Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4885153
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885153 v-crk sarcoma virus CT10 oncogene homolog
(avian)-like [Homo sapiens]
(303 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 628 e-180
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 345 2e-95
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 231 6e-61
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 89 4e-18
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 72 5e-13
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 72 6e-13
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 69 5e-12
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 69 5e-12
gi|11321634 CD2-associated protein [Homo sapiens] 65 1e-10
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 63 3e-10
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 60 2e-09
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 60 2e-09
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 60 2e-09
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 59 4e-09
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 59 4e-09
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 59 4e-09
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 59 4e-09
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 59 4e-09
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 59 7e-09
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 59 7e-09
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 58 9e-09
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 58 9e-09
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 58 9e-09
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 58 9e-09
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 58 9e-09
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 58 9e-09
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 58 9e-09
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 58 9e-09
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 58 1e-08
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 58 1e-08
>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
[Homo sapiens]
Length = 303
Score = 628 bits (1620), Expect = e-180
Identities = 303/303 (100%), Positives = 303/303 (100%)
Query: 1 MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH 60
MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH
Sbjct: 1 MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH 60
Query: 61 YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT 120
YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT
Sbjct: 61 YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT 120
Query: 121 AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK
Sbjct: 121 AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
Query: 181 LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA 240
LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA
Sbjct: 181 LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA 240
Query: 241 KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD 300
KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD
Sbjct: 241 KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD 300
Query: 301 ENE 303
ENE
Sbjct: 301 ENE 303
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 345 bits (886), Expect = 2e-95
Identities = 184/323 (56%), Positives = 217/323 (67%), Gaps = 45/323 (13%)
Query: 3 SARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYI 62
+ FDS +RS+WY G +SRQEA LQGQRHG+FLVRDSST PGDYVLSVSENSRVSHYI
Sbjct: 2 AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYI 61
Query: 63 INSLPNR-----------------RFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY 105
INS R R +IGDQEFD LPALLEFYKIHYLDTTTLIEP R
Sbjct: 62 INSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR- 120
Query: 106 PSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN 165
S + ++ EYVR L+DF GND EDLPFKKG+IL I +KPEEQWW+A +
Sbjct: 121 ------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174
Query: 166 KDGRVGMIPVPYVEKLVRSSPH------GKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAV 219
+G+ GMIPVPYVEK +S G + G PEP YAQP TPLP
Sbjct: 175 SEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPG-PYAQPSVNTPLP-- 231
Query: 220 SGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEV 279
+ QNGP++A+ IQKRVP AYDKTALALEVG++VKVT++N++GQWEGE
Sbjct: 232 ------------NLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGEC 279
Query: 280 NGRKGLFPFTHVKIFDPQNPDEN 302
