Search of human proteins with 46909587

Search of human proteins with 46909587

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46909587 cAMP-dependent protein kinase catalytic subunit
beta isoform 3 [Homo sapiens]
         (257 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46909587 cAMP-dependent protein kinase catalytic subunit beta...   524   e-149
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ...   519   e-148
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta...   492   e-139
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha...   484   e-137
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph...   461   e-130
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho...   418   e-117
gi|4826948 protein kinase, X-linked [Homo sapiens]                    278   3e-75
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   224   6e-59
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   224   6e-59
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   223   1e-58
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   223   1e-58
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   223   1e-58
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   223   1e-58
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H...   222   3e-58
gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Ho...   222   3e-58
gi|4502023 AKT2 kinase [Homo sapiens]                                 220   8e-58
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]     218   5e-57
gi|62241015 AKT1 kinase [Homo sapiens]                                216   2e-56
gi|62241013 AKT1 kinase [Homo sapiens]                                216   2e-56
gi|62241011 AKT1 kinase [Homo sapiens]                                216   2e-56
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       213   1e-55
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      213   1e-55
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   210   9e-55
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   210   9e-55
gi|4506067 protein kinase C, alpha [Homo sapiens]                     202   2e-52
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           202   3e-52
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           202   3e-52
gi|28557781 protein kinase C, eta [Homo sapiens]                      200   1e-51
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H...   199   2e-51
gi|40254851 protein kinase PKNbeta [Homo sapiens]                     199   2e-51

>gi|46909587 cAMP-dependent protein kinase catalytic subunit beta
           isoform 3 [Homo sapiens]
          Length = 257

 Score =  524 bits (1349), Expect = e-149
 Identities = 257/257 (100%), Positives = 257/257 (100%)

Query: 1   MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
           MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
Sbjct: 1   MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60

Query: 61  VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
           VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
Sbjct: 61  VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120

Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
           MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
Sbjct: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180

Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
           IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
Sbjct: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240

Query: 241 ADQPIQIYEKIVSGKNF 257
           ADQPIQIYEKIVSGKNF
Sbjct: 241 ADQPIQIYEKIVSGKNF 257


>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
           isoform 2 [Homo sapiens]
          Length = 351

 Score =  519 bits (1337), Expect = e-148
 Identities = 255/255 (100%), Positives = 255/255 (100%)

Query: 1   MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
           MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
Sbjct: 1   MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60

Query: 61  VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
           VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
Sbjct: 61  VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120

Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
           MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
Sbjct: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180

Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
           IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
Sbjct: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240

Query: 241 ADQPIQIYEKIVSGK 255
           ADQPIQIYEKIVSGK
Sbjct: 241 ADQPIQIYEKIVSGK 255


>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
           isoform 1 [Homo sapiens]
          Length = 398

 Score =  492 bits (1266), Expect = e-139
 Identities = 240/241 (99%), Positives = 241/241 (100%)

Query: 15  SVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 74
           S+KEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI
Sbjct: 62  SMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKI 121

Query: 75  LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR 134
           LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR
Sbjct: 122 LDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLR 181

Query: 135 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG 194
           RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG
Sbjct: 182 RIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG 241

Query: 195 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
           RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG
Sbjct: 242 RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 301

Query: 255 K 255
           K
Sbjct: 302 K 302


>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  484 bits (1245), Expect = e-137
 Identities = 238/255 (93%), Positives = 244/255 (95%)

Query: 1   MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
           MGNAA AKKGSE ESVKEFLAKAKEDFLKKWE+P QN A L+ FER KTLGTGSFGRVML
Sbjct: 1   MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML 60

Query: 61  VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
           VKHK T  +YAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV+LE++FKDNSNLYMV
Sbjct: 61  VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV 120

Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
           MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID QGY
Sbjct: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY 180

Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
           IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
Sbjct: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240

Query: 241 ADQPIQIYEKIVSGK 255
           ADQPIQIYEKIVSGK
Sbjct: 241 ADQPIQIYEKIVSGK 255


>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 2 [Homo sapiens]
          Length = 343

