164 1e-40
gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens] 163 3e-40
gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo s... 162 6e-40
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s... 162 6e-40
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 160 3e-39
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 159 4e-39
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 159 4e-39
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 159 4e-39
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 159 7e-39
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 158 9e-39
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens] 157 3e-38
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens] 156 3e-38
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens] 156 3e-38
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 155 6e-38
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 155 6e-38
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 155 6e-38
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 155 6e-38
>gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]
Length = 483
Score = 981 bits (2536), Expect = 0.0
Identities = 483/483 (100%), Positives = 483/483 (100%)
Query: 1 MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV 60
MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
Sbjct: 1 MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV 60
Query: 61 GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT 120
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
Sbjct: 61 GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT 120
Query: 121 DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY 180
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
Sbjct: 121 DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY 180
Query: 181 SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV 240
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
Sbjct: 181 SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV 240
Query: 241 CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS 300
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
Sbjct: 241 CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS 300
Query: 301 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK 360
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
Sbjct: 301 IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK 360
Query: 361 AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP 420
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
Sbjct: 361 AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP 420
Query: 421 PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT 480
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
Sbjct: 421 PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT 480
Query: 481 NSS 483
NSS
Sbjct: 481 NSS 483
>gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo
sapiens]
Length = 420
Score = 629 bits (1622), Expect = e-180
Identities = 312/400 (78%), Positives = 346/400 (86%), Gaps = 1/400 (0%)
Query: 84 TSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE 143
++F V +D KVTTVVAT GQGP+R QEV+YTD KVIGNGSFGVVYQA+L ++ E
Sbjct: 21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGE 80
Query: 144 LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVY 203
LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDE+YLNLVL+YVPETVY
Sbjct: 81 LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 140
Query: 204 RVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCD 263
RVARH+++AK T+P++YVK+YMYQLFRSLAYIHS G+CHRDIKPQNLL+DPDTAVLKLCD
Sbjct: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200
Query: 264 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 323
FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD
Sbjct: 201 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260
Query: 324 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSL 383
SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVF+ RTPPEAIALCS L
Sbjct: 261 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRL 320
Query: 384 LEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPP 443
LEYTP++RL+PLEACAHSFFDELR +LPN R P LFNF+ ELS P L ILIPP
Sbjct: 321 LEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPP 380
Query: 444 HLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS 483
H R A +T T ++ A ++ T Q+ +A ++S
Sbjct: 381 HARIQAAASTPT-NATAASDANTGDRGQTNNAASASASNS 419
>gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo
sapiens]
Length = 433
Score = 620 bits (1598), Expect = e-177
Identities = 312/413 (75%), Positives = 346/413 (83%), Gaps = 14/413 (3%)
Query: 84 TSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE 143
++F V +D KVTTVVAT GQGP+R QEV+YTD KVIGNGSFGVVYQA+L ++ E
Sbjct: 21 SAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGE 80
Query: 144 LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVY 203
LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDE+YLNLVL+YVPETVY
Sbjct: 81 LVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVY 140
Query: 204 RVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCD 263
