Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 13129124
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13129124 caspase recruitment domain protein 14 isoform 1
[Homo sapiens]
(1004 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13129124 caspase recruitment domain protein 14 isoform 1 [Hom... 1988 0.0
gi|16507955 caspase recruitment domain protein 14 isoform 2 [Hom... 740 0.0
gi|157743265 caspase recruitment domain family, member 11 [Homo ... 434 e-121
gi|51093861 caspase recruitment domain protein 10 [Homo sapiens] 304 2e-82
gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo... 180 7e-45
gi|47717131 caspase recruitment domain protein 9 isoform 1 [Homo... 180 7e-45
gi|31982906 cingulin-like 1 [Homo sapiens] 77 6e-14
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 73 1e-12
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 73 1e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 69 2e-11
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 67 8e-11
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 67 1e-10
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 65 2e-10
gi|10092691 tight junction protein 3 [Homo sapiens] 65 4e-10
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 65 4e-10
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 64 5e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 64 5e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 64 7e-10
gi|46852390 coiled-coil domain containing 6 [Homo sapiens] 64 7e-10
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 64 9e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 63 1e-09
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 63 1e-09
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 63 2e-09
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 62 2e-09
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 62 2e-09
gi|212276078 leucine rich repeat (in FLII) interacting protein 1... 62 4e-09
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 62 4e-09
gi|71061468 centromere protein E [Homo sapiens] 62 4e-09
gi|33946313 ninein isoform 4 [Homo sapiens] 62 4e-09
gi|33946321 ninein isoform 5 [Homo sapiens] 62 4e-09
>gi|13129124 caspase recruitment domain protein 14 isoform 1 [Homo
sapiens]
Length = 1004
Score = 1988 bits (5149), Expect = 0.0
Identities = 1004/1004 (100%), Positives = 1004/1004 (100%)
Query: 1 MGELCRRDSALTALDEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHS 60
MGELCRRDSALTALDEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHS
Sbjct: 1 MGELCRRDSALTALDEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHS 60
Query: 61 PRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLME 120
PRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLME
Sbjct: 61 PRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLME 120
Query: 121 TSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRM 180
TSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRM
Sbjct: 121 TSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRM 180
Query: 181 KREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVS 240
KREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVS
Sbjct: 181 KREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVS 240
Query: 241 SCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQE 300
SCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQE
Sbjct: 241 SCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQE 300
Query: 301 LVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKE 360
LVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKE
Sbjct: 301 LVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKE 360
Query: 361 RDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEART 420
RDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEART
Sbjct: 361 RDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEART 420
Query: 421 REPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPS 480
REPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPS
Sbjct: 421 REPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPS 480
Query: 481 QQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDYELLDTADLPQLESSL 540
QQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDYELLDTADLPQLESSL
Sbjct: 481 QQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDYELLDTADLPQLESSL 540
Query: 541 QPVSPGRLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTP 600
QPVSPGRLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTP
Sbjct: 541 QPVSPGRLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHRVTP 600
Query: 601 GSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTDG 660
GSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTDG
Sbjct: 601 GSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTDG 660
Query: 661 YKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNEVLHVTDTMFQGCGCWHAHR 720
YKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNEVLHVTDTMFQGCGCWHAHR
Sbjct: 661 YKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNEVLHVTDTMFQGCGCWHAHR 720
Query: 721 VNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTRKPSSGGPQKLVRIVSMDKAK 780
VNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTRKPSSGGPQKLVRIVSMDKAK
Sbjct: 721 VNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTRKPSSGGPQKLVRIVSMDKAK 780
Query: 781 ASPLRLSFDRGQLDPSRMEGSSTCFWAESCLTLVPYTLVWPHRPARPRPVLLVPRAVGKI 840
ASPLRLSFDRGQLDPSRMEGSSTCFWAESCLTLVPYTLVWPHRPARPRPVLLVPRAVGKI
Sbjct: 781 ASPLRLSFDRGQLDPSRMEGSSTCFWAESCLTLVPYTLVWPHRPARPRPVLLVPRAVGKI 840
Query: 841 LSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTH 900
LSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTH
Sbjct: 841 LSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTH 900
Query: 901 ALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDL 960
ALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDL
Sbjct: 901 ALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDL 960
Query: 961 DRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR 1004
DRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR
Sbjct: 961 DRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR 1004
>gi|16507955 caspase recruitment domain protein 14 isoform 2 [Homo
sapiens]
Length = 434
Score = 740 bits (1910), Expect = 0.0
Identities = 381/381 (100%), Positives = 381/381 (100%)
Query: 238 MVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGS 297
MVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGS
Sbjct: 1 MVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGS 60
Query: 298 RQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCEL 357
RQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCEL
Sbjct: 61 RQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCEL 120
Query: 358 QKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQE 417
QKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQE
Sbjct: 121 QKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQE 180
Query: 418 ARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPA 477
ARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPA
Sbjct: 181 ARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPA 240
Query: 478 PPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDYELLDTADLPQLE 537
PPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDYELLDTADLPQLE
Sbjct: 241 PPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDYELLDTADLPQLE 300
Query: 538 SSLQPVSPGRLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHR 597
SSLQPVSPGRLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHR
Sbjct: 301 SSLQPVSPGRLDVSESGVLMRRRPARRILSQVTMLAFQGDALLEQISVIGGNLTGIFIHR 360
Query: 598 VTPGSAADQMALRPGTQIVMV 618
VTPGSAADQMALRPGTQIVMV
Sbjct: 361 VTPGSAADQMALRPGTQIVMV 381
>gi|157743265 caspase recruitment domain family, member 11 [Homo
sapiens]
Length = 1154
Score = 434 bits (1115), Expect = e-121
Identities = 341/1147 (29%), Positives = 548/1147 (47%), Gaps = 173/1147 (15%)
Query: 15 DEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLL 74
+E+ LWE +E +RH + R I P++LTPYLRQ KV+ + DE+EVL++P L + RAG LL
Sbjct: 18 EEDALWENVECNRHMLSRYINPAKLTPYLRQCKVIDEQDEDEVLNAPMLPSKINRAGRLL 77
Query: 75 DLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGS 134
D+L T+G+ G + FLESL+F+ P++Y LVTG +P FS LT L +
Sbjct: 78 DILHTKGQRGYVVFLESLEFYYPELYKLVTGKEPTRRFSTIVVEEGHEGLTHFLMNEVIK 137
Query: 135 LQEELNQEKGQKEVLLRRCQQLQ-EHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLR 193
LQ+++ + Q+ LL R +QL+ E + TR E L + + +MK E ++ E+++
Sbjct: 138 LQQQMKAKDLQRCELLARLRQLEDEKKQMTLTRVE-LLTFQERYYKMKEERDSYNDELVK 196
Query: 194 LKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRT 253
+KD+ +L++ Y+ +EK +A R R LQ E+ LK L + M C+LE + QSL+
Sbjct: 197 VKDDNYNLAMRYAQLSEEKNMAVMRSRDLQLEIDQLKHRLNK--MEEECKLE-RNQSLKL 253
Query: 254 ASDQES--GDEELNRLKEENEKLRSLTFSL----------------AEKDILEQSLDEAR 295
+D E+ E++ L+ ENE L++ L A DILE EA
Sbjct: 254 KNDIENRPKKEQVLELERENEMLKTKNQELQSIIQAGKRSLPDSDKAILDILEHDRKEAL 313
Query: 296 GSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVC 355
RQELV RI++L+E A AE R++Y EEKE L+ C++Y+ ++N + Q+
Sbjct: 314 EDRQELVNRIYNLQEEARQAEELRDKYLEEKEDLELKCSTLGKDCEMYKHRMNTVMLQLE 373
Query: 356 ELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQ--------------VCELRT 401
E+++ERDQA+ +RD AQ + SQ L+EKD R+Q+ EL ++ + L +
Sbjct: 374 EVERERDQAFHSRDEAQTQYSQCLIEKDKYRKQIRELEEKNDEMRIEMVRREACIVNLES 433
Query: 402 QLRQLQAE------------PPGVLKQ---------------EARTREPCPREKQRLVRM 434
+LR+L + P ++ Q ++ T E P + + +
Sbjct: 434 KLRRLSKDSNNLDQSLPRNLPVTIISQDFGDASPRTNGQEADDSSTSEESPEDSKYFLPY 493
Query: 435 H------------------AICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSP 476
H I + SD E + S+ S + +SF P
Sbjct: 494 HPPQRRMNLKGIQLQRAKSPISLKRTSDFQAKGHEEEGTDASPSSCGSLPITNSFTKMQP 553
Query: 477 ------------APPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLD 524
PP S+ +R ED S +E + D G D +
Sbjct: 554 PRSRSSIMSITAEPPGNDSIVRRYKEDAPHR-----STVE-EDNDSGGFDALDLDDDSHE 607
Query: 525 YELLDTADLPQLESSLQPVSPGRLDVSESGVLMRR----RPARRILSQVTML-------- 572
+ + SS Q D+ + ++ R+ RP R ++ V +
Sbjct: 608 RYSFGPSSIHSSSSSHQSEGLDAYDLEQVNLMFRKFSLERPFRPSVTSVGHVRGPGPSVQ 667
Query: 573 --AFQGDALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAV 630
GD+L Q++++GGN G F+H V PGS A++ LR G Q+++++
Sbjct: 668 HTTLNGDSLTSQLTLLGGNARGSFVHSVKPGSLAEKAGLREGHQLLLLEGCIRGERQSVP 727
Query: 631 LEDTTLEEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGR 690
L+ T EEA ++R G L KVN +GY++L++D+E + TSGDSFYIR+NL + +
Sbjct: 728 LDTCTKEEAHWTIQRCSGPVTLHYKVNHEGYRKLVKDMEDGLITSGDSFYIRLNLNISSQ 787
Query: 691 AKG-ELQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPNYSRAQQQLIALI 749
+ + C++V+HV DTM+Q W RV+ +T D GTIP+YSRAQQ L+ +
Sbjct: 788 LDACTMSLKCDDVVHVRDTMYQDRHEWLCARVDPFTDHDLDM-GTIPSYSRAQQLLLVKL 846
Query: 750 QDMTQQ---------------CTVTRKP----SSGGPQ-------------KLVRIVSMD 777
Q + + T +P S+ P+ +L++ VS
Sbjct: 847 QRLMHRGSREEVDGTHHTLRALRNTLQPEEALSTSDPRVSPRLSRASFLFGQLLQFVSRS 906
Query: 778 KAK--------------ASPL----RLSFDRGQLDPSRMEGSSTCFWAESCLTLVPYTLV 819
+ K SPL R S D +L + E L+L+PY+LV
Sbjct: 907 ENKYKRMNSNERVRIISGSPLGSLARSSLDATKLLTEKQEELDPESELGKNLSLIPYSLV 966
Query: 820 WPHRPARPRPVLLVPRAVGKILSEKLCLLQG---FKKCLAEYLSQEEYEAWSQRGDII-- 874
R RPVL P + K L ++L G F C ++ ++++E+ + II
Sbjct: 967 RAFYCERRRPVLFTPTVLAKTLVQRLLNSGGAMEFTICKSDIVTRDEFLRRQKTETIIYS 1026
Query: 875 QEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKK 934
+E + C + +E++ KN H LL+ + L + +I+PIV+ + V EK K+
Sbjct: 1027 REKNPNAFEC-IAPANIEAVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLFIRVCEKNIKR 1085
Query: 935 LKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQK 994
+K L R T EE+ L R +E +L+ PCLY+++ PD W ++ LL V+ I +EQ+
Sbjct: 1086 FRKLLPRPET-EEEFLRVCRLKEKELEALPCLYATVEPDMWGSVEELLRVVKDKIGEEQR 1144
Query: 995 KVVWTEQ 1001
K +W ++
Sbjct: 1145 KTIWVDE 1151
>gi|51093861 caspase recruitment domain protein 10 [Homo sapiens]
Length = 1032
Score = 304 bits (779), Expect = 2e-82
Identities = 302/1056 (28%), Positives = 470/1056 (44%), Gaps = 129/1056 (12%)
Query: 15 DEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLL 74
+E+ LWE +E RHR+ R + P++LTPYLRQ +V+ + DEEEVL + R R G L+
Sbjct: 23 EEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQDEEEVLSTYRFPCRVNRTGRLM 82
Query: 75 DLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGS 134
D+L+ RGK G AFLE+L+F+ P+ +TL+TG +P S LT+ L +
Sbjct: 83 DILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRCSMILDEEGPEGLTQFLMTEVRR 142
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRL 194
L+E + +++ L R + L+E E R Q + R++ + A E+LRL
Sbjct: 143 LREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQAQERCQRLREDWEAGSLELLRL 202
Query: 195 KDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTA 254
KDE +++ + +EK A R R LQ + LK ++ R + C L + +
Sbjct: 203 KDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLKVSR--LEEECALLRRARGPPPG 260
Query: 255 SDQESGDEE----------LNRLKEENEKLRSLTFSLAE------------------KDI 286
++++ ++E ++ L+ EN++L + L E DI
Sbjct: 261 AEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEGLQQEASRPGAPGSERILLDI 320
Query: 287 LEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREK 346
LE EA+ SRQEL +++H+++ AE R+QY +E E L+ + + C LY+ +
Sbjct: 321 LEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEMEDLRLKHRTLQKDCDLYKHR 380
Query: 347 VNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQL 406
+ + AQ+ E++KERDQA +RD Q + SQSL+EKD R+QV L + EL T L L
Sbjct: 381 MATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYRKQVRGLEAERDELLTTLTSL 440
Query: 407 QAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSL----------VSSTESQLL 456
E L + R + H++C S SL ++ E+ ++
Sbjct: 441 --EGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLSEFPSPLGGPEATGEAAVM 498
Query: 457 SDLSATSSRELVDSFR-----SSSPAPPSQQSLYKRVAEDFGEEP-WSFSSCLEIPEGDP 510
+S E DS + S P PPS S+ +R E+ P SFSS +I G
Sbjct: 499 GGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDPAPPKRSFSSMSDI-TGSV 557
Query: 511 GALPGAKAGDPHLDYELLDTADLPQLESSLQPVSPGRLDVSESGVLMRRRPARRILSQVT 570
P + P L SS S L E L+ R L++
Sbjct: 558 TLKPWS-----------------PGLSSSSSSDSVWPLGKPEG--LLARGCGLDFLNRSL 598
Query: 571 MLAFQG----------DALLEQISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDY 620
+ G D + +S G +G + RV G + +M R ++
Sbjct: 599 AIRVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPRE-QRVEAAGL 657
Query: 621 EASEPLFKAVLEDTTL--EEAVGLLRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATSGDS 678
E + +A + TL + L +D C S + + + +
Sbjct: 658 EGA--CLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAK---------GPGAEP 706
Query: 679 FYIRVNLAMEGRAKGE-LQVHCNEVLHVTDTMFQGCGCWHAHRVNSYTMKDTAAHGTIPN 737
FYIR NL + RA L V E+L + D+ ++ W RV+ T++D GT+PN
Sbjct: 707 FYIRANLTLPERADPHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRD-LDRGTVPN 765
Query: 738 YSRAQQQLIALIQDMTQQCTVTRKPSS--GGPQKLVRIVSMD-------KAKASPLRLSF 788
Y RAQQ L ++ ++C PSS GP+ ++ ++D K +P S
Sbjct: 766 YQRAQQLL-----EVQEKCL----PSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSP 816
Query: 789 DRGQLDPSRMEGSSTCFWAESCLTLVPYTLVWPHRPARPRPVLLVPRAVGKILSEKLCLL 848
D+ L+P AE +L PY+LV P + RPV+L+P + L L L
Sbjct: 817 DQLLLEPC----------AEPERSLRPYSLVRPLLVSALRPVVLLPECLAPRLIRNLLDL 866
Query: 849 QG----FKKCLAEYLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLD 904
F+ C AE LS EE S G + G + R ES+ +K H LL+
Sbjct: 867 PSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPATPGLGSRI-RAIQESVGKK--HCLLE 923
Query: 905 VQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAP 964
+ V L + +I+PIVIHV V EK ++++ L R G + +LL R E L P
Sbjct: 924 LGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGRPGWRDSELLRQCRGSEQVLWGLP 983
Query: 965 CLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTE 1000
C + + W + L VR I EQ ++VW E
Sbjct: 984 CSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVE 1019
>gi|16554562 caspase recruitment domain protein 9 isoform 2 [Homo
sapiens]
Length = 492
Score = 180 bits (456), Expect = 7e-45
Identities = 143/464 (30%), Positives = 222/464 (47%), Gaps = 38/464 (8%)
Query: 15 DEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLL 74
+++ W ++E R + I PSR+TPYLRQ KVL DEE+VL P L + G LL
Sbjct: 6 NDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLL 65
Query: 75 DLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGS 134
D+L+ G G +AFLESL+ + P +Y VTG +P FS S LT+ L +
Sbjct: 66 DILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMK 125
Query: 135 LQ---EELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEV 191
LQ ++L K+ ++ + L + R + R+K E A E+
Sbjct: 126 LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQ----------RLKEECEAGSREL 175
Query: 192 LRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQ-S 250
R K+E L++ ++ +EK A R R LQ E+ LK L +A C++E +
Sbjct: 176 KRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAE--DDCKVERKHTLK 233
Query: 251 LRTASDQESGDEELNRLKEENEKLRSLTFSLAEK-------------DILEQSLDEARGS 297
LR A +Q E L L++E L++ L +LE+ +A
Sbjct: 234 LRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRD 293
Query: 298 RQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCEL 357
QE I SLR+ E +R + EEKE LQ + ++Y++++ A+ Q+ E+
Sbjct: 294 HQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
Query: 358 QKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQE 417
ERDQA + R+ + ++ L EKD+LR+QV EL ++ EL+ Q+ Q +A+ +L E
Sbjct: 354 AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQ---LLAVE 410
Query: 418 ARTREPCPREKQRLVRMHAI---CPRDDSDCSLVSSTESQLLSD 458
R R ++ + LV + PR + SL E LSD
Sbjct: 411 GRLRR---QQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSD 451
>gi|47717131 caspase recruitment domain protein 9 isoform 1 [Homo
sapiens]
Length = 536
Score = 180 bits (456), Expect = 7e-45
Identities = 143/464 (30%), Positives = 222/464 (47%), Gaps = 38/464 (8%)
Query: 15 DEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLL 74
+++ W ++E R + I PSR+TPYLRQ KVL DEE+VL P L + G LL
Sbjct: 6 NDDECWSVLEGFRVTLTSVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVLL 65
Query: 75 DLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGS 134
D+L+ G G +AFLESL+ + P +Y VTG +P FS S LT+ L +
Sbjct: 66 DILQRTGHKGYVAFLESLELYYPQLYKKVTGKEPARVFSMIIDASGESGLTQLLMTEVMK 125
Query: 135 LQ---EELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEV 191
LQ ++L K+ ++ + L + R + R+K E A E+
Sbjct: 126 LQKKVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQ----------RLKEECEAGSREL 175
Query: 192 LRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQ-S 250
R K+E L++ ++ +EK A R R LQ E+ LK L +A C++E +
Sbjct: 176 KRCKEENYDLAMRLAHQSEEKGAALMRNRDLQLEIDQLKHSLMKAE--DDCKVERKHTLK 233
Query: 251 LRTASDQESGDEELNRLKEENEKLRSLTFSLAEK-------------DILEQSLDEARGS 297
LR A +Q E L L++E L++ L +LE+ +A
Sbjct: 234 LRHAMEQRPSQELLWELQQEKALLQARVQELEASVQEGKLDRSSPYIQVLEEDWRQALRD 293
Query: 298 RQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCEL 357
QE I SLR+ E +R + EEKE LQ + ++Y++++ A+ Q+ E+
Sbjct: 294 HQEQANTIFSLRKDLRQGEARRLRCMEEKEMFELQCLALRKDSKMYKDRIEAILLQMEEV 353
Query: 358 QKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQE 417
ERDQA + R+ + ++ L EKD+LR+QV EL ++ EL+ Q+ Q +A+ +L E
Sbjct: 354 AIERDQAIATREELHAQHARGLQEKDALRKQVRELGEKADELQLQVFQCEAQ---LLAVE 410
Query: 418 ARTREPCPREKQRLVRMHAI---CPRDDSDCSLVSSTESQLLSD 458
R R ++ + LV + PR + SL E LSD
Sbjct: 411 GRLRR---QQLETLVLSSDLEDGSPRRSQELSLPQDLEDTQLSD 451
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 77.4 bits (189), Expect = 6e-14
Identities = 73/323 (22%), Positives = 152/323 (47%), Gaps = 36/323 (11%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRL 194
LQEE + +G+ E L RR QLQ + L+ D ++ K + + E+ +L
Sbjct: 827 LQEENEKLQGRSEELERRVAQLQRQI----------EDLKGDEAKAKETLKKYEGEIRQL 876
Query: 195 KDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQ-EQSLRT 253
++ ++ +A +E++ A S R+L+ EL E + N+ + + + Q + L+
Sbjct: 877 EEALV-------HARKEEKEAVSARRALENEL-----EAAQGNLSQTTQEQKQLSEKLKE 924
Query: 254 ASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAV 313
S+Q+ E+L RLK E E R EK + ++ D SR +E + L E
Sbjct: 925 ESEQK---EQLRRLKNEMENERWHLGKTIEK-LQKEMADIVEASRTSTLELQNQLDEYKE 980
Query: 314 AAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQR 373
R+ + + ++ L+ +KS++ ++++ ++ ++ + Q+ +D+A + R ++
Sbjct: 981 KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQ 1040
Query: 374 EISQSLVE-------KDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPR 426
+ E KD R V ++ D+V +L +L + + + ++ +R+RE +
Sbjct: 1041 TLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQ 1100
Query: 427 EKQRLVRMHAICPRDDSDCSLVS 449
+ L++ A R D +C +S
Sbjct: 1101 LRNELLQERA--ARQDLECDKIS 1121
Score = 56.6 bits (135), Expect = 1e-07
Identities = 101/437 (23%), Positives = 196/437 (44%), Gaps = 50/437 (11%)
Query: 4 LCRRDSALTALDEETLWEMMESHRHRIVRCICPSRLTPYLRQAKVLCQLDEE-----EVL 58
L +R+ LTAL + L E + SH + + Y + + L + EE EVL
Sbjct: 753 LRKRERELTAL-KGALKEEVSSHDQEMDKL-----KEQYDAELQALRESVEEATKNVEVL 806
Query: 59 HSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNPDVYTLVTGLQPDVDF--SNFS 116
S T+ +AG + + + +N E L+ + ++ V LQ ++ + +
