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Search of human proteins with 4585712
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4585712 neurotrophic tyrosine kinase, receptor, type 1
isoform 2 [Homo sapiens]
(796 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 1635 0.0
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 1617 0.0
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 1465 0.0
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 746 0.0
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 736 0.0
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 719 0.0
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 709 0.0
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 285 9e-77
gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isofo... 278 2e-74
gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isofo... 257 3e-68
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 251 2e-66
gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isofo... 247 3e-65
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 244 3e-64
gi|62420886 discoidin domain receptor family, member 2 precursor... 244 3e-64
gi|62420884 discoidin domain receptor family, member 2 precursor... 244 3e-64
gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec... 238 2e-62
gi|38327632 discoidin domain receptor family, member 1 isoform b... 238 2e-62
gi|83977450 discoidin domain receptor family, member 1 isoform a... 238 2e-62
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 237 3e-62
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 237 4e-62
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 237 4e-62
gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isofo... 234 2e-61
gi|83977452 discoidin domain receptor family, member 1 isoform c... 231 2e-60
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 230 3e-60
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 224 2e-58
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 224 2e-58
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 223 4e-58
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 222 1e-57
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 222 1e-57
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 222 1e-57
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 1635 bits (4234), Expect = 0.0
Identities = 796/796 (100%), Positives = 796/796 (100%)
Query: 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH 60
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
Sbjct: 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH 60
Query: 61 HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 120
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
Sbjct: 61 HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 120
Query: 121 NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ 180
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
Sbjct: 121 NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ 180
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK 240
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK 240
Query: 241 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC 300
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
Sbjct: 241 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC 300
Query: 301 IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT 360
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
Sbjct: 301 IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT 360
Query: 361 LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV 420
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
Sbjct: 361 LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV 420
Query: 421 AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE 480
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
Sbjct: 421 AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE 480
Query: 481 GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML 540
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
Sbjct: 481 GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML 540
Query: 541 VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF 600
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
Sbjct: 541 VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF 600
Query: 601 LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 660
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
Sbjct: 601 LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 660
Query: 661 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 720
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
Sbjct: 661 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 720
Query: 721 FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR 780
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
Sbjct: 721 FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR 780
Query: 781 LQALAQAPPVYLDVLG 796
LQALAQAPPVYLDVLG
Sbjct: 781 LQALAQAPPVYLDVLG 796
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
1 [Homo sapiens]
Length = 790
Score = 1617 bits (4188), Expect = 0.0
Identities = 790/796 (99%), Positives = 790/796 (99%), Gaps = 6/796 (0%)
Query: 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH 60
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
Sbjct: 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH 60
Query: 61 HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 120
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
Sbjct: 61 HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL 120
Query: 121 NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ 180
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
Sbjct: 121 NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ 180
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK 240
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
Sbjct: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK 240
Query: 241 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC 300
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
Sbjct: 241 SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC 300
Query: 301 IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT 360
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
Sbjct: 301 IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT 360
Query: 361 LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV 420
LLAANPFGQASASIMAAFMDNPFEFNPEDPIP DTNSTSGDPVEKKDETPFGVSV
Sbjct: 361 LLAANPFGQASASIMAAFMDNPFEFNPEDPIP------DTNSTSGDPVEKKDETPFGVSV 414
Query: 421 AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE 480
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