RVARH+++AK T+P++YVK+YMYQLFRSLAYIHS G+CHRDIKPQNLL+DPDTAVLKLCD
Sbjct: 141 RVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCD 200
Query: 264 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 323
FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD
Sbjct: 201 FGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGD 260
Query: 324 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTK-------------VFKS 370
SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTK VF+
Sbjct: 261 SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRP 320
Query: 371 RTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGEL 430
RTPPEAIALCS LLEYTP++RL+PLEACAHSFFDELR +LPN R P LFNF+ EL
Sbjct: 321 RTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQEL 380
Query: 431 SIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS 483
S P L ILIPPH R A +T T ++ A ++ T Q+ +A ++S
Sbjct: 381 SSNPPLATILIPPHARIQAAASTPT-NATAASDANTGDRGQTNNAASASASNS 432
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 176 bits (446), Expect = 4e-44
Identities = 121/339 (35%), Positives = 181/339 (53%), Gaps = 34/339 (10%)
Query: 113 RSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN---------RELQI 163
+S+ Y + +G G F VY+AR T ++VAIKK+ R + RE+++
Sbjct: 6 KSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKL 65
Query: 164 MRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKV 223
+++L H NI+ L F G K + ++LV +++ + + + + L + ++K
Sbjct: 66 LQELSHPNIIGLLDAF---GHKSN---ISLVFDFMETDLEVIIKDNS---LVLTPSHIKA 116
Query: 224 YMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---I 280
YM + L Y+H + HRD+KP NLL+D + VLKL DFG AK G PN +Y +
Sbjct: 117 YMLMTLQGLEYLHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSF--GSPNRAYTHQV 173
Query: 281 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 340
+R+YRAPEL+FGA Y +D+W+ GC+LAELLL P PGDS +DQL I + LGTPT
Sbjct: 174 VTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPT 233
Query: 341 REQIREM--NPNYTEFK-FPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEA 397
EQ +M P+Y FK FP I H +F S + + L L + P +R++ +A
Sbjct: 234 EEQWPDMCSLPDYVTFKSFPGIPLH---HIF-SAAGDDLLDLIQGLFLFNPCARITATQA 289
Query: 398 CAHSFFDEL--RCLGTQLPN-NRPLPPLFNFSAGELSIQ 433
+F G QLP N P+ L S L+I+
Sbjct: 290 LKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIK 328
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 174 bits (441), Expect = 2e-43
Identities = 101/305 (33%), Positives = 174/305 (57%), Gaps = 20/305 (6%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 173
YT I+ +G+G++G V R E+ EL+AIKK+ + ++ RE++ ++KL+H N+V
Sbjct: 4 YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVV 63
Query: 174 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA 233
+L+ + D LY + EY+ E +Y++ + K P ++ MYQ+ + LA
Sbjct: 64 KLKEVI----RENDHLYF--IFEYMKENLYQLIKERNKL---FPESAIRNIMYQILQGLA 114
Query: 234 YIHSQGVCHRDIKPQNLL-VDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 292
+IH G HRD+KP+NLL + P+ ++K+ DFG A+++ P Y+ +R+YRAPE++
Sbjct: 115 FIHKHGFFHRDLKPENLLCMGPE--LVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLL 172
Query: 293 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--MNPN 350
+T+Y+S IDVW+ GC++AE+ +P+FPG S +D + +I +VLGTP + E +
Sbjct: 173 RSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSS 232
Query: 351 YTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLG 410
F++PQ + K EA+ L +L++ P R + +A + +F LG
Sbjct: 233 AMNFRWPQCVPNN-LKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLG 291
Query: 411 TQLPN 415
+ N
Sbjct: 292 STTQN 296
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 174 bits (441), Expect = 2e-43
Identities = 101/305 (33%), Positives = 174/305 (57%), Gaps = 20/305 (6%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 173
YT I+ +G+G++G V R E+ EL+AIKK+ + ++ RE++ ++KL+H N+V
Sbjct: 4 YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANVV 63
Query: 174 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA 233
+L+ + D LY + EY+ E +Y++ + K P ++ MYQ+ + LA
Sbjct: 64 KLKEVI----RENDHLYF--IFEYMKENLYQLIKERNKL---FPESAIRNIMYQILQGLA 114
Query: 234 YIHSQGVCHRDIKPQNLL-VDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 292
+IH G HRD+KP+NLL + P+ ++K+ DFG A+++ P Y+ +R+YRAPE++
Sbjct: 115 FIHKHGFFHRDLKPENLLCMGPE--LVKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLL 172
Query: 293 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--MNPN 350
+T+Y+S IDVW+ GC++AE+ +P+FPG S +D + +I +VLGTP + E +
Sbjct: 173 RSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSS 232
Query: 351 YTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLG 410
F++PQ + K EA+ L +L++ P R + +A + +F LG
Sbjct: 233 AMNFRWPQCVPNN-LKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLG 291
Query: 411 TQLPN 415
+ N
Sbjct: 292 STTQN 296
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 173 bits (439), Expect = 3e-43
Identities = 108/326 (33%), Positives = 180/326 (55%), Gaps = 21/326 (6%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQ-----DKRFKNRELQIMRKLDHCNIV 173
YT ++ +G+G++G V + E+ ELVAIK++ + D+ RE++ ++KL+H N++
Sbjct: 4 YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVI 63
