Guide to the Human Genome
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Search of human proteins with 13129108

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13129108 melanophilin isoform 1 [Homo sapiens]
         (600 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13129108 melanophilin isoform 1 [Homo sapiens]                    1198   0.0  
gi|109826351 melanophilin isoform 2 [Homo sapiens]                   1128   0.0  
gi|59853352 myosin VIIA and Rab interacting protein [Homo sapiens]    171   1e-42
gi|193804862 synaptotagmin-like 4 [Homo sapiens]                       74   4e-13
gi|193804860 synaptotagmin-like 4 [Homo sapiens]                       74   4e-13
gi|110227631 synaptotagmin-like 3 [Homo sapiens]                       68   2e-11
gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]             66   8e-11
gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]             66   8e-11
gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]              66   8e-11
gi|194272142 myosin IXB isoform 2 [Homo sapiens]                       50   6e-06
gi|33356170 myosin IXB isoform 1 [Homo sapiens]                        50   6e-06
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]             47   5e-05
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]              47   5e-05
gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]             45   2e-04
gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]              44   3e-04
gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]             44   3e-04
gi|60097902 filaggrin [Homo sapiens]                                   42   0.002
gi|238859655 tetratricopeptide repeat domain 31 [Homo sapiens]         41   0.003
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     41   0.003
gi|48255931 hepatoma-derived growth factor-related protein 2 iso...    41   0.004
gi|14249158 hepatoma-derived growth factor-related protein 2 iso...    41   0.004
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu...    40   0.006
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre...    40   0.006
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    40   0.008
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    40   0.008
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    40   0.008
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ...    40   0.008
gi|194328736 PHD finger protein 10 isoform b [Homo sapiens]            40   0.008
gi|194328734 PHD finger protein 10 isoform a [Homo sapiens]            40   0.008
gi|5902064 rabphilin 3A-like (without C2 domains) [Homo sapiens]       40   0.008

>gi|13129108 melanophilin isoform 1 [Homo sapiens]
          Length = 600

 Score = 1198 bits (3100), Expect = 0.0
 Identities = 600/600 (100%), Positives = 600/600 (100%)

Query: 1   MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
           MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN
Sbjct: 1   MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60

Query: 61  ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
           ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW
Sbjct: 61  ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120

Query: 121 YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ 180
           YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ
Sbjct: 121 YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ 180

Query: 181 PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK 240
           PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK
Sbjct: 181 PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK 240

Query: 241 AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN 300
           AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN
Sbjct: 241 AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN 300

Query: 301 EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQIFELNKHISAVECLLTYLEN 360
           EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQIFELNKHISAVECLLTYLEN
Sbjct: 301 EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQIFELNKHISAVECLLTYLEN 360

Query: 361 TVVPPLAKGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS 420
           TVVPPLAKGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS
Sbjct: 361 TVVPPLAKGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS 420

Query: 421 VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE 480
           VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE
Sbjct: 421 VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE 480

Query: 481 SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA 540
           SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA
Sbjct: 481 SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA 540

Query: 541 MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS 600
           MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS
Sbjct: 541 MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS 600


>gi|109826351 melanophilin isoform 2 [Homo sapiens]
          Length = 572

 Score = 1128 bits (2918), Expect = 0.0
 Identities = 572/600 (95%), Positives = 572/600 (95%), Gaps = 28/600 (4%)

Query: 1   MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
           MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN
Sbjct: 1   MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60

Query: 61  ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
           ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW
Sbjct: 61  ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120

Query: 121 YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ 180
           YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ
Sbjct: 121 YYEHVKARFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQ 180

Query: 181 PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK 240
           PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK
Sbjct: 181 PFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHK 240

Query: 241 AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN 300
           AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN
Sbjct: 241 AEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRN 300

Query: 301 EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQIFELNKHISAVECLLTYLEN 360
           EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQ                    
Sbjct: 301 EQLPLQYLADVDTSDEESIRAHVMASHHSKRRGRASSESQ-------------------- 340

Query: 361 TVVPPLAKGLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS 420
                   GLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS
Sbjct: 341 --------GLGAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKS 392

Query: 421 VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE 480
           VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE
Sbjct: 393 VGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE 452

Query: 481 SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA 540
           SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA
Sbjct: 453 SEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA 512

Query: 541 MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS 600
           MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS
Sbjct: 513 MAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYRGSLTQRNPNARKGMASHTFAKPVVAHQS 572


>gi|59853352 myosin VIIA and Rab interacting protein [Homo sapiens]
          Length = 859

 Score =  171 bits (434), Expect = 1e-42
 Identities = 110/291 (37%), Positives = 159/291 (54%), Gaps = 16/291 (5%)

Query: 1   MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
           MG+KLDLS LTD+E +HVL+VVQRDF+LR+KEEERL  LK K+ +E SK  +LS      
Sbjct: 1   MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV 60

Query: 61  ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
           E  C RC  P+  LVN+KRQC +C    CKSC      E+ W+C  C  AR+++  SLEW
Sbjct: 61  EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW 120

Query: 121 YYEHVKARFKRFGSAKVIRSLH--GRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQ 178
           +Y +VK+RFKRFGSAKV+++L+   RL+ GA  +++      +S+  +E    GS++   
Sbjct: 121 FYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLF-ESNLENEGSISGSDSTFY 179

Query: 179 AQPFGSKKKRLLSVH-DFDFEGDSDDSTQPQGHSLHLSSVPEA---RDSPQSLTDESCSE 234
            Q  G      L+V      E   +  ++ + +   L    EA   RD  + LT+E  + 
Sbjct: 180 RQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATT 239

Query: 235 ------KAAPHKAEGLEEADTG---ASGCHSHPEEQPTSISPSRHGALAEL 276
                 +    K+E   E + G      C +   ++ TS SP  + A A L
Sbjct: 240 ILQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAAL 290



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 40/133 (30%), Positives = 66/133 (49%), Gaps = 16/133 (12%)

Query: 454 YNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLP 513
           ++ T +  L++LED+VA  A++V  AE ++SDIESRI+AL  AGL + P  +  R+ +  
Sbjct: 726 HSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTRRRDQK 785

Query: 514 IFLPRVAGKLGKRPEDPNADPS-SEAKAMAVPYLLRRKFSNSLKSQGKDDDSFDRKSVYR 572
                      +R +    D S  + + +  P +   K   S  +  K   +F+   + +
Sbjct: 786 -----------QRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSVTTIK---TFNHNFILQ 831

Query: 573 GSLTQRNPNARKG 585
           GS T R    RKG
Sbjct: 832 GSSTNRT-KERKG 843


>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 8/142 (5%)

