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Search of human proteins with 45935391
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45935391 coiled-coil domain containing 69 [Homo sapiens]
(296 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45935391 coiled-coil domain containing 69 [Homo sapiens] 582 e-166
gi|57768564 hypothetical protein LOC23281 isoform b [Homo sapiens] 137 1e-32
gi|140161498 hypothetical protein LOC23281 isoform a [Homo sapiens] 137 1e-32
gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo sap... 112 4e-25
gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sap... 112 4e-25
gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sap... 112 4e-25
gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo sap... 112 4e-25
gi|148746195 trichohyalin [Homo sapiens] 64 1e-10
gi|190194355 p90 autoantigen [Homo sapiens] 62 6e-10
gi|221139761 zinc finger protein 853 [Homo sapiens] 59 5e-09
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 57 3e-08
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 55 6e-08
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 55 7e-08
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 55 7e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 54 1e-07
gi|219803769 trichoplein [Homo sapiens] 54 1e-07
gi|14150056 trichoplein [Homo sapiens] 54 1e-07
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 54 2e-07
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 54 2e-07
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 54 2e-07
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 54 2e-07
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 54 2e-07
gi|58530840 desmoplakin isoform I [Homo sapiens] 53 4e-07
gi|34878777 ring finger protein 20 [Homo sapiens] 53 4e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 53 4e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 53 4e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 53 4e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 53 4e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 53 4e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 53 4e-07
>gi|45935391 coiled-coil domain containing 69 [Homo sapiens]
Length = 296
Score = 582 bits (1499), Expect = e-166
Identities = 296/296 (100%), Positives = 296/296 (100%)
Query: 1 MGCRHSRLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDI 60
MGCRHSRLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDI
Sbjct: 1 MGCRHSRLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDI 60
Query: 61 TRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALT 120
TRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALT
Sbjct: 61 TRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALT 120
Query: 121 HSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELES 180
HSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELES
Sbjct: 121 HSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELES 180
Query: 181 LHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQL 240
LHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQL
Sbjct: 181 LHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQL 240
Query: 241 SEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTPTEVSFLAT 296
SEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTPTEVSFLAT
Sbjct: 241 SEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTPTEVSFLAT 296
>gi|57768564 hypothetical protein LOC23281 isoform b [Homo sapiens]
Length = 348
Score = 137 bits (345), Expect = 1e-32
Identities = 84/282 (29%), Positives = 158/282 (56%), Gaps = 2/282 (0%)
Query: 7 RLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQ 66
+L K ++R E E ++ + EL L + + + E H + I Q
Sbjct: 49 KLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQ 108
Query: 67 HEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREA 126
H+E+ + + LE+ + +L+ ++ +Q L +++E EK+ L +F +
Sbjct: 109 HQEQVEDLTASHDAAL-LEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKL 167
Query: 127 SSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIE 186
+ Q+ +D LT Q ++ + + +R EE+ L +N ++ ++ +P Q E++++SL V+E
Sbjct: 168 RLSLQDQVDTLTFQSQSLRDRARRFEEA-LRKNTEEQLEIALAPYQHLEEDMKSLKQVLE 226
Query: 187 MKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLL 246
MKN++IHE +++++ +E + EKN+ILEEKI LQQ+NEDL R V++RQLSE+
Sbjct: 227 MKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENAN 286
Query: 247 TREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTP 288
+E +EKE Q +++L + EELL+++ + + L+P +P
Sbjct: 287 LQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSP 328
>gi|140161498 hypothetical protein LOC23281 isoform a [Homo sapiens]
Length = 1379
Score = 137 bits (345), Expect = 1e-32
Identities = 84/282 (29%), Positives = 158/282 (56%), Gaps = 2/282 (0%)
Query: 7 RLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQ 66
+L K ++R E E ++ + EL L + + + E H + I Q
Sbjct: 1080 KLQKEKEELERRFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQ 1139
Query: 67 HEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREA 126
H+E+ + + LE+ + +L+ ++ +Q L +++E EK+ L +F +
Sbjct: 1140 HQEQVEDLTASHDAAL-LEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKL 1198
Query: 127 SSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIE 186
+ Q+ +D LT Q ++ + + +R EE+ L +N ++ ++ +P Q E++++SL V+E
Sbjct: 1199 RLSLQDQVDTLTFQSQSLRDRARRFEEA-LRKNTEEQLEIALAPYQHLEEDMKSLKQVLE 1257
Query: 187 MKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLL 246
MKN++IHE +++++ +E + EKN+ILEEKI LQQ+NEDL R V++RQLSE+
Sbjct: 1258 MKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENAN 1317
Query: 247 TREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVTP 288
+E +EKE Q +++L + EELL+++ + + L+P +P
Sbjct: 1318 LQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPIKLSPTSP 1359
>gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo
sapiens]
Length = 436
Score = 112 bits (280), Expect = 4e-25
Identities = 68/229 (29%), Positives = 130/229 (56%), Gaps = 13/229 (5%)
Query: 54 ERHQKDITRILQQHEEEKKKWAQQVEKE----------RELELRDRLDEQQRVLEGKNEE 103
E + ++ ++ + EE +K+ Q++++ +LE+ E+ +L+ E
Sbjct: 175 EFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEA 234
Query: 104 ALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKH 163
+L ++ +E EK++L E + ++ I+ L S+ +A K+K E+ +R K +
Sbjct: 235 SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRARE-KAN 293
Query: 164 IQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQEN 223
+++ + EQELESL V+E+KNE++H+ D +L+ ME + + N L +K+ QQEN
Sbjct: 294 LKN--PQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 351
Query: 224 EDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRV 272
E+L R + +SRQLS + + +E+LEKE ++ ++L E EELL+++
Sbjct: 352 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 400
>gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sapiens]
Length = 1270
Score = 112 bits (280), Expect = 4e-25
Identities = 68/229 (29%), Positives = 130/229 (56%), Gaps = 13/229 (5%)
Query: 54 ERHQKDITRILQQHEEEKKKWAQQVEKE----------RELELRDRLDEQQRVLEGKNEE 103
E + ++ ++ + EE +K+ Q++++ +LE+ E+ +L+ E
Sbjct: 1009 EFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEA 1068
Query: 104 ALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKH 163
+L ++ +E EK++L E + ++ I+ L S+ +A K+K E+ +R K +
Sbjct: 1069 SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRARE-KAN 1127
Query: 164 IQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQEN 223
+++ + EQELESL V+E+KNE++H+ D +L+ ME + + N L +K+ QQEN
Sbjct: 1128 LKN--PQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 1185
Query: 224 EDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRV 272
E+L R + +SRQLS + + +E+LEKE ++ ++L E EELL+++
Sbjct: 1186 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 1234
>gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sapiens]
Length = 1216
Score = 112 bits (280), Expect = 4e-25
Identities = 68/229 (29%), Positives = 130/229 (56%), Gaps = 13/229 (5%)
Query: 54 ERHQKDITRILQQHEEEKKKWAQQVEKE----------RELELRDRLDEQQRVLEGKNEE 103
E + ++ ++ + EE +K+ Q++++ +LE+ E+ +L+ E
Sbjct: 955 EFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEA 1014
Query: 104 ALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKH 163
+L ++ +E EK++L E + ++ I+ L S+ +A K+K E+ +R K +
Sbjct: 1015 SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRARE-KAN 1073
Query: 164 IQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQEN 223
+++ + EQELESL V+E+KNE++H+ D +L+ ME + + N L +K+ QQEN
Sbjct: 1074 LKN--PQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 1131
Query: 224 EDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRV 272
E+L R + +SRQLS + + +E+LEKE ++ ++L E EELL+++
Sbjct: 1132 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 1180
>gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo
sapiens]
Length = 517
Score = 112 bits (280), Expect = 4e-25
Identities = 68/229 (29%), Positives = 130/229 (56%), Gaps = 13/229 (5%)
Query: 54 ERHQKDITRILQQHEEEKKKWAQQVEKE----------RELELRDRLDEQQRVLEGKNEE 103
E + ++ ++ + EE +K+ Q++++ +LE+ E+ +L+ E
Sbjct: 256 EFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEA 315
Query: 104 ALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKH 163
+L ++ +E EK++L E + ++ I+ L S+ +A K+K E+ +R K +
Sbjct: 316 SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRARE-KAN 374
Query: 164 IQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQEN 223
+++ + EQELESL V+E+KNE++H+ D +L+ ME + + N L +K+ QQEN
Sbjct: 375 LKN--PQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 432
Query: 224 EDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRV 272
E+L R + +SRQLS + + +E+LEKE ++ ++L E EELL+++
Sbjct: 433 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 481
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 64.3 bits (155), Expect = 1e-10
Identities = 73/272 (26%), Positives = 123/272 (45%), Gaps = 21/272 (7%)
Query: 15 KKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQ---HEEEK 71
+++RQE E +Q +L + Q E+ ER ++ R QQ +EE+
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 72 KKW---AQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASS 128
++ +Q E+ RE +LR +E++R + + E+ L+ + +++ R
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 406
Query: 129 TQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMK 188
++E R QL Q + EE R+ +KH Q+ EQE E +
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEE---ERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 189 NERIHELDRRLILM-----ETVKEKNLILEEKITTLQQENEDLHVR----SRNQVVLSRQ 239
ER HE +RR + E +E+ L LEE+ QQE + +R R + L RQ
Sbjct: 464 TER-HEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Query: 240 LSEDLLLTREALEKEVQLRRQLQQEKEELLYR 271
E+ L ++ L E QLRR+ ++ +E+LL R
Sbjct: 523 EEEERL--QQRLRSEQQLRREQEERREQLLKR 552
Score = 56.6 bits (135), Expect = 3e-08
Identities = 59/249 (23%), Positives = 113/249 (45%), Gaps = 35/249 (14%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQQVEKERELE---------LRDRLDEQQRVLEGKN 101
EE + Q+D R Q + +KW Q+E+ER+ L+++L ++Q++L+ +
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 102 EEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQA-----------KMKR 150
EE + R ++++ +RE QQE L + E + K+++
Sbjct: 911 EELQREEREKRRRQEQE--RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 151 VEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNL 210
EE +L +K + E+EL+ + ++ ER E RR ++K+
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL-LREER--EKRRRQEWERQYRKKDE 1025
Query: 211 ILEEKITTLQQENEDLHVRSRNQVVLSR---QLSEDLLL-------TREALEKEVQLRRQ 260
+ +E+ L++E E ++ R + Q E+ LL R+ LE++ + +
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085
Query: 261 LQQEKEELL 269
LQQE+E+LL
Sbjct: 1086 LQQEEEQLL 1094
Score = 52.8 bits (125), Expect = 4e-07
Identities = 62/251 (24%), Positives = 103/251 (41%), Gaps = 40/251 (15%)
Query: 46 QLCASEEAERHQKDITRILQQHEEEKKKWAQQVEKEREL-------------------EL 86
QL A E +R Q R L + EE++++ Q+ E+E+EL E
Sbjct: 797 QLRAEERQQREQ----RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852
Query: 87 RDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTH------SFREASSTQQETIDRLTSQ 140
D L E Q + + Q R E+E++ H + +E +Q+ + +
Sbjct: 853 EDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912
Query: 141 LEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLI 200
L+ + + +R +E R Y++ Q Q +E E + ER + D++L
Sbjct: 913 LQREEREKRRRQEQ--ERQYREEEQLQQEEEQLLREEREKRR---RQERERQYRKDKKL- 966
Query: 201 LMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRR- 259
KE+ L+ EE +QE E + QL + R E E Q R+
Sbjct: 967 ---QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 260 -QLQQEKEELL 269
+LQQE+E+LL
Sbjct: 1024 DELQQEEEQLL 1034
Score = 52.4 bits (124), Expect = 5e-07
Identities = 61/260 (23%), Positives = 114/260 (43%), Gaps = 24/260 (9%)
Query: 15 KKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDIT--------RILQQ 66
++ R PE EQ R E E + + QL E E+ ++ T ++LQ+
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Query: 67 HEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREA 126
EE+ + ++ K RE ELR + ++ ++ LE + Q + +E++ L RE
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQ-EQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE- 1405
Query: 127 SSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYK-KHIQDYGSPSQFWEQELESLHFVI 185
QL + + R EE LSR + + ++ + E+E + L
Sbjct: 1406 ------------QQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Query: 186 EMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLL 245
+++ ER + L++ +E+ L +E+ +E + L + R++ ++L
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQ-E 1512
Query: 246 LTREALEKEVQLRRQLQQEK 265
R+ LE+E QL RQ +Q K
Sbjct: 1513 PERKFLEEEQQLHRQQRQRK 1532
Score = 52.0 bits (123), Expect = 6e-07
Identities = 58/290 (20%), Positives = 114/290 (39%), Gaps = 47/290 (16%)
Query: 12 KPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEK 71
+P K++RQE E + E + QL E +R ++++ R ++ EE +
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEE---------QLLREEREKRRRQELERQYREEEEVQ 1147
Query: 72 KKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQ 131
++ Q + +E E R L+ Q R E +E Q+LR E+ ++ +RE Q+
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207
Query: 132 ETI------------------------------------DRLTSQLEAFQAKMKRVEESI 155
+ + QLE Q + ++ ++ +
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDL 1267
Query: 156 LSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEK 215