Sbjct: 807 ASRSNTSEQDQAGTEMRVKLLQEEN------EKLQGRSEELERRVAQLQRQIEDLKGDEA 860
Query: 117 GLMETSKLTECLAGAIGSLQEEL-NQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEA 175
ET K E G I L+E L + K +KE + R + L+ L A+ Q +
Sbjct: 861 KAKETLKKYE---GEIRQLEEALVHARKEEKEAVSAR-RALENELEAAQGNLSQTTQEQK 916
Query: 176 DHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQ--EKELA----ASRCRSLQEELYLL 229
S +E S ++ RLK+EM + H ++ +KE+A ASR +L+ + L
Sbjct: 917 QLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLD 976
Query: 230 KQELQRANMVSSCELELQEQSLRTASDQESG---DEELNRLKEE-NEKLRSLTFSLAEKD 285
+ + + ++ + +L+E++L + + +E+ ++EE + R+ +L ++
Sbjct: 977 EYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQ 1036
Query: 286 ILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYRE 345
+LEQ+L + EL + H +R+ R +Q ++ Q ++ ++ + L E
Sbjct: 1037 LLEQTLKDL---EYELEAKSHLKDDRS----RLVKQMEDKVSQLEMELEEERNNSDLLSE 1089
Query: 346 KVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQ 405
+++ + Q+ +L+ E Q +AR + +K SL RQ +L ++ L R
Sbjct: 1090 RISRSREQMEQLRNELLQERAARQDLE-------CDKISLERQNKDLKSRIIHLEGSYR- 1141
Query: 406 LQAEPPGVLKQEARTRE 422
++ V++ EAR E
Sbjct: 1142 -SSKEGLVVQMEARIAE 1157
Score = 55.1 bits (131), Expect = 3e-07
Identities = 83/362 (22%), Positives = 148/362 (40%), Gaps = 60/362 (16%)
Query: 118 LMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADH 177
L + SKLT +A LQ E+ ++ KE R L+E + E L+
Sbjct: 613 LEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRL 672
Query: 178 SRMKREVSAHFHEVLRLK-----------DEMLSLSLHYSNALQEKELAASRCRSLQEEL 226
+ E+ + E+ ++K D LS + K +L EEL
Sbjct: 673 EESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEEL 732
Query: 227 YLLKQELQ--------RANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLT 278
KQ+LQ + +++ E EL + S D+E+++LKE+ +
Sbjct: 733 LQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYD------ 786
Query: 279 FSLAEKDILEQSLDEARGSRQELVERIHS---------LRERAVAAERQREQ-YWEEKEQ 328
AE L +S++EA + + L R ++ +R + + E ++ Q EE E+
Sbjct: 787 ---AELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELER 843
Query: 329 TLLQFQ-----------KSKMACQLYREKVNALQAQVCELQKERDQAYSAR-------DS 370
+ Q Q K+K + Y ++ L+ + +KE +A SAR ++
Sbjct: 844 RVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEA 903
Query: 371 AQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQR 430
AQ +SQ+ E+ L ++ E ++Q + QLR+L+ E +T E +E
Sbjct: 904 AQGNLSQTTQEQKQLSEKLKEESEQ----KEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959
Query: 431 LV 432
+V
Sbjct: 960 IV 961
Score = 47.0 bits (110), Expect = 9e-05
Identities = 59/244 (24%), Positives = 103/244 (42%), Gaps = 45/244 (18%)
Query: 181 KREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVS 240
KR+V+ F ++ LK S A + C S E LL+Q+ + V+
Sbjct: 575 KRKVNLVFEKIQTLK----------SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVA 624
Query: 241 SCELELQEQSLRTASDQESGDEELNRLKEENEKLRSL-TFSLAEKDILEQSLDEARGSRQ 299
ELQ Q +Q++ EE R++ E+LRS + E L+Q L+E+ G +
Sbjct: 625 ----ELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELR 680
Query: 300 ELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQK 359
+ +E + ++ +REQ+ E + LQ Q+ E+
Sbjct: 681 KNLEELFQVK-------MEREQHQTE---------------------IRDLQDQLSEMHD 712
Query: 360 ERDQAYSARDSAQREISQSLVE-KDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEA 418
E D A + D + + + L++ K L+ + +Q LR + R+L A G LK+E
Sbjct: 713 ELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTA-LKGALKEEV 771
Query: 419 RTRE 422
+ +
Sbjct: 772 SSHD 775
Score = 42.4 bits (98), Expect = 0.002
Identities = 54/263 (20%), Positives = 117/263 (44%), Gaps = 18/263 (6%)
Query: 120 ETSKLTEC-LAGAIGSLQEELNQ-EKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADH 177
E S+LT + + ++EEL ++ Q E L +R Q L++ L E E L+ D
Sbjct: 1001 EKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKR-QLLEQTLKDLEYELEAKSHLKDDR 1059
Query: 178 SRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRAN 237
SR+ V +++D++ L + +L + R +E++ L+ EL +
Sbjct: 1060 SRL----------VKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQER 1109
Query: 238 MVSSCELELQEQSL-RTASDQESGDEELNRLKEENEK--LRSLTFSLAEKDILEQSLDEA 294
+LE + SL R D +S L +++ + + +AE + +S +
Sbjct: 1110 AARQ-DLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERD 1168
Query: 295 RGSRQELVERIH-SLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQ 353
R + Q R+ ++E + + + ++K+Q L+ + K + E+++ L++
Sbjct: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESS 1228
Query: 354 VCELQKERDQAYSARDSAQREIS 376
+LQ+E ++ + Q +++
Sbjct: 1229 KKKLQRELEEQMDMNEHLQGQLN 1251
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 73.2 bits (178), Expect = 1e-12
Identities = 104/422 (24%), Positives = 168/422 (39%), Gaps = 60/422 (14%)
Query: 583 ISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGL 642
+ + GGN GIF+ + G++A+Q L+ G QI+ V+ + L V ED L L
Sbjct: 523 LRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGL---VREDAVLY----L 575
Query: 643 LRRVDG-FCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNE 701
L G + + D Y+ +L GDSF+IR + E L E
Sbjct: 576 LEIPKGEMVTILAQSRADVYRDIL------ACGRGDSFFIRSHFECEKETPQSLAFTRGE 629
Query: 702 VLHVTDTMFQG-CGCWHAHRVNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTR 760
V V DT++ G G W A R+ + K G IPN SRA+Q +A +Q+ +
Sbjct: 630 VFRVVDTLYDGKLGNWLAVRIGNELEK-----GLIPNKSRAEQ--MASVQN-------AQ 675
Query: 761 KPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRMEGSSTCFWAESCLTLVPYTLVW 820
+ ++G R+ + + S ++ + + + D + + ST F A Y V
Sbjct: 676 RDNAGDRADFWRM----RGQRSGVKKNLRKSREDLTAVVSVSTKFPA--------YERVL 723
Query: 821 PHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVS 880
RPV+L + I EKL E W Q + S
Sbjct: 724 LREAGFKRPVVLF-GPIADIAMEKLA---------------NELPDWFQTAKTEPKDAGS 767
Query: 881 GGRCWVTR-HAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGL 939
V R + V ++E++ HALLDV +V L+ FPIVI + + + K +
Sbjct: 768 EKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMR-- 825
Query: 940 QRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWT 999
QRL + + + L + + + S D ++ I +Q + VW
Sbjct: 826 QRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
Query: 1000 EQ 1001
+
Sbjct: 886 SE 887
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 73.2 bits (178), Expect = 1e-12
Identities = 104/422 (24%), Positives = 168/422 (39%), Gaps = 60/422 (14%)
Query: 583 ISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGL 642
+ + GGN GIF+ + G++A+Q L+ G QI+ V+ + L V ED L L
Sbjct: 523 LRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGL---VREDAVLY----L 575
Query: 643 LRRVDG-FCCLSVKVNTDGYKRLLQDLEAKVATSGDSFYIRVNLAMEGRAKGELQVHCNE 701
L G + + D Y+ +L GDSF+IR + E L E
Sbjct: 576 LEIPKGEMVTILAQSRADVYRDIL------ACGRGDSFFIRSHFECEKETPQSLAFTRGE 629
Query: 702 VLHVTDTMFQG-CGCWHAHRVNSYTMKDTAAHGTIPNYSRAQQQLIALIQDMTQQCTVTR 760
V V DT++ G G W A R+ + K G IPN SRA+Q +A +Q+ +
Sbjct: 630 VFRVVDTLYDGKLGNWLAVRIGNELEK-----GLIPNKSRAEQ--MASVQN-------AQ 675
Query: 761 KPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRMEGSSTCFWAESCLTLVPYTLVW 820
+ ++G R+ + + S ++ + + + D + + ST F A Y V
Sbjct: 676 RDNAGDRADFWRM----RGQRSGVKKNLRKSREDLTAVVSVSTKFPA--------YERVL 723
Query: 821 PHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQEGEVS 880
RPV+L + I EKL E W Q + S
Sbjct: 724 LREAGFKRPVVLF-GPIADIAMEKLA---------------NELPDWFQTAKTEPKDAGS 767
Query: 881 GGRCWVTR-HAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGL 939
V R + V ++E++ HALLDV +V L+ FPIVI + + + K +
Sbjct: 768 EKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMR-- 825
Query: 940 QRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWT 999
QRL + + + L + + + S D ++ I +Q + VW
Sbjct: 826 QRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
Query: 1000 EQ 1001
+
Sbjct: 886 SE 887
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 69.3 bits (168), Expect = 2e-11
Identities = 98/417 (23%), Positives = 177/417 (42%), Gaps = 56/417 (13%)
Query: 103 VTGLQPDVDFSNF---SGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEH 159
V GL+PD + + G + T+ E +A A+ L ++L + + ++VL + Q+L+E
Sbjct: 1213 VWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEER 1272
Query: 160 LGLAETRAEGLH-----------QLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNA 208
L E +H Q + + S+ + + ++ E++ L + M SL A
Sbjct: 1273 LTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRA 1332
Query: 209 -LQEKELAASR--CRSLQEELYLLKQELQRANMVSSCELE---LQEQSLRTASD------ 256
LQ E R ++ +E L + LQ A + + + + E+ LRTA
Sbjct: 1333 ELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKN 1392
Query: 257 -------------QESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVE 303
QE G+ ++ + K E L LT +LAE+ E+ ++ RG QEL +
Sbjct: 1393 EEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAER---EEEVETLRGQIQELEK 1449
Query: 304 RIH-----------SLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQA 352
+ L++R + Q+EQ +E E+ + MA Q +K+ +
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQI-QELEKCRSVLEHLPMAVQEREQKLTVQRE 1508
Query: 353 QVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPG 412
Q+ EL+K+R+ + + E+ + +S R QV +L Q+ L +L+
Sbjct: 1509 QIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHK 1568
Query: 413 VLKQEARTRE-PCPREKQRLVRMHAICPRDDSDCSL-VSSTESQLLSDLSATSSREL 467
+ Q+ +E RE QR+ H ++ L S++ L S +REL
Sbjct: 1569 MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLAREL 1625
Score = 59.7 bits (143), Expect = 1e-08
Identities = 89/354 (25%), Positives = 151/354 (42%), Gaps = 54/354 (15%)
Query: 120 ETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSR 179
E + E LA A+ +E L +EK EV L+ ++ ++ L AE L L +
Sbjct: 716 EAKRQEEVLARAVQE-KEALVREKAALEVRLQAVERDRQDL------AEQLQGLSSAKEL 768
Query: 180 MKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMV 239
++ + + ++ L + Q KE+ R L+ EL + + ++
Sbjct: 769 LESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDA 828
Query: 240 SSCELELQEQSLRTASDQESG--DEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGS 297
++ +L EQ +TA +Q+ ++E+N+L+E+ EK RS + L ++L+
Sbjct: 829 AARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSW-----HQQELAKALESLERE 883
Query: 298 RQELVERIHSLRERAVAAERQRE-------------QYWEEKE-----QTLLQFQK--SK 337
+ EL R+ + A + QRE Q EKE +TLLQ QK +
Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
Query: 338 MACQLYR-------------EKVNALQAQVCELQKE-RDQAYSARD---SAQREISQSLV 380
+ QL R E LQ Q+ E Q+E ++ A RD + Q E S L
Sbjct: 944 ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Query: 381 EKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEA---RTREPCPREKQRL 431
+K L++QV +L Q+ R ++ E L++ R ++ REK L
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
Score = 56.6 bits (135), Expect = 1e-07
Identities = 89/379 (23%), Positives = 144/379 (37%), Gaps = 88/379 (23%)
Query: 134 SLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSA------- 186
+L+ E + Q+E R + LQE LG A +G Q + + + R + A
Sbjct: 1944 ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA 2003
Query: 187 ----------HFHEVLRLKD-EMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQR 235
E LR+++ E+ L Y +Q+ + A + Q + L Q+ +
Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALA-----QRDEELRHQQERE 2058
Query: 236 ANMVSSCELELQEQSLRTASD--QESGDEELNRLKEENEKLRSLTFSLAEKDILE----- 288
+ S +QE ++ + QE +EE+ L + +L+ LT + E++ILE
Sbjct: 2059 QLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ-LTLAQKEQEILELRETQ 2117
Query: 289 --------------QSLDEARGSRQELVERIHSLRERAVAAERQ---REQYWEEKEQTL- 330
++E L R+ ER AA RQ RE W EK Q L
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLA 2177
Query: 331 LQFQKSKMACQLYREKVNALQAQVCE------------------LQKERDQAYSARDSA- 371
L ++K + +E LQA V E L+KER + A +A
Sbjct: 2178 LSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAE 2237
Query: 372 -----------------QREISQSLVEKDSLRRQVFELTDQVCEL---RTQLRQLQAEPP 411
+ E S +EK S R+++ L V L R++L++ +
Sbjct: 2238 LGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLR 2297
Query: 412 GVLKQEARTREPCPREKQR 430
L+Q R R RE R
Sbjct: 2298 STLEQVERERRKLKREAMR 2316
Score = 53.9 bits (128), Expect = 7e-07
Identities = 79/362 (21%), Positives = 152/362 (41%), Gaps = 46/362 (12%)
Query: 135 LQEELNQ------EKGQKEVLLRRCQQLQEHLGLAETRAE--GLHQLEADHSRMKREVSA 186
L+E+L Q E+G++ R+ Q + G ++A+ L ++ ++EV
Sbjct: 1681 LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC 1740
Query: 187 ---HFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCE 243
H HE+ LKD++ + E L S+ ++E+ +L+Q+LQ A
Sbjct: 1741 QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQ---REQEIVVLQQQLQEAREQG--- 1794
Query: 244 LELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVE 303
EL+EQSL++ D E R+L E + L+Q +A+G + + E
Sbjct: 1795 -ELKEQSLQSQLD---------------EAQRALAQRDQELEALQQEQQQAQGQEERVKE 1838
Query: 304 RIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQ 363
+ +L+ A ++ E + Q ++ + + +V AL+ + +L+ E +
Sbjct: 1839 KADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESRE 1898
Query: 364 AYSARDSAQREISQSL----VEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEAR 419
A + Q++ ++ VE +L+ + + E +L L+AE QE
Sbjct: 1899 QEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEA 1958
Query: 420 TREPCPREKQRLVRMHA--------ICPRDDSDCSLVSSTES-QLLSDLSATSSRELVDS 470
R ++ L + HA + + + SL +ST + Q D SR+L ++
Sbjct: 1959 ARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEA 2018
Query: 471 FR 472
R
Sbjct: 2019 LR 2020
Score = 53.5 bits (127), Expect = 1e-06
Identities = 82/326 (25%), Positives = 137/326 (42%), Gaps = 39/326 (11%)
Query: 122 SKLTECLAGAIGSLQEELN-------QEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLE 174
S LT CL +G+ E N +E Q +LL + Q+L++ A R++ L QL+
Sbjct: 215 SLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKE---AHERSQELIQLK 271
Query: 175 ADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSN---ALQEK------------ELAASRC 219
+ K E+ E+ L + + Y AL+E E AS
Sbjct: 272 SQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLS 331
Query: 220 RSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTF 279
R+ QEE L+Q ++ V + E+ A Q SG E N L+ ++ +
Sbjct: 332 RNAQEEKLSLQQVIKDITQV------MVEEGDNIA--QGSGHE--NSLELDSSIFSQFDY 381
Query: 280 SLAEK--DILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQ-FQKS 336
A+K ++ L R + Q+L +++ +E ++Q +Q WEE+ + L Q QK
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQ-WEEEGKALRQRLQKL 440
Query: 337 KMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQV 396
+ LQ +V L KER+ AR+ ++++ E LRR EL Q
Sbjct: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQG 500
Query: 397 CELRTQLRQLQAEPPGVLKQEARTRE 422
+ Q + Q E +++ R +E
Sbjct: 501 DSAQGQKEEQQEELHLAVRERERLQE 526
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/330 (18%), Positives = 128/330 (38%), Gaps = 13/330 (3%)
Query: 118 LMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADH 177
L E EC I L+ Q + Q+ L L+E + ++ +H LE+
Sbjct: 1562 LEENHHKMECQQKLIKELE---GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHS 1618
Query: 178 SRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRAN 237
+ + RE+ EV ++++ L + Q+ E +E + +L+ + R
Sbjct: 1619 TVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQT 1678
Query: 238 MVSSCELELQEQSLRTASD---------QESGDEELNRLKEENEKLRSLTFSLAEKDILE 288
+ +LE + SLR QE +E K + L + L +K+
Sbjct: 1679 KILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEV 1738
Query: 289 QSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYRE-KV 347
+ E QEL +++ + + ++EQ ++ Q+ + E K
Sbjct: 1739 ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKE 1798
Query: 348 NALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQ 407
+LQ+Q+ E Q+ Q ++ Q+E Q+ +++ ++ + L + + L++
Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858
Query: 408 AEPPGVLKQEARTREPCPREKQRLVRMHAI 437
E +Q R E E +R+ + +
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEV 1888
Score = 47.4 bits (111), Expect = 7e-05
Identities = 69/335 (20%), Positives = 135/335 (40%), Gaps = 42/335 (12%)
Query: 126 ECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKRE-- 183
+ L GA+ L + G+ + + ++L+E L + R + L ++ D RE
Sbjct: 1841 DALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQE 1900
Query: 184 -----------VSAHFHE---------------VLRLKD-EMLSLSLHYSNALQEKELAA 216
A HE VL+ +D E+ +L ++ ++E A
Sbjct: 1901 KALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAAR 1960
Query: 217 SRCRSLQEELYLLKQELQ--RANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKL 274
+R +LQE L LQ +++ EL + TA+ Q S D ++ E L
Sbjct: 1961 ARAEALQEALGKAHAALQGKEQHLLEQAELS-RSLEASTATLQASLDACQAHSRQLEEAL 2019
Query: 275 RSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQ 334
R + ++D+ Q ++ + +Q L +R LR + + + + ++ ++Q +
Sbjct: 2020 RIQEGEIQDQDLRYQ--EDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQ-E 2076
Query: 335 KSKMACQLYREKVNALQAQVCELQ----KERDQAYSARDSAQREISQSLV---EKDSLRR 387
K + + E++ L V ELQ ++ + R++ QR ++L + +
Sbjct: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136
Query: 388 QVFELTDQVCELRTQLRQLQAEPPGVLKQEARTRE 422
Q +L L+ +L +LQA +E RE
Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWRE 2171
Score = 45.4 bits (106), Expect = 3e-04
Identities = 68/307 (22%), Positives = 132/307 (42%), Gaps = 49/307 (15%)
Query: 135 LQEELNQEKGQKEVLLRRCQQ----LQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHE 190
+Q+EL +EK + L +Q LQE + + L Q + ++E+SA E
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM-E 1104
Query: 191 VLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQS 250
+LR + + A +EL AS Q L QE + A +L+L+ +S
Sbjct: 1105 LLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAA------QLQLRLRS 1158
Query: 251 LRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELV-------- 302
+ + + +++ + +L SL +L +Q+L SR EL
Sbjct: 1159 TESQLEALAAEQQPGNQAQAQAQLASLYSAL------QQALGSVCESRPELSGGGDSAPS 1212
Query: 303 --------ERIHSLRER-----AVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNA 349
SL +R A++AE + Q L + Q+++ + R++V
Sbjct: 1213 VWGLEPDQNGARSLFKRGPLLTALSAEAVASAL-HKLHQDLWKTQQTR---DVLRDQVQK 1268
Query: 350 LQAQVCELQKERDQAYSARDSAQREISQSLVEK-------DSLRRQVFELTDQVCELRTQ 402
L+ ++ + + E+ Q ++ QR++SQ+ EK +SL ++ EL + + L+++
Sbjct: 1269 LEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSR 1328
Query: 403 LRQLQAE 409
LR+ + +
Sbjct: 1329 LRRAELQ 1335
Score = 44.3 bits (103), Expect = 6e-04
Identities = 82/389 (21%), Positives = 145/389 (37%), Gaps = 88/389 (22%)
Query: 126 ECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLH------QLEADHSR 179
+ LAG LQ E++ ++E+L + ++L++ L + E A L QL+ D ++
Sbjct: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQ 504
Query: 180 -MKREVSAHFH----EVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQE-- 232
K E H E RL++ ++ L S +L E S E LL+QE
Sbjct: 505 GQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQT 564
Query: 233 -----LQRANMVSSCELELQEQSLRT-------------------ASDQESGDEELNRLK 268
L RA S EL E +L+T A D+ +++L +L+
Sbjct: 565 EVTAALARAEQ-SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLE 623
Query: 269 EENEKLRS-----------LTFSLAE---------------------------------- 283
EEN+ + S L LAE
Sbjct: 624 EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683
Query: 284 -----KDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKM 338
K+ +++ L E+R ++ ++ L + A E + +EKE + + ++
Sbjct: 684 DIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEV 743
Query: 339 ACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCE 398
Q L Q+ L ++ S+ AQ++ S V K L Q+ +T
Sbjct: 744 RLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEV 803
Query: 399 LRTQLRQLQAEPPGVLKQEARTREPCPRE 427
++ ++R L+ E Q + R+ R+
Sbjct: 804 IQGEVRCLKLELDTERSQAEQERDAAARQ 832
Score = 42.0 bits (97), Expect = 0.003
Identities = 60/285 (21%), Positives = 118/285 (41%), Gaps = 24/285 (8%)
Query: 128 LAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAH 187
L + L L Q + Q E + + L+E + + ET L + EA SR +E
Sbjct: 281 LQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS 340
Query: 188 FHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQ----ELQRANMVSSCE 243
+V+ KD + N Q + SL+ + + Q + +A +
Sbjct: 341 LQQVI--KDITQVMVEEGDNIAQ----GSGHENSLELDSSIFSQFDYQDADKALTLVRSV 394
Query: 244 LELQEQSLRTASDQESGDEE-LNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELV 302
L + Q+++ Q +G +E +N L++++++ E L Q L + G R L
Sbjct: 395 LTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEE------EGKALRQRLQKLTGERDTLA 448
Query: 303 ERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERD 362
+ L+ + ++RE + +E+ Q + + R +VN ELQ + D
Sbjct: 449 GQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR-RVNV------ELQLQGD 501
Query: 363 QAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQ 407
A ++ Q E+ ++ E++ L+ + L + E ++L L+
Sbjct: 502 SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR 546
Score = 32.7 bits (73), Expect = 1.8
Identities = 45/226 (19%), Positives = 99/226 (43%), Gaps = 19/226 (8%)
Query: 164 ETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSL----HYSNALQEKELAASRC 219
ETR+ GL+ ++ ++ E +VL L+ +M N+ + ++ A+
Sbjct: 2 ETRSPGLNNMKPQSLQLVLE-----EQVLALQQQMAENQAASWRKLKNSQEAQQRQATLV 56
Query: 220 RSLQEELYLLK---QELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRS 276
R LQ ++ + QEL++ + + + +++ ++ + DE L RL+EE ++ S
