Guide to the Human Genome
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Search of human proteins with 4885153

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885153 v-crk sarcoma virus CT10 oncogene homolog
(avian)-like [Homo sapiens]
         (303 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik...   628   e-180
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ...   345   2e-95
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ...   231   6e-61
gi|5729856 GRB2-related adaptor protein [Homo sapiens]                 89   4e-18
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     72   5e-13
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    72   6e-13
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ...    69   5e-12
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...    69   5e-12
gi|11321634 CD2-associated protein [Homo sapiens]                      65   1e-10
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...    63   3e-10
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...    60   2e-09
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...    60   2e-09
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H...    60   2e-09
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]              59   4e-09
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]                59   4e-09
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]              59   4e-09
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]              59   4e-09
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]              59   4e-09
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]          59   7e-09
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]          59   7e-09
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ...    58   9e-09
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ...    58   9e-09
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ...    58   9e-09
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ...    58   9e-09
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ...    58   9e-09
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ...    58   9e-09
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s...    58   9e-09
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ...    58   9e-09
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]             58   1e-08
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]             58   1e-08

>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
           [Homo sapiens]
          Length = 303

 Score =  628 bits (1620), Expect = e-180
 Identities = 303/303 (100%), Positives = 303/303 (100%)

Query: 1   MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH 60
           MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH
Sbjct: 1   MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSH 60

Query: 61  YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT 120
           YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT
Sbjct: 61  YIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPT 120

Query: 121 AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
           AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK
Sbjct: 121 AEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180

Query: 181 LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA 240
           LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA
Sbjct: 181 LVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFA 240

Query: 241 KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD 300
           KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD
Sbjct: 241 KAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNPD 300

Query: 301 ENE 303
           ENE
Sbjct: 301 ENE 303


>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
           [Homo sapiens]
          Length = 304

 Score =  345 bits (886), Expect = 2e-95
 Identities = 184/323 (56%), Positives = 217/323 (67%), Gaps = 45/323 (13%)

Query: 3   SARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYI 62
           +  FDS +RS+WY G +SRQEA   LQGQRHG+FLVRDSST PGDYVLSVSENSRVSHYI
Sbjct: 2   AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYI 61

Query: 63  INSLPNR-----------------RFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY 105
           INS   R                 R +IGDQEFD LPALLEFYKIHYLDTTTLIEP  R 
Sbjct: 62  INSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR- 120

Query: 106 PSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN 165
                 S     +   ++  EYVR L+DF GND EDLPFKKG+IL I +KPEEQWW+A +
Sbjct: 121 ------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174

Query: 166 KDGRVGMIPVPYVEKLVRSSPH------GKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAV 219
            +G+ GMIPVPYVEK   +S        G     +    G PEP   YAQP   TPLP  
Sbjct: 175 SEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPG-PYAQPSVNTPLP-- 231

Query: 220 SGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEV 279
                       + QNGP++A+ IQKRVP AYDKTALALEVG++VKVT++N++GQWEGE 
Sbjct: 232 ------------NLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGEC 279

Query: 280 NGRKGLFPFTHVKIFDPQNPDEN 302
           NG++G FPFTHV++ D QNPDE+
Sbjct: 280 NGKRGHFPFTHVRLLDQQNPDED 302


>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
           [Homo sapiens]
          Length = 204

 Score =  231 bits (589), Expect = 6e-61
 Identities = 121/195 (62%), Positives = 137/195 (70%), Gaps = 24/195 (12%)

Query: 3   SARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYI 62
           +  FDS +RS+WY G +SRQEA   LQGQRHG+FLVRDSST PGDYVLSVSENSRVSHYI
Sbjct: 2   AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYI 61

Query: 63  INSLPNR-----------------RFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY 105
           INS   R                 R +IGDQEFD LPALLEFYKIHYLDTTTLIEP  R 
Sbjct: 62  INSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR- 120

Query: 106 PSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN 165
                 S     +   ++  EYVR L+DF GND EDLPFKKG+IL I +KPEEQWW+A +
Sbjct: 121 ------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174

Query: 166 KDGRVGMIPVPYVEK 180
            +G+ GMIPVPYVEK
Sbjct: 175 SEGKRGMIPVPYVEK 189


>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
          Length = 217

 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 48/167 (28%), Positives = 90/167 (53%), Gaps = 14/167 (8%)

Query: 14  WYMGPVSRQEAQTRLQGQRH-GMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFK 72
           WY G +SRQ A+  L  + H G FL+R+S + PG++ +SV+   +V H+ +    + ++ 
Sbjct: 60  WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYF 119

