BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2 [Homo sapiens] (279 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2 [... 571 e-163 gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 ... 547 e-156 gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens] 377 e-105 gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens] 301 5e-82 gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform... 117 1e-26 gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform... 117 1e-26 gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform... 116 2e-26 gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi... 67 2e-11 gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor... 63 3e-10 gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [... 61 9e-10 gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec... 57 1e-08 gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre... 57 1e-08 gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ... 55 7e-08 gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens] 54 2e-07 gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr... 54 2e-07 gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec... 52 4e-07 gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens] 52 8e-07 gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens] 51 1e-06 gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens] 51 1e-06 gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H... 51 1e-06 gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [... 50 2e-06 gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec... 48 1e-05 gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec... 47 2e-05 gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens] 46 4e-05 gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens] 43 3e-04 gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ... 41 0.001 gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens] 38 0.009 gi|88702793 slit-like 2 [Homo sapiens] 35 0.073 gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p... 34 0.16 gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon p... 33 0.28 >gi|47519877 5-hydroxytryptamine receptor 3 subunit D isoform 2 [Homo sapiens] Length = 279 Score = 571 bits (1472), Expect = e-163 Identities = 279/279 (100%), Positives = 279/279 (100%) Query: 1 MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVAIRRRCRPSPYV 60 MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVAIRRRCRPSPYV Sbjct: 1 MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVAIRRRCRPSPYV 60 Query: 61 VNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASL 120 VNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASL Sbjct: 61 VNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASL 120 Query: 121 VRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQ 180 VRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQ Sbjct: 121 VRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQ 180 Query: 181 GRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQK 240 GRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQK Sbjct: 181 GRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQK 240 Query: 241 QHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 279 QHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT Sbjct: 241 QHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 279 >gi|223468705 5-hydroxytryptamine receptor 3 subunit D isoform 1 [Homo sapiens] Length = 404 Score = 547 bits (1410), Expect = e-156 Identities = 279/330 (84%), Positives = 279/330 (84%), Gaps = 51/330 (15%) Query: 1 MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQV------------ 48 MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQV Sbjct: 75 MASMSIVKATSNTISQCGWSASANWTPSISPSMDRGERSPSALSPTQVTRAWRRMSRSFQ 134 Query: 49 ---------------------------------------AIRRRCRPSPYVVNFLVPSGI 69 AIRRRCRPSPYVVNFLVPSGI Sbjct: 