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Search of human proteins with 4758532
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758532 ral guanine nucleotide dissociation stimulator-like
2 [Homo sapiens]
(777 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 1548 0.0
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 387 e-107
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 384 e-106
gi|24307909 ral guanine nucleotide dissociation stimulator isofo... 377 e-104
gi|108796058 ral guanine nucleotide dissociation stimulator isof... 377 e-104
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 355 9e-98
gi|23957680 ral guanine nucleotide dissociation stimulator-like ... 171 2e-42
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 102 1e-21
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 102 1e-21
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 100 4e-21
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 97 4e-20
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 97 6e-20
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 91 4e-18
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 90 9e-18
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 90 9e-18
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 90 9e-18
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 89 2e-17
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 89 2e-17
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 86 2e-16
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 81 3e-15
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 81 4e-15
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 79 2e-14
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 75 2e-13
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 75 2e-13
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 70 6e-12
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 70 1e-11
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 69 2e-11
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 69 2e-11
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 69 2e-11
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 66 1e-10
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 1548 bits (4009), Expect = 0.0
Identities = 777/777 (100%), Positives = 777/777 (100%)
Query: 1 MLPRPLRLLLDTSPPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDE 60
MLPRPLRLLLDTSPPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDE
Sbjct: 1 MLPRPLRLLLDTSPPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDE 60
Query: 61 EEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAF 120
EEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAF
Sbjct: 61 EEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAF 120
Query: 121 LATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKG 180
LATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKG
Sbjct: 121 LATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKG 180
Query: 181 QLDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPADPTDVL 240
QLDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPADPTDVL
Sbjct: 181 QLDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPADPTDVL 240
Query: 241 VFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGA 300
VFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGA
Sbjct: 241 VFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGA 300
Query: 301 VVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQS 360
VVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQS
Sbjct: 301 VVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQS 360
Query: 361 SPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPR 420
SPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPR
Sbjct: 361 SPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPR 420
Query: 421 SGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGY 480
SGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGY
Sbjct: 421 SGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGY 480
Query: 481 NLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSV 540
NLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSV
Sbjct: 481 NLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSV 540
Query: 541 GVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPSH 600
GVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPSH
Sbjct: 541 GVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPSH 600
Query: 601 LSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGE 660
LSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGE
Sbjct: 601 LSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGE 660
Query: 661 DGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYA 720
DGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYA
Sbjct: 661 DGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYA 720
Query: 721 MDGASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF 777
MDGASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF
Sbjct: 721 MDGASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF 777
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 387 bits (994), Expect = e-107
Identities = 277/735 (37%), Positives = 376/735 (51%), Gaps = 96/735 (13%)
Query: 53 APVSVWDEE-EDGAVFTVTSRQYR---------PLDPLVPMPPPRSS--------RRLRA 94
AP+ W EE EDGAV++V+ R+ R P P P + R LRA
Sbjct: 12 APLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRA 71
Query: 95 GTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTDELER 154
LE LV L+ D SFM AFLAT+R F T LLG + + P E+++
Sbjct: 72 ARLERLVGELVFGDRE-QDPSFMPAFLATYRTFVPTACLLGFLLPPMPP-PPPPGVEIKK 129
Query: 155 TT----------EVAISVLSTWLASHPEDFGSE-AKGQLDRLESFLLQTGYAAGKGVGGG 203
T +SVL +WL HP+DF A L + +FL G+AA
Sbjct: 130 TAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFL---GWAAPGSAEAQ 186
Query: 204 SA-----DLIRNLRSRVDPQAPDL---PKPLALPGDPPADPT-------------DVLVF 242
A D + + + P + P +A DP + +L F
Sbjct: 187 KAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF 246
Query: 243 LADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVV 302
D +AEQLTL+D ELF + +CLG +W RDRPG + P+VRATV QFN V G V+
Sbjct: 247 SVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVL 306
Query: 303 SSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSP 362
SVLGA PG L PQRA+ LEKWIR+A+ CR LRNFSS+ A++SALQS+P
Sbjct: 307 GSVLGA------PG------LAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNP 354
Query: 363 IHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSG 422
I+RL+ +WG +R+ L F L QIFS+E+N+ SRE+L QE + E +
Sbjct: 355 IYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPS 414
