BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like [Homo sapiens] (303 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 628 e-180 gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 345 2e-95 gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 231 6e-61 gi|5729856 GRB2-related adaptor protein [Homo sapiens] 89 4e-18 gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 72 5e-13 gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 72 6e-13 gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 69 5e-12 gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 69 5e-12 gi|11321634 CD2-associated protein [Homo sapiens] 65 1e-10 gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 63 3e-10 gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 60 2e-09 gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 60 2e-09 gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 60 2e-09 gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 59 4e-09 gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 59 4e-09 gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 59 4e-09 gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 59 4e-09 gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 59 4e-09 gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 59 7e-09 gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 59 7e-09 gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 58 9e-09 gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 58 9e-09 gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 58 9e-09 gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 58 9e-09 gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 58 9e-09 gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 58 9e-09 gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 58 9e-09 gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 58 9e-09 gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 58 1e-08 gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 58 1e-08 >gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like [Homo sapiens] Length = 303 Score = 628 bits (1620), Expect = e-180 Identities = 303/303 (100%), Positives = 303/303 (100%) Query: 1 MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH 60 MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH Sbjct: 1 MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH 60 Query: 61 YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT 120 YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT Sbjct: 61 YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT 120 Query: 121 AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180 AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK Sbjct: 121 AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180 Query: 181 LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA 240 LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA Sbjct: 181 LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA 240 Query: 241 KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD 300 KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD Sbjct: 241 KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD 300 Query: 301 ENE 303 ENE Sbjct: 301 ENE 303 >gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a [Homo sapiens] Length = 304 Score = 345 bits (886), Expect = 2e-95 Identities = 184/323 (56%), Positives = 217/323 (67%), Gaps = 45/323 (13%) Query: 3 SARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYI 62 + FDS +RS+WY G +SRQEA LQGQRHG+FLVRDSST PGDYVLSVSENSRVSHYI Sbjct: 2 AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYI 61 Query: 63 INSLPNR-----------------RFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY 105 INS R R +IGDQEFD LPALLEFYKIHYLDTTTLIEP R Sbjct: 62 INSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR- 120 Query: 106 PSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN 165 S + ++ EYVR L+DF GND EDLPFKKG+IL I +KPEEQWW+A + Sbjct: 121 ------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174 Query: 166 KDGRVGMIPVPYVEKLVRSSPH------GKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAV 219 +G+ GMIPVPYVEK +S G + G PEP YAQP TPLP Sbjct: 175 SEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPG-PYAQPSVNTPLP-- 231 Query: 220 SGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEV 279 + QNGP++A+ IQKRVP AYDKTALALEVG++VKVT++N++GQWEGE Sbjct: 232 ------------NLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGEC 279 Query: 280 NGRKGLFPFTHVKIFDPQNPDEN 302 NG++G FPFTHV++ D QNPDE+ Sbjct: 280 NGKRGHFPFTHVRLLDQQNPDED 302 >gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b [Homo sapiens] Length = 204 Score = 231 bits (589), Expect = 6e-61 Identities = 121/195 (62%), Positives = 137/195 (70%), Gaps = 24/195 (12%) Query: 3 SARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYI 62 + FDS +RS+WY G +SRQEA LQGQRHG+FLVRDSST PGDYVLSVSENSRVSHYI Sbjct: 2 AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYI 61 Query: 63 INSLPNR-----------------RFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY 105 INS R R +IGDQEFD LPALLEFYKIHYLDTTTLIEP R Sbjct: 62 INSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR- 120 Query: 106 PSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN 165 S + ++ EYVR L+DF GND EDLPFKKG+IL I +KPEEQWW+A + Sbjct: 121 ------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174 Query: 166 KDGRVGMIPVPYVEK 180 +G+ GMIPVPYVEK Sbjct: 175 SEGKRGMIPVPYVEK 189 >gi|5729856 GRB2-related adaptor protein [Homo sapiens] Length = 217 Score = 89.4 bits (220), Expect = 4e-18 Identities = 48/167 (28%), Positives = 90/167 (53%), Gaps = 14/167 (8%) Query: 14 WYMGPVSRQEAQTRLQGQRH-GMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFK 72 WY G +SRQ A+ L + H G FL+R+S + PG++ +SV+ +V H+ + + ++ Sbjct: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYF 119 Query: 73 IGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLY 132 + +++F+ L L++FY+ TTT+ + + + +P + + + Sbjct: 120 LWEEKFNSLNELVDFYR-----TTTIAKKRQIFLRDEEPLLKSPGAC-------FAQAQF 167 Query: 133 DFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVE 179 DF D L F++G+I+ ++E+P+ WW R+ GRVG P YV+ Sbjct: 168 DFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRS-CGRVGFFPRSYVQ 213 Score = 38.5 bits (88), Expect = 0.007 Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 4/65 (6%) Query: 131 LYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKH 190 LY F ++++L F KG+ L I+ ++Q W G G IP Y +R PH + Sbjct: 6 LYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNY----IRVKPHPWY 61 Query: 191 GNRNS 195 R S Sbjct: 62 SGRIS 66 Score = 30.0 bits (66), Expect = 2.6 Identities = 15/43 (34%), Positives = 22/43 (51%) Query: 250 AYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVK 292 A D + L+ GDI++V W G GR G FP ++V+ Sbjct: 171 AQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQ 213 >gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] Length = 845 Score = 72.4 bits (176), Expect = 5e-13 Identities = 49/170 (28%), Positives = 79/170 (46%), Gaps = 4/170 (2%) Query: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73 WY GP+ R A++ L + G FLVR ++ +S+ N V H I + Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRIT 730 Query: 74 GDQEFDHLPALLEFYKIHYL-DTTTLIEPAPRYP--SPPMGSVSAPNLPTAEDNLEYVRT 130 + F L L+EFY+ + L D ++ ++P P ++S P + + + + Sbjct: 731 EKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTK-YFGTAKA 789 Query: 131 LYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180 YDF D +L K+G+I+ I+ K +Q W GRVG P YVE+ Sbjct: 790 RYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEE 839 Score = 42.7 bits (99), Expect = 4e-04 Identities = 22/63 (34%), Positives = 35/63 (55%), Gaps = 1/63 (1%) Query: 231 PSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFT 289 P+ + F A + CA D++ L+L+ GDI+K+ + G W GE+ GR G FP Sbjct: 776 PAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPAN 835 Query: 290 HVK 292 +V+ Sbjct: 836 YVE 838 >gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo sapiens] Length = 217 Score = 72.0 bits (175), Expect = 6e-13 Identities = 45/177 (25%), Positives = 84/177 (47%), Gaps = 26/177 (14%) Query: 14 WYMGPVSRQEAQTRLQGQRH-GMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFK 72 W+ G + R +A+ L QRH G FL+R+S + PGD+ LSV + V H+ + ++ Sbjct: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119 Query: 73 IGDQEFDHLPALLEFYKIHYLDTTTLI-----EPAPRYPSPPMGSVSAPNLPTAEDNLEY 127 + +F+ L L+++++ + I E P+ P+ Y Sbjct: 120 LWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPT-------------------Y 160 Query: 128 VRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRS 184 V+ L+DF + +L F++G+ + +++ + WW G+ GM P YV + R+ Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA-CHGQTGMFPRNYVTPVNRN 216 Score = 39.7 bits (91), Expect = 0.003 Identities = 17/48 (35%), Positives = 28/48 (58%) Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVE 179 YDF ++L FK+G+IL ++ + +Q W +G+ G IP Y+E Sbjct: 7 YDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54 >gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 [Homo sapiens] Length = 287 Score = 68.9 bits (167), Expect = 5e-12 Identities = 51/175 (29%), Positives = 78/175 (44%), Gaps = 9/175 (5%) Query: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73 WY G + R +A+T L + + +LVR + G+Y +S+ N+ H I + Sbjct: 112 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 171 Query: 74 GDQEFDHLPALLEFYKIHYLDT------TTLIEP--APRYPSPPMGSVSAPNLPTAEDNL 125 +++F L L+E+YK H L TTL P P + + G+ A N + L Sbjct: 172 