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Search of human proteins with 4826908
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2
(beta) [Homo sapiens]
(728 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 1481 0.0
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 847 0.0
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 667 0.0
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 659 0.0
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 650 0.0
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 650 0.0
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 65 2e-10
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 65 2e-10
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 65 2e-10
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 64 5e-10
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 64 5e-10
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 64 6e-10
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 64 6e-10
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 58 3e-08
gi|91208437 GEM interacting protein [Homo sapiens] 58 3e-08
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 56 1e-07
gi|195976771 cytokine-inducible SH2-containing protein isoform 1... 55 2e-07
gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ... 55 2e-07
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 55 3e-07
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 55 3e-07
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit... 55 3e-07
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 54 4e-07
gi|4503787 fyn-related kinase [Homo sapiens] 54 5e-07
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 54 5e-07
gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo sap... 54 5e-07
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 54 7e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 53 9e-07
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 53 9e-07
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 53 9e-07
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 53 9e-07
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 1481 bits (3835), Expect = 0.0
Identities = 728/728 (100%), Positives = 728/728 (100%)
Query: 1 MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL 60
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
Sbjct: 1 MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL 60
Query: 61 NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP 120
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
Sbjct: 61 NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP 120
Query: 121 PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA 180
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA
Sbjct: 121 PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLA 180
Query: 181 LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALG 240
LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALG
Sbjct: 181 LPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALG 240
Query: 241 PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP 300
PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP
Sbjct: 241 PAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPP 300
Query: 301 ALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK 360
ALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK
Sbjct: 301 ALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSK 360
Query: 361 IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR 420
IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR
Sbjct: 361 IQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTR 420
Query: 421 LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA 480
LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA
Sbjct: 421 LLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTA 480
Query: 481 IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT 540
IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT
Sbjct: 481 IEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRT 540
Query: 541 KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE 600
KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE
Sbjct: 541 KLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNE 600
Query: 601 TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV 660
TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV
Sbjct: 601 TEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVV 660
Query: 661 VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG 720
VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG
Sbjct: 661 VDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPG 720
Query: 721 PGPPPAAR 728
PGPPPAAR
Sbjct: 721 PGPPPAAR 728
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 847 bits (2189), Expect = 0.0
Identities = 436/735 (59%), Positives = 545/735 (74%), Gaps = 39/735 (5%)
Query: 5 EGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERT 64
EG+QYRALY +++ER ED++L GD+L V++ +L ALG ++G E P+ +GW+ G NE T
Sbjct: 4 EGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETT 63
Query: 65 RQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEP-----GLTLPDLPEQFS 119
+RGDFPGTYVE++G ++ P P+PR PRPLP P E LTLPDL EQF+
Sbjct: 64 GERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAEQFA 123
Query: 120 PPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRT--------DWSLSDVDQWDTAALA 171
PPD+APPLL+KLVEAIE+ GL+ + YR + + D D++ D LA
Sbjct: 124 PPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVHVLA 183
Query: 172 DGIKSFLLALPAPLVTPEASAEARRALREAAGP------VGPALEPPTLPLHRALTLRFL 225
D K +LL LP P++ +E E + + P++P LTL++L
Sbjct: 184 DAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTLQYL 243
Query: 226 LQHLGRVARRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVE 285
L+H ++++ + R L F P+L R S D +E ++E
Sbjct: 244 LKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASS--------DNTENL----IKVIE 291
Query: 286 KLLQEHLEEQEVAPPALPPKPPKAKPAPTVLANGG--SPPSLQDAEWYWGDISREEVNEK 343