NG++G FPFTHV++ D QNPDE+
Sbjct: 280 NGKRGHFPFTHVRLLDQQNPDED 302
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 231 bits (589), Expect = 6e-61
Identities = 121/195 (62%), Positives = 137/195 (70%), Gaps = 24/195 (12%)
Query: 3 SARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYI 62
+ FDS +RS+WY G +SRQEA LQGQRHG+FLVRDSST PGDYVLSVSENSRVSHYI
Sbjct: 2 AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYI 61
Query: 63 INSLPNR-----------------RFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY 105
INS R R +IGDQEFD LPALLEFYKIHYLDTTTLIEP R
Sbjct: 62 INSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR- 120
Query: 106 PSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN 165
S + ++ EYVR L+DF GND EDLPFKKG+IL I +KPEEQWW+A +
Sbjct: 121 ------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174
Query: 166 KDGRVGMIPVPYVEK 180
+G+ GMIPVPYVEK
Sbjct: 175 SEGKRGMIPVPYVEK 189
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 89.4 bits (220), Expect = 4e-18
Identities = 48/167 (28%), Positives = 90/167 (53%), Gaps = 14/167 (8%)
Query: 14 WYMGPVSRQEAQTRLQGQRH-GMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFK 72
WY G +SRQ A+ L + H G FL+R+S + PG++ +SV+ +V H+ + + ++
Sbjct: 60 WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYF 119
Query: 73 IGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLY 132
+ +++F+ L L++FY+ TTT+ + + + +P + + +
Sbjct: 120 LWEEKFNSLNELVDFYR-----TTTIAKKRQIFLRDEEPLLKSPGAC-------FAQAQF 167
Query: 133 DFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVE 179
DF D L F++G+I+ ++E+P+ WW R+ GRVG P YV+
Sbjct: 168 DFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRS-CGRVGFFPRSYVQ 213
Score = 38.5 bits (88), Expect = 0.007
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 4/65 (6%)
Query: 131 LYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKH 190
LY F ++++L F KG+ L I+ ++Q W G G IP Y +R PH +
Sbjct: 6 LYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNY----IRVKPHPWY 61
Query: 191 GNRNS 195
R S
Sbjct: 62 SGRIS 66
Score = 30.0 bits (66), Expect = 2.6
Identities = 15/43 (34%), Positives = 22/43 (51%)
Query: 250 AYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVK 292
A D + L+ GDI++V W G GR G FP ++V+
Sbjct: 171 AQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQ 213
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 72.4 bits (176), Expect = 5e-13
Identities = 49/170 (28%), Positives = 79/170 (46%), Gaps = 4/170 (2%)
Query: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
WY GP+ R A++ L + G FLVR ++ +S+ N V H I +
Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRIT 730
Query: 74 GDQEFDHLPALLEFYKIHYL-DTTTLIEPAPRYP--SPPMGSVSAPNLPTAEDNLEYVRT 130
+ F L L+EFY+ + L D ++ ++P P ++S P + + + +
Sbjct: 731 EKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTK-YFGTAKA 789
Query: 131 LYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
YDF D +L K+G+I+ I+ K +Q W GRVG P YVE+
Sbjct: 790 RYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEE 839
Score = 42.7 bits (99), Expect = 4e-04
Identities = 22/63 (34%), Positives = 35/63 (55%), Gaps = 1/63 (1%)
Query: 231 PSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFT 289
P+ + F A + CA D++ L+L+ GDI+K+ + G W GE+ GR G FP
Sbjct: 776 PAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPAN 835
Query: 290 HVK 292
+V+
Sbjct: 836 YVE 838
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 72.0 bits (175), Expect = 6e-13
Identities = 45/177 (25%), Positives = 84/177 (47%), Gaps = 26/177 (14%)
Query: 14 WYMGPVSRQEAQTRLQGQRH-GMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFK 72
W+ G + R +A+ L QRH G FL+R+S + PGD+ LSV + V H+ + ++
Sbjct: 60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119
Query: 73 IGDQEFDHLPALLEFYKIHYLDTTTLI-----EPAPRYPSPPMGSVSAPNLPTAEDNLEY 127
+ +F+ L L+++++ + I E P+ P+ Y
Sbjct: 120 LWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPT-------------------Y 160
Query: 128 VRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRS 184
V+ L+DF + +L F++G+ + +++ + WW G+ GM P YV + R+
Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA-CHGQTGMFPRNYVTPVNRN 216
Score = 39.7 bits (91), Expect = 0.003
Identities = 17/48 (35%), Positives = 28/48 (58%)
Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVE 179
YDF ++L FK+G+IL ++ + +Q W +G+ G IP Y+E
Sbjct: 7 YDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 68.9 bits (167), Expect = 5e-12
Identities = 51/175 (29%), Positives = 78/175 (44%), Gaps = 9/175 (5%)