++ +D + W+Q HF E + ER + + + ++ +EK L+ EE+
Sbjct: 1268 QHLLGEQQERDREQERRRWQQR--DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREER 1325
Query: 216 ITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEK 265
+++ D R Q++ R+ R+ +E +LR Q Q K
Sbjct: 1326 EEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Score = 50.1 bits (118), Expect = 2e-06
Identities = 71/288 (24%), Positives = 121/288 (42%), Gaps = 50/288 (17%)
Query: 4 RHSRLSSCKPPKKK--RQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDIT 61
R S++ S +P K++ R+ E E+ R EL + A Q + E ++D T
Sbjct: 715 RQSKVYS-RPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ-----QEEEQRRDFT 768
Query: 62 RILQQHEEEKKKWAQQ---------VEKERELELRDRLDEQQRVLEGKNEEALQVLRASY 112
Q EEK + +Q ++ER+L +R +QR L + EE Q R
Sbjct: 769 --WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLP-EEEEKEQRRRQRR 825
Query: 113 EQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQ 172
E+EKE L E ++E +L + + Q +R R+ K
Sbjct: 826 EREKE-LQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK----------- 873
Query: 173 FWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRN 232
W +LE E + R H L + L E ++++ +L+E+ LQ+E + R
Sbjct: 874 -WRWQLE------EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ 926
Query: 233 QVVLSR----QLSEDLLL-------TREALEKEVQLRRQLQQEKEELL 269
+ Q E+ LL R+ E++ + ++LQQ++E+LL
Sbjct: 927 ERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL 974
Score = 48.9 bits (115), Expect = 5e-06
Identities = 63/283 (22%), Positives = 125/283 (44%), Gaps = 32/283 (11%)
Query: 7 RLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQ 66
+L SCK + + + P+ EQ R E EL + ++ R ++D R+ Q+
Sbjct: 192 QLQSCKGHETE-EFPDEEQLRRRELLELRRKGREE--------KQQQRRERQD--RVFQE 240
Query: 67 HEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEAL----QVLRASYEQEKEALTHS 122
EE++ + + V ++ E +L++ ++QR L+ + E+ Q LR ++E++
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 123 FREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQF---WEQELE 179
RE +++ +R Q E + + +R ++ + Q+ Q E+E
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360
Query: 180 SLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQ 239
E + ER + RR + +E+ L E+++ QQ + +R Q+ +Q
Sbjct: 361 EQQLRREQEEERREQQLRRE--QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418
Query: 240 LSEDLLLTREALE-----------KEVQLRRQLQQEKEELLYR 271
L + L RE E +E +L+R+ Q+E+ + L R
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKRE-QEERRDWLKR 460
Score = 48.9 bits (115), Expect = 5e-06
Identities = 57/228 (25%), Positives = 104/228 (45%), Gaps = 34/228 (14%)
Query: 46 QLCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEAL 105
QL +E ERH+ Q+HE+E+++ Q++++E+E E RD L ++ + E
Sbjct: 424 QLRREQEEERHE-------QKHEQERRE--QRLKREQE-ERRDWLKREEETERHEQERRK 473
Query: 106 QVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQ 165
Q L+ E+E+ E +Q+ +R QL Q + R E+ + + ++ +Q
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQ--ERREQQLRREQEE--RREQRLKRQEEEERLQ 529
Query: 166 D-YGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENE 224
S Q ++ E +++ + E+ E +RR E+++ Q+E
Sbjct: 530 QRLRSEQQLRREQEERREQLLKREEEKRLEQERR--------------EQRLKREQEERR 575
Query: 225 DLHVR---SRNQVVLSRQLSEDL--LLTREALEKEVQLRRQLQQEKEE 267
D ++ R Q L R+ E L L RE +E+ Q R+ Q+ K E
Sbjct: 576 DQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE 623
Score = 48.1 bits (113), Expect = 9e-06
Identities = 54/219 (24%), Positives = 100/219 (45%), Gaps = 22/219 (10%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQQVEKERELE-LRDRLDEQQRVLEGKNEEALQVLR 109
EE ER ++ R Q E++++ Q+++++ E E L+ RL +Q++ + E Q+L+
Sbjct: 492 EEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551
Query: 110 ASYEQEKEALTHSFREASSTQQETIDRLTS-QLEAFQAKMKRVEESILSRNYKKHIQDYG 168
E+ E R Q+E D+L + E Q ++KR +E L + K+ +
Sbjct: 552 REEEKRLEQERREQR-LKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 169 SPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHV 228
+ EQ L+ + E E ++L+ E +E+ ++++ QQE
Sbjct: 611 EQEERREQRLK--------REEPEEERRQQLLKSEEQEERR---QQQLRREQQE------ 653
Query: 229 RSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEE 267
R + L R+ E+ L R E E + R Q E+E+
Sbjct: 654 --RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Score = 45.8 bits (107), Expect = 4e-05
Identities = 47/210 (22%), Positives = 90/210 (42%), Gaps = 13/210 (6%)
Query: 65 QQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNE-EALQVLRASYEQEKEALTHSF 123
Q+ E E + +Q EK+ LE RDR + + + E + + RA EQ + H
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 124 REASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHF 183
E +Q + E + + K EE + ++ QD + E+E
Sbjct: 202 EEFPDEEQ------LRRRELLELRRKGREE---KQQQRRERQDRVFQEE-EEKEWRKRET 251
Query: 184 VIEMKNERIHELD--RRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLS 241
V+ + E++ E + R+ L E ++ + +++ +QE E R R + L R+
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311
Query: 242 EDLLLTREALEKEVQLRRQLQQEKEELLYR 271
E+ +E ++ + R Q ++ +E+ L R
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRR 341
Score = 45.8 bits (107), Expect = 4e-05
Identities = 61/264 (23%), Positives = 113/264 (42%), Gaps = 33/264 (12%)
Query: 15 KKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKW 74
K++ + E EQ R EP + + Q EE ++ ++ + R EE +K+
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERER----QCREEEELQQEEEQLLR-----EEREKRR 1132
Query: 75 AQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETI 134
Q++E++ E + +E+Q + E + Q L Y +E+E +E +E
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ----QEEEQLLREEQ 1188
Query: 135 DRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQF-WEQELESLHFVIEMK----- 188
++ + E + R EE + + K+ +D S W+ E E + V + K
Sbjct: 1189 EKRRQERE----RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 189 --NERIHEL-DRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLL 245
NE+ +L D +L ++ ++ +L E Q+ D R R E+
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGE------QQERDREQERRRWQQRDRHFPEEEQ 1298
Query: 246 LTREALEKEVQLRRQLQQEKEELL 269
L RE +KE + R + QE+++LL
Sbjct: 1299 LEREE-QKEAKRRDRKSQEEKQLL 1321
Score = 45.8 bits (107), Expect = 4e-05
Identities = 53/227 (23%), Positives = 100/227 (44%), Gaps = 33/227 (14%)
Query: 46 QLCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQ---QRVLEGKNE 102
QL E ++ ++D R ++ E+ +++ +Q +E + + RL+EQ ++ E K
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFM 1598
Query: 103 EALQVLR--ASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNY 160
E Q LR +Q ++ FRE QE R QL + K +EE
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQE---REEQQLHRQERDRKFLEEE------ 1649
Query: 161 KKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQ 220
Q QE E +++++R + L++ +E+ L +E+ +
Sbjct: 1650 ----------PQLRRQEREQ-----QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFR 1694
Query: 221 QENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEE 267
+E + L + R + + L E+ L R+ LE++ + QL+QE E+
Sbjct: 1695 EEEQQLRRQERER----KFLQEEQQLRRQELERKFREEEQLRQETEQ 1737
Score = 45.4 bits (106), Expect = 6e-05
Identities = 63/229 (27%), Positives = 105/229 (45%), Gaps = 27/229 (11%)
Query: 52 EAERHQKDITRILQQHEEEKKK----WAQQVEKERELELRDRLDEQQRVLEGKNEEALQV 107
E E Q++ ++L+ EE +K+ W +Q K+ EL+ +E+Q + E + + LQ
Sbjct: 992 EEEELQQEEEQLLR--EEREKRRRQEWERQYRKKDELQ----QEEEQLLREEREKRRLQE 1045
Query: 108 LRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAK---MKRVEESILSRNYKKHI 164
Y +E+E L + ++ET R +LE K +++ EE +L +K
Sbjct: 1046 RERQYREEEE-LQQEEEQLLGEERET--RRRQELERQYRKEEELQQEEEQLLREEPEKRR 1102
Query: 165 QDYGSPSQFWEQELESLHFVI---EMKNERIHELDRRLILMETV--KEKNLILEEKITTL 219
+ E+EL+ + E + R EL+R+ E V +E+ L+ EE
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162
Query: 220 QQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
+QE E R + +Q E LL RE EK Q R + +E+EEL
Sbjct: 1163 RQELE----RQYREEEELQQEEEQLL--REEQEKRRQERERQYREEEEL 1205
Score = 43.1 bits (100), Expect = 3e-04
Identities = 64/268 (23%), Positives = 113/268 (42%), Gaps = 29/268 (10%)
Query: 4 RHSRLSSCKPPKKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRI 63
RH R + ++ QE E +Q R E QL E + ++ ++
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQ-----QLRRQERERKFLQEEQQL 1716
Query: 64 LQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSF 123
+Q E K + +Q+ +E E E R + +++LE EE L+ R + ++ F
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYRKILE---EEQLRPEREEQQLRRQERDRKF 1773
Query: 124 REASSTQQETIDRLTSQLEAFQAKMK-RVEESILSRNYKKHIQDYGSPSQF-WEQELESL 181
RE +QE R QL + ++ K R EE + ++ ++ ++ WE+E L
Sbjct: 1774 REEEQLRQE---REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQL 1830
Query: 182 HFVIEMKNERIHELDRRLILME--TVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQ 239
E + E DR+ E +EK+ E++ L QE E + R R+
Sbjct: 1831 E---EQEQRLRQERDRQYRAEEQFATQEKSRREEQE---LWQEEEQKRRQER-----ERK 1879
Query: 240 LSEDLLLTREALEKEVQLRRQLQQEKEE 267
L E+ + + +KE Q RQ+ + K +
Sbjct: 1880 LREEHIRRQ---QKEEQRHRQVGEIKSQ 1904
Score = 38.5 bits (88), Expect = 0.007
Identities = 58/245 (23%), Positives = 105/245 (42%), Gaps = 29/245 (11%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQQVEKERELELR------DRLDEQQR-----VLEG 99
+ +R Q++ L + EEE+++ + E+E LE R +RL++++R E
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Query: 100 KNEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRV------EE 153
EE Q L S EQE+ RE +++ + R + E + ++KR E+
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR-EEEEERLEQRLKREHEEERREQ 683
Query: 154 SILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMK---NERIHELDRRLILMETV---KE 207
+ ++ + S W+ +LES + K R E RR E +E
Sbjct: 684 ELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRE 743
Query: 208 KNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSE---DLLLTREAL--EKEVQLRRQLQ 262
L +E+ +Q+ E+ R + + SE L R L ++E QLR + +
Sbjct: 744 SELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEER 803
Query: 263 QEKEE 267
Q++E+
Sbjct: 804 QQREQ 808
Score = 38.5 bits (88), Expect = 0.007
Identities = 48/218 (22%), Positives = 95/218 (43%), Gaps = 18/218 (8%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRA 110
++ +R ++ + L + E ++K ++ + R+ R L+E+Q++ + ++ + + +
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469
Query: 111 SYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEE---SILSRNYKKHIQDY 167
E+E++ L R+ ++E R + F+ + R +E L + H Q
Sbjct: 1470 LQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQR 1529
Query: 168 GSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLH 227
EQ+L E +R + DR+ +E+ L E + L ++ D
Sbjct: 1530 QRKFLQEEQQLRRQ----ERGQQRRQDRDRKF-----REEEQLRQEREEQQLSRQERDRK 1580
Query: 228 VRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEK 265
R Q V RQ E R+ +E E QLRRQ Q++
Sbjct: 1581 FRLEEQKV-RRQEQE-----RKFMEDEQQLRRQEGQQQ 1612
Score = 35.0 bits (79), Expect = 0.079
Identities = 49/227 (21%), Positives = 98/227 (43%), Gaps = 23/227 (10%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRA 110
E A R K + + + + + +Q +++ + +L+ L EQQ + Q
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDR 1291
Query: 111 SYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMK--------RVEESILSRNYKK 162
+ +E++ +EA +++ + E + K + R EE +L ++
Sbjct: 1292 HFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351
Query: 163 HIQDYGSPSQFWEQEL----ESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITT 218
++ +F E+EL + F+ E + R E +R+ + +E+ L +E+
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFL----KEEQQLRCQEREQQ 1407
Query: 219 LQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEK 265
L+Q+ D R Q LSRQ + R+ E+E Q+RRQ ++ K
Sbjct: 1408 LRQD-RDRKFREEEQ-QLSRQERD-----RKFREEEQQVRRQERERK 1447
>gi|190194355 p90 autoantigen [Homo sapiens]
Length = 905
Score = 62.0 bits (149), Expect = 6e-10
Identities = 69/249 (27%), Positives = 113/249 (45%), Gaps = 31/249 (12%)
Query: 30 EPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKW-----AQQVEKEREL 84
E L D I C +AE + + +L++ E + ++ AQQVE ER
Sbjct: 645 ETKALALAQADRLIAQHRCQRTQAETEARTLASMLREVERKNEELSVLLKAQQVESERAQ 704
Query: 85 ELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAF 144
+ L + R LE EE ++L SY E S + + Q T D L Q+E
Sbjct: 705 SDIEHLFQHNRKLESVAEEH-EILTKSY-MELLQRNESTEKKNKDLQITCDSLNKQIET- 761
Query: 145 QAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMET 204
+K++ ES+ +N K S +Q E+E E + E ++L R +
Sbjct: 762 ---VKKLNESLKEQNEK-------SIAQLIEKE--------EQRKEVQNQLVDREHKLAN 803
Query: 205 VKEKNLILEEKITTLQQENEDLHVR---SRNQVVLSRQLSEDLLLTREALE-KEVQLRRQ 260
+ +K + EEKI TLQ+E ED R ++ + Q+ ++L + +LE ++ QL +
Sbjct: 804 LHQKTKVQEEKIKTLQKEREDKEETIDILRKELSRTEQIRKELSIKASSLEVQKAQLEGR 863
Query: 261 LQQEKEELL 269
L +EKE L+
Sbjct: 864 L-EEKESLV 871
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 58.9 bits (141), Expect = 5e-09
Identities = 53/270 (19%), Positives = 123/270 (45%), Gaps = 15/270 (5%)
Query: 2 GCRHSRLSSCKPPKKKRQEPEPEQPPRPEPH---ELGPLNGDTAITVQLCASEEAERHQK 58
G R +L + + +Q+P+ EQ +P+PH + P QL + H +
Sbjct: 85 GQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQ 144
Query: 59 DITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEA 118
++ LQ ++++ QQV++++ RL +QQ L+ + + QVL+ + +++
Sbjct: 145 ELKPELQLMHQQQQLQPQQVQEQQ------RLQQQQEQLQTQQAQEQQVLQQQEQLQQQV 198
Query: 119 LTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQEL 178
+ Q + L Q + Q + ++ +E + + +Q G Q Q+
Sbjct: 199 QEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQ- 257
Query: 179 ESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSR 238
+ ++ ++ +L ++L+L + ++ L +++ LQQ+ E L + L
Sbjct: 258 QQAQLQQQLLEQQQAQLQQQLLLQQ---QEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEP 314
Query: 239 QLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
+ E++ L E + ++ ++L+Q+++EL
Sbjct: 315 EEEEEVEL--ELMPVDLGSEQELEQQRQEL 342
Score = 50.4 bits (119), Expect = 2e-06
Identities = 52/263 (19%), Positives = 121/263 (46%), Gaps = 28/263 (10%)
Query: 24 EQPPRPEPHELGPLNGDTAITVQLCASEEAE-----RHQKDITRILQQHEEEKKKWAQQV 78
E EP E A++ + ASE AE + + + ++ QQ E +++ +Q+
Sbjct: 50 ESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQL 109
Query: 79 EKER---ELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETID 135
++ + EL+ + + D QQ++ + + E+ V + E + L H ++ Q +
Sbjct: 110 QQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQ-LMHQQQQLQPQQVQEQQ 168
Query: 136 RLTSQLEAFQA----------KMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVI 185
RL Q E Q + +++++ + + + Q+ Q +Q+ +
Sbjct: 169 RLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQF 228