L+ E++ AP ALPPKPPK PT +AN G + SLQDAEWYWGDISREEVNEK
Sbjct: 292 ILISTEWNERQPAP-ALPPKPPK----PTTVANNGMNNNMSLQDAEWYWGDISREEVNEK 346
Query: 344 LRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLIN 403
LRDT DGTFLVRDAS+K+ G+YTLTLRKGGNNKLIK+FHRDG YGFS+PLTF SVV+LIN
Sbjct: 347 LRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELIN 406
Query: 404 HYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQL 463
HYR+ESLAQYN KLD +LLYPVSKYQQDQ+VKED++EAVG +L Y+ Q+Q+KSREYD+L
Sbjct: 407 HYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRL 466
Query: 464 YEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILL 523
YEEYTRTSQE+QMKRTAIEAFNETIKIFEEQ QTQE+ SKEY+E+F+REGNEKE+QRI+
Sbjct: 467 YEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMH 526
Query: 524 NSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQ 583
N ++LKSRI+EI +SR +LE+ L+ QA++ REIDKRMNS+KPDL+QLRK RDQYL+WLTQ
Sbjct: 527 NYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQ 586
Query: 584 KGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGT 643
KG RQKK+NEWLG +N TEDQY+L+ED++DLPHH+E+TW VG NR +AE +L GKRDGT
Sbjct: 587 KGVRQKKLNEWLGNEN-TEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGT 645
Query: 644 FLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQ 703
FL+RESS++GCYACSVVVDG+ KHCVI +TATG+GFAEPYNLY SLKELVLHYQH SLVQ
Sbjct: 646 FLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQ 705
Query: 704 HNDALTVTLAHPVRA 718
HND+L VTLA+PV A
Sbjct: 706 HNDSLNVTLAYPVYA 720
Score = 64.3 bits (155), Expect = 4e-10
Identities = 39/109 (35%), Positives = 56/109 (51%), Gaps = 3/109 (2%)
Query: 323 PSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH 382
P + W G +R + LR DGTFLVR++S QG Y ++ G K +
Sbjct: 617 PHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINK 674
Query: 383 RDGHYGFSEPLT-FCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQ 430
YGF+EP + S+ +L+ HY+H SL Q+N L+ L YPV Q+
Sbjct: 675 TATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 723
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 667 bits (1722), Expect = 0.0
Identities = 323/425 (76%), Positives = 379/425 (89%), Gaps = 7/425 (1%)
Query: 296 EVAPPALPPKPPKAKPAPTVLANGG--SPPSLQDAEWYWGDISREEVNEKLRDTPDGTFL 353
E+ PPALPPKPPK PT +AN G + SLQDAEWYWGDISREEVNEKLRDT DGTFL
Sbjct: 31 EMDPPALPPKPPK----PTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFL 86
Query: 354 VRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQY 413
VRDAS+K+ G+YTLTLRKGGNNKLIK+FHRDG YGFS+PLTF SVV+LINHYR+ESLAQY
Sbjct: 87 VRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQY 146
Query: 414 NAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQE 473
N KLD +LLYPVSKYQQDQ+VKED++EAVG +L Y+ Q+Q+KSREYD+LYEEYTRTSQE
Sbjct: 147 NPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQE 206
Query: 474 LQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIA 533
+QMKRTAIEAFNETIKIFEEQ QTQE+ SKEY+E+F+REGNEKE+QRI+ N ++LKSRI+
Sbjct: 207 IQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRIS 266
Query: 534 EIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINE 593
EI +SR +LE+ L+ QA++ REIDKRMNS+KPDL+QLRK RDQYL+WLTQKG RQKK+NE
Sbjct: 267 EIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNE 326
Query: 594 WLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRG 653
WLG +N TEDQY+L+ED++DLPHH+E+TW VG NR +AE +L GKRDGTFL+RESS++G
Sbjct: 327 WLGNEN-TEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQG 385
Query: 654 CYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLA 713
CYACSVVVDG+ KHCVI +TATG+GFAEPYNLY SLKELVLHYQH SLVQHND+L VTLA
Sbjct: 386 CYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLA 445
Query: 714 HPVRA 718
+PV A
Sbjct: 446 YPVYA 450
Score = 64.3 bits (155), Expect = 4e-10
Identities = 39/109 (35%), Positives = 56/109 (51%), Gaps = 3/109 (2%)
Query: 323 PSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH 382
P + W G +R + LR DGTFLVR++S QG Y ++ G K +
Sbjct: 347 PHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINK 404
Query: 383 RDGHYGFSEPLT-FCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQ 430
YGF+EP + S+ +L+ HY+H SL Q+N L+ L YPV Q+
Sbjct: 405 TATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 453
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 659 bits (1700), Expect = 0.0
Identities = 319/419 (76%), Positives = 374/419 (89%), Gaps = 7/419 (1%)
Query: 302 LPPKPPKAKPAPTVLANGG--SPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASS 359
LPPKPPK PT +AN G + SLQDAEWYWGDISREEVNEKLRDT DGTFLVRDAS+
Sbjct: 7 LPPKPPK----PTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDAST 62
Query: 360 KIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDT 419
K+ G+YTLTLRKGGNNKLIK+FHRDG YGFS+PLTF SVV+LINHYR+ESLAQYN KLD
Sbjct: 63 KMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDV 122
Query: 420 RLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRT 479
+LLYPVSKYQQDQ+VKED++EAVG +L Y+ Q+Q+KSREYD+LYEEYTRTSQE+QMKRT
Sbjct: 123 KLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRT 182
Query: 480 AIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESR 539
AIEAFNETIKIFEEQ QTQE+ SKEY+E+F+REGNEKE+QRI+ N ++LKSRI+EI +SR
Sbjct: 183 AIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIIDSR 242
Query: 540 TKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKN 599
+LE+ L+ QA++ REIDKRMNS+KPDL+QLRK RDQYL+WLTQKG RQKK+NEWLG +N
Sbjct: 243 RRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNEN 302
Query: 600 ETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSV 659
TEDQY+L+ED++DLPHH+E+TW VG NR +AE +L GKRDGTFL+RESS++GCYACSV
Sbjct: 303 -TEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSV 361
Query: 660 VVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRA 718
VVDG+ KHCVI +TATG+GFAEPYNLY SLKELVLHYQH SLVQHND+L VTLA+PV A
Sbjct: 362 VVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA 420
Score = 64.3 bits (155), Expect = 4e-10
Identities = 39/109 (35%), Positives = 56/109 (51%), Gaps = 3/109 (2%)
Query: 323 PSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH 382