Query: 1   MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKG---KIKKESSKRELLSDTA 57
           M + LDLS L++EE   +L V+QRD ++R+ +E+R+  LK    +IK++ +KR     + 
Sbjct: 1   MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKR----GSQ 56

Query: 58  HLNETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGS 117
           H ++  CARC +    L      C  C    C+ C R+      W C  C     +K  +
Sbjct: 57  HYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDC-RIQESNGTWRCKVCAKEIELKKAT 115

Query: 118 LEWYYEHVKARFKRFGSAKVIR 139
            +W+Y+    RF     +++IR
Sbjct: 116 GDWFYDQKVNRFAYRTGSEIIR 137


>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
          Length = 671

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 43/142 (30%), Positives = 72/142 (50%), Gaps = 8/142 (5%)

Query: 1   MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKG---KIKKESSKRELLSDTA 57
           M + LDLS L++EE   +L V+QRD ++R+ +E+R+  LK    +IK++ +KR     + 
Sbjct: 1   MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKR----GSQ 56

Query: 58  HLNETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGS 117
           H ++  CARC +    L      C  C    C+ C R+      W C  C     +K  +
Sbjct: 57  HYSDRTCARCQESLGRLSPKTNTCRGCNHLVCRDC-RIQESNGTWRCKVCAKEIELKKAT 115

Query: 118 LEWYYEHVKARFKRFGSAKVIR 139
            +W+Y+    RF     +++IR
Sbjct: 116 GDWFYDQKVNRFAYRTGSEIIR 137


>gi|110227631 synaptotagmin-like 3 [Homo sapiens]
          Length = 542

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 43/138 (31%), Positives = 63/138 (45%), Gaps = 1/138 (0%)

Query: 1   MGKKLDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLN 60
           M +++DLS L + E + +L+V+ RD  ++  EEER   LK  ++    K    +D  H  
Sbjct: 1   MAQEIDLSALKELEREAILQVLYRDQAVQNTEEERTRKLKTHLQHLRWKGAKNTDWEH-K 59

Query: 61  ETHCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEW 120
           E  CARC Q    L++    C  C    C  C         W C  C   R VKI + EW
Sbjct: 60  EKCCARCQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEW 119

Query: 121 YYEHVKARFKRFGSAKVI 138
           +YE    +F   G  + +
Sbjct: 120 FYEERAKKFPTGGKHETV 137


>gi|254039650 synaptotagmin-like 5 isoform 1 [Homo sapiens]
          Length = 730

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 16/191 (8%)

Query: 5   LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKI---KKESSKRELLSDTAHLNE 61
           ++LS L D E + +L V++RD  L++ E++R+  LK ++   K+ S K +  +       
Sbjct: 8   INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRV---- 63

Query: 62  THCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWY 121
             C  C +   L+ +    C  C L  C+ C RV      W C  C     ++I + EW+
Sbjct: 64  --CVHCHRNLGLIFDRGDPCQACSLRVCREC-RVAGPNGSWKCTVCDKIAQLRIITGEWF 120

Query: 122 YEHVKARFKRFG--SAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQA 179
           +E    RFK+       V+R    R   GA      E+   D++++D     G +A    
Sbjct: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHD- 179

Query: 180 QPFGSKKKRLL 190
              G K+K  L
Sbjct: 180 ---GPKRKGFL 187


>gi|254039648 synaptotagmin-like 5 isoform 2 [Homo sapiens]
          Length = 752

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 16/191 (8%)

Query: 5   LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKI---KKESSKRELLSDTAHLNE 61
           ++LS L D E + +L V++RD  L++ E++R+  LK ++   K+ S K +  +       
Sbjct: 8   INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRV---- 63

Query: 62  THCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWY 121
             C  C +   L+ +    C  C L  C+ C RV      W C  C     ++I + EW+
Sbjct: 64  --CVHCHRNLGLIFDRGDPCQACSLRVCREC-RVAGPNGSWKCTVCDKIAQLRIITGEWF 120

Query: 122 YEHVKARFKRFG--SAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQA 179
           +E    RFK+       V+R    R   GA      E+   D++++D     G +A    
Sbjct: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHD- 179

Query: 180 QPFGSKKKRLL 190
              G K+K  L
Sbjct: 180 ---GPKRKGFL 187


>gi|20270305 synaptotagmin-like 5 isoform 1 [Homo sapiens]
          Length = 730

 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 16/191 (8%)

Query: 5   LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKI---KKESSKRELLSDTAHLNE 61
           ++LS L D E + +L V++RD  L++ E++R+  LK ++   K+ S K +  +       
Sbjct: 8   INLSFLLDHEKEMILGVLKRDEYLKKVEDKRIRKLKNELLEAKRRSGKTQQEASRV---- 63

Query: 62  THCARCLQPYQLLVNSKRQCLECGLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWY 121
             C  C +   L+ +    C  C L  C+ C RV      W C  C     ++I + EW+
Sbjct: 64  --CVHCHRNLGLIFDRGDPCQACSLRVCREC-RVAGPNGSWKCTVCDKIAQLRIITGEWF 120

Query: 122 YEHVKARFKRFG--SAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQA 179
           +E    RFK+       V+R    R   GA      E+   D++++D     G +A    
Sbjct: 121 FEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQSQEQTRQDAEKSDTSPVAGKKASHD- 179

Query: 180 QPFGSKKKRLL 190
              G K+K  L
Sbjct: 180 ---GPKRKGFL 187


>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
          Length = 2022

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 56/259 (21%), Positives = 106/259 (40%), Gaps = 23/259 (8%)

Query: 10   LTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQ 69
            L  ++AQ   EV+    +  + ++   +  K K+  + ++R+ L +T H         LQ
Sbjct: 905  LLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQ 964

Query: 70   PYQLLVNSKRQCLEC--GLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKA 127
             +  +V  +R  L+      T ++C R +   +         A V    S   Y++    
Sbjct: 965  SWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRALERTQ---AAVYLQASWRGYWQRKLY 1021

Query: 128  RFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTD--EDGEPGSEAQAQAQPFGSK 185
            R ++    ++     G LQ  +  ++ISE++  +  + +  E    G+E   Q Q  G +
Sbjct: 1022 RHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQ 1081

Query: 186  KKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLE 245
            +              ++   +P     HL+S PE + S +S  + S  EK AP   + L 
Sbjct: 1082 QV-------------AEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLP 1128