Query: 423 SRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNL 482
G VPYLGTFL DLVMLD A D LE INF+KRRKE+ +L+ +++LQ C+ Y L
Sbjct: 415 KPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTL 474
Query: 483 QPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGV 542
P I L LTE QS+R+S +EPP +S P +PR+ R + + + L
Sbjct: 475 SPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKS 534
Query: 543 PTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPS--- 599
+P S G +PT+ + ++ S S D+ S P+ P PS
Sbjct: 535 SSP-----SGSPGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKL 589
Query: 600 HLSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELG 659
LS SPRP + GSP + S S+ R+IRV ++
Sbjct: 590 PLSLDLPSPRPF-----ALPLGSPRIPLPAQQS--------------SEARVIRVSID-N 629
Query: 660 EDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFY 719
+ G++Y+SIL+TSQDKAPSV+ R L+K+N A +Y+L Q+LPG+R L IP +ANVFY
Sbjct: 630 DHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFY 689
Query: 720 AMDG-ASHDFLLRQR 733
AM A DF+LR++
Sbjct: 690 AMSPVAPRDFMLRRK 704
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 384 bits (986), Expect = e-106
Identities = 277/735 (37%), Positives = 372/735 (50%), Gaps = 102/735 (13%)
Query: 53 APVSVWDEE-EDGAVFTVTSRQYR---------PLDPLVPMPPPRSS--------RRLRA 94
AP+ W EE EDGAV++V+ R+ R P P P + R LRA
Sbjct: 12 APLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRA 71
Query: 95 GTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTDELER 154
LE LV L+ D SFM AFLAT+R F T LLG + + P E+++
Sbjct: 72 ARLERLVGELVFGDRE-QDPSFMPAFLATYRTFVPTACLLGFLLPPMPP-PPPPGVEIKK 129
Query: 155 TT----------EVAISVLSTWLASHPEDFGSE-AKGQLDRLESFLLQTGYAAGKGVGGG 203
T +SVL +WL HP+DF A L + +FL G+AA
Sbjct: 130 TAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFL---GWAAPGSAEAQ 186
Query: 204 SA-----DLIRNLRSRVDPQAPDL---PKPLALPGDPPADPT-------------DVLVF 242
A D + + + P + P +A DP + +L F
Sbjct: 187 KAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQGPQLLDF 246
Query: 243 LADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVV 302
D +AEQLTL+D ELF + +CLG +W RDRPG + P+VRATV QFN V G V+
Sbjct: 247 SVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVL 306
Query: 303 SSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSP 362
SVLGA PG L PQRA+ LEKWIR+A+ CR LRNFSS+ A++SALQS+P
Sbjct: 307 GSVLGA------PG------LAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNP 354
Query: 363 IHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSG 422
I+RL+ +WG +R+ L F L QIFS+E+N+ SRE+L QE + E +
Sbjct: 355 IYRLKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPS 414
Query: 423 SRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNL 482
G VPYLGTFL DLVMLD A D LE INF+KRRKE+ +L+ +++LQ C+ Y L
Sbjct: 415 KPPPGPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTL 474
Query: 483 QPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGV 542
P I L LTE QS+R+S +EPP +S P +PR+ R + + + L
Sbjct: 475 SPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKS 534
Query: 543 PTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPS--- 599
+P S PS+ P S S D+ S P+ P PS
Sbjct: 535 SSPSGSPGDPSSPTSSVSPGSPP-----------SSPRSRDAPAGSPPASPGPQGPSTKL 583
Query: 600 HLSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELG 659
LS SPRP + GSP + S S+ R+IRV ++
Sbjct: 584 PLSLDLPSPRPF-----ALPLGSPRIPLPAQQS--------------SEARVIRVSID-N 623
Query: 660 EDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFY 719
+ G++Y+SIL+TSQDKAPSV+ R L+K+N A +Y+L Q+LPG+R L IP +ANVFY
Sbjct: 624 DHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFY 683
Query: 720 AMDG-ASHDFLLRQR 733
AM A DF+LR++
Sbjct: 684 AMSPVAPRDFMLRRK 698
>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
1 [Homo sapiens]
Length = 914
Score = 377 bits (969), Expect = e-104
Identities = 233/594 (39%), Positives = 331/594 (55%), Gaps = 78/594 (13%)
Query: 220 PDLPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPG 279
P P P+ + +LVF D +AEQ TL+DAELF ++P CLG +W RD+ G
Sbjct: 363 PSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKG 422
Query: 280 HSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVA 339
HL P++RATVTQFN VA V+++ LG ST + P RAR++E WI VA
Sbjct: 423 KEHLAPTIRATVTQFNSVANCVITTCLGNRST------------KAPDRARVVEHWIEVA 470
Query: 340 EECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRE 399
ECR+L+NFSS+YA++SALQS+ IHRL+ W + +RDS R+F L +IFS+E+NYS SRE
Sbjct: 471 RECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRE 530
Query: 400 LLVQEVKLQ-SPLEPHSKKAPRSGSRGG---GVVPYLGTFLKDLVMLDAASKDELENGYI 455
LL++E + + LE + K+A + G G VPYLGTFL DLVMLD A KD L I
Sbjct: 531 LLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLI 590
Query: 456 NFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGS 515
NF+KRRKEF V+++++ LQ+ C Y++ PD W + + L+E +S+ +SCE+EPP
Sbjct: 591 NFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSE 650
Query: 516 SDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMK 575
S R + T ++ +W++ PST E T+ + Q
Sbjct: 651 SASNTLRTKKNTAIVKRWSD-------------RQAPST---ELSTSGSSHSKSCDQLRC 694
Query: 576 WPSVSSLDSA----LESSPSLHSPADPSHLS-PPASSPRPSRGHRRSASCGSPLSGGAEE 630
P +SS D A + S+ S S + ++S P S + SAS SP + G
Sbjct: 695 GPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISS 754
Query: 631 ASGGTGYGGEGSGPGAS--------------------------DCRIIRVQMELGEDGSV 664
AS T + P A+ DC IIRV +++ ++G++
Sbjct: 755 ASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDV-DNGNM 813
Query: 665 YKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYAMDG- 723
YKSILVTSQDKAP+VI + + K+N + +YEL+Q+L +R+L IP +ANVFYAM+
Sbjct: 814 YKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNST 873
Query: 724 ASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF 777
A++DF+L++R T T GV AS T PR+K G KIA+ +F
Sbjct: 874 ANYDFVLKKR----TFTKGVKVKHGASST---------LPRMKQKGLKIAKGIF 914
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/103 (35%), Positives = 55/103 (53%), Gaps = 22/103 (21%)
Query: 90 RRLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLM---ADRLEAL-- 144
R ++AGTLE LV HL+ G+D+S+++ FL T+RAFT+T +L L+ R +AL
Sbjct: 114 RTVKAGTLEKLVEHLVPA-FQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTA 172
Query: 145 -------------ESHPTDELERTTEVAISVLSTWLASHPEDF 174
+ P D+L+ S+L TWL + EDF
Sbjct: 173 SSRYGCILPYSDEDGGPQDQLKNAIS---SILGTWLDQYSEDF 212
>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
2 [Homo sapiens]
Length = 859
Score = 377 bits (969), Expect = e-104
Identities = 233/594 (39%), Positives = 331/594 (55%), Gaps = 78/594 (13%)
Query: 220 PDLPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPG 279
P P P+ + +LVF D +AEQ TL+DAELF ++P CLG +W RD+ G