Sbjct: 57 RKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENV----EEPNLDELLVRLEEEQQRCES 112
Query: 277 LTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKS 336
L + + + D + +E VE++ RA ++E W+ +++ + K
Sbjct: 113 LAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKG 172
Query: 337 K--MACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLV 380
+ L+RE V + E++ D+ + +S SL+
Sbjct: 173 EHGRLLSLWREVV-TFRRHFLEMKSATDRDLMELKAEHVRLSGSLL 217
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 67.0 bits (162), Expect = 8e-11
Identities = 84/354 (23%), Positives = 156/354 (44%), Gaps = 22/354 (6%)
Query: 167 AEGLHQLEADHSRMKREVSAHFHEVLRLKDE-MLSLSLHYSNALQEKELAASRCRSLQEE 225
A +++ A +R ++E +A +RL+ E SL +E+ R R+ +EE
Sbjct: 286 ANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEE 345
Query: 226 LYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKD 285
L Q+LQ ELEL +++ R A L+EE E+ RS L +
Sbjct: 346 ELLRLQQLQEEKERKLQELELLQEAQRQAE---------RLLQEEEERRRSQHRELQQA- 395
Query: 286 ILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYRE 345
LE L EA +R + + L+E A +RQR + EE +Q L + + ++ + E
Sbjct: 396 -LEGQLREAEQARASMQAEME-LKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEE 453
Query: 346 KVNALQAQVCELQKER-DQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLR 404
V Q ++ E ++E+ Q ++ +R I ++ EK+ L++++ + + + + + QL
Sbjct: 454 SVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLE 513
Query: 405 QL----QAEPPGVLKQEARTREPCPREKQRLVR----MHAICPRDDSDCSLVSSTESQLL 456
++ Q V + + R+ K V+ MH I P D + S + Q
Sbjct: 514 EVRQNRQRADEDVEAAQRKLRQASTNVKHWNVQMNRLMHPIEPGDKRPVTSSSFSGFQPP 573
Query: 457 SDLSATSSRELVDSFRSSSPAPPSQQSLYKRVAEDFGEEPWSFSSCLEIPEGDP 510
SS + + + S PS S ++ + + G+E + +S + + DP
Sbjct: 574 LLAHRDSSLKRLTRWGSQGNRTPSPNSNEQQKSLNGGDEAPAPASTPQEDKLDP 627
Score = 34.3 bits (77), Expect = 0.60
Identities = 37/140 (26%), Positives = 68/140 (48%), Gaps = 15/140 (10%)
Query: 136 QEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLK 195
+EE +++ + + L Q+LQE L L + +R+ E ++++LK
Sbjct: 418 EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLK 477
Query: 196 DEMLSLSLHYSNALQEKE----LAASRCRSL---QEELYLLKQELQRANMVSSCELELQE 248
+E + A QEKE A + RSL Q++L ++Q QRA+ ++E +
Sbjct: 478 EEQ---ERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADE----DVEAAQ 530
Query: 249 QSLRTAS-DQESGDEELNRL 267
+ LR AS + + + ++NRL
Sbjct: 531 RKLRQASTNVKHWNVQMNRL 550
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 66.6 bits (161), Expect = 1e-10
Identities = 91/368 (24%), Positives = 159/368 (43%), Gaps = 54/368 (14%)
Query: 120 ETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSR 179
E +K + A +G LQE LN+ L + Q + L L+E +A+ L +L A +
Sbjct: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
Query: 180 MKREVSAHFHEVLRLKD----EMLSLSLHYSNALQEKELAAS--------RCRSLQEELY 227
+ +S + L+L+ E S L +A EK L + R QE+L+
Sbjct: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
Query: 228 LLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDIL 287
+QE+ +S EL+ +R +E D E R ++ E SL + E + +
Sbjct: 392 QTRQEM------TSMSAELK---MRAIQAEERLDMEKRRCRQSLEDSESL--RIKEVEHM 440
Query: 288 EQSLDEARGSRQELVERIHSLR-ERAVAAERQREQYWEEKEQTLLQFQKSKMACQL-YRE 345
+ L+E+ + QE V+R+ + R R + E+ Q + K+K +L ++
Sbjct: 441 TRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQ 500
Query: 346 KVNALQAQVCELQKERDQAYSA-------RDSAQREISQSLVEKDSLRRQVFELTDQV-- 396
++ L+ ++ L + RD+A A AQ +SQ ++ + LRR++ EL ++
Sbjct: 501 RLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
Query: 397 -------------CELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLV----RMHAICP 439
EL+ Q +LQAE + QEA + E+Q V A+
Sbjct: 561 KDQERVAEVSRVRVELQEQNGRLQAE---LAAQEALREKAAALERQLKVMASDHREALLD 617
Query: 440 RDDSDCSL 447
R+ + SL
Sbjct: 618 RESENASL 625
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 65.5 bits (158), Expect = 2e-10
Identities = 97/444 (21%), Positives = 190/444 (42%), Gaps = 72/444 (16%)
Query: 38 RLTPYLRQAKVLCQLDEEEVLHSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFHNP 97
++ P LR A+ EEE+ +A+RA + RG GA+A E+ +
Sbjct: 884 KMKPLLRSAQA-----EEEL--------AALRA-------ELRGLRGALAAAEAKRQELE 923
Query: 98 DVYTLVT------GLQPDVDFSNFSGLMETSKLT----ECLAGAIGSLQEELNQEK---- 143
+ + +T LQ + N + E L L G + L E L E+
Sbjct: 924 ETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNA 983
Query: 144 ---GQKEVLLRRCQQLQEHLG-LAETRAEGLHQLEADHSRMKR---EVSAHFHEVLRLKD 196
++ L C +L++ + L T A+ + +A +++K E++A V RL
Sbjct: 984 DLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTK 1043
Query: 197 EMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQ-----------------RANMV 239
E +L + AL + + R +L + L+Q+++ RA
Sbjct: 1044 EKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRK 1103
Query: 240 SSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDIL----EQSLDEAR 295
+L+L ++S+ A+ + EE +LK+++ +L L+ + ++ +L ++ + E +
Sbjct: 1104 LEGDLKLTQESVADAAQDKQQLEE--KLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQ 1161
Query: 296 GSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVC 355
+EL E + + R E+QR + E E+ + +++ A RE +A++
Sbjct: 1162 ARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELG 1221
Query: 356 ELQKERDQA-------YSARDSAQREISQSLVEK-DSLRRQVFELTDQVCELRTQLRQLQ 407
L++E ++A +A Q E + L E+ DSL+R +L + ELR ++ L
Sbjct: 1222 RLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLA 1281
Query: 408 AEPPGVLKQEARTREPCPREKQRL 431
A + + +A + C + +L
Sbjct: 1282 ANVETLTRAKASAEKLCRTYEDQL 1305
Score = 55.1 bits (131), Expect = 3e-07
Identities = 91/416 (21%), Positives = 172/416 (41%), Gaps = 60/416 (14%)
Query: 81 GKNGAIAFLESLKFHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELN 140
G A+ LE+LK N ++ ++ L V S S + E K + L G +Q L
Sbjct: 1536 GHEEALEALETLKRENKNLQEEISDLTDQVSLSGKS-IQELEKTKKALEGEKSEIQAALE 1594
Query: 141 QEKGQKEVLLRRCQQLQEHLGLAETRAE----------GLHQLEADHSRMKREVSAHF-- 188
+ +G E L + L+ L L++ +AE L +H R + A
Sbjct: 1595 EAEGALE--LEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDA 1652
Query: 189 -----HEVLRLKDEMLS----LSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMV 239
+E LRLK +M L L +A ++ A + R +Q +L K+E +
Sbjct: 1653 ETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQL---KEEQAGRDEE 1709
Query: 240 SSCELELQEQSL---RTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARG 296
EL EQ+ R AS + EEL E+ E+ R L AE+++LE +
Sbjct: 1710 QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRL----AEQELLEAT------ 1759
Query: 297 SRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVN------AL 350
ER++ L + Q+++ + Q + +++ + EK A+
Sbjct: 1760 ------ERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAM 1813
Query: 351 QAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELT-----DQVCELRTQLRQ 405
A+ EL+KE+D + + + ++ + Q++ E + + + QV +L ++R+
Sbjct: 1814 MAE--ELKKEQDTS-AHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRE 1870
Query: 406 LQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSA 461
L+AE K+ A + + ++R+ + D + + + +L S + +
Sbjct: 1871 LEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKS 1926
Score = 47.8 bits (112), Expect = 5e-05
Identities = 62/296 (20%), Positives = 125/296 (42%), Gaps = 24/296 (8%)
Query: 131 AIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHE 190
A+ SLQ L+ E + LR ++++ L E + + + R + A E
Sbjct: 1642 AVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKE 1701
Query: 191 VLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQS 250
+DE L+ Q E AS + EEL ++ +R+ ++ EL +
Sbjct: 1702 EQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATER 1761
Query: 251 LRTASDQESGDEELNRLKEENEKLRSLTFSLAE--------KDILEQSLDEARGSRQEL- 301
L Q +G LN+ K+ L L+ + E ++ ++++ +A +EL
Sbjct: 1762 LNLLHSQNTG--LLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELK 1819
Query: 302 --------VERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQ 353
+ER+ E+ V R+ + EE EQ L+ K ++ Q KV L+A+
Sbjct: 1820 KEQDTSAHLERMKKTLEQTV---RELQARLEEAEQAALRGGKKQV--QKLEAKVRELEAE 1874
Query: 354 VCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAE 409
+ QK+ +A +R + + + + R+ + + D V +L+++++ + +
Sbjct: 1875 LDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQ 1930
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 64.7 bits (156), Expect = 4e-10
Identities = 106/428 (24%), Positives = 168/428 (39%), Gaps = 58/428 (13%)
Query: 583 ISVIGGNLTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGL 642
+ + GGN GIF+ V GS AD ++ G QI+ V+ ++ T EEAV
Sbjct: 427 LRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVN--------DVPFQNLTREEAVQF 478
Query: 643 LRRVDGFCCLSVKVNTDGYKRLLQDLEAKVATS--GDSFYIRVNLAMEGRAKGELQVHCN 700
L L + + QD+ K+ S GDSFYIR + +E L
Sbjct: 479 LLG------LPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRG 532
Query: 701 EVLHVTDTMFQGCGCWHAHRVNSYTMK-----DTAAHGTIPNYSRAQQQLIALIQDMTQQ 755
+V HV DT+ G G HA + ++ G IPN SRA +QL +L + Q+
Sbjct: 533 DVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRA-EQLASL--EAAQR 589
Query: 756 CTVTRKPSSGGPQKLVRIVSMDKAKASPLRLSFDRGQLDPSRMEGSSTCFWAESCLTLVP 815
SS G + + + + R + D S + P
Sbjct: 590 AVGVGPGSSAGSNARAEFWRLRGLRRGAKKTT-QRSREDLSALTRQG---------RYPP 639
Query: 816 YTLVWPHRPARPRPVLLVPRAVGKILSEKLCLLQGFKKCLAEYLSQEEYEAWSQRGDIIQ 875
Y V + RPV+++ V I +KL AE Q E R D
Sbjct: 640 YERVVLREASFKRPVVIL-GPVADIAMQKL---------TAEMPDQFEIAETVSRTDSPS 689
Query: 876 EGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNEKMA-KK 934
+ + V + EK+ HALLDV ++ L+ + +PIV+ + A K
Sbjct: 690 K--------IIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKA 741
Query: 935 LKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAP-DGWSDLDGLLSCVRQAIADEQ 993
L++ L + L A Q+ + L+++ P +G SD ++ I ++Q
Sbjct: 742 LRQWLAPASRRSTRRLYAQAQKL--RKHSSHLFTATIPLNGTSDT--WYQELKAIIREQQ 797
Query: 994 KKVVWTEQ 1001
+ +WT +
Sbjct: 798 TRPIWTAE 805
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 64.7 bits (156), Expect = 4e-10
Identities = 67/332 (20%), Positives = 132/332 (39%), Gaps = 23/332 (6%)
Query: 136 QEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLK 195
QE L + Q E L++ QL+ + R E ++ ++ + R++ E LK
Sbjct: 907 QETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLE---DECFELK 963
Query: 196 DEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTAS 255
E+ L + +EK + ++L EE+ L +++ + N + E +Q+L
Sbjct: 964 KEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTL---D 1020
Query: 256 DQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAA 315
D +E+L+ L + N KL + D LE +L++ R +R +H L
Sbjct: 1021 DLHMEEEKLSSLSKANLKLEQ------QVDELEGALEQERKARMNCERELHKLEGNLKLN 1074
Query: 316 ERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREI 375
E + + +K ++ KV + V +LQK + + + ++
Sbjct: 1075 RESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKL 1134
Query: 376 SQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMH 435
+ + R+ +LT + +L +L ++ L E +++ + ++H
Sbjct: 1135 EAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQL-------EITKKQETKFQKLH 1187
Query: 436 AICPRDDSDCSLVSSTESQLLSDLSATSSREL 467
RD + +L T S L A S EL
Sbjct: 1188 ----RDMEEATLHFETTSASLKKRHADSLAEL 1215
Score = 55.5 bits (132), Expect = 3e-07
Identities = 61/286 (21%), Positives = 127/286 (44%), Gaps = 20/286 (6%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGL----HQLEADHSRMKREVSAHFHE 190
+Q + E +KE+ +R Q+ E +G+A R L HQL+ + ++
Sbjct: 1392 IQRTEDLEDAKKELAIR-LQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSA 1450
Query: 191 VLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQS 250
RL + L ++ Q+ E + + + Q+E+ L EL + + QE
Sbjct: 1451 AARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETL 1510
Query: 251 LRTASD-QESGDEELNRLKE------ENEKLRSLTFSLAEKDILEQSLDEARGSRQELVE 303
R + QE N+++E E EK++ L EK ++ +L+E G+ +
Sbjct: 1511 RRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEE--EKTEVQVTLEETEGALERNES 1568
Query: 304 RIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQ 363
+I + + A+ + E+ EK++ + F++ K C +++LQ+ + K R +
Sbjct: 1569 KILHFQLELLEAKAELERKLSEKDEEIENFRR-KQQC-----TIDSLQSSLDSEAKSRIE 1622
Query: 364 AYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAE 409
+ + ++++ ++ RQV E T + +L+ Q++ LQ +
Sbjct: 1623 VTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQ 1668
Score = 48.9 bits (115), Expect = 2e-05
Identities = 63/291 (21%), Positives = 124/291 (42%), Gaps = 30/291 (10%)
Query: 132 IGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEV 191
I SLQ L+ E + + R ++++E L E + ++ ++ ++ ++ ++
Sbjct: 1606 IDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDL 1665
Query: 192 LRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCEL-ELQE-- 248
D+ L+ + E S +S E+L L+++ +R +S EL E E
Sbjct: 1666 QMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERI 1725
Query: 249 -----QSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVE 303
Q+ S ++ + ++ R+++E E++ + E E+ +A L E
Sbjct: 1726 NLFYTQNTSLLSQKKKLEADVARMQKEAEEV------VQECQNAEEKAKKAAIEAANLSE 1779
Query: 304 RIHSLRERAVAAERQREQYWEEKEQTLLQFQK-----SKMACQLYREKVNALQAQVCELQ 358
+ ++ ER RE EQT+ QK +MA R+++ L+++V EL+
Sbjct: 1780 ELKKKQDTIAHLERTRENM----EQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELE 1835
Query: 359 KERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAE 409
E + AQR + L R + ELT Q E + L ++Q +
Sbjct: 1836 GELEGEIRRSAEAQRGARR-------LERCIKELTYQAEEDKKNLSRMQTQ 1879
Score = 45.8 bits (107), Expect = 2e-04
Identities = 60/293 (20%), Positives = 116/293 (39%), Gaps = 34/293 (11%)
Query: 137 EELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKD 196
E++ + K E L C +E L A + + + QL D + K ++ + E LR +
Sbjct: 1248 EQMTRAKANAEKL---CTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLE 1304
Query: 197 E----MLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLR 252
E + LS SN ++ E + + L LQ+A E E+
Sbjct: 1305 EKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQE 1364
Query: 253 TASDQESGDEELN------RLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIH 306
++ ++N R+K EN ++ + LE + E QE E +
Sbjct: 1365 VKAELHRTLSKVNAEMVQWRMKYENNVIQ-------RTEDLEDAKKELAIRLQEAAEAMG 1417
Query: 307 SLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYS 366
R + ER R Q E L K + A +K + + +++ +++ +
Sbjct: 1418 VANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQA 1477
Query: 367 ARDSAQREIS--------------QSLVEKDSLRRQVFELTDQVCELRTQLRQ 405
D++Q+E+ +S+V +++LRR+ L +++ L Q+R+
Sbjct: 1478 LLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVRE 1530
Score = 40.0 bits (92), Expect = 0.011
Identities = 69/319 (21%), Positives = 129/319 (40%), Gaps = 45/319 (14%)
Query: 118 LMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADH 177
L SK L + L+ L QE+ + R +L+ +L L E + LE+
Sbjct: 1029 LSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKL---NRESMENLESSQ 1085
Query: 178 SRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAAS---RCRSLQEELYLLKQELQ 234
H E LR K+ L LS S EK L A + LQ ++ LK++L+
Sbjct: 1086 R--------HLAEELRKKE--LELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLE 1135
Query: 235 RANMVSSCELELQEQSL-RTASD-----QESGDEELNRL---KEENEKLRSLTFSLAEKD 285
A + ++E + L + +D +E G L +L K++ K + L + E
Sbjct: 1136 -AERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEAT 1194
Query: 286 ILEQSLDEARGSRQ-----ELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMA- 339
+ ++ + R EL ++ +L++ E+ + E + L + ++ A
Sbjct: 1195 LHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAK 1254
Query: 340 ------CQLYREKVNALQAQV-------CELQKERDQAYSARDSAQREISQSLVEKDSLR 386
C LY E+++ A++ +L ++ + +S R + + + L
Sbjct: 1255 ANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLS 1314
Query: 387 RQVFELTDQVCELRTQLRQ 405
R+ T Q+ +LR QL +
Sbjct: 1315 REKSNFTRQIEDLRGQLEK 1333
Score = 38.9 bits (89), Expect = 0.025
Identities = 46/227 (20%), Positives = 100/227 (44%), Gaps = 27/227 (11%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRL 194
L+ ++ + + + E +++ CQ +E A A L ++ + K++ AH R
Sbjct: 1742 LEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANL----SEELKKKQDTIAHLE---RT 1794
Query: 195 KDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRA-NMVSSCELELQEQSLRT 253
++ M L E E Q L ++++Q+ + V E EL E +R
Sbjct: 1795 RENMEQTITDLQKRLAEAE---------QMALMGSRKQIQKLESRVRELEGEL-EGEIRR 1844
Query: 254 ASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAV 313
+++ + G L R ++ LT+ AE+D +++L + +L ++ + +++
Sbjct: 1845 SAEAQRGARRLERC------IKELTYQ-AEED--KKNLSRMQTQMDKLQLKVQNYKQQVE 1895
Query: 314 AAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKE 360
AE Q QY + ++ + + K ++ +VN L+ + E K+
Sbjct: 1896 VAETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKK 1942
Score = 37.7 bits (86), Expect = 0.055
Identities = 74/302 (24%), Positives = 119/302 (39%), Gaps = 66/302 (21%)
Query: 190 EVLRLKDEMLSLSLHYSNA-LQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQE 248
EV LK+E L + Q +EL A + QE+ L+ Q +++ E E E
Sbjct: 860 EVAGLKEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVE-EQCE 918
Query: 249 QSLRTASDQESGDEELNRLKEENE-----------KLRSLTFSL-AEKDILEQSLDEARG 296
+++ E+ +EL+ EE E KL F L E D LE L ++
Sbjct: 919 WLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEK 978
Query: 297 SR-------QELVERIHSLRERAVAAERQREQYWEEKEQTL--LQFQKSKMACQLYREKV 347
+ + L E + L E R + E +QTL L ++ K++ K
Sbjct: 979 EKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSS---LSKA 1035
Query: 348 N-ALQAQVCELQKERDQAYSAR------------------------DSAQREISQSLVEK 382
N L+ QV EL+ +Q AR +S+QR +++ L +K
Sbjct: 1036 NLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKK 1095
Query: 383 DSLRRQ-----------VFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRL 431
+ Q V +L V EL+TQ++ L+ + L+ E TR RE+ L
Sbjct: 1096 ELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEK----LEAERTTRAKMERERADL 1151
Query: 432 VR 433
+
Sbjct: 1152 TQ 1153
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 64.3 bits (155), Expect = 5e-10
Identities = 67/314 (21%), Positives = 149/314 (47%), Gaps = 37/314 (11%)
Query: 134 SLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVS-AHFHEVL 192
+L EL + E L ++ +LQE L LAE+ +++ + +KR++ A F
Sbjct: 208 ALSLELYRNTITNEELKKKNAELQEKLPLAESEKS---EIQLNVKELKRKLERAKF---- 260
Query: 193 RLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLR 252
L ++ + +L QE+EL + ++E + +QE + L+EQ +
Sbjct: 261 -LLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER-----------LREQEGK 308
Query: 253 TASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERA 312
+E + RL+E+ ++LR L E+ L + ++ + +++ E+ +RE+
Sbjct: 309 MREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQE 368
Query: 313 VAAERQREQYWEEKEQTLLQFQKSKMACQLYR-----EKVNALQAQVCELQKERDQAYSA 367
RQ E+ WE+++Q ++ Q+ KM Q R E++ + ++ E +K +Q
Sbjct: 369 EKMWRQEERLWEQEKQ--MREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKM 426
Query: 368 RDSAQ--------REISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEAR 419
R+ + R+ + + E++ +R + ++ ++ +R Q ++Q + + +QE +
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEK 486
Query: 420 --TREPCPREKQRL 431
++ P +K++L
Sbjct: 487 EWQQQRLPEQKEKL 500
Score = 50.4 bits (119), Expect = 8e-06
Identities = 63/341 (18%), Positives = 151/341 (44%), Gaps = 32/341 (9%)
Query: 119 METSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEA--- 175
++T+ L E + L+E+ + + Q+E + R+ ++L+E G + E + + E
Sbjct: 265 VQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLR 324
Query: 176 DHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQEL-Q 234
+ + RE E L+++ + +++E + R +E+++ ++ L +
Sbjct: 325 EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEE----KMREQEEKMWRQEERLWE 380
Query: 235 RANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSL--- 291
+ + E ++++Q R E E+ R++E+ + + EK + EQ
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440
Query: 292 ---------DEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQL 342
+ R +++ E ++RE+ ++Q E WE++E+ Q + + +L
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 500
Query: 343 Y-REKVNALQAQVCEL-QKERDQAYS--------ARDSAQREISQSLVEKDSLRRQVFEL 392
+ +EK+ + ++ E +K RDQ ++ + + Q +++ +R Q ++
Sbjct: 501 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 393 TDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVR 433
DQ E R + + + E ++E E RE+++ +R
Sbjct: 561 WDQ--EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR 599
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/294 (19%), Positives = 127/294 (43%), Gaps = 34/294 (11%)
Query: 136 QEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLK 195
QEE E+ +KE +R + +E L E E + E E +R +
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE------------QEEKIWEQEEKIRDQ 523
Query: 196 DEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTAS 255
+EM +++++ + ++E + QE + + E + QEQ +T
Sbjct: 524 EEMWGQE---KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTW- 579
Query: 256 DQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAA 315
DQE E R++E +K+R E++++ + ++ + +++ E+ + E+
Sbjct: 580 DQEEKMREEERMREREKKMRE------EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKM 633
Query: 316 ERQREQYWEEK-----------EQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQA 364
+ Q E+ WE++ EQ L QK K+ ++ +Q Q ++ ++
