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Search of human proteins with 4759226
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4759226 transforming growth factor, beta receptor I isoform
1 precursor [Homo sapiens]
(503 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4759226 transforming growth factor, beta receptor I isoform 1... 1025 0.0
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 692 0.0
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 659 0.0
gi|195963412 transforming growth factor, beta receptor I isoform... 637 0.0
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 624 e-179
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 623 e-178
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 542 e-154
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 537 e-152
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 494 e-140
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 487 e-137
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 454 e-128
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 454 e-128
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 424 e-119
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 424 e-119
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 395 e-110
gi|67782324 transforming growth factor, beta receptor II isoform... 234 1e-61
gi|67782326 transforming growth factor, beta receptor II isoform... 234 1e-61
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 232 5e-61
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 221 1e-57
gi|15451916 bone morphogenetic protein receptor type II precurso... 196 3e-50
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 167 2e-41
gi|187475373 c-src tyrosine kinase [Homo sapiens] 95 1e-19
gi|4758078 c-src tyrosine kinase [Homo sapiens] 95 1e-19
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 95 2e-19
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 95 2e-19
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 85 1e-16
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 85 1e-16
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 85 1e-16
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 85 1e-16
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 84 2e-16
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 1025 bits (2651), Expect = 0.0
Identities = 503/503 (100%), Positives = 503/503 (100%)
Query: 1 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE 60
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
Sbjct: 1 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE 60
Query: 61 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG 120
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
Sbjct: 61 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG 120
Query: 121 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL 180
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
Sbjct: 121 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL 180
Query: 181 IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER 240
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
Sbjct: 181 IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER 240
Query: 241 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE 300
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
Sbjct: 241 SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE 300
Query: 301 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS 360
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
Sbjct: 301 GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS 360
Query: 361 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI 420
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
Sbjct: 361 ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI 420
Query: 421 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA 480
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
Sbjct: 421 HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA 480
Query: 481 ARLTALRIKKTLSQLSQQEGIKM 503
ARLTALRIKKTLSQLSQQEGIKM
Sbjct: 481 ARLTALRIKKTLSQLSQQEGIKM 503
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 692 bits (1787), Expect = 0.0
Identities = 351/510 (68%), Positives = 405/510 (79%), Gaps = 15/510 (2%)
Query: 2 EAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTET 61
E+A A+ L++L+LA + + G AL C C C + N+TC TDG C VS+
Sbjct: 3 ESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIFNL 59
Query: 62 TDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL--PTTVKSSP 119
H CI +++L+P +PF C S + T+CC D+CN+I+L P+ P
Sbjct: 60 DGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLKEP 116
Query: 120 G----LGPVELAAVIAGPV--CFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISE 173
GPVEL +IAGPV F+ I ++ +V H R + + + EDPS + +S+
Sbjct: 117 EHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEM-CLSK 175
Query: 174 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKI 233
TL+DL+YD++TSGSGSGLPL VQRT+ARTIVLQE IGKGRFGEVWRG+WRG +VAVKI
Sbjct: 176 DKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKI 235
Query: 234 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 293
FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN
Sbjct: 236 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 295
Query: 294 RYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLG 353
RYTVT+EGMIKLALS ASGLAHLHMEIVGTQGKP IAHRDLKSKNILVKKNG C IADLG
Sbjct: 296 RYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLG 355
Query: 354 LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR 413
LAVRHD+ TDTIDIAPN RVGTKRYMAPEVLD++INMKHF+SFK ADIYA+GLV+WEIAR
Sbjct: 356 LAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIAR 415
