Search of human proteins with 108796058

Search of human proteins with 108796058

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|108796058 ral guanine nucleotide dissociation stimulator
isoform 2 [Homo sapiens]
         (859 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|108796058 ral guanine nucleotide dissociation stimulator isof...  1714   0.0  
gi|24307909 ral guanine nucleotide dissociation stimulator isofo...  1702   0.0  
gi|93102367 ral guanine nucleotide dissociation stimulator-like ...   522   e-148
gi|239582763 ral guanine nucleotide dissociation stimulator-like...   381   e-105
gi|239582765 ral guanine nucleotide dissociation stimulator-like...   379   e-105
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2...   377   e-104
gi|23957680 ral guanine nucleotide dissociation stimulator-like ...   329   6e-90
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ...   119   1e-26
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa...   107   4e-23
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...   105   1e-22
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...   105   1e-22
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa...   105   1e-22
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo...   100   4e-21
gi|154689780 son of sevenless homolog 2 [Homo sapiens]                 88   4e-17
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom...    86   1e-16
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom...    86   1e-16
gi|15529996 son of sevenless homolog 1 [Homo sapiens]                  84   4e-16
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]              82   3e-15
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]             82   3e-15
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]             82   3e-15
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                 77   9e-14
gi|33186895 selenoprotein V [Homo sapiens]                             75   3e-13
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa...    75   3e-13
gi|169790903 cyclin-dependent kinase inhibitor 1C isoform b [Hom...    74   8e-13
gi|169790899 cyclin-dependent kinase inhibitor 1C isoform b [Hom...    74   8e-13
gi|4557441 cyclin-dependent kinase inhibitor 1C isoform a [Homo ...    74   8e-13
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]     74   8e-13
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg...    68   3e-11
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu...    68   3e-11
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul...    67   7e-11

>gi|108796058 ral guanine nucleotide dissociation stimulator isoform
           2 [Homo sapiens]
          Length = 859

 Score = 1714 bits (4440), Expect = 0.0
 Identities = 859/859 (100%), Positives = 859/859 (100%)

Query: 1   MMVDCQSSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRT 60
           MMVDCQSSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRT
Sbjct: 1   MMVDCQSSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRT 60

Query: 61  VKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSR 120
           VKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSR
Sbjct: 61  VKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSR 120

Query: 121 YGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGS 180
           YGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGS
Sbjct: 121 YGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGS 180

Query: 181 DLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEP 240
           DLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEP
Sbjct: 181 DLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEP 240

Query: 241 APTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAP 300
           APTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAP
Sbjct: 241 APTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAP 300

Query: 301 APVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIW 360
           APVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIW
Sbjct: 301 APVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIW 360

Query: 361 SQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRI 420
           SQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRI
Sbjct: 361 SQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRI 420

Query: 421 LKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKE 480
           LKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKE
Sbjct: 421 LKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKE 480

Query: 481 GTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKR 540
           GTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKR
Sbjct: 481 GTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKR 540

Query: 541 RKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNT 600
           RKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNT
Sbjct: 541 RKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNT 600

Query: 601 LRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSS 660
           LRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSS
Sbjct: 601 LRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSS 660

Query: 661 SSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTH 720
           SSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTH
Sbjct: 661 SSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTH 720

Query: 721 KRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDK 780
           KRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDK
Sbjct: 721 KRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDK 780

Query: 781 HNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGA 840
           HNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGA
Sbjct: 781 HNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGA 840

Query: 841 SSTLPRMKQKGLKIAKGIF 859
           SSTLPRMKQKGLKIAKGIF
Sbjct: 841 SSTLPRMKQKGLKIAKGIF 859


>gi|24307909 ral guanine nucleotide dissociation stimulator isoform
           1 [Homo sapiens]
          Length = 914

 Score = 1702 bits (4408), Expect = 0.0
 Identities = 853/854 (99%), Positives = 854/854 (100%)

Query: 6   QSSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGT 65
           +SSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGT
Sbjct: 61  ESSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGT 120

Query: 66  LEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCIL 125
           LEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCIL
Sbjct: 121 LEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCIL 180

Query: 126 PYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERR 185
           PYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERR
Sbjct: 181 PYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERR 240

Query: 186 AHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPA 245
           AHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPA
Sbjct: 241 AHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPA 300

Query: 246 PGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPS 305
           PGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPS
Sbjct: 301 PGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPS 360