Query: 246  EADTGASGCHSHPEEQPTS 264
               T A+  H   E+ P+S
Sbjct: 1129 PQKTVAAESH---EKVPSS 1144


>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
          Length = 2157

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 56/259 (21%), Positives = 106/259 (40%), Gaps = 23/259 (8%)

Query: 10   LTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQ 69
            L  ++AQ   EV+    +  + ++   +  K K+  + ++R+ L +T H         LQ
Sbjct: 905  LLPKDAQPCREVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQ 964

Query: 70   PYQLLVNSKRQCLEC--GLFTCKSCGRVHPEEQGWICDPCHLARVVKIGSLEWYYEHVKA 127
             +  +V  +R  L+      T ++C R +   +         A V    S   Y++    
Sbjct: 965  SWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRALERTQ---AAVYLQASWRGYWQRKLY 1021

Query: 128  RFKRFGSAKVIRSLHGRLQGGAGPELISEERSGDSDQTD--EDGEPGSEAQAQAQPFGSK 185
            R ++    ++     G LQ  +  ++ISE++  +  + +  E    G+E   Q Q  G +
Sbjct: 1022 RHQKQSIIRLQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQ 1081

Query: 186  KKRLLSVHDFDFEGDSDDSTQPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLE 245
            +              ++   +P     HL+S PE + S +S  + S  EK AP   + L 
Sbjct: 1082 QV-------------AEQGPEPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLP 1128

Query: 246  EADTGASGCHSHPEEQPTS 264
               T A+  H   E+ P+S
Sbjct: 1129 PQKTVAAESH---EKVPSS 1144


>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
          Length = 694

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 67/312 (21%), Positives = 119/312 (38%), Gaps = 41/312 (13%)

Query: 9   KLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCL 68
           +LTDEE + +  V+ R   +   E+ER+  L  ++  E+ ++ +  D  +     C  C 
Sbjct: 49  ELTDEEKEIINRVIARAEKMEEMEQERIGRLVDRL--ENMRKNVAGDGVN----RCILCG 102

Query: 69  QPYQLLVNSKRQCLECGLFTCKSCG-----RVHPEEQGWICDPCHLARVVKIGSLEWYYE 123
           +   +L ++   C +C    C  CG     R+H     W+C  C   R V   S  W+++
Sbjct: 103 EQLGMLGSACVVCEDCKKNVCTKCGVETNNRLH---SVWLCKICIEQREVWKRSGAWFFK 159

Query: 124 HVKAR-------FKRFGSAKVIRSLHGRLQGGAGPEL--------ISEERSGDSDQTDED 168
               +        K+    + +       Q    P+          SE+R G   +T  D
Sbjct: 160 GFPKQVLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPD 219

Query: 169 --GEPGSEAQAQAQPFGSKKKRLLSVHD---FDFEGDSDDSTQPQGHSLHLSSVPEARDS 223
               PG           S+ +   S  D   +D  G + DS++        +SV  +R +
Sbjct: 220 PASAPGRGNYGPPVRRASEARMSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPA 279

Query: 224 PQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSH 283
           P S+   +  +   P    G   +  G       P+++P  ++PS  G  A   PP    
Sbjct: 280 PGSVQSPAPPQPGQPGTPGG---SRPGPGPAGRFPDQKP-EVAPSDPGTTA---PPREER 332

Query: 284 RMALGTAAALGS 295
              +G   A+G+
Sbjct: 333 TGGVGGYPAVGA 344


>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
          Length = 690

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 67/312 (21%), Positives = 119/312 (38%), Gaps = 41/312 (13%)

Query: 9   KLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCL 68
           +LTDEE + +  V+ R   +   E+ER+  L  ++  E+ ++ +  D  +     C  C 
Sbjct: 45  ELTDEEKEIINRVIARAEKMEEMEQERIGRLVDRL--ENMRKNVAGDGVN----RCILCG 98

Query: 69  QPYQLLVNSKRQCLECGLFTCKSCG-----RVHPEEQGWICDPCHLARVVKIGSLEWYYE 123
           +   +L ++   C +C    C  CG     R+H     W+C  C   R V   S  W+++
Sbjct: 99  EQLGMLGSACVVCEDCKKNVCTKCGVETNNRLH---SVWLCKICIEQREVWKRSGAWFFK 155

Query: 124 HVKAR-------FKRFGSAKVIRSLHGRLQGGAGPEL--------ISEERSGDSDQTDED 168
               +        K+    + +       Q    P+          SE+R G   +T  D
Sbjct: 156 GFPKQVLPQPMPIKKTKPQQPVSEPAAPEQPAPEPKHPARAPARGDSEDRRGPGQKTGPD 215

Query: 169 --GEPGSEAQAQAQPFGSKKKRLLSVHD---FDFEGDSDDSTQPQGHSLHLSSVPEARDS 223
               PG           S+ +   S  D   +D  G + DS++        +SV  +R +
Sbjct: 216 PASAPGRGNYGPPVRRASEARMSSSSRDSESWDHSGGAGDSSRSPAGLRRANSVQASRPA 275

Query: 224 PQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSH 283
           P S+   +  +   P    G   +  G       P+++P  ++PS  G  A   PP    
Sbjct: 276 PGSVQSPAPPQPGQPGTPGG---SRPGPGPAGRFPDQKP-EVAPSDPGTTA---PPREER 328

Query: 284 RMALGTAAALGS 295
              +G   A+G+
Sbjct: 329 TGGVGGYPAVGA 340


>gi|244790020 synaptotagmin-like 2 isoform i [Homo sapiens]
          Length = 935

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 120/597 (20%), Positives = 207/597 (34%), Gaps = 78/597 (13%)

Query: 5   LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSD-------TA 57
           +DLS LT+EE + +++V+QRD  L+R EEER+  L  KIK +   + +            
Sbjct: 2   IDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKR 61

Query: 58  HLNETHCA-------RCLQPYQLLVNSKRQ---CLECGLFTCKSCGRVHPEEQGWICDPC 107
           H ++ H A       R  +P      SK +     E  +        + PE  G + +P 
Sbjct: 62  HRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPE 121

Query: 108 HLARVVKIGS---------LEWYYEHV--------KARFKRFGSAKVIRSLHGRLQGGAG 150
             A      S         ++   E+         K R   F S+K+     G       
Sbjct: 122 EDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKQRKNPFNSSKL---PEGHSSQQTK 178

Query: 151 PELISEERSGDSDQTDED-----GEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDST 205
            E     R+G    + ED      E  + A    Q     K+ L  + +    G    + 
Sbjct: 179 NEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSN----GSQIKAP 234