Query: 414 RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRE 473
RC+ GG+HE+YQLPYYDLVPSDPS+EEMRKVVC+QKLRPNIPN WQS EALRVM K+MRE
Sbjct: 416 RCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRE 475
Query: 474 CWYANGAARLTALRIKKTLSQLSQQEGIKM 503
CWYANGAARLTALRIKKTLSQLS QE +K+
Sbjct: 476 CWYANGAARLTALRIKKTLSQLSVQEDVKI 505
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 659 bits (1700), Expect = 0.0
Identities = 342/504 (67%), Positives = 391/504 (77%), Gaps = 19/504 (3%)
Query: 3 AAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETT 62
A +A R LLLL AAAA L PG L+C C LC NFTC T+G C+ SV T
Sbjct: 4 ALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVMLTN 54
Query: 63 DKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKI--ELPTTVKSSPG 120
K C++ +P V SS +VT T CC D CN I LPT ++P
Sbjct: 55 GKEQVIKSCVS----LPELNAQVFCHSS--NNVTKTECCFTDFCNNITLHLPTASPNAPK 108
Query: 121 LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRV--PNEEDPSLDRPFISEGTTLK 178
LGP+ELA +I PVC + I+ ML V+ C R + + PN E+P + ++ G TLK
Sbjct: 109 LGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLK 168
Query: 179 DLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSRE 238
DLIYD+T SGSGSGLPLLVQRTIARTIVLQE +GKGRFGEVW G+W GE+VAVKIFSSR+
Sbjct: 169 DLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRD 228
Query: 239 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVT 298
ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VT
Sbjct: 229 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVT 288
Query: 299 VEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRH 358
V GMIKLALS ASGLAHLHMEIVGTQGKPAIAHRD+KSKNILVKK TC IADLGLAV+H
Sbjct: 289 VAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKH 348
Query: 359 DSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIG 418
DS +TIDI N +VGTKRYMAPE+LDD++N+ FESFKRADIY++GLV+WEIARRCS+G
Sbjct: 349 DSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVG 408
Query: 419 GIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYAN 478
GI E+YQLPYYD+VPSDPS+EEMRKVVC+QK RP+IPN+WQSCEALRVM +IMRECWYAN
Sbjct: 409 GIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYAN 468
Query: 479 GAARLTALRIKKTLSQLSQQEGIK 502
GAARLTALRIKKT+SQL +E K
Sbjct: 469 GAARLTALRIKKTISQLCVKEDCK 492
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 637 bits (1643), Expect = 0.0
Identities = 312/313 (99%), Positives = 313/313 (100%)
Query: 191 SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 250
+GLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ
Sbjct: 114 TGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 173
Query: 251 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 310
TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA
Sbjct: 174 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 233
Query: 311 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 370
SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN
Sbjct: 234 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 293
Query: 371 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 430
HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD
Sbjct: 294 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 353
Query: 431 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 490
LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK
Sbjct: 354 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 413
Query: 491 TLSQLSQQEGIKM 503
TLSQLSQQEGIKM
Sbjct: 414 TLSQLSQQEGIKM 426
Score = 237 bits (605), Expect = 2e-62
Identities = 114/114 (100%), Positives = 114/114 (100%)
Query: 1 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE 60
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
Sbjct: 1 MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE 60
Query: 61 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTT 114
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTT
Sbjct: 61 TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTT 114
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 624 bits (1610), Expect = e-179
Identities = 316/469 (67%), Positives = 367/469 (78%), Gaps = 15/469 (3%)
Query: 2 EAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTET 61
E+A A+ L++L+LA + + G AL C C C + N+TC TDG C VS+
Sbjct: 3 ESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIFNL 59
Query: 62 TDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL--PTTVKSSP 119
H CI +++L+P +PF C S + T+CC D+CN+I+L P+ P
Sbjct: 60 DGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLKEP 116
Query: 120 G----LGPVELAAVIAGPV--CFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISE 173
GPVEL +IAGPV F+ I ++ +V H R + + + EDPS + +S+
Sbjct: 117 EHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEM-CLSK 175
Query: 174 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKI 233
TL+DL+YD++TSGSGSGLPL VQRT+ARTIVLQE IGKGRFGEVWRG+WRG +VAVKI
Sbjct: 176 DKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKI 235
Query: 234 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 293
FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN
Sbjct: 236 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 295
Query: 294 RYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLG 353
RYTVT+EGMIKLALS ASGLAHLHMEIVGTQGKP IAHRDLKSKNILVKKNG C IADLG
Sbjct: 296 RYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLG 355
Query: 354 LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR 413
LAVRHD+ TDTIDIAPN RVGTKRYMAPEVLD++INMKHF+SFK ADIYA+GLV+WEIAR
Sbjct: 356 LAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIAR 415
Query: 414 RCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCE 462
RC+ GG+HE+YQLPYYDLVPSDPS+EEMRKVVC+QKLRPNIPN WQS E