Query: 306 LQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDK 365
           LQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDK
Sbjct: 361 LQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDK 420

Query: 366 KGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFS 425
           KGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFS
Sbjct: 421 KGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFS 480

Query: 426 SLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKF 485
           SLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKF
Sbjct: 481 SLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKF 540

Query: 486 ATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFE 545
           ATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFE
Sbjct: 541 ATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFE 600

Query: 546 VIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKK 605
           VIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKK
Sbjct: 601 VIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKK 660

Query: 606 NTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVE 665
           NTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVE
Sbjct: 661 NTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVE 720

Query: 666 EINISFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVS 725
           EINISFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVS
Sbjct: 721 EINISFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVS 780

Query: 726 GLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEE 785
           GLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEE
Sbjct: 781 GLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEE 840

Query: 786 EEPEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLP 845
           EEPEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLP
Sbjct: 841 EEPEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLP 900

Query: 846 RMKQKGLKIAKGIF 859
           RMKQKGLKIAKGIF
Sbjct: 901 RMKQKGLKIAKGIF 914


>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
           [Homo sapiens]
          Length = 803

 Score =  522 bits (1345), Expect = e-148
 Identities = 282/545 (51%), Positives = 389/545 (71%), Gaps = 27/545 (4%)

Query: 323 EKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQF 382
           E      F  DLVAEQ T MDA+LFKKVVP+HCLG IWS+RDKK  +HLAPTIRAT++QF
Sbjct: 259 ESAEFTCFSEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQF 318

Query: 383 NSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRL 442
           N++  CV++T LG +  K   RA+++E WI +A ECR+LKNFSSL AI+SALQSNSI+RL
Sbjct: 319 NTLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRL 378

Query: 443 KKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKR---- 498
           KKTW  V RD   +F++LS+IFSD NN+  SRELL+KEGTSKFA L+ + K  QKR    
Sbjct: 379 KKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRR 438

Query: 499 ---PKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQS 555
               K+ G++QGTVPYLGTFLTDL MLDTA++DY+ G LINFEKRR+EFEVIAQIKLLQS
Sbjct: 439 LQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQS 498

Query: 556 ACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSD 615
           ACN+Y + PD++F  WF+  + L+E ESY LSCE+E  +++++ + + +K  ++VKR S 
Sbjct: 499 ACNSYCMTPDQKFIQWFQRQQLLTEEESYALSCEIEAAADASTTSPKPRK--SMVKRLSL 556

Query: 616 RQAPSTELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPES 675
               S  +    +S + + +Q +     SSG+  D++SV S  S+ S+ EE +I+ + ++
Sbjct: 557 LFLGSDMI----TSPTPTKEQPKSTASGSSGESMDSVSVSSCESNHSEAEEGSITPM-DT 611

Query: 676 PDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVAA-------TRTHKRSVSGLC 728
           PD  +KK     S+SS   S I S  +++S  S+   P+++        + HKRSVS   
Sbjct: 612 PDEPQKKL----SESSSSCSSIHSMDTNSSGMSSLINPLSSPPSCNNNPKIHKRSVSVTS 667

Query: 729 NSSSAL-PLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEE 787
            +S+ L P+YNQQ  D CIIR+S++ +NGNMYKSI++TSQDK PAVI++AM KHNL+ + 
Sbjct: 668 ITSTVLPPVYNQQNEDTCIIRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDP 727

Query: 788 PEDYELLQILSDDRKLKIPENANVFYAMNSTANYDFVL-KKRTFTKGVKVKHGASSTLPR 846
            E+YEL+Q++S+D++L IP++ANVFYAMNS  N+DF+L KK +  + VK++   S TLPR
Sbjct: 728 AEEYELVQVISEDKELVIPDSANVFYAMNSQVNFDFILRKKNSMEEQVKLRSRTSLTLPR 787

Query: 847 MKQKG 851
             ++G
Sbjct: 788 TAKRG 792



 Score =  182 bits (461), Expect = 2e-45
 Identities = 94/202 (46%), Positives = 130/202 (64%), Gaps = 21/202 (10%)

Query: 6   QSSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENES-----ALNLYETCKVRT 60
           +SS Q+ GEE+  G +Y ++L++VQ+    NKG RWLG E +       ++ YETCK+RT
Sbjct: 44  ESSIQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQYETCKIRT 103

Query: 61  VKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSR 120
           +KAGTLEKLVE+L+ AF  +D +Y++IFL TYR F +T++VL+LL  RYG   +      
Sbjct: 104 IKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTS------ 157

