Search of human proteins with 47519913

Search of human proteins with 47519913

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo
sapiens]
         (471 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   961   0.0  
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   691   0.0  
gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ...   447   e-125
gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2 [...   377   e-105
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   294   1e-79
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   294   1e-79
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   277   1e-74
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   210   3e-54
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   169   7e-42
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   168   1e-41
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    162   6e-40
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   162   8e-40
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   161   1e-39
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   159   7e-39
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   158   9e-39
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   158   1e-38
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   150   2e-36
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   148   9e-36
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     147   2e-35
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   146   5e-35
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   132   9e-31
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   130   3e-30
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   124   1e-28
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   119   6e-27
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   110   4e-24
gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]   105   9e-23
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              104   2e-22
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur...    80   4e-15
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]               76   6e-14
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom...    76   8e-14

>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  961 bits (2484), Expect = 0.0
 Identities = 471/471 (100%), Positives = 471/471 (100%)

Query: 1   MLAFILSRATPRPALGPLSYREHRVALLHLTHSMSTTGRGVTFTINCSGFGQHGADPTAL 60
           MLAFILSRATPRPALGPLSYREHRVALLHLTHSMSTTGRGVTFTINCSGFGQHGADPTAL
Sbjct: 1   MLAFILSRATPRPALGPLSYREHRVALLHLTHSMSTTGRGVTFTINCSGFGQHGADPTAL 60

Query: 61  NSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPE 120
           NSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPE
Sbjct: 61  NSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPE 120

Query: 121 ECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLD 180
           ECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLD
Sbjct: 121 ECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLD 180

Query: 181 IFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATA 240
           IFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATA
Sbjct: 181 IFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATA 240

Query: 241 KLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITL 300
           KLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITL
Sbjct: 241 KLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITL 300

Query: 301 LLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPR 360
           LLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPR
Sbjct: 301 LLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPR 360

Query: 361 WLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSE 420
           WLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSE
Sbjct: 361 WLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSE 420

Query: 421 WTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT 471
           WTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT
Sbjct: 421 WTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT 471


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  691 bits (1782), Expect = 0.0
 Identities = 334/446 (74%), Positives = 376/446 (84%), Gaps = 9/446 (2%)

Query: 26  ALLHLTHSMSTTGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISF 85
           ALL LT S+   GRG  FTINCSGF QHG DP    +VF+RK FRP TN S+PT+VNISF
Sbjct: 11  ALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISF 70

Query: 86  AMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIEL 145
            +SAIL V+ QL LL+SFLW+++VWDNPFI+WNP+EC GI K+++ A+NLWLPDIFI+E 
Sbjct: 71  TLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVES 130

Query: 146 MDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSM 205
           MDVD+TP GLTAY+S+EGRI+Y KPM+V SICNLDIFYFPFDQQNCT TFSSFLYTVDSM
Sbjct: 131 MDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSM 190

Query: 206 LLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLY 265
           LL M+KEVWEITD SR ++QT GEWELLG++KAT K+S G NLYDQI+FYVAIRRRPSLY
Sbjct: 191 LLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLY 250

Query: 266 VINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGV 325
           +INLLVPS FLVAIDALSFYLP +S NR PFKITLLLGYNVFLLMM+DLLP SGTPLI V
Sbjct: 251 IINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISV 310

Query: 326 YFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENK 385
           YFALCLSLMV SLLET+FIT+LLHVATTQPPP+PRWLHSLLLHC SPGRCCPTAPQK NK
Sbjct: 311 YFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNK 370

Query: 386 GPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHA 445
           G GLT THLPG KEP   AG+  GP E E  GGS WT+ Q          +ELW+QFSHA
Sbjct: 371 GLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQ---------LMELWVQFSHA 421

Query: 446 MDAMLFRLYLLFMASSIITVICLWNT 471
           MD +LFRLYLLFMASSI+TVI LWNT
Sbjct: 422 MDTLLFRLYLLFMASSILTVIVLWNT 447


>gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1
           [Homo sapiens]
          Length = 404

 Score =  447 bits (1150), Expect = e-125
 Identities = 248/414 (59%), Positives = 283/414 (68%), Gaps = 47/414 (11%)

Query: 83  ISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFI 142
           + F +  +L  +  L L++SFLWL M        WNP+EC GI K  MA +NLWL D+FI
Sbjct: 13  LGFILHLLLQ-DSHLQLVTSFLWLNM--------WNPDECGGIKKSGMATENLWLSDVFI 63

Query: 143 IELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFL--- 199
            E   VD+TP GL A +S       K      S C            N T + S  +   
Sbjct: 64  EE--SVDQTPAGLMASMSI-----VKATSNTISQCGWSA------SANWTPSISPSMDRG 110

Query: 200 -YTVDSMLLDMEKEVWEITDAS-----RNILQTHGEWELLGLSKATAKLSRGGNLYDQIV 253
             +  ++        W     S     R   +T  EW LLG+ K T K++   N Y+Q +
Sbjct: 111 ERSPSALSPTQVTRAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAI 170

Query: 254 FYVAIRRR--PSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMM 311
           F+VAIRRR  PS YV+N LVPSG L+AIDALSFYLP++SGN  PFK+T+LLGY+VFLLMM
Sbjct: 171 FHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMM 230

Query: 312 SDLLPTSGTP----LI----------GVYFALCLSLMVGSLLETIFITHLLHVATTQPPP 357
           +DLLP + T     L+          GVYFALCLSLMVGSLLETIFITHLLHVATTQP P
Sbjct: 231 NDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLP 290

Query: 358 LPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTG 417
           LPRWLHSLLLHC   GRCCPTAPQK NKGPGLTPTHLPGVKEPEVSAGQMPGP EAELTG
Sbjct: 291 LPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTG 350