135 IHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGI 194 Query: 70 LIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQ 129 LIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQ Sbjct: 195 LIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQ 254 Query: 130 KRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQ 189 KRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQ Sbjct: 255 KRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQ 314 Query: 190 KGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQ 249 KGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQ Sbjct: 315 KGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQ 374 Query: 250 FSHAMDALLFRLYLLFMASSIITVICLWNT 279 FSHAMDALLFRLYLLFMASSIITVICLWNT Sbjct: 375 FSHAMDALLFRLYLLFMASSIITVICLWNT 404 >gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens] Length = 471 Score = 377 bits (969), Expect = e-105 Identities = 190/232 (81%), Positives = 202/232 (87%), Gaps = 16/232 (6%) Query: 48 VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMND 107 VAIRRR PS YV+N LVPSG L+AIDALSFYLP++SGN PFK+T+LLGY+VFLLMM+D Sbjct: 256 VAIRRR--PSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSD 313 Query: 108 LLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLP 167 LLP + T L+ GVYFALCLSLMVGSLLETIFITHLLHVATTQP PLP Sbjct: 314 LLPTSGTP----LI----------GVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLP 359 Query: 168 RWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGS 227 RWLHSLLLHC GRCCPTAPQK NKGPGLTPTHLPGVKEPEVSAGQMPGP EAELTGGS Sbjct: 360 RWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGS 419 Query: 228 EWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 279 EWTRAQREHEAQKQHSVELW+QFSHAMDA+LFRLYLLFMASSIITVICLWNT Sbjct: 420 EWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT 471 >gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens] Length = 447 Score = 301 bits (770), Expect = 5e-82 Identities = 160/232 (68%), Positives = 175/232 (75%), Gaps = 25/232 (10%) Query: 48 VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMND 107 VAIRRR PS Y++N LVPS L+AIDALSFYLP ES N APFK+T+LLGY+VFLLMMND Sbjct: 241 VAIRRR--PSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMND 298 Query: 108 LLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLP 167 LLPA+ T + VYFALCLSLMV SLLET+FIT+LLHVATTQP P+P Sbjct: 299 LLPASGTPLIS--------------VYFALCLSLMVVSLLETVFITYLLHVATTQPPPMP 344 Query: 168 RWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGS 227 RWLHSLLLHCT GRCCPTAPQKGNKG GLT THLPG KEP AG+ GP E E GGS Sbjct: 345 RWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGS 404 Query: 228 EWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT 279 WT+ Q +ELWVQFSHAMD LLFRLYLLFMASSI+TVI LWNT Sbjct: 405 GWTKTQ---------LMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT 447 >gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b precursor [Homo sapiens] Length = 484 Score = 117 bits (292), Expect = 1e-26 Identities = 88/253 (34%), Positives = 126/253 (49%), Gaps = 37/253 (14%) Query: 48 VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMND 107 V IRRR P YVV+ L+PS L+ +D + FYLP SG FK+T+LLGYSVFL++++D Sbjct: 242 VVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSD 299 Query: 108 LLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLP 167 LPAT+ + GVYF +C++L+V SL ETIFI L+H Q P+P Sbjct: 300 TLPATAIGTPLI------------GVYFVVCMALLVISLAETIFIVRLVHKQDLQQ-PVP 346 Query: 168 RWLHSLLLHCTGQGRCC--------PTAPQKGNK-----GPGLTPTHLPG----VKEPEV 210 WL L+L C P A + K G +H+ G K P Sbjct: 347 AWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD 406 Query: 211 SAGQMPGPGEAELT--GGSEWTRAQREHEAQKQHSVEL---WVQFSHAMDALLFRLYLLF 265 P P EA L G + + R+ ++ E+ W++ +D LLF +YLL Sbjct: 407 RCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 466 Query: 266 MASSIITVICLWN 278 + + IT++ LW+ Sbjct: 467 VLAYSITLVMLWS 479 >gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c [Homo sapiens] Length = 463 Score = 117 bits (292), Expect = 1e-26 Identities = 88/253 (34%), Positives = 126/253 (49%), Gaps = 37/253 (14%) Query: 48 VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMND 107 V IRRR P YVV+ L+PS L+ +D + FYLP SG FK+T+LLGYSVFL++++D Sbjct: 221 VVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSD 278 Query: 108 LLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLP 167 LPAT+ + GVYF +C++L+V SL ETIFI L+H Q P+P Sbjct: 279 TLPATAIGTPLI------------GVYFVVCMALLVISLAETIFIVRLVHKQDLQQ-PVP 325 Query: 168 RWLHSLLLHCTGQGRCC--------PTAPQKGNK-----GPGLTPTHLPG----VKEPEV 210 WL L+L C P A + K G +H+ G K P Sbjct: 326 AWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRD 385 Query: 211 SAGQMPGPGEAELT--GGSEWTRAQREHEAQKQHSVEL---WVQFSHAMDALLFRLYLLF 265 P P EA L G + + R+ ++ E+ W++ +D LLF +YLL Sbjct: 386 RCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 445 Query: 266 MASSIITVICLWN 278 + + IT++ LW+ Sbjct: 446 VLAYSITLVMLWS 458 >gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a precursor [Homo sapiens] Length = 516 Score = 116 bits (291), Expect = 2e-26 Identities = 92/273 (33%), Positives = 130/273 (47%), Gaps = 45/273 (16%) Query: 48 VAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMND 107 V IRRR P YVV+ L+PS L+ +D + FYLP SG FK+T+LLGYSVFL++++D Sbjct: 242 VVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSD 299 Query: 108 LLPATSTSSHASLVRPHPSRDQK--------------------RGVYFALCLSLMVGSLL 147 LPAT+ + P SR Q GVYF +C++L+V SL Sbjct: 300 TLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLA 359 Query: 148 ETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCC--------PTAPQKGNK-----G 194 ETIFI L+H Q P+P WL L+L C P A + K Sbjct: 360 ETIFIVRLVHKQDLQQ-PVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSA 418 Query: 195 PGLTPTHLPG----VKEPEVSAGQMPGPGEAELT--GGSEWTRAQREHEAQKQHSVEL-- 246 G +H+ G K P P P EA L G + + R+ ++ E+ Sbjct: 419 MGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVAR 478 Query: 247 -WVQFSHAMDALLFRLYLLFMASSIITVICLWN 278 W++ +D LLF +YLL + + IT++ LW+ Sbjct: 479 DWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWS 511 >gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapiens] Length = 450 Score = 67.0 bits (162), Expect = 2e-11 Identities = 63/234 (26%), Positives = 101/234 (43%), Gaps = 30/234 (12%) Query: 53 RCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPAT 112 R R + YV N L+P ++ + L+F+LP +SG +TVLL +VF L++ + +P Sbjct: 233 RRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPA 292 Query: 113 STSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHS 172 + L+ G Y+ ++++ S TI I + LH P+P W + Sbjct: 293 ES---VPLI----------GKYYMATMTMVTFSTALTILIMN-LHYCGPSVRPVPAWARA 338 Query: 173 LLLHCTGQGRCCPTAPQKGNK-GPGLTPTHLPGVKEPEVSAGQMPGP---------GEAE 222 LLL +G C ++G G P P + PE AG GP EA Sbjct: 339 LLLGHLARGLC---VRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEAL 395 Query: 223 LTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICL 276 L + R H A Q E W + + MD F L + F + +++++ L Sbjct: 396 LHHVATIANTFRSHRA-AQRCHEDWKRLARVMDR--FFLAIFFSMALVMSLLVL 446 >gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor [Homo sapiens] Length = 441 Score = 62.8 bits (151), Expect = 3e-10 Identities = 63/255 (24%), Positives = 104/255 (40%), Gaps = 35/255 (13%) Query: 28 SISPSMDRGERSPSALSPTQVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNC 87 S+S + + S + Q + R P YVV+ L+PS L+ +D SFYLP Sbjct: 211 SVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRAR 270 Query: 88 APFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLL 147 FK +VL+GY+VF + M++ +P + S+ G +F +C++ +V SL Sbjct: 271 IVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLI------------GHFFTICMAFLVLSLA 318 Query: 148 ETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKE 207 ++I + LH P L T R P + + V E Sbjct: 319 KSIVLVKFLHDEQRGGQEQP---FLCLRGDTDADR--PRVEPRAQRAV---------VTE 