Sbjct: 416 RCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE 464
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 623 bits (1607), Expect = e-178
Identities = 307/415 (73%), Positives = 350/415 (84%), Gaps = 4/415 (0%)
Query: 92 TGSVTTTYCCNQDHCNKI--ELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICH 149
+ +VT T CC D CN I LPT ++P LGP+ELA +I PVC + I+ ML V+ C
Sbjct: 28 SNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQ 87
Query: 150 NRTVIHHRV--PNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVL 207
R + + PN E+P + ++ G TLKDLIYD+T SGSGSGLPLLVQRTIARTIVL
Sbjct: 88 GRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVL 147
Query: 208 QESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADN 267
QE +GKGRFGEVW G+W GE+VAVKIFSSR+ERSWFREAEIYQTVMLRHENILGFIAADN
Sbjct: 148 QEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADN 207
Query: 268 KDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKP 327
KDNGTWTQLWLVS+YHE GSL+DYLNR VTV GMIKLALS ASGLAHLHMEIVGTQGKP
Sbjct: 208 KDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKP 267
Query: 328 AIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDS 387
AIAHRD+KSKNILVKK TC IADLGLAV+HDS +TIDI N +VGTKRYMAPE+LDD+
Sbjct: 268 AIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDT 327
Query: 388 INMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCE 447
+N+ FESFKRADIY++GLV+WEIARRCS+GGI E+YQLPYYD+VPSDPS+EEMRKVVC+
Sbjct: 328 MNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCD 387
Query: 448 QKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIK 502
QK RP+IPN+WQSCEALRVM +IMRECWYANGAARLTALRIKKT+SQL +E K
Sbjct: 388 QKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 442
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 542 bits (1397), Expect = e-154
Identities = 279/426 (65%), Positives = 326/426 (76%), Gaps = 15/426 (3%)
Query: 2 EAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTET 61
E+A A+ L++L+LA + + G AL C C C + N+TC TDG C VS+
Sbjct: 3 ESAGASSFFPLVVLLLAGSGGSGPR---GVQALLCACTSCLQANYTCETDGACMVSIFNL 59
Query: 62 TDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL--PTTVKSSP 119
H CI +++L+P +PF C S + T+CC D+CN+I+L P+ P
Sbjct: 60 DGMEHHVRTCIPKVELVPAGKPFYCLSSE---DLRNTHCCYTDYCNRIDLRVPSGHLKEP 116
Query: 120 G----LGPVELAAVIAGPV--CFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISE 173
GPVEL +IAGPV F+ I ++ +V H R + + + EDPS + +S+
Sbjct: 117 EHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEM-CLSK 175
Query: 174 GTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKI 233
TL+DL+YD++TSGSGSGLPL VQRT+ARTIVLQE IGKGRFGEVWRG+WRG +VAVKI
Sbjct: 176 DKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKI 235
Query: 234 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 293
FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN
Sbjct: 236 FSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN 295
Query: 294 RYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLG 353
RYTVT+EGMIKLALS ASGLAHLHMEIVGTQGKP IAHRDLKSKNILVKKNG C IADLG
Sbjct: 296 RYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLG 355
Query: 354 LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIAR 413
LAVRHD+ TDTIDIAPN RVGTKRYMAPEVLD++INMKHF+SFK ADIYA+GLV+WEIAR
Sbjct: 356 LAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIAR 415
Query: 414 RCSIGG 419
RC+ GG
Sbjct: 416 RCNSGG 421
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 537 bits (1383), Expect = e-152
Identities = 259/312 (83%), Positives = 287/312 (91%)
Query: 191 SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 250
+GLPLLVQRTIARTIVLQE +GKGRFGEVW G+W GE+VAVKIFSSR+ERSWFREAEIYQ
Sbjct: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
Query: 251 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 310
TVMLRHENILGFIAADNKDNGTWTQLWLVS+YHE GSL+DYLNR VTV GMIKLALS A
Sbjct: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
Query: 311 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 370
SGLAHLHMEIVGTQGKPAIAHRD+KSKNILVKK TC IADLGLAV+HDS +TIDI N
Sbjct: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
Query: 371 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 430
+VGTKRYMAPE+LDD++N+ FESFKRADIY++GLV+WEIARRCS+GGI E+YQLPYYD
Sbjct: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
Query: 431 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 490
+VPSDPS+EEMRKVVC+QK RP+IPN+WQSCEALRVM +IMRECWYANGAARLTALRIKK
Sbjct: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
Query: 491 TLSQLSQQEGIK 502
T+SQL +E K
Sbjct: 401 TISQLCVKEDCK 412
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/109 (41%), Positives = 53/109 (48%), Gaps = 15/109 (13%)
Query: 3 AAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETT 62
A +A R LLLL AAAA L PG L+C C LC NFTC T+G C+ SV T
Sbjct: 4 ALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVMLTN 54
Query: 63 DKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL 111
K C++ +P V SS +VT T CC D CN I L
Sbjct: 55 GKEQVIKSCVS----LPELNAQVFCHSS--NNVTKTECCFTDFCNNITL 97
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 494 bits (1272), Expect = e-140
Identities = 261/489 (53%), Positives = 333/489 (68%), Gaps = 15/489 (3%)
Query: 24 AAALLPGATALQCFCHL-CTKD--NFTCVTDGLCFVSVTETTDKV-IHNSMCIAEIDLIP 79
+ A P L+C CH C +D N C TDG CF + E + + S C+
Sbjct: 20 STAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGL----- 74
Query: 80 RDRPFVCAPSSKTGSVTTTYCCNQ-DHCNKIELPTT--VKSSPGL-GPVELAAVIAGPVC 135
F C + + CC + + CNK PT +K+ + GP+ A++ V
Sbjct: 75 EGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLIS-VT 133
Query: 136 FVCISLMLMVYICHNRTVIHHRVPNEE-DPSLDRPFISEGTTLKDLIYDMTTSGSGSGLP 194
+ L+L++ C+ R P D +I G +L+DLI +SGSGSGLP