Query: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
WY G + R +A+T L + + +LVR + G+Y +S+ N+ H I +
Sbjct: 112 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 171
Query: 74 GDQEFDHLPALLEFYKIHYLDT------TTLIEP--APRYPSPPMGSVSAPNLPTAEDNL 125
+++F L L+E+YK H L TTL P P + + G+ A N + L
Sbjct: 172 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGN-RAGNSLLSPKVL 230
Query: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
YDF D +L KG+++ I K W +GRVG P YVE+
Sbjct: 231 GIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEE 285
Score = 52.4 bits (124), Expect = 5e-07
Identities = 28/56 (50%), Positives = 36/56 (64%), Gaps = 1/56 (1%)
Query: 238 VFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFTHVK 292
V AI + CA D L+L GD+VK+ T+M+ NG W GEVNGR G FP T+V+
Sbjct: 229 VLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 284
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 68.9 bits (167), Expect = 5e-12
Identities = 51/175 (29%), Positives = 78/175 (44%), Gaps = 9/175 (5%)
Query: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
WY G + R +A+T L + + +LVR + G+Y +S+ N+ H I +
Sbjct: 672 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 731
Query: 74 GDQEFDHLPALLEFYKIHYLDT------TTLIEP--APRYPSPPMGSVSAPNLPTAEDNL 125
+++F L L+E+YK H L TTL P P + + G+ A N + L
Sbjct: 732 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGN-RAGNSLLSPKVL 790
Query: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
YDF D +L KG+++ I K W +GRVG P YVE+
Sbjct: 791 GIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEE 845
Score = 52.4 bits (124), Expect = 5e-07
Identities = 28/56 (50%), Positives = 36/56 (64%), Gaps = 1/56 (1%)
Query: 238 VFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFTHVK 292
V AI + CA D L+L GD+VK+ T+M+ NG W GEVNGR G FP T+V+
Sbjct: 789 VLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 844
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 64.7 bits (156), Expect = 1e-10
Identities = 44/164 (26%), Positives = 72/164 (43%), Gaps = 11/164 (6%)
Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191
YD+ ++L + GEI+ ++K +E+ W +GR GM P +V+++ R +
Sbjct: 8 YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRET------ 61
Query: 192 NRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAY 251
+P + + + G P I P P T+N K Q +V Y
Sbjct: 62 --EFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEY 119
Query: 252 ---DKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVK 292
++ L L+VGDI+ + G W G +N + GLFP VK
Sbjct: 120 IPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVK 163
Score = 40.8 bits (94), Expect = 0.001
Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKP--EEQWWSARNKDGRVGMIP 174
EY RTL+ + G + ++L FK+GEI+ +I K E WW +G+ G+ P
Sbjct: 272 EYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRG-ELNGKEGVFP 321
Score = 39.3 bits (90), Expect = 0.004
Identities = 48/219 (21%), Positives = 87/219 (39%), Gaps = 71/219 (32%)
Query: 129 RTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHG 188
+ L+++ + ++L K G+I+ I E+ EE WWS + ++G+ P +V++L +
Sbjct: 114 KVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSG-TLNNKLGLFPSNFVKELEVTDDGE 172
Query: 189 KHGNRNSNSYGIPEPAHAYAQPQTTTPLPA---VSGSPGAAIT----------------- 228
H ++ + + P T+P+P+ VS + ++T
Sbjct: 173 THEAQDDSETVLAGP---------TSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEG 223
Query: 229 --------------------PL------PSTQN---------GPVFAKAIQKRVPCAYDK 253
PL P TQ+ G + AK R AY+
Sbjct: 224 SVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKE-YCRTLFAYEG 282
Query: 254 T---ALALEVGDIVKVTRMNIN--GQWEGEVNGRKGLFP 287
T L + G+I+ + G W GE+NG++G+FP
Sbjct: 283 TNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFP 321
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 63.2 bits (152), Expect = 3e-10
Identities = 44/176 (25%), Positives = 74/176 (42%), Gaps = 12/176 (6%)
Query: 14 WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
W+ G + RQ+ L+ G +L+R+ + +S+ N V H + N
Sbjct: 663 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHIT 722
Query: 74 GDQEFDHLPALLEFYKIH-------YLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLE 126
++FD L L+E+Y+ H LDTT R S S +P
Sbjct: 723 EAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTA 782
Query: 127 YVRTLYDFPGNDAEDLPFKKGEILVIIEK--PEEQWWSARNKDGRVGMIPVPYVEK 180
R Y+F D +L ++G+++ I + ++ WW +GR+G P YVE+
Sbjct: 783 VAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGET-NGRIGWFPSTYVEE 835
Score = 38.9 bits (89), Expect = 0.006