364 Query: 208 PEVSAGQMPGPGE-----AELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLY 262 + + PG ++L S + + Q + + Q+ W+ D LLF+ Y Sbjct: 365 SSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAE----WLVLLSRFDRLLFQSY 420 Query: 263 LLFMASSIITVICLW 277 L + IT+ LW Sbjct: 421 LFMLGIYTITLCSLW 435 >gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [Homo sapiens] Length = 479 Score = 61.2 bits (147), Expect = 9e-10 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 14/121 (11%) Query: 55 RPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATST 114 R S Y+VN L+P ++ + LSFYLP SG +T+LL +VF LM+ +++PA Sbjct: 236 RSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPA--- 292 Query: 115 SSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLL 174 S + L+ G Y+ ++L+ S TI + + +H + P+P W ++ Sbjct: 293 SENVPLI----------GKYYIATMALITASTALTIMVMN-IHFCGAEARPVPHWARVVI 341 Query: 175 L 175 L Sbjct: 342 L 342 >gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b precursor [Homo sapiens] Length = 457 Score = 57.4 bits (137), Expect = 1e-08 Identities = 48/229 (20%), Positives = 93/229 (40%), Gaps = 43/229 (18%) Query: 56 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 115 P ++VN ++P + + L FYLP +SG ++VLL +VFLL++ +L+P STS Sbjct: 231 PLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIP--STS 288 Query: 116 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 175 S L+ G Y + ++ S++ T+ + + H + + + +P W+ + + Sbjct: 289 SAVPLI----------GKYMLFTMVFVIASIIITVIVINTHHRSPSTHV-MPNWVRKVFI 337 Query: 176 HCTGQGRCCPTAPQ--------------------KGNKGPGLTPTHLPGVKEPEVSAGQM 215 T + G GP H P +K PEV + Sbjct: 338 DTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA-- 395 Query: 216 PGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLL 264 G ++ + + + ++ W + MD +L +++L Sbjct: 396 --------IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 436 >gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a precursor [Homo sapiens] Length = 482 Score = 57.4 bits (137), Expect = 1e-08 Identities = 48/229 (20%), Positives = 93/229 (40%), Gaps = 43/229 (18%) Query: 56 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 115 P ++VN ++P + + L FYLP +SG ++VLL +VFLL++ +L+P STS Sbjct: 256 PLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIP--STS 313 Query: 116 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 175 S L+ G Y + ++ S++ T+ + + H + + + +P W+ + + Sbjct: 314 SAVPLI----------GKYMLFTMVFVIASIIITVIVINTHHRSPSTHV-MPNWVRKVFI 362 Query: 176 HCTGQGRCCPTAPQ--------------------KGNKGPGLTPTHLPGVKEPEVSAGQM 215 T + G GP H P +K PEV + Sbjct: 363 DTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA-- 420 Query: 216 PGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLL 264 G ++ + + + ++ W + MD +L +++L Sbjct: 421 --------IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 461 >gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) [Homo sapiens] Length = 529 Score = 55.1 bits (131), Expect = 7e-08 Identities = 34/122 (27%), Positives = 61/122 (50%), Gaps = 13/122 (10%) Query: 56 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 115 P Y +N ++P ++ + L FYLP + G ++VLL +VFLL++ +++P+T Sbjct: 265 PLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPST--- 321 Query: 116 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 175 SLV P G Y + + S++ T+F+ + +H + +P W+ LL Sbjct: 322 ---SLVIP------LIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPSTHTMPHWVRGALL 371 Query: 176 HC 177 C Sbjct: 372 GC 373 >gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens] Length = 494 Score = 53.9 bits (128), Expect = 2e-07 Identities = 34/120 (28%), Positives = 60/120 (50%), Gaps = 13/120 (10%) Query: 56 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 115 P Y +N ++P + + L FYLP + G ++VLL +VFLL++ + +P+T Sbjct: 240 PMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPST--- 296 Query: 116 