Sbjct: 308 PSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKG 367
Query: 280 HSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVA 339
HL P++RATVTQFN VA V+++ LG ST + P RAR++E WI VA
Sbjct: 368 KEHLAPTIRATVTQFNSVANCVITTCLGNRST------------KAPDRARVVEHWIEVA 415
Query: 340 EECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRE 399
ECR+L+NFSS+YA++SALQS+ IHRL+ W + +RDS R+F L +IFS+E+NYS SRE
Sbjct: 416 RECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRE 475
Query: 400 LLVQEVKLQ-SPLEPHSKKAPRSGSRGG---GVVPYLGTFLKDLVMLDAASKDELENGYI 455
LL++E + + LE + K+A + G G VPYLGTFL DLVMLD A KD L I
Sbjct: 476 LLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLI 535
Query: 456 NFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGS 515
NF+KRRKEF V+++++ LQ+ C Y++ PD W + + L+E +S+ +SCE+EPP
Sbjct: 536 NFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSE 595
Query: 516 SDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMK 575
S R + T ++ +W++ PST E T+ + Q
Sbjct: 596 SASNTLRTKKNTAIVKRWSD-------------RQAPST---ELSTSGSSHSKSCDQLRC 639
Query: 576 WPSVSSLDSA----LESSPSLHSPADPSHLS-PPASSPRPSRGHRRSASCGSPLSGGAEE 630
P +SS D A + S+ S S + ++S P S + SAS SP + G
Sbjct: 640 GPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISS 699
Query: 631 ASGGTGYGGEGSGPGAS--------------------------DCRIIRVQMELGEDGSV 664
AS T + P A+ DC IIRV +++ ++G++
Sbjct: 700 ASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDV-DNGNM 758
Query: 665 YKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYAMDG- 723
YKSILVTSQDKAP+VI + + K+N + +YEL+Q+L +R+L IP +ANVFYAM+
Sbjct: 759 YKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNST 818
Query: 724 ASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF 777
A++DF+L++R T T GV AS T PR+K G KIA+ +F
Sbjct: 819 ANYDFVLKKR----TFTKGVKVKHGASST---------LPRMKQKGLKIAKGIF 859
Score = 55.1 bits (131), Expect = 2e-07
Identities = 37/103 (35%), Positives = 55/103 (53%), Gaps = 22/103 (21%)
Query: 90 RRLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLM---ADRLEAL-- 144
R ++AGTLE LV HL+ G+D+S+++ FL T+RAFT+T +L L+ R +AL
Sbjct: 59 RTVKAGTLEKLVEHLVPA-FQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTA 117
Query: 145 -------------ESHPTDELERTTEVAISVLSTWLASHPEDF 174
+ P D+L+ S+L TWL + EDF
Sbjct: 118 SSRYGCILPYSDEDGGPQDQLKNAIS---SILGTWLDQYSEDF 157
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 355 bits (911), Expect = 9e-98
Identities = 258/758 (34%), Positives = 383/758 (50%), Gaps = 107/758 (14%)
Query: 51 EEAPVSVWDEE-EDGAVFTVTSRQYR-------------------PLDPLVPMPPPRSSR 90
EE+ + W EE E+GAV+ VT ++ + P V R
Sbjct: 43 EESSIQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQYETCKIR 102
Query: 91 RLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALES---- 146
++AGTLE LV +LL T D +++S FL+T+R F ST +L L+ DR L S
Sbjct: 103 TIKAGTLEKLVENLL-TAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCE 161
Query: 147 ----HPTDELERTTEVAI-SVLSTWLASHPEDFGSEAKGQ-LDRLESFLLQTGYAAGKGV 200
+ E + AI S+L WL EDF L +L +L T G
Sbjct: 162 EDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYL--TRMMPGSDP 219
Query: 201 GGGSADLIRNLRSRVDPQAPDLPKPLALPGDPP-----ADPTDVLVFLADHLAEQLTLLD 255
+ +L+ + + LP ++ + + + F D +AEQLT +D
Sbjct: 220 ERRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTYMD 279
Query: 256 AELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGP 315
A+LF ++P CLG +W RD+ + HL P++RAT++QFN + VVS++LG
Sbjct: 280 AQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTILGG------- 332
Query: 316 GEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATR 375
+ L+ QRA+++EKWI +A ECRLL+NFSS+ A+VSALQS+ I+RL+ W R
Sbjct: 333 -----KELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPR 387
Query: 376 DSLRVFSSLCQIFSEEDNYSQSRELLVQE-----VKLQSPLEPHSKKAPR----SGSRG- 425
D + +F L IFS+ +N+ SRELL++E L S ++ + K+ R G
Sbjct: 388 DRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGV 447
Query: 426 -GGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQP 484
G VPYLGTFL DL MLD A +D +E G INF+KRR+EF V+++++ LQ+ C Y + P
Sbjct: 448 MQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMTP 507
Query: 485 DHDIQRWLQGLRPLTEAQSHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGS--VGV 542
D +W Q + LTE +S+ +SCE+E + +P+ R ++V LGS +
Sbjct: 508 DQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSPKP-RKSMVKRLSLLFLGSDMITS 566
Query: 543 PTP---------------------LVSCDRPSTGGDEAPTTPA-----PLLTRLAQHMKW 576
PTP + SC+ + +E TP P
Sbjct: 567 PTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPMDTPDEPQKKLSESSSSC 626
Query: 577 PSVSSLDSALESSPSLHSPADPSHLSPPASSPRPSRGHRRSASCGSPLSGGAEEASGGTG 636
S+ S+D+ SL +P SPP+ + P + H+RS S S S
Sbjct: 627 SSIHSMDTNSSGMSSLINPLS----SPPSCNNNP-KIHKRSVSVTSITSTVLPPV----- 676
Query: 637 YGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISRVLKKNNRDSAVASE 696
Y + D IIR+ +E +G++YKSI++TSQDK P+VI R + K+N DS A E
Sbjct: 677 YNQQNE-----DTCIIRISVE-DNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDPAEE 730
Query: 697 YELVQLLPGERELTIPASANVFYAMDG-ASHDFLLRQR 733
YELVQ++ ++EL IP SANVFYAM+ + DF+LR++
Sbjct: 731 YELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKK 768
>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
[Homo sapiens]
Length = 473
Score = 171 bits (434), Expect = 2e-42
Identities = 105/303 (34%), Positives = 165/303 (54%), Gaps = 25/303 (8%)
Query: 215 VDPQ-APDLPKPL--ALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGL 271
++PQ AP+ P ++ P + D+ F LAEQLTL+DAELF ++ +CLG +
Sbjct: 188 LEPQSAPESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCI 247
Query: 272 WGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARL 331
WG G+ H+ P+VRAT+ FN++ + +S LG S +R RAR+
Sbjct: 248 WGQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHS------------MRARDRARV 295
Query: 332 LEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEE 391
+E WI+VA EC L NFSSV+ +VSAL S+PI +L W + S++ LC +
Sbjct: 296 VEHWIKVARECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELC-----K 350
Query: 392 DNYSQSRELLVQ--EVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDE 449
+ + R+LL++ K+ + + R + GVVP+LG FL +L LD+A D+
Sbjct: 351 KDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGVVPFLGDFLTELQRLDSAIPDD 410
Query: 450 LENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCE 509
L+ N +KR KE VL E++ LQ Y L+P + + L++ +S+++SC+
Sbjct: 411 LDG---NTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQ 467
Query: 510 VEP 512
+EP
Sbjct: 468 LEP 470
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 102 bits (255), Expect = 1e-21
Identities = 110/473 (23%), Positives = 200/473 (42%), Gaps = 93/473 (19%)