Query: 174 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA 233
+L+ + D LY + EY+ E +Y++ + K P ++ MYQ+ + LA
Sbjct: 64 KLKEVI----RENDHLYF--IFEYMKENLYQLMKDRNKL---FPESVIRNIMYQILQGLA 114
Query: 234 YIHSQGVCHRDIKPQNLL-VDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 292
+IH G HRD+KP+NLL + P+ ++K+ DFG A++L P Y+ +R+YRAPE++
Sbjct: 115 FIHKHGFFHRDMKPENLLCMGPE--LVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLL 172
Query: 293 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE--MNPN 350
++ Y+S IDVW+ G ++AEL + +P+FPG S VD++ +I +VLGTP + E +
Sbjct: 173 RSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLAS 232
Query: 351 YTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLG 410
F+FPQ K EAI L + +L + P R + +A H +F + LG
Sbjct: 233 SMNFRFPQCVPIN-LKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLG 291
Query: 411 TQLPNNRPLPPLFNFSAGELSIQPSL 436
N+ N L +PSL
Sbjct: 292 PS-SNHLESKQSLNKQLQPLESKPSL 316
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 173 bits (438), Expect = 4e-43
Identities = 107/303 (35%), Positives = 174/303 (57%), Gaps = 32/303 (10%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 172
+ ++ IG G++GVVY+AR T E+VA+KK+ D + RE+ ++++L+H NI
Sbjct: 4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNI 63
Query: 173 VRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSL 232
V+L ++ + L LV E++ + + + A IP+ +K Y++QL + L
Sbjct: 64 VKLLDVIHTENK------LYLVFEFLHQDLKKFMD--ASALTGIPLPLIKSYLFQLLQGL 115
Query: 233 AYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 289
A+ HS V HRD+KPQNLL++ + A+ KL DFG A+ G P +Y + + +YRAPE
Sbjct: 116 AFCHSHRVLHRDLKPQNLLINTEGAI-KLADFGLARAF--GVPVRTYTHEVVTLWYRAPE 172
Query: 290 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR---EQIRE 346
++ G Y++++D+WS GC+ AE++ + +FPGDS +DQL I + LGTP +
Sbjct: 173 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 232
Query: 347 MNPNYTEFKFPQIKAHPWTKVFKSRTPP---EAIALCSSLLEYTPSSRLSPLEACAHSFF 403
M P+Y FP+ ++KV PP + +L S +L Y P+ R+S A AH FF
Sbjct: 233 M-PDYKP-SFPKWARQDFSKV----VPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286
Query: 404 DEL 406
++
Sbjct: 287 QDV 289
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 173 bits (438), Expect = 4e-43
Identities = 100/294 (34%), Positives = 157/294 (53%), Gaps = 19/294 (6%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQD------KRFKNRELQIMRKLDHCNI 172
Y ++ ++G GS+G+V + R +T +VAIKK L+ K+ RE++++++L H N+
Sbjct: 4 YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL 63
Query: 173 VRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSL 232
V L +KK YL V E+V T+ F + V+ Y++Q+ +
Sbjct: 64 VNL----LEVCKKKKRWYL--VFEFVDHTILDDLELFPNG---LDYQVVQKYLFQIINGI 114
Query: 233 AYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELI 291
+ HS + HRDIKP+N+LV + V+KLCDFG A+ L GE Y+ +R+YRAPEL+
Sbjct: 115 GFCHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELL 173
Query: 292 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGT--PTREQIREMNP 349
G Y ++DVW+ GC++ E+ +G+P+FPGDS +DQL I+ LG P +++ NP
Sbjct: 174 VGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNP 233
Query: 350 NYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF 403
+ + P+IK + + I L L P R E H FF
Sbjct: 234 VFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 287
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 172 bits (436), Expect = 6e-43
Identities = 104/298 (34%), Positives = 171/298 (57%), Gaps = 28/298 (9%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 172
+ ++ IG G++GVVY+A+ ET +LVA+KK+ D + RE+ ++++L H NI
Sbjct: 4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNI 63
Query: 173 VRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSL 232
VRL ++ E L LV E++ + + + ++L P+ +K Y++QL + +
Sbjct: 64 VRLLDVVHN------ERKLYLVFEFLSQDLKKYMDSTPGSEL--PLHLIKSYLFQLLQGV 115
Query: 233 AYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 289
++ HS V HRD+KPQNLL++ + +KL DFG A+ G P +Y + + +YRAPE
Sbjct: 116 SFCHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLARAF--GVPLRTYTHEVVTLWYRAPE 172
Query: 290 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 349
++ G+ YT+++D+WS GC+ AE++ + +FPGDS +DQL I ++LGTP+ + P
Sbjct: 173 ILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTW----P 228
Query: 350 NYTEFKFPQIKAHPWT-KVFKSRTP---PEAIALCSSLLEYTPSSRLSPLEACAHSFF 403
T+ + WT K + P PE L LL+Y PS R++ A AH +F
Sbjct: 229 GVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 172 bits (436), Expect = 6e-43
Identities = 111/298 (37%), Positives = 161/298 (54%), Gaps = 24/298 (8%)
Query: 124 VIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRY 177
V+G G++GVV + R ET E+VAIKK + + REL+++R L NIV L+
Sbjct: 18 VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKE 77
Query: 178 FFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHS 237
F G+ L LV EYV + + + +P VK Y+YQL +++ + H
Sbjct: 78 AFRRRGK------LYLVFEYVEKNMLELLEEMPNG---VPPEKVKSYIYQLIKAIHWCHK 128
Query: 238 QGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN--VSYICSRYYRAPELIFGAT 295
+ HRDIKP+NLL+ + VLKLCDFG A+ L G Y+ +R+YR+PEL+ GA
Sbjct: 129 NDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP 187