P + W G +R + LR DGTFLVR++S QG Y ++ G K +
Sbjct: 317 PHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSK--QGCYACSVVVDGEVKHCVINK 374
Query: 383 RDGHYGFSEPLT-FCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQ 430
YGF+EP + S+ +L+ HY+H SL Q+N L+ L YPV Q+
Sbjct: 375 TATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQR 423
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 650 bits (1678), Expect = 0.0
Identities = 311/429 (72%), Positives = 372/429 (86%), Gaps = 5/429 (1%)
Query: 296 EVAPPALPPKPPKAKPAPTVLANG--GSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFL 353
E+ PPALPPKPPK P + + NG S SLQDAEWYWGDISREEVN+KLRD PDGTFL
Sbjct: 31 EMDPPALPPKPPK--PMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFL 88
Query: 354 VRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQY 413
VRDAS+K+QG+YTLTLRKGGNNKLIK++HRDG YGFS+PLTF SVV+LINHY HESLAQY
Sbjct: 89 VRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQY 148
Query: 414 NAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQE 473
N KLD +L+YPVS+YQQDQ+VKED+++AVG +L+ YH QYQ+KS+EYD+LYEEYTRTSQE
Sbjct: 149 NPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQE 208
Query: 474 LQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIA 533
+QMKRTAIEAFNETIKIFEEQ TQE+ SKEY+ERFRREGNEKE++RI++N ++LKSR+
Sbjct: 209 IQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLG 268
Query: 534 EIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINE 593
EIH+S+ +LEQ L+ QA DNREIDK+MNS+KPDL+QLRKIRDQ+LVWL KG RQK++N
Sbjct: 269 EIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNV 328
Query: 594 WLGIKNETEDQ-YALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQR 652
WLGIKNE D+ Y + E++++LPH++E+TW+V INR QAE++L GK DG FLIRESS++
Sbjct: 329 WLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKK 388
Query: 653 GCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTL 712
GCYACSVV DG+ KHCVIY TA G+GFAEPYNLY SLKELVLHYQ SLVQHND+L V L
Sbjct: 389 GCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRL 448
Query: 713 AHPVRAPGP 721
A+PV A P
Sbjct: 449 AYPVHAQMP 457
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 650 bits (1678), Expect = 0.0
Identities = 311/429 (72%), Positives = 372/429 (86%), Gaps = 5/429 (1%)
Query: 296 EVAPPALPPKPPKAKPAPTVLANG--GSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFL 353
E+ PPALPPKPPK P + + NG S SLQDAEWYWGDISREEVN+KLRD PDGTFL
Sbjct: 31 EMDPPALPPKPPK--PMTSAVPNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFL 88
Query: 354 VRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQY 413
VRDAS+K+QG+YTLTLRKGGNNKLIK++HRDG YGFS+PLTF SVV+LINHY HESLAQY
Sbjct: 89 VRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQY 148
Query: 414 NAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQE 473
N KLD +L+YPVS+YQQDQ+VKED+++AVG +L+ YH QYQ+KS+EYD+LYEEYTRTSQE
Sbjct: 149 NPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQE 208
Query: 474 LQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIA 533
+QMKRTAIEAFNETIKIFEEQ TQE+ SKEY+ERFRREGNEKE++RI++N ++LKSR+
Sbjct: 209 IQMKRTAIEAFNETIKIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLG 268
Query: 534 EIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINE 593
EIH+S+ +LEQ L+ QA DNREIDK+MNS+KPDL+QLRKIRDQ+LVWL KG RQK++N
Sbjct: 269 EIHDSKMRLEQDLKNQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNV 328
Query: 594 WLGIKNETEDQ-YALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQR 652
WLGIKNE D+ Y + E++++LPH++E+TW+V INR QAE++L GK DG FLIRESS++
Sbjct: 329 WLGIKNEDADENYFINEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKK 388
Query: 653 GCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTL 712
GCYACSVV DG+ KHCVIY TA G+GFAEPYNLY SLKELVLHYQ SLVQHND+L V L
Sbjct: 389 GCYACSVVADGEVKHCVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRL 448
Query: 713 AHPVRAPGP 721
A+PV A P
Sbjct: 449 AYPVHAQMP 457
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 65.5 bits (158), Expect = 2e-10
Identities = 40/128 (31%), Positives = 66/128 (51%), Gaps = 8/128 (6%)
Query: 323 PSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH 382
P L W+ G IS +E ++L+ DG FLVR+ S++ G+Y L + G + +V H
Sbjct: 74 PKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRE-SARHPGDYVLCVSFGRDVIHYRVLH 132
Query: 383 RDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAV 442
RDGH E + FC+++D++ HY + A + T+L+ P K+ E+ +
Sbjct: 133 RDGHLTIDEAVFFCNLMDMVEHYSKDKGA-----ICTKLVRPKRKHGTKS--AEEELARA 185
Query: 443 GAQLKVYH 450
G L + H
Sbjct: 186 GWLLNLQH 193
Score = 38.1 bits (87), Expect = 0.029
Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 17/137 (12%)
Query: 594 WLGIKNETEDQYALM-----EDEDDL---PHHEERTWYVGKINRTQAEEMLSGKRDGTFL 645
W +K+ T Q L+ + + L P W+ GKI+ +A + L DG FL
Sbjct: 45 WYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFL 104
Query: 646 IRESSQR-GCYACSVVVDGDTKHC-VIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQ 703
+RES++ G Y V D H V++R G + + +L ++V HY +
Sbjct: 105 VRESARHPGDYVLCVSFGRDVIHYRVLHR--DGHLTIDEAVFFCNLMDMVEHYS-----K 157
Query: 704 HNDALTVTLAHPVRAPG 720
A+ L P R G
Sbjct: 158 DKGAICTKLVRPKRKHG 174
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 65.5 bits (158), Expect = 2e-10
Identities = 40/128 (31%), Positives = 66/128 (51%), Gaps = 8/128 (6%)
Query: 323 PSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH 382
P L W+ G IS +E ++L+ DG FLVR+ S++ G+Y L + G + +V H
Sbjct: 116 PKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRE-SARHPGDYVLCVSFGRDVIHYRVLH 174
Query: 383 RDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAV 442
RDGH E + FC+++D++ HY + A + T+L+ P K+ E+ +
Sbjct: 175 RDGHLTIDEAVFFCNLMDMVEHYSKDKGA-----ICTKLVRPKRKHGTKS--AEEELARA 227
Query: 443 GAQLKVYH 450
G L + H
Sbjct: 228 GWLLNLQH 235
Score = 38.1 bits (87), Expect = 0.029
Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 17/137 (12%)
Query: 594 WLGIKNETEDQYALM-----EDEDDL---PHHEERTWYVGKINRTQAEEMLSGKRDGTFL 645
W +K+ T Q L+ + + L P W+ GKI+ +A + L DG FL