Query: 186 EMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLL 245
+ + E++ + + L+L + + + +L+++ LQQ+ + + Q QL + LL
Sbjct: 229 QQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQ-----LLEQQQA----QLQQQLL 279
Query: 246 LTREALEKEVQLRRQLQQEKEEL 268
L ++ ++ Q ++ LQQ++E+L
Sbjct: 280 LQQQEQLQQQQQQQLLQQQQEQL 302
Score = 35.0 bits (79), Expect = 0.079
Identities = 39/197 (19%), Positives = 89/197 (45%), Gaps = 6/197 (3%)
Query: 17 KRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQ 76
++Q+ + +Q + +L L + QL ++A+ Q+ + + QQ + +++ Q
Sbjct: 224 QQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQ--QQAQLQQQLLLQ 281
Query: 77 QVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETIDR 136
Q E+ ++ + + L +QQ L+ ++ LQ E+E+E ++QE +++
Sbjct: 282 QQEQLQQQQQQQLLQQQQEQLQ---QQQLQPPPLEPEEEEEVELELMPVDLGSEQE-LEQ 337
Query: 137 LTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELD 196
+LE Q ++ E+ L ++ +Q + +Q+LE +E+ +
Sbjct: 338 QRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQ 397
Query: 197 RRLILMETVKEKNLILE 213
+ + L T + L LE
Sbjct: 398 QEVQLELTPVQPELQLE 414
Score = 32.7 bits (73), Expect = 0.39
Identities = 30/124 (24%), Positives = 62/124 (50%), Gaps = 21/124 (16%)
Query: 15 KKKRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKW 74
++++ +P P +P E EL + V L + +E E+ ++++ R Q E E+
Sbjct: 303 QQQQLQPPPLEPEEEEEVEL------ELMPVDLGSEQELEQQRQELER---QQELER--- 350
Query: 75 AQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETI 134
QQ +++ +L+L++ L + ++ LE + ++ EQ++ L + E + QQE
Sbjct: 351 -QQEQRQLQLKLQEELQQLEQQLEQQQQQ--------LEQQEVQLELTPVELGAQQQEVQ 401
Query: 135 DRLT 138
LT
Sbjct: 402 LELT 405
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 56.6 bits (135), Expect = 3e-08
Identities = 74/314 (23%), Positives = 133/314 (42%), Gaps = 36/314 (11%)
Query: 15 KKKRQEPEPEQPPRPEPHELGPLNG----------DTAITVQLCASEEAERHQKD--ITR 62
K KR E ++ HE G L G +I A EA+ Q + +
Sbjct: 1099 KIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQA 1158
Query: 63 ILQQHEEEKKKW-----AQQVEKERELELRDRLDEQ---QRVLEGKNEE-----ALQVLR 109
+LQ+ EEE ++ A Q E+E E + L EQ +V G N +L++
Sbjct: 1159 VLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSE 1218
Query: 110 ASYE-QEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYG 168
E Q KE L + + Q + + ++ FQA++ + + +K + +
Sbjct: 1219 VKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQL--QLLQKQLDEQL 1276
Query: 169 SPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNL-----ILEEKITTLQQEN 223
S QE+E+L + ++ K I L ++L L E K L +L+ + L+
Sbjct: 1277 SKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQ 1336
Query: 224 EDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVLG--ANASPAF 281
EDL + +++ +L ++SE + L++ QL+ L++ + G ++++PA
Sbjct: 1337 EDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPAT 1396
Query: 282 PL-APVTPTEVSFL 294
P+ P P S L
Sbjct: 1397 PIKIPDCPVPASLL 1410
Score = 44.3 bits (103), Expect = 1e-04
Identities = 61/253 (24%), Positives = 115/253 (45%), Gaps = 44/253 (17%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERE-LELRDRLDEQQRVLEGKNEEALQV 107
A + A+ ++++ R ++ EE ++ ++ +EK RE L ++ E + ++ +Q
Sbjct: 781 ALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQK 840
Query: 108 LRASYEQEKEALTHSFREASSTQQ------ETIDRLTSQLEAFQAKM------KRVEESI 155
++ + Q+K + R+A+S Q T RL S+L+ + ++ KR E+
Sbjct: 841 IKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAE 900
Query: 156 LSRNYKK-------------HIQDYGSPSQFWEQELESLHF-------------VIEMKN 189
LSR +++ H+Q E L+SL F ++ +
Sbjct: 901 LSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQI 960
Query: 190 ERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQV-VLSRQLSEDLLLTR 248
E + + R+ I + K+K L +T+ Q+E + H N V +LSR+L E L +
Sbjct: 961 EELQQEARKAITEQ--KQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQE-ALAAK 1017
Query: 249 EALEKEV-QLRRQ 260
EA + E+ QLR Q
Sbjct: 1018 EAADAELGQLRAQ 1030
Score = 38.1 bits (87), Expect = 0.009
Identities = 57/242 (23%), Positives = 103/242 (42%), Gaps = 47/242 (19%)
Query: 58 KDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKN--EEALQVLRASYEQE 115
+ +T + +EK + A Q++ E ++ D+ ++ E K EE LQ +E E
Sbjct: 622 QQLTETQHRSMKEKGRIAAQLQGI-EADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGE 680
Query: 116 KEALTHSFREASSTQQE------TIDRLTSQLEAFQAK----MKRV---EESILSRNYKK 162
+E L A+S +Q+ T+ + QLEA Q + MK++ +E++ SR
Sbjct: 681 RERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSR---- 736
Query: 163 HIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMET----VKEKNLILEEKITT 218
EQ L++L + R+ EL E ++ + +ILE +
Sbjct: 737 ------------EQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQA 784
Query: 219 LQQENEDLHVRSRNQVVLSRQLSEDLLLTREAL-----------EKEVQLRRQLQQEKEE 267
+ E+L +R + + SE L RE L ++ L++Q+Q+ KE+
Sbjct: 785 AKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQ 844
Query: 268 LL 269
L
Sbjct: 845 FL 846
Score = 36.2 bits (82), Expect = 0.035
Identities = 45/180 (25%), Positives = 82/180 (45%), Gaps = 21/180 (11%)
Query: 93 QQRVLEGKNEEALQVLRA--SYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKR 150
Q R G ++ +L + + E E +A++HS QE I + +LE + K+
Sbjct: 1026 QLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLE 1085
Query: 151 VEESIL-SRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKN 209
+E+ + SR ++K I+ E+ + L +E + ++ L + ++E N
Sbjct: 1086 LEDELQESRGFRKKIKRL-------EESNKKLALELEHEKGKLTGLGQS---NAALREHN 1135
Query: 210 LILEEKITTLQQENEDL-HVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
ILE T L + DL + + Q VL R+ ED R+ L+ L++EKE++
Sbjct: 1136 SILE---TALAKREADLVQLNLQVQAVLQRKEEED----RQMKHLVQALQASLEKEKEKV 1188
Score = 33.5 bits (75), Expect = 0.23
Identities = 47/202 (23%), Positives = 82/202 (40%), Gaps = 23/202 (11%)
Query: 72 KKWAQQVEKERELELRDRLD-EQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQ 130
++W QQ + E R RL E + G+ +A L + E +L+ E
Sbjct: 575 RQWYQQ-QLALAQEARVRLQGEMAHIQVGQMTQA--GLLEHLKLENVSLSQQLTETQHRS 631
Query: 131 QETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNE 190
+ R+ +QL+ +A M E + + K + E++L+ E + E
Sbjct: 632 MKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMV---------EEDLQRRLEEFEGERE 682
Query: 191 RIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREA 250
R+ + +E LE+ TL Q ++ L + + L +QL+ LT+EA
Sbjct: 683 RLQRMADSAASLEQQ------LEQVKLTLLQRDQQLEALQQEHLDLMKQLT----LTQEA 732
Query: 251 LEKEVQLRRQLQQEKEELLYRV 272
L+ Q LQ +EL R+
Sbjct: 733 LQSREQSLDALQTHYDELQARL 754
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 55.5 bits (132), Expect = 6e-08
Identities = 68/256 (26%), Positives = 116/256 (45%), Gaps = 26/256 (10%)
Query: 23 PEQPPRPEPHELGPLNGDTAITVQLCASEEA--ERHQKDITRILQQHEEEKKKWAQQVEK 80
P+ PP +P L + V +A ER+Q D++R +Q +E + +E+
Sbjct: 89 PQPPPSQDPELLSVIRQKEKDLVLAARLGKALLERNQ-DMSRQYEQMHKELTDKLEHLEQ 147
Query: 81 ERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQ 140
E+ ELR R + ++ EG+ E ++ ++ + H REA + + L+ Q
Sbjct: 148 EKH-ELRRRFENREGEWEGRVSELESDVKQLQDELERQQIH-LREADREKSRAVQELSEQ 205
Query: 141 LEAFQAKMKRVEESILSRNYKKHI--QDYGSPSQFWEQE---LESLHFVIEMKNERIHEL 195
+ ++ R E + + H +D+ + Q LESL I+M ++R EL
Sbjct: 206 NQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKREL 265
Query: 196 DRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQ-LSEDLLLTREALE-K 253
+ RL E+N +L+ + LQ ++L RQ +DL L + LE +
Sbjct: 266 EHRL---SATLEENDLLQGTVEELQD----------RVLILERQGHDKDLQLHQSQLELQ 312
Query: 254 EVQLR-RQLQQEKEEL 268
EV+L RQLQ + EEL
Sbjct: 313 EVRLSCRQLQVKVEEL 328
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 55.1 bits (131), Expect = 7e-08
Identities = 62/233 (26%), Positives = 112/233 (48%), Gaps = 27/233 (11%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRA 110
E+ + Q+ + ++ + +E K++ Q+ E++R+LEL +L E+QR LE + EE +
Sbjct: 374 EQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQL-EKQRELERQREEERRKEIE 432
Query: 111 SYEQEKEAL--THSFREASSTQQETIDRLTSQLE---AFQAKMKRVEESILSRNYKKH-- 163
E K L + +QE +++ + E +AK K +E + + N KKH
Sbjct: 433 RREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQL 492
Query: 164 ---IQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRL-----ILMETVKEKNLILEEK 215
+QD QE+ES + E++ I L ++L +L + EK IL ++
Sbjct: 493 EGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQ-ILNDQ 551
Query: 216 ITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREAL-----EKEVQLRRQLQQ 263
+ +QQ + LH R+ +V ++ E L R+ L E E + R +LQ+
Sbjct: 552 LKQVQQNS--LH---RDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQE 599
Score = 42.7 bits (99), Expect = 4e-04
Identities = 47/226 (20%), Positives = 102/226 (45%), Gaps = 21/226 (9%)
Query: 65 QQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTH--- 121
Q+ E E ++++ L+ +L E Q++L G+ Q+L +Q ++ H
Sbjct: 506 QRQEIESTNKSRELRIAEITHLQQQLQESQQML-GRLIPEKQILNDQLKQVQQNSLHRDS 564
Query: 122 --SFREASSTQQETIDRLTSQLEAFQAKMK-RVEESILSRNYKKHIQDYGSPSQFWEQEL 178
+ + A ++ L QL+ + + + +++E + N K +++ + Q +Q+
Sbjct: 565 LVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQK- 623
Query: 179 ESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDL--HVRSRNQVVL 236
M+ ER+ + ++ ++E K+K EE Q+ ++ HV+ ++
Sbjct: 624 -------SMEAERLKQKEQERKIIELEKQK----EEAQRRAQERDKQWLEHVQQEDEHQR 672
Query: 237 SRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFP 282
R+L E+ L RE K+ + +QE ++ L R+ + PA P
Sbjct: 673 PRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKP 718
Score = 29.6 bits (65), Expect = 3.3
Identities = 18/71 (25%), Positives = 39/71 (54%), Gaps = 13/71 (18%)
Query: 197 RRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQ 256
RR L+E +++ +E++ L++ ++ R R + RQL LEK+++
Sbjct: 368 RRQALLEQQRKE----QERLAQLERAEQERKERERQEQERKRQLE---------LEKQLE 414
Query: 257 LRRQLQQEKEE 267
+R+L++++EE
Sbjct: 415 KQRELERQREE 425
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 55.1 bits (131), Expect = 7e-08
Identities = 62/233 (26%), Positives = 112/233 (48%), Gaps = 27/233 (11%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRA 110
E+ + Q+ + ++ + +E K++ Q+ E++R+LEL +L E+QR LE + EE +
Sbjct: 374 EQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQL-EKQRELERQREEERRKEIE 432
Query: 111 SYEQEKEAL--THSFREASSTQQETIDRLTSQLE---AFQAKMKRVEESILSRNYKKH-- 163
E K L + +QE +++ + E +AK K +E + + N KKH
Sbjct: 433 RREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQL 492
Query: 164 ---IQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRL-----ILMETVKEKNLILEEK 215
+QD QE+ES + E++ I L ++L +L + EK IL ++
Sbjct: 493 EGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQ-ILNDQ 551
Query: 216 ITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREAL-----EKEVQLRRQLQQ 263
+ +QQ + LH R+ +V ++ E L R+ L E E + R +LQ+
Sbjct: 552 LKQVQQNS--LH---RDSLVTLKRALEAKELARQHLRDQLDEVEKETRSKLQE 599
Score = 42.7 bits (99), Expect = 4e-04
Identities = 47/226 (20%), Positives = 102/226 (45%), Gaps = 21/226 (9%)
Query: 65 QQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTH--- 121
Q+ E E ++++ L+ +L E Q++L G+ Q+L +Q ++ H
Sbjct: 506 QRQEIESTNKSRELRIAEITHLQQQLQESQQML-GRLIPEKQILNDQLKQVQQNSLHRDS 564
Query: 122 --SFREASSTQQETIDRLTSQLEAFQAKMK-RVEESILSRNYKKHIQDYGSPSQFWEQEL 178
+ + A ++ L QL+ + + + +++E + N K +++ + Q +Q+
Sbjct: 565 LVTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQK- 623
Query: 179 ESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDL--HVRSRNQVVL 236
M+ ER+ + ++ ++E K+K EE Q+ ++ HV+ ++
Sbjct: 624 -------SMEAERLKQKEQERKIIELEKQK----EEAQRRAQERDKQWLEHVQQEDEHQR 672
Query: 237 SRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFP 282
R+L E+ L RE K+ + +QE ++ L R+ + PA P
Sbjct: 673 PRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKP 718
Score = 29.6 bits (65), Expect = 3.3
Identities = 18/71 (25%), Positives = 39/71 (54%), Gaps = 13/71 (18%)
Query: 197 RRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQ 256
RR L+E +++ +E++ L++ ++ R R + RQL LEK+++
Sbjct: 368 RRQALLEQQRKE----QERLAQLERAEQERKERERQEQERKRQLE---------LEKQLE 414
Query: 257 LRRQLQQEKEE 267
+R+L++++EE
Sbjct: 415 KQRELERQREE 425
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 54.3 bits (129), Expect = 1e-07
Identities = 46/223 (20%), Positives = 105/223 (47%), Gaps = 12/223 (5%)
Query: 46 QLCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEAL 105
Q+ EE R Q++ + + EE+ +K +QV+K+ E ++R + ++ + E E+
Sbjct: 221 QMGEQEEQMRKQEEQ---MGEQEEQVQKQEEQVQKQEE-QMRKQEEQMREQEEQMREQEE 276
Query: 106 QVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQ 165
Q+L+ + E+E T E Q+E + Q+ + +M+ EE + K+ Q
Sbjct: 277 QMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQM----GKQEEQ 332
Query: 166 DYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENED 225
+ Q WEQ+ E + E E+ ++ ++ E V+++ + ++ ++++ E
Sbjct: 333 MWEQKEQMWEQK-EQMWKQEEQMGEQEEQMQKQ---EEQVRKQEEQMRKQEEQMRKQEEQ 388
Query: 226 LHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
+ + Q+ E RE E+ + + Q+++++E +
Sbjct: 389 MRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHM 431
Score = 31.2 bits (69), Expect = 1.1
Identities = 41/207 (19%), Positives = 91/207 (43%), Gaps = 11/207 (5%)
Query: 65 QQHEEEKKKWAQQVE-KERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSF 123
Q E+E + Q+ + +E+E ++R++ + Q R EG+ E +R Q +E
Sbjct: 102 QVREQEGQVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVRE------ 154
Query: 124 REASSTQQE-TIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD--YGSPSQFWEQELES 180
+E +QE + Q+ + +++ E + + + Q+ G + ++ E
Sbjct: 155 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQ 214
Query: 181 LHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQL 240
+ E E+ ++ ++ M +E+ EE++ +++ + R Q R+
Sbjct: 215 MQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQ 274
Query: 241 SEDLLLTREALEKEVQLRRQLQQEKEE 267
E +L +E E+E Q Q +Q +E+
Sbjct: 275 EEQMLKQKEQTEQEEQTGEQEEQMREQ 301
Score = 29.6 bits (65), Expect = 3.3
Identities = 20/68 (29%), Positives = 36/68 (52%), Gaps = 7/68 (10%)
Query: 200 ILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRR 259
I E +KEKN L+E++ ++ E ++ + + L R+L D + L +E Q+R
Sbjct: 4 ITNEELKEKNAELQEELQLVETEKSEIQLHIKE---LKRKLETDKI----PLPQEGQVRE 56
Query: 260 QLQQEKEE 267
Q Q +E+
Sbjct: 57 QEGQVREQ 64
>gi|219803769 trichoplein [Homo sapiens]
Length = 498
Score = 54.3 bits (129), Expect = 1e-07
Identities = 49/219 (22%), Positives = 105/219 (47%), Gaps = 23/219 (10%)
Query: 52 EAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRAS 111
E + HQK + + +EEKK+ E+E + + E EAL+ ++A