Query: 296 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--EMNPNYTE 353
Y S+D+WS GC+L EL GQP+FPG+S +DQL I KVLG EQ++ NP +
Sbjct: 188 -YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246
Query: 354 FKFPQIKAHPWT--KVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCL 409
+FP + HP + + + + L +LL+ P+ R + H F R L
Sbjct: 247 LRFPAVN-HPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL 303
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 172 bits (436), Expect = 6e-43
Identities = 111/298 (37%), Positives = 161/298 (54%), Gaps = 24/298 (8%)
Query: 124 VIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN------RELQIMRKLDHCNIVRLRY 177
V+G G++GVV + R ET E+VAIKK + + REL+++R L NIV L+
Sbjct: 18 VVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKE 77
Query: 178 FFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHS 237
F G+ L LV EYV + + + +P VK Y+YQL +++ + H
Sbjct: 78 AFRRRGK------LYLVFEYVEKNMLELLEEMPNG---VPPEKVKSYIYQLIKAIHWCHK 128
Query: 238 QGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN--VSYICSRYYRAPELIFGAT 295
+ HRDIKP+NLL+ + VLKLCDFG A+ L G Y+ +R+YR+PEL+ GA
Sbjct: 129 NDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP 187
Query: 296 DYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIR--EMNPNYTE 353
Y S+D+WS GC+L EL GQP+FPG+S +DQL I KVLG EQ++ NP +
Sbjct: 188 -YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246
Query: 354 FKFPQIKAHPWT--KVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCL 409
+FP + HP + + + + L +LL+ P+ R + H F R L
Sbjct: 247 LRFPAVN-HPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLL 303
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 165 bits (418), Expect = 7e-41
Identities = 104/299 (34%), Positives = 161/299 (53%), Gaps = 21/299 (7%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQD------KRFKNRELQIMRKLDHCNI 172
Y I IG GS+GVV++ R +T ++VAIKK L+ K+ RE++++++L H N+
Sbjct: 5 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNL 64
Query: 173 VRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSL 232
V L F + + L+LV EY TV + + +P VK +Q +++
Sbjct: 65 VNLLEVF------RRKRRLHLVFEYCDHTVLHELDRYQRG---VPEHLVKSITWQTLQAV 115
Query: 233 AYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVR-GEPNVSYICSRYYRAPELI 291
+ H HRD+KP+N+L+ + V+KLCDFG A+ L + Y+ +R+YR+PEL+
Sbjct: 116 NFCHKHNCIHRDVKPENILITKHS-VIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELL 174
Query: 292 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNP 349
G T Y +DVW+ GCV AELL G P++PG S VDQL I K LG P +Q+ N
Sbjct: 175 VGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQ 234
Query: 350 NYTEFKFPQIK-AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELR 407
++ K P + P F + + P A+ L L P+ RL+ + H +F+ +R
Sbjct: 235 YFSGVKIPDPEDMEPLELKFPNISYP-ALGLLKGCLHMDPTQRLTCEQLLHHPYFENIR 292
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 164 bits (416), Expect = 1e-40
Identities = 111/303 (36%), Positives = 168/303 (55%), Gaps = 34/303 (11%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 172
Y ++ IG G++G V++A+ ET E+VA+K+V D + RE+ ++++L H NI
Sbjct: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Query: 173 VRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSL 232
VRL +S +KK L LV E+ + + ++F + VK +++QL + L
Sbjct: 64 VRLHDVLHS--DKK----LTLVFEFCDQDL---KKYFDSCNGDLDPEIVKSFLFQLLKGL 114
Query: 233 AYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 289
+ HS+ V HRD+KPQNLL++ + LKL DFG A+ G P Y + + +YR P+
Sbjct: 115 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPD 171
Query: 290 LIFGATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN 348
++FGA Y++SID+WSAGC+ AEL G+P+FPG+ DQL I ++LGTPT EQ M
Sbjct: 172 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 231
Query: 349 PNYTEFKFPQIKAHPWTKVFKS--RTPPEAIA----LCSSLLEYTPSSRLSPLEACAHSF 402
K P K +P S P+ A L +LL+ P R+S EA H +
Sbjct: 232 ------KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPY 285
Query: 403 FDE 405
F +
Sbjct: 286 FSD 288
>gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
Length = 315
Score = 163 bits (413), Expect = 3e-40
Identities = 96/297 (32%), Positives = 157/297 (52%), Gaps = 18/297 (6%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQD------KRFKNRELQIMRKLDHCNI 172
Y + G GS+GVV++ R + ++VA+KK ++ K+ RE++++++L H N+
Sbjct: 4 YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNL 63
Query: 173 VRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSL 232
V L F + + ++LV EY T+ + +K ++Q ++L
Sbjct: 64 VNLIEVF------RRKRKMHLVFEYCDHTLLNELERNPNG---VADGVIKSVLWQTLQAL 114
Query: 233 AYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIF 292
+ H HRDIKP+N+L+ ++K+CDFG A+ L+ G+ Y+ +R+YRAPEL+
Sbjct: 115 NFCHIHNCIHRDIKPENILITKQ-GIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLV 173
Query: 293 GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLG--TPTREQIREMNPN 350
G T Y SS+D+W+ GCV AELL GQP++PG S VDQL II+ LG P + I + N
Sbjct: 174 GDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGF 233
Query: 351 YTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELR 407
+ P+ + + S P A+ L+ P RL+ + S+FD +
Sbjct: 234 FHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQ 290