Query: 418 GSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT 471
           GSEWTRAQREHEAQKQHSVELW+QFSHAMDA+LFRLYLLFMASSIITVICLWNT
Sbjct: 351 GSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 404


>gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2
           [Homo sapiens]
          Length = 279

 Score =  377 bits (969), Expect = e-105
 Identities = 190/232 (81%), Positives = 202/232 (87%), Gaps = 16/232 (6%)

Query: 256 VAIRRR--PSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSD 313
           VAIRRR  PS YV+N LVPSG L+AIDALSFYLP++SGN  PFK+T+LLGY+VFLLMM+D
Sbjct: 48  VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMND 107

Query: 314 LLPTSGTP----LI----------GVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLP 359
           LLP + T     L+          GVYFALCLSLMVGSLLETIFITHLLHVATTQP PLP
Sbjct: 108 LLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLP 167

Query: 360 RWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGS 419
           RWLHSLLLHC   GRCCPTAPQK NKGPGLTPTHLPGVKEPEVSAGQMPGP EAELTGGS
Sbjct: 168 RWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGS 227

Query: 420 EWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT 471
           EWTRAQREHEAQKQHSVELW+QFSHAMDA+LFRLYLLFMASSIITVICLWNT
Sbjct: 228 EWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 279


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  294 bits (752), Expect = 1e-79
 Identities = 169/433 (39%), Positives = 254/433 (58%), Gaps = 33/433 (7%)

Query: 66  RKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGI 125
           RK  RPV +   PT V+I   + AIL+V+E+  +L++++W    W + F+ WNPE+ + I
Sbjct: 52  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 111

Query: 126 TKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185
           TK+S+   ++W+PDI I E +DV K+P     Y+ ++G ++  KP++V + C+LDI+ FP
Sbjct: 112 TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 171

Query: 186 FDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITD---ASRNILQTHGEWELLGLSKATAKL 242
           FD QNC+LTF+S+L+T+     D+   +W + +   + R++    GEWELLG+     + 
Sbjct: 172 FDVQNCSLTFTSWLHTIQ----DINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 227

Query: 243 S-RGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLL 301
           S    N Y ++ FYV IRRRP  YV++LL+PS FL+ +D + FYLP  SG RV FKITLL
Sbjct: 228 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 287

Query: 302 LGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLP 359
           LGY+VFL+++SD LP +  GTPLIGVYF +C++L+V SL ETIFI  L+H    Q  P+P
Sbjct: 288 LGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQ-QPVP 346

Query: 360 RWLHSLLLHCNSPGRCC--------PTAPQKENK-----GPGLTPTHLPG----VKEPEV 402
            WL  L+L   +   C         P A  +  K       G   +H+ G     K P  
Sbjct: 347 AWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD 406

Query: 403 SAGQMPGPAEAELT--GGSEWTRAQREHEAQKQHSVEL---WLQFSHAMDAMLFRLYLLF 457
                P P EA L   G  +   + R+   ++    E+   WL+    +D +LF +YLL 
Sbjct: 407 RCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 466

Query: 458 MASSIITVICLWN 470
           + +  IT++ LW+
Sbjct: 467 VLAYSITLVMLWS 479


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  294 bits (752), Expect = 1e-79
 Identities = 169/433 (39%), Positives = 254/433 (58%), Gaps = 33/433 (7%)

Query: 66  RKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGI 125
           RK  RPV +   PT V+I   + AIL+V+E+  +L++++W    W + F+ WNPE+ + I
Sbjct: 31  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 90

Query: 126 TKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185
           TK+S+   ++W+PDI I E +DV K+P     Y+ ++G ++  KP++V + C+LDI+ FP
Sbjct: 91  TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 150

Query: 186 FDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITD---ASRNILQTHGEWELLGLSKATAKL 242
           FD QNC+LTF+S+L+T+     D+   +W + +   + R++    GEWELLG+     + 
Sbjct: 151 FDVQNCSLTFTSWLHTIQ----DINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 206

Query: 243 S-RGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLL 301
           S    N Y ++ FYV IRRRP  YV++LL+PS FL+ +D + FYLP  SG RV FKITLL
Sbjct: 207 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 266

Query: 302 LGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLP 359
           LGY+VFL+++SD LP +  GTPLIGVYF +C++L+V SL ETIFI  L+H    Q  P+P
Sbjct: 267 LGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQ-QPVP 325

Query: 360 RWLHSLLLHCNSPGRCC--------PTAPQKENK-----GPGLTPTHLPG----VKEPEV 402
            WL  L+L   +   C         P A  +  K       G   +H+ G     K P  
Sbjct: 326 AWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD 385

Query: 403 SAGQMPGPAEAELT--GGSEWTRAQREHEAQKQHSVEL---WLQFSHAMDAMLFRLYLLF 457
                P P EA L   G  +   + R+   ++    E+   WL+    +D +LF +YLL 
Sbjct: 386 RCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 445

Query: 458 MASSIITVICLWN 470
           + +  IT++ LW+
Sbjct: 446 VLAYSITLVMLWS 458


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  277 bits (709), Expect = 1e-74
 Identities = 169/465 (36%), Positives = 254/465 (54%), Gaps = 65/465 (13%)

Query: 66  RKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGI 125
           RK  RPV +   PT V+I   + AIL+V+E+  +L++++W    W + F+ WNPE+ + I
Sbjct: 52  RKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNI 111

Query: 126 TKMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185
           TK+S+   ++W+PDI I E +DV K+P     Y+ ++G ++  KP++V + C+LDI+ FP
Sbjct: 112 TKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFP 171