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGN-RAGNSLLSPKVL 230 Query: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180 YDF D +L KG+++ I K W +GRVG P YVE+ Sbjct: 231 GIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEE 285 Score = 52.4 bits (124), Expect = 5e-07 Identities = 28/56 (50%), Positives = 36/56 (64%), Gaps = 1/56 (1%) Query: 238 VFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFTHVK 292 V AI + CA D L+L GD+VK+ T+M+ NG W GEVNGR G FP T+V+ Sbjct: 229 VLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 284 >gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 [Homo sapiens] Length = 847 Score = 68.9 bits (167), Expect = 5e-12 Identities = 51/175 (29%), Positives = 78/175 (44%), Gaps = 9/175 (5%) Query: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73 WY G + R +A+T L + + +LVR + G+Y +S+ N+ H I + Sbjct: 672 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 731 Query: 74 GDQEFDHLPALLEFYKIHYLDT------TTLIEP--APRYPSPPMGSVSAPNLPTAEDNL 125 +++F L L+E+YK H L TTL P P + + G+ A N + L Sbjct: 732 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGN-RAGNSLLSPKVL 790 Query: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180 YDF D +L KG+++ I K W +GRVG P YVE+ Sbjct: 791 GIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEE 845 Score = 52.4 bits (124), Expect = 5e-07 Identities = 28/56 (50%), Positives = 36/56 (64%), Gaps = 1/56 (1%) Query: 238 VFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFTHVK 292 V AI + CA D L+L GD+VK+ T+M+ NG W GEVNGR G FP T+V+ Sbjct: 789 VLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 844 >gi|11321634 CD2-associated protein [Homo sapiens] Length = 639 Score = 64.7 bits (156), Expect = 1e-10 Identities = 44/164 (26%), Positives = 72/164 (43%), Gaps = 11/164 (6%) Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191 YD+ ++L + GEI+ ++K +E+ W +GR GM P +V+++ R + Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRET------ 61 Query: 192 NRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAY 251 +P + + + G P I P P T+N K Q +V Y Sbjct: 62 --EFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEY 119 Query: 252 ---DKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVK 292 ++ L L+VGDI+ + G W G +N + GLFP VK Sbjct: 120 IPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVK 163 Score = 40.8 bits (94), Expect = 0.001 Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 3/51 (5%) Query: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKP--EEQWWSARNKDGRVGMIP 174 EY RTL+ + G + ++L FK+GEI+ +I K E WW +G+ G+ P Sbjct: 272 EYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRG-ELNGKEGVFP 321 Score = 39.3 bits (90), Expect = 0.004 Identities = 48/219 (21%), Positives = 87/219 (39%), Gaps = 71/219 (32%) Query: 129 RTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHG 188 + L+++ + ++L K G+I+ I E+ EE WWS + ++G+ P +V++L + Sbjct: 114 KVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSG-TLNNKLGLFPSNFVKELEVTDDGE 172 Query: 189 KHGNRNSNSYGIPEPAHAYAQPQTTTPLPA---VSGSPGAAIT----------------- 228 H ++ + + P T+P+P+ VS + ++T Sbjct: 173 THEAQDDSETVLAGP---------TSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEG 223 Query: 229 --------------------PL------PSTQN---------GPVFAKAIQKRVPCAYDK 253 PL P TQ+ G + AK R AY+ Sbjct: 224 SVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKE-YCRTLFAYEG 282 Query: 254 T---ALALEVGDIVKVTRMNIN--GQWEGEVNGRKGLFP 287 T L + G+I+ + G W GE+NG++G+FP Sbjct: 283 TNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFP 321 >gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [Homo sapiens] Length = 839 Score = 63.2 bits (152), Expect = 3e-10 Identities = 44/176 (25%), Positives = 74/176 (42%), Gaps = 12/176 (6%) Query: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73 W+ G + RQ+ L+ G +L+R+ + +S+ N V H + N Sbjct: 663 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHIT 722 Query: 74 GDQEFDHLPALLEFYKIH-------YLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLE 126 ++FD L L+E+Y+ H LDTT R S S +P Sbjct: 723 EAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTA 782 Query: 127 YVRTLYDFPGNDAEDLPFKKGEILVIIEK--PEEQWWSARNKDGRVGMIPVPYVEK 180 R Y+F D +L ++G+++ I + ++ WW +GR+G P YVE+ Sbjct: 783 VAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGET-NGRIGWFPSTYVEE 835 Score = 38.9 bits (89), Expect = 0.006 Identities = 29/90 (32%), Positives = 41/90 (45%), Gaps = 3/90 (3%) Query: 206 AYAQPQTTTPLPAVSGSPGAAITPLPSTQNGP-VFAKAIQKRVPCAYDKTALALEVGDIV 264 ++ Q TT P S A+ S P V A+ + A D L+L GD+V Sbjct: 745 SFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTAVARYNFAARDMRELSLREGDVV 804 Query: 265 KVTRM--NINGQWEGEVNGRKGLFPFTHVK 292 ++ G W+GE NGR G FP T+V+ Sbjct: 805 RIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834 >gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a [Homo sapiens] Length = 1130 Score = 60.1 bits (144), Expect = 2e-09 Identities = 41/118 (34%), Positives = 61/118 (51%), Gaps = 13/118 (11%) Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66 +S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+ Sbjct: 120 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 179 Query: 67 PNRRFKI-GDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVSAPN 117 + + + + F+ L L +H+ T TTL PAP+ P + VS PN Sbjct: 180 SDGKLYVSSESRFNTLAEL-----VHHHSTVADGLITTLHYPAPKRNKPTVYGVS-PN 231 Score = 29.3 bits (64), Expect = 4.5 Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 5/72 (6%) Query: 131 LYDFPGNDAEDLPFKKGEIL-VIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHG- 188 LYDF + L KGE L V+ +W A+ K+G+ G +P Y+ + H Sbjct: 69 LYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEKHSW 127 Query: 189 KHG--NRNSNSY 198 HG +RN+ Y Sbjct: 128 YHGPVSRNAAEY 139 >gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b [Homo sapiens] Length = 1149 Score = 60.1 bits (144), Expect = 2e-09 Identities = 41/118 (34%), Positives = 61/118 (51%), Gaps = 13/118 (11%) Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66 +S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+ Sbjct: 139 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 198 Query: 67 PNRRFKI-GDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVSAPN 117 + + + + F+ L L +H+ T TTL PAP+ P + VS PN Sbjct: 199 SDGKLYVSSESRFNTLAEL-----VHHHSTVADGLITTLHYPAPKRNKPTVYGVS-PN 250 Score = 29.3 bits (64), Expect = 4.5 Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 5/72 (6%) Query: 131 LYDFPGNDAEDLPFKKGEIL-VIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHG- 188 LYDF + L KGE L V+ +W A+ K+G+ G +P Y+ + H Sbjct: 88 LYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEKHSW 146 Query: 189 KHG--NRNSNSY 198 HG +RN+ Y Sbjct: 147 YHGPVSRNAAEY 158 >gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo sapiens] Length = 756 Score = 60.1 bits (144), Expect = 2e-09 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 20/159 (12%) Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191 + + A++L + GEI+ +I++ E+ WW + K+G++G P +VE L P Sbjct: 92 FSYSPEQADELKLQAGEIVEMIKEIEDGWWLGK-KNGQLGAFPSNFVELLDSGPP----- 145 Query: 192 NRNSNSYGIPEPAHAYAQPQTTTPLPAVS-GSPGAAITPLPSTQNGPVFAKAIQKRVPCA 250 S G P+ PQ L +++ SP + T + P + + P A Sbjct: 146 -----SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYL----QTVSHPEVYRVLFDYQPEA 196 Query: 251 YDKTALALEVGDIVKVTRMNIN--GQWEGEVNGRKGLFP 287 D+ LAL GD+VKV G WEGE GR+G+FP Sbjct: 197 PDE--LALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFP 233 Score = 37.4 bits (85), Expect = 0.017 Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 13/95 (13%) Query: 99 IEPAPRYPSPPMGSV---SAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEK 155 + P P+ P P + S+ S P+ + E R L+D+ ++L ++G+++ ++ K Sbjct: 155 VSPGPQRP-PKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSK 213 Query: 156 PEEQ--WWSARNKDGRVG------MIPVPYVEKLV 182 E WW + GR G ++P P ++KLV Sbjct: 214 TTEDKGWWEGECQ-GRRGVFPDNFVLPPPPIKKLV 247 Score = 35.0 bits (79), Expect = 0.082 Identities = 16/44 (36%), Positives = 26/44 (59%) Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNP 299 L L+ G+IV++ + +G W G+ NG+ G FP V++ D P Sbjct: 102 LKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145 >gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] Length = 1167 Score = 59.3 bits (142), Expect = 4e-09 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%) Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66 +S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+ Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210 Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114 + + + + F L L +H+ T TTL PAP+ P + VS Sbjct: 211 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 260 >gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] Length = 1182 Score = 59.3 bits (142), Expect = 4e-09 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%) Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66 +S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+ Sbjct: 166 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225 Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114 + + + + F L L +H+ T TTL PAP+ P + VS Sbjct: 226 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 275 >gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] Length = 542 Score = 59.3 bits (142), Expect = 4e-09 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%) Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66 +S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+ Sbjct: 145 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204 Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114 + + + + F L L +H+ T TTL PAP+ P + VS Sbjct: 205 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 254 >gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] Length = 1064 Score = 59.3 bits (142), Expect = 4e-09 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%) Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66 +S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+ Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210 Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114 + + + + F L L +H+ T TTL PAP+ P + VS Sbjct: 211 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 260 >gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] Length = 1146 Score = 59.3 bits (142), Expect = 4e-09 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%) Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66 +S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+ Sbjct: 130 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189 Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114 + + + + F L L +H+ T TTL PAP+ P + VS Sbjct: 190 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 239 >gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] Length = 1291 Score = 58.5 bits (140), Expect = 7e-09 Identities = 54/215 (25%), Positives = 88/215 (40%), Gaps = 35/215 (16%) Query: 7 DSSDRSAWYMGPVSRQEAQTRLQG-QRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINS 65 ++ + WY ++R +A+ L R G FLVR + P Y +S ++ H + Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNE-PNSYAISFRAEGKIKHCRVQQ 719 Query: 66 LPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYP------------SPPMGS- 112 + +G+ EFD L L+ +Y+ H L + RYP P G+ Sbjct: 720 -EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKL----RYPINEEALEKIGTAEPDYGAL 774 Query: 113 ---------VSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSA 163 V A +PT + V+ L+D+ ++L F K I+ +EK E WW Sbjct: 775 YEGRNPGFYVEANPMPTFKCA---VKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRG 831 Query: 164 RNKDGRVGMIPVPYVEKLVRS---SPHGKHGNRNS 195 + P YVE++V P +H + NS Sbjct: 832 DYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENS 866 Score = 36.6 bits (83), Expect = 0.028 Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 4/64 (6%) Query: 30 GQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPN----RRFKIGDQEFDHLPALL 85 G G FLVR+S T GDY LS N +V H I+S + + F + FD L L+ Sbjct: 577 GAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLI 636 Query: 86 EFYK 89 Y+ Sbjct: 637 THYQ 640 >gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] Length = 1290 Score = 58.5 bits (140), Expect = 7e-09 Identities = 54/215 (25%), Positives = 88/215 (40%), Gaps = 35/215 (16%) Query: 7 DSSDRSAWYMGPVSRQEAQTRLQG-QRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINS 65 ++ + WY ++R +A+ L R G FLVR + P Y +S ++ H + Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNE-PNSYAISFRAEGKIKHCRVQQ 719 Query: 66 LPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYP------------SPPMGS- 112 + +G+ EFD L L+ +Y+ H L + RYP P G+ Sbjct: 720 -EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKL----RYPINEEALEKIGTAEPDYGAL 774 Query: 113 ---------VSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSA 163 V A +PT + V+ L+D+ ++L F K I+ +EK E WW Sbjct: 775 YEGRNPGFYVEANPMPTFKCA---VKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRG 831 Query: 164 RNKDGRVGMIPVPYVEKLVRS---SPHGKHGNRNS 195 + P YVE++V P +H + NS Sbjct: 832 DYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENS 866 Score = 36.6 bits (83), Expect = 0.028 Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 4/64 (6%) Query: 30 GQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPN----RRFKIGDQEFDHLPALL 85 G G FLVR+S T GDY LS N +V H I+S + + F + FD L L+ Sbjct: 577 GAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLI 636 Query: 86 EFYK 89 Y+ Sbjct: 637 THYQ 640 >gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo sapiens] Length = 492 Score = 58.2 bits (139), Expect = 9e-09 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%) Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154 ++TL + P G+ LP + +YDF +++L FKKG+ + I+ Sbjct: 235 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 286 Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214 K ++ W+ + GRVG+ P+ YVEKL PE A A+P Sbjct: 287 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 323 Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274 P PA G G +AI K A L+L GD V + + Sbjct: 324 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 367 Query: 275 WEGEVNG--RKGLFPFTHVKI 293 +EG++ G R+G+FP ++V++ Sbjct: 368 YEGKIPGTNRQGIFPVSYVEV 388 Score = 32.3 bits (72), Expect = 0.53 Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296 L+ + GD V + R +EGE +GR G+FP ++V+ P Sbjct: 274 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314 Score = 30.0 bits (66), Expect = 2.6 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%) Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145 A YP PP+ S + P P +N+ E + LY++ + ++L + Sbjct: 396 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 455 Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181 + +++ ++EK ++ W+ ++ + G P YV++L Sbjct: 456 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492 >gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo sapiens] Length = 1004 Score = 58.2 bits (139), Expect = 9e-09 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%) Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154 ++TL + P G+ LP + +YDF +++L FKKG+ + I+ Sbjct: 747 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 798 Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214 K ++ W+ + GRVG+ P+ YVEKL PE A A+P Sbjct: 799 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 835 Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274 P PA G G +AI K A L+L GD V + + Sbjct: 836 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 879 Query: 275 WEGEVNG--RKGLFPFTHVKI 293 +EG++ G R+G+FP ++V++ Sbjct: 880 YEGKIPGTNRQGIFPVSYVEV 900 Score = 32.3 bits (72), Expect = 0.53 Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296 L+ + GD V + R +EGE +GR G+FP ++V+ P Sbjct: 786 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826 Score = 30.0 bits (66), Expect = 2.6 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%) Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145 A YP PP+ S + P P +N+ E + LY++ + ++L + Sbjct: 908 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 967 Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181 + +++ ++EK ++ W+ ++ + G P YV++L Sbjct: 968 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004 >gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo sapiens] Length = 824 Score = 58.2 bits (139), Expect = 9e-09 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%) Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154 ++TL + P G+ LP + +YDF +++L FKKG+ + I+ Sbjct: 567 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 618 Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214 K ++ W+ + GRVG+ P+ YVEKL PE A A+P Sbjct: 619 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 655 Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274 P PA G G +AI K A L+L GD V + + Sbjct: 656 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 699 Query: 275 WEGEVNG--RKGLFPFTHVKI 293 +EG++ G R+G+FP ++V++ Sbjct: 700 YEGKIPGTNRQGIFPVSYVEV 720 Score = 32.3 bits (72), Expect = 0.53 Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296 L+ + GD V + R +EGE +GR G+FP ++V+ P Sbjct: 606 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646 Score = 30.0 bits (66), Expect = 2.6 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%) Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145 A YP PP+ S + P P +N+ E + LY++ + ++L + Sbjct: 728 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 787 Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181 + +++ ++EK ++ W+ ++ + G P YV++L Sbjct: 788 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824 >gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo sapiens] Length = 661 Score = 58.2 bits (139), Expect = 9e-09 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%) Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154 ++TL + P G+ LP + +YDF +++L FKKG+ + I+ Sbjct: 404 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 455 Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214 K ++ W+ + GRVG+ P+ YVEKL PE A A+P Sbjct: 456 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 492 Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274 P PA G G +AI K A L+L GD V + + Sbjct: 493 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 536 Query: 275 WEGEVNG--RKGLFPFTHVKI 293 +EG++ G R+G+FP ++V++ Sbjct: 537 YEGKIPGTNRQGIFPVSYVEV 557 Score = 32.3 bits (72), Expect = 0.53 Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296 L+ + GD V + R +EGE +GR G+FP ++V+ P Sbjct: 443 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483 Score = 30.0 bits (66), Expect = 2.6 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%) Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145 A YP PP+ S + P P +N+ E + LY++ + ++L + Sbjct: 565 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 624 Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181 + +++ ++EK ++ W+ ++ + G P YV++L Sbjct: 625 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661 >gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo sapiens] Length = 731 Score = 58.2 bits (139), Expect = 9e-09 