Query: 73  IGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLY 132
           + +++F+ L  L++FY+     TTT+ +    +       + +P          + +  +
Sbjct: 120 LWEEKFNSLNELVDFYR-----TTTIAKKRQIFLRDEEPLLKSPGAC-------FAQAQF 167

Query: 133 DFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVE 179
           DF   D   L F++G+I+ ++E+P+  WW  R+  GRVG  P  YV+
Sbjct: 168 DFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRS-CGRVGFFPRSYVQ 213



 Score = 38.5 bits (88), Expect = 0.007
 Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 4/65 (6%)

Query: 131 LYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKH 190
           LY F   ++++L F KG+ L I+   ++Q W      G  G IP  Y    +R  PH  +
Sbjct: 6   LYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNY----IRVKPHPWY 61

Query: 191 GNRNS 195
             R S
Sbjct: 62  SGRIS 66



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 15/43 (34%), Positives = 22/43 (51%)

Query: 250 AYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVK 292
           A D + L+   GDI++V        W G   GR G FP ++V+
Sbjct: 171 AQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQ 213


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 49/170 (28%), Positives = 79/170 (46%), Gaps = 4/170 (2%)

Query: 14  WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
           WY GP+ R  A++ L  +  G FLVR       ++ +S+  N  V H  I +        
Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRIT 730

Query: 74  GDQEFDHLPALLEFYKIHYL-DTTTLIEPAPRYP--SPPMGSVSAPNLPTAEDNLEYVRT 130
             + F  L  L+EFY+ + L D    ++   ++P   P   ++S P + + +      + 
Sbjct: 731 EKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTISRPAVGSTK-YFGTAKA 789

Query: 131 LYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
            YDF   D  +L  K+G+I+ I+ K  +Q W      GRVG  P  YVE+
Sbjct: 790 RYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYVEE 839



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 22/63 (34%), Positives = 35/63 (55%), Gaps = 1/63 (1%)

Query: 231 PSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFT 289
           P+  +   F  A  +   CA D++ L+L+ GDI+K+  +    G W GE+ GR G FP  
Sbjct: 776 PAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPAN 835

Query: 290 HVK 292
           +V+
Sbjct: 836 YVE 838


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 72.0 bits (175), Expect = 6e-13
 Identities = 45/177 (25%), Positives = 84/177 (47%), Gaps = 26/177 (14%)

Query: 14  WYMGPVSRQEAQTRLQGQRH-GMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFK 72
           W+ G + R +A+  L  QRH G FL+R+S + PGD+ LSV   + V H+ +      ++ 
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119

Query: 73  IGDQEFDHLPALLEFYKIHYLDTTTLI-----EPAPRYPSPPMGSVSAPNLPTAEDNLEY 127
           +   +F+ L  L+++++   +     I     E  P+ P+                   Y
Sbjct: 120 LWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPT-------------------Y 160

Query: 128 VRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRS 184
           V+ L+DF   +  +L F++G+ + +++  +  WW      G+ GM P  YV  + R+
Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA-CHGQTGMFPRNYVTPVNRN 216



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 17/48 (35%), Positives = 28/48 (58%)

Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVE 179
           YDF     ++L FK+G+IL ++ +  +Q W     +G+ G IP  Y+E
Sbjct: 7   YDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54


>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 287

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 51/175 (29%), Positives = 78/175 (44%), Gaps = 9/175 (5%)

Query: 14  WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
           WY G + R +A+T L  + +  +LVR  +   G+Y +S+  N+   H  I +        
Sbjct: 112 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 171

Query: 74  GDQEFDHLPALLEFYKIHYLDT------TTLIEP--APRYPSPPMGSVSAPNLPTAEDNL 125
            +++F  L  L+E+YK H L        TTL  P   P + +   G+  A N   +   L
Sbjct: 172 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGN-RAGNSLLSPKVL 230

Query: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
                 YDF   D  +L   KG+++ I  K     W     +GRVG  P  YVE+
Sbjct: 231 GIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEE 285



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 28/56 (50%), Positives = 36/56 (64%), Gaps = 1/56 (1%)

Query: 238 VFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFTHVK 292
           V   AI +   CA D   L+L  GD+VK+ T+M+ NG W GEVNGR G FP T+V+
Sbjct: 229 VLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 284


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 51/175 (29%), Positives = 78/175 (44%), Gaps = 9/175 (5%)

Query: 14  WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
           WY G + R +A+T L  + +  +LVR  +   G+Y +S+  N+   H  I +        
Sbjct: 672 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIA 731