 Score =  461 bits (1186), Expect = e-130
 Identities = 226/245 (92%), Positives = 232/245 (94%)

Query: 11  SEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYY 70
           S    VKEFLAKAKEDFLKKWE+P QN A L+ FER KTLGTGSFGRVMLVKHK T  +Y
Sbjct: 3   SNSSDVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHY 62

Query: 71  AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMF 130
           AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLV+LE++FKDNSNLYMVMEYVPGGEMF
Sbjct: 63  AMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMF 122

Query: 131 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK 190
           SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID QGYIQVTDFGFAK
Sbjct: 123 SHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAK 182

Query: 191 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 250
           RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK
Sbjct: 183 RVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEK 242

Query: 251 IVSGK 255
           IVSGK
Sbjct: 243 IVSGK 247


>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
           sapiens]
          Length = 351

 Score =  418 bits (1074), Expect = e-117
 Identities = 199/255 (78%), Positives = 226/255 (88%)

Query: 1   MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML 60
           MGNA   K   + ESV EFLAKA+ DFL +W NP QN A  + FER +TLG GSFGRVML
Sbjct: 1   MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML 60

Query: 61  VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV 120
           V+H+ T  +YAMKIL+KQKVVK+KQ+EH LNEKRILQA++FPFLV+L+++FKDNS LY+V
Sbjct: 61  VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV 120

Query: 121 MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY 180
           MEYVPGGEMFS L+R+GRFSEPHA FYAAQ+VL  +YLHSLDLI+RDLKPENLLID QGY
Sbjct: 121 MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY 180

Query: 181 IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
           +QVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMA G+PPF+
Sbjct: 181 LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY 240

Query: 241 ADQPIQIYEKIVSGK 255
           ADQPIQIYEKIVSG+
Sbjct: 241 ADQPIQIYEKIVSGR 255


>gi|4826948 protein kinase, X-linked [Homo sapiens]
          Length = 358

 Score =  278 bits (712), Expect = 3e-75
 Identities = 124/215 (57%), Positives = 169/215 (78%)

Query: 41  LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
           L+DF+   T+GTG+FGRV LVK K  + ++A+K++    V++LKQ +H  NEK +L+ V+
Sbjct: 46  LQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVS 105

Query: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
            PFL+RL + + D   LYM+MEYVPGGE+FS+LR  GRFS     FY+A+I+   EYLHS
Sbjct: 106 HPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHS 165

Query: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAV 220
            +++YRDLKPEN+L+D  G+I++TDFGFAK++  RTWTLCGTPEYLAPE+I SKG+ +AV
Sbjct: 166 KEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAV 225

Query: 221 DWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255
           DWWALG+LI+EM +G+PPFF D P  IY+KI++GK
Sbjct: 226 DWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGK 260


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  224 bits (571), Expect = 6e-59
 Identities = 108/224 (48%), Positives = 154/224 (68%), Gaps = 5/224 (2%)

Query: 34  PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
           P+ N NA   DF+  K +G G++G+V+L K K+   +YA+K+L K+ ++K K+  H + E
Sbjct: 24  PSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAE 83

Query: 93  KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
           + +L + V  PFLV L Y+F+    LY V++YV GGE+F HL+R  RF EP ARFYAA++
Sbjct: 84  RSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEV 143

Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
                YLHSL++IYRDLKPEN+L+D QG++ +TDFG  K     +  T T CGTPEYLAP
Sbjct: 144 ASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAP 203

Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
           E++  + Y++AVDWW LG ++YEM  G PPF++    Q+YE I+
Sbjct: 204 EVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENIL 247


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  224 bits (571), Expect = 6e-59
 Identities = 108/224 (48%), Positives = 154/224 (68%), Gaps = 5/224 (2%)

Query: 34  PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
           P+ N NA   DF+  K +G G++G+V+L K K+   +YA+K+L K+ ++K K+  H + E
Sbjct: 84  PSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAE 143

Query: 93  KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
           + +L + V  PFLV L Y+F+    LY V++YV GGE+F HL+R  RF EP ARFYAA++
Sbjct: 144 RSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEV 203

Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
                YLHSL++IYRDLKPEN+L+D QG++ +TDFG  K     +  T T CGTPEYLAP
Sbjct: 204 ASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAP 263

Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
           E++  + Y++AVDWW LG ++YEM  G PPF++    Q+YE I+
Sbjct: 264 EVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENIL 307


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  223 bits (569), Expect = 1e-58
 Identities = 106/225 (47%), Positives = 155/225 (68%), Gaps = 5/225 (2%)

Query: 34  PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
           P+ N +A   DF   K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 87  PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 146

Query: 93  KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
           + +L + V  PFLV L ++F+    LY V++Y+ GGE+F HL+R   F EP ARFYAA+I
Sbjct: 147 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 206

Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
                YLHSL+++YRDLKPEN+L+D QG+I +TDFG  K        T T CGTPEYLAP
Sbjct: 207 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 266

Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253
           E++  + Y++ VDWW LG ++YEM  G PPF++    ++Y+ I++
Sbjct: 267 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN 311


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  223 bits (569), Expect = 1e-58
 Identities = 106/225 (47%), Positives = 155/225 (68%), Gaps = 5/225 (2%)

Query: 34  PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
           P+ N +A   DF   K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 101 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 160

Query: 93  KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
           + +L + V  PFLV L ++F+    LY V++Y+ GGE+F HL+R   F EP ARFYAA+I
Sbjct: 161 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 220

Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
                YLHSL+++YRDLKPEN+L+D QG+I +TDFG  K        T T CGTPEYLAP
Sbjct: 221 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 280

Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253
           E++  + Y++ VDWW LG ++YEM  G PPF++    ++Y+ I++
Sbjct: 281 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN 325


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  223 bits (569), Expect = 1e-58
 Identities = 106/225 (47%), Positives = 155/225 (68%), Gaps = 5/225 (2%)

Query: 34  PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
           P+ N +A   DF   K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 115 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 174

Query: 93  KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
           + +L + V  PFLV L ++F+    LY V++Y+ GGE+F HL+R   F EP ARFYAA+I
Sbjct: 175 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 234

Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
                YLHSL+++YRDLKPEN+L+D QG+I +TDFG  K        T T CGTPEYLAP
Sbjct: 235 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 294

Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253
           E++  + Y++ VDWW LG ++YEM  G PPF++    ++Y+ I++
Sbjct: 295 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN 339


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  223 bits (569), Expect = 1e-58
 Identities = 106/225 (47%), Positives = 155/225 (68%), Gaps = 5/225 (2%)

Query: 34  PTQN-NAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
           P+ N +A   DF   K +G GSFG+V+L +HKA E +YA+K+L K+ ++K K+ +H ++E
Sbjct: 182 PSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE 241

Query: 93  KRIL-QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQI 151
           + +L + V  PFLV L ++F+    LY V++Y+ GGE+F HL+R   F EP ARFYAA+I
Sbjct: 242 RNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEI 301

Query: 152 VLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAP 208
                YLHSL+++YRDLKPEN+L+D QG+I +TDFG  K        T T CGTPEYLAP
Sbjct: 302 ASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAP 361

Query: 209 EIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253
           E++  + Y++ VDWW LG ++YEM  G PPF++    ++Y+ I++
Sbjct: 362 EVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN 406


>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
           sapiens]
          Length = 671

 Score =  222 bits (565), Expect = 3e-58
 Identities = 111/220 (50%), Positives = 152/220 (69%), Gaps = 3/220 (1%)

Query: 38  NAGLEDFERKKTLGTGSFGRVMLVKHKATE-QYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
           N  L DF    TLG G FGRV LV+ K+ E + +AMKIL K+ +V  +Q EH  +EK+I+
Sbjct: 354 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 413

Query: 97  QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
           Q  +  F+VRL   FKD+  LYM+ME   GGE+++ LR  G F +   RFY A +V  F 
Sbjct: 414 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 473

Query: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSK 214
           YLHS  +IYRDLKPENL++DH+GY ++ DFGFAK++    +TWT CGTPEY+APEIIL+K
Sbjct: 474 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 533

Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
           G++ + D+W+LG+L+YE+  G PPF    P++ Y  I+ G
Sbjct: 534 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRG 573


>gi|10835242 protein kinase, cGMP-dependent, type I isoform 2 [Homo
           sapiens]
          Length = 686

 Score =  222 bits (565), Expect = 3e-58
 Identities = 111/220 (50%), Positives = 152/220 (69%), Gaps = 3/220 (1%)

Query: 38  NAGLEDFERKKTLGTGSFGRVMLVKHKATE-QYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
           N  L DF    TLG G FGRV LV+ K+ E + +AMKIL K+ +V  +Q EH  +EK+I+
Sbjct: 369 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 428

Query: 97  QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
           Q  +  F+VRL   FKD+  LYM+ME   GGE+++ LR  G F +   RFY A +V  F 
Sbjct: 429 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFA 488

Query: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSK 214
           YLHS  +IYRDLKPENL++DH+GY ++ DFGFAK++    +TWT CGTPEY+APEIIL+K
Sbjct: 489 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 548

Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
           G++ + D+W+LG+L+YE+  G PPF    P++ Y  I+ G
Sbjct: 549 GHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRG 588


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  220 bits (561), Expect = 8e-58
 Identities = 107/215 (49%), Positives = 145/215 (67%), Gaps = 3/215 (1%)

Query: 41  LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
           + DF+  K LG G+FG+V+LV+ KAT +YYAMKIL K+ ++   ++ HT+ E R+LQ   
Sbjct: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTR 208

Query: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
            PFL  L+YAF+ +  L  VMEY  GGE+F HL R   F+E  ARFY A+IV   EYLHS
Sbjct: 209 HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHS 268

Query: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYN 217
            D++YRD+K ENL++D  G+I++TDFG  K     G T  T CGTPEYLAPE++    Y 
Sbjct: 269 RDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYG 328

Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
           +AVDWW LGV++YEM  G  PF+     +++E I+
Sbjct: 329 RAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 363


>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
          Length = 762

 Score =  218 bits (554), Expect = 5e-57
 Identities = 105/220 (47%), Positives = 151/220 (68%), Gaps = 2/220 (0%)

Query: 37  NNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL 96
           +++  ++ E   TLG G FGRV LVK K     +AMK + K+ +V  KQ EH  +EKRIL
Sbjct: 446 SSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRIL 505

Query: 97  QAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 156
           + +  PF+V+L   FKDN  +YM++E   GGE++S LR  G F EP ++F  A +   F+
Sbjct: 506 EELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFD 565

Query: 157 YLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSK 214
           YLH L +IYRDLKPENL++D +GY+++ DFGFAK++    +TWT CGTPEY+APE+IL+K
Sbjct: 566 YLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNK 625

Query: 215 GYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG 254
           G++ +VD+W+LG+L+YE+  G PPF     +  Y  I+ G
Sbjct: 626 GHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKG 665


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  216 bits (550), Expect = 2e-56
 Identities = 116/260 (44%), Positives = 160/260 (61%), Gaps = 20/260 (7%)

Query: 13  VESVKEFLAKAKEDFLKKWENPTQNNAGLED----------------FERKKTLGTGSFG 56
           +++V + L K +E+ +        +N+G E+                FE  K LG G+FG
Sbjct: 103 IQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFG 162

Query: 57  RVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSN 116
           +V+LVK KAT +YYAMKIL K+ +V   ++ HTL E R+LQ    PFL  L+Y+F+ +  
Sbjct: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222

Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLI 175
           L  VMEY  GGE+F HL R   FSE  ARFY A+IV   +YLHS  +++YRDLK ENL++
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282

Query: 176 DHQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232
           D  G+I++TDFG  K     G T  T CGTPEYLAPE++    Y +AVDWW LGV++YEM
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342

Query: 233 AAGYPPFFADQPIQIYEKIV 252
             G  PF+     +++E I+
Sbjct: 343 MCGRLPFYNQDHEKLFELIL 362


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  216 bits (550), Expect = 2e-56
 Identities = 116/260 (44%), Positives = 160/260 (61%), Gaps = 20/260 (7%)