Sbjct: 154 ELDLHQKHVVNSWEMQKEEKKQQEATAEQENK--------RYENEYERARREALERMKA- 204
Query: 112 YEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYK-KHIQDYGSP 170
E+E+ L +A + Q+ + ++EA K+K+ +E++L + ++ + +++
Sbjct: 205 -EEERRQLEDKL-QAEALLQQMEELKLKEVEA--TKLKKEQENLLKQRWELERLEEERKQ 260
Query: 171 SQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRS 230
+ + Q+ E F+ N +L RR ++ E + + + + + E++ LH+
Sbjct: 261 MEAFRQKAELGRFLRHQYNA---QLSRRTQQIQEELEADRRILQALLEKEDESQRLHLAR 317
Query: 231 RNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELL 269
R QV+ D+ ++A+E+++QL R + E + LL
Sbjct: 318 REQVM------ADVAWMKQAIEEQLQLERAREAELQMLL 350
Score = 28.1 bits (61), Expect = 9.7
Identities = 39/185 (21%), Positives = 75/185 (40%), Gaps = 16/185 (8%)
Query: 93 QQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQA----KM 148
QQR+ + + Q R + E+ + + S++Q TS + A KM
Sbjct: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
Query: 149 KRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEK 208
K + L +K Q +ELE L + ++ RI E +L + +++
Sbjct: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE-EQR 131
Query: 209 NLILEEKI--------TTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQ 260
LI E+ + L++ DLH + VV S ++ ++ +EA ++ R +
Sbjct: 132 KLIAEQLLYEHWKKNNPKLREMELDLH---QKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Query: 261 LQQEK 265
+ E+
Sbjct: 189 NEYER 193
Score = 28.1 bits (61), Expect = 9.7
Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 12/72 (16%)
Query: 206 KEKNLILE---EKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQ 262
+EK LE EK+ L QE +DL R ++ LS L E R E+ +L+ +
Sbjct: 74 EEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQE-----RRIREQHGKLKSAKE 128
Query: 263 QEK----EELLY 270
+++ E+LLY
Sbjct: 129 EQRKLIAEQLLY 140
>gi|14150056 trichoplein [Homo sapiens]
Length = 498
Score = 54.3 bits (129), Expect = 1e-07
Identities = 49/219 (22%), Positives = 105/219 (47%), Gaps = 23/219 (10%)
Query: 52 EAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRAS 111
E + HQK + + +EEKK+ E+E + + E EAL+ ++A
Sbjct: 154 ELDLHQKHVVNSWEMQKEEKKQQEATAEQENK--------RYENEYERARREALERMKA- 204
Query: 112 YEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYK-KHIQDYGSP 170
E+E+ L +A + Q+ + ++EA K+K+ +E++L + ++ + +++
Sbjct: 205 -EEERRQLEDKL-QAEALLQQMEELKLKEVEA--TKLKKEQENLLKQRWELERLEEERKQ 260
Query: 171 SQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRS 230
+ + Q+ E F+ N +L RR ++ E + + + + + E++ LH+
Sbjct: 261 MEAFRQKAELGRFLRHQYNA---QLSRRTQQIQEELEADRRILQALLEKEDESQRLHLAR 317
Query: 231 RNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELL 269
R QV+ D+ ++A+E+++QL R + E + LL
Sbjct: 318 REQVM------ADVAWMKQAIEEQLQLERAREAELQMLL 350
Score = 28.1 bits (61), Expect = 9.7
Identities = 39/185 (21%), Positives = 75/185 (40%), Gaps = 16/185 (8%)
Query: 93 QQRVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQA----KM 148
QQR+ + + Q R + E+ + + S++Q TS + A KM
Sbjct: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
Query: 149 KRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEK 208
K + L +K Q +ELE L + ++ RI E +L + +++
Sbjct: 73 KEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKE-EQR 131
Query: 209 NLILEEKI--------TTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQ 260
LI E+ + L++ DLH + VV S ++ ++ +EA ++ R +
Sbjct: 132 KLIAEQLLYEHWKKNNPKLREMELDLH---QKHVVNSWEMQKEEKKQQEATAEQENKRYE 188
Query: 261 LQQEK 265
+ E+
Sbjct: 189 NEYER 193
Score = 28.1 bits (61), Expect = 9.7
Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 12/72 (16%)
Query: 206 KEKNLILE---EKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQ 262
+EK LE EK+ L QE +DL R ++ LS L E R E+ +L+ +
Sbjct: 74 EEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQE-----RRIREQHGKLKSAKE 128
Query: 263 QEK----EELLY 270
+++ E+LLY
Sbjct: 129 EQRKLIAEQLLY 140
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 53.9 bits (128), Expect = 2e-07
Identities = 54/234 (23%), Positives = 112/234 (47%), Gaps = 39/234 (16%)
Query: 59 DITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRAS-----YE 113
++ R++ + +++K + +++ K RE + L +QQR +E + +LQ +RA Y
Sbjct: 1142 ELERMVAELKKQKSRVEEELPKVREAA-ENELRKQQRNVE---DISLQKIRAESEAKQYR 1197
Query: 114 QEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQF 173
+E E + +EA+ + E + +LT + EA K VEE++L N++ +++ + F
Sbjct: 1198 RELETIVRE-KEAAERELERVRQLTIEAEA---KRAAVEENLL--NFRNQLEE----NTF 1247
Query: 174 WEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQ 233
+ LE H + L L + ++KN ++EE E E L
Sbjct: 1248 TRRTLED------------HLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK------ 1289
Query: 234 VVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVLGANASPAFPLAPVT 287
L +Q+ +DL ++ EK+++ +++++ E + + A P+ P+T
Sbjct: 1290 --LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPIT 1341
Score = 42.7 bits (99), Expect = 4e-04
Identities = 43/222 (19%), Positives = 94/222 (42%), Gaps = 18/222 (8%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVL 108
A+ +AE+ +++T L + EK +E+ L+D+LDE L L++
Sbjct: 1374 ANRKAEQDMRELTYELNALQLEKTS-----SEEKARLLKDKLDETNNTLR-----CLKLE 1423
Query: 109 RASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYG 168
+Q ++ + RE +T + A +A + + + RNY+ ++
Sbjct: 1424 LERKDQAEKGYSQQLRELGRQLNQTTGK------AEEAMQEASDLKKIKRNYQLELESLN 1477
Query: 169 SPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKE--KNLILEEKITTLQQENEDL 226
++E++ + + + I L+ ++ KE + I + K L+++ E
Sbjct: 1478 HEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKS 1537
Query: 227 HVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
H + + ++ ++ + E LEK + L+Q+ EEL
Sbjct: 1538 HEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEEL 1579
Score = 40.8 bits (94), Expect = 0.001
Identities = 53/277 (19%), Positives = 128/277 (46%), Gaps = 56/277 (20%)
Query: 46 QLCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEAL 105
QL + +AE+ D + L + E+ + A+ ++++ E EL + +E + +++ E+
Sbjct: 1540 QLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVE-ELTRQNNETKLMMQRIQAESE 1598
Query: 106 QVL--RASYEQEKEAL---THSFREASSTQQETIDRLTSQLEAFQAKMKRVEE------- 153
++ + + +Q EAL F++ + E + + T + FQ K+K +EE
Sbjct: 1599 NIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQN 1658
Query: 154 ------------SILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRL-- 199
+I+ +N KK +++ + ++E ++++ ++ EL+ RL
Sbjct: 1659 LVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKK 1718
Query: 200 ----ILMETVKE-----KNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSED----LLL 246
+ ++T++E K ++ +E+ +Q E+ + +++ S+ ++E+ + L
Sbjct: 1719 VQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFR-KKMEKLMESKVITENDISGIRL 1777
Query: 247 TREALEKE---------------VQLRRQLQQEKEEL 268
+L++E +L RQLQQ +E++
Sbjct: 1778 DFVSLQQENSRAQENAKLCETNIKELERQLQQYREQM 1814
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 53.9 bits (128), Expect = 2e-07
Identities = 65/272 (23%), Positives = 119/272 (43%), Gaps = 41/272 (15%)
Query: 13 PPKKKRQEPEPE-------QPPRPEPHELGPLNGDTAITV-----QLCASEEAERHQKDI 60
P +K QE EP+ + R +E G + + Q A +A++ +++
Sbjct: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW 404
Query: 61 TRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALT 120
R +Q E ++++W +Q+E E+ LE + L+ Q+ K+ E + + E+++
Sbjct: 405 ER--KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
Query: 121 HSFR-----EASSTQQETIDRLTS-------QLEAFQAKMKRVEESILSRNYKKHIQDYG 168
R + +QE I RL S +LEA K +++ + KK Q
Sbjct: 463 ERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQK-- 520
Query: 169 SPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENED--- 225
+ + +++ + I+ + + E +LI + V EK L L E+I +Q N
Sbjct: 521 TELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYL--VPEKQL-LNERIKNMQFSNTPDSG 577
Query: 226 ---LHVRSRNQVVLSRQLSEDLLLTREALEKE 254
LH +S + L ++L E L +ALEKE
Sbjct: 578 VSLLHKKSLEKEELCQRLKEQL----DALEKE 605
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 53.9 bits (128), Expect = 2e-07
Identities = 65/272 (23%), Positives = 119/272 (43%), Gaps = 41/272 (15%)
Query: 13 PPKKKRQEPEPE-------QPPRPEPHELGPLNGDTAITV-----QLCASEEAERHQKDI 60
P +K QE EP+ + R +E G + + Q A +A++ +++
Sbjct: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW 404
Query: 61 TRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALT 120
R +Q E ++++W +Q+E E+ LE + L+ Q+ K+ E + + E+++
Sbjct: 405 ER--KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
Query: 121 HSFR-----EASSTQQETIDRLTS-------QLEAFQAKMKRVEESILSRNYKKHIQDYG 168
R + +QE I RL S +LEA K +++ + KK Q
Sbjct: 463 ERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQK-- 520
Query: 169 SPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENED--- 225
+ + +++ + I+ + + E +LI + V EK L L E+I +Q N
Sbjct: 521 TELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYL--VPEKQL-LNERIKNMQFSNTPDSG 577
Query: 226 ---LHVRSRNQVVLSRQLSEDLLLTREALEKE 254
LH +S + L ++L E L +ALEKE
Sbjct: 578 VSLLHKKSLEKEELCQRLKEQL----DALEKE 605
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 53.9 bits (128), Expect = 2e-07
Identities = 65/272 (23%), Positives = 119/272 (43%), Gaps = 41/272 (15%)
Query: 13 PPKKKRQEPEPE-------QPPRPEPHELGPLNGDTAITV-----QLCASEEAERHQKDI 60
P +K QE EP+ + R +E G + + Q A +A++ +++
Sbjct: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW 404
Query: 61 TRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALT 120
R +Q E ++++W +Q+E E+ LE + L+ Q+ K+ E + + E+++
Sbjct: 405 ER--KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
Query: 121 HSFR-----EASSTQQETIDRLTS-------QLEAFQAKMKRVEESILSRNYKKHIQDYG 168
R + +QE I RL S +LEA K +++ + KK Q
Sbjct: 463 ERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQK-- 520
Query: 169 SPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENED--- 225
+ + +++ + I+ + + E +LI + V EK L L E+I +Q N
Sbjct: 521 TELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYL--VPEKQL-LNERIKNMQFSNTPDSG 577
Query: 226 ---LHVRSRNQVVLSRQLSEDLLLTREALEKE 254
LH +S + L ++L E L +ALEKE
Sbjct: 578 VSLLHKKSLEKEELCQRLKEQL----DALEKE 605
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 53.5 bits (127), Expect = 2e-07
Identities = 64/267 (23%), Positives = 115/267 (43%), Gaps = 28/267 (10%)
Query: 15 KKKRQEPEPEQPPRPE-PHELGPLNGDTAITVQLCASE----EAERHQKDITRILQQHEE 69
K K Q EP P P P ++ L +T + S +AE + +L + +E
Sbjct: 139 KLKNQTAEPLAPEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQE 198
Query: 70 EKKKWAQQVEKERELELRD---RLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFREA 126
E+ + ++ +E+E LR+ RL EQ+ L + E + EQE+ H E
Sbjct: 199 ERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREH--EER 256
Query: 127 SSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIE 186
Q+E + +L + ++ EE + + + Q+ Q E+ L +
Sbjct: 257 LCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQ--EERLREQEERLC 314
Query: 187 MKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLL 246
+ ER+ E + RL E + + +LEE L+QE RQ ++ LL
Sbjct: 315 EQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQER--------------RQEEQERLL 360
Query: 247 TREALEKEVQ--LRRQLQQEKEELLYR 271
RE L +EV+ L ++ ++++E L++
Sbjct: 361 ERERLLEEVEELLEQERLRQQDERLWQ 387
Score = 39.3 bits (90), Expect = 0.004
Identities = 53/220 (24%), Positives = 95/220 (43%), Gaps = 43/220 (19%)
Query: 46 QLCASEEAERHQKDITRILQQHE---EEKKKWAQQVEK-----ERELELRDRLDEQQRVL 97
+LC EE R ++ R+ +Q E E++++ +Q E+ ER E +RL EQ+ L
Sbjct: 242 RLCEQEERLREHEE--RLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERL 299
Query: 98 EGKNEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEES--I 155
+ E + EQE+ R + +RL ++E + +R EE +
Sbjct: 300 CEQEERLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERL 359
Query: 156 LSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILE-E 214
L R E+ LE + ++E ER+ + D RL ET++E + E E
Sbjct: 360 LER----------------ERLLEEVEELLE--QERLRQQDERLWQQETLQELERLRELE 401
Query: 215 KITTLQQEN------------EDLHVRSRNQVVLSRQLSE 242
++ L E E+L+ +++ + L +Q+ E
Sbjct: 402 RMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKE 441
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 52.8 bits (125), Expect = 4e-07
Identities = 58/246 (23%), Positives = 121/246 (49%), Gaps = 41/246 (16%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQQVE------KERELELRDRLD--EQQRVLEGKNE 102
++ E + R + ++KK +++E KE+ +++ + EQ +++ ++E
Sbjct: 1571 QKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSE 1630
Query: 103 EALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYK- 161
+ L+ Q+++ L RE TQ+E + RL+S++EA + ++ + +ES+ + +
Sbjct: 1631 DDLR-------QQRDVLDGHLREKQRTQEE-LRRLSSEVEALRRQLLQEQESVKQAHLRN 1682
Query: 162 KHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQ 221
+H Q + E + SL NE E++R L E + +++L+LEE++ L+
Sbjct: 1683 EHFQ------KAIEDKSRSL-------NESKIEIERLQSLTENLTKEHLMLEEELRNLRL 1729
Query: 222 ENEDLH------VRSRNQVVL----SRQLSEDLLLTREALEKEVQLRRQ-LQQEKEELLY 270
E +DL +N +L Q+S + L + L ++Q R+ L+QE E+
Sbjct: 1730 EYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQK 1789
Query: 271 RVLGAN 276
+ L A+
Sbjct: 1790 QALEAS 1795
Score = 42.4 bits (98), Expect = 5e-04
Identities = 50/262 (19%), Positives = 113/262 (43%), Gaps = 36/262 (13%)
Query: 40 DTAITVQLCASEEAERHQK---DITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRV 96
+ A+ + C SE ++ Q ++ +++QQ E+ + Q +E E ++D+ E +R+
Sbjct: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE-EAAKTIQDKNKEIERL 1330
Query: 97 LEGKNEEA---------LQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAK 147
EEA L +R +Y++E +L + F + + TI +LT Q E
Sbjct: 1331 KAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEED--- 1387
Query: 148 MKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMET--- 204
+ Y+ I + ++ +E++ L + E + ++ + +
Sbjct: 1388 ---------TSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS 1438
Query: 205 -VKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSED----LLLTREALEKEVQLRR 259
V ++ LE ++ + Q + VR + + + + +D + ++ ++KE R+
Sbjct: 1439 EVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRK 1498
Query: 260 QLQQEK---EELLYRVLGANAS 278
L+ E + + Y + AN+S
Sbjct: 1499 CLEDENARLQRVQYDLQKANSS 1520
Score = 41.6 bits (96), Expect = 8e-04
Identities = 57/261 (21%), Positives = 113/261 (43%), Gaps = 46/261 (17%)
Query: 50 SEEAERHQKDI----TRILQQHEEEKKKWAQQVEKERELELRD---------RLDEQQRV 96
SE+ R Q+D+ R Q+ +EE ++ + +VE R L++ R + Q+
Sbjct: 1629 SEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKA 1688
Query: 97 LEGKNE---------EALQVLRASYEQEKEALTHSFR--------------EASSTQQET 133
+E K+ E LQ L + +E L R EA S + T