Sbjct: 87 WYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFL 146
Query: 646 IRESSQR-GCYACSVVVDGDTKHC-VIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQ 703
+RES++ G Y V D H V++R G + + +L ++V HY +
Sbjct: 147 VRESARHPGDYVLCVSFGRDVIHYRVLHR--DGHLTIDEAVFFCNLMDMVEHYS-----K 199
Query: 704 HNDALTVTLAHPVRAPG 720
A+ L P R G
Sbjct: 200 DKGAICTKLVRPKRKHG 216
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 65.5 bits (158), Expect = 2e-10
Identities = 40/128 (31%), Positives = 66/128 (51%), Gaps = 8/128 (6%)
Query: 323 PSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH 382
P L W+ G IS +E ++L+ DG FLVR+ S++ G+Y L + G + +V H
Sbjct: 115 PKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRE-SARHPGDYVLCVSFGRDVIHYRVLH 173
Query: 383 RDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAV 442
RDGH E + FC+++D++ HY + A + T+L+ P K+ E+ +
Sbjct: 174 RDGHLTIDEAVFFCNLMDMVEHYSKDKGA-----ICTKLVRPKRKHGTKS--AEEELARA 226
Query: 443 GAQLKVYH 450
G L + H
Sbjct: 227 GWLLNLQH 234
Score = 38.1 bits (87), Expect = 0.029
Identities = 37/137 (27%), Positives = 58/137 (42%), Gaps = 17/137 (12%)
Query: 594 WLGIKNETEDQYALM-----EDEDDL---PHHEERTWYVGKINRTQAEEMLSGKRDGTFL 645
W +K+ T Q L+ + + L P W+ GKI+ +A + L DG FL
Sbjct: 86 WYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFL 145
Query: 646 IRESSQR-GCYACSVVVDGDTKHC-VIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQ 703
+RES++ G Y V D H V++R G + + +L ++V HY +
Sbjct: 146 VRESARHPGDYVLCVSFGRDVIHYRVLHR--DGHLTIDEAVFFCNLMDMVEHYS-----K 198
Query: 704 HNDALTVTLAHPVRAPG 720
A+ L P R G
Sbjct: 199 DKGAICTKLVRPKRKHG 215
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 63.9 bits (154), Expect = 5e-10
Identities = 46/193 (23%), Positives = 85/193 (44%), Gaps = 21/193 (10%)
Query: 245 ALGATFGPLLLRAPPPPSSPPPGGAP-------------DGSEPSPDFPALLVEKLLQEH 291
A GA GP ++ +P P G P G SP + LV+ +
Sbjct: 582 ASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGY 641
Query: 292 LEEQEVAPPALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGT 351
V P + +PP ++P + P W+ G++ R++ + L+ GT
Sbjct: 642 FPSSSVKPCPVDGRPPISRPPSREIDYTAYP-------WFAGNMERQQTDNLLKSHASGT 694
Query: 352 FLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLA 411
+L+R+ ++ + + ++++ K IKV +D +E F S+++L+ +Y+ SL
Sbjct: 695 YLIRERPAEAE-RFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLK 753
Query: 412 QYNAKLDTRLLYP 424
+ +LDT L YP
Sbjct: 754 ESFKQLDTTLKYP 766
Score = 47.0 bits (110), Expect = 6e-05
Identities = 29/98 (29%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
Query: 622 WYVGKINRTQAEEMLSGKRDGTFLIRE-SSQRGCYACSVVVDGDTKHCVIYRTATGFGFA 680
W+ G + R Q + +L GT+LIRE ++ +A S+ + + KH +
Sbjct: 673 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHIT 732
Query: 681 EPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRA 718
E + SL ELV +YQ SL + L TL +P ++
Sbjct: 733 EA-KKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKS 769
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 63.9 bits (154), Expect = 5e-10
Identities = 46/193 (23%), Positives = 85/193 (44%), Gaps = 21/193 (10%)
Query: 245 ALGATFGPLLLRAPPPPSSPPPGGAP-------------DGSEPSPDFPALLVEKLLQEH 291
A GA GP ++ +P P G P G SP + LV+ +
Sbjct: 572 ASGAGPGPKMVAMQNYHGNPAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGY 631
Query: 292 LEEQEVAPPALPPKPPKAKPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGT 351
V P + +PP ++P + P W+ G++ R++ + L+ GT
Sbjct: 632 FPSSSVKPCPVDGRPPISRPPSREIDYTAYP-------WFAGNMERQQTDNLLKSHASGT 684
Query: 352 FLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLA 411
+L+R+ ++ + + ++++ K IKV +D +E F S+++L+ +Y+ SL
Sbjct: 685 YLIRERPAEAE-RFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLK 743
Query: 412 QYNAKLDTRLLYP 424
+ +LDT L YP
Sbjct: 744 ESFKQLDTTLKYP 756
Score = 47.0 bits (110), Expect = 6e-05
Identities = 29/98 (29%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
Query: 622 WYVGKINRTQAEEMLSGKRDGTFLIRE-SSQRGCYACSVVVDGDTKHCVIYRTATGFGFA 680
W+ G + R Q + +L GT+LIRE ++ +A S+ + + KH +
Sbjct: 663 WFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIHIT 722
Query: 681 EPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRA 718
E + SL ELV +YQ SL + L TL +P ++
Sbjct: 723 EA-KKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKS 759
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/115 (32%), Positives = 59/115 (51%), Gaps = 5/115 (4%)
Query: 310 KPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTL 369
KP P V P WY G + R + +L + + T+LVR + K GEY +++
Sbjct: 96 KPCPCV----PKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRT-KESGEYAISI 150
Query: 370 RKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYP 424
+ K IK+ RDG + +E F S+++L+ +Y+H SL + LDT L +P
Sbjct: 151 KYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 205
Score = 56.2 bits (134), Expect = 1e-07
Identities = 35/99 (35%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 622 WYVGKINRTQAEEMLSGKRDGTFLIRE-SSQRGCYACSVVVDGDTKHCVIYRTATGFGFA 680
WY G + R QAE L + + T+L+R + + G YA S+ + + KH I T GF
Sbjct: 112 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKIL-TRDGFFHI 170
Query: 681 EPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAP 719
+ SL ELV +Y+H SL + L TL P + P
Sbjct: 171 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEP 209
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/115 (32%), Positives = 59/115 (51%), Gaps = 5/115 (4%)
Query: 310 KPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTL 369
KP P V P WY G + R + +L + + T+LVR + K GEY +++
Sbjct: 656 KPCPCV----PKPVDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRT-KESGEYAISI 710
Query: 370 RKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYP 424
+ K IK+ RDG + +E F S+++L+ +Y+H SL + LDT L +P
Sbjct: 711 KYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFP 765
Score = 56.2 bits (134), Expect = 1e-07
Identities = 35/99 (35%), Positives = 50/99 (50%), Gaps = 2/99 (2%)
Query: 622 WYVGKINRTQAEEMLSGKRDGTFLIRE-SSQRGCYACSVVVDGDTKHCVIYRTATGFGFA 680
WY G + R QAE L + + T+L+R + + G YA S+ + + KH I T GF