Query: 92 LRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTD- 150
++ GT+ L+ L T D +F+ FL T+R+F LL L+ +R E E PTD
Sbjct: 599 IKGGTVVKLIERL--TYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTDA 656
Query: 151 --------------ELERTTEV--------AISVLSTWLASHPEDFGSEAKGQLDRLESF 188
+L+R + ++V W+ H DF + + L+RLESF
Sbjct: 657 DKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLE-LLERLESF 715
Query: 189 LLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPA-----------DPT 237
+ GK + + + +R + QA + + PP +
Sbjct: 716 I---SSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETF 772
Query: 238 DVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKV 297
D++ +A QLTLL+++L+ + PS+ +G +W D+ +S P++ + +
Sbjct: 773 DLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINS---PNLLKMIRHTTNL 829
Query: 298 AGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSA 357
++ A + E R +L + I + + + L NF+ V +VSA
Sbjct: 830 TLWFEKCIVEAENFEE--------------RVAVLSRIIEILQVFQDLNNFNGVLEIVSA 875
Query: 358 LQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKK 417
+ S ++RL + T ++L+ + R++L + V+L + H KK
Sbjct: 876 VNSVSVYRL-----DHTFEALQ---------------ERKRKILDEAVELS---QDHFKK 912
Query: 418 -APRSGSRGGGVVPYLGTFLKDLVMLDAASKDELE---NGYINFDKRRKEFAVLSELRRL 473
+ S VP+ G +L +++ + + D L+ INF KRRK + E+++
Sbjct: 913 YLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQY 972
Query: 474 QNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRV-------SCEVEPPGSSDPP 519
QN+ Y L+ + D++R+ + L P+ A S E+EP PP
Sbjct: 973 QNQ--PYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPP 1023
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 102 bits (254), Expect = 1e-21
Identities = 111/413 (26%), Positives = 177/413 (42%), Gaps = 71/413 (17%)
Query: 238 DVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKV 297
DVL + A Q+TL+D +F + P + W +++ HS L P+V A +FN+V
Sbjct: 45 DVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEK--HS-LAPNVVAFTRRFNQV 101
Query: 298 AGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSA 357
+ VV +L A + RA +L ++++A++ L N S+ +VVSA
Sbjct: 102 SFWVVREILTAQTL--------------KIRAEILSHFVKIAKKLLELNNLHSLMSVVSA 147
Query: 358 LQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKK 417
LQS+PI RL W R F L + S+EDNY ++RE + + S
Sbjct: 148 LQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPS-------- 199
Query: 418 APRSGSRGGGVVPYLGTFLKDLVMLDA---ASKDELENGYINFDKRRKEF-AVLSELRRL 473
+PYLG +L DL+ +D+ AS +EN ++R + +L + L
Sbjct: 200 -----------IPYLGIYLLDLIYIDSAYPASGSIMEN-----EQRSNQMNNILRIIADL 243
Query: 474 QNECRGYNLQPDHDIQRWLQGLRPLTEAQ------SHRVSCEVEPPGSSDPPAPRVLRPT 527
Q C +L +Q++L+ +R + E Q ++++S +EP SS P
Sbjct: 244 QVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSS---------PR 294
Query: 528 LVISQWTEVLGSVGVPTPLVS----CDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLD 583
LV S+ S G + S C S G PT P P H ++
Sbjct: 295 LVSSKEDLAGPSAGSGSARFSRRPTCPDTSVAG-SLPTPPVP--RHRKSHSLGNNMMCQL 351
Query: 584 SALESSPSLHSPADPSHLSP----PASSPRPSRGHRRSASCGSPLSGGAEEAS 632
S +ES + HL + SPR S++ + LS G+ E+S
Sbjct: 352 SVVESKSATFPSEKARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESS 404
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 100 bits (250), Expect = 4e-21
Identities = 142/613 (23%), Positives = 244/613 (39%), Gaps = 128/613 (20%)
Query: 43 QEEEEEEEEEAPVSVW----DEEEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLE 98
QEE+EE+ V+ + E+ +F M P ++AGT+
Sbjct: 560 QEEKEEQMRLPSADVYRFAEPDSEENIIFEEN------------MQPKAGIPIIKAGTVI 607
Query: 99 ALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALESHPTD-------- 150
L+ L T D +F+ FL T+R+F LL L+ +R E E PT+
Sbjct: 608 KLIERL--TYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIEN 665
Query: 151 -------ELERTTE-----VAISVLST---WLASHPEDFGSEAKGQLDRLESFLLQTGYA 195
EL+R + V + VL+ W+ H DF +A L R+E F+ G
Sbjct: 666 GDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAY-LLQRMEEFI---GTV 721
Query: 196 AGKGVGGGSADLIRNLRSRVDPQAPDLPKPLALPGDPPA-----------DPTDVLVFLA 244
GK + + + ++ + + + PP + D+L
Sbjct: 722 RGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHP 781
Query: 245 DHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHS-HLCPSVRATVTQFNKVAGAVVS 303
+A QLTLL+++L+ + PS+ +G +W D+ +S +L +R T +V
Sbjct: 782 IEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVE 841
Query: 304 SVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPI 363
+ +R ++ + I + + + L NF+ V VVSA+ SSP+
Sbjct: 842 TE------------------NLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPV 883
Query: 364 HRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGS 423
+RL + + ++ ++ ED+Y + KL+S P
Sbjct: 884 YRLDHTFEQIPSRQKKILEEAHEL--SEDHYKK------YLAKLRSINPP---------- 925
Query: 424 RGGGVVPYLGTFLKDLVMLDAASKDELE---NGYINFDKRRKEFAVLSELRRLQNECRGY 480
VP+ G +L +++ + + + L+ INF KRRK + E+++ QN+ Y
Sbjct: 926 ----CVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQ--PY 979
Query: 481 NLQPDHDIQRWLQGLRPLTEAQSHRV-------SCEVEPPGSSDPPAPRVLRPTLVISQW 533
L+ + DI+R+ + L P+ + S E+EP + P PR + ++
Sbjct: 980 CLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEP--RNPKPLPRFPK------KY 1031
Query: 534 TEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMKWPSVSSLDSALESSPSLH 593
+ L S GV S RP T P P R + + P S +S + S
Sbjct: 1032 SYPLKSPGVRP---SNPRPGTMRHPTPLQQEP---RKISYSRIPE-SETESTASAPNSPR 1084
Query: 594 SPADPSHLSPPAS 606
+P P PPAS
Sbjct: 1085 TPLTP----PPAS 1093
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 97.4 bits (241), Expect = 4e-20
Identities = 67/241 (27%), Positives = 106/241 (43%), Gaps = 37/241 (15%)
Query: 244 ADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVS 303
A LAEQ+TLLD +F ++ + LG W D+ + P + T FN ++ V S
Sbjct: 1003 AMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDK---NERTPYIMKTSQHFNDMSNLVAS 1059
Query: 304 SVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPI 363
++ RA +EKW+ VA+ CR L N++ V + SAL S I
Sbjct: 1060 QIMNYADVSS--------------RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAI 1105
Query: 364 HRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGS 423
+RL+ W + ++ + + L + S E + RE L K +P
Sbjct: 1106 YRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETL----KNCNP------------- 1148
Query: 424 RGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQ 483
VPYLG +L DL ++ + + E G +NF K R ++ E+R+ Q + Q
Sbjct: 1149 ---PAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQ 1205
Query: 484 P 484
P
Sbjct: 1206 P 1206
Score = 33.5 bits (75), Expect = 0.77
Identities = 17/49 (34%), Positives = 29/49 (59%), Gaps = 2/49 (4%)
Query: 91 RLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMAD 139
