Search of human proteins with 46249359

Search of human proteins with 46249359

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|46249359 membrane-spanning 4-domains, subfamily A, member 7
isoform 2 [Homo sapiens]
         (195 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|46249347 membrane-spanning 4-domains, subfamily A, member 7 i...   387   e-108
gi|46249359 membrane-spanning 4-domains, subfamily A, member 7 i...   387   e-108
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i...   365   e-101
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i...   365   e-101
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ...    77   7e-15
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ...    77   1e-14
gi|21264311 membrane-spanning 4-domains, subfamily A, member 6E ...    60   2e-09
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i...    43   2e-04
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i...    43   2e-04
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A...    42   3e-04
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A...    42   3e-04
gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A...    42   3e-04
gi|4503677 membrane-spanning 4-domains, subfamily A, member 2 is...    36   0.024
gi|73486653 membrane-spanning 4-domains, subfamily A, member 3 i...    35   0.031
gi|8923206 membrane-spanning 4-domains, subfamily A, member 12 [...    35   0.053
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ...    33   0.12 
gi|214831008 membrane-spanning 4-domains, subfamily A, member 2 ...    32   0.34 
gi|223972670 thyrotrophic embryonic factor isoform 2 [Homo sapiens]    30   1.00 
gi|4507431 thyrotrophic embryonic factor isoform 1 [Homo sapiens]      30   1.00 
gi|21361103 solute carrier family 25, member 12 [Homo sapiens]         30   1.3  
gi|23110997 membrane-spanning 4-domains, subfamily A, member 5 [...    30   1.7  
gi|169202868 PREDICTED: similar to membrane-spanning 4-domains, ...    29   2.2  
gi|169203526 PREDICTED: similar to membrane-spanning 4-domains, ...    29   2.2  
gi|169202217 PREDICTED: similar to membrane-spanning 4-domains, ...    29   2.2  
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i...    29   2.2  
gi|9845297 diablo isoform 1 precursor [Homo sapiens]                   28   4.9  
gi|149588599 membrane-spanning 4-domains, subfamily A, member 15...    28   4.9  
gi|22749421 membrane-spanning 4-domains, subfamily A, member 15 ...    28   4.9  

>gi|46249347 membrane-spanning 4-domains, subfamily A, member 7
           isoform 2 [Homo sapiens]
          Length = 195

 Score =  387 bits (994), Expect = e-108
 Identities = 195/195 (100%), Positives = 195/195 (100%)

Query: 1   MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGFGITGSLSIIS 60
           MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGFGITGSLSIIS
Sbjct: 1   MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGFGITGSLSIIS 60

Query: 61  GKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYY 120
           GKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYY
Sbjct: 61  GKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYY 120

Query: 121 YPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQ 180
           YPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQ
Sbjct: 121 YPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQ 180

Query: 181 DHIQQVKKSSSRSWI 195
           DHIQQVKKSSSRSWI
Sbjct: 181 DHIQQVKKSSSRSWI 195


>gi|46249359 membrane-spanning 4-domains, subfamily A, member 7
           isoform 2 [Homo sapiens]
          Length = 195

 Score =  387 bits (994), Expect = e-108
 Identities = 195/195 (100%), Positives = 195/195 (100%)

Query: 1   MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGFGITGSLSIIS 60
           MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGFGITGSLSIIS
Sbjct: 1   MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGFGITGSLSIIS 60

Query: 61  GKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYY 120
           GKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYY
Sbjct: 61  GKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYY 120

Query: 121 YPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQ 180
           YPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQ
Sbjct: 121 YPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQ 180

Query: 181 DHIQQVKKSSSRSWI 195
           DHIQQVKKSSSRSWI
Sbjct: 181 DHIQQVKKSSSRSWI 195


>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
           isoform 1 [Homo sapiens]
          Length = 240

 Score =  365 bits (938), Expect = e-101
 Identities = 195/240 (81%), Positives = 195/240 (81%), Gaps = 45/240 (18%)

Query: 1   MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLG----------- 49
           MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLG           
Sbjct: 1   MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS 60

Query: 50  ----------------------------------FGITGSLSIISGKQSTKPFDLSSLTS 75
                                             FGITGSLSIISGKQSTKPFDLSSLTS
Sbjct: 61  SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS 120