Query: 74  GDQEFDHLPALLEFYKIHYLDT------TTLIEP--APRYPSPPMGSVSAPNLPTAEDNL 125
            +++F  L  L+E+YK H L        TTL  P   P + +   G+  A N   +   L
Sbjct: 732 ENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHSAGQRGN-RAGNSLLSPKVL 790

Query: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEK 180
                 YDF   D  +L   KG+++ I  K     W     +GRVG  P  YVE+
Sbjct: 791 GIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEE 845



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 28/56 (50%), Positives = 36/56 (64%), Gaps = 1/56 (1%)

Query: 238 VFAKAIQKRVPCAYDKTALALEVGDIVKV-TRMNINGQWEGEVNGRKGLFPFTHVK 292
           V   AI +   CA D   L+L  GD+VK+ T+M+ NG W GEVNGR G FP T+V+
Sbjct: 789 VLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVE 844


>gi|11321634 CD2-associated protein [Homo sapiens]
          Length = 639

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 44/164 (26%), Positives = 72/164 (43%), Gaps = 11/164 (6%)

Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191
           YD+     ++L  + GEI+  ++K +E+ W     +GR GM P  +V+++ R +      
Sbjct: 8   YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRET------ 61

Query: 192 NRNSNSYGIPEPAHAYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAY 251
                   +P     +    +     +  G P   I P P T+N     K  Q +V   Y
Sbjct: 62  --EFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEY 119

Query: 252 ---DKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVK 292
              ++  L L+VGDI+ +      G W G +N + GLFP   VK
Sbjct: 120 IPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVK 163



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 3/51 (5%)

Query: 126 EYVRTLYDFPGNDAEDLPFKKGEILVIIEKP--EEQWWSARNKDGRVGMIP 174
           EY RTL+ + G + ++L FK+GEI+ +I K   E  WW     +G+ G+ P
Sbjct: 272 EYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRG-ELNGKEGVFP 321



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 48/219 (21%), Positives = 87/219 (39%), Gaps = 71/219 (32%)

Query: 129 RTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHG 188
           + L+++   + ++L  K G+I+ I E+ EE WWS    + ++G+ P  +V++L  +    
Sbjct: 114 KVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSG-TLNNKLGLFPSNFVKELEVTDDGE 172

Query: 189 KHGNRNSNSYGIPEPAHAYAQPQTTTPLPA---VSGSPGAAIT----------------- 228
            H  ++ +   +  P         T+P+P+   VS +   ++T                 
Sbjct: 173 THEAQDDSETVLAGP---------TSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEG 223

Query: 229 --------------------PL------PSTQN---------GPVFAKAIQKRVPCAYDK 253
                               PL      P TQ+         G + AK    R   AY+ 
Sbjct: 224 SVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKE-YCRTLFAYEG 282

Query: 254 T---ALALEVGDIVKVTRMNIN--GQWEGEVNGRKGLFP 287
           T    L  + G+I+ +        G W GE+NG++G+FP
Sbjct: 283 TNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFP 321


>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 44/176 (25%), Positives = 74/176 (42%), Gaps = 12/176 (6%)

Query: 14  WYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKI 73
           W+ G + RQ+    L+    G +L+R+       + +S+  N  V H  +    N     
Sbjct: 663 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHIT 722

Query: 74  GDQEFDHLPALLEFYKIH-------YLDTTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLE 126
             ++FD L  L+E+Y+ H        LDTT       R  S    S  +P          
Sbjct: 723 EAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTA 782

Query: 127 YVRTLYDFPGNDAEDLPFKKGEILVIIEK--PEEQWWSARNKDGRVGMIPVPYVEK 180
             R  Y+F   D  +L  ++G+++ I  +   ++ WW     +GR+G  P  YVE+
Sbjct: 783 VAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGET-NGRIGWFPSTYVEE 835



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 29/90 (32%), Positives = 41/90 (45%), Gaps = 3/90 (3%)

Query: 206 AYAQPQTTTPLPAVSGSPGAAITPLPSTQNGP-VFAKAIQKRVPCAYDKTALALEVGDIV 264
           ++ Q  TT   P  S    A+     S    P V   A+ +    A D   L+L  GD+V
Sbjct: 745 SFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIGTAVARYNFAARDMRELSLREGDVV 804

Query: 265 KVTRM--NINGQWEGEVNGRKGLFPFTHVK 292
           ++        G W+GE NGR G FP T+V+
Sbjct: 805 RIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 41/118 (34%), Positives = 61/118 (51%), Gaps = 13/118 (11%)