Sbjct: 634 QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKME 693
Query: 365 YSARDSAQREISQ-SLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQE 417
++ ++ Q + E++S+R + ++ ++ +R Q ++Q + + +QE
Sbjct: 694 KKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 747
Score = 41.6 bits (96), Expect = 0.004
Identities = 46/226 (20%), Positives = 107/226 (47%), Gaps = 36/226 (15%)
Query: 209 LQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLK 268
++E+E R + ++EE +++++ E ++QEQ + +E E+ +++
Sbjct: 585 MREEERMREREKKMREEEEMMREQ----------EEKMQEQEEKMQEQEEKMWEQEEKMQ 634
Query: 269 EENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQ 328
E+ EK+ E+ + EQ +E +Q L E+ L E E+++ Q EEK
Sbjct: 635 EQEEKMWE-----QEEKMWEQ--EEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK-- 685
Query: 329 TLLQFQKSKMACQLYREKVNALQAQVCELQKER-DQAYSARDSAQREISQSLVEKDSLRR 387
+++ KM +K + + + +K R +++ R+ RE E++ +R
Sbjct: 686 ---IWEQEKM-----EKKTQEQEKKTWDQEKMREEESMREREKKMRE------EEEMMRE 731
Query: 388 QVFELTDQVCELRTQLRQLQAEPPGVLKQEAR--TREPCPREKQRL 431
Q ++ +Q +++ Q ++ + + +QE + ++ P +K++L
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
Score = 37.7 bits (86), Expect = 0.055
Identities = 48/298 (16%), Positives = 133/298 (44%), Gaps = 26/298 (8%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRL 194
++E + + ++E++ + +++QE + + E + + E + ++ ++
Sbjct: 591 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ 650
Query: 195 KDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTA 254
+++M L E++ +QE+ + +QE ++ E + QEQ +T
Sbjct: 651 EEKMWE-----QQRLPEQKEKLWEHEKMQEQEKMQEQE-EKIWEQEKMEKKTQEQEKKTW 704
Query: 255 SDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVA 314
++ +EE ++E +K+R E++++ + ++ + +++ E+ + E
Sbjct: 705 DQEKMREEE--SMREREKKMRE------EEEMMREQEEKMQEQEEKMQEQEEEMWE---- 752
Query: 315 AERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCEL-QKERDQAYSARDSAQR 373
Q E+ WE++E+ Q + + +L+ + Q ++ E +K RDQ R ++
Sbjct: 753 ---QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEK 809
Query: 374 EISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRL 431
Q ++ +R Q ++ Q ++ Q ++ + + QE + E +++++
Sbjct: 810 MRGQ----EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKM 863
Score = 34.7 bits (78), Expect = 0.46
Identities = 49/260 (18%), Positives = 107/260 (41%), Gaps = 20/260 (7%)
Query: 136 QEELNQEKGQK-----EVLLRRCQQLQEHLGLAETRAE--GLHQLEADHSRMKREVSAHF 188
QEE QE+ +K E + + +++ E L E + + +++ ++E
Sbjct: 629 QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWE 688
Query: 189 HEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQE 248
E + K + ++E+E R + ++EE +++++ ++ E +E
Sbjct: 689 QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Query: 249 QSLRTAS---DQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSL------DEARGSRQ 299
+ +QE E RL E+ EKL ++ I EQ ++ RG +
Sbjct: 749 EMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEE 808
Query: 300 ELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQK 359
++ + +R + Q E+ W ++E+ + Q+ KM Q EK+ E +
Sbjct: 809 KMRGQEEKMRGQEEKMWGQEEKMWGQEEK--MWGQEEKMWGQ--EEKMEEKMQGQEEKMR 864
Query: 360 ERDQAYSARDSAQREISQSL 379
E+++ ++ RE + +
Sbjct: 865 EQEEKMRGQEEKMREQEEKM 884
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 64.3 bits (155), Expect = 5e-10
Identities = 69/287 (24%), Positives = 134/287 (46%), Gaps = 21/287 (7%)
Query: 149 LLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNA 208
L + Q+L+E L E+R E + K+++ AH ++ +E L
Sbjct: 913 LAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDL----EEQLDEEEGARQK 968
Query: 209 LQ-EKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEE---- 263
LQ EK A ++ + ++EE+ LL+ + N E +L E + S Q + +EE
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQ----NSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 264 LNRLKEENEKLRS-LTFSLAEKDILEQSLDEAR----GSRQELVERIHSLRERAVAAERQ 318
L +++ + E + S L L +++ Q L++A+ G +L ++I L+ + + Q
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 319 REQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQS 378
+ EE + L + + + V LQAQ+ ELQ++ + ++R+ A+++
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144
Query: 379 LVEKDSLRRQVFELTDQVC---ELRTQLRQLQAEPPGVLKQEARTRE 422
E ++L+ ++ + D ELRT+ Q AE L++E + E
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Score = 54.7 bits (130), Expect = 4e-07
Identities = 58/290 (20%), Positives = 124/290 (42%), Gaps = 16/290 (5%)
Query: 120 ETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSR 179
E K L + Q EL + + ++ + + ++ ++ L E L + A R
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Query: 180 MKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRAN-M 238
+R E L DE+ + + S L EK +R L+EEL + ++ N
Sbjct: 1702 ARRHAEQERDE---LADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDR 1758
Query: 239 VSSCELELQEQSLRTASDQ---ESGDEELNRLKEENEKLRSLTFSL--AEKDILEQSLDE 293
L++ + A+++ + D +L+ +N++L++ L A K + ++
Sbjct: 1759 FRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISA 1818
Query: 294 ARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYRE---KVNA- 349
+L E++ + AA + + ++ ++ +Q + + Y+E K NA
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR 1878
Query: 350 ---LQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQV 396
L+ Q+ E ++E +A ++R QRE+ + + L R+V L +++
Sbjct: 1879 MKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRL 1928
Score = 49.7 bits (117), Expect = 1e-05
Identities = 63/318 (19%), Positives = 125/318 (39%), Gaps = 31/318 (9%)
Query: 123 KLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKR 182
K+ L I LQE+ EK + ++ + L E L +T E A ++
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 183 EVSAHFHEVLRLKDE--------MLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQ 234
+ E+ + +E + + ++ AL+E + + + L KQ L+
Sbjct: 1171 KREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230
Query: 235 RANMVSSCELE-LQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEK-DILEQSLD 292
N +CE++ LQ+ + ++ D ++ L + + L LAEK L+ LD
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 293 EARGSRQELVERIHSLRERAVAAERQRE---------------------QYWEEKEQTLL 331
+E ++ + A + E Q + Q EEK
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 332 QFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFE 391
Q ++ + A + ++V ALQ+Q+ + +K+ D +S + + L + ++L +++ E
Sbjct: 1351 QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEE 1410
Query: 392 LTDQVCELRTQLRQLQAE 409
+L +LQ E
Sbjct: 1411 KALAYDKLEKTKNRLQQE 1428
Score = 48.9 bits (115), Expect = 2e-05
Identities = 73/355 (20%), Positives = 143/355 (40%), Gaps = 77/355 (21%)
Query: 116 SGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQ--- 172
S L +T K + G I SL+E + E L +R ++ E L Q
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 173 ---LEADHSRMKREVSAHFHEVLRLKDEML----SLSLHYSNALQEKELAASRCRSLQEE 225
++ DH +R+V+++ + + D++L S+S Y+ +E++ A + R + +
Sbjct: 1431 DLTVDLDH---QRQVASNLEKKQKKFDQLLAEEKSISARYA---EERDRAEAEAREKETK 1484
Query: 226 LYLLKQELQRANMVSSCELELQEQSLRT-ASDQESGDEELNRLKEENEKLRSLTFSLAEK 284
L + L+ A + + E E Q + LR D S +++ + E EK K
Sbjct: 1485 ALSLARALEEA-LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK---------SK 1534
Query: 285 DILEQSLDEARGSRQELVERIHSLRERAVAAE--------------RQREQYWEEKEQTL 330
LEQ ++E R +EL + + + + + E + R++ EEK++ L
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 331 LQ--------------------FQKSKMACQLYR----------------EKVNALQAQV 354
++ K KM L +++ LQAQ+
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQM 1654
Query: 355 CELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAE 409
+ Q+E ++A ++RD + +S + SL ++ +L +++ R + E
Sbjct: 1655 KDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQE 1709
Score = 44.3 bits (103), Expect = 6e-04
Identities = 63/287 (21%), Positives = 121/287 (42%), Gaps = 33/287 (11%)
Query: 136 QEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLK 195
++E N+EK K +L+++ ++L+ AE E + A S+ K E+ LK
Sbjct: 1583 RDEQNEEK--KRLLIKQVRELE-----AELEDERKQRALAVASKKKMEID--------LK 1627
Query: 196 DEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTAS 255
D L A + ++ + R LQ ++ ++EL+ A E+ QS +
Sbjct: 1628 D----LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRD---EIFAQSKESEK 1680
Query: 256 DQESGDEELNRLKEE-NEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVA 314
+S + E+ +L+EE R+ + E+D L + + + L++ L R
Sbjct: 1681 KLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIA- 1739
Query: 315 AERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQRE 374
Q E+ EE++ + L + +NA A ++ D A + +E
Sbjct: 1740 ---QLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796
Query: 375 ISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTR 421
+ L E + + F+ T + L ++ QL+ + L+QEA+ R
Sbjct: 1797 LKAKLQELEGAVKSKFKAT--ISALEAKIGQLEEQ----LEQEAKER 1837
Score = 43.1 bits (100), Expect = 0.001
Identities = 50/219 (22%), Positives = 95/219 (43%), Gaps = 40/219 (18%)
Query: 249 QSLRTASDQESGDEELNRLKEENEKL--------RSLTFSLAEKDILEQSLDEARGSRQE 300
Q R + ++ DEEL ++KE+ K+ R L EK+IL + L + E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ----AETE 901
Query: 301 LVERIHSLRERAVAAERQREQYW---------EEKEQTLLQFQKSKMACQL--YREKVNA 349
L +R R A +++ E+ EE+ +LQ +K KM + E+++
Sbjct: 902 LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDE 961
Query: 350 LQAQVCELQKERDQAYSARDSAQREI-------SQSLVEKDSLRRQVFELTDQVCE---- 398
+ +LQ E+ A + + EI S+ + EK + ++ E + Q+ E
Sbjct: 962 EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 399 ------LRTQLRQLQAEPPGVLKQEARTREPCPREKQRL 431
+R + + ++ LK+E +TR+ + K++L
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKL 1060
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 63.9 bits (154), Expect = 7e-10
Identities = 80/326 (24%), Positives = 147/326 (45%), Gaps = 29/326 (8%)
Query: 126 ECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLG---LAETRAEGLHQLEADHSRMKR 182
E L G + L+E L+Q + Q+ E LG ET + L A++++++
Sbjct: 381 EILQGKLSQLEEHLSQLQDNPP------QEKGEVLGDVLQLETLKQEAATLAANNTQLQA 434
Query: 183 EVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSC 242
V E + + ++L+ H+ Q+ + +S L K+EL++A+
Sbjct: 435 RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA 494
Query: 243 ELELQEQSLRTA-----SDQESGDEELNRLKEE-NEKLRSLTFSLAEKDILEQSL----D 292
L Q SL + + + D+EL LK++ EK L +L +++ Q L +
Sbjct: 495 RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554
Query: 293 EARGSRQELVERIHSLRERAVAAERQREQYW----EEKEQTLLQFQKS-KMACQLYREKV 347
+ S ++ +++ + E+ A + Q EE+E +L + + K L +EK
Sbjct: 555 QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614
Query: 348 NALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQ 407
L+ LQ++ A ARDSAQ ++Q+ EK L R+V EL V R + + Q
Sbjct: 615 AKLEI----LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQ 670
Query: 408 AEPPGVLKQEARTREPCPREKQRLVR 433
A+ L+ + R+ + EK+R+ +
Sbjct: 671 AQ-VAELELQLRSEQQKATEKERVAQ 695
Score = 55.5 bits (132), Expect = 3e-07
Identities = 77/312 (24%), Positives = 133/312 (42%), Gaps = 42/312 (13%)
Query: 137 EELNQEKGQK-EVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLK 195
E L +EK K E+L ++ Q E A+T + +A+ SR E+ A + +
Sbjct: 607 EALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ 666
Query: 196 DE----MLSLSLHYSNALQ---EKELAASRCRSLQEELYLLKQEL------------QRA 236
E + L L + Q EKE A LQE+L LK+ L + A
Sbjct: 667 HEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAA 726
Query: 237 NMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSL--------AEKDILE 288
+ + + + E T S E E L+EE + L L AE ++L
Sbjct: 727 DALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLR 786
Query: 289 QSLDEARGSR-------QELVERIHSLRERAVAAERQREQY---WEEKEQTLL-QFQKSK 337
+ L EA ++ ++LV+ + + RER ++++ QY ++E+ TL + +K++
Sbjct: 787 RELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKAR 846
Query: 338 MACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVC 397
Q +EKV +++ ELQ R Q A A + V++ +R Q +L D +
Sbjct: 847 QELQEAKEKVAGIESH-SELQISRQQNELAELHANLARALQQVQEKEVRAQ--KLADDLS 903
Query: 398 ELRTQLRQLQAE 409
L+ ++ E
Sbjct: 904 TLQEKMAATSKE 915
Score = 50.8 bits (120), Expect = 6e-06
Identities = 117/487 (24%), Positives = 189/487 (38%), Gaps = 65/487 (13%)
Query: 131 AIGSLQEELNQEKGQKEVLL---RRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAH 187
A+ +LQ E + LL CQQLQ AE R H+ E + S K+
Sbjct: 1342 ALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKR----HREELEQS--KQAAGGL 1395
Query: 188 FHEVLRLKDEMLSLSLHYSNALQEKELAASRCR----SLQEELYLLKQE---LQRANMVS 240
E+LR + E+ L + + E+E A + R S E+L +LK+ L N
Sbjct: 1396 RAELLRAQRELGEL-IPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGL 1454
Query: 241 SCELELQEQSLRTASDQ--ESGDEELNRLKEENEKL-----RSLTFSLAEKDILEQSLDE 293
L Q L DQ E +EL ++ + E R + E +++ +
Sbjct: 1455 GERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514
Query: 294 ARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQK----SKMACQLYREKVNA 349
A+ E +R R++ A Q E + E+ + + + K S A ++ ++K+ A
Sbjct: 1515 AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574
Query: 350 LQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFEL-------TDQVCELRTQ 402
+QAQ E Q+E + + + Q ++SQ + + Q+ + Q EL+ Q
Sbjct: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634
Query: 403 LRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDC----SLVSSTESQL--- 455
LR L+ + K+ R R L + + C + V S E+Q+
Sbjct: 1635 LRSLEQ----LQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHA 1690
Query: 456 ---LSDLSATSSRELVDSFRSSSPAPPSQQSLYKRVAEDFGEE--PWSFSSCLEIPEGDP 510
L DL + D+ +S P Q L + EE P S +S L + D
Sbjct: 1691 DQQLRDLG--KFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDG 1748
Query: 511 GALPGAKAG------DPHLD-YELLDTADLP-----QLESSLQPVSPGRLDVSESGVLMR 558
++PG A P ++ E L +P LESSL + LD R
Sbjct: 1749 TSVPGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSAR 1808
Query: 559 RRPARRI 565
RR + I
Sbjct: 1809 RRTTQII 1815
Score = 47.8 bits (112), Expect = 5e-05
Identities = 96/436 (22%), Positives = 180/436 (41%), Gaps = 73/436 (16%)
Query: 128 LAGAIGSLQEEL---NQEKGQKEVLLRRCQQLQEHLG-----------------LAETRA 167
LA + +LQE++ ++E + E L+R+ + QE L E +
Sbjct: 898 LADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG 957
Query: 168 EGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLS--LHYSNALQEKELAA---SRCRSL 222
+A M+RE +E+ RL+ ++ QE+E+A R R+
Sbjct: 958 RQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRA- 1016
Query: 223 QEELYLLKQ-----ELQRANMVSSCELE---LQEQSLRTASDQESGDEELNRLK------ 268
Q +L L K E++ N ++ +E LQE +++E D+EL +L+
Sbjct: 1017 QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ 1076
Query: 269 -EENEKLRSLTFSLAEKDILEQ--------SLDEARGSRQELVERIHSLRERAVAAERQR 319
+E E+LR L E+ ++ + EA G + ++ +LR E+Q
Sbjct: 1077 IKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQC 1136
Query: 320 EQYWEEKEQTLLQFQKSKMACQLYREK-VNALQAQVCELQKERDQAYSARDSAQREISQS 378
++ +E+ +L + +++ A + R+ + LQ Q+ E +E + SA SAQRE++
Sbjct: 1137 QKQ-QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAF 1195
Query: 379 LVE-------KDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRL 431
+ +D + QV Q E + L E +L ++ +E +E +RL
Sbjct: 1196 RTKVQDHSKAEDEWKAQVAR-GRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL 1254
Query: 432 V------------RMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPP 479
V R+ + S+ + + S L ++ S RE + R +S
Sbjct: 1255 VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ--SLREEAEKQRVASENLR 1312
Query: 480 SQQSLYKRVAEDFGEE 495
+ + AE+ G+E
Sbjct: 1313 QELTSQAERAEELGQE 1328
Score = 45.1 bits (105), Expect = 3e-04
Identities = 75/355 (21%), Positives = 132/355 (37%), Gaps = 54/355 (15%)
Query: 121 TSKLTECLAGAIGSLQEELNQEKGQKEVLLR-----------RCQQLQEHLGLAETRAEG 169
T E L + L+++ +++ Q + L R R L+ G E +A+
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177
Query: 170 LHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLL 229
L ++ + +RE++A +V + QE E S SL+EE+ +L
Sbjct: 1178 LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237
Query: 230 KQ----------ELQRANMVSS------------CELELQEQSLRTASDQESGDEELNRL 267
+ EL+R M S + E S R A + EE+ L
Sbjct: 1238 NRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297
Query: 268 KEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKE 327
+EE EK R + +L RQEL + E + +E+++ +KE
Sbjct: 1298 REEAEKQRVASENL----------------RQELTSQAERAEELGQELKAWQEKFF-QKE 1340
Query: 328 QTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRR 387
Q L Q + Q ++ + +LQ E+ +A + E+ QS LR
Sbjct: 1341 QALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQ---AAAEKRHREELEQSKQAAGGLRA 1397
Query: 388 QVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAICPRDD 442
++ ++ EL LRQ AE +Q + + L + H + ++
Sbjct: 1398 ELLRAQRELGEL-IPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEEN 1451
Score = 43.9 bits (102), Expect = 8e-04
Identities = 82/369 (22%), Positives = 150/369 (40%), Gaps = 54/369 (14%)
Query: 124 LTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQ-EHLGLAETRAEGLHQLEADHS---- 178
L E L GSL+EE + E R +L+ E L E +LE + +
Sbjct: 707 LKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKG 766
Query: 179 ---RMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQR 235
R+++ AH E L+ E+ + A+ + A S C L +E+ ++ +
Sbjct: 767 LEARLQQLGEAHQAETEVLRREL-------AEAMAAQHTAESECEQLVKEVAAWRERYED 819
Query: 236 ANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEAR 295
+ QE++ A QE +L LKEE EK R EK +S E +
Sbjct: 820 SQ---------QEEAQYGAMFQE----QLMTLKEECEKARQELQEAKEKVAGIESHSELQ 866
Query: 296 GSRQ--ELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQ 353
SRQ EL E +H+ RA+ Q +EKE ++ QK +EK+ A +
Sbjct: 867 ISRQQNELAE-LHANLARAL-------QQVQEKE---VRAQKLADDLSTLQEKMAATSKE 915
Query: 354 VCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTD--QVCELRTQLRQLQAEP- 410
V L+ +A +++A RE+ + + + E Q C + L+ ++ E
Sbjct: 916 VARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAE 975
Query: 411 ----------PGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLS 460
+++ + + +E ++++ + R+ R +D +L + ++L L
Sbjct: 976 QMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQ 1035
Query: 461 ATSSRELVD 469
+ + V+
Sbjct: 1036 NALNEQRVE 1044
Score = 42.7 bits (99), Expect = 0.002
Identities = 53/232 (22%), Positives = 96/232 (41%), Gaps = 26/232 (11%)
Query: 223 QEELYLLKQEL--QRANMVSSCELELQE-QSLRTASDQESGDEELNRLKEENEKLRSLTF 279
Q ++ LK++L +R+N ELEL E + L T D + + +++ ++L L
Sbjct: 213 QFQMRRLKKQLADERSNR-DELELELAENRKLLTEKDAQ-----IAMMQQRIDRLALLNE 266
Query: 280 SLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMA 339
A + + L+E R + L R+H ++ + ++ Q + Q +
Sbjct: 267 KQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFK 326
Query: 340 CQLYREKVNALQAQVCELQKERDQA----YSARDSAQREISQSLVEKDSLRRQVFELTDQ 395
+ + + LQ + EL +E +A + ++E+S +L +K L + L +
Sbjct: 327 LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGK 386
Query: 396 VCELRTQLRQLQAEPP-------------GVLKQEARTREPCPREKQRLVRM 434
+ +L L QLQ PP LKQEA T + Q V M
Sbjct: 387 LSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEM 438
Score = 31.6 bits (70), Expect = 3.9
Identities = 74/395 (18%), Positives = 149/395 (37%), Gaps = 33/395 (8%)
Query: 136 QEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLK 195
Q++L + Q + Q+LQ L + + Q A+H +++ E + ++ + +
Sbjct: 1569 QQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA-AEHYKLQMEKAKTHYDAKKQQ 1627
Query: 196 DEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTAS 255
++ L L LQ++ + L+ E L ELQ+A + + + EQ+ R +
Sbjct: 1628 NQELQEQLRSLEQLQKEN------KELRAEAERLGHELQQAGL----KTKEAEQTCRHLT 1677
Query: 256 DQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAA 315
Q E ++ +++LR L D L+ +A+ ++ + E
Sbjct: 1678 AQVRSLEA--QVAHADQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPL 1735
Query: 316 ERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREI 375
+ + + T + + + Q KV +L++ R QA +S+ +
Sbjct: 1736 SITSKLPRTQPDGTSVPGEPASPISQRLPPKVESLESLYFTPIPARSQA--PLESSLDSL 1793
Query: 376 SQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREK------- 428
++ R T Q+ + T ++L E P + P +
Sbjct: 1794 GDVFLDSGRKTRSARRRTTQIINI-TMTKKLDVEEPDSANSSFYSTRSAPASQASLRATS 1852
Query: 429 --QRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPSQQSLYK 486
Q L R+ + D + +L+S + + SA S+ V SS APP + S Y
Sbjct: 1853 STQSLARLGS---PDYGNSALLSLPGYRPTTRSSARRSQAGV-----SSGAPPGRNSFYM 1904
Query: 487 RVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDP 521
+D E+ ++ E+ + + P K P
Sbjct: 1905 GTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYP 1939
>gi|46852390 coiled-coil domain containing 6 [Homo sapiens]
Length = 474
Score = 63.9 bits (154), Expect = 7e-10
Identities = 78/298 (26%), Positives = 143/298 (47%), Gaps = 31/298 (10%)
Query: 211 EKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRT-------ASDQESGDEE 263
E E +C++LQEE ++L++A++ E +E+ + A +E
Sbjct: 76 ELETYKLKCKALQEE----NRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLA 131
Query: 264 LNRLKEE----NEKLRSLTFSLAEKDILEQSLDEARGSR-QELVERIHSLRERAVAAERQ 318
+N KEE NE R L EK LEQ L++ + + +L+++I L ++ +
Sbjct: 132 VNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLT 191
Query: 319 REQYWEEK---EQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREI 375
EQ EK E TL Q Q++ + +L++ +++ L+A+ LQ++ DQ SA S R+I