Identities = 29/90 (32%), Positives = 41/90 (45%), Gaps = 3/90 (3%)
Query: 206 AYAQPQTTTPLPAVSGSPGAAITPLPSTQNGP-VFAKAIQKRVPCAYDKTALALEVGDIV 264
++ Q TT P S A+ S P V A+ + A D L+L GD+V
Sbjct: 745 SFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTAVARYNFAARDMRELSLREGDVV 804
Query: 265 KVTRM--NINGQWEGEVNGRKGLFPFTHVK 292
++ G W+GE NGR G FP T+V+
Sbjct: 805 RIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 60.1 bits (144), Expect = 2e-09
Identities = 41/118 (34%), Positives = 61/118 (51%), Gaps = 13/118 (11%)
Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
+S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+
Sbjct: 120 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 179
Query: 67 PNRRFKI-GDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVSAPN 117
+ + + + F+ L L +H+ T TTL PAP+ P + VS PN
Sbjct: 180 SDGKLYVSSESRFNTLAEL-----VHHHSTVADGLITTLHYPAPKRNKPTVYGVS-PN 231
Score = 29.3 bits (64), Expect = 4.5
Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 5/72 (6%)
Query: 131 LYDFPGNDAEDLPFKKGEIL-VIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHG- 188
LYDF + L KGE L V+ +W A+ K+G+ G +P Y+ + H
Sbjct: 69 LYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEKHSW 127
Query: 189 KHG--NRNSNSY 198
HG +RN+ Y
Sbjct: 128 YHGPVSRNAAEY 139
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 60.1 bits (144), Expect = 2e-09
Identities = 41/118 (34%), Positives = 61/118 (51%), Gaps = 13/118 (11%)
Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
+S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+
Sbjct: 139 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 198
Query: 67 PNRRFKI-GDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVSAPN 117
+ + + + F+ L L +H+ T TTL PAP+ P + VS PN
Sbjct: 199 SDGKLYVSSESRFNTLAEL-----VHHHSTVADGLITTLHYPAPKRNKPTVYGVS-PN 250
Score = 29.3 bits (64), Expect = 4.5
Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 5/72 (6%)
Query: 131 LYDFPGNDAEDLPFKKGEIL-VIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHG- 188
LYDF + L KGE L V+ +W A+ K+G+ G +P Y+ + H
Sbjct: 88 LYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEKHSW 146
Query: 189 KHG--NRNSNSY 198
HG +RN+ Y
Sbjct: 147 YHGPVSRNAAEY 158
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 60.1 bits (144), Expect = 2e-09
Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 20/159 (12%)
Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191
+ + A++L + GEI+ +I++ E+ WW + K+G++G P +VE L P
Sbjct: 92 FSYSPEQADELKLQAGEIVEMIKEIEDGWWLGK-KNGQLGAFPSNFVELLDSGPP----- 145
Query: 192 NRNSNSYGIPEPAHAYAQPQTTTPLPAVS-GSPGAAITPLPSTQNGPVFAKAIQKRVPCA 250
S G P+ PQ L +++ SP + T + P + + P A
Sbjct: 146 -----SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYL----QTVSHPEVYRVLFDYQPEA 196
Query: 251 YDKTALALEVGDIVKVTRMNIN--GQWEGEVNGRKGLFP 287
D+ LAL GD+VKV G WEGE GR+G+FP
Sbjct: 197 PDE--LALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFP 233
Score = 37.4 bits (85), Expect = 0.017
Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 13/95 (13%)
Query: 99 IEPAPRYPSPPMGSV---SAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEK 155
+ P P+ P P + S+ S P+ + E R L+D+ ++L ++G+++ ++ K
Sbjct: 155 VSPGPQRP-PKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSK 213
Query: 156 PEEQ--WWSARNKDGRVG------MIPVPYVEKLV 182
E WW + GR G ++P P ++KLV
Sbjct: 214 TTEDKGWWEGECQ-GRRGVFPDNFVLPPPPIKKLV 247
Score = 35.0 bits (79), Expect = 0.082
Identities = 16/44 (36%), Positives = 26/44 (59%)
Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNP 299
L L+ G+IV++ + +G W G+ NG+ G FP V++ D P
Sbjct: 102 LKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 59.3 bits (142), Expect = 4e-09
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)
Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
+S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+
Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
+ + + + F L L +H+ T TTL PAP+ P + VS
Sbjct: 211 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 260
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 59.3 bits (142), Expect = 4e-09
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)
Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
+S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+
Sbjct: 166 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225
Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
+ + + + F L L +H+ T TTL PAP+ P + VS
Sbjct: 226 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 275
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 59.3 bits (142), Expect = 4e-09