Query: 7   DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
           +S ++ +WY GPVSR  A+  L    +G FLVR+S + PG   +S+    RV HY IN+ 
Sbjct: 120 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 179

Query: 67  PNRRFKI-GDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVSAPN 117
            + +  +  +  F+ L  L     +H+  T      TTL  PAP+   P +  VS PN
Sbjct: 180 SDGKLYVSSESRFNTLAEL-----VHHHSTVADGLITTLHYPAPKRNKPTVYGVS-PN 231



 Score = 29.3 bits (64), Expect = 4.5
 Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 5/72 (6%)

Query: 131 LYDFPGNDAEDLPFKKGEIL-VIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHG- 188
           LYDF  +    L   KGE L V+      +W  A+ K+G+ G +P  Y+  +     H  
Sbjct: 69  LYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEKHSW 127

Query: 189 KHG--NRNSNSY 198
            HG  +RN+  Y
Sbjct: 128 YHGPVSRNAAEY 139


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 41/118 (34%), Positives = 61/118 (51%), Gaps = 13/118 (11%)

Query: 7   DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
           +S ++ +WY GPVSR  A+  L    +G FLVR+S + PG   +S+    RV HY IN+ 
Sbjct: 139 NSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 198

Query: 67  PNRRFKI-GDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVSAPN 117
            + +  +  +  F+ L  L     +H+  T      TTL  PAP+   P +  VS PN
Sbjct: 199 SDGKLYVSSESRFNTLAEL-----VHHHSTVADGLITTLHYPAPKRNKPTVYGVS-PN 250



 Score = 29.3 bits (64), Expect = 4.5
 Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 5/72 (6%)

Query: 131 LYDFPGNDAEDLPFKKGEIL-VIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHG- 188
           LYDF  +    L   KGE L V+      +W  A+ K+G+ G +P  Y+  +     H  
Sbjct: 88  LYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEKHSW 146

Query: 189 KHG--NRNSNSY 198
            HG  +RN+  Y
Sbjct: 147 YHGPVSRNAAEY 158


>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
           sapiens]
          Length = 756

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 48/159 (30%), Positives = 75/159 (47%), Gaps = 20/159 (12%)

Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191
           + +    A++L  + GEI+ +I++ E+ WW  + K+G++G  P  +VE L    P     
Sbjct: 92  FSYSPEQADELKLQAGEIVEMIKEIEDGWWLGK-KNGQLGAFPSNFVELLDSGPP----- 145

Query: 192 NRNSNSYGIPEPAHAYAQPQTTTPLPAVS-GSPGAAITPLPSTQNGPVFAKAIQKRVPCA 250
                S G P+       PQ    L +++  SP   +     T + P   + +    P A
Sbjct: 146 -----SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYL----QTVSHPEVYRVLFDYQPEA 196

Query: 251 YDKTALALEVGDIVKVTRMNIN--GQWEGEVNGRKGLFP 287
            D+  LAL  GD+VKV        G WEGE  GR+G+FP
Sbjct: 197 PDE--LALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFP 233



 Score = 37.4 bits (85), Expect = 0.017
 Identities = 25/95 (26%), Positives = 47/95 (49%), Gaps = 13/95 (13%)

Query: 99  IEPAPRYPSPPMGSV---SAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEK 155
           + P P+ P P + S+   S P+      + E  R L+D+     ++L  ++G+++ ++ K
Sbjct: 155 VSPGPQRP-PKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSK 213

Query: 156 PEEQ--WWSARNKDGRVG------MIPVPYVEKLV 182
             E   WW    + GR G      ++P P ++KLV
Sbjct: 214 TTEDKGWWEGECQ-GRRGVFPDNFVLPPPPIKKLV 247



 Score = 35.0 bits (79), Expect = 0.082
 Identities = 16/44 (36%), Positives = 26/44 (59%)

Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDPQNP 299
           L L+ G+IV++ +   +G W G+ NG+ G FP   V++ D   P
Sbjct: 102 LKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)

Query: 7   DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
           +S ++ +WY GPVSR  A+  L    +G FLVR+S + PG   +S+    RV HY IN+ 
Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210

Query: 67  PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
            + + +   +  F  L  L     +H+  T      TTL  PAP+   P +  VS
Sbjct: 211 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 260


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)

Query: 7   DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
           +S ++ +WY GPVSR  A+  L    +G FLVR+S + PG   +S+    RV HY IN+ 
Sbjct: 166 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225