Query: 121 YGCILPYSDEDGGPQDQ-----LKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQL 175
                P  +EDG          ++NAI+SIL  WLDQ +EDF +PP FPCL++L+ Y+  
Sbjct: 158 -----PNCEEDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTR 212

Query: 176 NMPGSDLERRAHLLLAQLEHSE 197
            MPGSD ERRA  LL Q +  E
Sbjct: 213 MMPGSDPERRAQNLLEQFQKQE 234


>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
           isoform 2 [Homo sapiens]
          Length = 710

 Score =  381 bits (978), Expect = e-105
 Identities = 232/553 (41%), Positives = 315/553 (56%), Gaps = 49/553 (8%)

Query: 281 EPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFT 340
           E   EQ+  P Q     P  A       S  +    E GL  + P LL F  D VAEQ T
Sbjct: 198 EAEREQEEEPPQVWTGPPRVAQTSDPDSS-EACAEEEEGLMPQGPQLLDFSVDEVAEQLT 256

Query: 341 LMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTK 400
           L+D ELF KV  Y CLGS+WSQRD+ G    +PT+RATV QFN+V  CV+ + LG     
Sbjct: 257 LIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLA 316

Query: 401 APDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKL 460
           AP RA+ +E WI +A+ CR L+NFSSL AILSALQSN I+RLK++W  VSR+    F+KL
Sbjct: 317 APQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKL 376

Query: 461 SEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQGTVPYLGTFLTDL 519
           S+IFSDENN+  SRE+L +E  ++ +  E N P     +P       G VPYLGTFLTDL
Sbjct: 377 SQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----GPVPYLGTFLTDL 431

Query: 520 VMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLS 579
           VMLDTA+ D L G LINFEKRRKE+E++A+I+ LQ  C +Y+++P     A   A  +L+
Sbjct: 432 VMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLT 491

Query: 580 ETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRC 639
           E +SY LS  +EPP+ S  ++ R ++  ++ KR S + A     S SGS           
Sbjct: 492 EEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSP---------- 541

Query: 640 GPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISS 699
                             G  SS    ++    P SP  ++     + + S P + G   
Sbjct: 542 ------------------GDPSSPTSSVSPGSPPSSPRSRD-----APAGSPPASPGPQG 578

Query: 700 ASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMY 759
            S+    S    +P             L   S  +PL  QQ  +  +IRVS+D D+GN+Y
Sbjct: 579 PSTKLPLSLDLPSP---------RPFALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLY 629

Query: 760 KSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTA 819
           +SIL+TSQDKAP+V+R+A+ KHN+ +    DY+L Q+L  DR L IP+NANVFYAM+  A
Sbjct: 630 RSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVA 689

Query: 820 NYDFVLKKRTFTK 832
             DF+L+++  T+
Sbjct: 690 PRDFMLRRKEGTR 702



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 60/218 (27%), Positives = 98/218 (44%), Gaps = 20/218 (9%)

Query: 10  QEIGEELINGVIYSISLRKVQLHH-------GGNKGQRWLGYENESALNLYETCKVRTVK 62
           Q+ GEE  +G +YS+SLR+ +          GG++    +     +    Y T KVR ++
Sbjct: 15  QDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIA----NTFLHYRTSKVRVLR 70

Query: 63  AGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYG 122
           A  LE+LV  LV   +  D S++  FL TYR F  T  +L  L         +      G
Sbjct: 71  AARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLL------PPMPPPPPPG 124

Query: 123 CILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDL 182
             +  +       ++   A+ S+LG+WL  + +DF  PP    L  +  ++    PGS  
Sbjct: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184

Query: 183 ERRAHLLLAQ-LEHSEPIEAE--PEALSPVPALKPTPE 217
            ++A  LL   LE +E  + E  P+  +  P +  T +
Sbjct: 185 AQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSD 222


>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
           isoform 1 [Homo sapiens]
          Length = 716

 Score =  379 bits (974), Expect = e-105
 Identities = 239/553 (43%), Positives = 318/553 (57%), Gaps = 43/553 (7%)

Query: 281 EPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFT 340
           E   EQ+  P Q     P  A       S  +    E GL  + P LL F  D VAEQ T
Sbjct: 198 EAEREQEEEPPQVWTGPPRVAQTSDPDSS-EACAEEEEGLMPQGPQLLDFSVDEVAEQLT 256