Sbjct: 672 WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKIL-TRDGFFHI 730
Query: 681 EPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAP 719
+ SL ELV +Y+H SL + L TL P + P
Sbjct: 731 AENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEP 769
>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
Length = 535
Score = 58.2 bits (139), Expect = 3e-08
Identities = 40/114 (35%), Positives = 55/114 (48%), Gaps = 14/114 (12%)
Query: 330 WYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGF 389
WYWG I+R E KL + PDG+FLVRD SS + +L+ R G ++ H +G + F
Sbjct: 384 WYWGPITRWEAEGKLANVPDGSFLVRD-SSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF 442
Query: 390 SEPLT---FCSVVDLINHYRHE----------SLAQYNAKLDTRLLYPVSKYQQ 430
E S+VDLI H + S +A RL PVS++ Q
Sbjct: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQ 496
Score = 43.5 bits (101), Expect = 7e-04
Identities = 34/117 (29%), Positives = 55/117 (47%), Gaps = 7/117 (5%)
Query: 612 DDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESS-QRGCYACSVVVDGDTKHCVI 670
++L ++ WY G I R +AE L+ DG+FL+R+SS R + S G T H I
Sbjct: 374 EELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRI 433
Query: 671 YRTATGFGFAEPYNLYG--SLKELVLH----YQHASLVQHNDALTVTLAHPVRAPGP 721
+ F F E ++ G S+ +L+ H ++ + L + +PVR P
Sbjct: 434 EHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNP 490
>gi|91208437 GEM interacting protein [Homo sapiens]
Length = 970
Score = 58.2 bits (139), Expect = 3e-08
Identities = 73/259 (28%), Positives = 98/259 (37%), Gaps = 36/259 (13%)
Query: 92 GPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELP 151
G R LPAR P G+ LP F P+ P ++ K IE LD + YR
Sbjct: 538 GHRRLPAR----TPLFGVDFLQLPRDF--PEEVPFVVTKCTAEIEHRALDVQGIYRVSGS 591
Query: 152 APRTDW---------SLSDVDQWDTAALADGIKSFLLALPAPLVT---PEASAEARRALR 199
R + +L ++ ++ +K FL L P++ +A + L
Sbjct: 592 RVRVERLCQAFENGRALVELSGNSPHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLH 651
Query: 200 EAAG--PVGPALEPPTLPLHRAL----------TLRFLLQHLGRVARRAPALGPAVRALG 247
G P P+ P + + L TLR L+ HL RVA R + LG
Sbjct: 652 ADPGDDPGTPSPSPEVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLG 711
Query: 248 ATFGPLLLRAPPPPSSPPPGGA-PDGSEPSPDFPALLVEKLL--QEHLEEQEVAPPALPP 304
FGP LLR PP P A P A LVE L+ E + + P A P
Sbjct: 712 IVFGPTLLR---PPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQIFGMDELPQATEP 768
Query: 305 KPPKAKPAPTVLANGGSPP 323
P + PAP L PP
Sbjct: 769 PPQDSSPAPGPLTTSSQPP 787
Score = 32.0 bits (71), Expect = 2.1
Identities = 34/119 (28%), Positives = 44/119 (36%), Gaps = 19/119 (15%)
Query: 198 LREAAGPVGPALEPPTLPL---HRALTLRFLLQHLGRVA---RRAPALGPAVRALGATFG 251
LR GP + P T L H+A + FL+ H ++ A P + G
Sbjct: 719 LRPPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPG 778
Query: 252 PLLLRAPPPPSSPPPGGAPD--GSEPSPDFPALLVEKLLQEH--LEEQEVAPPALPPKP 306
PL + PPP P P S+P PD Q H LE+ A P P P
Sbjct: 779 PLTTSSQPPPPHLDPDSQPPVLASDPGPD---------PQHHSTLEQHPTATPTEIPTP 828
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 56.2 bits (134), Expect = 1e-07
Identities = 49/177 (27%), Positives = 76/177 (42%), Gaps = 20/177 (11%)
Query: 320 GSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIK 379
G P L WY G + R L + DGTFLVR K E+ ++++ K IK
Sbjct: 661 GPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRV-KDAAEFAISIKYNVEVKHIK 719
Query: 380 VFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSV 439
+ +G Y +E F + +L+ Y+ SL LDT L +P + ++ I S
Sbjct: 720 IMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRTI----SR 775
Query: 440 EAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQ 496
AVG+ +Y ++ Y+ R EL +K + IKI ++GQ
Sbjct: 776 PAVGS------TKYFGTAK---ARYDFCARDRSELSLKE------GDIIKILNKKGQ 817
Score = 52.4 bits (124), Expect = 1e-06
Identities = 34/99 (34%), Positives = 48/99 (48%), Gaps = 2/99 (2%)
Query: 622 WYVGKINRTQAEEMLSGKRDGTFLIRESSQRGC-YACSVVVDGDTKHCVIYRTATGFGFA 680
WY G + R AE +L+ + DGTFL+R+ + +A S+ + + KH I TA G
Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKI-MTAEGLYRI 729
Query: 681 EPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAP 719
+ L ELV YQ SL +L TL P + P
Sbjct: 730 TEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEP 768
>gi|195976771 cytokine-inducible SH2-containing protein isoform 1
[Homo sapiens]
Length = 275
Score = 55.5 bits (132), Expect = 2e-07
Identities = 42/140 (30%), Positives = 66/140 (47%), Gaps = 10/140 (7%)
Query: 275 PSPDFPALLVEKL-LQEHLEEQEVAPPALPPKPPKA-KPAPTVLANGGSPPSLQDAEWYW 332
PS + P +++ L LEE PA PK P +L + L+++ WYW
Sbjct: 42 PSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYW 101
Query: 333 GDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYG---- 388
G I+ E + L+ P+GTFLVRD S+ +TL+++ +++ + D +
Sbjct: 102 GSITASEARQHLQKMPEGTFLVRD-STHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSN 160
Query: 389 -FSEP--LTFCSVVDLINHY 405
S P L F VV L+ HY
Sbjct: 161 CLSRPRILAFPDVVSLVQHY 180
Score = 37.4 bits (85), Expect = 0.050
Identities = 39/140 (27%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
Query: 596 GIKNETEDQYALMEDEDDL-------PHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRE 648
G +TE + +++ E+DL + E WY G I ++A + L +GTFL+R+
Sbjct: 66 GTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRD 125
Query: 649 SSQRG-CYACSV-VVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHND 706
S+ + SV G T + Y ++ F N S ++ SLVQH
Sbjct: 126 STHPSYLFTLSVKTTRGPTNVRIEYADSS---FRLDSNCL-SRPRILAFPDVVSLVQHYV 181
Query: 707 ALTVTLAHPVRAPGPGPPPA 726
A + T +P P P PA
Sbjct: 182 A-SCTADTRSDSPDPAPTPA 200
>gi|21614507 cytokine-inducible SH2-containing protein isoform 2
[Homo sapiens]
Length = 258
Score = 55.5 bits (132), Expect = 2e-07
Identities = 42/140 (30%), Positives = 66/140 (47%), Gaps = 10/140 (7%)
Query: 275 PSPDFPALLVEKL-LQEHLEEQEVAPPALPPKPPKA-KPAPTVLANGGSPPSLQDAEWYW 332
PS + P +++ L LEE PA PK P +L + L+++ WYW
Sbjct: 25 PSLELPKPVMQPLPAGAFLEEVAEGTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYW 84
Query: 333 GDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYG---- 388