>gi|91718897 mitogen-activated protein kinase 3 isoform 2 [Homo
sapiens]
Length = 357
Score = 162 bits (410), Expect = 6e-40
Identities = 111/345 (32%), Positives = 181/345 (52%), Gaps = 34/345 (9%)
Query: 75 GGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVY 134
GG GG T PGV G+V V +G YT ++ IG G++G+V
Sbjct: 8 GGGGGEPRRTEGVGPGVP-----GEVEMV-----KGQPFDVGPRYTQLQYIGEGAYGMVS 57
Query: 135 QARLAETRELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDE 188
A + VAIKK+ + + + R E+QI+ + H N++ +R +S E +
Sbjct: 58 SAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRD 117
Query: 189 LYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQ 248
+Y+ V + + +Y++ + + ++ ++YQ+ R L YIHS V HRD+KP
Sbjct: 118 VYI--VQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPS 170
Query: 249 NLLVDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSRYYRAPELIFGATDYTSSIDVW 304
NLL++ T LK+CDFG A+ + Y+ +R+YRAPE++ + YT SID+W
Sbjct: 171 NLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW 229
Query: 305 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ----IREMNPNYTEFKFPQIK 360
S GC+LAE+L +PIFPG +DQL I+ +LG+P++E I NY + P
Sbjct: 230 SVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ-SLPSKT 288
Query: 361 AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDE 405
W K+F ++ +A+ L +L + P+ R++ EA AH + ++
Sbjct: 289 KVAWAKLF-PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332
>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
sapiens]
Length = 379
Score = 162 bits (410), Expect = 6e-40
Identities = 111/345 (32%), Positives = 181/345 (52%), Gaps = 34/345 (9%)
Query: 75 GGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVY 134
GG GG T PGV G+V V +G YT ++ IG G++G+V
Sbjct: 8 GGGGGEPRRTEGVGPGVP-----GEVEMV-----KGQPFDVGPRYTQLQYIGEGAYGMVS 57
Query: 135 QARLAETRELVAIKKV--LQDKRFKNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDE 188
A + VAIKK+ + + + R E+QI+ + H N++ +R +S E +
Sbjct: 58 SAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRD 117
Query: 189 LYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQ 248
+Y+ V + + +Y++ + + ++ ++YQ+ R L YIHS V HRD+KP
Sbjct: 118 VYI--VQDLMETDLYKLLK-----SQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPS 170
Query: 249 NLLVDPDTAVLKLCDFGSAKQLVRGEPNVS----YICSRYYRAPELIFGATDYTSSIDVW 304
NLL++ T LK+CDFG A+ + Y+ +R+YRAPE++ + YT SID+W
Sbjct: 171 NLLINT-TCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIW 229
Query: 305 SAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQ----IREMNPNYTEFKFPQIK 360
S GC+LAE+L +PIFPG +DQL I+ +LG+P++E I NY + P
Sbjct: 230 SVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQ-SLPSKT 288
Query: 361 AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDE 405
W K+F ++ +A+ L +L + P+ R++ EA AH + ++
Sbjct: 289 KVAWAKLF-PKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 332
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 160 bits (404), Expect = 3e-39
Identities = 110/346 (31%), Positives = 177/346 (51%), Gaps = 37/346 (10%)
Query: 125 IGNGSFGVVYQARLAETRELVAIKKV----LQDKRFKNRELQIMRKL----DHCNIVRLR 176
IG G+ G+V++A+ ET E+VA+KKV L+D F N+ L+ ++ L D+ +V+L+
Sbjct: 10 IGEGAHGIVFKAKHVETGEIVALKKVALRRLEDG-FPNQALREIKALQEMEDNQYVVQLK 68
Query: 177 YFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIH 236
F G L E++ + V RH A+ + VK Y+ L + +A+ H
Sbjct: 69 AVFPHGGG------FVLAFEFMLSDLAEVVRH---AQRPLAQAQVKSYLQMLLKGVAFCH 119
Query: 237 SQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNV--SYICSRYYRAPELIFGA 294
+ + HRD+KP NLL+ + LK+ DFG A+ + + +R+YRAPEL++GA
Sbjct: 120 ANNIVHRDLKPANLLISA-SGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGA 178
Query: 295 TDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN--PNYT 352
Y +D+WS GC++ ELL G P+FPG + ++QL ++++LGTP + E+ P+Y
Sbjct: 179 RQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYN 238
Query: 353 EFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF--------- 403
+ F + P +V P+A+ L L Y P R++ +A H +F
Sbjct: 239 KISFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHP 297
Query: 404 DEL---RCLGTQLPNNRPLPP-LFNFSAGELSIQPSLNAILIPPHL 445
EL + LG P P PP + +F + LN LI P +
Sbjct: 298 SELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFI 343
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 159 bits (403), Expect = 4e-39
Identities = 107/340 (31%), Positives = 172/340 (50%), Gaps = 26/340 (7%)
Query: 83 GTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVA------YTDIKVIGNGSFGVVYQA 136
G++ PP VK + L RS +V Y I+ IGNG++GVV A
Sbjct: 13 GSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSA 72
Query: 137 RLAETRELVAIKK------VLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELY 190
R T + VAIKK V+ + + REL+I++ H NI+ ++ + +
Sbjct: 73 RRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKS 132
Query: 191 LNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNL 250
+ +VL+ + ++++ + + + +V+ ++YQL R L Y+HS V HRD+KP NL
Sbjct: 133 VYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNL 188
Query: 251 LVDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRAPELIFGATDYTSSIDVWS 305
LV+ + LK+ DFG A+ L Y+ +R+YRAPEL+ +YT +ID+WS