Query: 341 LMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTK 400
           L+D ELF KV  Y CLGS+WSQRD+ G    +PT+RATV QFN+V  CV+ + LG     
Sbjct: 257 LIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGAPGLA 316

Query: 401 APDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKL 460
           AP RA+ +E WI +A+ CR L+NFSSL AILSALQSN I+RLK++W  VSR+    F+KL
Sbjct: 317 APQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKL 376

Query: 461 SEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQGTVPYLGTFLTDL 519
           S+IFSDENN+  SRE+L +E  ++ +  E N P     +P       G VPYLGTFLTDL
Sbjct: 377 SQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----GPVPYLGTFLTDL 431

Query: 520 VMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLS 579
           VMLDTA+ D L G LINFEKRRKE+E++A+I+ LQ  C +Y+++P     A   A  +L+
Sbjct: 432 VMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLT 491

Query: 580 ETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQLRC 639
           E +SY LS  +EPP+ S  ++ R ++  ++ KR S + A     S SGS    S      
Sbjct: 492 EEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSSPT--- 548

Query: 640 GPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISS 699
               SS  I+ ++S  S  SS            P S D         +  +SP   G  S
Sbjct: 549 ----SSLCISPSVSPGSPPSS------------PRSRDAPA-----GSPPASPGPQG-PS 586

Query: 700 ASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDVDNGNMY 759
                S    S  P A           L   S  +PL  QQ  +  +IRVS+D D+GN+Y
Sbjct: 587 TKLPLSLDLPSPRPFA-----------LPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLY 635

Query: 760 KSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNSTA 819
           +SIL+TSQDKAP+V+R+A+ KHN+ +    DY+L Q+L  DR L IP+NANVFYAM+  A
Sbjct: 636 RSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVA 695

Query: 820 NYDFVLKKRTFTK 832
             DF+L+++  T+
Sbjct: 696 PRDFMLRRKEGTR 708



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 60/218 (27%), Positives = 98/218 (44%), Gaps = 20/218 (9%)

Query: 10  QEIGEELINGVIYSISLRKVQLHH-------GGNKGQRWLGYENESALNLYETCKVRTVK 62
           Q+ GEE  +G +YS+SLR+ +          GG++    +     +    Y T KVR ++
Sbjct: 15  QDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIA----NTFLHYRTSKVRVLR 70

Query: 63  AGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYG 122
           A  LE+LV  LV   +  D S++  FL TYR F  T  +L  L         +      G
Sbjct: 71  AARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLL------PPMPPPPPPG 124

Query: 123 CILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDL 182
             +  +       ++   A+ S+LG+WL  + +DF  PP    L  +  ++    PGS  
Sbjct: 125 VEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPAHSDLGSVRTFLGWAAPGSAE 184

Query: 183 ERRAHLLLAQ-LEHSEPIEAE--PEALSPVPALKPTPE 217
            ++A  LL   LE +E  + E  P+  +  P +  T +
Sbjct: 185 AQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSD 222


>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
           [Homo sapiens]
          Length = 777

 Score =  377 bits (969), Expect = e-104
 Identities = 233/594 (39%), Positives = 331/594 (55%), Gaps = 78/594 (13%)

Query: 308 PSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKG 367
           P  P P+        +   +LVF  D +AEQ TL+DAELF  ++P  CLG +W  RD+ G
Sbjct: 220 PDLPKPLALPGDPPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPG 279

Query: 368 KEHLAPTIRATVTQFNSVANCVITTCLGNRST------------KAPDRARVVEHWIEVA 415
             HL P++RATVTQFN VA  V+++ LG  ST            + P RAR++E WI VA
Sbjct: 280 HSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVA 339

Query: 416 RECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRE 475
            ECR+L+NFSS+YA++SALQS+ IHRL+  W + +RDS R+F  L +IFS+E+NYS SRE
Sbjct: 340 EECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRE 399

Query: 476 LLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLI 535
           LL++E   + + LE + K+A +     G   G VPYLGTFL DLVMLD A KD L    I
Sbjct: 400 LLVQEVKLQ-SPLEPHSKKAPRSGSRGG---GVVPYLGTFLKDLVMLDAASKDELENGYI 455

Query: 536 NFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSE 595
           NF+KRRKEF V+++++ LQ+ C  Y++ PD     W + +  L+E +S+ +SCE+EPP  
Sbjct: 456 NFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCEVEPPGS 515