Query: 76  NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 135
           NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS
Sbjct: 121 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 180

Query: 136 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 195
           LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI
Sbjct: 181 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 240


>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
           isoform 1 [Homo sapiens]
          Length = 240

 Score =  365 bits (938), Expect = e-101
 Identities = 195/240 (81%), Positives = 195/240 (81%), Gaps = 45/240 (18%)

Query: 1   MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLG----------- 49
           MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLG           
Sbjct: 1   MLLQSQTMGVSHSFTPKGITIPQREKPGHMYQNEDYLQNGLPTETTVLGTVQILCCLLIS 60

Query: 50  ----------------------------------FGITGSLSIISGKQSTKPFDLSSLTS 75
                                             FGITGSLSIISGKQSTKPFDLSSLTS
Sbjct: 61  SLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGSLSIISGKQSTKPFDLSSLTS 120

Query: 76  NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 135
           NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS
Sbjct: 121 NAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVS 180

Query: 136 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 195
           LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI
Sbjct: 181 LTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNNPGSSFSSTQSQDHIQQVKKSSSRSWI 240


>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
           isoform 1 [Homo sapiens]
          Length = 248

 Score = 77.4 bits (189), Expect = 7e-15
 Identities = 48/125 (38%), Positives = 69/125 (55%), Gaps = 3/125 (2%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F I+GSLSI + K+ TK    SSL  + +S+++A  G  +L+     L  AS  C  + +
Sbjct: 95  FIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKN 154

Query: 110 YLSSLPYSEYYY--PIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYS 167
            + +  Y  Y+Y   +Y   DC     SL G L +MLI T+LE  LA  ++V  WKQ YS
Sbjct: 155 NIPTRSYVSYFYHDSLYTT-DCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYS 213

Query: 168 NNPGS 172
           + PGS
Sbjct: 214 DFPGS 218


>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
           isoform 2 [Homo sapiens]
          Length = 225

 Score = 76.6 bits (187), Expect = 1e-14
 Identities = 48/126 (38%), Positives = 69/126 (54%), Gaps = 3/126 (2%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F I+GSLSI + K+ TK    SSL  + +S+++A  G  +L+     L  AS  C  + +
Sbjct: 95  FIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKN 154

Query: 110 YLSSLPYSEYYY--PIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYS 167
            + +  Y  Y+Y   +Y   DC     SL G L +MLI T+LE  LA  ++V  WKQ YS
Sbjct: 155 NIPTRSYVSYFYHDSLYTT-DCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYS 213

Query: 168 NNPGSS 173
           + PG S
Sbjct: 214 DFPGVS 219


>gi|21264311 membrane-spanning 4-domains, subfamily A, member 6E
           [Homo sapiens]
          Length = 147

 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 48/147 (32%), Positives = 66/147 (44%), Gaps = 21/147 (14%)

Query: 19  ITIPQREKPGHMYQNEDYLQNGLPTETTVLGFGITGSLSIISGKQSTKPFDLSSLTSNAV 78
           I   Q EKP    Q +D L+  L  +  V+G                     SSL  + +
Sbjct: 19  INFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVH-------------------SSLAGSIL 59

Query: 79  SSVTAGAGLFLLADSMVALRTASQHCG-SEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLT 137
           S+++A  G  LL+ +  AL  AS  C   E D  + L  S  Y+  Y + DC     SL 
Sbjct: 60  SALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTM-DCHRAKASLA 118

Query: 138 GVLVVMLIFTVLELLLAAYSSVFWWKQ 164
           G L +ML+ TVLE  LA  ++V  WKQ
Sbjct: 119 GTLSLMLVSTVLEFCLAVLTAVLQWKQ 145


>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
           isoform a [Homo sapiens]
          Length = 220

 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 41/136 (30%), Positives = 58/136 (42%), Gaps = 17/136 (12%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F I+GSLSI +G ++TK     SL  N  SSV A +G+ +   S+               
Sbjct: 92  FIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAF------------- 138

Query: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNN 169
           Y    PY  YY       +C  T   L G+  ++L+ +VLE  +A   S F  K L    
Sbjct: 139 YSFHHPYCNYY---GNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC-T 194