Sbjct: 134 VCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLP 193
Query: 195 LLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVML 254
LLVQRTIA+ I + + IGKGR+GEVW GKWRGE+VAVK+F + EE SWFRE EIYQTV++
Sbjct: 194 LLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLM 253
Query: 255 RHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLA 314
RHENILGFIAAD K G+WTQL+L++DYHE+GSL+DYL T+ + M+KLA S+ SGL
Sbjct: 254 RHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLC 313
Query: 315 HLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVG 374
HLH EI TQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV+ S T+ +DI PN RVG
Sbjct: 314 HLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVG 373
Query: 375 TKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPS 434
TKRYM PEVLD+S+N HF+S+ AD+Y+ GL+ WE+ARRC GGI E+YQLPY+DLVPS
Sbjct: 374 TKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPS 433
Query: 435 DPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQ 494
DPS E+MR++VC +KLRP+ PNRW S E LR M K+M ECW N A+RLTALR+KKTL++
Sbjct: 434 DPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAK 493
Query: 495 LSQQEGIKM 503
+S+ + IK+
Sbjct: 494 MSESQDIKL 502
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 487 bits (1253), Expect = e-137
Identities = 255/485 (52%), Positives = 322/485 (66%), Gaps = 26/485 (5%)
Query: 34 LQCFCH-LCTKD--NFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSS 90
L+C+C C D N TC+T+G CF + E +A + F C S
Sbjct: 59 LKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQ----GETTLASGCMKYEGSDFQCKDSP 114
Query: 91 KTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCF--------VCISLM 142
K T CC + CN+ PT L PV + G + + VCI M
Sbjct: 115 KAQLRRTIECCRTNLCNQYLQPT-------LPPVVIGPFFDGSIRWLVLLISMAVCIIAM 167
Query: 143 LMVYIC----HNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQ 198
++ C H I R D D FI G +LKDLI +SGSGSGLPLLVQ
Sbjct: 168 IIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQ 227
Query: 199 RTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHEN 258
RTIA+ I + +GKGR+GEVW GKWRGE+VAVK+F + EE SWFRE EIYQTV++RHEN
Sbjct: 228 RTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHEN 287
Query: 259 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHM 318
ILGFIAAD K G+WTQL+L++DYHE+GSL+D+L T+ ++KLA S A GL HLH
Sbjct: 288 ILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHT 347
Query: 319 EIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY 378
EI GTQGKPAIAHRDLKSKNIL+KKNG+CCIADLGLAV+ +S T+ +D+ N RVGTKRY
Sbjct: 348 EIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRY 407
Query: 379 MAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSV 438
MAPEVLD+S+N HF+ + ADIY+ GL+ WE+ARRC GGI E+YQLPYY++VPSDPS
Sbjct: 408 MAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSY 467
Query: 439 EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQ 498
E+MR+VVC ++LRP + NRW S E LR + K+M ECW N A+RLTALRIKKTL+++ +
Sbjct: 468 EDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVES 527
Query: 499 EGIKM 503
+ +K+
Sbjct: 528 QDVKI 532
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 454 bits (1168), Expect = e-128
Identities = 235/406 (57%), Positives = 292/406 (71%), Gaps = 10/406 (2%)
Query: 100 CCNQDHCNK---IELPTTVKSSPGLGP--VELAAVIAGPVCFVCI-SLMLMVYICHNRTV 153
CC D CN+ +LPT KS PG +E+ +I V VC+ + +L V + +
Sbjct: 93 CCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRR 152
Query: 154 IHHRV-PNEEDPSLDRPFISEG---TTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQE 209
R+ P + + I+ +TL DL+ TSGSGSGLP LVQRT+AR I L E
Sbjct: 153 NQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLE 212
Query: 210 SIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKD 269
+GKGR+GEVWRG W+GE VAVKIFSSR+E+SWFRE E+Y TVMLRHENILGFIA+D
Sbjct: 213 CVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTS 272
Query: 270 NGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAI 329
+ TQLWL++ YHE GSL+DYL T+ +++ LS ASGLAHLH+EI GTQGKPAI
Sbjct: 273 RHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAI 332
Query: 330 AHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSIN 389
AHRDLKSKNILVKKNG CCIADLGLAV H +T+ +D+ N RVGTKRYMAPEVLD++I
Sbjct: 333 AHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ 392
Query: 390 MKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQK 449
+ F+S+KR DI+A GLV WE+ARR GI EDY+ P+YD+VP+DPS E+MRKVVC +
Sbjct: 393 VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQ 452
Query: 450 LRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 495
RPNIPNRW S L +AK+M+ECWY N +ARLTALRIKKTL+++
Sbjct: 453 QRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 454 bits (1168), Expect = e-128
Identities = 235/406 (57%), Positives = 292/406 (71%), Gaps = 10/406 (2%)
Query: 100 CCNQDHCNK---IELPTTVKSSPGLGP--VELAAVIAGPVCFVCI-SLMLMVYICHNRTV 153
CC D CN+ +LPT KS PG +E+ +I V VC+ + +L V + +
Sbjct: 93 CCQGDWCNRNITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRR 152
Query: 154 IHHRV-PNEEDPSLDRPFISEG---TTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQE 209
R+ P + + I+ +TL DL+ TSGSGSGLP LVQRT+AR I L E
Sbjct: 153 NQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLE 212
Query: 210 SIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKD 269
+GKGR+GEVWRG W+GE VAVKIFSSR+E+SWFRE E+Y TVMLRHENILGFIA+D
Sbjct: 213 CVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTS 272
Query: 270 NGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAI 329
+ TQLWL++ YHE GSL+DYL T+ +++ LS ASGLAHLH+EI GTQGKPAI
Sbjct: 273 RHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAI 332
Query: 330 AHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSIN 389