Query: 67  PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
            + + +   +  F  L  L     +H+  T      TTL  PAP+   P +  VS
Sbjct: 226 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 275


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)

Query: 7   DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
           +S ++ +WY GPVSR  A+  L    +G FLVR+S + PG   +S+    RV HY IN+ 
Sbjct: 145 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204

Query: 67  PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
            + + +   +  F  L  L     +H+  T      TTL  PAP+   P +  VS
Sbjct: 205 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 254


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)

Query: 7   DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
           +S ++ +WY GPVSR  A+  L    +G FLVR+S + PG   +S+    RV HY IN+ 
Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210

Query: 67  PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
            + + +   +  F  L  L     +H+  T      TTL  PAP+   P +  VS
Sbjct: 211 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 260


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 12/115 (10%)

Query: 7   DSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSL 66
           +S ++ +WY GPVSR  A+  L    +G FLVR+S + PG   +S+    RV HY IN+ 
Sbjct: 130 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189

Query: 67  PNRR-FKIGDQEFDHLPALLEFYKIHYLDT------TTLIEPAPRYPSPPMGSVS 114
            + + +   +  F  L  L     +H+  T      TTL  PAP+   P +  VS
Sbjct: 190 ADGKVYVTAESRFSTLAEL-----VHHHSTVADGLVTTLHYPAPKCNKPTVYGVS 239


>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
          Length = 1291

 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 54/215 (25%), Positives = 88/215 (40%), Gaps = 35/215 (16%)

Query: 7   DSSDRSAWYMGPVSRQEAQTRLQG-QRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINS 65
           ++ +   WY   ++R +A+  L    R G FLVR  +  P  Y +S     ++ H  +  
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNE-PNSYAISFRAEGKIKHCRVQQ 719

Query: 66  LPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYP------------SPPMGS- 112
              +   +G+ EFD L  L+ +Y+ H L     +    RYP             P  G+ 
Sbjct: 720 -EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKL----RYPINEEALEKIGTAEPDYGAL 774

Query: 113 ---------VSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSA 163
                    V A  +PT +     V+ L+D+     ++L F K  I+  +EK E  WW  
Sbjct: 775 YEGRNPGFYVEANPMPTFKCA---VKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRG 831

Query: 164 RNKDGRVGMIPVPYVEKLVRS---SPHGKHGNRNS 195
                +    P  YVE++V      P  +H + NS
Sbjct: 832 DYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENS 866



 Score = 36.6 bits (83), Expect = 0.028
 Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 4/64 (6%)

Query: 30  GQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPN----RRFKIGDQEFDHLPALL 85
           G   G FLVR+S T  GDY LS   N +V H  I+S  +    + F   +  FD L  L+
Sbjct: 577 GAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLI 636

Query: 86  EFYK 89
             Y+
Sbjct: 637 THYQ 640


>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
          Length = 1290

 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 54/215 (25%), Positives = 88/215 (40%), Gaps = 35/215 (16%)

Query: 7   DSSDRSAWYMGPVSRQEAQTRLQG-QRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINS 65
           ++ +   WY   ++R +A+  L    R G FLVR  +  P  Y +S     ++ H  +  
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNE-PNSYAISFRAEGKIKHCRVQQ 719

Query: 66  LPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRYP------------SPPMGS- 112
              +   +G+ EFD L  L+ +Y+ H L     +    RYP             P  G+ 
Sbjct: 720 -EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKL----RYPINEEALEKIGTAEPDYGAL 774

Query: 113 ---------VSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSA 163
                    V A  +PT +     V+ L+D+     ++L F K  I+  +EK E  WW  
Sbjct: 775 YEGRNPGFYVEANPMPTFKCA---VKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRG 831

Query: 164 RNKDGRVGMIPVPYVEKLVRS---SPHGKHGNRNS 195
                +    P  YVE++V      P  +H + NS
Sbjct: 832 DYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENS 866



 Score = 36.6 bits (83), Expect = 0.028
 Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 4/64 (6%)

Query: 30  GQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPN----RRFKIGDQEFDHLPALL 85
           G   G FLVR+S T  GDY LS   N +V H  I+S  +    + F   +  FD L  L+
Sbjct: 577 GAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLI 636

Query: 86  EFYK 89
             Y+
Sbjct: 637 THYQ 640


>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
           sapiens]
          Length = 492

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)

Query: 95  TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
           ++TL +     P    G+     LP         + +YDF    +++L FKKG+ + I+ 
Sbjct: 235 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 286

Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
           K ++ W+   +  GRVG+ P+ YVEKL                   PE A   A+P    
Sbjct: 287 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 323

Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
           P PA  G  G                +AI K    A     L+L  GD V + +      
Sbjct: 324 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 367

Query: 275 WEGEVNG--RKGLFPFTHVKI 293
           +EG++ G  R+G+FP ++V++
Sbjct: 368 YEGKIPGTNRQGIFPVSYVEV 388



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 15/41 (36%), Positives = 24/41 (58%)

Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
           L+ + GD V + R      +EGE +GR G+FP ++V+   P
Sbjct: 274 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 314



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)

Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
           A  YP PP+            S + P  P    +N+    E  + LY++   + ++L  +
Sbjct: 396 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 455

Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
           + +++ ++EK ++ W+   ++  +  G  P  YV++L
Sbjct: 456 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492


>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
           sapiens]
          Length = 1004

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)

Query: 95  TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
           ++TL +     P    G+     LP         + +YDF    +++L FKKG+ + I+ 
Sbjct: 747 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 798

Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
           K ++ W+   +  GRVG+ P+ YVEKL                   PE A   A+P    
Sbjct: 799 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 835

Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
           P PA  G  G                +AI K    A     L+L  GD V + +      
Sbjct: 836 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 879

Query: 275 WEGEVNG--RKGLFPFTHVKI 293
           +EG++ G  R+G+FP ++V++
Sbjct: 880 YEGKIPGTNRQGIFPVSYVEV 900



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 15/41 (36%), Positives = 24/41 (58%)

Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
           L+ + GD V + R      +EGE +GR G+FP ++V+   P
Sbjct: 786 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 826



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)

Query: 102  APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
            A  YP PP+            S + P  P    +N+    E  + LY++   + ++L  +
Sbjct: 908  AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 967

Query: 146  KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
            + +++ ++EK ++ W+   ++  +  G  P  YV++L
Sbjct: 968  ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004


>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
           sapiens]
          Length = 824

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)

Query: 95  TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
           ++TL +     P    G+     LP         + +YDF    +++L FKKG+ + I+ 
Sbjct: 567 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 618

Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
           K ++ W+   +  GRVG+ P+ YVEKL                   PE A   A+P    
Sbjct: 619 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 655

Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
           P PA  G  G                +AI K    A     L+L  GD V + +      
Sbjct: 656 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 699

Query: 275 WEGEVNG--RKGLFPFTHVKI 293
           +EG++ G  R+G+FP ++V++
Sbjct: 700 YEGKIPGTNRQGIFPVSYVEV 720



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 15/41 (36%), Positives = 24/41 (58%)

Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
           L+ + GD V + R      +EGE +GR G+FP ++V+   P
Sbjct: 606 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 646



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)

Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
           A  YP PP+            S + P  P    +N+    E  + LY++   + ++L  +
Sbjct: 728 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 787

Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
           + +++ ++EK ++ W+   ++  +  G  P  YV++L
Sbjct: 788 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824


>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
           sapiens]
          Length = 661

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)

Query: 95  TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
           ++TL +     P    G+     LP         + +YDF    +++L FKKG+ + I+ 
Sbjct: 404 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 455

Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
           K ++ W+   +  GRVG+ P+ YVEKL                   PE A   A+P    
Sbjct: 456 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 492

Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
           P PA  G  G                +AI K    A     L+L  GD V + +      
Sbjct: 493 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 536

Query: 275 WEGEVNG--RKGLFPFTHVKI 293
           +EG++ G  R+G+FP ++V++
Sbjct: 537 YEGKIPGTNRQGIFPVSYVEV 557



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 15/41 (36%), Positives = 24/41 (58%)

Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
           L+ + GD V + R      +EGE +GR G+FP ++V+   P
Sbjct: 443 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 483



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)

Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
           A  YP PP+            S + P  P    +N+    E  + LY++   + ++L  +
Sbjct: 565 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 624

Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
           + +++ ++EK ++ W+   ++  +  G  P  YV++L
Sbjct: 625 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661


>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
           sapiens]
          Length = 731

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)

Query: 95  TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
           ++TL +     P    G+     LP         + +YDF    +++L FKKG+ + I+ 
Sbjct: 474 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 525

Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
           K ++ W+   +  GRVG+ P+ YVEKL                   PE A   A+P    
Sbjct: 526 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 562

Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
           P PA  G  G                +AI K    A     L+L  GD V + +      
Sbjct: 563 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 606