Query: 186 FDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITD---ASRNILQTHGEWELLGLSKATAKL 242
           FD QNC+LTF+S+L+T+     D+   +W + +   + R++    GEWELLG+     + 
Sbjct: 172 FDVQNCSLTFTSWLHTIQ----DINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREF 227

Query: 243 S-RGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLL 301
           S    N Y ++ FYV IRRRP  YV++LL+PS FL+ +D + FYLP  SG RV FKITLL
Sbjct: 228 SMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLL 287

Query: 302 LGYNVFLLMMSDLLPTS--GTPLI--------------------------------GVYF 327
           LGY+VFL+++SD LP +  GTPLI                                GVYF
Sbjct: 288 LGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYF 347

Query: 328 ALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCC--------PTA 379
            +C++L+V SL ETIFI  L+H    Q  P+P WL  L+L   +   C         P A
Sbjct: 348 VVCMALLVISLAETIFIVRLVHKQDLQ-QPVPAWLRHLVLERIAWLLCLREQSTSQRPPA 406

Query: 380 PQKENK-----GPGLTPTHLPG----VKEPEVSAGQMPGPAEAELT--GGSEWTRAQREH 428
             +  K       G   +H+ G     K P       P P EA L   G  +   + R+ 
Sbjct: 407 TSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQF 466

Query: 429 EAQKQHSVEL---WLQFSHAMDAMLFRLYLLFMASSIITVICLWN 470
             ++    E+   WL+    +D +LF +YLL + +  IT++ LW+
Sbjct: 467 LEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWS 511


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  210 bits (534), Expect = 3e-54
 Identities = 134/405 (33%), Positives = 208/405 (51%), Gaps = 16/405 (3%)

Query: 67  KPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGIT 126
           K  RPV N +  T V +   + AILDV+ +  +L + +W + VW++ F+SWN    + I 
Sbjct: 45  KEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIR 104

Query: 127 KMSMAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPF 186
           ++S+    +W PDI I E +D+++ P     YV++ G I   KP++V S C+L+ + FPF
Sbjct: 105 EISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPF 164

Query: 187 DQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGG 246
           D QNC+LTF S L+TV+ + L   +   +I    +  L    EWELL +S   + L    
Sbjct: 165 DVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFL-NDSEWELLSVSSTYSILQSSA 223

Query: 247 NLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNV 306
             + QI F V +RR P +YV++LL+PS FL+ +D  SFYLP     R+ FK ++L+GY V
Sbjct: 224 GGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTV 283

Query: 307 FLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHS 364
           F + MS+ +P S   TPLIG +F +C++ +V SL ++I +   LH         P     
Sbjct: 284 FRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQP----F 339

Query: 365 LLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRA 424
           L L     G      P+ E +      T      E     G +     ++L   S + + 
Sbjct: 340 LCLR----GDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLK-EVWSQLQSISNYLQT 394

Query: 425 QREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLW 469
           Q + + Q+      WL      D +LF+ YL  +    IT+  LW
Sbjct: 395 QDQTDQQEAE----WLVLLSRFDRLLFQSYLFMLGIYTITLCSLW 435


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  169 bits (427), Expect = 7e-42
 Identities = 87/302 (28%), Positives = 161/302 (53%), Gaps = 10/302 (3%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RPV +      V +   +S I D++E+  +L+++LW+  +W + +++W+ ++ +G+  + 
Sbjct: 47  RPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIR 106

Query: 130 MAAKNLWLPDIFIIELMDVDKT-PKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188
           + +  +W PDI +    D + + P      +  +G I +  P    S C +D+ YFPFD 
Sbjct: 107 IPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDN 166

Query: 189 QNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRG--G 246
           Q C LTF S+ Y  + + +    +  +++D   ++     EWE+ G+      +S G   
Sbjct: 167 QQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDV-----EWEVHGMPAVKNVISYGCCS 221

Query: 247 NLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNV 306
             Y  + F + ++RR S Y++NLL+P   +  +  LSFYLP  SG +V   +T+LL   V
Sbjct: 222 EPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTV 281

Query: 307 FLLMMSDLLPTS-GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSL 365
           F LM+++++P S   PLIG Y+   ++L+  S   TI + + +H    +  P+P W   +
Sbjct: 282 FQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMN-IHFCGAEARPVPHWARVV 340

Query: 366 LL 367
           +L
Sbjct: 341 IL 342


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  168 bits (425), Expect = 1e-41
 Identities = 115/412 (27%), Positives = 190/412 (46%), Gaps = 24/412 (5%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RPV +      V +   +S I+D++E+  +L+ +LW+   W + ++ W+P    G+  + 
Sbjct: 46  RPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIR 105

Query: 130 MAAKNLWLPDIFIIELMDVDKTPKGLTAYV-SNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188
           + +  +W PDI +    D        T  V  ++G +R+  P    S C +D+  FPFD 
Sbjct: 106 IPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDA 165

Query: 189 QNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRG--G 246
           Q+C LTF S+ +    + +        + D   N+     EW +LG+      L+ G   
Sbjct: 166 QHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENV-----EWRVLGMPARRRVLTYGCCS 220

Query: 247 NLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNV 306
             Y  + F + +RRR + YV NLL+P   +  +  L+F+LP  SG +V   +T+LL   V
Sbjct: 221 EPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTV 280

Query: 307 FLLMMSDLL-PTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSL 365
           F L++++ + P    PLIG Y+   ++++  S   TI I + LH       P+P W  +L
Sbjct: 281 FQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMN-LHYCGPSVRPVPAWARAL 339

Query: 366 LLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPA---------EAELT 416
           LL   + G C     + E  G    P   P  + PE  AG   GP          EA L 
Sbjct: 340 LLGHLARGLC--VRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLH 397