Query: 596 SASNTLRTKKNTAIVKRWSD-------------RQAPST---ELSTSGSSHSKSCDQLRC 639
           S     R  + T ++ +W++                PST   E  T+ +       Q   
Sbjct: 516 SDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLLTRLAQHMK 575

Query: 640 GPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETSGISS 699
            P +SS D A    + S+ S  S  +  ++S  P S     +    SAS  SP + G   
Sbjct: 576 WPSVSSLDSA----LESSPSLHSPADPSHLS-PPASSPRPSRGHRRSASCGSPLSGGAEE 630

Query: 700 ASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCIIRVSLDV-DNGNM 758
           AS  T      + P A+                          DC IIRV +++ ++G++
Sbjct: 631 ASGGTGYGGEGSGPGAS--------------------------DCRIIRVQMELGEDGSV 664

Query: 759 YKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPENANVFYAMNST 818
           YKSILVTSQDKAP+VI + + K+N +     +YEL+Q+L  +R+L IP +ANVFYAM+  
Sbjct: 665 YKSILVTSQDKAPSVISRVLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYAMDG- 723

Query: 819 ANYDFVLKKR----TFTKGVKVKHGASST---------LPRMKQKGLKIAKGIF 859
           A++DF+L++R    T T GV     AS T          PR+K  G KIA+ +F
Sbjct: 724 ASHDFLLRQRRRSSTATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF 777



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 37/103 (35%), Positives = 55/103 (53%), Gaps = 22/103 (21%)

Query: 59  RTVKAGTLEKLVEHLVPA-FQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTA 117
           R ++AGTLE LV HL+     G+D+S+++ FL T+RAFT+T  +L L+     R +AL  
Sbjct: 90  RRLRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLM---ADRLEAL-- 144

Query: 118 SSRYGCILPYSDEDGGPQDQLKNAIS---SILGTWLDQYSEDF 157
                        +  P D+L+       S+L TWL  + EDF
Sbjct: 145 -------------ESHPTDELERTTEVAISVLSTWLASHPEDF 174


>gi|23957680 ral guanine nucleotide dissociation stimulator-like 4
           [Homo sapiens]
          Length = 473

 Score =  329 bits (844), Expect = 6e-90
 Identities = 201/472 (42%), Positives = 266/472 (56%), Gaps = 47/472 (9%)

Query: 121 YGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGS 180
           YG + P+ D   G +      I+SIL  W  + +  + QPP     +  +A+  L+ PG 
Sbjct: 46  YGQVCPFQDSTDGLR-----TITSILFNWPPENTSVYYQPPQRSSFRIKLAFRNLSWPGL 100

Query: 181 DLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEP 240
            LE    ++L QL   EP EA+P+                       P+P P       P
Sbjct: 101 GLEDHQEIVLGQLVLPEPNEAKPDD----------------------PAPRPGQHALTMP 138

Query: 241 APTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAP 300
           A  PAP    ++ PA  PE   A  P   L SAP PA    PAP + P P   LE + AP
Sbjct: 139 ALEPAPPLLADLGPALEPESPAALGPPGYLHSAPGPA----PAPGEGPPPGTVLEPQSAP 194

Query: 301 APVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIW 360
                 + S P     +N  SEE P +  FPP L+AEQ TLMDAELFKKVV + CLG IW
Sbjct: 195 ------ESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIW 248

Query: 361 SQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRI 420
            Q   KG EH+APT+RAT+  FN + NC+ T+CLG+ S +A DRARVVEHWI+VAREC  
Sbjct: 249 GQGHLKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLS 308

Query: 421 LKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKE 480
           L NFSS++ I+SAL SN I +L KTW  VS  S +  ++L      + + ++ R+LLIK 
Sbjct: 309 LNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELC-----KKDTAVKRDLLIKA 363

Query: 481 GTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKR 540
           G+ K AT E NP+R Q R +     +G VP+LG FLT+L  LD+A+ D L G   N  KR
Sbjct: 364 GSFKVATQERNPQRVQMRLRRQK--KGVVPFLGDFLTELQRLDSAIPDDLDG---NTNKR 418

Query: 541 RKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEP 592
            KE  V+ +++LLQ A  NY + P E+F  +F  +E+LS+ ESY LSC+LEP
Sbjct: 419 SKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRMEQLSDKESYKLSCQLEP 470


>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
           sapiens]
          Length = 557

 Score =  119 bits (298), Expect = 1e-26
 Identities = 108/402 (26%), Positives = 178/402 (44%), Gaps = 60/402 (14%)