Query: 206 QPQGHSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSI 265
            P+   +   S    +D  QS   +      A     G+ + ++ +S   S       + 
Sbjct: 235 IPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNF 294

Query: 266 SPSRHGALAELCPPGGS-HRMALGTAAALGSNVIRNEQLPLQYLADVDTSDE-------- 316
            P      +++  PG + H        +L  N   N   PL+++      DE        
Sbjct: 295 EPK-----SKIVSPGLTIHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLI 349

Query: 317 ---ESIRAHVMASHHSKRRGRASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAG 373
              E     V+ S   K     + +++ F+ +   S       + ++T  P ++K     
Sbjct: 350 HGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQ 409

Query: 374 VRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQAD----- 428
             T        L    E LT+     E S    E KD+ +E  R +SV P   AD     
Sbjct: 410 PMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHC 469

Query: 429 ----PEVGTAAHQTNRQEKSPQDPGDPVQ-YNRTTDEEL--SELEDRVAVTASEVQQAES 481
               P         +RQ+ S ++P   ++   R+   ++    LED   +++    QA+ 
Sbjct: 470 VEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSAARKMPSKSLED---ISSDSSNQAKV 526

Query: 482 EVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEA 538
           +    E   +A   + +  +P         L      V   L    +D   D +SE+
Sbjct: 527 DNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASES 583


>gi|15011902 synaptotagmin-like 2 isoform a [Homo sapiens]
          Length = 910

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 21/48 (43%), Positives = 33/48 (68%)

Query: 5  LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKREL 52
          +DLS LT+EE + +++V+QRD  L+R EEER+  L  KIK +   + +
Sbjct: 2  IDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNM 49


>gi|244790013 synaptotagmin-like 2 isoform g [Homo sapiens]
          Length = 934

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 21/48 (43%), Positives = 33/48 (68%)

Query: 5  LDLSKLTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKREL 52
          +DLS LT+EE + +++V+QRD  L+R EEER+  L  KIK +   + +
Sbjct: 2  IDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNM 49


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 54/227 (23%), Positives = 76/227 (33%), Gaps = 23/227 (10%)

Query: 133  GSAKVIRSLHGRLQGGAGPELISEERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSV 192
            GS    R      Q G G           S Q D      S     A P  S+ +     
Sbjct: 3481 GSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVS 3540

Query: 193  HDFDFEGDSDDSTQPQGHSL--HLSSVPE-ARDSPQSLTDESCSEKAAPHKAE-----GL 244
             D D +G S+DS +  G +   H  S  E +RD  +  T          H AE     G 
Sbjct: 3541 QDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGT 3600

Query: 245  EEADTGASGCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNE--- 301
              A+  + G  +   EQ  S +  RHG+  +       H    G      S+ +R+    
Sbjct: 3601 HHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHS---GIGHGQASSAVRDSGHR 3657

Query: 302  ----QLPLQYLADVDTSDEESIRAHVMA-----SHHSKRRGRASSES 339
                          + SD +S+ AH  A     SH    RGR++  S
Sbjct: 3658 GSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRS 3704



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 49/205 (23%), Positives = 77/205 (37%), Gaps = 33/205 (16%)

Query: 155 SEERSGDSDQTDEDGEPGSEAQAQAQ--------------PFGSKKKRLLSVHDFDFEGD 200
           +EE+SGD   T   G    EA +QA               P  S+ +      D D +G 
Sbjct: 573 NEEQSGDG--TRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGH 630

Query: 201 SDDSTQPQG---HSLHLSSVPEARDS---PQSLTDESC--SEKAAPHKAEGLEEADTGAS 252
           S+DS +  G    + H S+  ++RD    P+S  ++       A   +  G       +S
Sbjct: 631 SEDSERWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNSSS 690

Query: 253 GCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNE-------QLPL 305
           G  +   EQ  S +  RHG+  +L     S     GT     S+ +R+            
Sbjct: 691 GQAASSHEQARSSAGERHGSRHQLQSADSSRHS--GTGHGQASSAVRDSGHRGSSGSQAT 748

Query: 306 QYLADVDTSDEESIRAHVMASHHSK 330
                 + SD +S+  H  A HH +
Sbjct: 749 DSEGHSEDSDTQSVSGHGQAGHHQQ 773



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 54/222 (24%), Positives = 88/222 (39%), Gaps = 27/222 (12%)

Query: 152 ELISEERSGDSDQTDEDGEPGSE--AQAQAQPFGSKKKRLLSV-HDFDFEGDSDDSTQPQ 208
           ++    RS D   + +      E  +Q   Q   ++K+R   V  D D EG S+DS +  
Sbjct: 255 KIYERSRSSDGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHS 314

Query: 209 GHSL---HLSSVPEARDS---PQSLTDESCSE--KAAPHKAEGLEEADTGASGCHSHPEE 260
           G +    H S+  ++RD    P+S  ++  S    A   +  G   A+T + G  +   E
Sbjct: 315 GSASRNHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHE 374

Query: 261 QPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLAD-----VDTSD 315
           Q  S    RHG+  +       H  A G   A  +   R  +      A       + SD
Sbjct: 375 QARSSPGERHGSGHQQSADSSRH-SATGRGQASSAVSDRGHRGSSGSQASDSEGHSENSD 433

Query: 316 EESIRAHVMA-----SHHSKRRGRAS-----SESQIFELNKH 347
            +S+  H  A     SH    RGR+      S S +++++ H
Sbjct: 434 TQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTH 475



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 56/228 (24%), Positives = 86/228 (37%), Gaps = 36/228 (15%)

Query: 147  GGAGPELIS-----EERSGDSDQTD--EDGEPGSEAQA-------QAQPFGSKKKRLLSV 192
            G +GP   S     EE+SGD  +       EP + A +       Q +  GSK  R    
Sbjct: 1533 GQSGPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGS 1592

Query: 193  ---HDFDFEGDSDDSTQPQGHSLHLSSVPEARD-------SPQSLTDESCSE--KAAPHK 240
                D D EG S+DS + +  S   +    AR+       +P+S  ++  S    A   +
Sbjct: 1593 SVSQDRDSEGHSEDSER-RSESASRNHYGSAREQSRHGSRNPRSHQEDRASHGHSAESSR 1651

Query: 241  AEGLEEADTGASGCHSHPEEQPTSISPSRHGA----LAELCPPGGSHRMALGTAAALGSN 296
              G   A+T + G  +  +EQ  S    RHG+     A+     G+ R    +      N
Sbjct: 1652 QSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQDSSVVGDSGN 1711