G I+ E + L+ P+GTFLVRD S+ +TL+++ +++ + D +
Sbjct: 85 GSITASEARQHLQKMPEGTFLVRD-STHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSN 143
Query: 389 -FSEP--LTFCSVVDLINHY 405
S P L F VV L+ HY
Sbjct: 144 CLSRPRILAFPDVVSLVQHY 163
Score = 37.4 bits (85), Expect = 0.050
Identities = 39/140 (27%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
Query: 596 GIKNETEDQYALMEDEDDL-------PHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRE 648
G +TE + +++ E+DL + E WY G I ++A + L +GTFL+R+
Sbjct: 49 GTPAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRD 108
Query: 649 SSQRG-CYACSV-VVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHND 706
S+ + SV G T + Y ++ F N S ++ SLVQH
Sbjct: 109 STHPSYLFTLSVKTTRGPTNVRIEYADSS---FRLDSNCL-SRPRILAFPDVVSLVQHYV 164
Query: 707 ALTVTLAHPVRAPGPGPPPA 726
A + T +P P P PA
Sbjct: 165 A-SCTADTRSDSPDPAPTPA 183
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/161 (26%), Positives = 78/161 (48%), Gaps = 18/161 (11%)
Query: 565 PDLMQLRKIRDQYLVW-LTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWY 623
PD Q+RK++ + +++ +N + + + E+E++L ++ W+
Sbjct: 241 PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYD---WF 297
Query: 624 VGKINRTQAEEMLSGK-RDGTFLIRESSQRGCYACSVV------VDGDTKHCVIYRTATG 676
G I+R+Q+E++L K ++G F++R SSQ G Y S+ G KH ++ A
Sbjct: 298 AGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAEN 357
Query: 677 FGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVT-LAHPV 716
+ + S+ +L+ HY QHN A +T L HPV
Sbjct: 358 KLYLAENYCFDSIPKLI-HYH-----QHNSAGMITRLRHPV 392
Score = 47.0 bits (110), Expect = 6e-05
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 15/111 (13%)
Query: 324 SLQDAEWYWGDISREEVNEKLRDT-PDGTFLVRDASSKIQGEYTLTL-RKGGNNKLIKVF 381
+L D +W+ G+ISR + + LR +G F+VR++S G YT++L K N+K V
Sbjct: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQ--VGMYTVSLFSKAVNDKKGTVK 347
Query: 382 HRDGHYG------FSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVS 426
H H +E F S+ LI++++H S A + TRL +PVS
Sbjct: 348 HYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNS-----AGMITRLRHPVS 393
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 54.7 bits (130), Expect = 3e-07
Identities = 43/161 (26%), Positives = 78/161 (48%), Gaps = 18/161 (11%)
Query: 565 PDLMQLRKIRDQYLVW-LTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWY 623
PD Q+RK++ + +++ +N + + + E+E++L ++ W+
Sbjct: 241 PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYD---WF 297
Query: 624 VGKINRTQAEEMLSGK-RDGTFLIRESSQRGCYACSVV------VDGDTKHCVIYRTATG 676
G I+R+Q+E++L K ++G F++R SSQ G Y S+ G KH ++ A
Sbjct: 298 AGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAEN 357
Query: 677 FGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVT-LAHPV 716
+ + S+ +L+ HY QHN A +T L HPV
Sbjct: 358 KLYLAENYCFDSIPKLI-HYH-----QHNSAGMITRLRHPV 392
Score = 47.0 bits (110), Expect = 6e-05
Identities = 38/111 (34%), Positives = 59/111 (53%), Gaps = 15/111 (13%)
Query: 324 SLQDAEWYWGDISREEVNEKLRDT-PDGTFLVRDASSKIQGEYTLTL-RKGGNNKLIKVF 381
+L D +W+ G+ISR + + LR +G F+VR++S G YT++L K N+K V
Sbjct: 290 NLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQ--VGMYTVSLFSKAVNDKKGTVK 347
Query: 382 HRDGHYG------FSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVS 426
H H +E F S+ LI++++H S A + TRL +PVS
Sbjct: 348 HYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNS-----AGMITRLRHPVS 393
>gi|158631203 dual adaptor of phosphotyrosine and
3-phosphoinositides [Homo sapiens]
Length = 280
Score = 54.7 bits (130), Expect = 3e-07
Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 593 EWLGIKNETEDQYALMEDED-DLPHHEERTWYVGKINRTQAEEML-SGKRDGTFLIRESS 650
E L K T+D L D + ++ WY G + R AE +L S DG++L+R+S+
Sbjct: 5 ELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSN 64
Query: 651 QR-GCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALT 709
+ G Y+ SV KH + TG+ F +N + SLK+ V H+ + L+
Sbjct: 65 ETTGLYSLSVRAKDSVKH--FHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTL 122
Query: 710 VTLAHP 715
+ L HP
Sbjct: 123 MVLKHP 128
Score = 42.0 bits (97), Expect = 0.002
Identities = 31/97 (31%), Positives = 53/97 (54%), Gaps = 13/97 (13%)
Query: 320 GSPPSLQDAEWYWGDISREEVNEKLRDTP-DGTFLVRDASSKIQGEYTLTLRKGGNNKLI 378
G LQD WY G+++R L DG++L+RD S++ G Y+L++R + +
Sbjct: 25 GEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRD-SNETTGLYSLSVRAKDS---V 80
Query: 379 KVFHRD--GH---YGFSEPLTFCSVVDLINHYRHESL 410
K FH + G+ +GF+E F S+ D + H+ ++ L
Sbjct: 81 KHFHVEYTGYSFKFGFNE---FSSLKDFVKHFANQPL 114
>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
Length = 198
Score = 54.3 bits (129), Expect = 4e-07
Identities = 32/105 (30%), Positives = 54/105 (51%), Gaps = 12/105 (11%)
Query: 310 KPAPTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTL 369
+P+P + L WYWG ++ E EKL++ P+GTFL+RD+S +Y LT+
Sbjct: 28 EPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSS---HSDYLLTI 84
Query: 370 --RKGGNNKLIKVFHRDGHYGF-------SEPLTFCSVVDLINHY 405
+ +++ ++DG + S+ F SVV LI++Y
Sbjct: 85 SVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY 129
Score = 32.0 bits (71), Expect = 2.1
Identities = 14/29 (48%), Positives = 19/29 (65%)
Query: 622 WYVGKINRTQAEEMLSGKRDGTFLIRESS 650
WY G + +A+E L +GTFLIR+SS
Sbjct: 48 WYWGSMTVNEAKEKLKEAPEGTFLIRDSS 76
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 53.9 bits (128), Expect = 5e-07
Identities = 39/106 (36%), Positives = 53/106 (50%), Gaps = 11/106 (10%)
Query: 622 WYVGKINRTQAEEML--SGKRDGTFLIRES-SQRGCYACSVVVDGDTKHCVIYRTATGFG 678
W+ G I R+ AE+ L S + G+FLIRES SQ+G ++ SV+ KH I R G
Sbjct: 116 WFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGF 175
Query: 679 FAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHP---VRAPGP 721
F ++ +L E V HY S D L V L P ++ P P
Sbjct: 176 FLTRRRIFSTLNEFVSHYTKTS-----DGLCVKLGKPCLKIQVPAP 216
Score = 40.0 bits (92), Expect = 0.008
Identities = 24/89 (26%), Positives = 49/89 (55%), Gaps = 4/89 (4%)
Query: 324 SLQDAEWYWGDISREEVNEKL--RDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVF 381