++R ++E L+ L D R D F++ FL T+R FT+ +LG ++D
Sbjct: 638 QIRYASVERLLERLTDLRFLSID--FLNTFLHTYRIFTTAAVVLGKLSD 684
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 97.1 bits (240), Expect = 6e-20
Identities = 118/464 (25%), Positives = 191/464 (41%), Gaps = 56/464 (12%)
Query: 92 LRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLG----LMADRLEALESH 147
L +G+LEAL+ HL+ T D +++ FL + R F LL + ++ + LE+
Sbjct: 45 LISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAG 104
Query: 148 PTD-ELERTTEVAISVLSTWLASHPEDFGSE-AKGQLDRLESFLLQTGYAAG---KGVGG 202
P +L+ + + +L W + P DF E A +L + + Q G K +
Sbjct: 105 PEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQ 164
Query: 203 GSADLIRNLRSRVDPQA-------PDLPKPLALPGDPPADPTDVLVFLADHL--AEQLTL 253
+ L+ +L +R Q P + K L PPA D+L D L A+QLT
Sbjct: 165 MTQSLLLSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTH 224
Query: 254 LDAELFLNLIPSQCL------GGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLG 307
++ + ++ P + L HR R G S+ A FN ++ V + V
Sbjct: 225 IELDRVSSIYPEDLMQIVSHMDSLDNHRCR-GDLTKTYSLEAYDNWFNCLSMLVATEVC- 282
Query: 308 ATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLR 367
R ++ R R+LE +I VA EC + NF+S+ A++S + SP+ RL+
Sbjct: 283 -------------RVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLK 329
Query: 368 AAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGG 427
W + V S NY + + Q ++ + SR
Sbjct: 330 KTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQM------------ANSSREKI 377
Query: 428 VVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSE-LRRLQNECRGYNLQPDH 486
V+P F+KD+ L + L NG+INF K + + E + Q EC + D
Sbjct: 378 VIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQVEC---PFEKDK 434
Query: 487 DIQRWLQGLRPLTEAQSHRVSCEVE-PPGSSDPPAPRVLRPTLV 529
IQ +L +E S E E P + + + LR TL+
Sbjct: 435 KIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLL 478
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 90.9 bits (224), Expect = 4e-18
Identities = 99/411 (24%), Positives = 173/411 (42%), Gaps = 67/411 (16%)
Query: 238 DVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKV 297
DVL + A Q+TL+D +F + P + W +++ + P+ A +FN V
Sbjct: 44 DVLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSA---PNAVAFTRRFNHV 100
Query: 298 AGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSA 357
+ VV +L A + RA +L +I+ A++ L N ++ AVVS
Sbjct: 101 SFWVVREILHAQTL--------------KIRAEVLSHYIKTAKKLYELNNLHALMAVVSG 146
Query: 358 LQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKK 417
LQS+PI RL W +R F L + S+EDNY + R+ +
Sbjct: 147 LQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYI---------------- 190
Query: 418 APRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFA--VLSELRRLQN 475
S + +PYLG +L DL +D+A G I +++R +L + LQ
Sbjct: 191 ---SSLKMTPCIPYLGIYLSDLTYIDSAYP---STGSILENEQRSNLMNNILRIISDLQQ 244
Query: 476 ECRGYNLQPDHDIQRWLQGLRPLTEAQ------SHRVSCEVEPPGSSDPPAPRVLRPTLV 529
C Y++ +Q++L ++ + E Q ++++S ++E PG+S P +
Sbjct: 245 SCE-YDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIE-PGTSTPRS--------- 293
Query: 530 ISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTP------APLLTRLAQHMKWPSVSSLD 583
+ +++G +P + G P TP P R + + + ++
Sbjct: 294 AASREDLVGPEVGASPQSGRKSVAAEGALLPQTPPSPRNLIPHGHRKCHSLGYNFIHKMN 353
Query: 584 SALESSPSLHSPADPSHLSPPA--SSPRPSRGHRRSASCGSPLSGGAEEAS 632
+A E + A P HL + PSRG S++ S +S G+ + S
Sbjct: 354 TA-EFKSATFPNAGPRHLLDDSVMEPHAPSRGQAESSTLSSGISIGSSDGS 403
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 89.7 bits (221), Expect = 9e-18
Identities = 132/532 (24%), Positives = 215/532 (40%), Gaps = 88/532 (16%)
Query: 10 LDTSPPGGVVLSSFRSRDPEEGGG----PGGLVVGGGQEEEEEEEEEAPVSVWDEEEDGA 65
LDTS V SSF ++ P+EG P Q E EE+ + ++ +DG
Sbjct: 781 LDTSKL--YVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDIDQ-NQSDDGD 837
Query: 66 VFTVTSRQYRPLDPLVPMPPPRSSRRLRA---GTLEALVRHLLDTRTSGTDVSFMSAF-L 121
T TS P P S L + G + R L + R++ +S SAF +
Sbjct: 838 --TETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSA---LSAASAFAI 892
Query: 122 ATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAI---------SVLSTWLASHPE 172
AT A TP L A P D+ E I +VL W++ H +
Sbjct: 893 ATAGANEGTPNKEKYRRMSL-ASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQ 951
Query: 173 DFGSEAK------GQLDRL---ESFLLQTGYAAGKGVGGGSADLIRNLRSRVDP--QAPD 221
DF + + G L+ + L Q AA A++IR L ++ DP
Sbjct: 952 DFETNDELKCKVIGFLEEVMHDPELLTQERKAA--------ANIIRTL-TQEDPGDNQIT 1002
Query: 222 LPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHS 281
L + + A+P + L +AEQLTLLD +F + + G W ++ +
Sbjct: 1003 LEEITQMAEGVKAEPFENHSAL--EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK---N 1057
Query: 282 HLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEE 341
P + T FN ++ + S + IR R +EKW+ VA+
Sbjct: 1058 ERTPYIMKTTKHFNDISNLIASEI--------------IRNEDINARVSAIEKWVAVADI 1103
Query: 342 CRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELL 401
CR L N+++V + S++ S I RL+ W + ++ + + L ++ S E + RE L
Sbjct: 1104 CRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREAL 1163
Query: 402 VQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRR 461
K P VPYLG +L DL ++ + + E+G +NF K R
Sbjct: 1164 ----KNCDP----------------PCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1203
Query: 462 KEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQS-HRVSCEVEP 512
++ E+R+ Q Y ++ + ++L + + +S + S +EP
Sbjct: 1204 MISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEP 1253
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 89.7 bits (221), Expect = 9e-18
Identities = 132/532 (24%), Positives = 215/532 (40%), Gaps = 88/532 (16%)
Query: 10 LDTSPPGGVVLSSFRSRDPEEGGG----PGGLVVGGGQEEEEEEEEEAPVSVWDEEEDGA 65
LDTS V SSF ++ P+EG P Q E EE+ + ++ +DG
Sbjct: 797 LDTSKL--YVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDIDQ-NQSDDGD 853
Query: 66 VFTVTSRQYRPLDPLVPMPPPRSSRRLRA---GTLEALVRHLLDTRTSGTDVSFMSAF-L 121
T TS P P S L + G + R L + R++ +S SAF +
Sbjct: 854 --TETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSA---LSAASAFAI 908
Query: 122 ATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAI---------SVLSTWLASHPE 172
AT A TP L A P D+ E I +VL W++ H +
Sbjct: 909 ATAGANEGTPNKEKYRRMSL-ASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQ 967
Query: 173 DFGSEAK------GQLDRL---ESFLLQTGYAAGKGVGGGSADLIRNLRSRVDP--QAPD 221
DF + + G L+ + L Q AA A++IR L ++ DP
Sbjct: 968 DFETNDELKCKVIGFLEEVMHDPELLTQERKAA--------ANIIRTL-TQEDPGDNQIT 1018
Query: 222 LPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHS 281
L + + A+P + L +AEQLTLLD +F + + G W ++ +
Sbjct: 1019 LEEITQMAEGVKAEPFENHSAL--EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK---N 1073