Query: 417 GGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICL 468
             +      R H A  Q   E W + +  MD   F L + F  + +++++ L
Sbjct: 398 HVATIANTFRSHRA-AQRCHEDWKRLARVMDR--FFLAIFFSMALVMSLLVL 446


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  162 bits (410), Expect = 6e-40
 Identities = 94/306 (30%), Positives = 161/306 (52%), Gaps = 17/306 (5%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RPV N+S P  V+   A++ + +V+E   ++ + LWL  +W++  + W+P E +GI  + 
Sbjct: 50  RPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLR 109

Query: 130 MAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188
           + A  +W PDI +      D   +G T A +   G I +  P    S C +DI +FPFD 
Sbjct: 110 VPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDH 169

Query: 189 QNCTLTFSSFLY---TVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLS--KATAKLS 243
           QNC+L F S+ Y    +D +++  + ++        N    + EWE++  S  K   K +
Sbjct: 170 QNCSLKFGSWTYDKAEIDLLIIGSKVDM--------NDFWENSEWEIIDASGYKHDIKYN 221

Query: 244 RGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLG 303
               +Y  I +   IRR P  Y INL++P  F+  +  L FYLP   G +V   I++LL 
Sbjct: 222 CCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLS 281

Query: 304 YNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRW 361
             VFLL++++ +P++    PL+G Y    +  +  S++ T+F+ + +H  T     +PRW
Sbjct: 282 LTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLN-IHYRTPTTHTMPRW 340

Query: 362 LHSLLL 367
           + ++ L
Sbjct: 341 VKTVFL 346


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  162 bits (409), Expect = 8e-40
 Identities = 111/408 (27%), Positives = 201/408 (49%), Gaps = 20/408 (4%)

Query: 66  RKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGI 125
           +K  RPV + +   +V     +S ++DV+E+  L+++ +WL+  W +  + WNP++  GI
Sbjct: 41  QKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGI 100

Query: 126 TKMSMAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPMKVDSICNLDIFYF 184
             + + +++LWLPDI + E  D       +T   V + G + +  P    S C +D+ +F
Sbjct: 101 HSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFF 160

Query: 185 PFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSR 244
           PFD+QNC++ F S+ Y  D  ++D+   +    +  R     +GEWE+L           
Sbjct: 161 PFDRQNCSMKFGSWTY--DGTMVDL---ILINENVDRKDFFDNGEWEILNAKGMKGNRRD 215

Query: 245 GGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGY 304
           G   Y  I +   +RR P  Y + L++P   L  +  L FYLP   G ++    ++L+  
Sbjct: 216 GVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSL 275

Query: 305 NVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWL 362
            VFLL++ +++P+S    PLIG Y    +  +  S++ T+F+ ++ H +++   P+  W+
Sbjct: 276 TVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWV 335

Query: 363 HSLLLHCNSPGRCCP-------TAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAEL 415
             L L    P   C        ++P+KE   P +    L   K+ ++S G+    A  E 
Sbjct: 336 KRLFLQ-KLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEK 394

Query: 416 TGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYL-LFMASSI 462
              S   R    H  +K+H +   +Q    +  +L R++L LF+  S+
Sbjct: 395 AADS--IRYISRH-VKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSV 439


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  161 bits (407), Expect = 1e-39
 Identities = 92/321 (28%), Positives = 173/321 (53%), Gaps = 15/321 (4%)

Query: 55  ADPTALNSVFN--RKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDN 112
           A+   L  +F+   K  RPV NIS    V    +++ ++DV+E+  ++++ +W++  W +
Sbjct: 36  AEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHD 95

Query: 113 PFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPM 171
             + W+P + E +T + + ++ +W PDI +    D D     LT A++ ++GR+++  P 
Sbjct: 96  YKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPA 155

Query: 172 KVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSM-LLDMEKEVWEITDASRNILQTHGEW 230
              S C++D+ +FPFDQQNCT+ F S+ Y    + L++M   V ++           GEW
Sbjct: 156 IYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLD------FWESGEW 209

Query: 231 ELLGL--SKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPV 288
            ++    +  T K      +Y  I +   IRR P  Y INL++P   +  +  L FYLP 
Sbjct: 210 VIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPS 269

Query: 289 KSGNRVPFKITLLLGYNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITH 346
           + G ++   I++LL   VFLL++++++P++    PLIG Y    +  +  S++ T+F+ +
Sbjct: 270 ECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN 329

Query: 347 LLHVATTQPPPLPRWLHSLLL 367
            +H  + +   +P W+  + L
Sbjct: 330 -VHHRSPRTHTMPTWVRRVFL 349


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  159 bits (401), Expect = 7e-39
 Identities = 95/313 (30%), Positives = 159/313 (50%), Gaps = 29/313 (9%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RPV N+S P  ++   +MS ++ V+E   ++ + LWL+ +W++  + WNP +  G   M 
Sbjct: 51  RPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMR 110

Query: 130 MAAKNLWLPDIFI----IELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185
           + A+ +W PDI +    +    VD   K L  Y    G + +  P    S C +D+ YFP
Sbjct: 111 VPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYT---GEVTWIPPAIFKSSCKIDVTYFP 167

Query: 186 FDQQNCTLTFSSFLY---TVDSMLLDME---KEVWEITDASRNILQTHGEWELLGLS--K 237
           FD QNCT+ F S+ Y    +D +L+      K+ WE            GEW ++     K
Sbjct: 168 FDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWE-----------SGEWAIIKAPGYK 216

Query: 238 ATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFK 297
              K +    +Y  I + + IRR P  Y INL++P   +  +  L FYLP   G +V   
Sbjct: 217 HDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLC 276

Query: 298 ITLLLGYNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQP 355
           I++LL   VFLL++++ +P++    PLIG Y    +  +  S++ T+F+ + +H  T   
Sbjct: 277 ISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN-VHYRTPTT 335