AHRDLKSKNILVKKNG CCIADLGLAV H +T+ +D+ N RVGTKRYMAPEVLD++I
Sbjct: 333 AHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ 392
Query: 390 MKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQK 449
+ F+S+KR DI+A GLV WE+ARR GI EDY+ P+YD+VP+DPS E+MRKVVC +
Sbjct: 393 VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQ 452
Query: 450 LRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 495
RPNIPNRW S L +AK+M+ECWY N +ARLTALRIKKTL+++
Sbjct: 453 QRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 498
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 424 bits (1090), Expect = e-119
Identities = 224/411 (54%), Positives = 274/411 (66%), Gaps = 18/411 (4%)
Query: 99 YCCNQDHCN---KIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH 155
YCC+ CN + L T S G A+I GPV + + L V + H
Sbjct: 88 YCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVL-----GLWH 142
Query: 156 HRVPNEEDPSLDRPFISEGTTLK----------DLIYDMTTSGSGSGLPLLVQRTIARTI 205
R E+ L LK DL+ T+GSGSGLP LVQRT+AR +
Sbjct: 143 VRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQV 202
Query: 206 VLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAA 265
L E +GKGR+GEVWRG W GE VAVKIFSSR+E+SWFRE EIY TV+LRH+NILGFIA+
Sbjct: 203 ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS 262
Query: 266 DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQG 325
D + TQLWL++ YHEHGSL+D+L R T+ ++LA+S A GLAHLH+EI GTQG
Sbjct: 263 DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG 322
Query: 326 KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLD 385
KPAIAHRD KS+N+LVK N CCIADLGLAV H +D +DI N RVGTKRYMAPEVLD
Sbjct: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 382
Query: 386 DSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVV 445
+ I FES+K DI+A GLV WEIARR + GI EDY+ P+YD+VP+DPS E+M+KVV
Sbjct: 383 EQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVV 442
Query: 446 CEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLS 496
C + P IPNR + L +A++MRECWY N +ARLTALRIKKTL ++S
Sbjct: 443 CVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKIS 493
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 424 bits (1090), Expect = e-119
Identities = 224/411 (54%), Positives = 274/411 (66%), Gaps = 18/411 (4%)
Query: 99 YCCNQDHCN---KIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIH 155
YCC+ CN + L T S G A+I GPV + + L V + H
Sbjct: 88 YCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVL-----GLWH 142
Query: 156 HRVPNEEDPSLDRPFISEGTTLK----------DLIYDMTTSGSGSGLPLLVQRTIARTI 205
R E+ L LK DL+ T+GSGSGLP LVQRT+AR +
Sbjct: 143 VRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQV 202
Query: 206 VLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAA 265
L E +GKGR+GEVWRG W GE VAVKIFSSR+E+SWFRE EIY TV+LRH+NILGFIA+
Sbjct: 203 ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS 262
Query: 266 DNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQG 325
D + TQLWL++ YHEHGSL+D+L R T+ ++LA+S A GLAHLH+EI GTQG
Sbjct: 263 DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG 322
Query: 326 KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLD 385
KPAIAHRD KS+N+LVK N CCIADLGLAV H +D +DI N RVGTKRYMAPEVLD
Sbjct: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 382
Query: 386 DSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVV 445
+ I FES+K DI+A GLV WEIARR + GI EDY+ P+YD+VP+DPS E+M+KVV
Sbjct: 383 EQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVV 442
Query: 446 CEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLS 496
C + P IPNR + L +A++MRECWY N +ARLTALRIKKTL ++S
Sbjct: 443 CVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKIS 493
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 395 bits (1015), Expect = e-110
Identities = 189/234 (80%), Positives = 212/234 (90%)
Query: 269 DNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPA 328
DNGTWTQLWLVS+YHE GSL+DYLNR VTV GMIKLALS ASGLAHLHMEIVGTQGKPA
Sbjct: 102 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPA 161
Query: 329 IAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSI 388
IAHRD+KSKNILVKK TC IADLGLAV+HDS +TIDI N +VGTKRYMAPE+LDD++
Sbjct: 162 IAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTM 221
Query: 389 NMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQ 448
N+ FESFKRADIY++GLV+WEIARRCS+GGI E+YQLPYYD+VPSDPS+EEMRKVVC+Q
Sbjct: 222 NVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQ 281
Query: 449 KLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIK 502
K RP+IPN+WQSCEALRVM +IMRECWYANGAARLTALRIKKT+SQL +E K
Sbjct: 282 KFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 335
Score = 61.2 bits (147), Expect = 2e-09
Identities = 45/109 (41%), Positives = 53/109 (48%), Gaps = 15/109 (13%)
Query: 3 AAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETT 62
A +A R LLLL AAAA L PG L+C C LC NFTC T+G C+ SV T
Sbjct: 4 ALCSALRQALLLL------AAAAELSPG---LKCVCLLCDSSNFTCQTEGACWASVMLTN 54
Query: 63 DKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIEL 111
K C++ +P V SS +VT T CC D CN I L
Sbjct: 55 GKEQVIKSCVS----LPELNAQVFCHSS--NNVTKTECCFTDFCNNITL 97
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 234 bits (598), Expect = 1e-61
Identities = 145/417 (34%), Positives = 223/417 (53%), Gaps = 15/417 (3%)
Query: 91 KTGSVTTTYCCNQDHCNK--IELPTTVKSSPGLGPV--ELAAVIAGPVCFVCISLMLMVY 146
K G C+ D CN I S+P L V ++ + P V IS++++ Y
Sbjct: 128 KPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFY 187
Query: 147 ICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIV 206
C+ R ++ + + R + ++ D + S + + T I
Sbjct: 188 -CY-RVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE 245
Query: 207 LQESIGKGRFGEVWRGKWRG------EEVAVKIFSSREERSWFREAEIYQTVMLRHENIL 260