Query: 297  VIRNEQLPLQYLADVDTSDEESIRAHVMA-----SHHSKRRGRASSES 339
               +           + SD +S+ AH  A     SH    RG++   S
Sbjct: 1712 RGSSGSQASDSEGHSEESDTQSVSAHGQAGPHQQSHQESTRGQSGERS 1759



 Score = 37.0 bits (84), Expect = 0.052
 Identities = 56/219 (25%), Positives = 80/219 (36%), Gaps = 39/219 (17%)

Query: 155  SEERSGDSDQ----------TDEDGEPGSEAQAQAQPFGSKKKRLLSV---HDFDFEGDS 201
            +EE+SGDS +          T  D    S+A  Q Q  GS++ R        D D EG S
Sbjct: 3167 NEEQSGDSSRHSVSRHHEASTHADISRHSQA-VQGQSEGSRRSRRQGSSVSQDSDSEGHS 3225

Query: 202  DDSTQPQGHSL--HLSSVPEARDSPQSLTDESCSEKAAPH-------KAEGLEEADTGAS 252
            +DS +  G +   H  SV E +    S    S  E  A H       +  G   A+T + 
Sbjct: 3226 EDSERWSGSASRNHRGSVQE-QSRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAETSSG 3284

Query: 253  GCHSHPEEQPTSISPSRHGALAELCPPGGSHRMALGTAAALGSNVIRNEQ-------LPL 305
            G  +   EQ  S    RHG+  +       H    G      S+ +R+ +          
Sbjct: 3285 GQAASSHEQARSSPGERHGSRHQQSADSSRHS---GIPRGQASSAVRDSRHWGSSGSQAS 3341

Query: 306  QYLADVDTSDEESIRAHVMA-----SHHSKRRGRASSES 339
                  + SD +S+  H  A     SH    R R+   S
Sbjct: 3342 DSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRS 3380


>gi|238859655 tetratricopeptide repeat domain 31 [Homo sapiens]
          Length = 519

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 46/194 (23%), Positives = 77/194 (39%), Gaps = 25/194 (12%)

Query: 380 VEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTN 439
           V EE   R  EEL +     +  +E++  K ++ +  + +        +P+  T +   +
Sbjct: 151 VTEEEANRLAEELVAEEERMKQKAEKKRLKKKRQKERKRQERLEQYCGEPKASTTS---D 207

Query: 440 RQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAALRAAGLT 499
             E  P  PG+PVQ       +  E ED + ++++ V  A  +V D    ++A R  GL 
Sbjct: 208 GDESPPSSPGNPVQ------GQCGEEEDSLDLSSTFVSLALRKVGDWP--LSARREKGLN 259

Query: 500 VKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNAD--PSSEAKAMAVPYLLRRKFSNSLKS 557
            +P G+                K+G+  E P  +  P    K  A P LL      S + 
Sbjct: 260 QEPQGR-----------GLALQKMGQEEESPPREERPQQSPKVQASPGLLAAALQQS-QE 307

Query: 558 QGKDDDSFDRKSVY 571
             K   SF +   Y
Sbjct: 308 LAKLGTSFAQNGFY 321


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 43/199 (21%), Positives = 71/199 (35%), Gaps = 7/199 (3%)

Query: 375 RTEADVEEEALRRKLEELTSNVS----DQETSSEEEEAKDEKAEPNRDKSVGPLPQADPE 430
           + EA    EA   + EE  S       ++  S  +EEAK      + +K+  P+ +    
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614

Query: 431 VGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRI 490
              A      + KSP +   P +    T EE    E   +    E +  E   S +++  
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674

Query: 491 AALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKAMAVPYLLRRK 550
            +   A   VK   K   K+  P+     + +  K P    A    +AK+   P     K
Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKS---PVKEEAK 731

Query: 551 FSNSLKSQGKDDDSFDRKS 569
                KS  K++     K+
Sbjct: 732 TPEKAKSPVKEEAKSPEKA 750



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 42/174 (24%), Positives = 68/174 (39%), Gaps = 14/174 (8%)

Query: 373 GVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVG 432
           G   E   EEEA     EE T +   +E +S E+EAK     P ++++  P     PE  
Sbjct: 483 GKEEEGGEEEEA--EGGEEETKSPPAEEAASPEKEAK----SPVKEEAKSPAEAKSPEKE 536

Query: 433 TAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAE------SEVSDI 486
            A  ++  + KSP+    P +    +  E    E   A + +EV+  E       E +  
Sbjct: 537 EA--KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 594

Query: 487 ESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKA 540
            +   +   A   VK   K   ++  P+     +    K PE   +    EAK+
Sbjct: 595 PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS 648



 Score = 33.9 bits (76), Expect = 0.44
 Identities = 42/193 (21%), Positives = 63/193 (32%), Gaps = 12/193 (6%)

Query: 374 VRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGT 433
           V+ EA    EA     EE  S    +     +   K+E   P + KS        PE   
Sbjct: 608 VKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE--K 665

Query: 434 AAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAESEVSDIESRIAAL 493
           A      + KSP+    PV+       E    E   +    E +  E   S ++    + 
Sbjct: 666 AKSPVKAEAKSPEKAKSPVK------AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719

Query: 494 RAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNA----DPSSEAKAMAVPYLLRR 549
             A   VK   K   K+  P+     + +  K PE         P ++  A         
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD 779

Query: 550 KFSNSLKSQGKDD 562
           KF    KS  K++
Sbjct: 780 KFPEKAKSPVKEE 792



 Score = 32.0 bits (71), Expect = 1.7
 Identities = 44/212 (20%), Positives = 82/212 (38%), Gaps = 21/212 (9%)

Query: 374 VRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGP---------- 423
           V+ EA   E+A     EE  S    +    EE +  ++   P ++++  P          
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757

Query: 424 -LPQADPEVGTAAHQTNRQ--EKSPQDPGDPVQYN-RTTDEELSELEDRVAVTASEVQQA 479
            L    PE  T A +  R   +K P+    PV+   ++ ++  S L++       E+ + 
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK 817

Query: 480 ESEVSDIESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNAD-PSSEA 538
           E   S ++      +   + VK   K   +   P        K  K+ E P  + P  + 
Sbjct: 818 EEVKSPVKEE---EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874

Query: 539 KAMAVPYLLRRKFSNSLKSQGKDDDSFDRKSV 570
           +    P + + K S   K + K +++ D+K V
Sbjct: 875 EEKKEPAVEKPKES---KVEAKKEEAEDKKKV 903



 Score = 30.8 bits (68), Expect = 3.7
 Identities = 34/173 (19%), Positives = 69/173 (39%), Gaps = 20/173 (11%)