Query: 13  VESVKEFLAKAKEDFLKKWENPTQNNAGLED----------------FERKKTLGTGSFG 56
           +++V + L K +E+ +        +N+G E+                FE  K LG G+FG
Sbjct: 103 IQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFG 162

Query: 57  RVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSN 116
           +V+LVK KAT +YYAMKIL K+ +V   ++ HTL E R+LQ    PFL  L+Y+F+ +  
Sbjct: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222

Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLI 175
           L  VMEY  GGE+F HL R   FSE  ARFY A+IV   +YLHS  +++YRDLK ENL++
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282

Query: 176 DHQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232
           D  G+I++TDFG  K     G T  T CGTPEYLAPE++    Y +AVDWW LGV++YEM
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342

Query: 233 AAGYPPFFADQPIQIYEKIV 252
             G  PF+     +++E I+
Sbjct: 343 MCGRLPFYNQDHEKLFELIL 362


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  216 bits (550), Expect = 2e-56
 Identities = 116/260 (44%), Positives = 160/260 (61%), Gaps = 20/260 (7%)

Query: 13  VESVKEFLAKAKEDFLKKWENPTQNNAGLED----------------FERKKTLGTGSFG 56
           +++V + L K +E+ +        +N+G E+                FE  K LG G+FG
Sbjct: 103 IQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFG 162

Query: 57  RVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSN 116
           +V+LVK KAT +YYAMKIL K+ +V   ++ HTL E R+LQ    PFL  L+Y+F+ +  
Sbjct: 163 KVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDR 222

Query: 117 LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLI 175
           L  VMEY  GGE+F HL R   FSE  ARFY A+IV   +YLHS  +++YRDLK ENL++
Sbjct: 223 LCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLML 282

Query: 176 DHQGYIQVTDFGFAKR--VKGRTW-TLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEM 232
           D  G+I++TDFG  K     G T  T CGTPEYLAPE++    Y +AVDWW LGV++YEM
Sbjct: 283 DKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 342

Query: 233 AAGYPPFFADQPIQIYEKIV 252
             G  PF+     +++E I+
Sbjct: 343 MCGRLPFYNQDHEKLFELIL 362


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  213 bits (543), Expect = 1e-55
 Identities = 103/215 (47%), Positives = 141/215 (65%), Gaps = 3/215 (1%)

Query: 41  LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
           + DF+  K LG G+FG+V+LV+ KA+ +YYAMKIL K+ ++   ++ HTL E R+L+   
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR 204

Query: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
            PFL  L+Y+F+    L  VMEYV GGE+F HL R   FSE   RFY A+IV   +YLHS
Sbjct: 205 HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS 264

Query: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYN 217
             ++YRDLK ENL++D  G+I++TDFG  K          T CGTPEYLAPE++    Y 
Sbjct: 265 GKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYG 324

Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
           +AVDWW LGV++YEM  G  PF+     +++E I+
Sbjct: 325 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 359


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  213 bits (543), Expect = 1e-55
 Identities = 103/215 (47%), Positives = 141/215 (65%), Gaps = 3/215 (1%)

Query: 41  LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
           + DF+  K LG G+FG+V+LV+ KA+ +YYAMKIL K+ ++   ++ HTL E R+L+   
Sbjct: 145 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR 204

Query: 101 FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHS 160
            PFL  L+Y+F+    L  VMEYV GGE+F HL R   FSE   RFY A+IV   +YLHS
Sbjct: 205 HPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS 264

Query: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYN 217
             ++YRDLK ENL++D  G+I++TDFG  K          T CGTPEYLAPE++    Y 
Sbjct: 265 GKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYG 324

Query: 218 KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
           +AVDWW LGV++YEM  G  PF+     +++E I+
Sbjct: 325 RAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELIL 359


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  210 bits (535), Expect = 9e-55
 Identities = 99/214 (46%), Positives = 142/214 (66%), Gaps = 4/214 (1%)