Sbjct: 192 LEQLRREKIDLENTLEQEQEA-LVNRLWK-RMDKLEAEKRILQEKLDQPVSAPPSP-RDI 248
Query: 376 SQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAE----PPGVLKQEARTREPCPREKQRL 431
S + +++ R + L ++V L+ QLR Q + L++E RE R +++L
Sbjct: 249 SMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKL 308
Query: 432 ----VRMHAICPRDDSDCSLVSSTESQLLSDLSATSSR-ELVDSFRSSSPAPPSQQSL 484
R A+C + S + + + +++SA R V S +P+P S + +
Sbjct: 309 QREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPI 366
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 63.5 bits (153), Expect = 9e-10
Identities = 81/332 (24%), Positives = 146/332 (43%), Gaps = 42/332 (12%)
Query: 126 ECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQ--------EHLGLAETRAEGLHQLEADH 177
E L G++ +Q +L Q + ++E L Q L E GL + + D
Sbjct: 907 EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDK 966
Query: 178 SRMKRE-VSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRA 236
M ++ V A L+++ + +EKE A R L+ E L+ +LQR
Sbjct: 967 ELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA---WRELEAERAQLQSQLQRE 1023
Query: 237 N--MVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEA 294
+++ E E +E S A+ Q+ DE L L E+EK ++L+ +EK L + L
Sbjct: 1024 QEELLARLEAEKEELSEEIAALQQERDEGL--LLAESEKQQALSLKESEKTALSEKLMGT 1081
Query: 295 RGSRQELVERIHSLRERAVAAERQRE--QYWEEKEQTLLQFQKSKM---------ACQLY 343
R HSL ++ ERQ+ Q +E++++ + S++ A +
Sbjct: 1082 R----------HSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAH 1131
Query: 344 REKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQL 403
++V LQ Q +L K+RD + + ++ +D LRR++ E ++ E + +
Sbjct: 1132 AQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ-EG 1190
Query: 404 RQLQAEPPGVLKQE----ARTREPCPREKQRL 431
R++Q + G L++ A+ RE R + L
Sbjct: 1191 REVQRQEAGELRRSLGEGAKEREALRRSNEEL 1222
Score = 59.7 bits (143), Expect = 1e-08
Identities = 62/288 (21%), Positives = 123/288 (42%), Gaps = 27/288 (9%)
Query: 138 ELNQEKGQKEVLLRRCQQLQEHLGLAETR-----------AEGLHQLEADHSRMKREVSA 186
+L Q +G++ VL + +++E L A + AE L + EA ++ ++
Sbjct: 667 QLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTK 726
Query: 187 HFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELEL 246
E L+D + LS + Q+K L+EE L+ ++A ++ E
Sbjct: 727 LRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE 786
Query: 247 QEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIH 306
QE+ +QE + L SL + ++ LEQ L R R +L E++
Sbjct: 787 QERLEELRLEQEVARQGLEG---------SLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
Query: 307 SLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYS 366
L + E++ EQ E ++ + +++ + ++ L Q+ ++E
Sbjct: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGR---- 893
Query: 367 ARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVL 414
+ E ++ +EK++L +FE+ Q+ +L + QL+AE +L
Sbjct: 894 ---TLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALL 938
Score = 53.9 bits (128), Expect = 7e-07
Identities = 71/289 (24%), Positives = 130/289 (44%), Gaps = 19/289 (6%)
Query: 149 LLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNA 208
L +R Q+Q+ G E + L L S + E A ++ RL+D+ + +A
Sbjct: 528 LHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDA 587
Query: 209 LQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLK 268
+E + S L E L LQ A + EL+++ + + QE + +RL+
Sbjct: 588 QREVQRLRSANELLSREKSNLAHSLQVAQQQAE---ELRQEREKLQAAQEELRRQRDRLE 644
Query: 269 EENE-KLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKE 327
EE E ++ E + + L++ G R L + + +RE A QR+
Sbjct: 645 EEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRD------- 697
Query: 328 QTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQR--EISQSLV-EKDS 384
+LQ +K+++A L + + ++ ++ + K R + S +DS + +++SL +K
Sbjct: 698 --MLQAEKAEVAEALTKAEAGRVELEL-SMTKLRAEEASLQDSLSKLSALNESLAQDKLD 754
Query: 385 LRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVR 433
L R V +L ++ L Q RQ QAE + +E + R R +Q + R
Sbjct: 755 LNRLVAQLEEEKSAL--QGRQRQAEQEATVAREEQERLEELRLEQEVAR 801
Score = 53.1 bits (126), Expect = 1e-06
Identities = 85/381 (22%), Positives = 168/381 (44%), Gaps = 52/381 (13%)
Query: 128 LAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAH 187
LA + ++E L++ Q+++L ++ E L AE G +LE ++++ E ++
Sbjct: 678 LAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEA---GRVELELSMTKLRAEEASL 734
Query: 188 FHEVLRLK-------DEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVS 240
+ +L + L L+ + +EK R R ++E + ++E +R
Sbjct: 735 QDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLE--- 791
Query: 241 SCELELQEQ--------SLRTASD-QESGDEELNRLKEENEKLRSLTFSLAEK-DILEQS 290
EL L+++ SLR A QE+ +++L L+ E +L+ L+ + EQ
Sbjct: 792 --ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQE 849
Query: 291 LDEARGSRQELVERIH--------------SLRERAVAAERQREQYWEEKEQTLLQFQKS 336
L++AR Q VE + L + VAAER+ E E T L+ +K
Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSE--EATRLRLEKE 907
Query: 337 KMACQLY--REKVNALQAQVCELQKERDQAYSARDSAQREIS---QSLV---EKDSLRRQ 388
+ L+ + ++ L+A+ +L+ E A+++ E++ Q ++ EK SL ++
Sbjct: 908 ALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKE 967
Query: 389 VF--ELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPRE-KQRLVRMHAICPRDDSDC 445
+ +L E + LR+ +A L++ R +E RE + ++ + R+ +
Sbjct: 968 LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEEL 1027
Query: 446 SLVSSTESQLLSDLSATSSRE 466
E + LS+ A +E
Sbjct: 1028 LARLEAEKEELSEEIAALQQE 1048
Score = 51.6 bits (122), Expect = 4e-06
Identities = 72/306 (23%), Positives = 134/306 (43%), Gaps = 34/306 (11%)
Query: 134 SLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEV-- 191
S Q E ++ + Q L R+ +++ A +RA L + A+ +R V V
Sbjct: 1520 SAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQA 1579
Query: 192 -LRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQS 250
L L++E + S A ++ A+ RSLQ L+ ++ + + + E +L+
Sbjct: 1580 ELALQEESVRRSERERRATLDQ--VATLERSLQATESELRASQEKISKMKANETKLEGDK 1637
Query: 251 LRT-----ASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEA----------- 294
R AS+ + EL R E E RS L++++ Q+L +
Sbjct: 1638 RRLKEVLDASESRTVKLELQRRSLEGELQRS-RLGLSDREAQAQALQDRVDSLQRQVADS 1696
Query: 295 ---RGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQ-FQKSKMACQLYREKVNAL 350
G+ Q VER++ A+A + E +K + L + +S + R+K L
Sbjct: 1697 EVKAGTLQLTVERLNG----ALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHL 1752
Query: 351 QAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEP 410
Q + + +R D+A++ +S++ + SL QV L +V +L +L++++AE
Sbjct: 1753 QKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADL--ELQRVEAE- 1809
Query: 411 PGVLKQ 416
G L+Q
Sbjct: 1810 -GQLQQ 1814
Score = 48.1 bits (113), Expect = 4e-05
Identities = 76/325 (23%), Positives = 134/325 (41%), Gaps = 27/325 (8%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLG-----LAETRAEGLHQLEADH----SRMKREVS 185
LQ +L +E+ E LL R + +E L L + R EGL E++ S + E +
Sbjct: 1016 LQSQLQREQ---EELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKT 1072
Query: 186 AHFHEVLRLKDEMLSLSLHYS----NALQEKELAASRCRSLQEELYLLKQELQRANMVSS 241
A +++ + + ++SL +A +E S +L EL L+ + + A +
Sbjct: 1073 ALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHA 1132
Query: 242 CELE-LQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDI-----LEQSLDEAR 295
E+ LQEQ+ ++S E L+ + L L + + L +S +
Sbjct: 1133 QEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGRE 1192
Query: 296 GSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYRE----KVNALQ 351
RQE E SL E A E R EE + + + +++ +L E K+ L+
Sbjct: 1193 VQRQEAGELRRSLGEGAKEREALRRSN-EELRSAVKKAESERISLKLANEDKEQKLALLE 1251
Query: 352 AQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPP 411
+ KE + + +R ++ E LRRQ+ L + L +L +LQ
Sbjct: 1252 EARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Query: 412 GVLKQEARTREPCPREKQRLVRMHA 436
+ E +R +QRL++ A
Sbjct: 1312 LGERAEKESRRETLGLRQRLLKGEA 1336
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/237 (23%), Positives = 99/237 (41%), Gaps = 32/237 (13%)
Query: 106 LQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHL----- 160
L P + ++ L E ++L L + +++ L Q + +++ L + + E L
Sbjct: 67 LLPATEMASLLSLQEENQL---LQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALR 123
Query: 161 ---GLAETRA-EGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELA- 215
G ET+ GL + + R +E A + L+ E LQ K L
Sbjct: 124 LEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQY 183
Query: 216 ASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLR 275
RC L+++L L+R+ EL++Q LR + + L RL+EE ++
Sbjct: 184 KKRCSELEQQL------LERSG-------ELEQQRLRDTEHSQDLESALIRLEEEQQRSA 230
Query: 276 SLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQ---REQYWEEKEQT 329
SL A +L + LD+A + Q L E I + ++ RE W +E++
Sbjct: 231 SLAQVNA---MLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEES 284
Score = 45.1 bits (105), Expect = 3e-04
Identities = 60/243 (24%), Positives = 101/243 (41%), Gaps = 21/243 (8%)
Query: 207 NALQEKELAASRCRSLQEELYLLKQELQRANMVSSCE---LELQEQSLRTASD-----QE 258
+AL +++L R E L L++ S E LE Q Q LR +D E
Sbjct: 526 SALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHE 585
Query: 259 SGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQ 318
E+ RL+ NE L EK L SL A+ +EL + L+ RQ
Sbjct: 586 DAQREVQRLRSANELLSR------EKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQ 639
Query: 319 REQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSA--RDSAQREIS 376
R++ EE+E + + + + ++ L+ + L KE + A R + QR++
Sbjct: 640 RDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDML 699
Query: 377 QSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGV---LKQEARTREPCPREKQRLVR 433
Q+ EK + + + EL + +L+AE + L + + E ++K L R
Sbjct: 700 QA--EKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNR 757
Query: 434 MHA 436
+ A
Sbjct: 758 LVA 760
Score = 42.4 bits (98), Expect = 0.002
Identities = 91/376 (24%), Positives = 160/376 (42%), Gaps = 54/376 (14%)
Query: 133 GSLQEE---LNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFH 189
G LQ L+ + Q + L R LQ + +E +A G QL +
Sbjct: 1663 GELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKA-GTLQLTVERLNGALAKVEESE 1721
Query: 190 EVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQ 249
LR K L+ +L S+A L ++R ++L LQ+A +++CE + Q
Sbjct: 1722 GALRDKVRGLTEALAQSSA----SLNSTRDKNLH---------LQKA--LTACEHDRQVL 1766
Query: 250 SLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLR 309
R + +++ E + E++++L +A+ LE EA G Q+L E + +
Sbjct: 1767 QERLDAARQALSEARKQSSSLGEQVQTLRGEVAD---LELQRVEAEGQLQQLREVLRQRQ 1823
Query: 310 ERAVAAERQREQYWEEK---EQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYS 366
E AA ++ +E+ ++ L Q++ QL EK ++ L+K+R
Sbjct: 1824 EGEAAALNTVQKLQDERRLLQERLGSLQRA--LAQLEAEK-REVERSALRLEKDRVALRR 1880
Query: 367 ARDSAQREISQS-------LVEKDSLRRQVFELTDQVCELRTQLRQLQAE--------PP 411
D +RE +S EK L R + ++ E + Q++QL+A+ P
Sbjct: 1881 TLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSP 1940
Query: 412 GVLKQEARTRE-PCPREKQRLVRMHA-----ICPRDDSDCSLVSSTESQLLSDLSATSSR 465
L+ +A+ ++ +E +RL A + R+ + V E Q +S L +
Sbjct: 1941 AQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQ-VSTLKGQLQQ 1999
Query: 466 ELVDSFRSSSP-APPS 480
EL RSS+P +PPS
Sbjct: 2000 EL---RRSSAPFSPPS 2012
Score = 42.0 bits (97), Expect = 0.003
Identities = 54/202 (26%), Positives = 86/202 (42%), Gaps = 19/202 (9%)
Query: 130 GAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFH 189
G + L+E L Q + + L Q+LQ+ L + R L + A KREV
Sbjct: 1810 GQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVE---R 1866
Query: 190 EVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQ 249
LRL+ + ++L +EK RS ++ + L ++ + ++ ELEL E
Sbjct: 1867 SALRLEKDRVALRRTLDKVEREK------LRSHEDTVRLSAEKGRLDRTLTGAELELAE- 1919
Query: 250 SLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDI-LEQSLDEARGSRQELVERIHSL 308
A Q E + E++ L ++ + L+Q ++ R S Q ER
Sbjct: 1920 ----AQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLR-SAQAQTERTLEA 1974
Query: 309 RERAVAAERQREQYWEEKEQTL 330
RER A RQR + EE+ TL
Sbjct: 1975 RER---AHRQRVRGLEEQVSTL 1993
Score = 32.7 bits (73), Expect = 1.8
Identities = 76/384 (19%), Positives = 156/384 (40%), Gaps = 52/384 (13%)
Query: 132 IGSLQEELNQEKGQK------EVLLRRCQQLQEHLGLAETRAEGLHQ-LEADHSRMKREV 184
+GSL+E EK Q E+ L + LGL + AEG Q LEA+ +R++ +
Sbjct: 1367 LGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQR 1426
Query: 185 SAHFHEVLRLKDEML-SLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCE 243
A ++ L+ + L L + + + + S R E E + C
Sbjct: 1427 RAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEG---SGEGLNSPSTLECS 1483
Query: 244 LELQEQSLRTASDQESGD--------------EELNRLKEENEKLRSLTFSL-------- 281
Q S A+ S D +EL + E ++LR+ T +L
Sbjct: 1484 PGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEME 1543
Query: 282 AEKDI-------LEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQ-- 332
AE+D L++++ E+ +R+ + R+ ++ E + E+ TL Q
Sbjct: 1544 AERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVA 1603
Query: 333 -----FQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRR 387
Q ++ + +EK++ ++A +L+ ++ + D+++ + +++ SL
Sbjct: 1604 TLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEG 1663
Query: 388 QVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMH-AICPRDDSDCS 446
++ + + Q + LQ + +Q A + + + R++ A+ ++S+ +
Sbjct: 1664 ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA 1723
Query: 447 LVSS----TESQLLSDLSATSSRE 466
L TE+ S S S+R+
Sbjct: 1724 LRDKVRGLTEALAQSSASLNSTRD 1747
Score = 31.2 bits (69), Expect = 5.1
Identities = 40/180 (22%), Positives = 73/180 (40%), Gaps = 23/180 (12%)
Query: 140 NQEKGQKEVLLRRCQQ-LQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEM 198
N++K QK LL + + + G T GL ++E +RE+ ++ L E
Sbjct: 1240 NEDKEQKLALLEEARTAVGKEAGELRT---GLQEVERSRLEARRELQELRRQMKMLDSEN 1296
Query: 199 LSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQE 258
L + L + + E L+Q L + LE+ Q L+ A
Sbjct: 1297 TRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGE----ASLEVMRQELQVAQ--- 1349
Query: 259 SGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQ 318
+L+E+ + R+ E+ +L SL+EARG+ ++ ++ L + AA +
Sbjct: 1350 ------RKLQEQEGEFRT-----RERRLLG-SLEEARGTEKQQLDHARGLELKLEAARAE 1397
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 63.2 bits (152), Expect = 1e-09
Identities = 55/290 (18%), Positives = 130/290 (44%), Gaps = 13/290 (4%)
Query: 133 GSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVL 192
G ++E+ Q + Q+ + + Q++E G + + + E + ++ ++
Sbjct: 157 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQ 216
Query: 193 RLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLR 252
+ +++M QE+++ + ++E + KQE Q ++ QE+ +R
Sbjct: 217 KQEEQM---------GEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEE--QMRKQEEQMR 265
Query: 253 TASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERA 312
+Q EE LK++ + + E+ + EQ ++ R +++ E+ +RE+
Sbjct: 266 EQEEQMREQEE-QMLKQKEQTEQEEQTGEQEEQMREQE-EQMREQEEQMREQEEQMREQE 323
Query: 313 VAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQ 372
+Q EQ WE+KEQ Q ++ + E+ +Q Q +++K+ +Q + +
Sbjct: 324 EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMR 383
Query: 373 REISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTRE 422
++ Q +++ + Q ++ +Q ++R Q Q+ + + KQE E
Sbjct: 384 KQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGE 433
Score = 36.6 bits (83), Expect = 0.12
Identities = 37/215 (17%), Positives = 96/215 (44%), Gaps = 3/215 (1%)
Query: 210 QEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKE 269
+E +L + +Q + LK++L+ + E +++EQ + + E+ +++E
Sbjct: 18 EELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVRE 77
Query: 270 ENEKLRSLTFSLAEKD--ILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKE 327
+ ++R + E++ + EQ + R ++ E+ +RE+ Q Q E++
Sbjct: 78 QEGQVREQEGQVREQEGQVREQE-GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 136
Query: 328 QTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRR 387
Q Q + + RE+ ++ Q +++++ Q + + Q ++ +
Sbjct: 137 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGE 196
Query: 388 QVFELTDQVCELRTQLRQLQAEPPGVLKQEARTRE 422
Q ++ +Q ++ Q Q+Q + + +QE + R+
Sbjct: 197 QEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK 231
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 63.2 bits (152), Expect = 1e-09
Identities = 82/356 (23%), Positives = 157/356 (44%), Gaps = 25/356 (7%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLA----ETRAEGLHQLEADHSRMKREVSAHFHE 190
+Q +L ++ L+ + LQE L LA E + L +E+ S +E
Sbjct: 1481 IQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGR 1540
Query: 191 VLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQS 250
+ L++E L +L E + +S C SL+ L L ++ ++ +V E L+
Sbjct: 1541 LALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEK--LVKEIE-SLKSSK 1597
Query: 251 LRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRE 310
+ +++ + +EL KE L+S E + ++ ++ R +QEL ++ S
Sbjct: 1598 IAESTEWQEKHKELQ--KEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEA 1655
Query: 311 RAVAAERQ---REQYWEEKEQTLLQFQKSKMACQLYREKVN-ALQAQV---CELQKE-RD 362
E+Q EQ EE ++ + +F KSK L E+ N L+A+V + KE +
Sbjct: 1656 NKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECME 1715
Query: 363 QAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTRE 422
S+ S + E+ + +E ++L ++ L + L +++ L+ + G + ++A
Sbjct: 1716 TLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEA 1775
Query: 423 PCPREKQRLVRMHAICPRDDSDCSLVSSTESQ-LLSDLSATSSRELVDSFRSSSPA 477
+ Q V ++ S+ TE Q LS + + E V S +S++PA
Sbjct: 1776 TEKHDNQTNV-------TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPA 1824
Score = 53.1 bits (126), Expect = 1e-06
Identities = 67/305 (21%), Positives = 136/305 (44%), Gaps = 43/305 (14%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRL 194
L+ +Q+ + VLL ++ QE + + + +G EADH + ++ E+ ++
Sbjct: 548 LENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQK------EMKQM 601
Query: 195 KDE---MLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMV----SSCELELQ 247
+ E + + + + Q+ L + EE L E ++A+ +S E+ L
Sbjct: 602 EGEGIAPIKMKVFLEDTGQDFPLMPN------EESSLPAVEKEQASTEHQSRTSEEISLN 655
Query: 248 EQSLRTASDQESGDEELNRL-------KEENEKLRSLTFSL-----AEKDILEQSLDEAR 295
+ + S ++ GD+ L+ + ++E E+L+S L ++I E++LDE
Sbjct: 656 DAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKA 715
Query: 296 GSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVC 355
L + I ++ A EE++Q L Q ++ M +L R +V L+ +
Sbjct: 716 KEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTEL-RAQVKQLEMNLA 774
Query: 356 ELQKERDQAY---SARDSAQREISQSL--------VEKDSLRRQVFELTDQVCELRTQLR 404
E +++R Y +A D+ E SL V+ + L+ ++ ++ Q E T +R
Sbjct: 775 EAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIR 834
Query: 405 QLQAE 409
LQ++
Sbjct: 835 SLQSQ 839
Score = 50.4 bits (119), Expect = 8e-06
Identities = 81/344 (23%), Positives = 144/344 (41%), Gaps = 47/344 (13%)
Query: 111 DFSNFSGLMET-SKLTECLAGAIGSLQEE----LNQEKGQKEVLLRRCQQLQEHLGLAET 165
+ SN + L+E K + + A +L EE L+Q K V R Q Q + LAE
Sbjct: 717 EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEA 776
Query: 166 R-----------------AEGLHQL--EADHSRMKREVSAHFHEVLRLK-DEMLSLSLHY 205
E +H L EA +K EV + + ++L+ E +L
Sbjct: 777 ERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSL 836
Query: 206 SNALQEKEL----AASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGD 261
+ LQ KE A R R + ++ L Q L S ELE+ + + +
Sbjct: 837 QSQLQNKESEVLEGAERVRHISSKVEELSQAL------SQKELEITKMDQLLLEKKRDVE 890
Query: 262 EELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQ 321
++E+++++ ++FS+ EK + L+E + S L I +L+E+ R E
Sbjct: 891 TLQQTIEEKDQQVTEISFSMTEKMV---QLNEEKFS---LGVEIKTLKEQLNLLSRAEEA 944
Query: 322 YWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVE 381
+KEQ + S Q Y E A Q ELQ E D + +R++ +L+
Sbjct: 945 ---KKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001
Query: 382 KDSLRRQVFELTDQVCELRTQLRQ---LQAEPPGVLKQEARTRE 422
+ L ++V L +++ L+ + ++ L G ++++ +E
Sbjct: 1002 RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKE 1045
Score = 47.8 bits (112), Expect = 5e-05
Identities = 70/299 (23%), Positives = 131/299 (43%), Gaps = 58/299 (19%)
Query: 135 LQEELNQEKGQKEVLLRRCQQ---LQEHLGLAETR----AEGLHQLEADHSRMKREVSAH 187
LQ +L + + E L+ R Q LQ+ L AE R ++ L Q+EA+H+ ++ V
Sbjct: 257 LQRKLEEHE---ESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETE 313
Query: 188 FHEVLRLKDEMLSLSLHYSNALQEKELAASRC--RSLQEELYLLKQELQRANMVSS---- 241
E L ++M E E+A + +LQEE++ L ++ ++A +
Sbjct: 314 REESKILLEKM------------ELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELES 361
Query: 242 --------CELELQEQSLRTASDQESGDE---ELNRLKEENEKLRSLTFSLAEKDILEQS 290
+ E++E++ S Q++G E + LK++N KL L +K+ EQ+
Sbjct: 362 RYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL------LQDKN--EQA 413
Query: 291 LDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNAL 350
+ A+ +Q + +E + R Q E QT ++ + E + +L
Sbjct: 414 VQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASL 473
Query: 351 QAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAE 409
Q +V EL+ E+ + S +E + L+ + +L+ Q+ L Q R +A+
Sbjct: 474 QKRVVELENEKG-----------ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEAD 521
Score = 47.8 bits (112), Expect = 5e-05