Query: 282 HLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEE 341
P + T FN ++ + S + IR R +EKW+ VA+
Sbjct: 1074 ERTPYIMKTTKHFNDISNLIASEI--------------IRNEDINARVSAIEKWVAVADI 1119
Query: 342 CRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELL 401
CR L N+++V + S++ S I RL+ W + ++ + + L ++ S E + RE L
Sbjct: 1120 CRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREAL 1179
Query: 402 VQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRR 461
K P VPYLG +L DL ++ + + E+G +NF K R
Sbjct: 1180 ----KNCDP----------------PCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 1219
Query: 462 KEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQS-HRVSCEVEP 512
++ E+R+ Q Y ++ + ++L + + +S + S +EP
Sbjct: 1220 MISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEP 1269
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 89.7 bits (221), Expect = 9e-18
Identities = 132/532 (24%), Positives = 215/532 (40%), Gaps = 88/532 (16%)
Query: 10 LDTSPPGGVVLSSFRSRDPEEGGG----PGGLVVGGGQEEEEEEEEEAPVSVWDEEEDGA 65
LDTS V SSF ++ P+EG P Q E EE+ + ++ +DG
Sbjct: 13 LDTSKL--YVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDIDQ-NQSDDGD 69
Query: 66 VFTVTSRQYRPLDPLVPMPPPRSSRRLRA---GTLEALVRHLLDTRTSGTDVSFMSAF-L 121
T TS P P S L + G + R L + R++ +S SAF +
Sbjct: 70 --TETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSA---LSAASAFAI 124
Query: 122 ATHRAFTSTPALLGLMADRLEALESHPTDELERTTEVAI---------SVLSTWLASHPE 172
AT A TP L A P D+ E I +VL W++ H +
Sbjct: 125 ATAGANEGTPNKEKYRRMSL-ASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQ 183
Query: 173 DFGSEAK------GQLDRL---ESFLLQTGYAAGKGVGGGSADLIRNLRSRVDP--QAPD 221
DF + + G L+ + L Q AA A++IR L ++ DP
Sbjct: 184 DFETNDELKCKVIGFLEEVMHDPELLTQERKAA--------ANIIRTL-TQEDPGDNQIT 234
Query: 222 LPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHS 281
L + + A+P + L +AEQLTLLD +F + + G W ++ +
Sbjct: 235 LEEITQMAEGVKAEPFENHSAL--EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK---N 289
Query: 282 HLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEE 341
P + T FN ++ + S + IR R +EKW+ VA+
Sbjct: 290 ERTPYIMKTTKHFNDISNLIASEI--------------IRNEDINARVSAIEKWVAVADI 335
Query: 342 CRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELL 401
CR L N+++V + S++ S I RL+ W + ++ + + L ++ S E + RE L
Sbjct: 336 CRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREAL 395
Query: 402 VQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRR 461
K P VPYLG +L DL ++ + + E+G +NF K R
Sbjct: 396 ----KNCDP----------------PCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMR 435
Query: 462 KEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQS-HRVSCEVEP 512
++ E+R+ Q Y ++ + ++L + + +S + S +EP
Sbjct: 436 MISHIIREIRQFQQ--TAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEP 485
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 89.0 bits (219), Expect = 2e-17
Identities = 126/508 (24%), Positives = 199/508 (39%), Gaps = 73/508 (14%)
Query: 14 PPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDEEEDGAVFTVTSRQ 73
PP G RDP G G G E + + A S EEE + + +
Sbjct: 638 PPAG---KDGHPRDPSAVSGVPGKDSRDGSERAPKSPD-ALESAQSEEEVDELSLIDHNE 693
Query: 74 YRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPAL 133
+ L +R G+ + L+ H +T V + AFL T+R F S L
Sbjct: 694 I--MSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDL-VLYCEAFLTTYRTFISPEEL 750
Query: 134 LGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKGQLDRLESFLLQTG 193
+ + R E +R ++ VL + + ++ E L
Sbjct: 751 IKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVV---------DELCLVELTEEILKLLM 801
Query: 194 YAAGKGVGGGSADLIRNLRS----RVDPQ----APDLPKPLALPGDPPADPTDVLVFLAD 245
+ V G L R LR +VD + +PLA G A P + F +
Sbjct: 802 ELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARG-VAARPGTLHDFHSH 860
Query: 246 HLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSV 305
+AEQLTLLDAELF + + L LW S P++ FN ++ V S +
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKS---PNLTQFTEHFNNMSYWVRSII 915
Query: 306 LGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHR 365
+ + R RLL K+I++ + R L NF+S A++SAL S+PI R
Sbjct: 916 MLQEKAQD--------------RERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 961
Query: 366 LRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRG 425
L W + T + L + C + ++ R L S +EP
Sbjct: 962 LE--WQKQTSEGL---AEYCTLIDSSSSFRAYRAAL-------SEVEP------------ 997
Query: 426 GGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPD 485
+PYLG L+DL + + D ++ G +NF KR ++F +L +R Q Y+++ +
Sbjct: 998 -PCIPYLGLILQDLTFVHLGNPDYID-GKVNFSKRWQQFNILDSMRCFQQ--AHYDMRRN 1053
Query: 486 HDIQRWLQGLRP-LTEAQSHRVSCEVEP 512
DI + L E +S +++P
Sbjct: 1054 DDIINFFNDFSDHLAEEALWELSLKIKP 1081
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 89.0 bits (219), Expect = 2e-17
Identities = 126/508 (24%), Positives = 199/508 (39%), Gaps = 73/508 (14%)
Query: 14 PPGGVVLSSFRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDEEEDGAVFTVTSRQ 73
PP G RDP G G G E + + A S EEE + + +
Sbjct: 620 PPAG---KDGHPRDPSAVSGVPGKDSRDGSERAPKSPD-ALESAQSEEEVDELSLIDHNE 675
Query: 74 YRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPAL 133
+ L +R G+ + L+ H +T V + AFL T+R F S L
Sbjct: 676 I--MSRLTLKQEGDDGPDVRGGSGDILLVHATETDRKDL-VLYCEAFLTTYRTFISPEEL 732
Query: 134 LGLMADRLEALESHPTDELERTTEVAISVLSTWLASHPEDFGSEAKGQLDRLESFLLQTG 193
+ + R E +R ++ VL + + ++ E L
Sbjct: 733 IKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVV---------DELCLVELTEEILKLLM 783
Query: 194 YAAGKGVGGGSADLIRNLRS----RVDPQ----APDLPKPLALPGDPPADPTDVLVFLAD 245
+ V G L R LR +VD + +PLA G A P + F +
Sbjct: 784 ELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARG-VAARPGTLHDFHSH 842
Query: 246 HLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSV 305
+AEQLTLLDAELF + + L LW S P++ FN ++ V S +
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKS---PNLTQFTEHFNNMSYWVRSII 897
Query: 306 LGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHR 365
+ + R RLL K+I++ + R L NF+S A++SAL S+PI R
Sbjct: 898 MLQEKAQD--------------RERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRR 943
Query: 366 LRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRG 425
L W + T + L + C + ++ R L S +EP
Sbjct: 944 LE--WQKQTSEGL---AEYCTLIDSSSSFRAYRAAL-------SEVEP------------ 979
Query: 426 GGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPD 485
+PYLG L+DL + + D ++ G +NF KR ++F +L +R Q Y+++ +
Sbjct: 980 -PCIPYLGLILQDLTFVHLGNPDYID-GKVNFSKRWQQFNILDSMRCFQQ--AHYDMRRN 1035
Query: 486 HDIQRWLQGLRP-LTEAQSHRVSCEVEP 512
DI + L E +S +++P
Sbjct: 1036 DDIINFFNDFSDHLAEEALWELSLKIKP 1063
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 85.5 bits (210), Expect = 2e-16