Sbjct: 415 AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE 474
Query: 481 GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML 540
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
Sbjct: 475 GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML 534
Query: 541 VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF 600
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
Sbjct: 535 VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF 594
Query: 601 LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 660
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
Sbjct: 595 LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 654
Query: 661 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 720
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
Sbjct: 655 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 714
Query: 721 FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR 780
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
Sbjct: 715 FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR 774
Query: 781 LQALAQAPPVYLDVLG 796
LQALAQAPPVYLDVLG
Sbjct: 775 LQALAQAPPVYLDVLG 790
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
3 [Homo sapiens]
Length = 760
Score = 1465 bits (3792), Expect = 0.0
Identities = 720/729 (98%), Positives = 720/729 (98%), Gaps = 6/729 (0%)
Query: 68 LTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 127
L YIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL
Sbjct: 38 LAASYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 97
Query: 128 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP 187
ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP
Sbjct: 98 ESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMP 157
Query: 188 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 247
NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL
Sbjct: 158 NASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL 217
Query: 248 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG 307
GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG
Sbjct: 218 GLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDG 277
Query: 308 QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF 367
QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF
Sbjct: 278 QPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPF 337
Query: 368 GQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVF 427
GQASASIMAAFMDNPFEFNPEDPIP DTNSTSGDPVEKKDETPFGVSVAVGLAVF
Sbjct: 338 GQASASIMAAFMDNPFEFNPEDPIP------DTNSTSGDPVEKKDETPFGVSVAVGLAVF 391
Query: 428 ACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 487
ACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ
Sbjct: 392 ACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQ 451
Query: 488 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 547
GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK
Sbjct: 452 GHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511
Query: 548 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPD 607
EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPD
Sbjct: 512 EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPD 571
Query: 608 AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIG 667
AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIG
Sbjct: 572 AKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIG 631
Query: 668 DFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP 727
DFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP
Sbjct: 632 DFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQP 691
Query: 728 WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQA 787
WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQA
Sbjct: 692 WYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQA 751
Query: 788 PPVYLDVLG 796
PPVYLDVLG
Sbjct: 752 PPVYLDVLG 760
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 746 bits (1925), Expect = 0.0
Identities = 402/766 (52%), Positives = 503/766 (65%), Gaps = 51/766 (6%)
Query: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
Query: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
Query: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
Query: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNN 373
Query: 357 GNYTLLAANPFGQASASIMAAFMDNPF-----------EFNPEDPIPVSFSPVDTNSTSG 405
GNYTL+A NP G A+ +I F+ PF E +P PI V+ P
Sbjct: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKP-------- 425
Query: 406 DPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAM 464
+E FGVS+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A
Sbjct: 426 ------EEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSAS 479
Query: 465 SLHFMTLGGSSLSPTE-GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIV 511
LH + G ++ S + G + + G +IENPQYF D V HIKRRDIV
Sbjct: 480 PLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIV 539
Query: 512 LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH 571
LK ELGEGAFGKVFLAEC+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+H
Sbjct: 540 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEH 599
Query: 572 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAV 630
IV+F+GVC +G PL+MVFEYM+HGDLN+FLR+HGPDA +L G+ A G LGL Q+L +
Sbjct: 600 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 659
Query: 631 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 690
ASQ+A+GMVYLA HFVHRDLATRNCLVG L+VKIGDFGMSRD+YSTDYYRVGG TMLP
Sbjct: 660 ASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLP 719
Query: 691 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 750
IRWMPPESI+YRKFTTESDVWSFGV+LWEIFTYGKQPW+QLSNTE I+CITQGR LERPR
Sbjct: 720 IRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPR 779
Query: 751 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 796
CP EVY +M GCWQREPQQR +IK+++ L AL +A P+YLD+LG
Sbjct: 780 VCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 825
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
a precursor [Homo sapiens]
Length = 839
Score = 736 bits (1900), Expect = 0.0
Identities = 402/780 (51%), Positives = 503/780 (64%), Gaps = 65/780 (8%)
Query: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
Query: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
Query: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
Query: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGE---ISEGCLLFNKPTHYNN 373
Query: 357 GNYTLLAANPFGQASASIMAAFMDNPF-----------EFNPEDPIPVSFSPVDTNSTSG 405
GNYTL+A NP G A+ +I F+ PF E +P PI V+ P
Sbjct: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKP-------- 425
Query: 406 DPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAM 464
+E FGVS+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A
Sbjct: 426 ------EEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSAS 479