Identities = 81/416 (19%), Positives = 169/416 (40%), Gaps = 63/416 (15%)
Query: 126 ECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQ-EHLGLAETRAEGLHQLEADHSRMKREV 184
E L + S++EEL + K + E L ++ Q L E L+E + HQ+E + S+
Sbjct: 1715 ETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLE 1774
Query: 185 SAHFHE------------VLRLKDEMLSLSLHYSNALQEK-------ELAASRCRSLQEE 225
+ H+ + +E SLS+ E A S+ S +E
Sbjct: 1775 ATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834
Query: 226 LYLLKQEL-QRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEK 284
+ Q++ Q ++ E E Q+ + + + + L+++ ++ +L+ L + +
Sbjct: 1835 INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894
Query: 285 DILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKS-------- 336
++L Q + QE + R+ L+E AE +++ E L + S
Sbjct: 1895 NLLNQQI-------QEELSRVTKLKE---TAEEEKDDLEERLMNQLAELNGSIGNYCQDV 1944
Query: 337 ---KMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEK-------DSLR 386
++ +L ++ L+ V EL++E+ Q + + EI + +EK +
Sbjct: 1945 TDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK 2004
Query: 387 RQVFELTDQVCELRTQLRQLQ------AEPPGVLKQEARTREPCPREKQRLVRM------ 434
EL + + E + +++QLQ E L++ + E E Q+ + +
Sbjct: 2005 SHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLA 2064
Query: 435 HAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPSQQSLYKRVAE 490
A+ R + L S LL D + ++R L D+ + +++S+ ++ +
Sbjct: 2065 QAVEHRKKAQAELASF--KVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118
Score = 46.6 bits (109), Expect = 1e-04
Identities = 71/346 (20%), Positives = 137/346 (39%), Gaps = 60/346 (17%)
Query: 111 DFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGL 170
DFS+ + + + L I L+EE + K + L L + + + L
Sbjct: 1828 DFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKML 1887
Query: 171 HQLEADHSRMKREVSAHFHEVLRLK----DEMLSLSLHYSNALQE-KELAASRCRSLQEE 225
+ + + +++ V +LK +E L N L E + C+ + +
Sbjct: 1888 QEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA 1947
Query: 226 LYLLKQELQRANM--VSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAE 283
+K EL + M + C EL +EE +L +E K+ E
Sbjct: 1948 --QIKNELLESEMKNLKKCVSEL--------------EEEKQQLVKEKTKV--------E 1983
Query: 284 KDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLY 343
+I ++ L++ +G+++E + H+ ++ ++ +EK+Q + Q QK C Y
Sbjct: 1984 SEIRKEYLEKIQGAQKEPGNKSHA---------KELQELLKEKQQEVKQLQKD---CIRY 2031
Query: 344 REKVNALQAQV-------CELQKERD-------QAYSARDSAQREISQSLVEKDSLRRQV 389
+EK++AL+ V E QK+ + QA R AQ E++ V D + +
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEA 2091
Query: 390 FELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMH 435
+ +L+ ++LQ+ V Q + E R ++ H
Sbjct: 2092 ARVLADNLKLK---KELQSNKESVKSQMKQKDEDLERRLEQAEEKH 2134
Score = 45.8 bits (107), Expect = 2e-04
Identities = 68/336 (20%), Positives = 137/336 (40%), Gaps = 44/336 (13%)
Query: 128 LAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETR----AEGLHQLEADHSRMKRE 183
L IG +Q LN K KEV QQLQE+L T+ + + L+ D R+ E
Sbjct: 2155 LEETIGEIQVTLN--KKDKEV-----QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207
Query: 184 VSA---HFHEVLRLKDEMLSLSLHYSNALQEKELAAS-RCRSLQEELYLLKQELQRANMV 239
F + ++ K+E + L + L+++ S L+ + L+ + Q
Sbjct: 2208 AKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESK 2267
Query: 240 SSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQ 299
+ E++LQ++ T Q E L++L+E S LA+ LE L +
Sbjct: 2268 AQTEVQLQQKVCDTL--QGENKELLSQLEETRHLYHSSQNELAK---LESELKSLKDQLT 2322
Query: 300 ELVERIHSLRE---------RAVAAERQREQYWEEKEQTLLQFQKSKMACQLYRE----- 345
+L + +E R A+ Q ++ E+ +T LQ + ++ +L+ E
Sbjct: 2323 DLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASR-ELTSRLHEEINMKE 2381
Query: 346 ---------KVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQV 396
K A+Q + EL+++ D+ ++ + + + + ++ + T+Q+
Sbjct: 2382 QKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQL 2441
Query: 397 CELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLV 432
E +++ + L ++ ++ R+V
Sbjct: 2442 METLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV 2477
Score = 42.0 bits (97), Expect = 0.003
Identities = 58/319 (18%), Positives = 136/319 (42%), Gaps = 29/319 (9%)
Query: 120 ETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEH---LGLAETRAEGLHQLEAD 176
E K + AI S +EE+ ++ VL + +Q+ H L + +R E Q+
Sbjct: 2207 EAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWES 2266
Query: 177 HSRMKREVSAHFHEVLRLKDEMLSLSLHYSNAL---QEKELAA--SRCRSLQEELYLLKQ 231
++ + ++ + L+ +++ L L + L + ELA S +SL+++L L
Sbjct: 2267 KAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSN 2326
Query: 232 ELQRAN--------MVSSCELELQEQSL---RTASDQESGDEELNRLKEENEKLRSLTFS 280
L++ ++ E ++Q + +D ++ E +RL EE S
Sbjct: 2327 SLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIIS 2386
Query: 281 L--AEKDILEQSLDEARGSRQELVERIHSL----RERAVAAERQREQYWEEKEQTLLQFQ 334
L +++ ++ ++ E R + ++ + +L E + E + ++ ++ Q + +
Sbjct: 2387 LLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLK 2446
Query: 335 KSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVF---- 390
K + ++++ + LQ +RD+ + ++EKD L ++
Sbjct: 2447 TIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENN 2506
Query: 391 ELTDQVCELRTQLRQLQAE 409
+L +++ LR+ + L +E
Sbjct: 2507 KLKEEIRGLRSHMDDLNSE 2525
Score = 41.6 bits (96), Expect = 0.004
Identities = 58/248 (23%), Positives = 108/248 (43%), Gaps = 20/248 (8%)
Query: 134 SLQEELNQEKGQKEVL--LRRCQ-QLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHE 190
SLQ++L + Q L LR Q +L E L + E + L S + ++ E
Sbjct: 1369 SLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTE 1428
Query: 191 VLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQS 250
++ +D L +LH +Q KE R + LQ EL +KQ+ + S + ++Q +
Sbjct: 1429 IIEQED--LIKALHTQLEMQAKE-HDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
Query: 251 LRTASDQESGDEELNRLKEENEKLRS----LTFSLAEKDILEQSLDEARGSRQELVERIH 306
++ +E L+EE R LT SLA+ +E + + ++ R+
Sbjct: 1486 QAALISRKEALKENKSLQEELSLARGTIERLTKSLAD---VESQVSAQNKEKDTVLGRLA 1542
Query: 307 SLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYS 366
L+E +R++ E +++LL+ Q +C+ + + L +L KE + S
Sbjct: 1543 LLQE-------ERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKS 1595
Query: 367 ARDSAQRE 374
++ + E
Sbjct: 1596 SKIAESTE 1603
Score = 40.0 bits (92), Expect = 0.011
Identities = 66/368 (17%), Positives = 144/368 (39%), Gaps = 29/368 (7%)
Query: 48 VLCQLDEEEVLHSPRLTNSAMRAGHLLDLLKTRGKNGAI------AFLESLKFHNPDVYT 101
+L Q +EE ++ + + L++ LKT K +F++S+ D
Sbjct: 2416 LLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDR 2475
Query: 102 LVTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLG 161
+V Q ++ + S ++E +L + A L+EE+ + + L +L L
Sbjct: 2476 IVGDYQ-QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL- 2533
Query: 162 LAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRS 221
+ R + + S+ K+ + + L+++ L + + E +
Sbjct: 2534 -IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNA 2592
Query: 222 LQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELN----RLKEENEKLRSL 277
LQEE KQ+L + + S ++ + + + + + QE G L ++KEE S
Sbjct: 2593 LQEE----KQDLSKE--IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSA 2646
Query: 278 TFSLAEKDILE----------QSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKE 327
FS ++K I E ++ + +L + + L A + E E
Sbjct: 2647 LFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVA 2706
Query: 328 QTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRR 387
+ + + + ++ L AQ+ + ++RD A E+ + + D+ +
Sbjct: 2707 ELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLK 2766
Query: 388 QVFELTDQ 395
++ +L +Q
Sbjct: 2767 ELAQLKEQ 2774
Score = 39.7 bits (91), Expect = 0.014
Identities = 72/309 (23%), Positives = 123/309 (39%), Gaps = 43/309 (13%)
Query: 137 EELNQEKGQK-EVLLRRCQQLQEHLGLAETRAEGLHQL--EADH---------------S 178
E+LNQ+ K E LL QL++ ++ ++ + L E DH
Sbjct: 2804 EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQ 2863
Query: 179 RMKREVSAHFHEVLRLKDEMLSLSLHYSNALQE-KELAASRCRSLQE--ELYLLKQELQR 235
R + S EV LK M SL L+E K L + QE EL+ LK +LQ
Sbjct: 2864 RSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQE 2923
Query: 236 ANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEAR 295
+ ++ ++ LR + S EL++L+ E ++ + E+ + EQ L
Sbjct: 2924 YQDKTKA-FQIMQEELR--QENLSWQHELHQLRMEKS-----SWEIHERRMKEQYLMAIS 2975
Query: 296 GSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVC 355
Q+L + +RE ++ + + + + Q + S Q + L+ Q+
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLN 3035
Query: 356 ELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCE--------------LRT 401
+ KE Q SQ L EK++L Q+ + + + E L
Sbjct: 3036 DSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEK 3095
Query: 402 QLRQLQAEP 410
Q+++LQA P
Sbjct: 3096 QVQELQAGP 3104
Score = 38.1 bits (87), Expect = 0.042
Identities = 54/321 (16%), Positives = 131/321 (40%), Gaps = 47/321 (14%)
Query: 128 LAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLG-LAETRAEGLHQLEADHSRMKREV-- 184
L G + S + + + Q + + ++++E + A+++ + + +LE ++ R++ EV
Sbjct: 1646 LYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHP 1705
Query: 185 ----SAHFHEVL-----RLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQR 235
+ E L +K+E+ + + Y ++ + S SL EE+ LK +++
Sbjct: 1706 AGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE- 1764
Query: 236 ANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEAR 295
N+ LE E+ + E G + + EE + L S++ + +S+ A+
Sbjct: 1765 GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSL-----SMSTRPTCSESVPSAK 1819
Query: 296 GSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVC 355
+ + + S E Y ++++ L+ ++
Sbjct: 1820 SANPAVSKDFSSHDE-----------------------------INNYLQQIDQLKERIA 1850
Query: 356 ELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLK 415
L++E+ + + + E + L + + ++ L ++V ++ +Q+Q E V K
Sbjct: 1851 GLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK 1910
Query: 416 QEARTREPCPREKQRLVRMHA 436
+ E ++RL+ A
Sbjct: 1911 LKETAEEEKDDLEERLMNQLA 1931
Score = 37.4 bits (85), Expect = 0.071
Identities = 50/245 (20%), Positives = 103/245 (42%), Gaps = 50/245 (20%)
Query: 170 LHQLEADHS---RMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEEL 226
LH+L D M+ + H+ + ++N QE +QE L
Sbjct: 13 LHELSGDDDTDQNMRAPLDPELHQ---------ESDMEFNNTTQE---------DVQERL 54
Query: 227 YLLKQ-ELQRANMVSSCELELQEQSLRTASDQESGDEELNRLK-EENEKLRSLTFSLAEK 284
+Q ++ +++ +++LQ++ ++++ D ++ +LK KL SL + E
Sbjct: 55 AYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEM 114
Query: 285 DILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYR 344
+A+G ++ +E Q ++ + + ++ +K K Q
Sbjct: 115 --------KAQGG---------TVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKE 157
Query: 345 EKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLR 404
E ++ LQAQ+ + Q E+ A+ S + E E +++Q+ E + + L+ QL
Sbjct: 158 ELISTLQAQLTQAQAEQ----PAQSSTEME------EFVMMKQQLQEKEEFISTLQAQLS 207
Query: 405 QLQAE 409
Q QAE
Sbjct: 208 QTQAE 212
Score = 35.4 bits (80), Expect = 0.27
Identities = 79/372 (21%), Positives = 147/372 (39%), Gaps = 71/372 (19%)
Query: 132 IGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEAD--------------H 177
+ SL++ ++ + ++ LL+ + LQ+ LH L+A
Sbjct: 2876 VQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQ 2935
Query: 178 SRMKREVSAHFHEVLRLKDEMLSLSLH-------YSNALQEKELAASRCRSLQEELYLLK 230
+++E + HE+ +L+ E S +H Y A+ +K+ S ++L EL
Sbjct: 2936 EELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIREL---- 2991
Query: 231 QELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRS-LTFSLAEKDILEQ 289
R++ + L++Q Q + S D N L E E LR+ L SL E E
Sbjct: 2992 ----RSSSSQTQPLKVQYQRQASPETSASPDGSQN-LVYETELLRTQLNDSLKEIHQKEL 3046
Query: 290 SLDEARGSRQELVERIHSLRERAVAAE---RQREQYWEEKEQTLLQFQKSKMACQLYREK 346
+ + + +L+E ++L + R+ +Q++ + LL C + ++
Sbjct: 3047 RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGD----LLNH------CAVLEKQ 3096
Query: 347 VNALQAQVCELQ------KERDQAYSARDSAQ-REISQSLVEKDSLRRQVFELTDQVCEL 399
V LQA + +E++ + D + RE QS E Q+C
Sbjct: 3097 VQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQ----------QQLCNT 3146
Query: 400 RTQLRQLQAEPPGVLKQEARTR---EPCPREKQRLVRMHAICPRDDSDCSLVSS---TES 453
R ++ +L+ +L++E R E + +R D S ++ S E
Sbjct: 3147 RQEVNELRK----LLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQEQ 3202
Query: 454 QLLSDLSATSSR 465
LL DL++ S R
Sbjct: 3203 ALLIDLTSNSCR 3214
Score = 33.5 bits (75), Expect = 1.0
Identities = 66/335 (19%), Positives = 127/335 (37%), Gaps = 63/335 (18%)
Query: 134 SLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLR 193
S+ E++ Q +K L + L+E L L E + + + + + ++ E +
Sbjct: 909 SMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDE-MS 967
Query: 194 LKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRT 253
++ L + L +KE R R LQ L K+ LQR + + L+++S +
Sbjct: 968 PAGQISKEELQHEFDLLKKE-NEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKE 1026
Query: 254 ASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAV 313
E+ E+ KE E S ++ +E L + ++ ++ I E +
Sbjct: 1027 IPLSETERGEVEEDKENKEYSEKCVTSKCQE--IEIYLKQTISEKEVELQHIRKDLEEKL 1084
Query: 314 AAERQREQYWEEKEQTL---------LQFQKSKMACQLYR-------------------- 344
AAE Q + ++ QTL LQ + S+ + +
Sbjct: 1085 AAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKET 1144
Query: 345 -------------------EKVNALQAQVCELQKERDQAYSARDS-----------AQRE 374
EK+ AL+ + +LQK+ +A ++R + + E
Sbjct: 1145 VVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREE 1204
Query: 375 ISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAE 409
+ Q + + L+ Q E + + + QLRQLQ +
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ 1239
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 62.8 bits (151), Expect = 2e-09
Identities = 86/383 (22%), Positives = 158/383 (41%), Gaps = 59/383 (15%)
Query: 47 KVLCQLDEEE-----------VLHSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLKFH 95
K +CQL EE+ HS +T L +LL+T + L+ +
Sbjct: 350 KTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQR--------LEKN 401
Query: 96 NPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQ 155
+ L LQ S L E +KLT + EEL + G+KE LL +Q
Sbjct: 402 EDQLKILTMELQ-----KKSSELEEMTKLTNNKEVEL----EELKKVLGEKETLLYENKQ 452
Query: 156 L-----------QEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLH 204
QE +GL + R + +H LE + + + EV LK E
Sbjct: 453 FEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTE------- 505
Query: 205 YSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGD-EE 263
L+ ++L + S +L L +EL + + EL+ Q++ + QE ++
Sbjct: 506 ----LENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQ 561
Query: 264 LNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYW 323
+ L+E +LR+ + E+ L+Q DE + + E ++LR++ + E+
Sbjct: 562 IENLQETETQLRNELEYVREE--LKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQ 619
Query: 324 EEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKD 383
+E + + +Y KVN L+ EL+ + + D+ Q+EI + ++
Sbjct: 620 QENKALKKKGTAESKQLNVYEIKVNKLE---LELESAKQKFGEITDTYQKEIEDKKISEE 676
Query: 384 SLRRQVFE---LTDQVCELRTQL 403
+L +V + + D+ +L+ ++
Sbjct: 677 NLLEEVEKAKVIADEAVKLQKEI 699
Score = 47.0 bits (110), Expect = 9e-05
Identities = 62/295 (21%), Positives = 127/295 (43%), Gaps = 35/295 (11%)
Query: 120 ETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSR 179
E ++ T + + + QE++N K Q+E +L++ + LQE ET+ + + +
Sbjct: 529 ELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQE----TETQLRNELEYVREELK 584
Query: 180 MKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQ----ELQR 235
KR+ +K ++ + +N ++ E LQ+E LK+ E ++
Sbjct: 585 QKRD---------EVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQ 635
Query: 236 ANM----VSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSL 291
N+ V+ ELEL+ + ++ +E+ K E L L E + +
Sbjct: 636 LNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENL------LEEVEKAKVIA 689
Query: 292 DEARGSRQELVERI-HSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNAL 350
DEA ++E+ +R H + E E+ + QY +++ + S++ LY+ K
Sbjct: 690 DEAVKLQKEIDKRCQHKIAEMVALMEKHKHQY-----DKIIEERDSELG--LYKSKEQEQ 742
Query: 351 QAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQ 405
+ L+ E + S ++++ EK+ L+R+ E T + E + + Q
Sbjct: 743 SSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQ 797
Score = 38.5 bits (88), Expect = 0.032
Identities = 80/379 (21%), Positives = 150/379 (39%), Gaps = 54/379 (14%)
Query: 51 QLDEEEVLHSPRLTNSAMRAGHLLDLLKT------RGKNGAIAFLESLKFHNPDVYTLVT 104
QL+E+ L S L S + HL L+ R + A E L+ + L
Sbjct: 298 QLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTE 357
Query: 105 GLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAE 164
+ ++ SN + + +TE + SL+E L E+ + E + + L L
Sbjct: 358 EKETQMEESNKARAAHSFVVTE-FETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKS 416
Query: 165 TRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQE 224
+ E + +L + E+ +VL K+ +L Y N EK A + ++
Sbjct: 417 SELEEMTKLTNNKEVELEELK----KVLGEKETLL-----YENKQFEK--IAEELKGTEQ 465
Query: 225 ELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTF----- 279
EL L Q ++ +LE+Q ++ T+ S + + + + ENEKL++
Sbjct: 466 ELIGLLQAREK----EVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCN 521
Query: 280 --SLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSK 337
SL K++ +++ D EL + + ER +Q E ++T Q +
Sbjct: 522 KLSLENKELTQETSDMTL----ELKNQQEDINNNKKQEERMLKQI-ENLQETETQLRN-- 574
Query: 338 MACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVC 397
EL+ R++ RD + ++ +S ++LR+QV +
Sbjct: 575 ------------------ELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIE 616
Query: 398 ELRTQLRQLQAEPPGVLKQ 416
EL+ + + L+ + KQ
Sbjct: 617 ELQQENKALKKKGTAESKQ 635
Score = 37.4 bits (85), Expect = 0.071
Identities = 62/301 (20%), Positives = 120/301 (39%), Gaps = 46/301 (15%)
Query: 116 SGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQ--- 172
S L E K+ E AI LQ G ++V L+ + +QE+ L + H
Sbjct: 132 SKLQENRKIIEAQRKAIQELQF------GNEKVSLKLEEGIQENKDLIKENNATRHLCNL 185
Query: 173 LEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQE-----KELAASRCRSLQEELY 227
L+ +R + + +E ++E + + +N +++ +EL S E +
Sbjct: 186 LKETCARSAEKTKKYEYE----REETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHF 241
Query: 228 LLKQELQRANMVSSCELELQEQSLRTASDQESGDEELN-RLKEENEKLRSLTFSLAEKDI 286
LK++ ++ L+++ + +D+E L ++ E+ K++ LTF L
Sbjct: 242 KLKEDYEKIQ-------HLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLL----- 289
Query: 287 LEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREK 346
+E+R +L E+ E + ++ +E E + Q+S + E
Sbjct: 290 -----EESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEED 344
Query: 347 VNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQL 406
+ +C+L +E++ + A+ S + E FE T VC L LR
Sbjct: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVTE--------FETT--VCSLEELLRTE 394
Query: 407 Q 407
Q
Sbjct: 395 Q 395
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 62.4 bits (150), Expect = 2e-09
Identities = 64/301 (21%), Positives = 142/301 (47%), Gaps = 31/301 (10%)
Query: 134 SLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVS-AHFHEVL 192
+L EL + E L ++ +LQE L LAE+ +++ + +KR++ A F
Sbjct: 170 ALSLELYRNTITNEELKKKNAELQEKLRLAESEKS---EIQLNVKELKRKLERAKF---- 222
Query: 193 RLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLR 252
L ++ + +L QE+EL + ++E + +QE + L+EQ +
Sbjct: 223 -LLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER-----------LREQEGK 270
Query: 253 TASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERA 312
+E + RL+E+ ++LR L E+ L + ++ + +++ E+ +RE+
Sbjct: 271 MREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQE 330
Query: 313 VAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQ 372
RQ E+ WE+++Q Q QK + + E+ L+ + E +E+++ + + Q
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE-ERMREQEKMWEQEEKMQ 389
Query: 373 REISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEAR--TREPCPREKQR 430
E++ +R + ++ ++ +R Q ++Q + + +QE + ++ P +K++
Sbjct: 390 --------EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 441
Query: 431 L 431
L
Sbjct: 442 L 442
Score = 60.8 bits (146), Expect = 6e-09
Identities = 62/318 (19%), Positives = 153/318 (48%), Gaps = 24/318 (7%)
Query: 119 METSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEA--- 175
++T+ L E + L+E+ + + Q+E + R+ ++L+E G + E + + E
Sbjct: 227 VQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR 286
Query: 176 DHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQR 235
+ + RE E +L+++ + +++E + R +E+++ ++ L
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEE----KMREQEEKMWRQEERLWE 342
Query: 236 ANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEAR 295
E +++EQ + +E E+ RL+E+ E++R + E++ Q + R
Sbjct: 343 Q------EKQMREQEQKMRDQEERMWEQDERLREKEERMREQE-KMWEQEEKMQEEERIR 395
Query: 296 GSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVC 355
+++ E ++RE+ ++Q E WE++E+ ++Q+ ++ Q +EK+ +
Sbjct: 396 EREKKMREEEETMREQEEKMQKQEENMWEQEEK---EWQQQRLPEQ--KEKLWEQEKMQE 450
Query: 356 ELQKERDQAYSARDSAQREI---SQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPG 412
+ +K +Q RD Q E+ + + ++ +R Q ++ +Q ++R Q +++ +
Sbjct: 451 QEEKIWEQEEKIRD--QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 413 VLKQEARTREPCPREKQR 430