SLQ W++G I R + ++L + G+FL+R++ S+ +GE++L++ G K ++
Sbjct: 110 SLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQ-KGEFSLSVLDGAVVKHYRIK 168
Query: 382 HRD-GHYGFSEPLTFCSVVDLINHYRHES 409
D G + + F ++ + ++HY S
Sbjct: 169 RLDEGGFFLTRRRIFSTLNEFVSHYTKTS 197
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 53.9 bits (128), Expect = 5e-07
Identities = 50/210 (23%), Positives = 99/210 (47%), Gaps = 24/210 (11%)
Query: 430 QDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIK 489
Q+++ V+ +G + Y QY++ + D++ E ++S + Q + +++ E +K
Sbjct: 1425 QEKVKTITQVKKIGRR---YKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQE-LK 1480
Query: 490 IFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLK-----SRIAEIHESRTKLEQ 544
Q +T+ K + +E ++ +EKE + L + ++ SR+ + + RT E+
Sbjct: 1481 ETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEE 1540
Query: 545 QLRAQASDNRE-IDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETED 603
QLR Q ++ E K + + K + L ++DQ K NE L +N D
Sbjct: 1541 QLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQL-----------TKENEELKQRNGALD 1589
Query: 604 QYALMEDEDDLPHHEERTWYVGKINRTQAE 633
Q +DE D+ ++ Y G+I+R + E
Sbjct: 1590 Q---QKDELDVRITALKSQYEGRISRLERE 1616
Score = 35.0 bits (79), Expect = 0.25
Identities = 47/235 (20%), Positives = 100/235 (42%), Gaps = 34/235 (14%)
Query: 405 YRHESLAQYNAKLDTRLLYPVSKYQQDQIVKED--------SVEAVGAQLKVYHQQYQDK 456
++ ES QY +++ RL + Q+++V E +E + QLK ++ ++
Sbjct: 46 FKVESEQQY-FEIEKRL-----SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKEL 99
Query: 457 SREYDQ---LYEEYTRTSQELQMKRTAIEAFNETIK-----IFEEQGQTQEKCSKEYLER 508
D+ + ++TRT +EL+ ++ + NE + + E+ + EK + +
Sbjct: 100 EIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTK 159
Query: 509 FRREGNEKEMQ----RILLNSERLKSRIAEIHESRTKLEQQLRAQASD----NREIDKRM 560
+ E+Q + +RL+ +H T L +L+ + + RE +
Sbjct: 160 GELQLKLDELQASDVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEI 219
Query: 561 NSLKPDL----MQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDE 611
LK +L ++ ++ +Q T QK + + L E ++Q A ME++
Sbjct: 220 LELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEK 274
Score = 35.0 bits (79), Expect = 0.25
Identities = 46/218 (21%), Positives = 87/218 (39%), Gaps = 46/218 (21%)
Query: 413 YNAKLDTRLLYPVSKYQQ-------DQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYE 465
YNA ++T+ + K + D+IVKE VEA LK ++Y+ + L
Sbjct: 399 YNAYVETQDQLLLEKLENKRINKYLDEIVKE--VEAKAPILKRQREEYERAQKAVASLSV 456
Query: 466 EYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFR--------REGNE-- 515
+ + +E+Q + + N+ + E + E K+ ++ R GN
Sbjct: 457 KLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVI 516
Query: 516 ------------------------KEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQAS 551
+ ++ + ++RL + E+ E+R + EQ+ +S
Sbjct: 517 RDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQE--TTSS 574
Query: 552 DNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQK 589
E+ ++ S +L QLRK R Q+ + L RQ+
Sbjct: 575 KITELQLKLESALTELEQLRKSR-QHQMQLVDSIVRQR 611
>gi|42475970 synapse defective 1, Rho GTPase, homolog 1 [Homo
sapiens]
Length = 735
Score = 53.9 bits (128), Expect = 5e-07
Identities = 73/265 (27%), Positives = 97/265 (36%), Gaps = 41/265 (15%)
Query: 108 GLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDT 167
GL LP L E+ PP P ++ K V IER GL YR + L D + D+
Sbjct: 397 GLPLPLLVERERPPGQVPLIIQKCVGQIERRGLRVVGLYR-LCGSAAVKKELRDAFERDS 455
Query: 168 AA-------------LADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPT- 213
AA + +K +L LP PL+T + + EA P PPT
Sbjct: 456 AAVCLSEDLYPDINVITGILKDYLRELPTPLIT----QPLYKVVLEAMARDPPNRVPPTT 511
Query: 214 ---------LPLHRALTLRFLLQHLGRVARRAPALGPAVRALGATFGPLLLRAPPPPSSP 264
LP TL LL HL V+ + L FGP+LL A P+ P
Sbjct: 512 EGTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRP 571
Query: 265 PPGGAPDGSEPSPDFP--ALLVEKLLQE------HLEEQEVAPPALPPKPPK-----AKP 311
+ G + DF ++ LLQ + +VAP P + P A P
Sbjct: 572 RARSSGPGLASAVDFKHHIEVLHYLLQSWPDPRLPRQSPDVAPYLRPKRQPPLHLPLADP 631
Query: 312 APTVLANGGSPPSLQDAEWYWGDIS 336
G P + Y GD S
Sbjct: 632 EVVTRPRGRGGPESPPSNRYAGDWS 656
Score = 30.8 bits (68), Expect = 4.6
Identities = 25/82 (30%), Positives = 31/82 (37%), Gaps = 20/82 (24%)
Query: 238 ALGPAVRALGATFG-----PLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHL 292
+LGP V G G P+ P PP+ PPG P +E E L
Sbjct: 95 SLGPGVPGTGEPAGEIWYNPIPEEDPRPPAPEPPGPQPGSAE--------------SEGL 140
Query: 293 EEQEVAPPALPPKPPKAK-PAP 313
Q AP + P K + K P P
Sbjct: 141 APQGAAPASPPTKASRTKSPGP 162
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 53.5 bits (127), Expect = 7e-07
Identities = 76/262 (29%), Positives = 91/262 (34%), Gaps = 60/262 (22%)
Query: 84 ARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPP--DVAPPL--LVKLVEAIERTG 139
AR GP RG PA P P+ L P Q +PP D AP L L A
Sbjct: 253 ARSGPSARGTPRAPAHPSQPKPKGLQALR--PPQVTPPRKDAAPALGPLSSSPLATPSPS 310
Query: 140 LDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALR 199
+S P LPA SL+ LA P PL P SA
Sbjct: 311 AALQSQAPPTLPATPHSSSLT----------------CQLATPLPLAPPSPSAP------ 348
Query: 200 EAAGPVGPALE----PPTLPLHRALTLRFLLQHLGRVARRA-----------PALGPAVR 244
P+L+ PP P +A T LG +A P P +
Sbjct: 349 -------PSLQTLPSPPATPPSQATT------SLGSPTLQATHSFLPSPPLSPLATPPPQ 395
Query: 245 ALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPP 304
A A P L P PP+SPP + PSP P L LLQ P P
Sbjct: 396 APPALALPPLQAPPSPPASPPLSPL---ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 452
Query: 305 KPPKAKP-APTVLANGGSPPSL 325
PP + P +P+ +PPSL
Sbjct: 453 SPPASPPVSPSATPPSQAPPSL 474
Score = 48.5 bits (114), Expect = 2e-05
Identities = 79/275 (28%), Positives = 98/275 (35%), Gaps = 57/275 (20%)
Query: 78 LGPVA---LARPGP----RPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDV-APPLLV 129
LGP++ LA P P + + P LPA P + L P LP +PP APP L
Sbjct: 296 LGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATP-LP--LAPPSPSAPPSLQ 352
Query: 130 KLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALP-APLVTP 188
L P P + SL + SFL + P +PL TP
Sbjct: 353 TLPSP-------------PATPPSQATTSLG-------SPTLQATHSFLPSPPLSPLATP 392