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 175 SLV P G Y + + S++ T+F+ + +H T +PRW+ ++ L Sbjct: 297 ---SLVVP------LVGEYLLFTMIFVTLSIVVTVFVLN-IHYRTPTTHTMPRWVKTVFL 346 >gi|4557461 nicotinic acetylcholine receptor delta polypeptide precursor [Homo sapiens] Length = 517 Score = 53.9 bits (128), Expect = 2e-07 Identities = 33/75 (44%), Positives = 45/75 (60%), Gaps = 1/75 (1%) Query: 39 SPSALSPTQVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGY 98 SPS T I RR +P Y++N LVP ++ + L FYLP +SG ++VLL Sbjct: 230 SPSRQDITFYLIIRR-KPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQ 288 Query: 99 SVFLLMMNDLLPATS 113 SVFLL+++ LPATS Sbjct: 289 SVFLLLISKRLPATS 303 >gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit precursor [Homo sapiens] Length = 627 Score = 52.4 bits (124), Expect = 4e-07 Identities = 33/120 (27%), Positives = 61/120 (50%), Gaps = 13/120 (10%) Query: 56 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 115 P Y +N ++P ++ + L FYLP E G ++VLL +VFLL++ +++P+T Sbjct: 243 PLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPST--- 299 Query: 116 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 175 SLV P G Y + + S++ T+F+ + +H + + +P W+ + L Sbjct: 300 ---SLVIP------LIGEYLLFTMIFVTLSIVITVFVLN-VHHRSPRTHTMPTWVRRVFL 349 >gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens] Length = 505 Score = 51.6 bits (122), Expect = 8e-07 Identities = 33/121 (27%), Positives = 61/121 (50%), Gaps = 13/121 (10%) Query: 56 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 115 P Y +N ++P ++ + L FYLP + G ++VLL +VFLL++ + +P+T Sbjct: 241 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPST--- 297 Query: 116 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 175 SLV P G Y + + S++ T+F+ + +H T +P W+ ++ L Sbjct: 298 ---SLVIP------LIGEYLLFTMIFVTLSIVITVFVLN-VHYRTPTTHTMPSWVKTVFL 347 Query: 176 H 176 + Sbjct: 348 N 348 >gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens] Length = 412 Score = 50.8 bits (120), Expect = 1e-06 Identities = 45/175 (25%), Positives = 77/175 (44%), Gaps = 23/175 (13%) Query: 50 IRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLL 109 + R R Y +N L+P ++ A+ L F LP +SG +TVLL +VF+L++ +++ Sbjct: 134 VTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIM 193 Query: 110 PATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRW 169 PATS S L+ YFA + ++ S++ T+ + H +P+W Sbjct: 194 PATSDS--VPLI----------AQYFASTMIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKW 240 Query: 170 LHSLLLH-CT--------GQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQM 215 +LL+ C G+ + P K + L + V P S G + Sbjct: 241 TRVILLNWCAWFLRMKRPGEDKVRPACQHK-QRRCSLASVEMSAVAPPPASNGNL 294 >gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens] Length = 321 Score = 50.8 bits (120), Expect = 1e-06 Identities = 45/175 (25%), Positives = 77/175 (44%), Gaps = 23/175 (13%) Query: 50 IRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLL 109 + R R Y +N L+P ++ A+ L F LP +SG +TVLL +VF+L++ +++ Sbjct: 43 VTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIM 102 Query: 110 PATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRW 169 PATS S L+ YFA + ++ S++ T+ + H +P+W Sbjct: 103 PATSDS--VPLI----------AQYFASTMIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKW 149 Query: 170 LHSLLLH-CT--------GQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQM 215 +LL+ C G+ + P K + L + V P S G + Sbjct: 150 TRVILLNWCAWFLRMKRPGEDKVRPACQHK-QRRCSLASVEMSAVAPPPASNGNL 203 >gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo sapiens] Length = 502 Score = 50.8 bits (120), Expect = 1e-06 Identities = 45/175 (25%), Positives = 77/175 (44%), Gaps = 23/175 (13%) Query: 50 IRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLL 109 + R R Y +N L+P ++ A+ L F LP +SG +TVLL +VF+L++ +++ Sbjct: 224 VTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIM 283 Query: 110 PATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRW 169 PATS