Query: 275 WEGEVNG--RKGLFPFTHVKI 293
           +EG++ G  R+G+FP ++V++
Sbjct: 607 YEGKIPGTNRQGIFPVSYVEV 627



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 15/41 (36%), Positives = 24/41 (58%)

Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
           L+ + GD V + R      +EGE +GR G+FP ++V+   P
Sbjct: 513 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 553



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)

Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
           A  YP PP+            S + P  P    +N+    E  + LY++   + ++L  +
Sbjct: 635 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 694

Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
           + +++ ++EK ++ W+   ++  +  G  P  YV++L
Sbjct: 695 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731


>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
           sapiens]
          Length = 644

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)

Query: 95  TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
           ++TL +     P    G+     LP         + +YDF    +++L FKKG+ + I+ 
Sbjct: 387 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 438

Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
           K ++ W+   +  GRVG+ P+ YVEKL                   PE A   A+P    
Sbjct: 439 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 475

Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
           P PA  G  G                +AI K    A     L+L  GD V + +      
Sbjct: 476 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 519

Query: 275 WEGEVNG--RKGLFPFTHVKI 293
           +EG++ G  R+G+FP ++V++
Sbjct: 520 YEGKIPGTNRQGIFPVSYVEV 540



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 15/41 (36%), Positives = 24/41 (58%)

Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
           L+ + GD V + R      +EGE +GR G+FP ++V+   P
Sbjct: 426 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 466



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)

Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
           A  YP PP+            S + P  P    +N+    E  + LY++   + ++L  +
Sbjct: 548 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 607

Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
           + +++ ++EK ++ W+   ++  +  G  P  YV++L
Sbjct: 608 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644


>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
           sapiens]
          Length = 1100

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)

Query: 95  TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
           ++TL +     P    G+     LP         + +YDF    +++L FKKG+ + I+ 
Sbjct: 843 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 894

Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
           K ++ W+   +  GRVG+ P+ YVEKL                   PE A   A+P    
Sbjct: 895 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 931

Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
           P PA  G  G                +AI K    A     L+L  GD V + +      
Sbjct: 932 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 975

Query: 275 WEGEVNG--RKGLFPFTHVKI 293
           +EG++ G  R+G+FP ++V++
Sbjct: 976 YEGKIPGTNRQGIFPVSYVEV 996



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 15/41 (36%), Positives = 24/41 (58%)

Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
           L+ + GD V + R      +EGE +GR G+FP ++V+   P
Sbjct: 882 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 922



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)

Query: 102  APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
            A  YP PP+            S + P  P    +N+    E  + LY++   + ++L  +
Sbjct: 1004 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 1063

Query: 146  KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
            + +++ ++EK ++ W+   ++  +  G  P  YV++L
Sbjct: 1064 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100


>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
           sapiens]
          Length = 666

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 54/201 (26%), Positives = 86/201 (42%), Gaps = 49/201 (24%)

Query: 95  TTTLIEPAPRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
           ++TL +     P    G+     LP         + +YDF    +++L FKKG+ + I+ 
Sbjct: 409 SSTLTDMGRSAPRERRGTPEKEKLPA--------KAVYDFKAQTSKELSFKKGDTVYILR 460

Query: 155 KPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTT 214
           K ++ W+   +  GRVG+ P+ YVEKL                   PE A   A+P    
Sbjct: 461 KIDQNWYEGEH-HGRVGIFPISYVEKLTP-----------------PEKAQP-ARP---- 497

Query: 215 PLPAVSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQ 274
           P PA  G  G                +AI K    A     L+L  GD V + +      
Sbjct: 498 PPPAQPGEIG----------------EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 541

Query: 275 WEGEVNG--RKGLFPFTHVKI 293
           +EG++ G  R+G+FP ++V++
Sbjct: 542 YEGKIPGTNRQGIFPVSYVEV 562



 Score = 32.3 bits (72), Expect = 0.53
 Identities = 15/41 (36%), Positives = 24/41 (58%)

Query: 256 LALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHVKIFDP 296
           L+ + GD V + R      +EGE +GR G+FP ++V+   P
Sbjct: 448 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTP 488



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 21/97 (21%), Positives = 46/97 (47%), Gaps = 17/97 (17%)

Query: 102 APRYPSPPMG-----------SVSAPNLPT-AEDNL----EYVRTLYDFPGNDAEDLPFK 145
           A  YP PP+            S + P  P    +N+    E  + LY++   + ++L  +
Sbjct: 570 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 629

Query: 146 KGEILVIIEKPEEQWWSARNKDGR-VGMIPVPYVEKL 181
           + +++ ++EK ++ W+   ++  +  G  P  YV++L
Sbjct: 630 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666