Sbjct: 189 LVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWS 247
Query: 306 AGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF---KFPQIKAH 362
GC+ E+L + +FPG + V QL I+ VLGTP+ I+ + P +
Sbjct: 248 VGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPV 307
Query: 363 PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSF 402
PW V+ +A++L +L + PS+R+S A H F
Sbjct: 308 PWETVYPG-ADRQALSLLGRMLRFEPSARISAAAALRHPF 346
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 159 bits (403), Expect = 4e-39
Identities = 107/340 (31%), Positives = 172/340 (50%), Gaps = 26/340 (7%)
Query: 83 GTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVA------YTDIKVIGNGSFGVVYQA 136
G++ PP VK + L RS +V Y I+ IGNG++GVV A
Sbjct: 13 GSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSA 72
Query: 137 RLAETRELVAIKK------VLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELY 190
R T + VAIKK V+ + + REL+I++ H NI+ ++ + +
Sbjct: 73 RRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKS 132
Query: 191 LNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNL 250
+ +VL+ + ++++ + + + +V+ ++YQL R L Y+HS V HRD+KP NL
Sbjct: 133 VYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNL 188
Query: 251 LVDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRAPELIFGATDYTSSIDVWS 305
LV+ + LK+ DFG A+ L Y+ +R+YRAPEL+ +YT +ID+WS
Sbjct: 189 LVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWS 247
Query: 306 AGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF---KFPQIKAH 362
GC+ E+L + +FPG + V QL I+ VLGTP+ I+ + P +
Sbjct: 248 VGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPV 307
Query: 363 PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSF 402
PW V+ +A++L +L + PS+R+S A H F
Sbjct: 308 PWETVYPG-ADRQALSLLGRMLRFEPSARISAAAALRHPF 346
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 159 bits (403), Expect = 4e-39
Identities = 107/340 (31%), Positives = 172/340 (50%), Gaps = 26/340 (7%)
Query: 83 GTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVA------YTDIKVIGNGSFGVVYQA 136
G++ PP VK + L RS +V Y I+ IGNG++GVV A
Sbjct: 13 GSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSA 72
Query: 137 RLAETRELVAIKK------VLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELY 190
R T + VAIKK V+ + + REL+I++ H NI+ ++ + +
Sbjct: 73 RRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKS 132
Query: 191 LNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNL 250
+ +VL+ + ++++ + + + +V+ ++YQL R L Y+HS V HRD+KP NL
Sbjct: 133 VYVVLDLMESDLHQIIH----SSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNL 188
Query: 251 LVDPDTAVLKLCDFGSAKQLVRGEPN-----VSYICSRYYRAPELIFGATDYTSSIDVWS 305
LV+ + LK+ DFG A+ L Y+ +R+YRAPEL+ +YT +ID+WS
Sbjct: 189 LVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWS 247
Query: 306 AGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF---KFPQIKAH 362
GC+ E+L + +FPG + V QL I+ VLGTP+ I+ + P +
Sbjct: 248 VGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPV 307
Query: 363 PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSF 402
PW V+ +A++L +L + PS+R+S A H F
Sbjct: 308 PWETVYPG-ADRQALSLLGRMLRFEPSARISAAAALRHPF 346
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 159 bits (401), Expect = 7e-39
Identities = 106/336 (31%), Positives = 174/336 (51%), Gaps = 31/336 (9%)
Query: 118 AYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKR-----FKNRELQIMRKLDHCNI 172
+Y +++ +G GS+ VY+ +LVA+K + + RE +++ L H NI
Sbjct: 51 SYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANI 110
Query: 173 VRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSL 232
V L ++ L V EY+ + A++ ++ + V+++M+QL R L
Sbjct: 111 VLLHDIIHTKET------LTFVFEYMHTDL---AQYMSQHPGGLHPHNVRLFMFQLLRGL 161
Query: 233 AYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAK-QLVRGEPNVSYICSRYYRAPELI 291
AYIH Q V HRD+KPQNLL+ LKL DFG A+ + + + S + + +YR P+ +
Sbjct: 162 AYIHHQHVLHRDLKPQNLLIS-HLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDAL 220
Query: 292 FGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGV-DQLVEIIKVLGTPTRE------QI 344
GAT+Y+S +D+W AGC+ E+ GQP+FPG S + +QL +I +VLG PT + ++
Sbjct: 221 LGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKL 280
Query: 345 REMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFD 404
NP + P+ W ++ + PEA L S +L+ P R+S EA H +F
Sbjct: 281 PNYNPEWFPLPTPRSLHVVWNRLGR---VPEAEDLASQMLKGFPRDRVSAQEALVHDYFS 337
Query: 405 ELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAIL 440
L QLP+ L F+ + ++P + +L
Sbjct: 338 ALPSQLYQLPDEESL-----FTVSGVRLKPEMCDLL 368
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 158 bits (400), Expect = 9e-39
Identities = 103/326 (31%), Positives = 172/326 (52%), Gaps = 30/326 (9%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKR-----FKNRELQIMRKLDHCNIV 173
Y ++ +G G++ VY+ R T LVA+K++ + RE+ +++ L H NIV
Sbjct: 192 YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIV 251
Query: 174 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA 233
L ++ L LV EY+ + + ++ + + VK+++YQ+ R LA
Sbjct: 252 TLHDIVHTDKS------LTLVFEYLDKDL---KQYMDDCGNIMSMHNVKLFLYQILRGLA 302
Query: 234 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPEL 290