Query: 375  RTEADVEEEALRRKLEE----LTSNVSDQETSSEEEEAKDEKAEPNRDK----SVGPLPQ 426
            + E   ++EA + K+EE          + +  +++EEA+D+K  P  +K     V     
Sbjct: 860  KKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED 919

Query: 427  ADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEELSELEDRVAVTASEVQQAESEVSDI 486
            A P+  T   +    +   ++P  P +      E+    E++ A    E  + E++  + 
Sbjct: 920  AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEK-AKKPEEKPKTEAKAKED 978

Query: 487  ESRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAK 539
            +  ++   +     KP  +   KS+          K  K PE    D +++ K
Sbjct: 979  DKTLSKEPS-----KPKAEKAEKSS------STDQKDSKPPEKATEDKAAKGK 1020



 Score = 29.6 bits (65), Expect = 8.3
 Identities = 38/175 (21%), Positives = 67/175 (38%), Gaps = 22/175 (12%)

Query: 389 LEELT--SNVSDQETSSEEEEAK-----------DEKAEPNRDKSVGPLPQ--ADPEVGT 433
           +EE T  + V+++ T  EE+EAK           +E+AE   +++  P  +  A PE   
Sbjct: 457 VEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPE-KE 515

Query: 434 AAHQTNRQEKSPQDPGDPVQYNRTTDEELSELE------DRVAVTASEVQQAESEVSDIE 487
           A      + KSP +   P +    +  E+   E         A +  E +  E E +   
Sbjct: 516 AKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSP 575

Query: 488 SRIAALRAAGLTVKPSGKPRRKSNLPIFLPRVAGKLGKRPEDPNADPSSEAKAMA 542
           + + +   A    K   K   ++  P        +  K P +  +    EAK+ A
Sbjct: 576 AEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPA 630


>gi|48255931 hepatoma-derived growth factor-related protein 2
           isoform 1 [Homo sapiens]
          Length = 671

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 72/325 (22%), Positives = 123/325 (37%), Gaps = 41/325 (12%)

Query: 155 SEERSGDSDQT-DEDGEPGSEAQAQAQ---PFGS-KKKRLLSVHDFDFEGDSDDSTQPQG 209
           + E S +S++T D+D  P  +A  +A    P G  KKK+  S  D D + DS D  +P+ 
Sbjct: 189 NSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS-DGAKPEP 247

Query: 210 HSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSR 269
            ++  S+   +  S  S +D   S K  P   +  E+      G    PE  P+S S   
Sbjct: 248 VAMARSA--SSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDS 305

Query: 270 HGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHS 329
                E+       R        L +   R ++  L+ L + +  ++E  R    A    
Sbjct: 306 DS--DEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKE--RRRERADRGE 361

Query: 330 KRRGRASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAGVRTEADVEEEALRRKL 389
             RG   S     EL +            +  V     KG G G  + +D E EA   +L
Sbjct: 362 AERGSGGSSGD--ELRED-----------DEPVKKRGRKGRGRGPPSSSDSEPEA---EL 405

Query: 390 EELTSNVSDQETSSEEEEA-----KDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKS 444
           E      + +  SS  E A     K+++  P   +   P+        +     +R+ + 
Sbjct: 406 EREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEK 465

Query: 445 PQDPGDPVQYNRTTDEELSELEDRV 469
            ++P        + +E+L +L   +
Sbjct: 466 KKEP--------SVEEKLQKLHSEI 482



 Score = 30.4 bits (67), Expect = 4.9
 Identities = 16/53 (30%), Positives = 29/53 (54%)

Query: 371 GAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGP 423
           G  +  E   +E+A  +   +L++ V+ + TS + E A+D++ E  RD   GP
Sbjct: 577 GEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGP 629


>gi|14249158 hepatoma-derived growth factor-related protein 2
           isoform 2 [Homo sapiens]
          Length = 670

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 72/325 (22%), Positives = 123/325 (37%), Gaps = 41/325 (12%)

Query: 155 SEERSGDSDQT-DEDGEPGSEAQAQAQ---PFGS-KKKRLLSVHDFDFEGDSDDSTQPQG 209
           + E S +S++T D+D  P  +A  +A    P G  KKK+  S  D D + DS D  +P+ 
Sbjct: 189 NSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS-DGAKPEP 247

Query: 210 HSLHLSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSR 269
            ++  S+   +  S  S +D   S K  P   +  E+      G    PE  P+S S   
Sbjct: 248 VAMARSA--SSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDS 305

Query: 270 HGALAELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHS 329
                E+       R        L +   R ++  L+ L + +  ++E  R    A    
Sbjct: 306 DS--DEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKE--RRRERADRGE 361

Query: 330 KRRGRASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAGVRTEADVEEEALRRKL 389
             RG   S     EL +            +  V     KG G G  + +D E EA   +L
Sbjct: 362 AERGSGGSSGD--ELRED-----------DEPVKKRGRKGRGRGPPSSSDSEPEA---EL 405

Query: 390 EELTSNVSDQETSSEEEEA-----KDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKS 444
           E      + +  SS  E A     K+++  P   +   P+        +     +R+ + 
Sbjct: 406 EREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEK 465

Query: 445 PQDPGDPVQYNRTTDEELSELEDRV 469
            ++P        + +E+L +L   +
Sbjct: 466 KKEP--------SVEEKLQKLHSEI 482



 Score = 30.4 bits (67), Expect = 4.9
 Identities = 16/53 (30%), Positives = 29/53 (54%)

Query: 371 GAGVRTEADVEEEALRRKLEELTSNVSDQETSSEEEEAKDEKAEPNRDKSVGP 423
           G  +  E   +E+A  +   +L++ V+ + TS + E A+D++ E  RD   GP
Sbjct: 577 GEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGP 629


>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
           precursor [Homo sapiens]
          Length = 513

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 96/387 (24%), Positives = 139/387 (35%), Gaps = 88/387 (22%)

Query: 156 EERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLS 215
           E+ SGD    D+D  PG + + +         RL S      + DSDD+ Q    S    
Sbjct: 106 EDDSGDDTFGDDDSGPGPKDRQEGG-----NSRLGS------DEDSDDTIQASEES---- 150

Query: 216 SVPEARDSPQSLTDESC---SEKAAPHKAEGLEEADTGASGCHSHPEEQPT---SISPSR 269
             P+ +DS Q  T ES    +E     K EG      G S   S  EE      S   S 
Sbjct: 151 -APQGQDSAQDTTSESRELDNEDRVDSKPEG------GDSTQESESEEHWVGGGSDGESS 203