Query: 327 LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVA 386
           +L   P+  A Q TLMD  +FK + P       WS   KK K  LAP + A   +FN V+
Sbjct: 46  VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWS---KKEKHSLAPNVVAFTRRFNQVS 102

Query: 387 NCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTW 446
             V+   L  ++ K   RA ++ H++++A++   L N  SL +++SALQS  I RL KTW
Sbjct: 103 FWVVREILTAQTLKI--RAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTW 160

Query: 447 EDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQ 506
             ++R     F+KL  + S E+NY  +RE +         +L+M P              
Sbjct: 161 ALLNRKDKTTFEKLDYLMSKEDNYKRTREYI--------RSLKMVP-------------- 198

Query: 507 GTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKL-LQSACNNYSIAPD 565
            ++PYLG +L DL+ +D+A      G ++  E+R  +   I +I   LQ +C+   +   
Sbjct: 199 -SIPYLGIYLLDLIYIDSAYP--ASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTL 255

Query: 566 EQFGAWFRAV------ERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAP 619
                + ++V      ++  E ++Y LS  +EP S S            +V    D   P
Sbjct: 256 PHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSS----------PRLVSSKEDLAGP 305

Query: 620 STELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSS----SDVEEINISFVPES 675
           S    ++  S   +C        L +  +      HS G++     S VE  + +F  E 
Sbjct: 306 SAGSGSARFSRRPTCPDTSVAGSLPTPPVPRHRKSHSLGNNMMCQLSVVESKSATFPSEK 365

Query: 676 P---------DGQEKKFWESASQSSPETSGISSASSSTSSSS 708
                     + +  +   + + SS  T+G+S  SS +S  S
Sbjct: 366 ARHLLDDSVLESRSPRRGLALTSSSAVTNGLSLGSSESSEFS 407


>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
            2 [Homo sapiens]
          Length = 1237

 Score =  107 bits (268), Expect = 4e-23
 Identities = 75/259 (28%), Positives = 119/259 (45%), Gaps = 32/259 (12%)

Query: 335  VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 394
            +AEQ TL+D  +F+ +     LG  W + DK  +    P I  T   FN ++N V +  +
Sbjct: 1006 LAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNER---TPYIMKTSQHFNDMSNLVASQIM 1062

Query: 395  GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 454
                  +  RA  +E W+ VA  CR L N++ +  I SAL  ++I+RLKKTW  VS+ + 
Sbjct: 1063 NYADVSS--RANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120

Query: 455  RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 514
             +  KL +  S E  +   RE L             NP                VPYLG 
Sbjct: 1121 ALMDKLQKTVSSEGRFKNLRETL----------KNCNPP--------------AVPYLGM 1156

Query: 515  FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 574
            +LTDL  ++    ++    L+NF K R    +I +I+  Q    +Y I    +   +   
Sbjct: 1157 YLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQ--TSYRIDHQPKVAQYLLD 1214

Query: 575  VERLSETES-YNLSCELEP 592
             + + + ++ Y LS ++EP
Sbjct: 1215 KDLIIDEDTLYELSLKIEP 1233



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 69/290 (23%), Positives = 113/290 (38%), Gaps = 47/290 (16%)

Query: 55  TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDA 114
           +CKV  ++  ++E+L+E L    +   + ++  FL TYR FTT   VL  L   Y R   
Sbjct: 633 SCKVPQIRYASVERLLERLTD-LRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIYKR--P 689

Query: 115 LTASSRYGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQ 174
            T+       L ++       + L +  S  L          F  PP           + 
Sbjct: 690 FTSIPVRSLELFFATSQNNRGEHLVDGKSPRL-------CRKFSSPPP----------LA 732

Query: 175 LNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSP---- 230
           ++   S +  R      +L  + P+ ++  AL    +  PT   +   +PA +P P    
Sbjct: 733 VSRTSSPVRAR------KLSLTSPLNSKIGALDLTTSSSPTTTTQ---SPAASPPPHTGQ 783

Query: 231 VPAPAPEPEPAPTPAPGSELEVAPAP----APELQQAPEPAVGLESAPAPALELEPAPEQ 286
           +P        +P  +PG+  E    P      +L+++ + AV LESAPA    +E +P  
Sbjct: 784 IPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAV-LESAPADRAGVESSPAA 842