Y H + V HRD+KPQNLL++ + LKL DFG A+ + P +Y + + +YR P++
Sbjct: 303 YCHRRKVLHRDLKPQNLLIN-EKGELKLADFGLAR--AKSVPTKTYSNEVVTLWYRPPDV 359
Query: 291 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPN 350
+ G+++Y++ ID+W GC+ E+ G+P+FPG + D+L I ++LGTP++E ++ N
Sbjct: 360 LLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSN 419
Query: 351 --YTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRC 408
+ + FP+ K P R E I L + L+Y R+S EA H +F R
Sbjct: 420 EEFKNYNFPKYKPQPLIN-HAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYF---RS 475
Query: 409 LGTQLPNNRPLPPLFN-FSAGELSIQ 433
LG P LP + FS E+ +Q
Sbjct: 476 LG---PRIHALPESVSIFSLKEIQLQ 498
>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
Length = 364
Score = 157 bits (396), Expect = 3e-38
Identities = 98/309 (31%), Positives = 165/309 (53%), Gaps = 23/309 (7%)
Query: 106 TLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKV------LQDKRFKNR 159
T+ + P+R Q ++ +G+G++G V A A R+ VA+KK+ L R R
Sbjct: 16 TVWEVPQRLQ-----GLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR 70
Query: 160 ELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIL 219
EL++++ L H N++ L F + +D + LV + + + + +
Sbjct: 71 ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-----QALSDE 125
Query: 220 YVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY 279
+V+ +YQL R L YIHS G+ HRD+KP N+ V+ D L++ DFG A+Q E Y
Sbjct: 126 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCE-LRILDFGLARQA--DEEMTGY 182
Query: 280 ICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTP 339
+ +R+YRAPE++ Y ++D+WS GC++AELL G+ +FPG +DQL I++V+GTP
Sbjct: 183 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP 242
Query: 340 TREQIREMNPNYTEF---KFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLE 396
+ E + +++ + P + + +F+ P AI L +L R+S E
Sbjct: 243 SPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-PLAIDLLGRMLVLDSDQRVSAAE 301
Query: 397 ACAHSFFDE 405
A AH++F +
Sbjct: 302 ALAHAYFSQ 310
>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 156 bits (395), Expect = 3e-38
Identities = 103/320 (32%), Positives = 170/320 (53%), Gaps = 28/320 (8%)
Query: 105 ATLGQGPE--RSQEV----AYTDIKVIGNGSFGVVYQARLAETRELVAIKKV--LQDKRF 156
A G GPE R Q YT++ IG G++G+V A + VAIKK+ + + +
Sbjct: 5 AAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTY 64
Query: 157 KNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFTKA 212
R E++I+ + H NI+ + + E+ ++Y+ V + + +Y++ + T+
Sbjct: 65 CQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI--VQDLMETDLYKLLK--TQH 120
Query: 213 KLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVR 272
I Y ++YQ+ R L YIHS V HRD+KP NLL++ T LK+CDFG A+
Sbjct: 121 LSNDHICY---FLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARVADP 176
Query: 273 GEPNVS----YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ 328
+ Y+ +R+YRAPE++ + YT SID+WS GC+LAE+L +PIFPG +DQ
Sbjct: 177 DHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ 236
Query: 329 LVEIIKVLGTPTREQIR---EMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLE 385
L I+ +LG+P++E + + P PW ++F + +A+ L +L
Sbjct: 237 LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPN-ADSKALDLLDKMLT 295
Query: 386 YTPSSRLSPLEACAHSFFDE 405
+ P R+ +A AH + ++
Sbjct: 296 FNPHKRIEVEQALAHPYLEQ 315
>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
Length = 360
Score = 156 bits (395), Expect = 3e-38
Identities = 103/320 (32%), Positives = 170/320 (53%), Gaps = 28/320 (8%)
Query: 105 ATLGQGPE--RSQEV----AYTDIKVIGNGSFGVVYQARLAETRELVAIKKV--LQDKRF 156
A G GPE R Q YT++ IG G++G+V A + VAIKK+ + + +
Sbjct: 5 AAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTY 64
Query: 157 KNR---ELQIMRKLDHCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFTKA 212
R E++I+ + H NI+ + + E+ ++Y+ V + + +Y++ + T+
Sbjct: 65 CQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI--VQDLMETDLYKLLK--TQH 120
Query: 213 KLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVR 272
I Y ++YQ+ R L YIHS V HRD+KP NLL++ T LK+CDFG A+
Sbjct: 121 LSNDHICY---FLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARVADP 176
Query: 273 GEPNVS----YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ 328
+ Y+ +R+YRAPE++ + YT SID+WS GC+LAE+L +PIFPG +DQ
Sbjct: 177 DHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQ 236
Query: 329 LVEIIKVLGTPTREQIR---EMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLE 385
L I+ +LG+P++E + + P PW ++F + +A+ L +L
Sbjct: 237 LNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPN-ADSKALDLLDKMLT 295
Query: 386 YTPSSRLSPLEACAHSFFDE 405
+ P R+ +A AH + ++
Sbjct: 296 FNPHKRIEVEQALAHPYLEQ 315
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 155 bits (393), Expect = 6e-38
Identities = 100/299 (33%), Positives = 161/299 (53%), Gaps = 23/299 (7%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKN------RELQIMRKLDHCNI 172
YT I+ IG G++GVVY+ R T ++VA+KK+ + + RE+ ++++L H NI
Sbjct: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63
Query: 173 VRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSL 232
V L+ L L+ E++ + + + L VK Y+YQ+ + +
Sbjct: 64 VSLQDVLMQDSR------LYLIFEFLSMDLKKYLDSIPPGQYMDSSL-VKSYLYQILQGI 116