Query: 356 PPLPRWLHSLLLH 368
             +P W+ ++ L+
Sbjct: 336 HTMPSWVKTVFLN 348


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  158 bits (400), Expect = 9e-39
 Identities = 84/305 (27%), Positives = 161/305 (52%), Gaps = 11/305 (3%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RPV N S    V    +++ ++DV+E+  ++++ +WL+  W +  + WNP +   IT + 
Sbjct: 75  RPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLR 134

Query: 130 MAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188
           + ++ +W+PDI +    D +     +T A++ + G + +  P    S C++D+ +FPFDQ
Sbjct: 135 VPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQ 194

Query: 189 QNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKA--TAKLSRGG 246
           QNC + F S+ Y    + L+  ++  ++ D   +     GEW ++  +    + K     
Sbjct: 195 QNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWES-----GEWAIVNATGTYNSKKYDCCA 249

Query: 247 NLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNV 306
            +Y  + +   IRR P  Y INL++P   +  +  L FYLP   G ++   I++LL   V
Sbjct: 250 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV 309

Query: 307 FLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHS 364
           FLL++++++P++    PLIG Y    +  +  S++ T+F+ + +H  +     +P W+  
Sbjct: 310 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPSTHTMPHWVRG 368

Query: 365 LLLHC 369
            LL C
Sbjct: 369 ALLGC 373


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  158 bits (399), Expect = 1e-38
 Identities = 92/319 (28%), Positives = 170/319 (53%), Gaps = 15/319 (4%)

Query: 52  QHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWD 111
           +H  DP+  N     K  RP TN S    V +  +++ ++ V+E+  ++++ +WL   W+
Sbjct: 34  EHLLDPSRYN-----KLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWE 88

Query: 112 NPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMD-VDKTPKGLTAYVSNEGRIRYKKP 170
           +  ++W PEE + + K+ + +K++WLPD+ +    D + +      A VS +G I +  P
Sbjct: 89  DYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPP 148

Query: 171 MKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEW 230
               S C +++ +FPFDQQNCT+ F S+ Y    + L ++ EV  + D + +     GEW
Sbjct: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPS-----GEW 203

Query: 231 ELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKS 290
           +++ L       +   + Y  I +   IRR+P  Y INL++P   + ++  L FYLP   
Sbjct: 204 DIVAL-PGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC 262

Query: 291 GNRVPFKITLLLGYNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLL 348
           G ++   I++LL   VFLL++S ++P +    PL+G Y    + L+  S++ ++ + ++ 
Sbjct: 263 GEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVH 322

Query: 349 HVATTQPPPLPRWLHSLLL 367
           H + T     P W+  + L
Sbjct: 323 HRSPTTHTMAP-WVKVVFL 340


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  150 bits (380), Expect = 2e-36
 Identities = 95/305 (31%), Positives = 157/305 (51%), Gaps = 15/305 (4%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RPV N S P  V  S ++  I+DV+E+  +L++ +WL+M W + ++ WN  E  G+  + 
Sbjct: 42  RPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVR 101

Query: 130 MAAKNLWLPDIFIIELMD--VDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFD 187
                +W PDI +    D   D T       V++ G  +Y  P    S C +D+ +FPFD
Sbjct: 102 FPDGQIWKPDILLYNSADERFDAT-FHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFD 160

Query: 188 QQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGL--SKATAKLSRG 245
            Q+C L F S+ Y   S+ L M++      D S  I   +GEW+L+G+   ++       
Sbjct: 161 VQHCKLKFGSWSYGGWSLDLQMQE-----ADISGYI--PNGEWDLVGIPGKRSERFYECC 213

Query: 246 GNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYN 305
              Y  + F V +RRR   Y +NLL+P   + A+  L F LP  SG ++   IT+LL   
Sbjct: 214 KEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLT 273

Query: 306 VFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLH 363
           VF+L++++++P  +   PLI  YFA  + ++  S++ T+ +    H        +P+W  
Sbjct: 274 VFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKWTR 332

Query: 364 SLLLH 368
            +LL+
Sbjct: 333 VILLN 337


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  148 bits (374), Expect = 9e-36
 Identities = 94/378 (24%), Positives = 183/378 (48%), Gaps = 35/378 (9%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RP   +    +V++   ++ ++ +NE+   +S+ ++L++ W +  +SW+P E +GI  + 
Sbjct: 43  RPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLR 102

Query: 130 MAAKNLWLPDIFIIELMDVD-KTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188
           + A+++WLPD+ ++   D +      ++  VS++G +R++ P    S C++ + YFPFD 
Sbjct: 103 ITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDW 162

Query: 189 QNCTLTFSSFLYTVDSMLLDM----EKEVWEITDASRNILQTHGEWELLGLSKATAKLS- 243
           QNCT+ FSS+ Y    + L      + +  +           +G+WE++       +   
Sbjct: 163 QNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPG 222

Query: 244 --RGGN--LYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKIT 299
             RGG      +++FY+ IRR+P  Y++N++ P   +  +    FYLP  +G ++   I 
Sbjct: 223 DPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIF 282

Query: 300 LLLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPP 357
            LL   VFLL+++D +P +    P+I  Y    + L+  S++ ++ + + LH  +     
Sbjct: 283 ALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLN-LHHRSPHTHQ 341

Query: 358 LPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTG 417
           +P W+  + +H                      P +L  +K P+     MP P     + 
Sbjct: 342 MPLWVRQIFIH--------------------KLPLYL-RLKRPKPERDLMPEPPHCS-SP 379

Query: 418 GSEWTRAQREHEAQKQHS 435
           GS W R   E+  +K  S
Sbjct: 380 GSGWGRGTDEYFIRKPPS 397


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  147 bits (372), Expect = 2e-35
 Identities = 89/312 (28%), Positives = 154/312 (49%), Gaps = 10/312 (3%)