Query: 287 DPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLLVFPPDLVA 336
           D     T EL P  +P       +  P     G + +  H  V P    A
Sbjct: 843 D-----TTELSPCRSPSTPRHLRYRQP----GGQTADNAHCSVSPASAFA 883


>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 3 [Homo sapiens]
          Length = 1257

 Score =  105 bits (263), Expect = 1e-22
 Identities = 74/259 (28%), Positives = 116/259 (44%), Gaps = 32/259 (12%)

Query: 335  VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 394
            +AEQ TL+D  +FKK+      G  W + +K  +    P I  T   FN ++N + +  +
Sbjct: 1026 IAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEII 1082

Query: 395  GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 454
             N    A  R   +E W+ VA  CR L N++++  I S++  ++I RLKKTW  VS+ + 
Sbjct: 1083 RNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1140

Query: 455  RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 514
             +  KL ++ S E  +   RE L             +P                VPYLG 
Sbjct: 1141 ALIDKLQKLVSSEGRFKNLREAL----------KNCDPP--------------CVPYLGM 1176

Query: 515  FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 574
            +LTDL  ++    +Y    L+NF K R    +I +I+  Q     Y I    +   +   
Sbjct: 1177 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLD 1234

Query: 575  VERLSETES-YNLSCELEP 592
               + + ES Y  S  +EP
Sbjct: 1235 QSFVMDEESLYESSLRIEP 1253



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 55  TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRY 109
           +CKV  ++  ++E+L+E L    +   + ++  FL +YR FTT   VLD L   Y
Sbjct: 629 SCKVLQIRYASVERLLERLTD-LRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIY 682


>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
            1 isoform 1 [Homo sapiens]
          Length = 1273

 Score =  105 bits (263), Expect = 1e-22
 Identities = 74/259 (28%), Positives = 116/259 (44%), Gaps = 32/259 (12%)

Query: 335  VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 394
            +AEQ TL+D  +FKK+      G  W + +K  +    P I  T   FN ++N + +  +
Sbjct: 1042 IAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEII 1098

Query: 395  GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 454
             N    A  R   +E W+ VA  CR L N++++  I S++  ++I RLKKTW  VS+ + 
Sbjct: 1099 RNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 1156

Query: 455  RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 514
             +  KL ++ S E  +   RE L             +P                VPYLG 
Sbjct: 1157 ALIDKLQKLVSSEGRFKNLREAL----------KNCDPP--------------CVPYLGM 1192

Query: 515  FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 574
            +LTDL  ++    +Y    L+NF K R    +I +I+  Q     Y I    +   +   
Sbjct: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLD 1250

Query: 575  VERLSETES-YNLSCELEP 592
               + + ES Y  S  +EP
Sbjct: 1251 QSFVMDEESLYESSLRIEP 1269



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 55  TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRY 109
           +CKV  ++  ++E+L+E L    +   + ++  FL +YR FTT   VLD L   Y
Sbjct: 642 SCKVLQIRYASVERLLERLTD-LRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIY 695


>gi|24797101 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 2 [Homo sapiens]
          Length = 489

 Score =  105 bits (263), Expect = 1e-22
 Identities = 74/259 (28%), Positives = 116/259 (44%), Gaps = 32/259 (12%)

Query: 335 VAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCL 394
           +AEQ TL+D  +FKK+      G  W + +K  +    P I  T   FN ++N + +  +
Sbjct: 258 IAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNER---TPYIMKTTKHFNDISNLIASEII 314

Query: 395 GNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSF 454
            N    A  R   +E W+ VA  CR L N++++  I S++  ++I RLKKTW  VS+ + 
Sbjct: 315 RNEDINA--RVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTK 372

Query: 455 RIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGT 514
            +  KL ++ S E  +   RE L             +P                VPYLG 
Sbjct: 373 ALIDKLQKLVSSEGRFKNLREAL----------KNCDPP--------------CVPYLGM 408

Query: 515 FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRA 574
           +LTDL  ++    +Y    L+NF K R    +I +I+  Q     Y I    +   +   
Sbjct: 409 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTA--YKIEHQAKVTQYLLD 466

Query: 575 VERLSETES-YNLSCELEP 592
              + + ES Y  S  +EP
Sbjct: 467 QSFVMDEESLYESSLRIEP 485


>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
           sapiens]
          Length = 583

 Score =  100 bits (250), Expect = 4e-21
 Identities = 80/272 (29%), Positives = 129/272 (47%), Gaps = 36/272 (13%)