Query: 465 SLHFMTLGGSSLSPTE-GKGSGLQGH----IIENPQYFS--------DACVHHIKRRDIV 511
LH + G ++ S + G + + G +IENPQYF D V HIKRRDIV
Sbjct: 480 PLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIV 539
Query: 512 LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQH 571
LK ELGEGAFGKVFLAEC+NL P +DKMLVAVKALK+ + +AR+DFQREAELLT LQH+H
Sbjct: 540 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEH 599
Query: 572 IVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAV 630
IV+F+GVC +G PL+MVFEYM+HGDLN+FLR+HGPDA +L G+ A G LGL Q+L +
Sbjct: 600 IVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHI 659
Query: 631 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYR-------- 682
ASQ+A+GMVYLA HFVHRDLATRNCLVG L+VKIGDFGMSRD+YSTDYYR
Sbjct: 660 ASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGND 719
Query: 683 ------VGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 736
VGG TMLPIRWMPPESI+YRKFTTESDVWSFGV+LWEIFTYGKQPW+QLSNTE
Sbjct: 720 FCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEV 779
Query: 737 IDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 796
I+CITQGR LERPR CP EVY +M GCWQREPQQR +IK+++ L AL +A P+YLD+LG
Sbjct: 780 IECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 839
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
c precursor [Homo sapiens]
Length = 822
Score = 719 bits (1855), Expect = 0.0
Identities = 404/827 (48%), Positives = 518/827 (62%), Gaps = 53/827 (6%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFMDNPF---EFNPEDPIPVSFSPVDTNSTSGDPVEKKDET 414
+YTL+A N +G+ I A FM P NP P + + GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 415 PF-GVSVAVG---LAVFACLFLSTL-------LLVLNKCGRRNKFGINRPA-VLAPEDGL 462
P V+ G L+V+A + ++++ +L L K R +KFG+ PA V++ +D
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDS 477
Query: 463 AMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--------DACVHHIKRRD 509
A LH ++ G ++ S +EG + + +IENPQYF D V HIKR +
Sbjct: 478 ASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHN 537
Query: 510 IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQH 569
IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++AR+DF REAELLT LQH
Sbjct: 538 IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQH 597
Query: 570 QHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLA 629
+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A G P L Q+L
Sbjct: 598 EHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP--PTELTQSQMLH 655
Query: 630 VASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML 689
+A Q+AAGMVYLA HFVHRDLATRNCLVG+ L+VKIGDFGMSRD+YSTDYYRVGG TML
Sbjct: 656 IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTML 715
Query: 690 PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERP 749
PIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN E I+CITQGR L+RP
Sbjct: 716 PIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRP 775
Query: 750 RACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 796
R CP EVY +M GCWQREP R +IK +H LQ LA+A PVYLD+LG
Sbjct: 776 RTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 822
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
a precursor [Homo sapiens]
Length = 838
Score = 709 bits (1830), Expect = 0.0
Identities = 402/843 (47%), Positives = 517/843 (61%), Gaps = 69/843 (8%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQE-AKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFMDNPF---EFNPEDPIPVSFSPVDTNSTSGDPVEKKDET 414
+YTL+A N +G+ I A FM P NP P + + GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 415 PF-GVSVAVG---LAVFACLFLSTL-------LLVLNKCGRRNKFG-------------- 449
P V+ G L+V+A + ++++ +L L K R +KFG
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKS 477
Query: 450 ---INRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYFS--- 498
+ +V++ +D A LH ++ G ++ S +EG + + +IENPQYF
Sbjct: 478 RQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITN 537
Query: 499 -----DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA 553
D V HIKR +IVLK ELGEGAFGKVFLAEC+NL PEQDK+LVAVK LK+AS++A
Sbjct: 538 SQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA 597
Query: 554 RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAG 613
R+DF REAELLT LQH+HIV+F+GVC EG PL+MVFEYM+HGDLN+FLR+HGPDA L+A
Sbjct: 598 RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAE 657
Query: 614 GEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSR 673
G P L Q+L +A Q+AAGMVYLA HFVHRDLATRNCLVG+ L+VKIGDFGMSR
Sbjct: 658 GNP--PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 715
Query: 674 DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN 733
D+YSTDYYRVGG TMLPIRWMPPESI+YRKFTTESDVWS GVVLWEIFTYGKQPWYQLSN
Sbjct: 716 DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSN 775
Query: 734 TEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLD 793
E I+CITQGR L+RPR CP EVY +M GCWQREP R +IK +H LQ LA+A PVYLD
Sbjct: 776 NEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLD 835
Query: 794 VLG 796
+LG
Sbjct: 836 ILG 838
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 285 bits (730), Expect = 9e-77
Identities = 143/290 (49%), Positives = 186/290 (64%), Gaps = 10/290 (3%)
Query: 507 RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQREAELLT 565
R +I ++GEGAFG+VF A LLP + +VAVK LKE AS + DFQREA L+
Sbjct: 572 RNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMA 631
Query: 566 MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP---------DAKLLAGGED 616
+ +IV+ GVC G+P+ ++FEYM +GDLN FLRS P D + A
Sbjct: 632 EFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSS 691
Query: 617 VAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIY 676
P PL + L +A QVAAGM YL+ FVHRDLATRNCLVG+ +VVKI DFG+SR+IY
Sbjct: 692 PGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIY 751
Query: 677 STDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 736
S DYY+ +PIRWMPPESI Y ++TTESDVW++GVVLWEIF+YG QP+Y +++ E
Sbjct: 752 SADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEV 811
Query: 737 IDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQ 786
I + G L P CP E+Y +MR CW + P R S +H L+ + +
Sbjct: 812 IYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCE 861
Score = 35.0 bits (79), Expect = 0.27
Identities = 49/193 (25%), Positives = 80/193 (41%), Gaps = 33/193 (17%)
Query: 198 VQVPNASVD--VGDDVLLRCQVEGRGLEQAGW----ILTEL-EQSATVMKSGGLPSLGLT 250
+ P +VD V + C VE + W IL +L + ++ ++G L LT
Sbjct: 30 ITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQL----LT 85
Query: 251 LANVTSDLNRKNVTCWAENDVGRAEVS---VQVNVSF-----PASVQLHTAVEMHHWCIP 302
+ +V D + C A N VG A S +QV + P +V++ +E +P
Sbjct: 86 ILSV-EDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKI---IEGLKAVLP 141