Query: 43  DFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL-QAVNF 101
           DF+  K +G GSFG+V+L K K   ++YA+K+L K+ V+  K+ +H + E+ +L + V  
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
           PFLV L Y+F+    LY V+++V GGE+F HL+R   F E  ARFYAA+I     YLHS+
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 162 DLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNK 218
            ++YRDLKPEN+L+D  G++ +TDFG  K    +   T T CGTPEYLAPE+I  + Y+ 
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340

Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
            VDWW LG ++YEM  G PPF+     ++Y+ I+
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNIL 374


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  210 bits (535), Expect = 9e-55
 Identities = 99/214 (46%), Positives = 142/214 (66%), Gaps = 4/214 (1%)

Query: 43  DFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRIL-QAVNF 101
           DF+  K +G GSFG+V+L K K   ++YA+K+L K+ V+  K+ +H + E+ +L + V  
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
           PFLV L Y+F+    LY V+++V GGE+F HL+R   F E  ARFYAA+I     YLHS+
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 162 DLIYRDLKPENLLIDHQGYIQVTDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNK 218
            ++YRDLKPEN+L+D  G++ +TDFG  K    +   T T CGTPEYLAPE+I  + Y+ 
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340

Query: 219 AVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
            VDWW LG ++YEM  G PPF+     ++Y+ I+
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNIL 374


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  202 bits (515), Expect = 2e-52
 Identities = 101/216 (46%), Positives = 144/216 (66%), Gaps = 4/216 (1%)

Query: 41  LEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVN 100
           L DF     LG GSFG+VML   K TE+ YA+KIL K  V++   +E T+ EKR+L  ++
Sbjct: 336 LTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLD 395

Query: 101 FP-FLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159
            P FL +L   F+    LY VMEYV GG++  H++++G+F EP A FYAA+I +   +LH
Sbjct: 396 KPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLH 455

Query: 160 SLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEIILSKGY 216
              +IYRDLK +N+++D +G+I++ DFG  K   + G  T T CGTP+Y+APEII  + Y
Sbjct: 456 KRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPY 515

Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
            K+VDWWA GVL+YEM AG PPF  +   ++++ I+
Sbjct: 516 GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIM 551


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  202 bits (513), Expect = 3e-52
 Identities = 107/252 (42%), Positives = 154/252 (61%), Gaps = 9/252 (3%)

Query: 5   ATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHK 64
           A   +G++V   K     +K D      N  ++   L DF     LG GSFG+VML + K
Sbjct: 308 AKISQGTKVPEEKTTNTVSKFD-----NNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERK 362

Query: 65  ATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP-FLVRLEYAFKDNSNLYMVMEY 123
            T++ YA+KIL K  V++   +E T+ EKR+L     P FL +L   F+    LY VMEY
Sbjct: 363 GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEY 422

Query: 124 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQV 183
           V GG++  H++++GRF EPHA FYAA+I +   +L S  +IYRDLK +N+++D +G+I++
Sbjct: 423 VNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI 482

Query: 184 TDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
            DFG  K        T T CGTP+Y+APEII  + Y K+VDWWA GVL+YEM AG  PF 
Sbjct: 483 ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542

Query: 241 ADQPIQIYEKIV 252
            +   ++++ I+
Sbjct: 543 GEDEDELFQSIM 554


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  202 bits (513), Expect = 3e-52
 Identities = 107/252 (42%), Positives = 154/252 (61%), Gaps = 9/252 (3%)

Query: 5   ATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHK 64
           A   +G++V   K     +K D      N  ++   L DF     LG GSFG+VML + K
Sbjct: 308 AKISQGTKVPEEKTTNTVSKFD-----NNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERK 362

Query: 65  ATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFP-FLVRLEYAFKDNSNLYMVMEY 123
            T++ YA+KIL K  V++   +E T+ EKR+L     P FL +L   F+    LY VMEY
Sbjct: 363 GTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEY 422

Query: 124 VPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQV 183
           V GG++  H++++GRF EPHA FYAA+I +   +L S  +IYRDLK +N+++D +G+I++
Sbjct: 423 VNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI 482