Query: 270 HGALAELCPPG------GSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHV 323
           HG  +EL   G       S R   G +    + +   E       A+   S    +  H 
Sbjct: 204 HGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEH- 262

Query: 324 MASHHSKRRGRASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAGVR-TEADVEE 382
             S    R+ R S E    EL+ + +  E      EN+       GL    R ++ D +E
Sbjct: 263 -PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENS--NSRDTGLSQPRRDSKGDSQE 319

Query: 383 EALRRKLEELTSNV-------------SDQETSSE-EEEAKDEKAEPNRD---------- 418
           ++     +E + NV             S QE SSE +EE   E    N D          
Sbjct: 320 DSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQE 379

Query: 419 ----------------KSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEEL 462
                           KS     QAD E   ++   N  E+SP+ P D    N ++ E  
Sbjct: 380 DSDSSEEDSSHTLSHSKSESREEQADSE---SSESLNFSEESPESPEDE---NSSSQE-- 431

Query: 463 SELEDRVAVTASEVQQAESEVSDIESR 489
             L+   +   S+ +++ SE  D +S+
Sbjct: 432 -GLQSHSSSAESQSEESHSEEDDSDSQ 457


>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
           precursor [Homo sapiens]
          Length = 497

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 96/387 (24%), Positives = 139/387 (35%), Gaps = 88/387 (22%)

Query: 156 EERSGDSDQTDEDGEPGSEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLHLS 215
           E+ SGD    D+D  PG + + +         RL S      + DSDD+ Q    S    
Sbjct: 90  EDDSGDDTFGDDDSGPGPKDRQEGG-----NSRLGS------DEDSDDTIQASEES---- 134

Query: 216 SVPEARDSPQSLTDESC---SEKAAPHKAEGLEEADTGASGCHSHPEEQPT---SISPSR 269
             P+ +DS Q  T ES    +E     K EG      G S   S  EE      S   S 
Sbjct: 135 -APQGQDSAQDTTSESRELDNEDRVDSKPEG------GDSTQESESEEHWVGGGSDGESS 187

Query: 270 HGALAELCPPG------GSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHV 323
           HG  +EL   G       S R   G +    + +   E       A+   S    +  H 
Sbjct: 188 HGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEH- 246

Query: 324 MASHHSKRRGRASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAGVR-TEADVEE 382
             S    R+ R S E    EL+ + +  E      EN+       GL    R ++ D +E
Sbjct: 247 -PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENS--NSRDTGLSQPRRDSKGDSQE 303

Query: 383 EALRRKLEELTSNV-------------SDQETSSE-EEEAKDEKAEPNRD---------- 418
           ++     +E + NV             S QE SSE +EE   E    N D          
Sbjct: 304 DSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQE 363

Query: 419 ----------------KSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQYNRTTDEEL 462
                           KS     QAD E   ++   N  E+SP+ P D    N ++ E  
Sbjct: 364 DSDSSEEDSSHTLSHSKSESREEQADSE---SSESLNFSEESPESPEDE---NSSSQE-- 415

Query: 463 SELEDRVAVTASEVQQAESEVSDIESR 489
             L+   +   S+ +++ SE  D +S+
Sbjct: 416 -GLQSHSSSAESQSEESHSEEDDSDSQ 441


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
           [Homo sapiens]
          Length = 1451

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 78/353 (22%), Positives = 132/353 (37%), Gaps = 52/353 (14%)

Query: 155 SEERSGDSDQTDEDGEPG-SEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLH 213
           SE+ S  SD+TD +G+P    AQ +A    +K+           +   D + Q +G +L 
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK-VGDVTPQVKGGAL- 257

Query: 214 LSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGAL 273
               P A+ + +   +   SE       EG E  +   +G  S  +     +      A 
Sbjct: 258 ----PPAKRAKKPEEESESSE-------EGSESEEEAPAGTRSQVKASEKILQVRAASAP 306

Query: 274 AELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRG 333
           A+  P  G+     G A A+ S     +       +  ++SD E       A   +K  G
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366

Query: 334 RASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAGVRTEADVEEEALRRKLEELT 393
           + S            ++     +  +     P  K   A  + +A   EE          
Sbjct: 367 KTSQVG--------AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE---------- 408

Query: 394 SNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQ 453
               D ++SSEE ++++E   P + K  G  PQ        A ++ R+  +P  P     
Sbjct: 409 ----DSQSSSEESDSEEE--APAQAKPSGKAPQV-RAASAPAKESPRKGAAPAPP----- 456

Query: 454 YNRTTDEELSELEDRVAVTASEVQQAESEVSDIE-SRIAALRAAGLTVKPSGK 505
             R T    ++++        E  ++ SE SD +   +AA+ AA   VKP GK
Sbjct: 457 --RKTGPAAAQVQ---VGKQEEDSRSSSEESDSDREALAAMNAA--QVKPLGK 502


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
           [Homo sapiens]
          Length = 1488

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 78/353 (22%), Positives = 132/353 (37%), Gaps = 52/353 (14%)

Query: 155 SEERSGDSDQTDEDGEPG-SEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLH 213
           SE+ S  SD+TD +G+P    AQ +A    +K+           +   D + Q +G +L 
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK-VGDVTPQVKGGAL- 257

Query: 214 LSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGAL 273
               P A+ + +   +   SE       EG E  +   +G  S  +     +      A 
Sbjct: 258 ----PPAKRAKKPEEESESSE-------EGSESEEEAPAGTRSQVKASEKILQVRAASAP 306

Query: 274 AELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRG 333
           A+  P  G+     G A A+ S     +       +  ++SD E       A   +K  G
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366

Query: 334 RASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAGVRTEADVEEEALRRKLEELT 393
           + S            ++     +  +     P  K   A  + +A   EE          
Sbjct: 367 KTSQVG--------AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE---------- 408

Query: 394 SNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQ 453
               D ++SSEE ++++E   P + K  G  PQ        A ++ R+  +P  P     
Sbjct: 409 ----DSQSSSEESDSEEE--APAQAKPSGKAPQV-RAASAPAKESPRKGAAPAPP----- 456

Query: 454 YNRTTDEELSELEDRVAVTASEVQQAESEVSDIE-SRIAALRAAGLTVKPSGK 505
             R T    ++++        E  ++ SE SD +   +AA+ AA   VKP GK
Sbjct: 457 --RKTGPAAAQVQ---VGKQEEDSRSSSEESDSDREALAAMNAA--QVKPLGK 502


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
           [Homo sapiens]
          Length = 1450