Query: 303 FSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLL 362
+ G P PS+ W+ S L E S I + G LR++ + G Y +
Sbjct: 142 CTTMGNPKPSVSWIKGDSPLRENSRI----------AVLESGSLRIHNVQKEDAGQYRCV 191
Query: 363 AANPFGQASASIM 375
A N G A + ++
Sbjct: 192 AKNSLGTAYSKVV 204
Score = 33.9 bits (76), Expect = 0.61
Identities = 43/201 (21%), Positives = 80/201 (39%), Gaps = 26/201 (12%)
Query: 190 SCGVPTLKVQVP------NASVDVGDDVLLRCQVEGRGLEQAGWILTE--LEQSATVMKS 241
SCG +K++ N + G +L C G WI + L +++ +
Sbjct: 111 SCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAV- 169
Query: 242 GGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA-----EVSVQVNVSFPASVQLHTAVEM 296
L S L + NV + + C A+N +G A ++ V+V + + H
Sbjct: 170 --LESGSLRIHNVQKE-DAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFG 226
Query: 297 HHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
+ + G P P++ W+ NG+ ++ S ++ + + V L+L
Sbjct: 227 SFVTLHCTATGIPVPTITWIENGNAVSSGS------IQESVKDRVIDSRLQL---FITKP 277
Query: 357 GNYTLLAANPFGQASASIMAA 377
G YT +A N G+ ++ AA
Sbjct: 278 GLYTCIATNKHGEKFSTAKAA 298
>gi|55956794 neurotrophic tyrosine kinase, receptor, type 3 isoform
c precursor [Homo sapiens]
Length = 612
Score = 278 bits (710), Expect = 2e-74
Identities = 175/458 (38%), Positives = 242/458 (52%), Gaps = 42/458 (9%)
Query: 65 AENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSF 124
+ N+T ++IEN + L L D+ L+ LTI SGLR + P AF P L +NLS
Sbjct: 77 SRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSS 136
Query: 125 NALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQC----HGQ 180
N L +LSW+ Q LSL+EL L N +CSC +RW+Q W+E+G + Q L C Q
Sbjct: 137 NRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQ 196
Query: 181 GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQ---SAT 237
PL M + C +P + V N +V GD+ ++ C G L WI+T L+ T
Sbjct: 197 LPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQT 256
Query: 238 VMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMH 297
+ + ++ LTL NVTS+ N +TC AEN VG + SV + V +P V E+
Sbjct: 257 NLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELR 316
Query: 298 -HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNN 356
CI F V G P P+L WL NG L E+ I E+ + + GCL N+PTH NN
Sbjct: 317 LEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEG---EISEGCLLFNKPTHYNN 373
Query: 357 GNYTLLAANPFGQASASIMAAFMDNPF-----------EFNPEDPIPVSFSPVDTNSTSG 405
GNYTL+A NP G A+ +I F+ PF E +P PI V+ P
Sbjct: 374 GNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKP-------- 425
Query: 406 DPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRP-AVLAPEDGLAM 464
+E FGVS+AVGLA FAC+ L L +++NK GRR+KFG+ P AV++ E+ A
Sbjct: 426 ------EEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSAS 479
Query: 465 SLHFMTLGGSSLSPTE-GKGSGLQG----HIIENPQYF 497
LH + G ++ S + G + + G +IENPQYF
Sbjct: 480 PLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYF 517
>gi|65506779 neurotrophic tyrosine kinase, receptor, type 2 isoform
e precursor [Homo sapiens]
Length = 537
Score = 257 bits (656), Expect = 3e-68
Identities = 179/520 (34%), Positives = 264/520 (50%), Gaps = 43/520 (8%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFMDNP---FEFNPEDPIPVSFSPVDTNSTSGDPVEKKDET 414
+YTL+A N +G+ I A FM P NP P + + GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 415 P-FGVSVAVG---LAVFACLFLST-------LLLVLNKCGRRNKFGINRPA-VLAPEDGL 462
P V+ G L+V+A + +++ ++L L K R +KFG+ PA V++ +D
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDS 477
Query: 463 AMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYF 497
A LH ++ G ++ S +EG + + +IENPQYF
Sbjct: 478 ASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYF 517
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 251 bits (641), Expect = 2e-66
Identities = 128/273 (46%), Positives = 177/273 (64%), Gaps = 6/273 (2%)
Query: 515 ELGEGAFGKVFLAECHNLLPEQDK-MLVAVKALKEASESAR-QDFQREAELLTMLQHQHI 572
ELGE AFGK++ H LP D LVA+K LK+ + + +FQ+EA L+ L H +I
Sbjct: 478 ELGECAFGKIYKG--HLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNI 535
Query: 573 VRFFGVCTEGRPLLMVFEYMRHGDLNRFL--RSHGPDAKLLAGGEDVAPGPLGLGQLLAV 630
V G T+ +P+ M+FEY+ GDL+ FL RS D + + L G L +
Sbjct: 536 VCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHI 595
Query: 631 ASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLP 690
A Q+AAGM YL+ FVH+DLA RN L+G+ L VKI D G+SR+IYS DYYRV +++LP
Sbjct: 596 AIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLP 655
Query: 691 IRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPR 750
IRWMPPE+I+Y KF+++SD+WSFGVVLWEIF++G QP+Y SN E I+ + + + L
Sbjct: 656 IRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSE 715
Query: 751 ACPPEVYAIMRGCWQREPQQRHSIKDVHARLQA 783
CPP +Y++M CW P +R KD+H RL++
Sbjct: 716 DCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRS 748
>gi|65506769 neurotrophic tyrosine kinase, receptor, type 2 isoform
d precursor [Homo sapiens]
Length = 553
Score = 247 bits (631), Expect = 3e-65
Identities = 177/536 (33%), Positives = 263/536 (49%), Gaps = 59/536 (11%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFMDNP---FEFNPEDPIPVSFSPVDTNSTSGDPVEKKDET 414
+YTL+A N +G+ I A FM P NP P + + GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 415 P-FGVSVAVG---LAVFACLFLST-------LLLVLNKCGRRNKF--------------- 448
P V+ G L+V+A + +++ ++L L K R +KF
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKS 477
Query: 449 --GINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGL-----QGHIIENPQYF 497
G+ +V++ +D A LH ++ G ++ S +EG + + +IENPQYF
Sbjct: 478 RQGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYF 533
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 244 bits (622), Expect = 3e-64
Identities = 124/291 (42%), Positives = 178/291 (61%), Gaps = 11/291 (3%)
Query: 493 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 547
NP+YFS A V+ + R I + ELG+G+FG V+ ++ ++ + VA+K +
Sbjct: 977 NPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN 1036
Query: 548 EA-SESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 606
EA S R +F EA ++ H+VR GV ++G+P L++ E M GDL +LRS P
Sbjct: 1037 EAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP 1096
Query: 607 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 666
+ + + P L +++ +A ++A GM YL FVHRDLA RNC+V + VKI
Sbjct: 1097 EME-----NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKI 1151
Query: 667 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 726
GDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 1152 GDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQ 1211
Query: 727 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 777
P+ LSN + + + +G L++P CP ++ +MR CWQ P+ R S ++
Sbjct: 1212 PYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