Sbjct: 1689 IEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNAT 1748
Query: 134 IDRLTSQLEAFQAKMKRVEESI--LSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNER 191
I L SQL+ + ++ I L R + Q+ +F +Q LE+ + + E KN+
Sbjct: 1749 ILELRSQLQISNNRTLELQGLINDLQRERENLRQEI---EKFQKQALEASNRIQESKNQC 1805
Query: 192 IHELDRRLILMETVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREAL 251
+ R L+ +K +LE+ LQ+ ++L+ R+++ + ++ + L ++ +
Sbjct: 1806 TQVVQERESLLVKIK----VLEQDKARLQRLEDELN-RAKSTLEAETRVKQRLECEKQQI 1860
Query: 252 EKEVQLRRQLQQEKEELLYRV 272
+ ++ + KEE + ++
Sbjct: 1861 QNDLNQWKTQYSRKEEAIRKI 1881
Score = 37.0 bits (84), Expect = 0.021
Identities = 28/119 (23%), Positives = 57/119 (47%), Gaps = 15/119 (12%)
Query: 49 ASEEAERHQKDITRILQQHE---------EEKKKWAQQVEKERE-----LELRDRLDEQQ 94
AS + + T+++Q+ E E+ K Q++E E LE R+ ++
Sbjct: 1794 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1853
Query: 95 RVLEGKNEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEE 153
+ + + L + Y +++EA+ E +++E + L S++E QA++KR+EE
Sbjct: 1854 ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK-NSLRSEIERLQAEIKRIEE 1911
Score = 35.4 bits (80), Expect = 0.061
Identities = 52/258 (20%), Positives = 106/258 (41%), Gaps = 46/258 (17%)
Query: 52 EAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVL---EGKN----EEA 104
+ +++ D + +Q E+E W Q++E E+ ++ ++ E+ RVL EG E
Sbjct: 1133 DQQKNDYDQLQKARQCEKENLGW-QKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENE 1191
Query: 105 LQVLRASYEQEKEALTHSF------------------REASSTQQETIDRLTSQLEAFQA 146
L +R Y +E L + + + S + +DRL+ + +
Sbjct: 1192 LAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKD 1251
Query: 147 KMKRVEESILS------RNYKKHIQDYGSPSQFWEQELESLHFVIEMK---NERIHELDR 197
++ R+ +SIL R + +Q S+ +++ H IE+K +R + R
Sbjct: 1252 EIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKK---QHLEIELKQVMQQRSEDNAR 1308
Query: 198 RLILME----TVKEKNLILEEKITTLQQENEDLHVRSRNQVVLSRQLSEDLLLTREALEK 253
+E T+++KN +E Q+E + + E+++ + E
Sbjct: 1309 HKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFET 1368
Query: 254 EVQLRR----QLQQEKEE 267
E+ + + QL +KEE
Sbjct: 1369 EINITKTTIHQLTMQKEE 1386
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 52.8 bits (125), Expect = 4e-07
Identities = 63/292 (21%), Positives = 130/292 (44%), Gaps = 60/292 (20%)
Query: 19 QEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQQV 78
Q + P+ EP EL P + D ++ Q AS+ ++ +I + E E+++ ++
Sbjct: 521 QSQSSTEDPKDEPAELKPDSED--LSSQSSASKASQEDANEIKSKRDEEERERERREKER 578
Query: 79 EKERELEL-RDRLDEQQRVLE------------------GKNEEALQV------LRASYE 113
E+ERE E ++R E+Q++ E G+ +EA + L+ + E
Sbjct: 579 EREREREKEKEREREKQKLKESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQE 638
Query: 114 QEKEA--LTHSFREASSTQQETIDRLTSQ------LEAFQAKMKRVEESILSRNYKKHIQ 165
+KE L +R A Q++ + + ++ LE + ++K +E+ N K +
Sbjct: 639 SQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADE 698
Query: 166 DYGSPSQFWEQELESLHFVIEMKNER----IHELDRRLILMETVKEKNLILEEKITTLQQ 221
D + E+++E L + M + + E+D E ++E+N+ L +++ +
Sbjct: 699 DALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQL----R 754
Query: 222 ENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVL 273
E +D + + ++ + S Q+ + L++EKEEL +VL
Sbjct: 755 EKDDANFKLMSERIKSNQI-----------------HKLLKEEKEELADQVL 789
Score = 36.6 bits (83), Expect = 0.027
Identities = 43/224 (19%), Positives = 97/224 (43%), Gaps = 21/224 (9%)
Query: 47 LCASEEAERHQKDITRILQQHEEE--KKKWAQQVEKERELELRDRLDEQQRVLEGKNEEA 104
L S+ + KD L+ E+ + A + +E E++ + DE++R E + +E
Sbjct: 519 LLQSQSSTEDPKDEPAELKPDSEDLSSQSSASKASQEDANEIKSKRDEEERERERREKER 578
Query: 105 LQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHI 164
+ E+E+E +E+ + D+ E + R +E+ + + K +
Sbjct: 579 EREREREKEKEREREKQKLKESEKERDSAKDK-----EKGKHDDGRKKEAEIIKQLKIEL 633
Query: 165 QDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENE 224
+ ++ + + +++M E ++ LM K+ LE+ L+Q +
Sbjct: 634 KKA-------QESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELED----LRQRLK 682
Query: 225 DLHVRSRNQVVLSRQLSEDLLLTREALEKEVQ-LRRQLQQEKEE 267
DL + + + + ED L A+E++++ L+++L K+E
Sbjct: 683 DLEDKEKKE--NKKMADEDALRKIRAVEEQIEYLQKKLAMAKQE 724
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 52.8 bits (125), Expect = 4e-07
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 26/229 (11%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVL--------EGK 100
A E+A R Q+D ++ QQ EE + + + +E ER+ +L + ++ L + +
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398
Query: 101 NEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNY 160
EE Q R E+ E L H A+ + + L Q + +R+ E+I
Sbjct: 2399 AEEDAQRFRKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457
Query: 161 KKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQ 220
+K ++L+ ++++K+E + + + +L ET + L EK + LQ
Sbjct: 2458 EK-------------EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 221 QENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELL 269
+E + + L + +++ ++ E++ + ++Q++QE++ L+
Sbjct: 2505 RE----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Score = 51.6 bits (122), Expect = 8e-07
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 35/277 (12%)
Query: 17 KRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAE--------------RHQKDITR 62
+++E E +Q + E L L G+ + A+EEAE R ++ R
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARR--AAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 63 ILQQHEEEKKKWAQ------QVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEK 116
+ Q EE+ + AQ ++ KE E E R +Q L K Q A E+ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-----QAADAEMEKHK 2171
Query: 117 EALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQ 176
+ + R+ + +QE + L QLE + ++E + + K + E+
Sbjct: 2172 KFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLDEEL--QRLKAEATEAARQRSQVEE 2228
Query: 177 ELESLHFVIEMKNE---RIHELDRRLILMETVKEKNLILEE--KITTLQQENEDLHVRSR 231
EL S+ +E ++ RI +R LIL + + + EE K+ + +E L V ++
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288
Query: 232 NQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
L + EDL R EK ++ + Q QE L
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Score = 43.9 bits (102), Expect = 2e-04
Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 46/294 (15%)
Query: 15 KKKRQEPEPEQPPRPEPHELG--PLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKK 72
++ +Q+ E E+ EL L + A+ ++L A E A++ +Q EE ++
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 73 ------KWAQQVEKERELELRDRLDEQQRVLEGKNEEALQV------LRASYEQE----- 115
K +Q ++REL L++Q+++ EG ++ L LRA EQ
Sbjct: 1672 EARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 116 --KEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQF 173
+E L REA++ Q+ +LEA AK+ R E +L + + ++ S S+
Sbjct: 1731 LLEEELARLQREAAAATQK-----RQELEAELAKV-RAEMEVLLASKARAEEESRSTSEK 1784
Query: 174 WEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQE----------- 222
+Q LE+ E E R L E K + + EE + E
Sbjct: 1785 SKQRLEA---EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 223 -NEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRR---QLQQEKEELLYRV 272
E +++ ++ L + +E+ L R A ++ Q RR Q Q K ++ R+
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Score = 39.3 bits (90), Expect = 0.004
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 14/217 (6%)
Query: 66 QHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFRE 125
Q E E K+ Q++++E +D QQ+ + +E LQ LR S E E +A
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 126 ASSTQ---QETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLH 182
A ++ +E I + QLEA + + E + + + ++ + + ++E E L
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA--LRARAEEAEAQKRQAQEEAERLR 1500
Query: 183 FVIEMKNERIHELDRRLILM-----ETVKEKNLILEEKITTLQQENEDLHVRSRN-QVVL 236
++ +++R + + L E +EK L + + L+ + E+ R R +V
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVER 1559
Query: 237 SRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVL 273
+RQ+ L + + E E+Q +R EK L R L
Sbjct: 1560 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Score = 37.4 bits (85), Expect = 0.016
Identities = 55/247 (22%), Positives = 105/247 (42%), Gaps = 31/247 (12%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQ-QVEKERELELRDRLDEQQRVLEGKNEEALQV-- 107
EE R Q++ Q+ +E + + A+ + E E L + R +E+ R K+++ L+
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793
Query: 108 ------------LRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAF--------QAK 147
LRA E+ K + +A+ + E L +L A +A+
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 148 MKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH-----ELDRRLILM 202
+ E+ + ++ +D + E++ IE + ++ EL+R+ L+
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 203 ETVKEKNLILEEKITTLQQENEDLHV-RSRNQVVLSRQLS--EDLLLTREALEKEVQLRR 259
E + +EE+I L+ E ++ ++ L R S ED L ++E E E +R
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 260 QLQQEKE 266
QL E+E
Sbjct: 1974 QLAAEEE 1980
Score = 36.6 bits (83), Expect = 0.027
Identities = 54/253 (21%), Positives = 102/253 (40%), Gaps = 31/253 (12%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVL 108
A E+A R + + R+L + + A +++ E E+ L+++ E +R+ +EA Q
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1878
Query: 109 RASYE--QEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
R + Q K + + ++R +E + ++VEE IL+ K +
Sbjct: 1879 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEK 1936
Query: 167 YGSPSQFWEQEL--------------ESLHFVIEMKNERIHELDRRLILMETVKEKNLIL 212
+ E EL E + + E +RR E +K+L
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 213 EEKITTLQQENEDLHVRSRNQVVLSRQLSE--------DLLLTREALEKEVQLRRQLQ-- 262
EE+ ++ + R + +V +R+L E L L +EA +K +Q +
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 263 --QEKEELLYRVL 273
Q+KE+ L + L
Sbjct: 2057 AVQQKEQELQQTL 2069
Score = 35.0 bits (79), Expect = 0.079
Identities = 59/244 (24%), Positives = 100/244 (40%), Gaps = 35/244 (14%)
Query: 50 SEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLR 109
S EAE K + + + E+ + V + E +R +QQ E EEA + L
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 110 ASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGS 169
+ EAL + QQ+++ +Q EA + K + E +R K +
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSL----AQAEAEKQKEEAERE---ARRRGKAEEQAVR 1685
Query: 170 PSQFWEQELESLHFVIEMKNERIHELDRRLILM----ETVKEKNLILEEKITTLQQ---- 221
+ EQELE + E ++ ++ LI + E +++ +LEE++ LQ+
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 222 --------ENEDLHVRSRNQVVL---------SRQLSEDLLLTREALEKEVQLRRQLQQE 264
E E VR+ +V+L SR SE +++ LE E R+L +E
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEE 1802
Query: 265 KEEL 268
L
Sbjct: 1803 AARL 1806
Score = 35.0 bits (79), Expect = 0.079
Identities = 55/246 (22%), Positives = 95/246 (38%), Gaps = 57/246 (23%)
Query: 47 LCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQ 106
+ + EEA R Q + +++ +EE QQ+E++R +Q+ +L +N+ +
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRR--------QQEELLAEENQRLRE 2596
Query: 107 VLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
L+ EQ + AL HS E +++Q L + +A E
Sbjct: 2597 QLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEP------------- 2642
Query: 167 YGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDL 226
E + L RR + + ++E ++ E++ L Q + +
Sbjct: 2643 --------EHSFDGL---------------RRKVSAQRLQEAGILSAEELQRLAQGHTTV 2679
Query: 227 HVRSRNQVV----LSRQLSEDLLL--TREALEKEVQLRRQLQQEKEELLYRVLGANASPA 280
+R + V R LLL T E L L+RQL L+ +L A A+
Sbjct: 2680 DELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALI--LLEAQAASG 2737
Query: 281 FPLAPV 286
F L PV
Sbjct: 2738 FLLDPV 2743
Score = 29.3 bits (64), Expect = 4.3
Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 71/321 (22%)
Query: 18 RQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQQ 77
R E + + P L L A +L A EA++ D R + +E + QQ
Sbjct: 1106 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1165
Query: 78 VEKERELEL---RDRL--------------DEQQRVLEGKNEEA-------------LQV 107
ER++E+ R+R+ D +QR LE + LQ
Sbjct: 1166 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225
Query: 108 LRASYEQ-------EKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSR-- 158
R EQ + +A+ R+ + +E I+R ++E Q K+ +I
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 159 ---NYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH---------------------- 193
YK ++ SP++ + + S + E + R H
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 194 ELDRRLILMETVKEKNLILE-EKITTLQQENEDLHVRSRNQV-----VLSRQLSEDLLLT 247
E + RL + +E+ + E E Q++ + H +++ Q L +++ E+++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 248 REALEKEVQLRRQLQQEKEEL 268
EA Q +R +Q+E ++L
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQL 1425
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 52.8 bits (125), Expect = 4e-07
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 26/229 (11%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVL--------EGK 100
A E+A R Q+D ++ QQ EE + + + +E ER+ +L + ++ L + +
Sbjct: 2343 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2402
Query: 101 NEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNY 160
EE Q R E+ E L H A+ + + L Q + +R+ E+I
Sbjct: 2403 AEEDAQRFRKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2461
Query: 161 KKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQ 220
+K ++L+ ++++K+E + + + +L ET + L EK + LQ
Sbjct: 2462 EK-------------EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2508
Query: 221 QENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELL 269
+E + + L + +++ ++ E++ + ++Q++QE++ L+
Sbjct: 2509 RE----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Score = 51.6 bits (122), Expect = 8e-07
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 35/277 (12%)
Query: 17 KRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAE--------------RHQKDITR 62
+++E E +Q + E L L G+ + A+EEAE R ++ R
Sbjct: 2063 QQKEQELQQTLQQEQSVLDQLRGEAEAARR--AAEEAEEARVQAEREAAQSRRQVEEAER 2120
Query: 63 ILQQHEEEKKKWAQ------QVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEK 116
+ Q EE+ + AQ ++ KE E E R +Q L K Q A E+ K
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-----QAADAEMEKHK 2175
Query: 117 EALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQ 176
+ + R+ + +QE + L QLE + ++E + + K + E+
Sbjct: 2176 KFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLDEEL--QRLKAEATEAARQRSQVEE 2232
Query: 177 ELESLHFVIEMKNE---RIHELDRRLILMETVKEKNLILEE--KITTLQQENEDLHVRSR 231
EL S+ +E ++ RI +R LIL + + + EE K+ + +E L V ++