+ +Q+ R RE R +++
Sbjct: 509 MWEQDERLREKEERMREQ 526
Score = 56.6 bits (135), Expect = 1e-07
Identities = 53/264 (20%), Positives = 120/264 (45%), Gaps = 23/264 (8%)
Query: 218 RCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSL 277
R R +E + K+ Q+ + E + QEQ +T DQE E R++E +K+R
Sbjct: 515 RLREKEERMREQKKMWQQEEKMRE-EKKTQEQEKKTW-DQEEKMREEERMREREKKMRE- 571
Query: 278 TFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSK 337
E++++ + ++ + +++ E+ + E+ + Q E+ WE++E+ Q ++ K
Sbjct: 572 -----EEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDK 626
Query: 338 MACQ--LYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQ 395
M Q + E+ +Q Q ++ ++ ++ + + + + +++ +R Q ++ Q
Sbjct: 627 MQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQ 686
Query: 396 VCELRTQLRQLQAEPPGVLKQEAR-------------TREPCPREKQRLVRMHAICPRDD 442
++R Q +++ + + QE + RE R + + +M P +
Sbjct: 687 EEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHE 746
Query: 443 SDCSLVSSTESQLLSDLSATSSRE 466
CS S++L ++S T S E
Sbjct: 747 ERCSEPCLPPSKVLCNMSHTGSVE 770
Score = 43.9 bits (102), Expect = 8e-04
Identities = 59/290 (20%), Positives = 125/290 (43%), Gaps = 31/290 (10%)
Query: 159 HLGLAETRAEGLHQLEADHSRMKREVSA---------HFHEVLRLKDEMLSLSLHYSNAL 209
+LG ++ A LH ++R +SA + E L + + LSL L Y N +
Sbjct: 122 NLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLEL-YRNTI 180
Query: 210 QEKELAASRCRSLQEELYLLKQELQRANM-VSSCELELQEQS-----LRTASDQESGDEE 263
+EL LQE+L L + E + V + +L+ ++T + QE +
Sbjct: 181 TNEELKKKNAE-LQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQ 239
Query: 264 LNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYW 323
L+E+ +K+R + + E+ L E G +E E++ R++E+
Sbjct: 240 EEELREQEKKIRKQEEKMWRQ---EERLREQEGKMREQEEKM-----------RRQEKRL 285
Query: 324 EEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKD 383
E+E+ L + +K + RE+ +Q Q ++ ++ ++ + R+ + ++
Sbjct: 286 REQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 345
Query: 384 SLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVR 433
+R Q ++ DQ + Q +L+ + + +QE + +++ +R
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIR 395
Score = 36.6 bits (83), Expect = 0.12
Identities = 40/216 (18%), Positives = 96/216 (44%), Gaps = 32/216 (14%)
Query: 223 QEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLA 282
QEE++ ++++ R + E ++ EQ + ++ ++ R+ E++E+LR +
Sbjct: 465 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR 524
Query: 283 EKDILEQSLDEARGSR--QELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMAC 340
E+ + Q ++ R + QE ++ E+ ER RE+ + +E+
Sbjct: 525 EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE----------- 573
Query: 341 QLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEK--------------DSLR 386
++ RE+ +Q Q +++++ ++ + Q E Q EK D ++
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWE-----QEEKMQEQEEKMWEQEEKMWEQEEEDKMQ 628
Query: 387 RQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTRE 422
Q + +Q +++ Q ++ + + +QE + RE
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMRE 664
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 62.4 bits (150), Expect = 2e-09
Identities = 77/288 (26%), Positives = 126/288 (43%), Gaps = 27/288 (9%)
Query: 128 LAGAIGSLQEELNQEKG-QKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSA 186
LA +G E NQ+ Q E + + EHL + + E + E + VS
Sbjct: 112 LAARLGKALLERNQDMSRQYEQMHKELTDKLEHL--EQEKHELRRRFENREGEWEGRVSE 169
Query: 187 HFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELEL 246
+V +L+DE+ +H A +EK A + L E+ L +L RA+ V +L +
Sbjct: 170 LESDVKQLQDELERQQIHLREADREKSRAV---QELSEQNQRLLDQLSRASEVER-QLSM 225
Query: 247 QEQSLRT--ASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVER 304
Q +LR S ++ + RL+ +++ L+ E LE L L
Sbjct: 226 QVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRE---LEHRLSATLEENDLLQGT 282
Query: 305 IHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQA 364
+ L++R + ERQ + Q+ L+ Q+ +++C+ LQ +V EL +ER
Sbjct: 283 VEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCR-------QLQVKVEELTEERSLQ 335
Query: 365 YSARDSAQ--REISQSL------VEKDSLRRQVFELTDQVCELRTQLR 404
SA S EI QS+ E++ LR Q++E QV L + LR
Sbjct: 336 SSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLR 383
>gi|212276078 leucine rich repeat (in FLII) interacting protein 1
isoform 1 [Homo sapiens]
Length = 640
Score = 61.6 bits (148), Expect = 4e-09
Identities = 74/346 (21%), Positives = 153/346 (44%), Gaps = 38/346 (10%)
Query: 102 LVTGLQPDVDFSNFSGLMETSK-----LTECLAGAIGSLQE---ELNQEKGQKEVLLRRC 153
+V+ Q D + +NF ++T K L E LA + +E E +EK +L +
Sbjct: 303 MVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQF 362
Query: 154 QQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKE 213
+++E L E E + QL+ + RE+S E + KD+ + AL+ ++
Sbjct: 363 AEVKEALKQREEMLEEIRQLQQKQASSIREIS-DLQETIEWKDKKI-------GALERQK 414
Query: 214 LAASRCRS----LQEELYLLKQELQRANMVSSCELELQEQSLRTASD------QESGDEE 263
RS L+EE+ +LK+EL++ ++ + E+ ++ T ++ + EE
Sbjct: 415 EFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEE 474
Query: 264 LNRLKEENEKLRSLTFS--LAEKDILEQSLDEARGSRQE--LVERIHSLRERAVAAERQR 319
LN LK + + + E++ L + + + +G +E + ++ +LR E
Sbjct: 475 LNALKSTGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGT 534
Query: 320 EQY-WEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQS 378
+ + + + Q K +++ AL+ V L+ + + SA ++A++ +
Sbjct: 535 DMHVMDLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDEL 594
Query: 379 LVEKDSLRRQVFELTDQVCELRT-------QLRQLQAEPPGVLKQE 417
EK L+R++ D+ EL +L +++A +L Q+
Sbjct: 595 KAEKRKLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 640
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 61.6 bits (148), Expect = 4e-09
Identities = 63/324 (19%), Positives = 136/324 (41%), Gaps = 33/324 (10%)
Query: 129 AGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHF 188
A ++ L E+++ + K+ L + +L+ + + E L + +++ R R V F
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQF 1260
Query: 189 HEVLRLKDEMLSLSLH---------------YSNALQEKELAASRC----RSLQEELYLL 229
E+ + KDE + +H S+ ++EKE S+ ++L ++L L
Sbjct: 1261 SEI-KAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEEL 1319
Query: 230 KQELQRANMVSSCELELQEQSLRTAS--------DQESGDEELNRLKEENEKLRSL---- 277
K++++ + + S +QE+ E L + N ++
Sbjct: 1320 KRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKY 1379
Query: 278 -TFSLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKS 336
T ++ + LE++ + QE E + + + E+ +++ E E + ++S
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERS 1439
Query: 337 KMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQV 396
AC +K + E +++ D++ + ++AQ+E E +R E+ DQ+
Sbjct: 1440 HTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL 1499
Query: 397 CELRTQLRQLQAEPPGVLKQEART 420
LR + + LQ E + +Q A T
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAET 1523
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/384 (19%), Positives = 152/384 (39%), Gaps = 40/384 (10%)
Query: 132 IGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEV 191
+ LQ +++ E+ ++ ++LQ + E E H L A + + +++ E+
Sbjct: 1091 LSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI 1150
Query: 192 LRLKDEMLSLSLHYSNALQEKELAASRCR------SLQEELYLLKQELQRANMVSSCELE 245
+E + +++E + R +LQ E ++A+ V+ E
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVA----E 1206
Query: 246 LQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKD--------ILEQSLDEARGS 297
L EQ ++ ++E + LK E + + S +L++ +E E +
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAK 1266
Query: 298 RQELVERIHSLRERAVAAERQREQY---WEEKEQTLLQFQKSKMACQLYREKVNALQAQV 354
++ + IH L + + Q + EEKE + Q KSK AL Q+
Sbjct: 1267 DEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSK----------QALTQQL 1316
Query: 355 CELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAE----- 409
EL+++ ++ A+++ + S + D LR Q E + EL+ L + +E
Sbjct: 1317 EELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWR 1376
Query: 410 ---PPGVLKQEARTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRE 466
+++ E + QRL +S C+ + T+ +L ++ R+
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVE-DLMRD 1435
Query: 467 LVDSFRSSSPAPPSQQSLYKRVAE 490
L S + + Q++ K +AE
Sbjct: 1436 LERSHTACATLDKKQRNFDKVLAE 1459
Score = 54.7 bits (130), Expect = 4e-07
Identities = 62/285 (21%), Positives = 132/285 (46%), Gaps = 38/285 (13%)
Query: 134 SLQEELN----QEKGQKEVLL---RRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSA 186
SL +E N Q + + E L+ RC+ L + L E + + L + + M E+ A
Sbjct: 883 SLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVA 942
Query: 187 HFHEV----LRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSC 242
+ LK ++ L L + +EK ++ ++L EE+ L++ + + ++
Sbjct: 943 KKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISK---LTKE 999
Query: 243 ELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELV 302
+ LQE +T D + ++++N L + N KL T D LE SL++ + R +L
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQT------DDLEGSLEQEKKLRADLE 1053
Query: 303 ERIHSL-------RERAVAAERQREQYWEEKEQTLLQFQKSKMACQL---------YREK 346
L +E + E ++Q E+ ++ +F+ S++ ++ +++K
Sbjct: 1054 RAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKK--EFELSQLQAKIDDEQVHSLQFQKK 1111
Query: 347 VNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFE 391
+ LQA++ EL++E + ++ R +++ S E + + ++ E
Sbjct: 1112 IKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEE 1156
Score = 43.9 bits (102), Expect = 8e-04
Identities = 63/347 (18%), Positives = 139/347 (40%), Gaps = 40/347 (11%)
Query: 119 METSKLTECLAGAIGSLQEELNQEKGQKE--------VLLRRCQQLQEHLGLAETRAEGL 170
+E S++ L + EE+ Q K + VL + + L L + L
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626
Query: 171 HQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLK 230
+++E R+++ + ++ ++ LH +AL+ E + ++ LL
Sbjct: 1627 NEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLL 1686
Query: 231 QELQRANMVSSCELELQEQSLRTASDQE--SGDEELNRLKEENEKLRSLTFSLAEKDI-- 286
+EL+ + Q + R S+QE + + L +N L + T E DI
Sbjct: 1687 EELEEMKVALE-----QTERTRRLSEQELLDASDRVQLLHSQNTSLIN-TKKKLEADIAQ 1740
Query: 287 ----LEQSLDEARGSRQELVERIHSLRERAVAAERQR------EQYWEEKEQTLLQFQ-- 334
+E S+ E+R + ++ + I A ++++ E+ + EQT+ Q
Sbjct: 1741 CQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHR 1800
Query: 335 ---KSKMACQLYREKVNALQAQVCELQKERD-------QAYSARDSAQREISQSLVEKDS 384
++A + ++++ L+ +V EL+ E D +A +R++ + + +
Sbjct: 1801 LDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEE 1860
Query: 385 LRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRL 431
+ + L D V +L+ +++ + + +Q C R + L
Sbjct: 1861 DHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHEL 1907
Score = 40.8 bits (94), Expect = 0.006
Identities = 65/332 (19%), Positives = 135/332 (40%), Gaps = 54/332 (16%)
Query: 120 ETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSR 179
E +K +A A+ S + + + + Q E +LQ L A + E R
Sbjct: 1325 EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS--------EVAQWR 1376
Query: 180 MKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQE-------ELYLLKQE 232
K E A L++ L+ A + E A S+C SL++ E+ L ++
Sbjct: 1377 TKYETDA-IQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRD 1435
Query: 233 LQRANMVSSCELELQEQSLRTASD-QESGDEELNRLKEENEKLRSLTFSL-----AEKDI 286
L+R++ + + Q + ++ ++ DE L+ ++ RSL+ L A +++
Sbjct: 1436 LERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV 1495
Query: 287 LEQSLDEARGSRQELVERIHSLRERAVA-------AERQREQYWEEKEQTLLQFQKSKMA 339
++Q L+ R + L E I L E+ AE+ ++ +EK + ++ + +
Sbjct: 1496 VDQ-LETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGS 1554
Query: 340 CQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCEL 399
+ K+ +Q ++ +++ E D R+V E +++ +L
Sbjct: 1555 LEHEESKILRVQLELSQVKSELD------------------------RKVIEKDEEIEQL 1590
Query: 400 RTQLRQLQAEPPGVLKQEARTREPCPREKQRL 431
+ ++ VL E R+R R K+++
Sbjct: 1591 KRNSQRAAEALQSVLDAEIRSRNDALRLKKKM 1622
Score = 36.2 bits (82), Expect = 0.16
Identities = 35/134 (26%), Positives = 62/134 (46%), Gaps = 16/134 (11%)
Query: 137 EELNQEKGQKEV--LLRRCQQLQEHLGLAETRA----EGLHQLEADHSRMKREVSAHFHE 190
E+L + G+K++ L R ++L+ L + + R +G H+ E M +
Sbjct: 1805 EQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKN 1864
Query: 191 VLRLKDEMLSLSL---HYSNALQEKELAA----SRCRSLQEELYLLKQELQRANMVSSCE 243
+LRL+D + L Y +E E A SRCR +Q E L++ +RA++ S
Sbjct: 1865 ILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHE---LEEAAERADIAESQV 1921
Query: 244 LELQEQSLRTASDQ 257
+L+ +S S +
Sbjct: 1922 NKLRAKSRDVGSQK 1935
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 61.6 bits (148), Expect = 4e-09
Identities = 74/289 (25%), Positives = 129/289 (44%), Gaps = 51/289 (17%)
Query: 128 LAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREV--- 184
L G I LQ+ELN+E + E L L E L L ++ R+++E+
Sbjct: 718 LEGKITDLQKELNKEVEENEALREEVILLSE-----------LKSLPSEVERLRKEIQDK 766
Query: 185 SAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCEL 244
S H + KD++ S +H KE SR + L EE+ K +L A S+ +
Sbjct: 767 SEELHIITSEKDKLFSEVVH-------KE---SRVQGLLEEIGKTKDDL--ATTQSNYKS 814
Query: 245 ELQE-QSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGS------ 297
QE Q+ +T +++ + EENE++ +L+++ Q D + G+
Sbjct: 815 TDQEFQNFKTL--HMDFEQKYKMVLEENERMNQEIVNLSKE---AQKFDSSLGALKTELS 869
Query: 298 --RQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVC 355
QEL E+ ++ER E+ +EQ E ++ TL ++ K L EK+ +V
Sbjct: 870 YKTQELQEKTREVQERLNEMEQLKEQL-ENRDSTLQTVEREK---TLITEKLQQTLEEVK 925
Query: 356 ELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLR 404
L +E+D ++S Q +E+D L+ + + + + + QLR
Sbjct: 926 TLTQEKDDLKQLQESLQ-------IERDQLKSDIHDTVNMNIDTQEQLR 967
Score = 46.6 bits (109), Expect = 1e-04
Identities = 67/323 (20%), Positives = 134/323 (41%), Gaps = 36/323 (11%)
Query: 138 ELNQEKGQKEV-LLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKD 196
E N+ Q+ V L + Q+ LG +T L + REV +E+ +LK+
Sbjct: 838 EENERMNQEIVNLSKEAQKFDSSLGALKTE---LSYKTQELQEKTREVQERLNEMEQLKE 894
Query: 197 EMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSLRTASD 256
++ + +EK L + + EE+ L QE +L+ ++SL+ D
Sbjct: 895 QLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD--------DLKQLQESLQIERD 946
Query: 257 QESGD--EELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQELVERIHSLRERA-- 312
Q D + +N + E+LR+ SL + +++++ + E V R + E
Sbjct: 947 QLKSDIHDTVNMNIDTQEQLRNALESLKQH---QETINTLKSKISEEVSRNLHMEENTGE 1003
Query: 313 VAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQ 372
E Q++ +K+Q L + + ++ Q ++ L +E+++ Q
Sbjct: 1004 TKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNEL-------Q 1056
Query: 373 REISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLV 432
+ + + EK+ L+ + E + E + +LR L E LK++ +E +EK +
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDE----LKKQ---QEIVAQEKNHAI 1109
Query: 433 RMHAICPRDDSDCSLVSSTESQL 455
+ R C ++ E +L
Sbjct: 1110 KKEGELSR---TCDRLAEVEEKL 1129
Score = 46.6 bits (109), Expect = 1e-04
Identities = 53/276 (19%), Positives = 122/276 (44%), Gaps = 11/276 (3%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLA----ETRAEGLHQLEADHSRMKREVSAHFHE 190
LQ E +Q K + ++ + + +E L +A + + E +++L + S + E+S +
Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ 1513
Query: 191 VLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQS 250
+ + D++ + +E++ + +QE++ LKQ + S ++ +
Sbjct: 1514 LEAINDKLQNKIQEIYE--KEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKM 1571
Query: 251 LRTASDQESGDEELNRLKEENEKLRSLTFSL-AEKDILEQSLDEARGSRQELVERIHSLR 309
L + + EE+ + +E E+++ + +L E+D L+++ E +E E+ +
Sbjct: 1572 LELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFL 1631
Query: 310 ERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARD 369
+ E Q + E E QF+ K+ + E N Q+ E ++ +
Sbjct: 1632 KMTAVNETQEKMC--EIEHLKEQFETQKLNLENI-ETENIRLTQILHENLEEMRSVTKER 1688
Query: 370 SAQREISQSL-VEKDSLRRQVFELTDQVCELRTQLR 404
R + ++L VE+D L+ + E + E + +L+
Sbjct: 1689 DDLRSVEETLKVERDQLKENLRETITRDLEKQEELK 1724
Score = 45.4 bits (106), Expect = 3e-04
Identities = 66/330 (20%), Positives = 141/330 (42%), Gaps = 33/330 (10%)
Query: 118 LMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADH 177
L E +L E L +LQ + +K ++ + QQ E + + L QL+
Sbjct: 886 LNEMEQLKEQLENRDSTLQTV----EREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESL 941
Query: 178 SRMKREVSAHFHEVL--------RLKDEMLSLSLHYS--NALQEK-ELAASRCRSLQEEL 226
+ ++ + H+ + +L++ + SL H N L+ K SR ++E
Sbjct: 942 QIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENT 1001
Query: 227 YLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNR-------LKEENEKLRSLTF 279
K E Q+ + + +L+ ++ +T + +E + + ++E+NE + L
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLES 1061
Query: 280 SLAEKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMA 339
+AEK+ L+ L E + + +E LR ++Q+E +EK + + +
Sbjct: 1062 VIAEKEQLKTDLKE---NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRT 1118
Query: 340 CQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQV--FELT---- 393
C E L+ + +LQ+++ Q + ++ E+ + + E ++L+ ++ ELT
Sbjct: 1119 CDRLAEVEEKLKEKSQQLQEKQQQLLNVQEE-MSEMQKKINEIENLKNELKNKELTLEHM 1177
Query: 394 -DQVCELRTQLRQLQAEPPGVLKQEARTRE 422
+ EL +L + E + K+ +E
Sbjct: 1178 ETERLELAQKLNENYEEVKSITKERKVLKE 1207
Score = 44.3 bits (103), Expect = 6e-04
Identities = 74/328 (22%), Positives = 130/328 (39%), Gaps = 56/328 (17%)
Query: 181 KREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQELQRA-NMV 239
KRE + E L LK++M L+ Y + +L S+ + ++ L++ELQ A N +
Sbjct: 638 KRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEI 697
Query: 240 SS--------------CELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKD 285
+ C LEL+ + +D + +ELN+ EENE LR L+E
Sbjct: 698 TKLTSLIDGKVPKDLLCNLELEGK----ITDLQ---KELNKEVEENEALREEVILLSELK 750
Query: 286 ILEQSLDEARGSRQELVERIH-------SLRERAVAAERQREQYWEE------------- 325
L ++ R Q+ E +H L V E + + EE
Sbjct: 751 SLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQS 810
Query: 326 -KEQTLLQFQKSK-------MACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQ 377
+ T +FQ K ++ E+ + ++ L KE + S+ + + E+S
Sbjct: 811 NYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSY 870
Query: 378 SLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMHAI 437
E R+V E +++ +L+ QL + V +++ E + +Q L + +
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITE---KLQQTLEEVKTL 927
Query: 438 CPRDDSDCSLVSSTE---SQLLSDLSAT 462
D L S + QL SD+ T
Sbjct: 928 TQEKDDLKQLQESLQIERDQLKSDIHDT 955
Score = 44.3 bits (103), Expect = 6e-04
Identities = 62/308 (20%), Positives = 133/308 (43%), Gaps = 54/308 (17%)
Query: 103 VTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGL 162
++ +Q D++ SN + + K+ E L A L+E Q+E + + + E
Sbjct: 1751 ISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE-------QQETIDKLRGIVSEKTDK 1803
Query: 163 AETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSL 222
+ L A +E+ A+ H+++ LK ++ N Q+K
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV--------NETQKKV--------- 1846
Query: 223 QEELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLA 282
E+ LK++++ ++ S +L+ ++L A EE+ + +E + LR + +L
Sbjct: 1847 -SEMEQLKKQIKDQSLTLS---KLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902
Query: 283 -EKDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQ 341
E+D L++SL E + E+ + + + R + ++ K
Sbjct: 1903 LERDQLKESLQETKARDLEIQQELKTAR---------------------MLSKEHKETVD 1941
Query: 342 LYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRT 401
REK++ Q+ ++QK+ D+ ++D Q++I Q L +K+ +V E + +
Sbjct: 1942 KLREKISEKTIQISDIQKDLDK---SKDELQKKI-QELQKKELQLLRVKEDVNMSHKKIN 1997
Query: 402 QLRQLQAE 409
++ QL+ +
Sbjct: 1998 EMEQLKKQ 2005
Score = 42.7 bits (99), Expect = 0.002
Identities = 65/294 (22%), Positives = 119/294 (40%), Gaps = 39/294 (13%)
Query: 133 GSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVL 192
G L ++ +E L + QQLQE + + L ++ + S M+++++ E+
Sbjct: 1113 GELSRTCDRLAEVEEKLKEKSQQLQE-------KQQQLLNVQEEMSEMQKKIN----EIE 1161
Query: 193 RLKDEMLSLSLHYSNALQEK-ELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSL 251
LK+E+ + L + E+ ELA + +E + K+ + S E E
Sbjct: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRG 1221
Query: 252 RTASDQESG---DEELN----RLKEENEKLRSLTFSLAEKD---ILEQSLDEARGSRQEL 301
+ +G EEL LKE E + L S++EK I Q L+++ QE
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1281
Query: 302 VERIHSLRERAVAAERQREQYWEEKEQTLLQFQKS----------KMACQLYREKVNALQ 351
+ +H +E + E E LL Q + +M EK Q
Sbjct: 1282 IPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQ 1341
Query: 352 AQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQ 405
++ L KERD + +++ + V+ D L+ + E ++ E +++ Q
Sbjct: 1342 EEIKSLTKERDNLKTIKEALE-------VKHDQLKEHIRETLAKIQESQSKQEQ 1388
Score = 33.5 bits (75), Expect = 1.0
Identities = 58/267 (21%), Positives = 109/267 (40%), Gaps = 26/267 (9%)
Query: 173 LEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQE 232
LE H ++K H E L E S N ++EK+ ++ S E+
Sbjct: 1361 LEVKHDQLKE----HIRETLAKIQESQSKQEQSLN-MKEKDNETTKIVSEMEQFKPKDSA 1415
Query: 233 LQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLD 292
L R E+E+ S R QES DE + KE+++ R +E D L++++
Sbjct: 1416 LLRI------EIEMLGLSKRL---QESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK 1466
Query: 293 EARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVN-ALQ 351