L +GKGRF EV++ K + E VAVKIF E SW E +I+ + L+HENIL
Sbjct: 246 LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENIL 305
Query: 261 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEI 320
F+ A+ + Q WL++ +H G+L +YL R+ ++ E + KL S A G+AHLH +
Sbjct: 306 QFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDH 365
Query: 321 VGTQGKPA--IAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY 378
G+P I HRDLKS NILVK + TCC+ D GL++R D D+A + +VGT RY
Sbjct: 366 TPC-GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARY 424
Query: 379 MAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSV 438
MAPEVL+ +N+++ ESFK+ D+Y+M LV WE+ RC+ G +DY+ P+ V P V
Sbjct: 425 MAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCV 484
Query: 439 EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 495
E M+ V + RP IP+ W + + ++++ + + ECW + ARLTA + + S+L
Sbjct: 485 ESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 234 bits (598), Expect = 1e-61
Identities = 145/417 (34%), Positives = 223/417 (53%), Gaps = 15/417 (3%)
Query: 91 KTGSVTTTYCCNQDHCNK--IELPTTVKSSPGLGPV--ELAAVIAGPVCFVCISLMLMVY 146
K G C+ D CN I S+P L V ++ + P V IS++++ Y
Sbjct: 153 KPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFY 212
Query: 147 ICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIV 206
C+ R ++ + + R + ++ D + S + + T I
Sbjct: 213 -CY-RVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE 270
Query: 207 LQESIGKGRFGEVWRGKWRG------EEVAVKIFSSREERSWFREAEIYQTVMLRHENIL 260
L +GKGRF EV++ K + E VAVKIF E SW E +I+ + L+HENIL
Sbjct: 271 LDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENIL 330
Query: 261 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEI 320
F+ A+ + Q WL++ +H G+L +YL R+ ++ E + KL S A G+AHLH +
Sbjct: 331 QFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDH 390
Query: 321 VGTQGKPA--IAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY 378
G+P I HRDLKS NILVK + TCC+ D GL++R D D+A + +VGT RY
Sbjct: 391 TPC-GRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARY 449
Query: 379 MAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSV 438
MAPEVL+ +N+++ ESFK+ D+Y+M LV WE+ RC+ G +DY+ P+ V P V
Sbjct: 450 MAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCV 509
Query: 439 EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 495
E M+ V + RP IP+ W + + ++++ + + ECW + ARLTA + + S+L
Sbjct: 510 ESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 566
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 232 bits (592), Expect = 5e-61
Identities = 141/409 (34%), Positives = 222/409 (54%), Gaps = 31/409 (7%)
Query: 100 CCNQDHCNK--IELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLM--VYICHNRTVIH 155
CC + CN+ P + P PV + + + LML+ + IC H
Sbjct: 104 CCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRH 163
Query: 156 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR 215
H++ ++ G PLL + + L E +GR
Sbjct: 164 HKM-----------------AYPPVLVPTQDPGPPPPSPLLGLKPLQ----LLEVKARGR 202
Query: 216 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ 275
FG VW+ + E VAVKIF ++++SW E E+Y ++HENIL FI A+ +
Sbjct: 203 FGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVD 262
Query: 276 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQG--KPAIAHRD 333
LWL++ +HE GSL D+L V+ + +A + A GLA+LH +I G + KPAI+HRD
Sbjct: 263 LWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRD 322
Query: 334 LKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHF 393
+KSKN+L+K N T CIAD GLA++ ++ D + +VGT+RYMAPEVL+ +IN +
Sbjct: 323 IKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQR- 379
Query: 394 ESFKRADIYAMGLVFWEIARRCSIG-GIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRP 452
++F R D+YAMGLV WE+A RC+ G ++Y LP+ + + PS+E+M++VV +K RP
Sbjct: 380 DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRP 439
Query: 453 NIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGI 501
+ + WQ + ++ + + ECW + ARL+A + + ++Q+ + I
Sbjct: 440 VLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 221 bits (563), Expect = 1e-57
Identities = 117/295 (39%), Positives = 186/295 (63%), Gaps = 7/295 (2%)
Query: 203 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 262
+ + L E +GRFG VW+ + + VAVKIF ++++SW E EI+ T ++HEN+L F
Sbjct: 188 KPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 247
Query: 263 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVG 322
IAA+ + + +LWL++ +H+ GSL DYL +T + +A + + GL++LH ++
Sbjct: 248 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPW 307
Query: 323 TQG---KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 379
+G KP+IAHRD KSKN+L+K + T +AD GLAVR + D + +VGT+RYM
Sbjct: 308 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYM 365
Query: 380 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC-SIGGIHEDYQLPYYDLVPSDPSV 438
APEVL+ +IN + ++F R D+YAMGLV WE+ RC + G ++Y LP+ + + PS+
Sbjct: 366 APEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
Query: 439 EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLS 493
EE+++VV +K+RP I + W L + + ECW + ARL+A +++ +S
Sbjct: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVS 479
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 196 bits (499), Expect = 3e-50
Identities = 114/300 (38%), Positives = 176/300 (58%), Gaps = 11/300 (3%)
Query: 207 LQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAAD 266
L E IG+GR+G V++G VAVK+FS +++ E IY+ ++ H+NI FI D
Sbjct: 205 LLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGD 264
Query: 267 NKDNGTW-TQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIV-GTQ 324
+ + LV +Y+ +GSL YL+ +T +LA S GLA+LH E+ G
Sbjct: 265 ERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDH 324