Query: 170 PGSSFSSTQSQDHIQQ 185
           PG       S  H+ +
Sbjct: 195 PGGVVLILPSHSHMAE 210


>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
           isoform b [Homo sapiens]
          Length = 239

 Score = 42.7 bits (99), Expect = 2e-04
 Identities = 41/136 (30%), Positives = 58/136 (42%), Gaps = 17/136 (12%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F I+GSLSI +G ++TK     SL  N  SSV A +G+ +   S+               
Sbjct: 111 FIISGSLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTFSLAF------------- 157

Query: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNN 169
           Y    PY  YY       +C  T   L G+  ++L+ +VLE  +A   S F  K L    
Sbjct: 158 YSFHHPYCNYY---GNSNNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFGCKVLCC-T 213

Query: 170 PGSSFSSTQSQDHIQQ 185
           PG       S  H+ +
Sbjct: 214 PGGVVLILPSHSHMAE 229


>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
           member 4E isoform 1 [Homo sapiens]
          Length = 243

 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 17/137 (12%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F I+ SLS+ +G ++TK     SL  N  SSV A +G+ + A S+        +C    D
Sbjct: 115 FIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNH--D 172

Query: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNN 169
            LSS              +C +T   L G   ++L+ +VLE  +A   S F  K L   +
Sbjct: 173 QLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVSLSAFGCKVLCC-S 217

Query: 170 PGSSFSSTQSQDHIQQV 186
           P      T S  H+ ++
Sbjct: 218 PSEVVLITPSNSHMAEI 234


>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
           member 4E isoform 3 [Homo sapiens]
          Length = 243

 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 17/137 (12%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F I+ SLS+ +G ++TK     SL  N  SSV A +G+ + A S+        +C    D
Sbjct: 115 FIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNH--D 172

Query: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNN 169
            LSS              +C +T   L G   ++L+ +VLE  +A   S F  K L   +
Sbjct: 173 QLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVSLSAFGCKVLCC-S 217

Query: 170 PGSSFSSTQSQDHIQQV 186
           P      T S  H+ ++
Sbjct: 218 PSEVVLITPSNSHMAEI 234


>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
           member 4E isoform 3 [Homo sapiens]
          Length = 243

 Score = 42.4 bits (98), Expect = 3e-04
 Identities = 40/137 (29%), Positives = 61/137 (44%), Gaps = 17/137 (12%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F I+ SLS+ +G ++TK     SL  N  SSV A +G+ + A S+        +C    D
Sbjct: 115 FIISVSLSVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISLTFYSFRYHYCNH--D 172

Query: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFWWKQLYSNN 169
            LSS              +C +T   L G   ++L+ +VLE  +A   S F  K L   +
Sbjct: 173 QLSS--------------NCYMTMSILMGTDGMVLLLSVLEFCIAVALSAFGCKVLCC-S 217

Query: 170 PGSSFSSTQSQDHIQQV 186
           P      T S  H+ ++
Sbjct: 218 PSEVVLITPSNSHMAEI 234


>gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
           isoform 1 [Homo sapiens]
          Length = 244

 Score = 35.8 bits (81), Expect = 0.024
 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 20/104 (19%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F I+G LSIIS +++       SL +N  SS+  G G+ +L                 ++
Sbjct: 108 FSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILI----------------IN 151

Query: 110 YLSSLPYSEYY--YPIYEIKDCLLTSVSLTGVLVVMLIFTVLEL 151
              SL Y   +     +E K C + S S T ++V+ML  T+L L
Sbjct: 152 LKKSLAYIHIHSCQKFFETK-CFMASFS-TEIVVMMLFLTILGL 193


>gi|73486653 membrane-spanning 4-domains, subfamily A, member 3
           isoform b [Homo sapiens]
          Length = 168

 Score = 35.4 bits (80), Expect = 0.031
 Identities = 31/132 (23%), Positives = 59/132 (44%), Gaps = 15/132 (11%)

Query: 30  MYQNEDYLQNGLPTETTVLGFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFL 89
           +YQ  D   +    +  VLGF  +G+LS+++G + T+ +  +S   N  S+  A  G   
Sbjct: 33  VYQPIDGSPDYQKAKLQVLGFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAF 92