E E E + + A +++E+ E L + + Q E +N LQ
Sbjct: 1467 EIVAKHLETEEEL----KVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQ 1522
Query: 352 AQVCELQKERDQ----AYSARDSAQREISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQ 407
++ E+ ++ +Q S E+ Q + + + + ++ EL +L++ Q
Sbjct: 1523 NKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQ 1582
Query: 408 AEPPGVLKQE---ARTREPCPREKQRL 431
E ++K++ R +E E+ +L
Sbjct: 1583 EEIQIMIKEKEEMKRVQEALQIERDQL 1609
Score = 32.0 bits (71), Expect = 3.0
Identities = 62/322 (19%), Positives = 132/322 (40%), Gaps = 58/322 (18%)
Query: 118 LMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADH 177
L +K+ E +I + + E +++ LL + Q LQ+ + L
Sbjct: 2177 LSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDL------- 2229
Query: 178 SRMKREVSAHFHEVLR--LKDEMLSLSLHYSNALQEKELAASRCRSLQE------ELYLL 229
++ + + H E+L+ + E S+ + L ++ + L+E ++ L
Sbjct: 2230 -KLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRK---EMTQFLEEWLNTRFDIEKL 2285
Query: 230 KQELQRAN------------MVSSCELELQEQSLRTASDQESGDEELNRLKEENEKL--- 274
K +Q+ N + + E E R+A+ + +++L LKE+NEKL
Sbjct: 2286 KNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKN 2345
Query: 275 -RSLTFSLAEKDILEQSLDEARG------SRQELVERIHSLRERAVAAERQREQYWEEKE 327
++L SLA + + + + + Q E+I L A+ KE
Sbjct: 2346 YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESA----MHKE 2401
Query: 328 QTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRR 387
+++ QK ++ + + LQA+V E K ++ +E Q L +K +L
Sbjct: 2402 SKIIKMQKE---LEVTNDIIAKLQAKVHESNKCLEKT--------KETIQVLQDKVALGA 2450
Query: 388 QVFELTDQVCELRTQLRQLQAE 409
+ ++ +++ +L+ +L ++ E
Sbjct: 2451 KPYK--EEIEDLKMKLVKIDLE 2470
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 61.6 bits (148), Expect = 4e-09
Identities = 105/469 (22%), Positives = 207/469 (44%), Gaps = 88/469 (18%)
Query: 38 RLTPYLRQAKVLCQLDEEE----VLHSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLK 93
R+T ++Q VL ++EE ++H ++T S M+ ++LL+ E L+
Sbjct: 1477 RVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQ--QKVELLRYES--------EKLQ 1526
Query: 94 FHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRC 153
N + +T L + SN G + QEE+ Q+ +
Sbjct: 1527 QENSILRNEITTLNEEDSISNLK------------LGTLNGSQEEMWQKTETVKQENAAV 1574
Query: 154 QQLQEHLG--LAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQE 211
Q++ E+L ++E + + QL+ +++ + ++ S + ++ L + + +E
Sbjct: 1575 QKMVENLKKQISELKIKN-QQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ-----KE 1628
Query: 212 KELAASRCRSLQEELYLLKQELQR-----ANMVSSCELELQEQSLRTASDQESGDEELNR 266
KE S ++E + LK+EL+R + +VSS E EL E ++T Q +E +
Sbjct: 1629 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ----QENHL 1684
Query: 267 LKEENEKLRSL-------TFSLAEKDIL---EQSLDEARGSRQEL---VERI--HSLRER 311
LK+E EK++ L F +L E+ L E +EL V+++ SL E
Sbjct: 1685 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEH 1744
Query: 312 AVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSA 371
+A +Q ++ WE + +L KS++ +EKV L+ V + + + S
Sbjct: 1745 RIATMKQEQKSWEHQSASL----KSQLVAS--QEKVQNLEDTVQNVNLQMSRMKS----- 1793
Query: 372 QREISQSLVEKDSLRRQVFELTDQVCEL--RTQLRQLQAEPPGVLKQEARTR----EPCP 425
++ + EK++L+++V L Q+ ++ ++ P G+ Q+ R +
Sbjct: 1794 --DLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLM 1851
Query: 426 REKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSS 474
E+Q+L + ++ ++V +T+++L T SRE V S+
Sbjct: 1852 NEEQQL-----LWQENERLQTMVQNTKAEL------THSREKVRQLESN 1889
Score = 48.9 bits (115), Expect = 2e-05
Identities = 82/346 (23%), Positives = 137/346 (39%), Gaps = 66/346 (19%)
Query: 125 TECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMK-RE 183
T L I L+ E+ + +GQ VL A A H+ E ++K E
Sbjct: 668 THTLEKQISDLKNEIAELQGQAAVLKE-----------AHHEATCRHEEEKKQLQVKLEE 716
Query: 184 VSAHFHEVLRLKDEM-LSLSLHYSNA--------LQEKELAASRCRSLQEEL-------- 226
H E LRL+ EM L L + A LQ + R L +EL
Sbjct: 717 EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQL 776
Query: 227 ------YLLKQELQRANMVSSCELELQEQ--------SLRTASDQESGDEELNRLKEENE 272
+ L++E R ++ + ELQE + RT+ + + ++ E E
Sbjct: 777 TSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCE 836
Query: 273 K-LRSLTFSLAE--KDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQT 329
L+SL + KD+ EQ +E Q E+ +E A A E +E EK +
Sbjct: 837 SALQSLEGRYRQELKDLQEQQREE---KSQWEFEKDELTQECAEAQELLKETLKREKTTS 893
Query: 330 LLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQV 389
L+ Q+ +M + Y+E +N++ + +L ++ + + E QSL
Sbjct: 894 LVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS-----ETQQSL---------- 938
Query: 390 FELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMH 435
L+DQ+ EL++ ++ E VL Q + + + +RL H
Sbjct: 939 --LSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 982
Score = 40.0 bits (92), Expect = 0.011
Identities = 93/433 (21%), Positives = 177/433 (40%), Gaps = 78/433 (18%)
Query: 120 ETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQ----EHL-GLAETRAEGLHQLE 174
E +LT+ A A L+E L +EK VL + + L+ EHL + R + L LE
Sbjct: 867 EKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 926
Query: 175 ADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKEL------AASRCRSLQEELYL 228
+ + + S L D++L L + L+E+E A+ + S + E
Sbjct: 927 DLRNVSETQQSL-------LSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLE 979
Query: 229 LKQELQRANMVSS-CELELQEQSLRTASDQESGD--EELNRLKEENEKLRSLTFSLAEKD 285
++ + +R M+S +E ++ +D+E + E++RL+ + ++++ T L+
Sbjct: 980 MEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLS--- 1036
Query: 286 ILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKS--------- 336
+ QS + G +E VE + A++ +Q EQ EE LL Q++
Sbjct: 1037 -MLQSGCQVIG--EEEVE-----GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENV 1088
Query: 337 KMACQLYR--EKVNALQ--------------------AQVCELQKERDQAYSARDSAQRE 374
KMA ++ R +++ L+ A+ E ++++ +R
Sbjct: 1089 KMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH 1148
Query: 375 ISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGV--LKQEARTREPCPREKQRLV 432
+ L E D +R T V ++ + +A G L+ TR K ++
Sbjct: 1149 VLSDL-EDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQIS 1207
Query: 433 RMHAICPRDDSDCSLVSSTESQLLSDLSATSSR-ELVDSFRSSSPAPPSQQSLYKRVAED 491
++ +DC S + LL D+S + ++++ +SP YK + ED
Sbjct: 1208 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYED 1260
Query: 492 FGEEPWSFSSCLE 504
E + CL+
Sbjct: 1261 VSRE----NDCLQ 1269
Score = 40.0 bits (92), Expect = 0.011
Identities = 72/343 (20%), Positives = 135/343 (39%), Gaps = 69/343 (20%)
Query: 134 SLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLR 193
S EE QEK + L RC+ L + LEA+ S +K + E
Sbjct: 1634 SALEEREQEKFNLKEELERCKVQSSTL---------VSSLEAELSEVKIQTHIVQQENHL 1684
Query: 194 LKDEMLSLS-LHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSL- 251
LKDE+ + LH L + + S S E+L LK++ + ++SC +L + SL
Sbjct: 1685 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKL--LKEKEALSEELNSCVDKLAKSSLL 1742
Query: 252 --RTAS---DQESGDEELNRLKEE----NEKLRSLTFSLAEKDI----LEQSLDEARGSR 298
R A+ +Q+S + + LK + EK+++L ++ ++ ++ L + +
Sbjct: 1743 EHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEK 1802
Query: 299 QELVERIHSLRERAVAA--------------------------------ERQREQYWEEK 326
+ L + + SL ++ A +++ W+E
Sbjct: 1803 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1862
Query: 327 EQTLLQFQKSKMACQLYREKVNALQAQVCELQKER-------DQAYSARDSAQREISQSL 379
E+ Q +K REKV L++ + ++ + + S +RE Q
Sbjct: 1863 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQ 1922
Query: 380 VEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTRE 422
E+ R+V Q+ L +L + E G+ K++ + E
Sbjct: 1923 KEQSPANRKV----SQMNSLEQELETIHLENEGLKKKQVKLDE 1961
Score = 37.7 bits (86), Expect = 0.055
Identities = 58/268 (21%), Positives = 101/268 (37%), Gaps = 41/268 (15%)
Query: 165 TRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQE 224
TR L LE D R + +K E S+ + L+ E + L+
Sbjct: 1145 TRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKN 1204
Query: 225 ELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLA-E 283
++ L+++L E ++ L S + + L R+ E + K + L ++ E
Sbjct: 1205 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE 1264
Query: 284 KDILEQSL-------DEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKS 336
D L++ L DEA + +EL + L++ + EE +T L +KS
Sbjct: 1265 NDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL--------KKMEEVTETFLSLEKS 1316
Query: 337 KMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQV 396
++ E++N L ++ Q +EK L+ V + D
Sbjct: 1317 YDEVKIENEELNVLVLRL----------------------QGKIEK--LQESVVQRCD-C 1351
Query: 397 CELRTQLRQLQAEPPGVLKQEARTREPC 424
C L L+ EP G + Q +T E C
Sbjct: 1352 CLWEASLENLEIEPDGNILQLNQTLEEC 1379
Score = 37.4 bits (85), Expect = 0.071
Identities = 62/348 (17%), Positives = 147/348 (42%), Gaps = 51/348 (14%)
Query: 137 EELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKD 196
+EL ++ ++ +L + + + H E +H L+ S M+++V +E +L+
Sbjct: 1468 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1527
Query: 197 EMLSLSLHYSNALQEKELAASRCRSL---QEELYLLKQELQRAN------------MVSS 241
E L + +E ++ + +L QEE++ + +++ N +S
Sbjct: 1528 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1587
Query: 242 CELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQEL 301
+++ Q+ L + + +L+E N++L + EK+ +L+E + L
Sbjct: 1588 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQEKFNL 1646
Query: 302 VERIHSLRER---------AVAAERQREQYWEEKEQTLLQFQKSKMACQLYR-------- 344
E + + + A +E + + + ++E LL+ + KM QL+R
Sbjct: 1647 KEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-QLHRCPDLSDFQ 1705
Query: 345 EKVNALQAQVCELQKERDQAYSARDSAQREISQSLV----------EKDSLRRQVFELTD 394
+K++++ + +L KE++ +S ++++S + E+ S Q L
Sbjct: 1706 QKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKS 1765
Query: 395 QVCELRTQLRQLQAEPPGVLKQEAR-------TREPCPREKQRLVRMH 435
Q+ + +++ L+ V Q +R T++ KQ ++ +H
Sbjct: 1766 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLH 1813
Score = 32.3 bits (72), Expect = 2.3
Identities = 67/290 (23%), Positives = 121/290 (41%), Gaps = 37/290 (12%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLA---------ETRAEGLHQLEADHSRMKRE-V 184
++ +L + +KE L + L + L A T GLH + S K + +
Sbjct: 1791 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1850
Query: 185 SAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQ------------- 231
++L ++E L + + A EL SR + Q E LL +
Sbjct: 1851 MNEEQQLLWQENERLQTMVQNTKA----ELTHSREKVRQLESNLLPKHQKHLNPSGTMNP 1906
Query: 232 -ELQRANMVSSCELELQEQSL--RTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILE 288
E ++ ++ C+ +EQS R S S ++EL + ENE L+ L E+ +
Sbjct: 1907 TEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEM 1966
Query: 289 QSL-DEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKV 347
Q L A S + L+++A REQ+ + + Q LLQ ++ Q +E++
Sbjct: 1967 QHLRSTATPSPSPHAWDLQLLQQQACPMV-PREQFLQLQRQ-LLQAERIN---QHLQEEL 2021
Query: 348 NALQAQVCELQKERDQAYSARDSAQREISQSL-VEKDSLRRQVFELTDQV 396
++ Q ++Q + + E+ Q L + K L+ +V +L +QV
Sbjct: 2022 ENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2071
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 61.6 bits (148), Expect = 4e-09
Identities = 105/469 (22%), Positives = 207/469 (44%), Gaps = 88/469 (18%)
Query: 38 RLTPYLRQAKVLCQLDEEE----VLHSPRLTNSAMRAGHLLDLLKTRGKNGAIAFLESLK 93
R+T ++Q VL ++EE ++H ++T S M+ ++LL+ E L+
Sbjct: 1471 RVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQ--QKVELLRYES--------EKLQ 1520
Query: 94 FHNPDVYTLVTGLQPDVDFSNFSGLMETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRC 153
N + +T L + SN G + QEE+ Q+ +
Sbjct: 1521 QENSILRNEITTLNEEDSISNLK------------LGTLNGSQEEMWQKTETVKQENAAV 1568
Query: 154 QQLQEHLG--LAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQE 211
Q++ E+L ++E + + QL+ +++ + ++ S + ++ L + + +E
Sbjct: 1569 QKMVENLKKQISELKIKN-QQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQ-----KE 1622
Query: 212 KELAASRCRSLQEELYLLKQELQR-----ANMVSSCELELQEQSLRTASDQESGDEELNR 266
KE S ++E + LK+EL+R + +VSS E EL E ++T Q +E +
Sbjct: 1623 KEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ----QENHL 1678
Query: 267 LKEENEKLRSL-------TFSLAEKDIL---EQSLDEARGSRQEL---VERI--HSLRER 311
LK+E EK++ L F +L E+ L E +EL V+++ SL E
Sbjct: 1679 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEH 1738
Query: 312 AVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSA 371
+A +Q ++ WE + +L KS++ +EKV L+ V + + + S
Sbjct: 1739 RIATMKQEQKSWEHQSASL----KSQLVAS--QEKVQNLEDTVQNVNLQMSRMKS----- 1787
Query: 372 QREISQSLVEKDSLRRQVFELTDQVCEL--RTQLRQLQAEPPGVLKQEARTR----EPCP 425
++ + EK++L+++V L Q+ ++ ++ P G+ Q+ R +
Sbjct: 1788 --DLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLM 1845
Query: 426 REKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSS 474
E+Q+L + ++ ++V +T+++L T SRE V S+
Sbjct: 1846 NEEQQL-----LWQENERLQTMVQNTKAEL------THSREKVRQLESN 1883
Score = 48.9 bits (115), Expect = 2e-05
Identities = 82/346 (23%), Positives = 137/346 (39%), Gaps = 66/346 (19%)
Query: 125 TECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMK-RE 183
T L I L+ E+ + +GQ VL A A H+ E ++K E
Sbjct: 662 THTLEKQISDLKNEIAELQGQAAVLKE-----------AHHEATCRHEEEKKQLQVKLEE 710
Query: 184 VSAHFHEVLRLKDEM-LSLSLHYSNA--------LQEKELAASRCRSLQEEL-------- 226
H E LRL+ EM L L + A LQ + R L +EL
Sbjct: 711 EKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGLTQELEQFHQEQL 770
Query: 227 ------YLLKQELQRANMVSSCELELQEQ--------SLRTASDQESGDEELNRLKEENE 272
+ L++E R ++ + ELQE + RT+ + + ++ E E
Sbjct: 771 TSLVEKHTLEKEELRKELLEKHQRELQEGREKMETECNRRTSQIEAQFQSDCQKVTERCE 830
Query: 273 K-LRSLTFSLAE--KDILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQT 329
L+SL + KD+ EQ +E Q E+ +E A A E +E EK +
Sbjct: 831 SALQSLEGRYRQELKDLQEQQREE---KSQWEFEKDELTQECAEAQELLKETLKREKTTS 887
Query: 330 LLQFQKSKMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQV 389
L+ Q+ +M + Y+E +N++ + +L ++ + + E QSL
Sbjct: 888 LVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVS-----ETQQSL---------- 932
Query: 390 FELTDQVCELRTQLRQLQAEPPGVLKQEARTREPCPREKQRLVRMH 435
L+DQ+ EL++ ++ E VL Q + + + +RL H
Sbjct: 933 --LSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEH 976
Score = 40.0 bits (92), Expect = 0.011
Identities = 93/433 (21%), Positives = 177/433 (40%), Gaps = 78/433 (18%)
Query: 120 ETSKLTECLAGAIGSLQEELNQEKGQKEVLLRRCQQLQ----EHL-GLAETRAEGLHQLE 174
E +LT+ A A L+E L +EK VL + + L+ EHL + R + L LE
Sbjct: 861 EKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLE 920
Query: 175 ADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKEL------AASRCRSLQEELYL 228
+ + + S L D++L L + L+E+E A+ + S + E
Sbjct: 921 DLRNVSETQQSL-------LSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLE 973
Query: 229 LKQELQRANMVSS-CELELQEQSLRTASDQESGD--EELNRLKEENEKLRSLTFSLAEKD 285
++ + +R M+S +E ++ +D+E + E++RL+ + ++++ T L+
Sbjct: 974 MEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLS--- 1030
Query: 286 ILEQSLDEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKS--------- 336
+ QS + G +E VE + A++ +Q EQ EE LL Q++
Sbjct: 1031 -MLQSGCQVIG--EEEVE-----GDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENV 1082
Query: 337 KMACQLYR--EKVNALQ--------------------AQVCELQKERDQAYSARDSAQRE 374
KMA ++ R +++ L+ A+ E ++++ +R
Sbjct: 1083 KMATEISRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRH 1142
Query: 375 ISQSLVEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGV--LKQEARTREPCPREKQRLV 432
+ L E D +R T V ++ + +A G L+ TR K ++
Sbjct: 1143 VLSDL-EDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQIS 1201
Query: 433 RMHAICPRDDSDCSLVSSTESQLLSDLSATSSR-ELVDSFRSSSPAPPSQQSLYKRVAED 491
++ +DC S + LL D+S + ++++ +SP YK + ED
Sbjct: 1202 QLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPK-------YKLLYED 1254
Query: 492 FGEEPWSFSSCLE 504
E + CL+
Sbjct: 1255 VSRE----NDCLQ 1263
Score = 40.0 bits (92), Expect = 0.011
Identities = 72/343 (20%), Positives = 135/343 (39%), Gaps = 69/343 (20%)
Query: 134 SLQEELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLR 193
S EE QEK + L RC+ L + LEA+ S +K + E
Sbjct: 1628 SALEEREQEKFNLKEELERCKVQSSTL---------VSSLEAELSEVKIQTHIVQQENHL 1678
Query: 194 LKDEMLSLS-LHYSNALQEKELAASRCRSLQEELYLLKQELQRANMVSSCELELQEQSL- 251
LKDE+ + LH L + + S S E+L LK++ + ++SC +L + SL
Sbjct: 1679 LKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKL--LKEKEALSEELNSCVDKLAKSSLL 1736
Query: 252 --RTAS---DQESGDEELNRLKEE----NEKLRSLTFSLAEKDI----LEQSLDEARGSR 298
R A+ +Q+S + + LK + EK+++L ++ ++ ++ L + +
Sbjct: 1737 EHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEK 1796
Query: 299 QELVERIHSLRERAVAA--------------------------------ERQREQYWEEK 326
+ L + + SL ++ A +++ W+E
Sbjct: 1797 EALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHLMNEEQQLLWQEN 1856
Query: 327 EQTLLQFQKSKMACQLYREKVNALQAQVCELQKER-------DQAYSARDSAQREISQSL 379
E+ Q +K REKV L++ + ++ + + S +RE Q
Sbjct: 1857 ERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNPTEQEKLSLKRECDQFQ 1916
Query: 380 VEKDSLRRQVFELTDQVCELRTQLRQLQAEPPGVLKQEARTRE 422
E+ R+V Q+ L +L + E G+ K++ + E
Sbjct: 1917 KEQSPANRKV----SQMNSLEQELETIHLENEGLKKKQVKLDE 1955
Score = 37.7 bits (86), Expect = 0.055
Identities = 58/268 (21%), Positives = 101/268 (37%), Gaps = 41/268 (15%)
Query: 165 TRAEGLHQLEADHSRMKREVSAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQE 224
TR L LE D R + +K E S+ + L+ E + L+
Sbjct: 1139 TRRHVLSDLEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKN 1198
Query: 225 ELYLLKQELQRANMVSSCELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLA-E 283
++ L+++L E ++ L S + + L R+ E + K + L ++ E
Sbjct: 1199 QISQLQEQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRE 1258
Query: 284 KDILEQSL-------DEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKS 336
D L++ L DEA + +EL + L++ + EE +T L +KS
Sbjct: 1259 NDCLQEELRMMETRYDEALENNKELTAEVFRLQDEL--------KKMEEVTETFLSLEKS 1310
Query: 337 KMACQLYREKVNALQAQVCELQKERDQAYSARDSAQREISQSLVEKDSLRRQVFELTDQV 396
++ E++N L ++ Q +EK L+ V + D
Sbjct: 1311 YDEVKIENEELNVLVLRL----------------------QGKIEK--LQESVVQRCD-C 1345
Query: 397 CELRTQLRQLQAEPPGVLKQEARTREPC 424
C L L+ EP G + Q +T E C
Sbjct: 1346 CLWEASLENLEIEPDGNILQLNQTLEEC 1373
Score = 37.4 bits (85), Expect = 0.071
Identities = 62/348 (17%), Positives = 147/348 (42%), Gaps = 51/348 (14%)
Query: 137 EELNQEKGQKEVLLRRCQQLQEHLGLAETRAEGLHQLEADHSRMKREVSAHFHEVLRLKD 196
+EL ++ ++ +L + + + H E +H L+ S M+++V +E +L+
Sbjct: 1462 QELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEMQQKVELLRYESEKLQQ 1521
Query: 197 EMLSLSLHYSNALQEKELAASRCRSL---QEELYLLKQELQRAN------------MVSS 241
E L + +E ++ + +L QEE++ + +++ N +S
Sbjct: 1522 ENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISE 1581
Query: 242 CELELQEQSLRTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILEQSLDEARGSRQEL 301
+++ Q+ L + + +L+E N++L + EK+ +L+E + L
Sbjct: 1582 LKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEM-LCQKEKEPGNSALEEREQEKFNL 1640
Query: 302 VERIHSLRER---------AVAAERQREQYWEEKEQTLLQFQKSKMACQLYR-------- 344
E + + + A +E + + + ++E LL+ + KM QL+R
Sbjct: 1641 KEELERCKVQSSTLVSSLEAELSEVKIQTHIVQQENHLLKDELEKMK-QLHRCPDLSDFQ 1699
Query: 345 EKVNALQAQVCELQKERDQAYSARDSAQREISQSLV----------EKDSLRRQVFELTD 394
+K++++ + +L KE++ +S ++++S + E+ S Q L
Sbjct: 1700 QKISSVLSYNEKLLKEKEALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWEHQSASLKS 1759
Query: 395 QVCELRTQLRQLQAEPPGVLKQEAR-------TREPCPREKQRLVRMH 435
Q+ + +++ L+ V Q +R T++ KQ ++ +H
Sbjct: 1760 QLVASQEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLH 1807
Score = 32.3 bits (72), Expect = 2.3
Identities = 67/290 (23%), Positives = 121/290 (41%), Gaps = 37/290 (12%)
Query: 135 LQEELNQEKGQKEVLLRRCQQLQEHLGLA---------ETRAEGLHQLEADHSRMKRE-V 184
++ +L + +KE L + L + L A T GLH + S K + +
Sbjct: 1785 MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLDHL 1844
Query: 185 SAHFHEVLRLKDEMLSLSLHYSNALQEKELAASRCRSLQEELYLLKQ------------- 231
++L ++E L + + A EL SR + Q E LL +
Sbjct: 1845 MNEEQQLLWQENERLQTMVQNTKA----ELTHSREKVRQLESNLLPKHQKHLNPSGTMNP 1900
Query: 232 -ELQRANMVSSCELELQEQSL--RTASDQESGDEELNRLKEENEKLRSLTFSLAEKDILE 288
E ++ ++ C+ +EQS R S S ++EL + ENE L+ L E+ +
Sbjct: 1901 TEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLMEM 1960
Query: 289 QSL-DEARGSRQELVERIHSLRERAVAAERQREQYWEEKEQTLLQFQKSKMACQLYREKV 347
Q L A S + L+++A REQ+ + + Q LLQ ++ Q +E++
Sbjct: 1961 QHLRSTATPSPSPHAWDLQLLQQQACPMV-PREQFLQLQRQ-LLQAERIN---QHLQEEL 2015
Query: 348 NALQAQVCELQKERDQAYSARDSAQREISQSL-VEKDSLRRQVFELTDQV 396
++ Q ++Q + + E+ Q L + K L+ +V +L +QV
Sbjct: 2016 ENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQV 2065
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,125,703
Number of Sequences: 37866
Number of extensions: 1773103
Number of successful extensions: 11875
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 867
Number of HSP's that attempted gapping in prelim test: 7168
Number of HSP's gapped (non-prelim): 3260
length of query: 1004
length of database: 18,247,518
effective HSP length: 112
effective length of query: 892
effective length of database: 14,006,526
effective search space: 12493821192
effective search space used: 12493821192
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.