Query: 184 TDFGFAKR---VKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 240
            DFG  K        T T CGTP+Y+APEII  + Y K+VDWWA GVL+YEM AG  PF 
Sbjct: 483 ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE 542

Query: 241 ADQPIQIYEKIV 252
            +   ++++ I+
Sbjct: 543 GEDEDELFQSIM 554


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  200 bits (508), Expect = 1e-51
 Identities = 100/223 (44%), Positives = 145/223 (65%), Gaps = 4/223 (1%)

Query: 35  TQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKR 94
           + N  G+++FE  + LG GSFG+VML + K T   YA+K+L K  +++   +E T+ EKR
Sbjct: 346 SSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKR 405

Query: 95  ILQ-AVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVL 153
           IL  A N PFL +L   F+    L+ VME+V GG++  H+++  RF E  ARFYAA+I+ 
Sbjct: 406 ILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIIS 465

Query: 154 TFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR--VKG-RTWTLCGTPEYLAPEI 210
              +LH   +IYRDLK +N+L+DH+G+ ++ DFG  K     G  T T CGTP+Y+APEI
Sbjct: 466 ALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEI 525

Query: 211 ILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253
           +    Y  AVDWWA+GVL+YEM  G+ PF A+    ++E I++
Sbjct: 526 LQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN 568


>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
           sapiens]
          Length = 482

 Score =  199 bits (507), Expect = 2e-51
 Identities = 103/219 (47%), Positives = 143/219 (65%), Gaps = 7/219 (3%)

Query: 44  FERKKTLGTGSFGRVMLV-KHKATE--QYYAMKILDKQKVVK-LKQIEHTLNEKRILQAV 99
           FE  + LG G +G+V  V K + T   + YAMK+L K K+V+  K   HT  E+ IL++V
Sbjct: 67  FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESV 126

Query: 100 NFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLH 159
             PF+V L YAF+    LY+++E + GGE+F+HL R G F E  A FY A+I L   +LH
Sbjct: 127 KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH 186

Query: 160 SLDLIYRDLKPENLLIDHQGYIQVTDFGFAK---RVKGRTWTLCGTPEYLAPEIILSKGY 216
           S  +IYRDLKPEN+++  QG+I++TDFG  K        T T CGT EY+APEI++  G+
Sbjct: 187 SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGH 246

Query: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGK 255
           N+AVDWW+LG L+Y+M  G PPF A+   +  +KI+ GK
Sbjct: 247 NRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGK 285


>gi|40254851 protein kinase PKNbeta [Homo sapiens]
          Length = 889

 Score =  199 bits (506), Expect = 2e-51
 Identities = 104/227 (45%), Positives = 145/227 (63%), Gaps = 7/227 (3%)

Query: 33  NPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNE 92
           +PT+    L+DF     LG G FG+V+LV+ K T +YYA+K L KQ+V+   +IE    E
Sbjct: 548 SPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCE 607

Query: 93  KRILQAVN---FPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA 149
           KRIL+AV     PFL+ L   F+ +S+   V E+VPGG++   +     F EP ARFY A
Sbjct: 608 KRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHE-DVFPEPQARFYVA 666

Query: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG---RTWTLCGTPEYL 206
            +VL  ++LH   +IYRDLK +NLL+D QG++++ DFG  K   G   RT T CGTPE+L
Sbjct: 667 CVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFL 726

Query: 207 APEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVS 253
           APE++  + Y +AVDWW LGVL+YEM  G  PF  D   ++++ IV+
Sbjct: 727 APEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVN 773


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,519,389
Number of Sequences: 37866
Number of extensions: 406843
Number of successful extensions: 3061
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 719
Number of HSP's successfully gapped in prelim test: 80
Number of HSP's that attempted gapping in prelim test: 875
Number of HSP's gapped (non-prelim): 881
length of query: 257
length of database: 18,247,518
effective HSP length: 100
effective length of query: 157
effective length of database: 14,460,918
effective search space: 2270364126
effective search space used: 2270364126
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.