Query: 60  LNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNP 119
           LN        RP T+ S    + +  +++ ++ VNE+  ++++ +WL+  W +  ++WN 
Sbjct: 35  LNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNS 94

Query: 120 EECEGITKMSMAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPMKVDSICN 178
              EG+  + + AK +WLPDI +    D        T   V + G + +  P    S C 
Sbjct: 95  SRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVLWLPPAIYKSACK 154

Query: 179 LDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKA 238
           +++ YFPFDQQNCTL F S+ Y  D   +DM   V     AS +     GEW+++ L   
Sbjct: 155 IEVKYFPFDQQNCTLKFRSWTY--DHTEIDM---VLMTPTASMDDFTPSGEWDIVAL-PG 208

Query: 239 TAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKI 298
              ++     Y  + +   I+R+P  Y INL++P      +  L FYLP   G ++   I
Sbjct: 209 RRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDCGEKMTLCI 268

Query: 299 TLLLGYNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPP 356
           ++LL    FLL++S ++P +    PLIG Y    + L+  S++ ++ + ++ H + +   
Sbjct: 269 SVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHT 328

Query: 357 PLPRWLHSLLLH 368
             P W+    LH
Sbjct: 329 MAP-WVKRCFLH 339


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  146 bits (368), Expect = 5e-35
 Identities = 77/301 (25%), Positives = 153/301 (50%), Gaps = 7/301 (2%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RPV +++   ++    A+S ++DV+E+  L+++ +WL+  W +  + WNP++  GI  + 
Sbjct: 63  RPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIR 122

Query: 130 MAAKNLWLPDIFIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQ 189
           + + ++W PDI + +  D           +   G + +  P    S C +D+ +FPFD Q
Sbjct: 123 VPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQ 182

Query: 190 NCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLY 249
           NC++ F S+ Y  D   +D+   + E  D  +     +GEWE++  + +    +     Y
Sbjct: 183 NCSMKFGSWTY--DGSQVDI---ILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWY 237

Query: 250 DQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLL 309
             + +   I+R P  Y + L++P   L  +  L FYLP   G ++    ++L+   VFLL
Sbjct: 238 PYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLL 297

Query: 310 MMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLL 367
           ++ +++P+S    PLIG Y    +  +  S++ T+F  ++ H +++    +   +  + L
Sbjct: 298 VIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFL 357

Query: 368 H 368
           H
Sbjct: 358 H 358


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  132 bits (331), Expect = 9e-31
 Identities = 92/337 (27%), Positives = 153/337 (45%), Gaps = 19/337 (5%)

Query: 67  KPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGIT 126
           K  RPV +      V ++  +S ++ + E    L++ +W+E  W +  + WN EE   I+
Sbjct: 40  KELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNIS 99

Query: 127 KMSMAAKNLWLPDIFIIELMDVD-KTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185
            + +    +WLP+I +    D   +        V + G + +  P    S C + + YFP
Sbjct: 100 VLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFP 159

Query: 186 FDQQNCTLTFSSFLYTVDSMLLDMEKEV---------WEITDASRNILQTHGEWELL--- 233
           FD QNC+L FSS  YT   + L ++++          W I D        +GEWE++   
Sbjct: 160 FDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG--FTENGEWEIVHRP 217

Query: 234 GLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNR 293
                  +          I FY+ IRR+P  Y+IN+LVP   +  +  L FYLP  SG +
Sbjct: 218 ARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEK 277

Query: 294 VPFKITLLLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVA 351
               I++LL  +VFLL++S  LP +    PLIG +    + L+   ++  + + + +H  
Sbjct: 278 TSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLN-IHFR 336

Query: 352 TTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPG 388
           T     L   +  L L    P     + P ++   PG
Sbjct: 337 TPSTHVLSEGVKKLFLE-TLPELLHMSRPAEDGPSPG 372


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  130 bits (326), Expect = 3e-30
 Identities = 92/416 (22%), Positives = 187/416 (44%), Gaps = 48/416 (11%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RPV +     +V +   +  +++V+E   ++++ + L+  W +  + WNP++  G+ K+ 
Sbjct: 40  RPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIH 99

Query: 130 MAAKNLWLPDIFIIELMDVD----KTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185
           + ++ +W PD+ +    D D    K  K L  Y    G I +  P    S C + + +FP
Sbjct: 100 IPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYT---GHITWTPPAIFKSYCEIIVTHFP 156

Query: 186 FDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEW---ELLGLSKATAKL 242
           FD+QNC++   ++ Y    + ++ E +  +++    N +++ GEW   E  G   +    
Sbjct: 157 FDEQNCSMKLGTWTYDGSVVAINPESDQPDLS----NFMES-GEWVIKESRGWKHSVTYS 211

Query: 243 SRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLL 302
                 Y  I ++  ++R P  +++N+++P      +  L FYLP  SG ++   I++LL
Sbjct: 212 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLL 271

Query: 303 GYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPR 360
              VFLL++ +L+P  +S  PLIG Y    +  ++ S++ T+ + +  H  +     +P 
Sbjct: 272 SLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVIN-THHRSPSTHVMPN 330

Query: 361 WLHSLLLHC--NSPGRCCPTAPQKENK------------------GPGLTPTHLPGVKEP 400
           W+  + +    N         P +E +                  GP     H P +K P
Sbjct: 331 WVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHP 390

Query: 401 EVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLL 456
           EV +             G ++     + + +  ++   W   +  MD +L  +++L
Sbjct: 391 EVKSA----------IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 436


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  124 bits (312), Expect = 1e-28
 Identities = 83/301 (27%), Positives = 148/301 (49%), Gaps = 23/301 (7%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RP    S    V++   ++ ++ +NE+   L++ +W+EM W +  + W+P + EG+  + 
Sbjct: 42  RPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLR 101