Sbjct: 2233 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2292
Query: 232 NQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
L + EDL R EK ++ + Q QE L
Sbjct: 2293 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Score = 43.9 bits (102), Expect = 2e-04
Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 46/294 (15%)
Query: 15 KKKRQEPEPEQPPRPEPHELG--PLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKK 72
++ +Q+ E E+ EL L + A+ ++L A E A++ +Q EE ++
Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 73 ------KWAQQVEKERELELRDRLDEQQRVLEGKNEEALQV------LRASYEQE----- 115
K +Q ++REL L++Q+++ EG ++ L LRA EQ
Sbjct: 1676 EARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734
Query: 116 --KEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQF 173
+E L REA++ Q+ +LEA AK+ R E +L + + ++ S S+
Sbjct: 1735 LLEEELARLQREAAAATQK-----RQELEAELAKV-RAEMEVLLASKARAEEESRSTSEK 1788
Query: 174 WEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQE----------- 222
+Q LE+ E E R L E K + + EE + E
Sbjct: 1789 SKQRLEA---EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845
Query: 223 -NEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRR---QLQQEKEELLYRV 272
E +++ ++ L + +E+ L R A ++ Q RR Q Q K ++ R+
Sbjct: 1846 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899
Score = 39.3 bits (90), Expect = 0.004
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 14/217 (6%)
Query: 66 QHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFRE 125
Q E E K+ Q++++E +D QQ+ + +E LQ LR S E E +A
Sbjct: 1389 QAEREAKELQQRMQEEVVRREEAAVDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEA 1446
Query: 126 ASSTQ---QETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLH 182
A ++ +E I + QLEA + + E + + + ++ + + ++E E L
Sbjct: 1447 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA--LRARAEEAEAQKRQAQEEAERLR 1504
Query: 183 FVIEMKNERIHELDRRLILM-----ETVKEKNLILEEKITTLQQENEDLHVRSRN-QVVL 236
++ +++R + + L E +EK L + + L+ + E+ R R +V
Sbjct: 1505 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVER 1563
Query: 237 SRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVL 273
+RQ+ L + + E E+Q +R EK L R L
Sbjct: 1564 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Score = 37.4 bits (85), Expect = 0.016
Identities = 55/247 (22%), Positives = 105/247 (42%), Gaps = 31/247 (12%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQ-QVEKERELELRDRLDEQQRVLEGKNEEALQV-- 107
EE R Q++ Q+ +E + + A+ + E E L + R +E+ R K+++ L+
Sbjct: 1738 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1797
Query: 108 ------------LRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAF--------QAK 147
LRA E+ K + +A+ + E L +L A +A+
Sbjct: 1798 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1857
Query: 148 MKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH-----ELDRRLILM 202
+ E+ + ++ +D + E++ IE + ++ EL+R+ L+
Sbjct: 1858 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1917
Query: 203 ETVKEKNLILEEKITTLQQENEDLHV-RSRNQVVLSRQLS--EDLLLTREALEKEVQLRR 259
E + +EE+I L+ E ++ ++ L R S ED L ++E E E +R
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977
Query: 260 QLQQEKE 266
QL E+E
Sbjct: 1978 QLAAEEE 1984
Score = 36.6 bits (83), Expect = 0.027
Identities = 54/253 (21%), Positives = 102/253 (40%), Gaps = 31/253 (12%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVL 108
A E+A R + + R+L + + A +++ E E+ L+++ E +R+ +EA Q
Sbjct: 1824 AEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1882
Query: 109 RASYE--QEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
R + Q K + + ++R +E + ++VEE IL+ K +
Sbjct: 1883 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEK 1940
Query: 167 YGSPSQFWEQEL--------------ESLHFVIEMKNERIHELDRRLILMETVKEKNLIL 212
+ E EL E + + E +RR E +K+L
Sbjct: 1941 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2000
Query: 213 EEKITTLQQENEDLHVRSRNQVVLSRQLSE--------DLLLTREALEKEVQLRRQLQ-- 262
EE+ ++ + R + +V +R+L E L L +EA +K +Q +
Sbjct: 2001 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2060
Query: 263 --QEKEELLYRVL 273
Q+KE+ L + L
Sbjct: 2061 AVQQKEQELQQTL 2073
Score = 35.0 bits (79), Expect = 0.079
Identities = 59/244 (24%), Positives = 100/244 (40%), Gaps = 35/244 (14%)
Query: 50 SEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLR 109
S EAE K + + + E+ + V + E +R +QQ E EEA + L
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Query: 110 ASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGS 169
+ EAL + QQ+++ +Q EA + K + E +R K +
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSL----AQAEAEKQKEEAERE---ARRRGKAEEQAVR 1689
Query: 170 PSQFWEQELESLHFVIEMKNERIHELDRRLILM----ETVKEKNLILEEKITTLQQ---- 221
+ EQELE + E ++ ++ LI + E +++ +LEE++ LQ+
Sbjct: 1690 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1749
Query: 222 --------ENEDLHVRSRNQVVL---------SRQLSEDLLLTREALEKEVQLRRQLQQE 264
E E VR+ +V+L SR SE +++ LE E R+L +E
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEE 1806
Query: 265 KEEL 268
L
Sbjct: 1807 AARL 1810
Score = 35.0 bits (79), Expect = 0.079
Identities = 55/246 (22%), Positives = 95/246 (38%), Gaps = 57/246 (23%)
Query: 47 LCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQ 106
+ + EEA R Q + +++ +EE QQ+E++R +Q+ +L +N+ +
Sbjct: 2553 VASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRR--------QQEELLAEENQRLRE 2600
Query: 107 VLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
L+ EQ + AL HS E +++Q L + +A E
Sbjct: 2601 QLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEP------------- 2646
Query: 167 YGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDL 226
E + L RR + + ++E ++ E++ L Q + +
Sbjct: 2647 --------EHSFDGL---------------RRKVSAQRLQEAGILSAEELQRLAQGHTTV 2683
Query: 227 HVRSRNQVV----LSRQLSEDLLL--TREALEKEVQLRRQLQQEKEELLYRVLGANASPA 280
+R + V R LLL T E L L+RQL L+ +L A A+
Sbjct: 2684 DELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALI--LLEAQAASG 2741
Query: 281 FPLAPV 286
F L PV
Sbjct: 2742 FLLDPV 2747
Score = 29.3 bits (64), Expect = 4.3
Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 71/321 (22%)
Query: 18 RQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQQ 77
R E + + P L L A +L A EA++ D R + +E + QQ
Sbjct: 1110 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1169
Query: 78 VEKERELEL---RDRL--------------DEQQRVLEGKNEEA-------------LQV 107
ER++E+ R+R+ D +QR LE + LQ
Sbjct: 1170 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1229
Query: 108 LRASYEQ-------EKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSR-- 158
R EQ + +A+ R+ + +E I+R ++E Q K+ +I
Sbjct: 1230 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAIKDYEL 1288
Query: 159 ---NYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH---------------------- 193
YK ++ SP++ + + S + E + R H
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348
Query: 194 ELDRRLILMETVKEKNLILE-EKITTLQQENEDLHVRSRNQV-----VLSRQLSEDLLLT 247
E + RL + +E+ + E E Q++ + H +++ Q L +++ E+++
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 248 REALEKEVQLRRQLQQEKEEL 268
EA Q +R +Q+E ++L
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQL 1429
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 52.8 bits (125), Expect = 4e-07
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 26/229 (11%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVL--------EGK 100
A E+A R Q+D ++ QQ EE + + + +E ER+ +L + ++ L + +
Sbjct: 2339 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2398
Query: 101 NEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNY 160
EE Q R E+ E L H A+ + + L Q + +R+ E+I
Sbjct: 2399 AEEDAQRFRKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457
Query: 161 KKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQ 220
+K ++L+ ++++K+E + + + +L ET + L EK + LQ
Sbjct: 2458 EK-------------EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2504
Query: 221 QENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELL 269
+E + + L + +++ ++ E++ + ++Q++QE++ L+
Sbjct: 2505 RE----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Score = 51.6 bits (122), Expect = 8e-07
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 35/277 (12%)
Query: 17 KRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAE--------------RHQKDITR 62
+++E E +Q + E L L G+ + A+EEAE R ++ R
Sbjct: 2059 QQKEQELQQTLQQEQSVLDQLRGEAEAARR--AAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 63 ILQQHEEEKKKWAQ------QVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEK 116
+ Q EE+ + AQ ++ KE E E R +Q L K Q A E+ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-----QAADAEMEKHK 2171
Query: 117 EALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQ 176
+ + R+ + +QE + L QLE + ++E + + K + E+
Sbjct: 2172 KFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLDEEL--QRLKAEATEAARQRSQVEE 2228
Query: 177 ELESLHFVIEMKNE---RIHELDRRLILMETVKEKNLILEE--KITTLQQENEDLHVRSR 231
EL S+ +E ++ RI +R LIL + + + EE K+ + +E L V ++
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288
Query: 232 NQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
L + EDL R EK ++ + Q QE L
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Score = 43.9 bits (102), Expect = 2e-04
Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 46/294 (15%)
Query: 15 KKKRQEPEPEQPPRPEPHELG--PLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKK 72
++ +Q+ E E+ EL L + A+ ++L A E A++ +Q EE ++
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 73 ------KWAQQVEKERELELRDRLDEQQRVLEGKNEEALQV------LRASYEQE----- 115
K +Q ++REL L++Q+++ EG ++ L LRA EQ
Sbjct: 1672 EARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 116 --KEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQF 173
+E L REA++ Q+ +LEA AK+ R E +L + + ++ S S+
Sbjct: 1731 LLEEELARLQREAAAATQK-----RQELEAELAKV-RAEMEVLLASKARAEEESRSTSEK 1784
Query: 174 WEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQE----------- 222
+Q LE+ E E R L E K + + EE + E
Sbjct: 1785 SKQRLEA---EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 223 -NEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRR---QLQQEKEELLYRV 272
E +++ ++ L + +E+ L R A ++ Q RR Q Q K ++ R+
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Score = 39.3 bits (90), Expect = 0.004
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 14/217 (6%)
Query: 66 QHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFRE 125
Q E E K+ Q++++E +D QQ+ + +E LQ LR S E E +A
Sbjct: 1385 QAEREAKELQQRMQEEVVRREEAAVDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEA 1442
Query: 126 ASSTQ---QETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLH 182
A ++ +E I + QLEA + + E + + + ++ + + ++E E L
Sbjct: 1443 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA--LRARAEEAEAQKRQAQEEAERLR 1500
Query: 183 FVIEMKNERIHELDRRLILM-----ETVKEKNLILEEKITTLQQENEDLHVRSRN-QVVL 236
++ +++R + + L E +EK L + + L+ + E+ R R +V
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVER 1559
Query: 237 SRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVL 273
+RQ+ L + + E E+Q +R EK L R L
Sbjct: 1560 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Score = 37.4 bits (85), Expect = 0.016
Identities = 55/247 (22%), Positives = 105/247 (42%), Gaps = 31/247 (12%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQ-QVEKERELELRDRLDEQQRVLEGKNEEALQV-- 107
EE R Q++ Q+ +E + + A+ + E E L + R +E+ R K+++ L+
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1793
Query: 108 ------------LRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAF--------QAK 147
LRA E+ K + +A+ + E L +L A +A+
Sbjct: 1794 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1853
Query: 148 MKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH-----ELDRRLILM 202
+ E+ + ++ +D + E++ IE + ++ EL+R+ L+
Sbjct: 1854 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913
Query: 203 ETVKEKNLILEEKITTLQQENEDLHV-RSRNQVVLSRQLS--EDLLLTREALEKEVQLRR 259
E + +EE+I L+ E ++ ++ L R S ED L ++E E E +R
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973
Query: 260 QLQQEKE 266
QL E+E
Sbjct: 1974 QLAAEEE 1980
Score = 36.6 bits (83), Expect = 0.027
Identities = 54/253 (21%), Positives = 102/253 (40%), Gaps = 31/253 (12%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVL 108
A E+A R + + R+L + + A +++ E E+ L+++ E +R+ +EA Q
Sbjct: 1820 AEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1878
Query: 109 RASYE--QEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
R + Q K + + ++R +E + ++VEE IL+ K +
Sbjct: 1879 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEK 1936
Query: 167 YGSPSQFWEQEL--------------ESLHFVIEMKNERIHELDRRLILMETVKEKNLIL 212
+ E EL E + + E +RR E +K+L
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 213 EEKITTLQQENEDLHVRSRNQVVLSRQLSE--------DLLLTREALEKEVQLRRQLQ-- 262
EE+ ++ + R + +V +R+L E L L +EA +K +Q +
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 263 --QEKEELLYRVL 273
Q+KE+ L + L
Sbjct: 2057 AVQQKEQELQQTL 2069
Score = 35.0 bits (79), Expect = 0.079
Identities = 59/244 (24%), Positives = 100/244 (40%), Gaps = 35/244 (14%)
Query: 50 SEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLR 109
S EAE K + + + E+ + V + E +R +QQ E EEA + L
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Query: 110 ASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGS 169
+ EAL + QQ+++ +Q EA + K + E +R K +
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSL----AQAEAEKQKEEAERE---ARRRGKAEEQAVR 1685
Query: 170 PSQFWEQELESLHFVIEMKNERIHELDRRLILM----ETVKEKNLILEEKITTLQQ---- 221
+ EQELE + E ++ ++ LI + E +++ +LEE++ LQ+
Sbjct: 1686 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 222 --------ENEDLHVRSRNQVVL---------SRQLSEDLLLTREALEKEVQLRRQLQQE 264
E E VR+ +V+L SR SE +++ LE E R+L +E
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEE 1802
Query: 265 KEEL 268
L
Sbjct: 1803 AARL 1806
Score = 35.0 bits (79), Expect = 0.079
Identities = 55/246 (22%), Positives = 95/246 (38%), Gaps = 57/246 (23%)
Query: 47 LCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQ 106
+ + EEA R Q + +++ +EE QQ+E++R +Q+ +L +N+ +
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRR--------QQEELLAEENQRLRE 2596
Query: 107 VLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
L+ EQ + AL HS E +++Q L + +A E
Sbjct: 2597 QLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEP------------- 2642
Query: 167 YGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDL 226
E + L RR + + ++E ++ E++ L Q + +
Sbjct: 2643 --------EHSFDGL---------------RRKVSAQRLQEAGILSAEELQRLAQGHTTV 2679