Query: 90  LADSMVALRTASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVL 149
           L+ ++     + + C S  +      Y              + S+S  G++ ++LI T+L
Sbjct: 93  LSLNIAVNIQSLRSCHSSSESPDLCNY--------------MGSIS-NGMVSLLLILTLL 137

Query: 150 ELLLAAYSSVFW 161
           EL +   +   W
Sbjct: 138 ELCVTISTIAMW 149


>gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
           [Homo sapiens]
          Length = 267

 Score = 34.7 bits (78), Expect = 0.053
 Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 26/113 (23%)

Query: 48  LGFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSE 107
           L F I+GSLS+ + K+ ++     SL  N VSS+ A  G+ LL   M     A Q     
Sbjct: 137 LSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDMCINGVAGQ----- 191

Query: 108 MDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVF 160
            DY + L                    S  G+   ++IF++LE  +A  ++ F
Sbjct: 192 -DYWAVL--------------------SGKGISATLMIFSLLEFFVACATAHF 223


>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
           isoform 3 [Homo sapiens]
          Length = 178

 Score = 33.5 bits (75), Expect = 0.12
 Identities = 22/60 (36%), Positives = 32/60 (53%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F I+GSLSI + K+ TK    SSL  + +S+++A  G  +L+     L  AS    S  D
Sbjct: 95  FIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQWNSLSD 154


>gi|214831008 membrane-spanning 4-domains, subfamily A, member 2
           isoform 2 [Homo sapiens]
          Length = 195

 Score = 32.0 bits (71), Expect = 0.34
 Identities = 16/41 (39%), Positives = 24/41 (58%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 90
           F I+G LSIIS +++       SL +N  SS+  G G+ +L
Sbjct: 108 FSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITIL 148


>gi|223972670 thyrotrophic embryonic factor isoform 2 [Homo sapiens]
          Length = 273

 Score = 30.4 bits (67), Expect = 1.00
 Identities = 28/84 (33%), Positives = 40/84 (47%), Gaps = 10/84 (11%)

Query: 5   SQTMGVSHSFTPK--GITIPQREKPGH---MYQNEDYLQNGLPTETTVLGFGITGSLSII 59
           + TM VS S  P     TIP   +  H   M  +E  L+NG+P   T L   +   ++ +
Sbjct: 39  ASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAEL 98

Query: 60  SGKQSTKPFDLSSLTSNAVSSVTA 83
            GK+S      SS T++  SS TA
Sbjct: 99  EGKESA-----SSSTASPPSSSTA 117


>gi|4507431 thyrotrophic embryonic factor isoform 1 [Homo sapiens]
          Length = 303

 Score = 30.4 bits (67), Expect = 1.00
 Identities = 28/84 (33%), Positives = 40/84 (47%), Gaps = 10/84 (11%)

Query: 5   SQTMGVSHSFTPK--GITIPQREKPGH---MYQNEDYLQNGLPTETTVLGFGITGSLSII 59
           + TM VS S  P     TIP   +  H   M  +E  L+NG+P   T L   +   ++ +
Sbjct: 69  ASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAEL 128

Query: 60  SGKQSTKPFDLSSLTSNAVSSVTA 83
            GK+S      SS T++  SS TA
Sbjct: 129 EGKESA-----SSSTASPPSSSTA 147


>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
          Length = 678

 Score = 30.0 bits (66), Expect = 1.3
 Identities = 19/84 (22%), Positives = 36/84 (42%), Gaps = 5/84 (5%)

Query: 41  LPTETTVLGFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTA 100
           +P    VL  G  G   +I     T P ++  +       +T G  +  L + +  L   
Sbjct: 424 VPLPAEVLAGGCAGGSQVIF----TNPLEIVKIRLQVAGEITTGPRVSAL-NVLRDLGIF 478

Query: 101 SQHCGSEMDYLSSLPYSEYYYPIY 124
             + G++  +L  +P+S  Y+P+Y
Sbjct: 479 GLYKGAKACFLRDIPFSAIYFPVY 502


>gi|23110997 membrane-spanning 4-domains, subfamily A, member 5
           [Homo sapiens]
          Length = 200

 Score = 29.6 bits (65), Expect = 1.7
 Identities = 27/121 (22%), Positives = 57/121 (47%), Gaps = 19/121 (15%)