>gi|62420886 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 244 bits (622), Expect = 3e-64
Identities = 135/303 (44%), Positives = 188/303 (62%), Gaps = 25/303 (8%)
Query: 499 DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK-----------MLVAVKALK 547
D V R+ + K +LGEG FG+V L E + +DK +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611
Query: 548 -EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 606
+A+++AR DF +E ++++ L+ +I+ VC PL M+ EYM +GDLN+FL H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671
Query: 607 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 666
+ DV + L +A+Q+A+GM YL+ L+FVHRDLATRNCLVG+ +KI
Sbjct: 672 PN---SSSSDVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKI 726
Query: 667 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GK 725
DFGMSR++YS DYYR+ GR +LPIRWM ESIL KFTT SDVW+FGV LWE FT+ +
Sbjct: 727 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQE 786
Query: 726 QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 778
QP+ QLS+ + I+ QGR+ L +P CP VY +M CW+R+ + R S +++H
Sbjct: 787 QPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846
Query: 779 ARL 781
L
Sbjct: 847 LLL 849
>gi|62420884 discoidin domain receptor family, member 2 precursor
[Homo sapiens]
Length = 855
Score = 244 bits (622), Expect = 3e-64
Identities = 135/303 (44%), Positives = 188/303 (62%), Gaps = 25/303 (8%)
Query: 499 DACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK-----------MLVAVKALK 547
D V R+ + K +LGEG FG+V L E + +DK +LVAVK L+
Sbjct: 552 DVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR 611
Query: 548 -EASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 606
+A+++AR DF +E ++++ L+ +I+ VC PL M+ EYM +GDLN+FL H P
Sbjct: 612 ADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEP 671
Query: 607 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 666
+ DV + L +A+Q+A+GM YL+ L+FVHRDLATRNCLVG+ +KI
Sbjct: 672 PN---SSSSDVRT--VSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKI 726
Query: 667 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTY-GK 725
DFGMSR++YS DYYR+ GR +LPIRWM ESIL KFTT SDVW+FGV LWE FT+ +
Sbjct: 727 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQE 786
Query: 726 QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 778
QP+ QLS+ + I+ QGR+ L +P CP VY +M CW+R+ + R S +++H
Sbjct: 787 QPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIH 846
Query: 779 ARL 781
L
Sbjct: 847 LLL 849
>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
precursor [Homo sapiens]
Length = 943
Score = 238 bits (607), Expect = 2e-62
Identities = 119/271 (43%), Positives = 169/271 (62%), Gaps = 2/271 (0%)
Query: 515 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA-RQDFQREAELLTMLQHQHIV 573
ELGE FGKV+ P + VA+K LK+ +E R++F+ EA L LQH ++V
Sbjct: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537
Query: 574 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVAS 632
GV T+ +PL M+F Y HGDL+ FL P + + + +D L + + +
Sbjct: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
Query: 633 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 692
Q+AAGM YL+ H VH+DLATRN LV L VKI D G+ R++Y+ DYY++ G ++LPIR
Sbjct: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657
Query: 693 WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC 752
WM PE+I+Y KF+ +SD+WS+GVVLWE+F+YG QP+ SN + ++ I + L P C
Sbjct: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717
Query: 753 PPEVYAIMRGCWQREPQQRHSIKDVHARLQA 783
P VYA+M CW P +R KD+H+RL+A
Sbjct: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLRA 748
>gi|38327632 discoidin domain receptor family, member 1 isoform b
[Homo sapiens]
Length = 876
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 185/296 (62%), Gaps = 24/296 (8%)
Query: 507 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESAR 554
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++AR
Sbjct: 570 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 629
Query: 555 QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 614
DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H + K G
Sbjct: 630 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 689
Query: 615 E---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG 670
A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +KI DFG
Sbjct: 690 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 749
Query: 671 MSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWY 729
MSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+ + QP+
Sbjct: 750 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 809
Query: 730 QLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 778
QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR +H
Sbjct: 810 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865
>gi|83977450 discoidin domain receptor family, member 1 isoform a
[Homo sapiens]
Length = 913
Score = 238 bits (606), Expect = 2e-62
Identities = 134/296 (45%), Positives = 185/296 (62%), Gaps = 24/296 (8%)
Query: 507 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESAR 554
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++AR
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAR 666
Query: 555 QDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGG 614
DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H + K G
Sbjct: 667 NDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGA 726
Query: 615 E---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFG 670
A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +KI DFG
Sbjct: 727 PGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFG 786
Query: 671 MSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK-QPWY 729
MSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+ + QP+
Sbjct: 787 MSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFG 846
Query: 730 QLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKDVH 778
QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR +H
Sbjct: 847 QLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 902
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 237 bits (605), Expect = 3e-62
Identities = 127/296 (42%), Positives = 177/296 (59%), Gaps = 11/296 (3%)
Query: 493 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 547
NP+YFS + ++ + R I + ELG+G+FG V+ L ++ VA+K +
Sbjct: 957 NPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN 1016
Query: 548 E-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 606
E AS +F +EA ++ + H+VR GV ++G+P L++ E M GDL LRS P
Sbjct: 1017 ELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP 1076
Query: 607 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 666
+A+ G P P LG+++ +A ++A GM YLA FVHRDLA RNC+V Q VKI