Query: 227 HVRSRNQVV----LSRQLSEDLLL--TREALEKEVQLRRQLQQEKEELLYRVLGANASPA 280
+R + V R LLL T E L L+RQL L+ +L A A+
Sbjct: 2680 DELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALI--LLEAQAASG 2737
Query: 281 FPLAPV 286
F L PV
Sbjct: 2738 FLLDPV 2743
Score = 29.3 bits (64), Expect = 4.3
Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 71/321 (22%)
Query: 18 RQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQQ 77
R E + + P L L A +L A EA++ D R + +E + QQ
Sbjct: 1106 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1165
Query: 78 VEKERELEL---RDRL--------------DEQQRVLEGKNEEA-------------LQV 107
ER++E+ R+R+ D +QR LE + LQ
Sbjct: 1166 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1225
Query: 108 LRASYEQ-------EKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSR-- 158
R EQ + +A+ R+ + +E I+R ++E Q K+ +I
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 159 ---NYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH---------------------- 193
YK ++ SP++ + + S + E + R H
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 194 ELDRRLILMETVKEKNLILE-EKITTLQQENEDLHVRSRNQV-----VLSRQLSEDLLLT 247
E + RL + +E+ + E E Q++ + H +++ Q L +++ E+++
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 248 REALEKEVQLRRQLQQEKEEL 268
EA Q +R +Q+E ++L
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQL 1425
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 52.8 bits (125), Expect = 4e-07
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 26/229 (11%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVL--------EGK 100
A E+A R Q+D ++ QQ EE + + + +E ER+ +L + ++ L + +
Sbjct: 2307 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2366
Query: 101 NEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNY 160
EE Q R E+ E L H A+ + + L Q + +R+ E+I
Sbjct: 2367 AEEDAQRFRKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2425
Query: 161 KKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQ 220
+K ++L+ ++++K+E + + + +L ET + L EK + LQ
Sbjct: 2426 EK-------------EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2472
Query: 221 QENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELL 269
+E + + L + +++ ++ E++ + ++Q++QE++ L+
Sbjct: 2473 RE----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517
Score = 51.6 bits (122), Expect = 8e-07
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 35/277 (12%)
Query: 17 KRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAE--------------RHQKDITR 62
+++E E +Q + E L L G+ + A+EEAE R ++ R
Sbjct: 2027 QQKEQELQQTLQQEQSVLDQLRGEAEAARR--AAEEAEEARVQAEREAAQSRRQVEEAER 2084
Query: 63 ILQQHEEEKKKWAQ------QVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEK 116
+ Q EE+ + AQ ++ KE E E R +Q L K Q A E+ K
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-----QAADAEMEKHK 2139
Query: 117 EALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQ 176
+ + R+ + +QE + L QLE + ++E + + K + E+
Sbjct: 2140 KFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLDEEL--QRLKAEATEAARQRSQVEE 2196
Query: 177 ELESLHFVIEMKNE---RIHELDRRLILMETVKEKNLILEE--KITTLQQENEDLHVRSR 231
EL S+ +E ++ RI +R LIL + + + EE K+ + +E L V ++
Sbjct: 2197 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2256
Query: 232 NQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
L + EDL R EK ++ + Q QE L
Sbjct: 2257 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Score = 43.9 bits (102), Expect = 2e-04
Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 46/294 (15%)
Query: 15 KKKRQEPEPEQPPRPEPHELG--PLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKK 72
++ +Q+ E E+ EL L + A+ ++L A E A++ +Q EE ++
Sbjct: 1580 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 73 ------KWAQQVEKERELELRDRLDEQQRVLEGKNEEALQV------LRASYEQE----- 115
K +Q ++REL L++Q+++ EG ++ L LRA EQ
Sbjct: 1640 EARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698
Query: 116 --KEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQF 173
+E L REA++ Q+ +LEA AK+ R E +L + + ++ S S+
Sbjct: 1699 LLEEELARLQREAAAATQK-----RQELEAELAKV-RAEMEVLLASKARAEEESRSTSEK 1752
Query: 174 WEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQE----------- 222
+Q LE+ E E R L E K + + EE + E
Sbjct: 1753 SKQRLEA---EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809
Query: 223 -NEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRR---QLQQEKEELLYRV 272
E +++ ++ L + +E+ L R A ++ Q RR Q Q K ++ R+
Sbjct: 1810 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863
Score = 39.3 bits (90), Expect = 0.004
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 14/217 (6%)
Query: 66 QHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFRE 125
Q E E K+ Q++++E +D QQ+ + +E LQ LR S E E +A
Sbjct: 1353 QAEREAKELQQRMQEEVVRREEAAVDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEA 1410
Query: 126 ASSTQ---QETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLH 182
A ++ +E I + QLEA + + E + + + ++ + + ++E E L
Sbjct: 1411 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA--LRARAEEAEAQKRQAQEEAERLR 1468
Query: 183 FVIEMKNERIHELDRRLILM-----ETVKEKNLILEEKITTLQQENEDLHVRSRN-QVVL 236
++ +++R + + L E +EK L + + L+ + E+ R R +V
Sbjct: 1469 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVER 1527
Query: 237 SRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVL 273
+RQ+ L + + E E+Q +R EK L R L
Sbjct: 1528 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Score = 37.4 bits (85), Expect = 0.016
Identities = 55/247 (22%), Positives = 105/247 (42%), Gaps = 31/247 (12%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQ-QVEKERELELRDRLDEQQRVLEGKNEEALQV-- 107
EE R Q++ Q+ +E + + A+ + E E L + R +E+ R K+++ L+
Sbjct: 1702 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1761
Query: 108 ------------LRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAF--------QAK 147
LRA E+ K + +A+ + E L +L A +A+
Sbjct: 1762 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1821
Query: 148 MKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH-----ELDRRLILM 202
+ E+ + ++ +D + E++ IE + ++ EL+R+ L+
Sbjct: 1822 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1881
Query: 203 ETVKEKNLILEEKITTLQQENEDLHV-RSRNQVVLSRQLS--EDLLLTREALEKEVQLRR 259
E + +EE+I L+ E ++ ++ L R S ED L ++E E E +R
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941
Query: 260 QLQQEKE 266
QL E+E
Sbjct: 1942 QLAAEEE 1948
Score = 36.6 bits (83), Expect = 0.027
Identities = 54/253 (21%), Positives = 102/253 (40%), Gaps = 31/253 (12%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVL 108
A E+A R + + R+L + + A +++ E E+ L+++ E +R+ +EA Q
Sbjct: 1788 AEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1846
Query: 109 RASYE--QEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
R + Q K + + ++R +E + ++VEE IL+ K +
Sbjct: 1847 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEK 1904
Query: 167 YGSPSQFWEQEL--------------ESLHFVIEMKNERIHELDRRLILMETVKEKNLIL 212
+ E EL E + + E +RR E +K+L
Sbjct: 1905 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1964
Query: 213 EEKITTLQQENEDLHVRSRNQVVLSRQLSE--------DLLLTREALEKEVQLRRQLQ-- 262
EE+ ++ + R + +V +R+L E L L +EA +K +Q +
Sbjct: 1965 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2024
Query: 263 --QEKEELLYRVL 273
Q+KE+ L + L
Sbjct: 2025 AVQQKEQELQQTL 2037
Score = 35.0 bits (79), Expect = 0.079
Identities = 59/244 (24%), Positives = 100/244 (40%), Gaps = 35/244 (14%)
Query: 50 SEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLR 109
S EAE K + + + E+ + V + E +R +QQ E EEA + L
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Query: 110 ASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGS 169
+ EAL + QQ+++ +Q EA + K + E +R K +
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSL----AQAEAEKQKEEAERE---ARRRGKAEEQAVR 1653
Query: 170 PSQFWEQELESLHFVIEMKNERIHELDRRLILM----ETVKEKNLILEEKITTLQQ---- 221
+ EQELE + E ++ ++ LI + E +++ +LEE++ LQ+
Sbjct: 1654 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1713
Query: 222 --------ENEDLHVRSRNQVVL---------SRQLSEDLLLTREALEKEVQLRRQLQQE 264
E E VR+ +V+L SR SE +++ LE E R+L +E
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEE 1770
Query: 265 KEEL 268
L
Sbjct: 1771 AARL 1774
Score = 35.0 bits (79), Expect = 0.079
Identities = 55/246 (22%), Positives = 95/246 (38%), Gaps = 57/246 (23%)
Query: 47 LCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQ 106
+ + EEA R Q + +++ +EE QQ+E++R +Q+ +L +N+ +
Sbjct: 2517 VASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRR--------QQEELLAEENQRLRE 2564
Query: 107 VLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
L+ EQ + AL HS E +++Q L + +A E
Sbjct: 2565 QLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEP------------- 2610
Query: 167 YGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDL 226
E + L RR + + ++E ++ E++ L Q + +
Sbjct: 2611 --------EHSFDGL---------------RRKVSAQRLQEAGILSAEELQRLAQGHTTV 2647
Query: 227 HVRSRNQVV----LSRQLSEDLLL--TREALEKEVQLRRQLQQEKEELLYRVLGANASPA 280
+R + V R LLL T E L L+RQL L+ +L A A+
Sbjct: 2648 DELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALI--LLEAQAASG 2705
Query: 281 FPLAPV 286
F L PV
Sbjct: 2706 FLLDPV 2711
Score = 29.3 bits (64), Expect = 4.3
Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 71/321 (22%)
Query: 18 RQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQQ 77
R E + + P L L A +L A EA++ D R + +E + QQ
Sbjct: 1074 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1133
Query: 78 VEKERELEL---RDRL--------------DEQQRVLEGKNEEA-------------LQV 107
ER++E+ R+R+ D +QR LE + LQ
Sbjct: 1134 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1193
Query: 108 LRASYEQ-------EKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSR-- 158
R EQ + +A+ R+ + +E I+R ++E Q K+ +I
Sbjct: 1194 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAIKDYEL 1252
Query: 159 ---NYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH---------------------- 193
YK ++ SP++ + + S + E + R H
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312
Query: 194 ELDRRLILMETVKEKNLILE-EKITTLQQENEDLHVRSRNQV-----VLSRQLSEDLLLT 247
E + RL + +E+ + E E Q++ + H +++ Q L +++ E+++
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 248 REALEKEVQLRRQLQQEKEEL 268
EA Q +R +Q+E ++L
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQL 1393
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 52.8 bits (125), Expect = 4e-07
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 26/229 (11%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVL--------EGK 100
A E+A R Q+D ++ QQ EE + + + +E ER+ +L + ++ L + +
Sbjct: 2476 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2535
Query: 101 NEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNY 160
EE Q R E+ E L H A+ + + L Q + +R+ E+I
Sbjct: 2536 AEEDAQRFRKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2594
Query: 161 KKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQ 220
+K ++L+ ++++K+E + + + +L ET + L EK + LQ
Sbjct: 2595 EK-------------EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2641
Query: 221 QENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELL 269
+E + + L + +++ ++ E++ + ++Q++QE++ L+
Sbjct: 2642 RE----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686
Score = 51.6 bits (122), Expect = 8e-07
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 35/277 (12%)
Query: 17 KRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAE--------------RHQKDITR 62
+++E E +Q + E L L G+ + A+EEAE R ++ R
Sbjct: 2196 QQKEQELQQTLQQEQSVLDQLRGEAEAARR--AAEEAEEARVQAEREAAQSRRQVEEAER 2253
Query: 63 ILQQHEEEKKKWAQ------QVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEK 116
+ Q EE+ + AQ ++ KE E E R +Q L K Q A E+ K
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-----QAADAEMEKHK 2308
Query: 117 EALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQ 176
+ + R+ + +QE + L QLE + ++E + + K + E+
Sbjct: 2309 KFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLDEEL--QRLKAEATEAARQRSQVEE 2365
Query: 177 ELESLHFVIEMKNE---RIHELDRRLILMETVKEKNLILEE--KITTLQQENEDLHVRSR 231
EL S+ +E ++ RI +R LIL + + + EE K+ + +E L V ++
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2425
Query: 232 NQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
L + EDL R EK ++ + Q QE L
Sbjct: 2426 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Score = 43.9 bits (102), Expect = 2e-04
Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 46/294 (15%)
Query: 15 KKKRQEPEPEQPPRPEPHELG--PLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKK 72
++ +Q+ E E+ EL L + A+ ++L A E A++ +Q EE ++
Sbjct: 1749 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 73 ------KWAQQVEKERELELRDRLDEQQRVLEGKNEEALQV------LRASYEQE----- 115
K +Q ++REL L++Q+++ EG ++ L LRA EQ
Sbjct: 1809 EARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867
Query: 116 --KEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQF 173
+E L REA++ Q+ +LEA AK+ R E +L + + ++ S S+
Sbjct: 1868 LLEEELARLQREAAAATQK-----RQELEAELAKV-RAEMEVLLASKARAEEESRSTSEK 1921
Query: 174 WEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQE----------- 222
+Q LE+ E E R L E K + + EE + E
Sbjct: 1922 SKQRLEA---EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978
Query: 223 -NEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRR---QLQQEKEELLYRV 272
E +++ ++ L + +E+ L R A ++ Q RR Q Q K ++ R+
Sbjct: 1979 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032
Score = 39.3 bits (90), Expect = 0.004
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 14/217 (6%)
Query: 66 QHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFRE 125
Q E E K+ Q++++E +D QQ+ + +E LQ LR S E E +A
Sbjct: 1522 QAEREAKELQQRMQEEVVRREEAAVDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEA 1579
Query: 126 ASSTQ---QETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLH 182
A ++ +E I + QLEA + + E + + + ++ + + ++E E L
Sbjct: 1580 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA--LRARAEEAEAQKRQAQEEAERLR 1637
Query: 183 FVIEMKNERIHELDRRLILM-----ETVKEKNLILEEKITTLQQENEDLHVRSRN-QVVL 236
++ +++R + + L E +EK L + + L+ + E+ R R +V
Sbjct: 1638 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVER 1696
Query: 237 SRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVL 273
+RQ+ L + + E E+Q +R EK L R L
Sbjct: 1697 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Score = 37.4 bits (85), Expect = 0.016
Identities = 55/247 (22%), Positives = 105/247 (42%), Gaps = 31/247 (12%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQ-QVEKERELELRDRLDEQQRVLEGKNEEALQV-- 107