Identities = 112/451 (24%), Positives = 186/451 (41%), Gaps = 64/451 (14%)
Query: 92 LRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALE--SHPT 149
L +G+LEAL++HL+ D +++ FL + R F L+ + + S P
Sbjct: 38 LLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPD 97
Query: 150 DELERTTEVA---ISVLSTWLASHPEDFGSEA-----KGQLDRLESFLLQTGYAAGKGVG 201
+ + ++A + +L+ W + P DF E K R+ S QT K V
Sbjct: 98 SDKNQMRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEQT---YRKNVQ 154
Query: 202 GGSADLIRNLRS---------RVDPQAPDLPKPLALPGDPPADPTDVLVFLADH--LAEQ 250
LIR L + ++ + D + L P + D++ D LA+Q
Sbjct: 155 QMMQCLIRKLAALSQYEEVLAKISSTSTD--RLTVLKTKPQSIQRDIITVCNDPYTLAQQ 212
Query: 251 LTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVR-------ATVTQFNKVAGAVVS 303
LT ++ E LN I + + +D + C S R A V FN+++ V +
Sbjct: 213 LTHIELER-LNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVAT 271
Query: 304 SVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPI 363
+ P++ RAR++E +I VA EC + NF+S+ A++S + SP+
Sbjct: 272 EIC--------------MPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPV 317
Query: 364 HRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGS 423
RL+ W + F L N+ R L Q L HS S
Sbjct: 318 SRLKKTWAKV---KTAKFDILEHQMDPSSNFYNYRTAL--RGAAQRSLTAHS-------S 365
Query: 424 RGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSE-LRRLQNECRGYNL 482
R V+P+ +KD+ L+ + L NG++NF+K + +SE + Q EC
Sbjct: 366 REKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC---PF 422
Query: 483 QPDHDIQRWLQGLRPLTEAQSHRVSCEVEPP 513
+ D I ++L + +E + S E E P
Sbjct: 423 ERDRKILQYLLTVPVFSEDALYLASYESEGP 453
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 81.3 bits (199), Expect = 3e-15
Identities = 86/318 (27%), Positives = 135/318 (42%), Gaps = 57/318 (17%)
Query: 166 WLASHPEDFGSEAKGQ--LDRLESFLLQTGYAAGKGVGGGSADLIRNLRSRVDPQAPDLP 223
WL HPE + + + + R + + + G +A + +G S+DL+ P P P
Sbjct: 128 WLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGD-SSDLL-------SPGGPGPP 179
Query: 224 KPLALPGDPPADPTDVLVFLADHL-----AEQLTLLDAELFLNLIPSQCLGGLWGHRDRP 278
P++ PG +L DHL A+ LT L+ F + P +
Sbjct: 180 LPMSSPGLGKKRKVSLLF---DHLETGELAQHLTYLEFRSFQAITPQDLRSYVL-----Q 231
Query: 279 GHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRV 338
G CP++ +V N V+ V VL PG P QRA++L+K+I V
Sbjct: 232 GSVRGCPALEGSVGLSNSVSRWVQVMVLSR------PG--------PLQRAQVLDKFIHV 277
Query: 339 AEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSR 398
A+ L+NF+++ AV L S I RL+ + + DS + L ++ + +NY++ R
Sbjct: 278 AQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYR 337
Query: 399 ELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFD 458
A +G R +P LG LKDLV L A D L +G ++
Sbjct: 338 RTW----------------AGCAGFR----LPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 377
Query: 459 KRRKEFAVLSELRRLQNE 476
K + L EL LQ +
Sbjct: 378 KLNNLYLRLQELVALQGQ 395
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 80.9 bits (198), Expect = 4e-15
Identities = 89/385 (23%), Positives = 160/385 (41%), Gaps = 49/385 (12%)
Query: 94 AGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMAD---RLEALESHPTD 150
+ +LE L++HL+ T + +++ FL + R F LL + + L+ D
Sbjct: 40 SASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLD 99
Query: 151 E--LERTTEVAISVLSTWLASHPEDFGSEAK-GQLDRLESFLLQTGYAAGKGVGGGSADL 207
+ + + + +L+ W + P DF E+ G L + + A K + L
Sbjct: 100 KARVRKFGPKLLQLLAEWTETFPRDFQEESTIGHLKDVVGRIAPCDEAYRKRMH----QL 155
Query: 208 IRNLRSRVDP--QAPD----LPKPLALPGDPPADPTDVLVFLADH---LAEQLTLLDAEL 258
++ L ++ Q P+ KP++ PPA L+ + LA+QLT ++ E
Sbjct: 156 LQALHQKLAALRQGPEGLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELER 215
Query: 259 FLNLIPSQCLGGLWGH----RDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEG 314
++ P + + +P S ++ A V FN++ V + +
Sbjct: 216 LRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVATEIC-------- 267
Query: 315 PGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEAT 374
P + QRA+++E +I VA EC + NF+S+ A++S + SP+ RL+ W +
Sbjct: 268 ------MPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVR 321
Query: 375 RDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGT 434
F L N+ R L L HS SR V+P+
Sbjct: 322 TAK---FFILEHQMDPTGNFCNYRTAL--RGAAHRSLTAHS-------SREKIVIPFFSL 369
Query: 435 FLKDLVMLDAASKDELENGYINFDK 459
+KD+ L+ + L NG++NF+K
Sbjct: 370 LIKDIYFLNEGCANRLPNGHVNFEK 394
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 78.6 bits (192), Expect = 2e-14
Identities = 62/225 (27%), Positives = 99/225 (44%), Gaps = 26/225 (11%)
Query: 325 PPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSL 384
P QRA ++ K+I VA++ L+NF+++ AVV L S I RL+ + + + ++ +
Sbjct: 215 PQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEM 274
Query: 385 CQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDA 444
++ S NY R+ G +P LG LKDL+ +
Sbjct: 275 TELVSSNGNYCNYRKAF--------------------ADCDGFKIPILGVHLKDLIAVHV 314
Query: 445 ASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPL--TEAQ 502
D E +N K + LSEL LQN ++L+P+ D+ L L TE
Sbjct: 315 IFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLDLYHTEDD 372
Query: 503 SHRVSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLV 547
+++S +EP S P +P +V +W LG + P P V
Sbjct: 373 IYKLSLVLEPRNSKSPTSPTTPNKPVVPLEW--ALGVMPKPDPTV 415
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 75.5 bits (184), Expect = 2e-13
Identities = 63/226 (27%), Positives = 100/226 (44%), Gaps = 27/226 (11%)
Query: 325 PPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSL 384
P QRA ++ K+I VA++ L+NF+++ AVV L S I RL+ + + + ++ +
Sbjct: 215 PQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEM 274
Query: 385 CQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDA 444
++ S NY R+ G +P LG LKDL+ +
Sbjct: 275 TELVSSNGNYCNYRKAF--------------------ADCDGFKIPILGVHLKDLIAVHV 314
Query: 445 ASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPL--TEAQ 502
D E +N K + LSEL LQN ++L+P+ D+ L L TE
Sbjct: 315 IFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLDLYHTEDD 372
Query: 503 SHRVSCEVEPPGS-SDPPAPRVLRPTLVISQWTEVLGSVGVPTPLV 547
+++S +EP S S P +P +V +W LG + P P V
Sbjct: 373 IYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEW--ALGVMPKPDPTV 416
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 75.5 bits (184), Expect = 2e-13
Identities = 63/226 (27%), Positives = 100/226 (44%), Gaps = 27/226 (11%)
Query: 325 PPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSL 384
P QRA ++ K+I VA++ L+NF+++ AVV L S I RL+ + + + ++ +
Sbjct: 215 PQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEM 274
Query: 385 CQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDA 444