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)
Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
+S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+
Sbjct: 145 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204
Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
+ + + + F L L +H+ T TTL PAP+ P + VS
Sbjct: 205 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 254
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 59.3 bits (142), Expect = 4e-09
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)
Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
+S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+
Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
+ + + + F L L +H+ T TTL PAP+ P + VS
Sbjct: 211 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 260
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 59.3 bits (142), Expect = 4e-09
Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)
Query: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
+S ++ +WY GPVSR A+ L +G FLVR+S + PG +S+ RV HY IN+
Sbjct: 130 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189
Query: 67 PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
+ + + + F L L +H+ T TTL PAP+ P + VS
Sbjct: 190 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 239
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 58.5 bits (140), Expect = 7e-09
Identities = 54/215 (25%), Positives = 88/215 (40%), Gaps = 35/215 (16%)
Query: 7 DSSDRSAWYMGPVSRQEAQTRLQG-QRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINS 65
++ + WY ++R +A+ L R G FLVR + P Y +S ++ H +
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNE-PNSYAISFRAEGKIKHCRVQQ 719
Query: 66 LPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYP------------SPPMGS- 112
+ +G+ EFD L L+ +Y+ H L + RYP P G+
Sbjct: 720 -EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKL----RYPINEEALEKIGTAEPDYGAL 774
Query: 113 ---------VSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSA 163
V A +PT + V+ L+D+ ++L F K I+ +EK E WW
Sbjct: 775 YEGRNPGFYVEANPMPTFKCA---VKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRG 831
Query: 164 RNKDGRVGMIPVPYVEKLVRS---SPHGKHGNRNS 195
+ P YVE++V P +H + NS
Sbjct: 832 DYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENS 866
Score = 36.6 bits (83), Expect = 0.028
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 4/64 (6%)
Query: 30 GQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPN----RRFKIGDQEFDHLPALL 85
G G FLVR+S T GDY LS N +V H I+S + + F + FD L L+
Sbjct: 577 GAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLI 636
Query: 86 EFYK 89
Y+
Sbjct: 637 THYQ 640
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 58.5 bits (140), Expect = 7e-09
Identities = 54/215 (25%), Positives = 88/215 (40%), Gaps = 35/215 (16%)
Query: 7 DSSDRSAWYMGPVSRQEAQTRLQG-QRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINS 65
++ + WY ++R +A+ L R G FLVR + P Y +S ++ H +
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNE-PNSYAISFRAEGKIKHCRVQQ 719
Query: 66 LPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYP------------SPPMGS- 112
+ +G+ EFD L L+ +Y+ H L + RYP P G+
Sbjct: 720 -EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKL----RYPINEEALEKIGTAEPDYGAL 774
Query: 113 ---------VSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSA 163
V A +PT + V+ L+D+ ++L F K I+ +EK E WW
Sbjct: 775 YEGRNPGFYVEANPMPTFKCA---VKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRG 831
Query: 164 RNKDGRVGMIPVPYVEKLVRS---SPHGKHGNRNS 195
+ P YVE++V P +H + NS
Sbjct: 832 DYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENS 866
Score = 36.6 bits (83), Expect = 0.028
Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 4/64 (6%)
Query: 30 GQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPN----RRFKIGDQEFDHLPALL 85
G G FLVR+S T GDY LS N +V H I+S + + F + FD L L+
Sbjct: 577 GAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLI 636
Query: 86 EFYK 89
Y+
Sbjct: 637 THYQ 640
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 58.2 bits (139), Expect = 9e-09
Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)
Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
++TL + P G+ LP + +YDF +++L FKKG+ + I+
Sbjct: 235 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 286
Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
K ++ W+ + GRVG+ P+ YVEKL PE A A+P
Sbjct: 287 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 323
Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
P PA G G +AI K A L+L GD V + +
Sbjct: 324 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 367
Query: 275 WEGEVNG--RKGLFPFTHVKI 293
+EG++ G R+G+FP ++V++
Sbjct: 368 YEGKIPGTNRQGIFPVSYVEV 388
Score = 32.3 bits (72), Expect = 0.53
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
L+ + GD V + R +EGE +GR G+FP ++V+ P
Sbjct: 274 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314
Score = 30.0 bits (66), Expect = 2.6
Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)
Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
A YP PP+ S + P P +N+ E + LY++ + ++L +
Sbjct: 396 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 455
Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
+ +++ ++EK ++ W+ ++ + G P YV++L
Sbjct: 456 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 58.2 bits (139), Expect = 9e-09
Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)
Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
++TL + P G+ LP + +YDF +++L FKKG+ + I+
Sbjct: 747 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 798
Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
K ++ W+ + GRVG+ P+ YVEKL PE A A+P
Sbjct: 799 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 835
Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
P PA G G +AI K A L+L GD V + +
Sbjct: 836 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 879
Query: 275 WEGEVNG--RKGLFPFTHVKI 293
+EG++ G R+G+FP ++V++
Sbjct: 880 YEGKIPGTNRQGIFPVSYVEV 900
Score = 32.3 bits (72), Expect = 0.53
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
L+ + GD V + R +EGE +GR G+FP ++V+ P
Sbjct: 786 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826
Score = 30.0 bits (66), Expect = 2.6
Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)
Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
A YP PP+ S + P P +N+ E + LY++ + ++L +
Sbjct: 908 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 967
Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
+ +++ ++EK ++ W+ ++ + G P YV++L
Sbjct: 968 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 58.2 bits (139), Expect = 9e-09
Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)
Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
++TL + P G+ LP + +YDF +++L FKKG+ + I+
Sbjct: 567 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 618
Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
K ++ W+ + GRVG+ P+ YVEKL PE A A+P
Sbjct: 619 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 655
Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
P PA G G +AI K A L+L GD V + +
Sbjct: 656 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 699
Query: 275 WEGEVNG--RKGLFPFTHVKI 293
+EG++ G R+G+FP ++V++
Sbjct: 700 YEGKIPGTNRQGIFPVSYVEV 720
Score = 32.3 bits (72), Expect = 0.53
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
L+ + GD V + R +EGE +GR G+FP ++V+ P
Sbjct: 606 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646
Score = 30.0 bits (66), Expect = 2.6
Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)
Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
A YP PP+ S + P P +N+ E + LY++ + ++L +
Sbjct: 728 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 787
Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
+ +++ ++EK ++ W+ ++ + G P YV++L
Sbjct: 788 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 58.2 bits (139), Expect = 9e-09
Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)
Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
++TL + P G+ LP + +YDF +++L FKKG+ + I+
Sbjct: 404 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 455
Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
K ++ W+ + GRVG+ P+ YVEKL PE A A+P
Sbjct: 456 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 492
Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
P PA G G +AI K A L+L GD V + +
Sbjct: 493 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 536
Query: 275 WEGEVNG--RKGLFPFTHVKI 293
+EG++ G R+G+FP ++V++
Sbjct: 537 YEGKIPGTNRQGIFPVSYVEV 557
Score = 32.3 bits (72), Expect = 0.53
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
L+ + GD V + R +EGE +GR G+FP ++V+ P
Sbjct: 443 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483
Score = 30.0 bits (66), Expect = 2.6
Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)
Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
A YP PP+ S + P P +N+ E + LY++ + ++L +
Sbjct: 565 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 624
Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
+ +++ ++EK ++ W+ ++ + G P YV++L
Sbjct: 625 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 58.2 bits (139), Expect = 9e-09
Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)
Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
++TL + P G+ LP + +YDF +++L FKKG+ + I+
Sbjct: 474 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 525
Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
K ++ W+ + GRVG+ P+ YVEKL PE A A+P
Sbjct: 526 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 562
Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
P PA G G +AI K A L+L GD V + +
Sbjct: 563 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 606
Query: 275 WEGEVNG--RKGLFPFTHVKI 293
+EG++ G R+G+FP ++V++
Sbjct: 607 YEGKIPGTNRQGIFPVSYVEV 627
Score = 32.3 bits (72), Expect = 0.53
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
L+ + GD V + R +EGE +GR G+FP ++V+ P
Sbjct: 513 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553
Score = 30.0 bits (66), Expect = 2.6
Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)
Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
A YP PP+ S + P P +N+ E + LY++ + ++L +
Sbjct: 635 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 694
Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
+ +++ ++EK ++ W+ ++ + G P YV++L
Sbjct: 695 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 58.2 bits (139), Expect = 9e-09
Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)
Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
++TL + P G+ LP + +YDF +++L FKKG+ + I+
Sbjct: 387 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 438
Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
K ++ W+ + GRVG+ P+ YVEKL PE A A+P
Sbjct: 439 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 475
Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
P PA G G +AI K A L+L GD V + +
Sbjct: 476 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 519
Query: 275 WEGEVNG--RKGLFPFTHVKI 293
+EG++ G R+G+FP ++V++
Sbjct: 520 YEGKIPGTNRQGIFPVSYVEV 540
Score = 32.3 bits (72), Expect = 0.53
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
L+ + GD V + R +EGE +GR G+FP ++V+ P
Sbjct: 426 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466
Score = 30.0 bits (66), Expect = 2.6
Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)
Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
A YP PP+ S + P P +N+ E + LY++ + ++L +
Sbjct: 548 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 607
Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
+ +++ ++EK ++ W+ ++ + G P YV++L
Sbjct: 608 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 58.2 bits (139), Expect = 9e-09
Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)
Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
++TL + P G+ LP + +YDF +++L FKKG+ + I+
Sbjct: 843 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 894
Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
K ++ W+ + GRVG+ P+ YVEKL PE A A+P
Sbjct: 895 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 931
Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
P PA G G +AI K A L+L GD V + +
Sbjct: 932 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 975
Query: 275 WEGEVNG--RKGLFPFTHVKI 293
+EG++ G R+G+FP ++V++
Sbjct: 976 YEGKIPGTNRQGIFPVSYVEV 996
Score = 32.3 bits (72), Expect = 0.53
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
L+ + GD V + R +EGE +GR G+FP ++V+ P
Sbjct: 882 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922
Score = 30.0 bits (66), Expect = 2.6
Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)
Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
A YP PP+ S + P P +N+ E + LY++ + ++L +
Sbjct: 1004 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 1063
Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
+ +++ ++EK ++ W+ ++ + G P YV++L
Sbjct: 1064 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 58.2 bits (139), Expect = 9e-09
Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)
Query: 95 TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
++TL + P G+ LP + +YDF +++L FKKG+ + I+
Sbjct: 409 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 460
Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
K ++ W+ + GRVG+ P+ YVEKL PE A A+P
Sbjct: 461 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 497
Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
P PA G G +AI K A L+L GD V + +
Sbjct: 498 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 541