Query: 233 AYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPE 289
+ HS+ V HRD+KPQNLL+D D +KL DFG A+ G P Y + + +YR+PE
Sbjct: 117 VFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPE 173
Query: 290 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNP 349
++ G+ Y++ +D+WS G + AEL +P+F GDS +DQL I + LGTP E E+
Sbjct: 174 VLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE- 232
Query: 350 NYTEFK--FPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDEL 406
+ ++K FP+ K K+ + L S +L Y P+ R+S A H +F++L
Sbjct: 233 SLQDYKNTFPKWKPGSLASHVKN-LDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 290
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 155 bits (393), Expect = 6e-38
Identities = 101/331 (30%), Positives = 167/331 (50%), Gaps = 26/331 (7%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKR-----FKNRELQIMRKLDHCNIV 173
Y + +G G++ V++ R T LVA+K++ + RE+ +++ L H NIV
Sbjct: 174 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIV 233
Query: 174 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA 233
L ++ L LV EY+ + + H + + VK++M+QL R LA
Sbjct: 234 TLHDLIHTDRS------LTLVFEYLDSDLKQYLDHCGNL---MSMHNVKIFMFQLLRGLA 284
Query: 234 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPEL 290
Y H + + HRD+KPQNLL++ + LKL DFG A+ + P +Y + + +YR P++
Sbjct: 285 YCHHRKILHRDLKPQNLLIN-ERGELKLADFGLAR--AKSVPTKTYSNEVVTLWYRPPDV 341
Query: 291 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-- 348
+ G+T+Y++ ID+W GC+ E+ G+P+FPG + ++L I ++LGTPT E +
Sbjct: 342 LLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAF 401
Query: 349 PNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRC 408
+ + FP P R + I L SSLL Y SR+S A +HS+F R
Sbjct: 402 SEFRTYSFPCYLPQPLIN-HAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF---RS 457
Query: 409 LGTQLPNNRPLPPLFNFSAGELSIQPSLNAI 439
LG ++ +F+ +L P +
Sbjct: 458 LGERVHQLEDTASIFSLKEIQLQKDPGYRGL 488
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 155 bits (393), Expect = 6e-38
Identities = 101/331 (30%), Positives = 167/331 (50%), Gaps = 26/331 (7%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKR-----FKNRELQIMRKLDHCNIV 173
Y + +G G++ V++ R T LVA+K++ + RE+ +++ L H NIV
Sbjct: 144 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIV 203
Query: 174 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA 233
L ++ L LV EY+ + + H + + VK++M+QL R LA
Sbjct: 204 TLHDLIHTDRS------LTLVFEYLDSDLKQYLDHCGNL---MSMHNVKIFMFQLLRGLA 254
Query: 234 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPEL 290
Y H + + HRD+KPQNLL++ + LKL DFG A+ + P +Y + + +YR P++
Sbjct: 255 YCHHRKILHRDLKPQNLLIN-ERGELKLADFGLAR--AKSVPTKTYSNEVVTLWYRPPDV 311
Query: 291 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-- 348
+ G+T+Y++ ID+W GC+ E+ G+P+FPG + ++L I ++LGTPT E +
Sbjct: 312 LLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAF 371
Query: 349 PNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRC 408
+ + FP P R + I L SSLL Y SR+S A +HS+F R
Sbjct: 372 SEFRTYSFPCYLPQPLIN-HAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF---RS 427
Query: 409 LGTQLPNNRPLPPLFNFSAGELSIQPSLNAI 439
LG ++ +F+ +L P +
Sbjct: 428 LGERVHQLEDTASIFSLKEIQLQKDPGYRGL 458
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 155 bits (393), Expect = 6e-38
Identities = 101/331 (30%), Positives = 167/331 (50%), Gaps = 26/331 (7%)
Query: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKR-----FKNRELQIMRKLDHCNIV 173
Y + +G G++ V++ R T LVA+K++ + RE+ +++ L H NIV
Sbjct: 144 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIV 203
Query: 174 RLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLA 233
L ++ L LV EY+ + + H + + VK++M+QL R LA
Sbjct: 204 TLHDLIHTDRS------LTLVFEYLDSDLKQYLDHCGNL---MSMHNVKIFMFQLLRGLA 254
Query: 234 YIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSY---ICSRYYRAPEL 290
Y H + + HRD+KPQNLL++ + LKL DFG A+ + P +Y + + +YR P++
Sbjct: 255 YCHHRKILHRDLKPQNLLIN-ERGELKLADFGLAR--AKSVPTKTYSNEVVTLWYRPPDV 311
Query: 291 IFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMN-- 348
+ G+T+Y++ ID+W GC+ E+ G+P+FPG + ++L I ++LGTPT E +
Sbjct: 312 LLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAF 371
Query: 349 PNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRC 408
+ + FP P R + I L SSLL Y SR+S A +HS+F R
Sbjct: 372 SEFRTYSFPCYLPQPLIN-HAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF---RS 427
Query: 409 LGTQLPNNRPLPPLFNFSAGELSIQPSLNAI 439
LG ++ +F+ +L P +
Sbjct: 428 LGERVHQLEDTASIFSLKEIQLQKDPGYRGL 458
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,605,126
Number of Sequences: 37866
Number of extensions: 1539712
Number of successful extensions: 54374
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1334
Number of HSP's successfully gapped in prelim test: 758
Number of HSP's that attempted gapping in prelim test: 11480
Number of HSP's gapped (non-prelim): 17160
length of query: 483
length of database: 18,247,518
effective HSP length: 106
effective length of query: 377
effective length of database: 14,233,722
effective search space: 5366113194
effective search space used: 5366113194
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.