Query: 130 MAAKNLWLPDIFIIELMD-VDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188
           + +  +W PDI +   +D V +        VS +G I +  P    S C++ + YFPFD 
Sbjct: 102 VPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDW 161

Query: 189 QNCTLTFSSFLYTVDSMLLDMEKE-----VWEITDASRNILQTHGEWEL------LGLSK 237
           QNC+L F S  Y+ + + L + +E      W   D        +GEW +      + L  
Sbjct: 162 QNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDP--EAFTENGEWAIQHRPAKMLLDP 219

Query: 238 ATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKS-GNRVPF 296
           A      G   + ++VFY+ I+R+P  YVIN++ P   + ++  L  +LP K+ G +   
Sbjct: 220 AAPAQEAG---HQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTV 276

Query: 297 KITLLLGYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQ 354
            I +LL   VFL +++  +P  +   PLI  Y      L+V ++L  +    +L+V+   
Sbjct: 277 AINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTF---LLVVTILIVVNAVVVLNVSLRS 333

Query: 355 P 355
           P
Sbjct: 334 P 334


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  119 bits (298), Expect = 6e-27
 Identities = 85/376 (22%), Positives = 166/376 (44%), Gaps = 48/376 (12%)

Query: 110 WDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDVD----KTPKGLTAYVSNEGRI 165
           W +  + WNP++  G+ K+ + ++ +W PD+ +    D D    K  K L  Y    G I
Sbjct: 105 WVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYT---GHI 161

Query: 166 RYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQ 225
            +  P    S C + + +FPFD+QNC++   ++ Y    + ++ E +  +++    N ++
Sbjct: 162 TWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLS----NFME 217

Query: 226 THGEW---ELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDAL 282
           + GEW   E  G   +          Y  I ++  ++R P  +++N+++P      +  L
Sbjct: 218 S-GEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGL 276

Query: 283 SFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLE 340
            FYLP  SG ++   I++LL   VFLL++ +L+P  +S  PLIG Y    +  ++ S++ 
Sbjct: 277 VFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIII 336

Query: 341 TIFITHLLHVATTQPPPLPRWLHSLLLHC--NSPGRCCPTAPQKENK------------- 385
           T+ + +  H  +     +P W+  + +    N         P +E +             
Sbjct: 337 TVIVIN-THHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISD 395

Query: 386 -----GPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWL 440
                GP     H P +K PEV +             G ++     + + +  ++   W 
Sbjct: 396 ISGKPGPPPMGFHSPLIKHPEVKSA----------IEGIKYIAETMKSDQESNNAAAEWK 445

Query: 441 QFSHAMDAMLFRLYLL 456
             +  MD +L  +++L
Sbjct: 446 YVAMVMDHILLGVFML 461


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  110 bits (274), Expect = 4e-24
 Identities = 69/308 (22%), Positives = 146/308 (47%), Gaps = 11/308 (3%)

Query: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129
           RPV        +++   ++ ++ +NE+   L++ +W+ + W +  ++++ ++  GI  + 
Sbjct: 40  RPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLR 99

Query: 130 MAAKNLWLPDIFIIELMDVD-KTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188
           + ++ +WLP+I +   +D            V   G + +  P    S+C +++ YFPFD 
Sbjct: 100 VPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDW 159

Query: 189 QNCTLTFSSFLYTVD----SMLLDMEKEVWEITDASRNILQTHGEWEL---LGLSKATAK 241
           QNC+L F S  Y  +    +  +D + +     D        +GEW +    G+ +    
Sbjct: 160 QNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHG 219

Query: 242 LSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKS-GNRVPFKITL 300
            +  G     +++ + IRR+P  YVIN++VP   +  +  L+++LP ++ G +    I +
Sbjct: 220 GATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINV 279

Query: 301 LLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPL 358
           LL   VFL +++  +P +    PL+G +    + +    ++  + + ++     T     
Sbjct: 280 LLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMS 339

Query: 359 PRWLHSLL 366
           PR  H LL
Sbjct: 340 PRLRHVLL 347


>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
          Length = 412

 Score =  105 bits (262), Expect = 9e-23
 Identities = 100/390 (25%), Positives = 176/390 (45%), Gaps = 56/390 (14%)

Query: 26  ALLHLTHSMSTTGRGVTFT-INCSGF-GQHGADPTALNSVFNRKPFRPV---TNISVPTQ 80
           +LLHLT      G  +T   ++  GF G     P+  N   ++K    +    N S P  
Sbjct: 6   SLLHLTF----LGFSITLLLVHGQGFQGTAAIWPSLFNVNLSKKVQESIQIPNNGSAPLL 61

Query: 81  VNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDI 140
           V++   +S + +V+   + +SS L L + W +  ++WN         +++  ++LW P +
Sbjct: 62  VDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTS-AHPRHAITLPWESLWTPRL 120

Query: 141 FIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLY 200
            I+E + VD   +   A V  +G ++    +  ++ CN ++ +FP D  NC+L+F    Y
Sbjct: 121 TILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSF----Y 176

Query: 201 TVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIV--FYVAI 258
            + +  +++E +   + +    I+    E+ +  L               Q+V  F V +
Sbjct: 177 ALSNTAMELEFQAHVVNE----IVSVKREYVVYDLKTQVPP--------QQLVPCFQVTL 224

Query: 259 RRRPSLY--VINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLP 316
           R + +    +I LLVP+  L+  D     LP+++  R+ +K+TLLL Y V    +   LP
Sbjct: 225 RLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALP 284