Query: 189 EASAEARRALREAAGPVGPALEPPTLPLH-------RALTLRFLLQHLGRV------ARR 235
A AL P P PP PL AL + L A
Sbjct: 393 PPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPF 452
Query: 236 APALGPAVR--ALGATFGPLLLRAPP------PPSSPPPGGAPDGSEPSPDFPALLVEKL 287
+P P V A + P L APP PP+SPP + P P P L
Sbjct: 453 SPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPP---MSPSATPPPQAPPPLAAPP 509
Query: 288 LQEHLEEQEVAPPALPPKPPKAKPAPTVLANGGSP 322
LQ + APPAL P +A P+P G +P
Sbjct: 510 LQ-LAKPPPQAPPALATPPLQALPSPPASFPGQAP 543
Score = 40.0 bits (92), Expect = 0.008
Identities = 58/243 (23%), Positives = 78/243 (32%), Gaps = 37/243 (15%)
Query: 88 PRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYR 147
P + P L A P P P + P P PP PPL ++ + +
Sbjct: 466 PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT 525
Query: 148 PELPA-PRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVG 206
P L A P S + +A + LA P P P +A + + P
Sbjct: 526 PPLQALPSPPASFPGQAPFSPSA---SLPMSPLATPPPQAPPVLAAPLLQV--PPSPPAS 580
Query: 207 PALEPPTLPLHRALTLRFLLQHLGRVARRAPALGPAVRALGATFGPLLLRAPPPPSSPPP 266
P L+ P RR P GP + GP L A P PPP
Sbjct: 581 PTLQAP---------------------RRPPTPGPDT----SVSGPRLTLALAPGPPPPP 615
Query: 267 GGAPDGSEPSPDFPALLVEKL-LQEHLEEQEVAPP--ALPPKPPKAKPA---PTVLANGG 320
+P + PD E L + P A PP A+ A P + G
Sbjct: 616 SRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGP 675
Query: 321 SPP 323
+PP
Sbjct: 676 APP 678
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 53.1 bits (126), Expect = 9e-07
Identities = 34/99 (34%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 618 EERTWYVGKINRTQAEEMLSGKRDGTFLIRES-SQRGCYACSVVVDGDTKHCVIYRTATG 676
E+ +WY G ++R+ AE +LS +G+FL+RES S G + S+ +G H I TA G
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 213
Query: 677 FGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHP 715
+ + + +L ELV H+ + D L TL +P
Sbjct: 214 KVYVTAESRFSTLAELVHHHSTVA-----DGLVTTLHYP 247
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 17/110 (15%)
Query: 324 SLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH- 382
SL+ WY G +SR L +G+FLVR++ S G+ +++LR G +V+H
Sbjct: 152 SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESS-PGQLSISLRYEG-----RVYHY 205
Query: 383 -----RDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSK 427
DG + F ++ +L++H H ++A L T L YP K
Sbjct: 206 RINTTADGKVYVTAESRFSTLAELVHH--HSTVAD---GLVTTLHYPAPK 250
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 53.1 bits (126), Expect = 9e-07
Identities = 34/99 (34%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 618 EERTWYVGKINRTQAEEMLSGKRDGTFLIRES-SQRGCYACSVVVDGDTKHCVIYRTATG 676
E+ +WY G ++R+ AE +LS +G+FL+RES S G + S+ +G H I TA G
Sbjct: 169 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 228
Query: 677 FGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHP 715
+ + + +L ELV H+ + D L TL +P
Sbjct: 229 KVYVTAESRFSTLAELVHHHSTVA-----DGLVTTLHYP 262
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 17/110 (15%)
Query: 324 SLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH- 382
SL+ WY G +SR L +G+FLVR++ S G+ +++LR G +V+H
Sbjct: 167 SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESS-PGQLSISLRYEG-----RVYHY 220
Query: 383 -----RDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSK 427
DG + F ++ +L++H H ++A L T L YP K
Sbjct: 221 RINTTADGKVYVTAESRFSTLAELVHH--HSTVAD---GLVTTLHYPAPK 265
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 53.1 bits (126), Expect = 9e-07
Identities = 34/99 (34%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 618 EERTWYVGKINRTQAEEMLSGKRDGTFLIRES-SQRGCYACSVVVDGDTKHCVIYRTATG 676
E+ +WY G ++R+ AE +LS +G+FL+RES S G + S+ +G H I TA G
Sbjct: 148 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 207
Query: 677 FGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHP 715
+ + + +L ELV H+ + D L TL +P
Sbjct: 208 KVYVTAESRFSTLAELVHHHSTVA-----DGLVTTLHYP 241
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 17/110 (15%)
Query: 324 SLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH- 382
SL+ WY G +SR L +G+FLVR++ S G+ +++LR G +V+H
Sbjct: 146 SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESS-PGQLSISLRYEG-----RVYHY 199
Query: 383 -----RDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSK 427
DG + F ++ +L++H H ++A L T L YP K
Sbjct: 200 RINTTADGKVYVTAESRFSTLAELVHH--HSTVAD---GLVTTLHYPAPK 244
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 53.1 bits (126), Expect = 9e-07
Identities = 34/99 (34%), Positives = 53/99 (53%), Gaps = 6/99 (6%)
Query: 618 EERTWYVGKINRTQAEEMLSGKRDGTFLIRES-SQRGCYACSVVVDGDTKHCVIYRTATG 676
E+ +WY G ++R+ AE +LS +G+FL+RES S G + S+ +G H I TA G
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADG 213
Query: 677 FGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHP 715
+ + + +L ELV H+ + D L TL +P
Sbjct: 214 KVYVTAESRFSTLAELVHHHSTVA-----DGLVTTLHYP 247
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 17/110 (15%)
Query: 324 SLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFH- 382
SL+ WY G +SR L +G+FLVR++ S G+ +++LR G +V+H
Sbjct: 152 SLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESS-PGQLSISLRYEG-----RVYHY 205
Query: 383 -----RDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSK 427
DG + F ++ +L++H H ++A L T L YP K
Sbjct: 206 RINTTADGKVYVTAESRFSTLAELVHH--HSTVAD---GLVTTLHYPAPK 250
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,782,810
Number of Sequences: 37866
Number of extensions: 2113439
Number of successful extensions: 25521
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 254
Number of HSP's successfully gapped in prelim test: 1247
Number of HSP's that attempted gapping in prelim test: 16404
Number of HSP's gapped (non-prelim): 7345
length of query: 728
length of database: 18,247,518
effective HSP length: 110
effective length of query: 618
effective length of database: 14,082,258
effective search space: 8702835444
effective search space used: 8702835444
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.