Sbjct: 1077 EAENNPG----LPQP-ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKI 1131
Query: 667 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 726
GDFGM+RD+Y TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 1132 GDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQ 1191
Query: 727 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 782
P+ LSN + + + G LE CP ++ +M CWQ P+ R S + +Q
Sbjct: 1192 PYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ 1247
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 237 bits (604), Expect = 4e-62
Identities = 126/296 (42%), Positives = 176/296 (59%), Gaps = 16/296 (5%)
Query: 493 NPQYFSDACVH----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA 542
NP+Y S + V + R I L ELG+G+FG V+ +++ + + VA
Sbjct: 984 NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 1043
Query: 543 VKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 601
VK + E AS R +F EA ++ H+VR GV ++G+P L+V E M HGDL +L
Sbjct: 1044 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 1103
Query: 602 RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 661
RS P+A+ G P L +++ +A+++A GM YL FVHRDLA RNC+V
Sbjct: 1104 RSLRPEAENNPGRP-----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1158
Query: 662 LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIF 721
VKIGDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SD+WSFGVVLWEI
Sbjct: 1159 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1218
Query: 722 TYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 777
+ +QP+ LSN + + + G L++P CP V +MR CWQ P+ R + ++
Sbjct: 1219 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1274
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 237 bits (604), Expect = 4e-62
Identities = 126/296 (42%), Positives = 176/296 (59%), Gaps = 16/296 (5%)
Query: 493 NPQYFSDACVH----------HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVA 542
NP+Y S + V + R I L ELG+G+FG V+ +++ + + VA
Sbjct: 996 NPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVA 1055
Query: 543 VKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 601
VK + E AS R +F EA ++ H+VR GV ++G+P L+V E M HGDL +L
Sbjct: 1056 VKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYL 1115
Query: 602 RSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG 661
RS P+A+ G P L +++ +A+++A GM YL FVHRDLA RNC+V
Sbjct: 1116 RSLRPEAENNPGRP-----PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHD 1170
Query: 662 LVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIF 721
VKIGDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SD+WSFGVVLWEI
Sbjct: 1171 FTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEIT 1230
Query: 722 TYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 777
+ +QP+ LSN + + + G L++P CP V +MR CWQ P+ R + ++
Sbjct: 1231 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEI 1286
>gi|55956790 neurotrophic tyrosine kinase, receptor, type 2 isoform
b precursor [Homo sapiens]
Length = 477
Score = 234 bits (598), Expect = 2e-61
Identities = 161/467 (34%), Positives = 235/467 (50%), Gaps = 37/467 (7%)
Query: 12 WHSWAAGPGSLLAWLILASAGAA-PCPDAC--------CPHGSSGLRCTRDGALDSLHHL 62
WH A WL++ AA CP +C C S G+ +S+
Sbjct: 7 WHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVD-- 64
Query: 63 PGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNL 122
EN+TE++I NQ+ L+ + D+ LRNLTIV SGL+FVA AF L +N
Sbjct: 65 --PENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINF 122
Query: 123 SFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQG- 181
+ N L SLS K + L L EL+L GNP CSC + W++ +E Q L C +
Sbjct: 123 TRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTL-QEAKSSPDTQDLYCLNESS 181
Query: 182 ---PLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATV 238
PLA++ +CG+P+ + PN +V+ G + L C V G + W + L
Sbjct: 182 KNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMN 241
Query: 239 MKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-PASVQLHTAVEMH 297
S SL +T N++SD + K ++C AEN VG + SV + V F P L + H
Sbjct: 242 ETSHTQGSLRIT--NISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDH 299
Query: 298 HWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNG 357
HWCIPF+V G P P+L+W +NG++LNE+ +I T+ N T HGCL+L+ PTH+NNG
Sbjct: 300 HWCIPFTVKGNPKPALQWFYNGAILNESKYICTKI--HVTNHTEYHGCLQLDNPTHMNNG 357
Query: 358 NYTLLAANPFGQASASIMAAFMDNP---FEFNPEDPIPVSFSPVDTNSTSGDPVEKKDET 414
+YTL+A N +G+ I A FM P NP P + + GD + +E
Sbjct: 358 DYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEI 417
Query: 415 P-FGVSVAVG---LAVFACLFLST-------LLLVLNKCGRRNKFGI 450
P V+ G L+V+A + +++ ++L L K R +KFG+
Sbjct: 418 PSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGM 464
>gi|83977452 discoidin domain receptor family, member 1 isoform c
[Homo sapiens]
Length = 919
Score = 231 bits (589), Expect = 2e-60
Identities = 134/302 (44%), Positives = 185/302 (61%), Gaps = 30/302 (9%)
Query: 507 RRDIVLKWELGEGAFGKVFLAECHNL-----------LPEQDKMLVAVKALK-EASESA- 553
R + K +LGEG FG+V L E + + + +LVAVK L+ +A+++A
Sbjct: 607 RSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNAS 666
Query: 554 -----RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDA 608
R DF +E ++++ L+ +I+R GVC + PL M+ +YM +GDLN+FL +H +
Sbjct: 667 FSLFSRNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED 726
Query: 609 KLLAGGE---DVAPGP-LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVV 664
K G A GP + LL VA+Q+A+GM YLA L+FVHRDLATRNCLVG+ +
Sbjct: 727 KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI 786
Query: 665 KIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYG 724
KI DFGMSR++Y+ DYYRV GR +LPIRWM E IL KFTT SDVW+FGV LWE+
Sbjct: 787 KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC 846
Query: 725 K-QPWYQLSNTEAIDCI-----TQGRE--LERPRACPPEVYAIMRGCWQREPQQRHSIKD 776
+ QP+ QL++ + I+ QGR+ L RP ACP +Y +M CW RE +QR
Sbjct: 847 RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ 906
Query: 777 VH 778
+H
Sbjct: 907 LH 908
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 230 bits (587), Expect = 3e-60
Identities = 122/290 (42%), Positives = 166/290 (57%), Gaps = 12/290 (4%)
Query: 505 IKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEA-SESARQDFQREAEL 563
+ R++I L LG GAFG+V+ + + + + VAVK L E SE DF EA +
Sbjct: 1111 VPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALI 1170
Query: 564 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 623
++ HQ+IVR GV + P ++ E M GDL FLR P P L
Sbjct: 1171 ISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPS--------QPSSLA 1222
Query: 624 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYSTDY 680
+ LL VA +A G YL HF+HRD+A RNCL+ G G V KIGDFGM+RDIY Y
Sbjct: 1223 MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASY 1282
Query: 681 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCI 740