Query: 325 GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS----ATDTIDIAPNHRVGTKRYMA 380
KPAI+HRDL S+N+LVK +GTC I+D GL++R D A VGT RYMA
Sbjct: 325 YKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMA 384
Query: 381 PEVLDDSINMKHFES-FKRADIYAMGLVFWEIARRCS---IGGIHEDYQLPYYDLVPSDP 436
PEVL+ ++N++ ES K+ D+YA+GL++WEI RC+ G +YQ+ + V + P
Sbjct: 385 PEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHP 444
Query: 437 SVEEMRKVVCEQKLRPNIPNRW-QSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 495
+ E+M+ +V +K RP P W ++ A+R + + + +CW + ARLTA ++ +++L
Sbjct: 445 TFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL 504
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 167 bits (423), Expect = 2e-41
Identities = 137/447 (30%), Positives = 212/447 (47%), Gaps = 59/447 (13%)
Query: 86 CAPSSKT----GSVTTTYCCNQDHCNKIELPTTVKSSPGL----GP-------VELAAVI 130
C PS + GS T C D CN SPG GP + +A V+
Sbjct: 92 CDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVL 151
Query: 131 AGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSG 190
G F+ + L+L I ++RV E P RP
Sbjct: 152 LG--LFLLLLLLLGSIILALLQRKNYRVRGEPVPE-PRP--------------------D 188
Query: 191 SGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 250
SG V+ + + I +G VW G+ +G+ VA+K F R + E +Y+
Sbjct: 189 SGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYE 248
Query: 251 TVMLRHENILGFIAADNKDNGTWTQ-LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALST 309
L+H++I+ FI A G LV + H GSL YL +YT +++ALS
Sbjct: 249 LPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSL 308
Query: 310 ASGLAHLHMEI-VGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIA 368
A GLA LH E Q KP IAHRDL S+N+L++++G+C I DLGLA+ T
Sbjct: 309 AQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWT 368
Query: 369 PNH--------RVGTKRYMAPEVLDDSINMKHF-ESFKRADIYAMGLVFWEIARRCSIGG 419
P GT+RYMAPE+LD +++++ + + +RADIY++ L+ WEI RC
Sbjct: 369 PTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCP--D 426
Query: 420 IHED-----YQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRV--MAKIMR 472
+ D +QL Y + + P+ +E+ + +++ RP IP+ W+ C A + +++
Sbjct: 427 LRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWR-CFATDPDGLRELLE 485
Query: 473 ECWYANGAARLTALRIKKTLSQLSQQE 499
+CW A+ ARLTA +++ L+ L+ +
Sbjct: 486 DCWDADPEARLTAECVQQRLAALAHPQ 512
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 95.1 bits (235), Expect = 1e-19
Identities = 80/300 (26%), Positives = 142/300 (47%), Gaps = 48/300 (16%)
Query: 203 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 262
+ + L ++IGKG FG+V G +RG +VAVK + F AE LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFL-AEASVMTQLRHSNLVQL 251
Query: 263 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEG---MIKLALSTASGLAHLHME 319
+ ++ G L++V++Y GSL DYL +V G ++K +L + +L
Sbjct: 252 LGVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL--- 305
Query: 320 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 379
+G + HRDL ++N+LV ++ ++D GL S DT + ++
Sbjct: 306 ----EGNNFV-HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-------PVKWT 353
Query: 380 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVE 439
APE L + K F + ++D+++ G++ WEI S G + ++P D+V P VE
Sbjct: 354 APEALRE----KKFST--KSDVWSFGILLWEI---YSFGRVPYP-RIPLKDVV---PRVE 400
Query: 440 EMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQE 499
+ K+ P + ++M+ CW+ + A R + L++++ L + E
Sbjct: 401 KGYKMDAPDGCPP-------------AVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHE 447
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 95.1 bits (235), Expect = 1e-19
Identities = 80/300 (26%), Positives = 142/300 (47%), Gaps = 48/300 (16%)
Query: 203 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 262
+ + L ++IGKG FG+V G +RG +VAVK + F AE LRH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFL-AEASVMTQLRHSNLVQL 251
Query: 263 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEG---MIKLALSTASGLAHLHME 319
+ ++ G L++V++Y GSL DYL +V G ++K +L + +L
Sbjct: 252 LGVIVEEKG---GLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYL--- 305
Query: 320 IVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYM 379
+G + HRDL ++N+LV ++ ++D GL S DT + ++
Sbjct: 306 ----EGNNFV-HRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL-------PVKWT 353
Query: 380 APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVE 439
APE L + K F + ++D+++ G++ WEI S G + ++P D+V P VE
Sbjct: 354 APEALRE----KKFST--KSDVWSFGILLWEI---YSFGRVPYP-RIPLKDVV---PRVE 400
Query: 440 EMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQE 499
+ K+ P + ++M+ CW+ + A R + L++++ L + E
Sbjct: 401 KGYKMDAPDGCPP-------------AVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHE 447
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 94.7 bits (234), Expect = 2e-19
Identities = 86/300 (28%), Positives = 140/300 (46%), Gaps = 57/300 (19%)
Query: 209 ESIGKGRFGEVWRGKW--RGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF--IA 264
E+ G G FG V+R KW + +EVAVK E +EAEI +L H NI+ F +
Sbjct: 20 ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72
Query: 265 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT---VTVEGMIKLALSTASGLAHLHMEIV 321
+ + G +V++Y GSL+DY+N + ++ ++ A A G+ +LHME
Sbjct: 73 LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124
Query: 322 GTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAP 381
+ HRDLKS+N+++ +G I D G + H+ T VGT +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175
Query: 382 EVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEM 441
EV+ + + D Y+ G+V WE+ R ++P+ L ++
Sbjct: 176 EVI------QSLPVSETCDTYSYGVVLWEMLTR----------EVPFKGL-----EGLQV 214
Query: 442 RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGI 501
+V E+ R IP+ SC R A+++ +CW A+ R + +I L +S +