EE R Q++ Q+ +E + + A+ + E E L + R +E+ R K+++ L+
Sbjct: 1871 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1930
Query: 108 ------------LRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAF--------QAK 147
LRA E+ K + +A+ + E L +L A +A+
Sbjct: 1931 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1990
Query: 148 MKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH-----ELDRRLILM 202
+ E+ + ++ +D + E++ IE + ++ EL+R+ L+
Sbjct: 1991 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 2050
Query: 203 ETVKEKNLILEEKITTLQQENEDLHV-RSRNQVVLSRQLS--EDLLLTREALEKEVQLRR 259
E + +EE+I L+ E ++ ++ L R S ED L ++E E E +R
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110
Query: 260 QLQQEKE 266
QL E+E
Sbjct: 2111 QLAAEEE 2117
Score = 36.6 bits (83), Expect = 0.027
Identities = 54/253 (21%), Positives = 102/253 (40%), Gaps = 31/253 (12%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVL 108
A E+A R + + R+L + + A +++ E E+ L+++ E +R+ +EA Q
Sbjct: 1957 AEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 2015
Query: 109 RASYE--QEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
R + Q K + + ++R +E + ++VEE IL+ K +
Sbjct: 2016 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEK 2073
Query: 167 YGSPSQFWEQEL--------------ESLHFVIEMKNERIHELDRRLILMETVKEKNLIL 212
+ E EL E + + E +RR E +K+L
Sbjct: 2074 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133
Query: 213 EEKITTLQQENEDLHVRSRNQVVLSRQLSE--------DLLLTREALEKEVQLRRQLQ-- 262
EE+ ++ + R + +V +R+L E L L +EA +K +Q +
Sbjct: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193
Query: 263 --QEKEELLYRVL 273
Q+KE+ L + L
Sbjct: 2194 AVQQKEQELQQTL 2206
Score = 35.0 bits (79), Expect = 0.079
Identities = 59/244 (24%), Positives = 100/244 (40%), Gaps = 35/244 (14%)
Query: 50 SEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLR 109
S EAE K + + + E+ + V + E +R +QQ E EEA + L
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Query: 110 ASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGS 169
+ EAL + QQ+++ +Q EA + K + E +R K +
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSL----AQAEAEKQKEEAERE---ARRRGKAEEQAVR 1822
Query: 170 PSQFWEQELESLHFVIEMKNERIHELDRRLILM----ETVKEKNLILEEKITTLQQ---- 221
+ EQELE + E ++ ++ LI + E +++ +LEE++ LQ+
Sbjct: 1823 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1882
Query: 222 --------ENEDLHVRSRNQVVL---------SRQLSEDLLLTREALEKEVQLRRQLQQE 264
E E VR+ +V+L SR SE +++ LE E R+L +E
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEE 1939
Query: 265 KEEL 268
L
Sbjct: 1940 AARL 1943
Score = 35.0 bits (79), Expect = 0.079
Identities = 55/246 (22%), Positives = 95/246 (38%), Gaps = 57/246 (23%)
Query: 47 LCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQ 106
+ + EEA R Q + +++ +EE QQ+E++R +Q+ +L +N+ +
Sbjct: 2686 VASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRR--------QQEELLAEENQRLRE 2733
Query: 107 VLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
L+ EQ + AL HS E +++Q L + +A E
Sbjct: 2734 QLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEP------------- 2779
Query: 167 YGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDL 226
E + L RR + + ++E ++ E++ L Q + +
Sbjct: 2780 --------EHSFDGL---------------RRKVSAQRLQEAGILSAEELQRLAQGHTTV 2816
Query: 227 HVRSRNQVV----LSRQLSEDLLL--TREALEKEVQLRRQLQQEKEELLYRVLGANASPA 280
+R + V R LLL T E L L+RQL L+ +L A A+
Sbjct: 2817 DELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALI--LLEAQAASG 2874
Query: 281 FPLAPV 286
F L PV
Sbjct: 2875 FLLDPV 2880
Score = 29.3 bits (64), Expect = 4.3
Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 71/321 (22%)
Query: 18 RQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQQ 77
R E + + P L L A +L A EA++ D R + +E + QQ
Sbjct: 1243 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1302
Query: 78 VEKERELEL---RDRL--------------DEQQRVLEGKNEEA-------------LQV 107
ER++E+ R+R+ D +QR LE + LQ
Sbjct: 1303 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1362
Query: 108 LRASYEQ-------EKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSR-- 158
R EQ + +A+ R+ + +E I+R ++E Q K+ +I
Sbjct: 1363 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAIKDYEL 1421
Query: 159 ---NYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH---------------------- 193
YK ++ SP++ + + S + E + R H
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481
Query: 194 ELDRRLILMETVKEKNLILE-EKITTLQQENEDLHVRSRNQV-----VLSRQLSEDLLLT 247
E + RL + +E+ + E E Q++ + H +++ Q L +++ E+++
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 248 REALEKEVQLRRQLQQEKEEL 268
EA Q +R +Q+E ++L
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQL 1562
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 52.8 bits (125), Expect = 4e-07
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 26/229 (11%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVL--------EGK 100
A E+A R Q+D ++ QQ EE + + + +E ER+ +L + ++ L + +
Sbjct: 2317 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR 2376
Query: 101 NEEALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNY 160
EE Q R E+ E L H A+ + + L Q + +R+ E+I
Sbjct: 2377 AEEDAQRFRKQAEEIGEKL-HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2435
Query: 161 KKHIQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQ 220
+K ++L+ ++++K+E + + + +L ET + L EK + LQ
Sbjct: 2436 EK-------------EKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQ 2482
Query: 221 QENEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELL 269
+E + + L + +++ ++ E++ + ++Q++QE++ L+
Sbjct: 2483 RE----RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
Score = 51.6 bits (122), Expect = 8e-07
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 35/277 (12%)
Query: 17 KRQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAE--------------RHQKDITR 62
+++E E +Q + E L L G+ + A+EEAE R ++ R
Sbjct: 2037 QQKEQELQQTLQQEQSVLDQLRGEAEAARR--AAEEAEEARVQAEREAAQSRRQVEEAER 2094
Query: 63 ILQQHEEEKKKWAQ------QVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEK 116
+ Q EE+ + AQ ++ KE E E R +Q L K Q A E+ K
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK-----QAADAEMEKHK 2149
Query: 117 EALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQ 176
+ + R+ + +QE + L QLE + ++E + + K + E+
Sbjct: 2150 KFAEQTLRQKAQVEQE-LTTLRLQLEETDHQKNLLDEEL--QRLKAEATEAARQRSQVEE 2206
Query: 177 ELESLHFVIEMKNE---RIHELDRRLILMETVKEKNLILEE--KITTLQQENEDLHVRSR 231
EL S+ +E ++ RI +R LIL + + + EE K+ + +E L V ++
Sbjct: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2266
Query: 232 NQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEEL 268
L + EDL R EK ++ + Q QE L
Sbjct: 2267 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Score = 43.9 bits (102), Expect = 2e-04
Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 46/294 (15%)
Query: 15 KKKRQEPEPEQPPRPEPHELG--PLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKK 72
++ +Q+ E E+ EL L + A+ ++L A E A++ +Q EE ++
Sbjct: 1590 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 73 ------KWAQQVEKERELELRDRLDEQQRVLEGKNEEALQV------LRASYEQE----- 115
K +Q ++REL L++Q+++ EG ++ L LRA EQ
Sbjct: 1650 EARRRGKAEEQAVRQREL-AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708
Query: 116 --KEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQF 173
+E L REA++ Q+ +LEA AK+ R E +L + + ++ S S+
Sbjct: 1709 LLEEELARLQREAAAATQK-----RQELEAELAKV-RAEMEVLLASKARAEEESRSTSEK 1762
Query: 174 WEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQE----------- 222
+Q LE+ E E R L E K + + EE + E
Sbjct: 1763 SKQRLEA---EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819
Query: 223 -NEDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRR---QLQQEKEELLYRV 272
E +++ ++ L + +E+ L R A ++ Q RR Q Q K ++ R+
Sbjct: 1820 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873
Score = 39.3 bits (90), Expect = 0.004
Identities = 52/217 (23%), Positives = 97/217 (44%), Gaps = 14/217 (6%)
Query: 66 QHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLRASYEQEKEALTHSFRE 125
Q E E K+ Q++++E +D QQ+ + +E LQ LR S E E +A
Sbjct: 1363 QAEREAKELQQRMQEEVVRREEAAVDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEA 1420
Query: 126 ASSTQ---QETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGSPSQFWEQELESLH 182
A ++ +E I + QLEA + + E + + + ++ + + ++E E L
Sbjct: 1421 AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA--LRARAEEAEAQKRQAQEEAERLR 1478
Query: 183 FVIEMKNERIHELDRRLILM-----ETVKEKNLILEEKITTLQQENEDLHVRSRN-QVVL 236
++ +++R + + L E +EK L + + L+ + E+ R R +V
Sbjct: 1479 RQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL-QALEELRLQAEEAERRLRQAEVER 1537
Query: 237 SRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRVL 273
+RQ+ L + + E E+Q +R EK L R L
Sbjct: 1538 ARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Score = 37.4 bits (85), Expect = 0.016
Identities = 55/247 (22%), Positives = 105/247 (42%), Gaps = 31/247 (12%)
Query: 51 EEAERHQKDITRILQQHEEEKKKWAQ-QVEKERELELRDRLDEQQRVLEGKNEEALQV-- 107
EE R Q++ Q+ +E + + A+ + E E L + R +E+ R K+++ L+
Sbjct: 1712 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1771
Query: 108 ------------LRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAF--------QAK 147
LRA E+ K + +A+ + E L +L A +A+
Sbjct: 1772 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE 1831
Query: 148 MKRVEESILSRNYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH-----ELDRRLILM 202
+ E+ + ++ +D + E++ IE + ++ EL+R+ L+
Sbjct: 1832 IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1891
Query: 203 ETVKEKNLILEEKITTLQQENEDLHV-RSRNQVVLSRQLS--EDLLLTREALEKEVQLRR 259
E + +EE+I L+ E ++ ++ L R S ED L ++E E E +R
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951
Query: 260 QLQQEKE 266
QL E+E
Sbjct: 1952 QLAAEEE 1958
Score = 36.6 bits (83), Expect = 0.027
Identities = 54/253 (21%), Positives = 102/253 (40%), Gaps = 31/253 (12%)
Query: 49 ASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVL 108
A E+A R + + R+L + + A +++ E E+ L+++ E +R+ +EA Q
Sbjct: 1798 AEEDAARQRAEAERVLAEKLAAIGE-ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1856
Query: 109 RASYE--QEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
R + Q K + + ++R +E + ++VEE IL+ K +
Sbjct: 1857 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA--LKASFEK 1914
Query: 167 YGSPSQFWEQEL--------------ESLHFVIEMKNERIHELDRRLILMETVKEKNLIL 212
+ E EL E + + E +RR E +K+L
Sbjct: 1915 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
Query: 213 EEKITTLQQENEDLHVRSRNQVVLSRQLSE--------DLLLTREALEKEVQLRRQLQ-- 262
EE+ ++ + R + +V +R+L E L L +EA +K +Q +
Sbjct: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034
Query: 263 --QEKEELLYRVL 273
Q+KE+ L + L
Sbjct: 2035 AVQQKEQELQQTL 2047
Score = 35.0 bits (79), Expect = 0.079
Identities = 59/244 (24%), Positives = 100/244 (40%), Gaps = 35/244 (14%)
Query: 50 SEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQVLR 109
S EAE K + + + E+ + V + E +R +QQ E EEA + L
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1610
Query: 110 ASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQDYGS 169
+ EAL + QQ+++ +Q EA + K + E +R K +
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSL----AQAEAEKQKEEAERE---ARRRGKAEEQAVR 1663
Query: 170 PSQFWEQELESLHFVIEMKNERIHELDRRLILM----ETVKEKNLILEEKITTLQQ---- 221
+ EQELE + E ++ ++ LI + E +++ +LEE++ LQ+
Sbjct: 1664 QRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAA 1723
Query: 222 --------ENEDLHVRSRNQVVL---------SRQLSEDLLLTREALEKEVQLRRQLQQE 264
E E VR+ +V+L SR SE +++ LE E R+L +E
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQRLEAEAGRFRELAEE 1780
Query: 265 KEEL 268
L
Sbjct: 1781 AARL 1784
Score = 35.0 bits (79), Expect = 0.079
Identities = 55/246 (22%), Positives = 95/246 (38%), Gaps = 57/246 (23%)
Query: 47 LCASEEAERHQKDITRILQQHEEEKKKWAQQVEKERELELRDRLDEQQRVLEGKNEEALQ 106
+ + EEA R Q + +++ +EE QQ+E++R +Q+ +L +N+ +
Sbjct: 2527 VASMEEARRRQHEAEEGVRRKQEE----LQQLEQQRR--------QQEELLAEENQRLRE 2574
Query: 107 VLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKHIQD 166
L+ EQ + AL HS E +++Q L + +A E
Sbjct: 2575 QLQLLEEQHRAALAHS-EEVTASQVAATKTLPNGRDALDGPAAEAEP------------- 2620
Query: 167 YGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQENEDL 226
E + L RR + + ++E ++ E++ L Q + +
Sbjct: 2621 --------EHSFDGL---------------RRKVSAQRLQEAGILSAEELQRLAQGHTTV 2657
Query: 227 HVRSRNQVV----LSRQLSEDLLL--TREALEKEVQLRRQLQQEKEELLYRVLGANASPA 280
+R + V R LLL T E L L+RQL L+ +L A A+
Sbjct: 2658 DELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALI--LLEAQAASG 2715
Query: 281 FPLAPV 286
F L PV
Sbjct: 2716 FLLDPV 2721
Score = 29.3 bits (64), Expect = 4.3
Identities = 65/321 (20%), Positives = 121/321 (37%), Gaps = 71/321 (22%)
Query: 18 RQEPEPEQPPRPEPHELGPLNGDTAITVQLCASEEAERHQKDITRILQQHEEEKKKWAQQ 77
R E + + P L L A +L A EA++ D R + +E + QQ
Sbjct: 1084 RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQ 1143
Query: 78 VEKERELEL---RDRL--------------DEQQRVLEGKNEEA-------------LQV 107
ER++E+ R+R+ D +QR LE + LQ
Sbjct: 1144 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1203
Query: 108 LRASYEQ-------EKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSR-- 158
R EQ + +A+ R+ + +E I+R ++E Q K+ +I
Sbjct: 1204 ARRRQEQIQAMPLADSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYINAIKDYEL 1262
Query: 159 ---NYKKHIQDYGSPSQFWEQELESLHFVIEMKNERIH---------------------- 193
YK ++ SP++ + + S + E + R H
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322
Query: 194 ELDRRLILMETVKEKNLILE-EKITTLQQENEDLHVRSRNQV-----VLSRQLSEDLLLT 247
E + RL + +E+ + E E Q++ + H +++ Q L +++ E+++
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 248 REALEKEVQLRRQLQQEKEEL 268
EA Q +R +Q+E ++L
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQL 1403
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,144,746
Number of Sequences: 37866
Number of extensions: 612437
Number of successful extensions: 9743
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 305
Number of HSP's successfully gapped in prelim test: 921
Number of HSP's that attempted gapping in prelim test: 5410
Number of HSP's gapped (non-prelim): 3504
length of query: 296
length of database: 18,247,518
effective HSP length: 102
effective length of query: 194
effective length of database: 14,385,186
effective search space: 2790726084
effective search space used: 2790726084
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.