>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 38/99 (38%), Positives = 51/99 (51%), Gaps = 19/99 (19%)

Query: 125 LEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEE--QWWSARNKDGRVGMIPVPYVEKLV 182
           L  V+TLY F     E+L F+KGE + +IEKPE   +WW  +N  G+VG++P  YV  +V
Sbjct: 197 LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV--VV 254

Query: 183 RSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSG 221
            S     H            PAHA   PQ +   P+ SG
Sbjct: 255 LSDGPALH------------PAHA---PQISYTGPSSSG 278



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 47/166 (28%), Positives = 67/166 (40%), Gaps = 17/166 (10%)

Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191
           +D+     ++L  KK E L +++   + WW  RN   R G +P  YVE+   S   G   
Sbjct: 11  WDYTAQQDQELDIKKNERLWLLDD-SKTWWRVRNAANRTGYVPSNYVER-KNSLKKGSLV 68

Query: 192 NRNSNSYGIPEPAH------AYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQK 245
               ++ G+ +         A   P T    PA +GS    I  L    N P F K    
Sbjct: 69  KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPA-NGSGADRIYDL----NIPAFVKFAY- 122

Query: 246 RVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHV 291
               A  +  L+L  G  V V     +G W G  NG+ G FP  +V
Sbjct: 123 ---VAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYV 165



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 5/89 (5%)

Query: 2   SSARFDSSDRSAWYMGPVSRQEAQTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSH 60
           SS RF   +   WY G V+R +A+  L  +   G FL+RDS + P D+ +S+  + +  H
Sbjct: 276 SSGRFAGRE---WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKH 332

Query: 61  YIINSLPNRRFKIGDQEFDHLPALLEFYK 89
           + +  + N  + IG + F  +  L+E YK
Sbjct: 333 FKVQLVDN-VYCIGQRRFHTMDELVEHYK 360


>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
          Length = 380

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 38/99 (38%), Positives = 51/99 (51%), Gaps = 19/99 (19%)

Query: 125 LEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEE--QWWSARNKDGRVGMIPVPYVEKLV 182
           L  V+TLY F     E+L F+KGE + +IEKPE   +WW  +N  G+VG++P  YV  +V
Sbjct: 197 LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYV--VV 254

Query: 183 RSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAVSG 221
            S     H            PAHA   PQ +   P+ SG
Sbjct: 255 LSDGPALH------------PAHA---PQISYTGPSSSG 278



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 47/166 (28%), Positives = 67/166 (40%), Gaps = 17/166 (10%)

Query: 132 YDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARNKDGRVGMIPVPYVEKLVRSSPHGKHG 191
           +D+     ++L  KK E L +++   + WW  RN   R G +P  YVE+   S   G   
Sbjct: 11  WDYTAQQDQELDIKKNERLWLLDD-SKTWWRVRNAANRTGYVPSNYVER-KNSLKKGSLV 68

Query: 192 NRNSNSYGIPEPAH------AYAQPQTTTPLPAVSGSPGAAITPLPSTQNGPVFAKAIQK 245
               ++ G+ +         A   P T    PA +GS    I  L    N P F K    
Sbjct: 69  KNLKDTLGLGKTRRKTSARDASPTPSTDAEYPA-NGSGADRIYDL----NIPAFVKFAY- 122

Query: 246 RVPCAYDKTALALEVGDIVKVTRMNINGQWEGEVNGRKGLFPFTHV 291
               A  +  L+L  G  V V     +G W G  NG+ G FP  +V
Sbjct: 123 ---VAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYV 165



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 5/89 (5%)

Query: 2   SSARFDSSDRSAWYMGPVSRQEAQTRLQGQR-HGMFLVRDSSTCPGDYVLSVSENSRVSH 60
           SS RF   +   WY G V+R +A+  L  +   G FL+RDS + P D+ +S+  + +  H
Sbjct: 276 SSGRFAGRE---WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKH 332

Query: 61  YIINSLPNRRFKIGDQEFDHLPALLEFYK 89
           + +  + N  + IG + F  +  L+E YK
Sbjct: 333 FKVQLVDN-VYCIGQRRFHTMDELVEHYK 360


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.134    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,489,964
Number of Sequences: 37866
Number of extensions: 724049
Number of successful extensions: 3634
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 287
Number of HSP's successfully gapped in prelim test: 96
Number of HSP's that attempted gapping in prelim test: 2831
Number of HSP's gapped (non-prelim): 739
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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