YR GG MLP++WMPPE+ + FT+++D WSFGV+LWEIF+ G P+ SN E ++ +
Sbjct: 1283 YRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFV 1342
Query: 741 TQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPV 790
T G ++ P+ CP VY IM CWQ +P+ R + + R++ Q P V
Sbjct: 1343 TSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDV 1392
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 224 bits (572), Expect = 2e-58
Identities = 123/298 (41%), Positives = 165/298 (55%), Gaps = 12/298 (4%)
Query: 502 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 560
V + ++ L LG GAFG+V+ L + + VA+K L E S DF E
Sbjct: 502 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 561
Query: 561 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 620
A +++ +HQ+IVR G+ P L++ E M GD+ FLR P P
Sbjct: 562 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--------QPS 613
Query: 621 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 677
PL + LL +A +A G YL HF+HRD+A RNCL+ G V KIGDFGM+RDIY
Sbjct: 614 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 673
Query: 678 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI 737
YYR G R +LP++WMPPE+ L FT+++D WSFGV+LWEIF+ G P+ +N E +
Sbjct: 674 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 733
Query: 738 DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL 795
D + G ++ PR CP VY IM CWQ EP+ R S + RLQ Q P V +L
Sbjct: 734 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLL 791
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 224 bits (572), Expect = 2e-58
Identities = 123/298 (41%), Positives = 165/298 (55%), Gaps = 12/298 (4%)
Query: 502 VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKE-ASESARQDFQRE 560
V + ++ L LG GAFG+V+ L + + VA+K L E S DF E
Sbjct: 441 VTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLME 500
Query: 561 AELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPG 620
A +++ +HQ+IVR G+ P L++ E M GD+ FLR P P
Sbjct: 501 ALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLG--------QPS 552
Query: 621 PLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLV---GQGLVVKIGDFGMSRDIYS 677
PL + LL +A +A G YL HF+HRD+A RNCL+ G V KIGDFGM+RDIY
Sbjct: 553 PLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYR 612
Query: 678 TDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAI 737
YYR G R +LP++WMPPE+ L FT+++D WSFGV+LWEIF+ G P+ +N E +
Sbjct: 613 ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVL 672
Query: 738 DCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVL 795
D + G ++ PR CP VY IM CWQ EP+ R S + RLQ Q P V +L
Sbjct: 673 DFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLL 730
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
sapiens]
Length = 1030
Score = 223 bits (569), Expect = 4e-58
Identities = 175/593 (29%), Positives = 268/593 (45%), Gaps = 56/593 (9%)
Query: 204 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL------GLTLANVTSD 257
SV+V D RC AG I E + V+ LP L A VT D
Sbjct: 470 SVEVYDGTWYRCMSS----TPAGSI--EAQARVQVLDGSSLPEWVTDNAGTLHFARVTRD 523
Query: 258 LNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPS 312
+ N TC A N +++V V ++F + T + H + G P P
Sbjct: 524 -DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPL 582
Query: 313 LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 372
++W +L+ T L P + ++G L ++ ++G YT +A N
Sbjct: 583 IQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 635
Query: 373 SIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFL 432
+D P E P G P K G+SV +A ++
Sbjct: 636 EAPLYVVDKPVPEESEGP--------------GSPPPYKMIQTIGLSVGAAVA-----YI 676
Query: 433 STLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHI 490
+L ++ C +R K +P PE S+ E + L
Sbjct: 677 IAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGP 736
Query: 491 IENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEAS 550
+ S + H R + LG+ FG+VFLA+ L + LV VK+L+
Sbjct: 737 AATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKD 796
Query: 551 ESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGPDAK 609
E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S D K
Sbjct: 797 EQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEK 856
Query: 610 LLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDF 669
L + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+
Sbjct: 857 LKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL 909
Query: 670 GMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWY 729
G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+ P
Sbjct: 910 GLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHG 968
Query: 730 QLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 781
++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 969 GQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
Score = 40.0 bits (92), Expect = 0.009
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
G LLRC+VE G W+L T + SL + D C A
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
Query: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
Query: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
Query: 371 SAS 373
+S
Sbjct: 210 CSS 212
Score = 30.8 bits (68), Expect = 5.2
Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 21/139 (15%)
Query: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
Query: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
Query: 362 LAANPFGQASASIMAAFMD 380
+++ P G A +D
Sbjct: 482 MSSTPAGSIEAQARVQVLD 500
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 222 bits (565), Expect = 1e-57
Identities = 187/627 (29%), Positives = 278/627 (44%), Gaps = 66/627 (10%)
Query: 204 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGL----PSLGLTLANVTSDLN 259
+V G+ V RC G W L + + + GG+ L + +V +
Sbjct: 161 AVPAGNTVKFRCPAAGNPTPTIRW-LKDGQAFHGENRIGGIRLRHQHWSLVMESVVPS-D 218
Query: 260 RKNVTCWAENDVGRAEVSVQVNV------------SFPASVQLHTAVEMHHWCIPFSVDG 307
R TC EN VG + ++V PA+ ++ C +S D
Sbjct: 219 RGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS-DA 277
Query: 308 QPAPSLRWL----FNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363
QP ++WL NGS F + + L+ A + L L + + G YT LA
Sbjct: 278 QP--HIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
Query: 364 ANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVG 423
N G + S + PE+ D T+ P + + S ++
Sbjct: 336 GNSIGLSYQSAWLTVL-------PEE---------DPTWTAAAPEARYTDIILYASGSLA 379
Query: 424 LAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKG 483
LAV L L+ L GR + PA + ++ F GSS +
Sbjct: 380 LAVL--LLLAGLYRGQALHGRHPR----PPATVQKLSRFPLARQFSLESGSSGKSSSSLV 433
Query: 484 SGLQGHIIENPQYFSDAC--------VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPE 535
G++ P + + R +VL LGEG FG+V AE + P