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 78/353 (22%), Positives = 132/353 (37%), Gaps = 52/353 (14%)

Query: 155 SEERSGDSDQTDEDGEPG-SEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLH 213
           SE+ S  SD+TD +G+P    AQ +A    +K+           +   D + Q +G +L 
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK-VGDVTPQVKGGAL- 257

Query: 214 LSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGAL 273
               P A+ + +   +   SE       EG E  +   +G  S  +     +      A 
Sbjct: 258 ----PPAKRAKKPEEESESSE-------EGSESEEEAPAGTRSQVKASEKILQVRAASAP 306

Query: 274 AELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRG 333
           A+  P  G+     G A A+ S     +       +  ++SD E       A   +K  G
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366

Query: 334 RASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAGVRTEADVEEEALRRKLEELT 393
           + S            ++     +  +     P  K   A  + +A   EE          
Sbjct: 367 KTSQVG--------AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE---------- 408

Query: 394 SNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQ 453
               D ++SSEE ++++E   P + K  G  PQ        A ++ R+  +P  P     
Sbjct: 409 ----DSQSSSEESDSEEE--APAQAKPSGKAPQV-RAASAPAKESPRKGAAPAPP----- 456

Query: 454 YNRTTDEELSELEDRVAVTASEVQQAESEVSDIE-SRIAALRAAGLTVKPSGK 505
             R T    ++++        E  ++ SE SD +   +AA+ AA   VKP GK
Sbjct: 457 --RKTGPAAAQVQ---VGKQEEDSRSSSEESDSDREALAAMNAA--QVKPLGK 502


>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
           [Homo sapiens]
          Length = 958

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 78/353 (22%), Positives = 132/353 (37%), Gaps = 52/353 (14%)

Query: 155 SEERSGDSDQTDEDGEPG-SEAQAQAQPFGSKKKRLLSVHDFDFEGDSDDSTQPQGHSLH 213
           SE+ S  SD+TD +G+P    AQ +A    +K+           +   D + Q +G +L 
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK-VGDVTPQVKGGAL- 257

Query: 214 LSSVPEARDSPQSLTDESCSEKAAPHKAEGLEEADTGASGCHSHPEEQPTSISPSRHGAL 273
               P A+ + +   +   SE       EG E  +   +G  S  +     +      A 
Sbjct: 258 ----PPAKRAKKPEEESESSE-------EGSESEEEAPAGTRSQVKASEKILQVRAASAP 306

Query: 274 AELCPPGGSHRMALGTAAALGSNVIRNEQLPLQYLADVDTSDEESIRAHVMASHHSKRRG 333
           A+  P  G+     G A A+ S     +       +  ++SD E       A   +K  G
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366

Query: 334 RASSESQIFELNKHISAVECLLTYLENTVVPPLAKGLGAGVRTEADVEEEALRRKLEELT 393
           + S            ++     +  +     P  K   A  + +A   EE          
Sbjct: 367 KTSQVG--------AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE---------- 408

Query: 394 SNVSDQETSSEEEEAKDEKAEPNRDKSVGPLPQADPEVGTAAHQTNRQEKSPQDPGDPVQ 453
               D ++SSEE ++++E   P + K  G  PQ        A ++ R+  +P  P     
Sbjct: 409 ----DSQSSSEESDSEEE--APAQAKPSGKAPQV-RAASAPAKESPRKGAAPAPP----- 456

Query: 454 YNRTTDEELSELEDRVAVTASEVQQAESEVSDIE-SRIAALRAAGLTVKPSGK 505
             R T    ++++        E  ++ SE SD +   +AA+ AA   VKP GK
Sbjct: 457 --RKTGPAAAQVQ---VGKQEEDSRSSSEESDSDREALAAMNAA--QVKPLGK 502


>gi|194328736 PHD finger protein 10 isoform b [Homo sapiens]
          Length = 496

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 25/73 (34%), Positives = 33/73 (45%), Gaps = 6/73 (8%)

Query: 39  LKGKIKKESSKRELLSDTAHLNETHCARCLQPYQLLVNSKR----QCLECGLFTCKSCGR 94
           LKGK   +  K E L   +    +    CL     LV+  +    QC+EC   TC  CG+
Sbjct: 382 LKGKESNKKGKAESLIHCSQCENSGHPSCLDMTMELVSMIKTYPWQCMECK--TCIICGQ 439

Query: 95  VHPEEQGWICDPC 107
            H EE+   CD C
Sbjct: 440 PHHEEEMMFCDMC 452


>gi|194328734 PHD finger protein 10 isoform a [Homo sapiens]
          Length = 498

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 25/73 (34%), Positives = 33/73 (45%), Gaps = 6/73 (8%)

Query: 39  LKGKIKKESSKRELLSDTAHLNETHCARCLQPYQLLVNSKR----QCLECGLFTCKSCGR 94
           LKGK   +  K E L   +    +    CL     LV+  +    QC+EC   TC  CG+
Sbjct: 384 LKGKESNKKGKAESLIHCSQCENSGHPSCLDMTMELVSMIKTYPWQCMECK--TCIICGQ 441

Query: 95  VHPEEQGWICDPC 107
            H EE+   CD C
Sbjct: 442 PHHEEEMMFCDMC 454


>gi|5902064 rabphilin 3A-like (without C2 domains) [Homo sapiens]
          Length = 315

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 30/117 (25%), Positives = 54/117 (46%), Gaps = 9/117 (7%)

Query: 10  LTDEEAQHVLEVVQRDFDLRRKEEERLEALKGKIKKESSKRELLSDTAHLNETHCARCLQ 69
           L+  E + +L+V+QR   L   E++R+  L  ++  E+ +R ++ +      + C  C +
Sbjct: 47  LSPAEVEAILQVIQRAERLDVLEQQRIGRLVERL--ETMRRNVMGNGL----SQCLLCGE 100

Query: 70  PYQLLVNSKRQCLECGLFTCKSCG-RVHPEEQG--WICDPCHLARVVKIGSLEWYYE 123
               L +S   C +C    C  CG    P ++   W+C  C   R V   S  W+Y+
Sbjct: 101 VLGFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYK 157


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,900,486
Number of Sequences: 37866
Number of extensions: 1267597
Number of successful extensions: 8961
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 385
Number of HSP's that attempted gapping in prelim test: 7592
Number of HSP's gapped (non-prelim): 1605
length of query: 600
length of database: 18,247,518
effective HSP length: 108
effective length of query: 492
effective length of database: 14,157,990
effective search space: 6965731080
effective search space used: 6965731080
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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