S L+ YFA + ++ S++ T+ + H +P+W Sbjct: 284 PATSDS--VPLI----------AQYFASTMIIVGLSVVVTVIVLQ-YHHHDPDGGKMPKW 330 Query: 170 LHSLLLH-CT--------GQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQM 215 +LL+ C G+ + P K + L + V P S G + Sbjct: 331 TRVILLNWCAWFLRMKRPGEDKVRPACQHK-QRRCSLASVEMSAVAPPPASNGNL 384 >gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [Homo sapiens] Length = 458 Score = 50.4 bits (119), Expect = 2e-06 Identities = 52/222 (23%), Positives = 100/222 (45%), Gaps = 22/222 (9%) Query: 56 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 115 P Y + ++P L + L FYLP + G +VL+ +VFLL++ +++P S+S Sbjct: 233 PLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIP--SSS 290 Query: 116 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 175 L+ G Y + + S++ T+F+ ++ H +++ P+ W+ L L Sbjct: 291 KVIPLI----------GEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFL 340 Query: 176 HCTGQGRCCP------TAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEW 229 + C ++P+K P + L K+ ++S G+ A L ++ Sbjct: 341 QKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEK--VLVAFLEKAADS 398 Query: 230 TRAQREHEAQKQHSVELWVQFSHAMDALLFRLYL-LFMASSI 270 R H +K+H + VQ + +L R++L LF+ S+ Sbjct: 399 IRYISRH-VKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSV 439 >gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 precursor [Homo sapiens] Length = 502 Score = 47.8 bits (112), Expect = 1e-05 Identities = 32/123 (26%), Positives = 61/123 (49%), Gaps = 13/123 (10%) Query: 53 RCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPAT 112 R +P Y +N ++P ++ ++ L FYLP + G ++VLL +VFLL+++ ++P T Sbjct: 231 RRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPT 290 Query: 113 STSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHS 172 S LV G Y + L+ S++ ++ + ++ H + T P W+ Sbjct: 291 SLD--VPLV----------GKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAP-WVKV 337 Query: 173 LLL 175 + L Sbjct: 338 VFL 340 >gi|41327726 nicotinic acetylcholine receptor beta 1 subunit precursor [Homo sapiens] Length = 501 Score = 47.0 bits (110), Expect = 2e-05 Identities = 50/213 (23%), Positives = 83/213 (38%), Gaps = 36/213 (16%) Query: 31 PSMDRGERSPSALSPTQVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPF 90 P RG R I RR +P Y+VN + P ++ + FYLP ++G Sbjct: 221 PGDPRGGREGQRQEVIFYLIIRR-KPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGL 279 Query: 91 KMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETI 150 + LL +VFLL++ D +P TS S + Y + L+ S++ ++ Sbjct: 280 SIFALLTLTVFLLLLADKVPETSLSVPIII------------KYLMFTMVLVTFSVILSV 327 Query: 151 FITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEV 210 + + LH + +P W+ + +H P +L +K P+ Sbjct: 328 VVLN-LHHRSPHTHQMPLWVRQIFIH--------------------KLPLYL-RLKRPKP 365 Query: 211 SAGQMPGPGEAELTGGSEWTRAQREHEAQKQHS 243 MP P + GS W R E+ +K S Sbjct: 366 ERDLMPEPPHCS-SPGSGWGRGTDEYFIRKPPS 397 >gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens] Length = 498 Score = 45.8 bits (107), Expect = 4e-05 Identities = 39/165 (23%), Positives = 72/165 (43%), Gaps = 15/165 (9%) Query: 13 TISQCGWSASANWTPSISPSMDR-GERSPSALSPTQVAIRRRCRPSPYVVNFLVPSGILI 71 T S ++ S W P + PS + T I +R +P Y +N ++P + Sbjct: 189 TASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKR-KPLFYTINLIIPCVLTT 247 Query: 72 AIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPHPSRDQKR 131 + L FYLP + G ++VLL + FLL+++ ++P TS L+ Sbjct: 248 LLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLD--VPLI---------- 295 Query: 132 GVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLH 176 G Y + L+ S++ ++ + ++ H + + P W+ LH Sbjct: 296 GKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAP-WVKRCFLH 339 >gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens] Length = 412 Score = 43.1 bits (100), Expect = 3e-04 Identities = 40/137 (29%), Positives = 59/137 (43%), Gaps = 23/137 (16%) Query: 40 PSALSPT-QVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGY 98 P L P QV +R + ++ LVP+ L+ D LPL + +K+T+LL Y Sbjct: 213 PQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSY 272 Query: 99 SVFLLMMNDLLPATSTSSHASLVRPHPSRDQKRGV---YFALCLSLMVGSLLETIFITHL 155 V H+SLV+ PS + YF + L L+ S +ET+ + L Sbjct: 273 LVL---------------HSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGL 317 Query: 156 LH----VATTQPLPLPR 168 L A + P P PR Sbjct: 318 LARGNLGAKSGPSPAPR 334 >gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide precursor [Homo sapiens] Length = 493 Score = 41.2 bits (95), Expect = 0.001 Identities = 25/102 (24%), Positives = 49/102 (48%), Gaps = 5/102 (4%) Query: 19 WSASANWTPSISPSMDRGERSPSALSPTQV----AIRRRCRPSPYVVNFLVPSGILIAID 74 ++ + W P + R + P + ++ R +P YV+N +VP ++ + Sbjct: 199 YTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLV 258 Query: 75 ALSFYLPLES-GNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 115 L+++LP ++ G + VLL +VFL ++ +P TS S Sbjct: 259 LLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLS 300 >gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens] Length = 468 Score = 38.1 bits (87), Expect = 0.009 Identities = 28/121 (23%), Positives = 55/121 (45%), Gaps = 12/121 (9%) Query: 56 PSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTS 115 P Y + ++P L + L FYLP G +VL+ +VFLL++ +++P S+S Sbjct: 250 PLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIP--SSS 307 Query: 116 SHASLVRPHPSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLL 175 L+ G Y + + S++ T+F ++ H +++ + + + L Sbjct: 308 KVIPLI----------GEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFL 357 Query: 176 H 176 H Sbjct: 358 H 358 >gi|88702793 slit-like 2 [Homo sapiens] Length = 673 Score = 35.0 bits (79), Expect = 0.073 Identities = 25/55 (45%), Positives = 27/55 (49%), Gaps = 3/55 (5%) Query: 176 HCTGQGRCCPTAPQ-KGNKGPGLTPTHLPGVKEP-EVSAGQMPGPGEAELTGGSE 228 +C +GR A Q KG GPG P L GVK P E G GEA L GSE Sbjct: 597 YCVRRGRAMAAAAQDKGQVGPGAGPLELEGVKVPLEPGPKATEGGGEA-LPSGSE 650 >gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide precursor [Homo sapiens] Length = 517 Score = 33.9 bits (76), Expect = 0.16 Identities = 18/60 (30%), Positives = 33/60 (55%), Gaps = 1/60 (1%) Query: 55 RPSPYVVNFLVPSGILIAIDALSFYLPLES-GNCAPFKMTVLLGYSVFLLMMNDLLPATS 113 +P YV+N + P ++ ++ L +LP ++ G + VLL +VFL ++ +P TS Sbjct: 240 KPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETS 299 >gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon precursor [Homo sapiens] Length = 506 Score = 33.1 bits (74), Expect = 0.28 Identities = 38/162 (23%), Positives = 60/162 (37%), Gaps = 16/162 (9%) Query: 65 VPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVRPH 124 VPS + + +SF++ ES AP + + L + +L T+ + + P Sbjct: 286 VPSSVTTMLSWVSFWIKTES---APARTS---------LGITSVLTMTTLGTFSRKNFPR 333 Query: 125 PSRDQKRGVYFALCLSLMVGSLLETIFITHLLHVAT----TQPLPLPRWLHSLLLHCTGQ 180 S Y A+C +LLE + L++ T + L PR + Sbjct: 334 VSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQTKAHASPKLRHPRINSRAHARTRAR 393 Query: 181 GRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAE 222 R C Q+ +T G + P SA Q P PG E Sbjct: 394 SRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPPSPGSPE 435 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.133 0.420 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,131,818 Number of Sequences: 37866 Number of extensions: 645925 Number of successful extensions: 2270 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 38 Number of HSP's successfully gapped in prelim test: 41 Number of HSP's that attempted gapping in prelim test: 2184 Number of HSP's gapped (non-prelim): 105 length of query: 279 length of database: 18,247,518 effective HSP length: 101 effective length of query: 178 effective length of database: 14,423,052 effective search space: 2567303256 effective search space used: 2567303256 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.