Sbjct: 434 RGVRLSS-SGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPA 492
Query: 536 QDKML--VAVKALKE-ASESARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEY 591
+ VAVK LK+ AS+ D E E++ ++ +H++I+ GVCT+ PL ++ E
Sbjct: 493 RPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVEC 552
Query: 592 MRHGDLNRFLRSH---GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH 648
G+L FLR+ GPD L G + GPL L++ A QVA GM YL +H
Sbjct: 553 AAKGNLREFLRARRPPGPD--LSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIH 610
Query: 649 RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTES 708
RDLA RN LV + V+KI DFG++R ++ DYY+ LP++WM PE++ R +T +S
Sbjct: 611 RDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQS 670
Query: 709 DVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREP 768
DVWSFG++LWEIFT G P+ + E + +G ++RP CPPE+Y +MR CW P
Sbjct: 671 DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAP 730
Query: 769 QQRHSIKD-VHARLQALAQAPPVYLDV 794
QR + K V A + L YLD+
Sbjct: 731 SQRPTFKQLVEALDKVLLAVSEEYLDL 757
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 222 bits (565), Expect = 1e-57
Identities = 187/627 (29%), Positives = 278/627 (44%), Gaps = 66/627 (10%)
Query: 204 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGL----PSLGLTLANVTSDLN 259
+V G+ V RC G W L + + + GG+ L + +V +
Sbjct: 161 AVPAGNTVKFRCPAAGNPTPTIRW-LKDGQAFHGENRIGGIRLRHQHWSLVMESVVPS-D 218
Query: 260 RKNVTCWAENDVGRAEVSVQVNV------------SFPASVQLHTAVEMHHWCIPFSVDG 307
R TC EN VG + ++V PA+ ++ C +S D
Sbjct: 219 RGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYS-DA 277
Query: 308 QPAPSLRWL----FNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363
QP ++WL NGS F + + L+ A + L L + + G YT LA
Sbjct: 278 QP--HIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLA 335
Query: 364 ANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVG 423
N G + S + PE+ D T+ P + + S ++
Sbjct: 336 GNSIGLSYQSAWLTVL-------PEE---------DPTWTAAAPEARYTDIILYASGSLA 379
Query: 424 LAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKG 483
LAV L L+ L GR + PA + ++ F GSS +
Sbjct: 380 LAVL--LLLAGLYRGQALHGRHPR----PPATVQKLSRFPLARQFSLESGSSGKSSSSLV 433
Query: 484 SGLQGHIIENPQYFSDAC--------VHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPE 535
G++ P + + R +VL LGEG FG+V AE + P
Sbjct: 434 RGVRLSS-SGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPA 492
Query: 536 QDKML--VAVKALKE-ASESARQDFQREAELLTML-QHQHIVRFFGVCTEGRPLLMVFEY 591
+ VAVK LK+ AS+ D E E++ ++ +H++I+ GVCT+ PL ++ E
Sbjct: 493 RPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVEC 552
Query: 592 MRHGDLNRFLRSH---GPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVH 648
G+L FLR+ GPD L G + GPL L++ A QVA GM YL +H
Sbjct: 553 AAKGNLREFLRARRPPGPD--LSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIH 610
Query: 649 RDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTES 708
RDLA RN LV + V+KI DFG++R ++ DYY+ LP++WM PE++ R +T +S
Sbjct: 611 RDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQS 670
Query: 709 DVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREP 768
DVWSFG++LWEIFT G P+ + E + +G ++RP CPPE+Y +MR CW P
Sbjct: 671 DVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAP 730
Query: 769 QQRHSIKD-VHARLQALAQAPPVYLDV 794
QR + K V A + L YLD+
Sbjct: 731 SQRPTFKQLVEALDKVLLAVSEEYLDL 757
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 222 bits (565), Expect = 1e-57
Identities = 162/542 (29%), Positives = 252/542 (46%), Gaps = 44/542 (8%)
Query: 249 LTLANVTSDLNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPF 303
L A VT D + N TC A N +++V V ++F + T + H +
Sbjct: 555 LHFARVTRD-DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQC 613
Query: 304 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLA 363
G P P ++W +L+ T L P + ++G L ++ ++G YT +A
Sbjct: 614 EAQGDPKPLIQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIA 666
Query: 364 ANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVG 423
N +D P E P G P K G+SV
Sbjct: 667 GNSCNIKHTEAPLYVVDKPVPEESEGP--------------GSPPPYKMIQTIGLSVGAA 712
Query: 424 LAVFACLFLSTLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEG 481
+A ++ +L ++ C +R K +P PE S+ E
Sbjct: 713 VA-----YIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEV 767
Query: 482 KGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLV 541
+ L + S + H R + LG+ FG+VFLA+ L + LV
Sbjct: 768 ALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLV 827
Query: 542 AVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFL 601
VK+L+ E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FL
Sbjct: 828 LVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFL 887
Query: 602 R-SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 660
R S D KL + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV
Sbjct: 888 RISKSKDEKLKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA 940
Query: 661 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI 720
VK+ G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+
Sbjct: 941 QRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEV 999
Query: 721 FTYGKQPWYQLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA 779
FT+G+ P ++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ +
Sbjct: 1000 FTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIAS 1059
Query: 780 RL 781
L
Sbjct: 1060 AL 1061
Score = 40.0 bits (92), Expect = 0.009
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
G LLRC+VE G W+L T + SL + D C A
Sbjct: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
Query: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
Query: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
Query: 371 SAS 373
+S
Sbjct: 210 CSS 212
Score = 30.8 bits (68), Expect = 5.2
Identities = 37/164 (22%), Positives = 62/164 (37%), Gaps = 32/164 (19%)
Query: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
Query: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
Query: 362 LAANPFG----QASASIMAAFMDNP-------FEFNPEDPIPVS 394
+++ P G QA ++ P EF+ E +P S
Sbjct: 482 MSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCS 525
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,082,576
Number of Sequences: 37866
Number of extensions: 1586219
Number of successful extensions: 7356
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 588
Number of HSP's successfully gapped in prelim test: 399
Number of HSP's that attempted gapping in prelim test: 4259
Number of HSP's gapped (non-prelim): 2081
length of query: 796
length of database: 18,247,518
effective HSP length: 110
effective length of query: 686
effective length of database: 14,082,258
effective search space: 9660428988
effective search space used: 9660428988
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.