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%) Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154 ++TL + P G+ LP + +YDF +++L FKKG+ + I+ Sbjct: 474 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 525 Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214 K ++ W+ + GRVG+ P+ YVEKL PE A A+P Sbjct: 526 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 562 Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274 P PA G G +AI K A L+L GD V + + Sbjct: 563 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 606 Query: 275 WEGEVNG--RKGLFPFTHVKI 293 +EG++ G R+G+FP ++V++ Sbjct: 607 YEGKIPGTNRQGIFPVSYVEV 627 Score = 32.3 bits (72), Expect = 0.53 Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296 L+ + GD V + R +EGE +GR G+FP ++V+ P Sbjct: 513 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553 Score = 30.0 bits (66), Expect = 2.6 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%) Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145 A YP PP+ S + P P +N+ E + LY++ + ++L + Sbjct: 635 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 694 Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181 + +++ ++EK ++ W+ ++ + G P YV++L Sbjct: 695 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731 >gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo sapiens] Length = 644 Score = 58.2 bits (139), Expect = 9e-09 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%) Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154 ++TL + P G+ LP + +YDF +++L FKKG+ + I+ Sbjct: 387 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 438 Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214 K ++ W+ + GRVG+ P+ YVEKL PE A A+P Sbjct: 439 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 475 Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274 P PA G G +AI K A L+L GD V + + Sbjct: 476 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 519 Query: 275 WEGEVNG--RKGLFPFTHVKI 293 +EG++ G R+G+FP ++V++ Sbjct: 520 YEGKIPGTNRQGIFPVSYVEV 540 Score = 32.3 bits (72), Expect = 0.53 Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296 L+ + GD V + R +EGE +GR G+FP ++V+ P Sbjct: 426 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466 Score = 30.0 bits (66), Expect = 2.6 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%) Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145 A YP PP+ S + P P +N+ E + LY++ + ++L + Sbjct: 548 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 607 Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181 + +++ ++EK ++ W+ ++ + G P YV++L Sbjct: 608 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644 >gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo sapiens] Length = 1100 Score = 58.2 bits (139), Expect = 9e-09 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%) Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154 ++TL + P G+ LP + +YDF +++L FKKG+ + I+ Sbjct: 843 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 894 Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214 K ++ W+ + GRVG+ P+ YVEKL PE A A+P Sbjct: 895 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 931 Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274 P PA G G +AI K A L+L GD V + + Sbjct: 932 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 975 Query: 275 WEGEVNG--RKGLFPFTHVKI 293 +EG++ G R+G+FP ++V++ Sbjct: 976 YEGKIPGTNRQGIFPVSYVEV 996 Score = 32.3 bits (72), Expect = 0.53 Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296 L+ + GD V + R +EGE +GR G+FP ++V+ P Sbjct: 882 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922 Score = 30.0 bits (66), Expect = 2.6 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%) Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145 A YP PP+ S + P P +N+ E + LY++ + ++L + Sbjct: 1004 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 1063 Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181 + +++ ++EK ++ W+ ++ + G P YV++L Sbjct: 1064 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100 >gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo sapiens] Length = 666 Score = 58.2 bits (139), Expect = 9e-09 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%) Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154 ++TL + P G+ LP + +YDF +++L FKKG+ + I+ Sbjct: 409 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 460 Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214 K ++ W+ + GRVG+ P+ YVEKL PE A A+P Sbjct: 461 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 497 Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274 P PA G G +AI K A L+L GD V + + Sbjct: 498 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 541 Query: 275 WEGEVNG--RKGLFPFTHVKI 293 +EG++ G R+G+FP ++V++ Sbjct: 542 YEGKIPGTNRQGIFPVSYVEV 562 Score = 32.3 bits (72), Expect = 0.53 Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296 L+ + GD V + R +EGE +GR G+FP ++V+ P Sbjct: 448 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 488 Score = 30.0 bits (66), Expect = 2.6 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%) Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145 A YP PP+ S + P P +N+ E + LY++ + ++L + Sbjct: 570 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 629 Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181 + +++ ++EK ++ W+ ++ + G P YV++L Sbjct: 630 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666 >gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] Length = 380 Score = 57.8 bits (138), Expect = 1e-08 Identities = 38/99 (38%), Positives = 51/99 (51%), Gaps = 19/99 (19%) Query: 125 LEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEE--QWWSARNKDGRVGMIPVPYVEKLV 182 L V+TLY F E+L F+KGE + +IEKPE +WW +N G+VG++P YV +V Sbjct: 197 LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV--VV 254 Query: 183 RSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSG 221 S H PAHA PQ + P+ SG Sbjct: 255 LSDGPALH------------PAHA---PQISYTGPSSSG 278 Score = 50.4 bits (119), Expect = 2e-06 Identities = 47/166 (28%), Positives = 67/166 (40%), Gaps = 17/166 (10%) Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191 +D+ ++L KK E L +++ + WW RN R G +P YVE+ S G Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDD-SKTWWRVRNAANRTGYVPSNYVER-KNSLKKGSLV 68 Query: 192 NRNSNSYGIPEPAH------AYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQK 245 ++ G+ + A P T PA +GS I L N P F K Sbjct: 69 KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPA-NGSGADRIYDL----NIPAFVKFAY- 122 Query: 246 RVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHV 291 A + L+L G V V +G W G NG+ G FP +V Sbjct: 123 ---VAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYV 165 Score = 48.9 bits (115), Expect = 5e-06 Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 5/89 (5%) Query: 2 SSARFDSSDRSAWYMGPVSRQEAQTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSH 60 SS RF + WY G V+R +A+ L + G FL+RDS + P D+ +S+ + + H Sbjct: 276 SSGRFAGRE---WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKH 332 Query: 61 YIINSLPNRRFKIGDQEFDHLPALLEFYK 89 + + + N + IG + F + L+E YK Sbjct: 333 FKVQLVDN-VYCIGQRRFHTMDELVEHYK 360 >gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] Length = 380 Score = 57.8 bits (138), Expect = 1e-08 Identities = 38/99 (38%), Positives = 51/99 (51%), Gaps = 19/99 (19%) Query: 125 LEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEE--QWWSARNKDGRVGMIPVPYVEKLV 182 L V+TLY F E+L F+KGE + +IEKPE +WW +N G+VG++P YV +V Sbjct: 197 LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV--VV 254 Query: 183 RSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSG 221 S H PAHA PQ + P+ SG Sbjct: 255 LSDGPALH------------PAHA---PQISYTGPSSSG 278 Score = 50.4 bits (119), Expect = 2e-06 Identities = 47/166 (28%), Positives = 67/166 (40%), Gaps = 17/166 (10%) Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191 +D+ ++L KK E L +++ + WW RN R G +P YVE+ S G Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDD-SKTWWRVRNAANRTGYVPSNYVER-KNSLKKGSLV 68 Query: 192 NRNSNSYGIPEPAH------AYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQK 245 ++ G+ + A P T PA +GS I L N P F K Sbjct: 69 KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPA-NGSGADRIYDL----NIPAFVKFAY- 122 Query: 246 RVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHV 291 A + L+L G V V +G W G NG+ G FP +V Sbjct: 123 ---VAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYV 165 Score = 48.9 bits (115), Expect = 5e-06 Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 5/89 (5%) Query: 2 SSARFDSSDRSAWYMGPVSRQEAQTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSH 60 SS RF + WY G V+R +A+ L + G FL+RDS + P D+ +S+ + + H Sbjct: 276 SSGRFAGRE---WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKH 332 Query: 61 YIINSLPNRRFKIGDQEFDHLPALLEFYK 89 + + + N + IG + F + L+E YK Sbjct: 333 FKVQLVDN-VYCIGQRRFHTMDELVEHYK 360 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.134 0.409 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,489,964 Number of Sequences: 37866 Number of extensions: 724049 Number of successful extensions: 3634 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 287 Number of HSP's successfully gapped in prelim test: 96 Number of HSP's that attempted gapping in prelim test: 2831 Number of HSP's gapped (non-prelim): 739 length of query: 303 length of database: 18,247,518 effective HSP length: 102 effective length of query: 201 effective length of database: 14,385,186 effective search space: 2891422386 effective search space used: 2891422386 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.