++ S NY R+ G +P LG LKDL+ +
Sbjct: 275 TELVSSNGNYCNYRKAF--------------------ADCDGFKIPILGVHLKDLIAVHV 314
Query: 445 ASKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPL--TEAQ 502
D E +N K + LSEL LQN ++L+P+ D+ L L TE
Sbjct: 315 IFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLDLYHTEDD 372
Query: 503 SHRVSCEVEPPGS-SDPPAPRVLRPTLVISQWTEVLGSVGVPTPLV 547
+++S +EP S S P +P +V +W LG + P P V
Sbjct: 373 IYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEW--ALGVMPKPDPTV 416
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 70.5 bits (171), Expect = 6e-12
Identities = 65/230 (28%), Positives = 99/230 (43%), Gaps = 39/230 (16%)
Query: 247 LAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVL 306
LA+ LT L+ F + P + G CP++ +V N V+ V VL
Sbjct: 191 LAQHLTYLEFRSFQAITPQDLRSYVL-----QGSVRGCPALEGSVGLSNSVSRWVQVMVL 245
Query: 307 GATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRL 366
PG P QRA++L+K+I VA+ L+NF+++ AV L S I RL
Sbjct: 246 SR------PG--------PLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRL 291
Query: 367 RAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGG 426
+ + + DS + L ++ + +NY++ R A +G R
Sbjct: 292 KDSHAHLSPDSTKALLELTELLASHNNYARYRRTW----------------AGCAGFR-- 333
Query: 427 GVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSELRRLQNE 476
+P LG LKDLV L A D L +G ++ K + L EL LQ +
Sbjct: 334 --LPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQ 381
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 69.7 bits (169), Expect = 1e-11
Identities = 52/215 (24%), Positives = 98/215 (45%), Gaps = 37/215 (17%)
Query: 247 LAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVL 306
+A QL++ + ELF N+ P++ + L+ R + C +++ N+ V S +L
Sbjct: 721 VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTS----CANLKRFEEVINQETFWVASEIL 776
Query: 307 GATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRL 366
T+ +R ++++ +I++A CR +NF+S++A++S L +P+ RL
Sbjct: 777 RETNQ--------------LKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARL 822
Query: 367 RAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGG 426
R W + ++F L +F N ++ R +L + LQ P
Sbjct: 823 RTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQ-NLQPP---------------- 865
Query: 427 GVVPYLGTFLKDLVMLDAASKDELENGYINFDKRR 461
++P KDL L + D +G +NF+K R
Sbjct: 866 -IIPLFPVIKKDLTFLHEGN-DSKVDGLVNFEKLR 898
Score = 35.0 bits (79), Expect = 0.27
Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 17/115 (14%)
Query: 61 EEDGAVFTVTSRQYRPLDPLVPMPPPRSSRRLRAGTLEALVRHLLDTRTSGTDVSFMSAF 120
EE+G + V +++R LD R + GT E L HL++ S D +F+ F
Sbjct: 246 EEEGEIVMV--KEHRELD----RTGTRKGHIVIKGTSERLTMHLVEEH-SVVDPTFIEDF 298
Query: 121 LATHRAFTSTPALLGLMADRLEALESHPTDEL-ERTTEVAISVLSTWLASHPEDF 174
L T+R F S+P +G + LE L ++ T V + W+ +H DF
Sbjct: 299 LLTYRTFLSSPMEVG-----KKLLEWFNDPSLRDKVTRVVL----LWVNNHFNDF 344
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/214 (26%), Positives = 96/214 (44%), Gaps = 25/214 (11%)
Query: 326 PQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLC 385
PQRA ++ ++ VAE+ L+NF+++ AVV L S I RL+ + ++++++ L
Sbjct: 218 PQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLT 277
Query: 386 QIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAA 445
++ + NY R L V + P+ LG LKDLV L A
Sbjct: 278 ELVTATGNYGNYRRRLAACVGFRFPI--------------------LGVHLKDLVALQLA 317
Query: 446 SKDELE--NGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQS 503
D L+ +N K ++ F++L EL + + PD + + TE +
Sbjct: 318 LPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDEL 377
Query: 504 HRVSCEVEPPGSSDPPAPRVLRP---TLVISQWT 534
+++S + EP S P +P P V+ +WT
Sbjct: 378 YQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWT 411
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/214 (26%), Positives = 96/214 (44%), Gaps = 25/214 (11%)
Query: 326 PQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLC 385
PQRA ++ ++ VAE+ L+NF+++ AVV L S I RL+ + ++++++ L
Sbjct: 218 PQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLT 277
Query: 386 QIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAA 445
++ + NY R L V + P+ LG LKDLV L A
Sbjct: 278 ELVTATGNYGNYRRRLAACVGFRFPI--------------------LGVHLKDLVALQLA 317
Query: 446 SKDELE--NGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQS 503
D L+ +N K ++ F++L EL + + PD + + TE +
Sbjct: 318 LPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDEL 377
Query: 504 HRVSCEVEPPGSSDPPAPRVLRP---TLVISQWT 534
+++S + EP S P +P P V+ +WT
Sbjct: 378 YQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWT 411
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/214 (26%), Positives = 96/214 (44%), Gaps = 25/214 (11%)
Query: 326 PQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLC 385
PQRA ++ ++ VAE+ L+NF+++ AVV L S I RL+ + ++++++ L
Sbjct: 218 PQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLT 277
Query: 386 QIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAA 445
++ + NY R L V + P+ LG LKDLV L A
Sbjct: 278 ELVTATGNYGNYRRRLAACVGFRFPI--------------------LGVHLKDLVALQLA 317
Query: 446 SKDELE--NGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQS 503
D L+ +N K ++ F++L EL + + PD + + TE +
Sbjct: 318 LPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDEL 377
Query: 504 HRVSCEVEPPGSSDPPAPRVLRP---TLVISQWT 534
+++S + EP S P +P P V+ +WT
Sbjct: 378 YQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWT 411
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 66.2 bits (160), Expect = 1e-10
Identities = 47/152 (30%), Positives = 73/152 (48%), Gaps = 20/152 (13%)
Query: 325 PPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSL 384
P QRA++L+K+I VA+ L+NF+++ AV L S I RL+ + + DS + L
Sbjct: 230 PLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLEL 289
Query: 385 CQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDA 444
++ + +NY++ R A +G R +P LG LKDLV L
Sbjct: 290 TELLASHNNYARYRRTW----------------AGCAGFR----LPVLGVHLKDLVSLHE 329
Query: 445 ASKDELENGYINFDKRRKEFAVLSELRRLQNE 476
A D L +G ++ K + L EL LQ +
Sbjct: 330 AQPDRLPDGRLHLPKLNNLYLRLQELVALQGQ 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,811,507
Number of Sequences: 37866
Number of extensions: 2084435
Number of successful extensions: 16039
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 353
Number of HSP's that attempted gapping in prelim test: 14255
Number of HSP's gapped (non-prelim): 1748
length of query: 777
length of database: 18,247,518
effective HSP length: 110
effective length of query: 667
effective length of database: 14,082,258
effective search space: 9392866086
effective search space used: 9392866086
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.