Query: 275 WEGEVNG--RKGLFPFTHVKI 293
+EG++ G R+G+FP ++V++
Sbjct: 542 YEGKIPGTNRQGIFPVSYVEV 562
Score = 32.3 bits (72), Expect = 0.53
Identities = 15/41 (36%), Positives = 24/41 (58%)
Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
L+ + GD V + R +EGE +GR G+FP ++V+ P
Sbjct: 448 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 488
Score = 30.0 bits (66), Expect = 2.6
Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)
Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
A YP PP+ S + P P +N+ E + LY++ + ++L +
Sbjct: 570 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 629
Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
+ +++ ++EK ++ W+ ++ + G P YV++L
Sbjct: 630 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 57.8 bits (138), Expect = 1e-08
Identities = 38/99 (38%), Positives = 51/99 (51%), Gaps = 19/99 (19%)
Query: 125 LEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEE--QWWSARNKDGRVGMIPVPYVEKLV 182
L V+TLY F E+L F+KGE + +IEKPE +WW +N G+VG++P YV +V
Sbjct: 197 LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV--VV 254
Query: 183 RSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSG 221
S H PAHA PQ + P+ SG
Sbjct: 255 LSDGPALH------------PAHA---PQISYTGPSSSG 278
Score = 50.4 bits (119), Expect = 2e-06
Identities = 47/166 (28%), Positives = 67/166 (40%), Gaps = 17/166 (10%)
Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191
+D+ ++L KK E L +++ + WW RN R G +P YVE+ S G
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDD-SKTWWRVRNAANRTGYVPSNYVER-KNSLKKGSLV 68
Query: 192 NRNSNSYGIPEPAH------AYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQK 245
++ G+ + A P T PA +GS I L N P F K
Sbjct: 69 KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPA-NGSGADRIYDL----NIPAFVKFAY- 122
Query: 246 RVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHV 291
A + L+L G V V +G W G NG+ G FP +V
Sbjct: 123 ---VAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYV 165
Score = 48.9 bits (115), Expect = 5e-06
Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 5/89 (5%)
Query: 2 SSARFDSSDRSAWYMGPVSRQEAQTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSH 60
SS RF + WY G V+R +A+ L + G FL+RDS + P D+ +S+ + + H
Sbjct: 276 SSGRFAGRE---WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKH 332
Query: 61 YIINSLPNRRFKIGDQEFDHLPALLEFYK 89
+ + + N + IG + F + L+E YK
Sbjct: 333 FKVQLVDN-VYCIGQRRFHTMDELVEHYK 360
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 57.8 bits (138), Expect = 1e-08
Identities = 38/99 (38%), Positives = 51/99 (51%), Gaps = 19/99 (19%)
Query: 125 LEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEE--QWWSARNKDGRVGMIPVPYVEKLV 182
L V+TLY F E+L F+KGE + +IEKPE +WW +N G+VG++P YV +V
Sbjct: 197 LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV--VV 254
Query: 183 RSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSG 221
S H PAHA PQ + P+ SG
Sbjct: 255 LSDGPALH------------PAHA---PQISYTGPSSSG 278
Score = 50.4 bits (119), Expect = 2e-06
Identities = 47/166 (28%), Positives = 67/166 (40%), Gaps = 17/166 (10%)
Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191
+D+ ++L KK E L +++ + WW RN R G +P YVE+ S G
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDD-SKTWWRVRNAANRTGYVPSNYVER-KNSLKKGSLV 68
Query: 192 NRNSNSYGIPEPAH------AYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQK 245
++ G+ + A P T PA +GS I L N P F K
Sbjct: 69 KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPA-NGSGADRIYDL----NIPAFVKFAY- 122
Query: 246 RVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHV 291
A + L+L G V V +G W G NG+ G FP +V
Sbjct: 123 ---VAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYV 165
Score = 48.9 bits (115), Expect = 5e-06
Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 5/89 (5%)
Query: 2 SSARFDSSDRSAWYMGPVSRQEAQTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSH 60
SS RF + WY G V+R +A+ L + G FL+RDS + P D+ +S+ + + H
Sbjct: 276 SSGRFAGRE---WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKH 332
Query: 61 YIINSLPNRRFKIGDQEFDHLPALLEFYK 89
+ + + N + IG + F + L+E YK
Sbjct: 333 FKVQLVDN-VYCIGQRRFHTMDELVEHYK 360
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,489,964
Number of Sequences: 37866
Number of extensions: 724049
Number of successful extensions: 3634
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 287
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 2831
Number of HSP's gapped (non-prelim): 739
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.