Query: 317 TSGT--PLIGVYFALCLSLMVGSLLETIFITHLLH----VATTQPPPLPRWLHSLLLHCN 370
           +S +  PL+  YF + L L+  S +ET+ +  LL      A + P P PR          
Sbjct: 285 SSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPR---------- 334

Query: 371 SPGRCCPTAPQKENKGPGLTPTHLP--GVK 398
                     Q+E+  PG  P   P  GVK
Sbjct: 335 --------GEQREHGNPGPHPAEEPSRGVK 356


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  104 bits (260), Expect = 2e-22
 Identities = 67/214 (31%), Positives = 112/214 (52%), Gaps = 12/214 (5%)

Query: 159 VSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITD 218
           V++ G  +Y  P    S C +D+ +FPFD Q+C L F S+ Y   S+ L M++      D
Sbjct: 42  VNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQE-----AD 96

Query: 219 ASRNILQTHGEWELLGL--SKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFL 276
            S  I   +GEW+L+G+   ++          Y  + F V +RRR   Y +NLL+P   +
Sbjct: 97  ISGYI--PNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 154

Query: 277 VAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLM 334
            A+  L F LP  SG ++   IT+LL   VF+L++++++P  +   PLI  YFA  + ++
Sbjct: 155 SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 214

Query: 335 VGSLLETIFITHLLHVATTQPPPLPRWLHSLLLH 368
             S++ T+ +    H        +P+W   +LL+
Sbjct: 215 GLSVVVTVIVLQ-YHHHDPDGGKMPKWTRVILLN 247


>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
           [Homo sapiens]
          Length = 632

 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 71/314 (22%), Positives = 133/314 (42%), Gaps = 18/314 (5%)

Query: 46  NCSGFGQHGADPTALNSVFNRKPFRPVTNIS-VPTQVNISFAMSAILDVNEQLHLLSSFL 104
           NC            L+ V +R   R   N    P  V IS  +++I  ++E     +  +
Sbjct: 49  NCKNCANEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITM 108

Query: 105 WLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMDV---DKTPKGLTAYVSN 161
           +    W +  +++  E    +T      + LW+PD + +   D    D T +     +  
Sbjct: 109 FFHQTWKDSRLAYY-ETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHP 167

Query: 162 EGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASR 221
           +G +RY   +   + C+LD+  FP D+Q C L   S+ YTV+ ++L      W+  D   
Sbjct: 168 DGTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIIL-----FWD--DNGN 220

Query: 222 NILQTH----GEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLV 277
            I  T      ++  LG +  + ++      Y +++    ++R  + Y++ +  P+    
Sbjct: 221 AIHMTEELHIPQFTFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTT 280

Query: 278 AIDALSFYLPV-KSGNRVPFKITLLLGYNVFLLMMSDLLPT-SGTPLIGVYFALCLSLMV 335
               +SF++    S  RV   +T +L        + D LP  S    I +Y  +CL  + 
Sbjct: 281 ITSWISFWMNYDSSAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVF 340

Query: 336 GSLLETIFITHLLH 349
            SLLE ++I +L +
Sbjct: 341 LSLLEYVYINYLFY 354


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score = 76.3 bits (186), Expect = 6e-14
 Identities = 44/146 (30%), Positives = 78/146 (53%), Gaps = 5/146 (3%)

Query: 227 HGEWELLGL--SKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSF 284
           +GEW+L+G+   ++          Y  + F V +RRR   Y +NLL+P   + A+  L F
Sbjct: 12  NGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVF 71

Query: 285 YLPVKSGNRVPFKITLLLGYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLETI 342
            LP  SG ++   IT+LL   VF+L++++++P  +   PLI  YFA  + ++  S++ T+
Sbjct: 72  LLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTV 131

Query: 343 FITHLLHVATTQPPPLPRWLHSLLLH 368
            +    H        +P+W   +LL+
Sbjct: 132 IVLQ-YHHHDPDGGKMPKWTRVILLN 156


>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
           sapiens]
          Length = 479

 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 88/405 (21%), Positives = 165/405 (40%), Gaps = 28/405 (6%)

Query: 71  PVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSM 130
           P   + V  QV    ++ +I +V+    +    L+L   W +  +S+       +T    
Sbjct: 95  PAIPVGVDVQVE---SLDSISEVDMDFTMT---LYLRHYWKDERLSFPSTNNLSMTFDGR 148

Query: 131 AAKNLWLPDIFIIELMDV---DKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFD 187
             K +W+PD+F +        D T   +   V  +G++ Y   + V ++CN+D   FP D
Sbjct: 149 LVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLD 208

Query: 188 QQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGN 247
            Q C+L   S+ YT D ++L  +K    +    R  L      E    +K     S G  
Sbjct: 209 TQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTG-- 266

Query: 248 LYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKS-GNRVPFKITLLLGYNV 306
            Y+++     +RR    +++    P+  +V +  +SF++  ++   RVP  IT +L  + 
Sbjct: 267 WYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMST 326

Query: 307 FLLMMSDLLP-TSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSL 365
            +  ++  +P  S    + +Y  +    +  S+LE   + +L  V   +   L       
Sbjct: 327 IITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLRE----- 381

Query: 366 LLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQ 425
            L C S      TA    N   G     +  +       G+ P     +LT  SE +  Q
Sbjct: 382 KLPCTSGLPPPRTAMLDGNYSDG----EVNDLDNYMPENGEKPDRMMVQLTLASERSSPQ 437

Query: 426 REHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWN 470
           R+ +     S+ +    +HA+D       ++F A+ I+  +  W+
Sbjct: 438 RKSQRSSYVSMRI---DTHAIDKY---SRIIFPAAYILFNLIYWS 476


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,463,709
Number of Sequences: 37866
Number of extensions: 947859
Number of successful extensions: 2752
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2562
Number of HSP's gapped (non-prelim): 88
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.