Query: 39  NGLPTETTVLGFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALR 98
           +G P   +VL F  +G+  I   +++T+   + S   N +S++ A AG+ LL    +   
Sbjct: 85  SGYPFWGSVL-FINSGAFLIAVKRKTTETLIILSRIMNFLSALGAIAGIILLTFGFIL-- 141

Query: 99  TASQHCGSEMDYLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSS 158
                   + +Y+    YS      ++   C   +V   G+L+ ++ F+++EL ++   S
Sbjct: 142 --------DQNYICG--YS------HQNSQCKAVTVLFLGILITLMTFSIIELFISLPFS 185

Query: 159 V 159
           +
Sbjct: 186 I 186


>gi|169202868 PREDICTED: similar to membrane-spanning 4-domains,
           subfamily A, member 8B [Homo sapiens]
          Length = 391

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 14/43 (32%), Positives = 28/43 (65%)

Query: 48  LGFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 90
           L + ++GSLS+ + K  +     SS++ N +S++ A AG+F++
Sbjct: 187 LSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFII 229


>gi|169203526 PREDICTED: similar to membrane-spanning 4-domains,
           subfamily A, member 8B [Homo sapiens]
          Length = 391

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 14/43 (32%), Positives = 28/43 (65%)

Query: 48  LGFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 90
           L + ++GSLS+ + K  +     SS++ N +S++ A AG+F++
Sbjct: 187 LSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFII 229


>gi|169202217 PREDICTED: similar to membrane-spanning 4-domains,
           subfamily A, member 8B [Homo sapiens]
          Length = 391

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 14/43 (32%), Positives = 28/43 (65%)

Query: 48  LGFGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 90
           L + ++GSLS+ + K  +     SS++ N +S++ A AG+F++
Sbjct: 187 LSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFII 229


>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
           isoform a [Homo sapiens]
          Length = 214

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 25/112 (22%), Positives = 50/112 (44%), Gaps = 15/112 (13%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109
           F  +G+LS+++G + T+ +  +S   N  S+  A  G   L+ ++     + + C S  +
Sbjct: 99  FCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSE 158

Query: 110 YLSSLPYSEYYYPIYEIKDCLLTSVSLTGVLVVMLIFTVLELLLAAYSSVFW 161
                 Y              + S+S  G++ ++LI T+LEL +   +   W
Sbjct: 159 SPDLCNY--------------MGSIS-NGMVSLLLILTLLELCVTISTIAMW 195


>gi|9845297 diablo isoform 1 precursor [Homo sapiens]
          Length = 239

 Score = 28.1 bits (61), Expect = 4.9
 Identities = 19/62 (30%), Positives = 30/62 (48%), Gaps = 4/62 (6%)

Query: 44  ETTVLGFGITGSLSIISGKQSTKPFDLSS--LTSNAVSSVTAGAGLFLLADSMVALRTAS 101
           +T  +GFG+T  L  +   Q ++P  LSS  L   AVS VT     FL   +   +   +
Sbjct: 44  KTVTIGFGVT--LCAVPIAQKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAIT 101

Query: 102 QH 103
           ++
Sbjct: 102 EY 103


>gi|149588599 membrane-spanning 4-domains, subfamily A, member 15
           isoform 1 [Homo sapiens]
          Length = 240

 Score = 28.1 bits (61), Expect = 4.9
 Identities = 17/41 (41%), Positives = 24/41 (58%)

Query: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 90
           F I+GSLS+ + K  T     SSL +N +S + A AG  +L
Sbjct: 117 FIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAIL 157


>gi|22749421 membrane-spanning 4-domains, subfamily A, member 15
          isoform 2 [Homo sapiens]
          Length = 147

 Score = 28.1 bits (61), Expect = 4.9
 Identities = 17/41 (41%), Positives = 24/41 (58%)

Query: 50 FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLL 90
          F I+GSLS+ + K  T     SSL +N +S + A AG  +L
Sbjct: 24 FIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAIL 64


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.129    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,608,231
Number of Sequences: 37866
Number of extensions: 249911
Number of successful extensions: 667
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 634
Number of HSP's gapped (non-prelim): 35
length of query: 195
length of database: 18,247,518
effective HSP length: 97
effective length of query: 98
effective length of database: 14,574,516
effective search space: 1428302568
effective search space used: 1428302568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.