Sbjct: 215 AWLVVEKNERLTIPS---SCP--RSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSL 269
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 94.7 bits (234), Expect = 2e-19
Identities = 86/300 (28%), Positives = 140/300 (46%), Gaps = 57/300 (19%)
Query: 209 ESIGKGRFGEVWRGKW--RGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF--IA 264
E+ G G FG V+R KW + +EVAVK E +EAEI +L H NI+ F +
Sbjct: 20 ENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQFYGVI 72
Query: 265 ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT---VTVEGMIKLALSTASGLAHLHMEIV 321
+ + G +V++Y GSL+DY+N + ++ ++ A A G+ +LHME
Sbjct: 73 LEPPNYG------IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME-- 124
Query: 322 GTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAP 381
+ HRDLKS+N+++ +G I D G + H+ T VGT +MAP
Sbjct: 125 ---APVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM------SLVGTFPWMAP 175
Query: 382 EVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEM 441
EV+ + + D Y+ G+V WE+ R ++P+ L ++
Sbjct: 176 EVI------QSLPVSETCDTYSYGVVLWEMLTR----------EVPFKGL-----EGLQV 214
Query: 442 RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGI 501
+V E+ R IP+ SC R A+++ +CW A+ R + +I L +S +
Sbjct: 215 AWLVVEKNERLTIPS---SCP--RSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSL 269
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/217 (29%), Positives = 101/217 (46%), Gaps = 30/217 (13%)
Query: 203 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 262
+ I ++E +G+G FG V + KWR ++VA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 263 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT----VTVEGMIKLALSTASGLAHLHM 318
A + LV +Y E GSL++ L+ T + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 319 EIVGTQGKPAIAHRDLKSKNILVKKNGTCC-IADLGLAVRHDSATDTIDIAPNHRVGTKR 377
+ A+ HRDLK N+L+ GT I D G A I + G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 378 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARR 414
+MAPEV + S ++ D+++ G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/217 (29%), Positives = 101/217 (46%), Gaps = 30/217 (13%)
Query: 203 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 262
+ I ++E +G+G FG V + KWR ++VA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 263 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT----VTVEGMIKLALSTASGLAHLHM 318
A + LV +Y E GSL++ L+ T + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 319 EIVGTQGKPAIAHRDLKSKNILVKKNGTCC-IADLGLAVRHDSATDTIDIAPNHRVGTKR 377
+ A+ HRDLK N+L+ GT I D G A I + G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 378 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARR 414
+MAPEV + S ++ D+++ G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/217 (29%), Positives = 101/217 (46%), Gaps = 30/217 (13%)
Query: 203 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 262
+ I ++E +G+G FG V + KWR ++VA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 263 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT----VTVEGMIKLALSTASGLAHLHM 318
A + LV +Y E GSL++ L+ T + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 319 EIVGTQGKPAIAHRDLKSKNILVKKNGTCC-IADLGLAVRHDSATDTIDIAPNHRVGTKR 377
+ A+ HRDLK N+L+ GT I D G A I + G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 378 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARR 414
+MAPEV + S ++ D+++ G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/217 (29%), Positives = 101/217 (46%), Gaps = 30/217 (13%)
Query: 203 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 262
+ I ++E +G+G FG V + KWR ++VA+K S ER F E+ Q + H NI+
Sbjct: 34 KEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF-IVELRQLSRVNHPNIVKL 92
Query: 263 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT----VTVEGMIKLALSTASGLAHLHM 318
A + LV +Y E GSL++ L+ T + L + G+A+LH
Sbjct: 93 YGA------CLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH- 145
Query: 319 EIVGTQGKPAIAHRDLKSKNILVKKNGTCC-IADLGLAVRHDSATDTIDIAPNHRVGTKR 377
+ A+ HRDLK N+L+ GT I D G A I + G+
Sbjct: 146 ----SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-------DIQTHMTNNKGSAA 194
Query: 378 YMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARR 414
+MAPEV + S ++ D+++ G++ WE+ R
Sbjct: 195 WMAPEVFEGS------NYSEKCDVFSWGIILWEVITR 225
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 84.3 bits (207), Expect = 2e-16
Identities = 71/217 (32%), Positives = 108/217 (49%), Gaps = 28/217 (12%)
Query: 202 ARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFS----SREERSWFREAEIYQTVMLRHE 257
A ++L IG G FG V++GKW G +VAVKI + E+ FR E+ RH
Sbjct: 346 ASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRN-EVAVLRKTRHV 403
Query: 258 NILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE--GMIKLALSTASGLAH 315
NIL F+ KDN L +V+ + E SL+ +L+ + +I +A TA G+ +
Sbjct: 404 NILLFMGYMTKDN-----LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 458
Query: 316 LHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGT 375
LH + I HRD+KS NI + + T I D GLA + + + G+
Sbjct: 459 LHAK--------NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV--EQPTGS 508
Query: 376 KRYMAPEVLDDSINMKHFESFK-RADIYAMGLVFWEI 411
+MAPEV I M+ F ++D+Y+ G+V +E+
Sbjct: 509 VLWMAPEV----IRMQDNNPFSFQSDVYSYGIVLYEL 541
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,249,762
Number of Sequences: 37866
Number of extensions: 871539
Number of successful extensions: 3678
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 304
Number of HSP's successfully gapped in prelim test: 414
Number of HSP's that attempted gapping in prelim test: 2606
Number of HSP's gapped (non-prelim): 807
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.