Query: 327 LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVA 386
           +L   P+  A Q TLMD  +FK + P       W++++K      AP   A   +FN V+
Sbjct: 45  VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSS---APNAVAFTRRFNHVS 101

Query: 387 NCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTW 446
             V+   L  ++ K   RA V+ H+I+ A++   L N  +L A++S LQS  I RL KTW
Sbjct: 102 FWVVREILHAQTLKI--RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTW 159

Query: 447 EDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQ 506
             +SR     F+KL  + S E+NY   R+ +        ++L+M P              
Sbjct: 160 ALLSRKDKTTFEKLEYVMSKEDNYKRLRDYI--------SSLKMTP-------------- 197

Query: 507 GTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQI--KLLQSACNNYSIAP 564
             +PYLG +L+DL  +D+A      G ++  E+R      I +I   L QS   +  + P
Sbjct: 198 -CIPYLGIYLSDLTYIDSAYPS--TGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLP 254

Query: 565 DEQ----FGAWFRAVERLSETESYNLSCELEP 592
             Q       +   +++  E ++Y LS ++EP
Sbjct: 255 HVQKYLNSVQYIEELQKFVEDDNYKLSLKIEP 286


>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
          Length = 1332

 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 72/275 (26%), Positives = 124/275 (45%), Gaps = 41/275 (14%)

Query: 327  LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKK-GKEHLAPTIRATVTQFNSV 385
            L+   P  +A Q TL++++L++KV P   +GS+W++ DK+    +L   IR T       
Sbjct: 774  LMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 833

Query: 386  ANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKT 445
              C++       +    +R  V+   IE+ +  + L NF+ +  I+SA+ S S++RL  T
Sbjct: 834  EKCIV------EAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHT 887

Query: 446  WEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGII 505
            +E +     +I  +  E+  D       ++ L+K          +NP             
Sbjct: 888  FEALQERKRKILDEAVELSQDH-----FKKYLVK-------LKSINPP------------ 923

Query: 506  QGTVPYLGTFLTDLVMLDTAMKDYLYGR---LINFEKRRKEFEVIAQIKLLQSACNNYSI 562
               VP+ G +LT+++  +    D+L  +   LINF KRRK  E+  +I+  Q+      I
Sbjct: 924  --CVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRI 981

Query: 563  APD-----EQFGAWFRAVERLSETESYNLSCELEP 592
             PD     E       A E+      +N S E+EP
Sbjct: 982  EPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEP 1016



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 22/59 (37%), Positives = 34/59 (57%), Gaps = 1/59 (1%)

Query: 51  NLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRY 109
           NL     +  +K GT+ KL+E L      +D ++V  FL TYR+F   Q++L LL +R+
Sbjct: 589 NLQSRSGIPIIKGGTVVKLIERLTYHMY-ADPNFVRTFLTTYRSFCKPQELLSLLIERF 646


>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
            sapiens]
          Length = 1095

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 79/295 (26%), Positives = 135/295 (45%), Gaps = 40/295 (13%)

Query: 312  SPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHL 371
            S  +A  G++     L  F    +AEQ TL+DAELF K+     L  +W+   K+  E  
Sbjct: 839  SQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWA---KEQNEEK 893

Query: 372  APTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAIL 431
            +P +      FN+++  V +  +     KA DR R++  +I++ +  R L NF+S  AIL
Sbjct: 894  SPNLTQFTEHFNNMSYWVRSIIM--LQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAIL 951

Query: 432  SALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN 491
            SAL S  I RL+  W+  + +    +  L +  S    Y             + A  E+ 
Sbjct: 952  SALDSAPIRRLE--WQKQTSEGLAEYCTLIDSSSSFRAY-------------RAALSEVE 996

Query: 492  PKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIK 551
            P                +PYLG  L DL  +     DY+ G+ +NF KR ++F ++  ++
Sbjct: 997  PP--------------CIPYLGLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMR 1041

Query: 552  LLQSACNNYSIAPDEQFGAWFRAV-ERLSETESYNLSCELEPPSESASNTLRTKK 605
              Q A  +Y +  ++    +F    + L+E   + LS +++P + +   T R +K
Sbjct: 1042 CFQQA--HYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEK 1094



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 27/97 (27%), Positives = 40/97 (41%), Gaps = 3/97 (3%)

Query: 218 LELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPA 277
           + L +     PSP  +P     PA  P   +EL +       L +    +   E  P  A
Sbjct: 221 VRLTIEKQGRPSPT-SPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLP-DA 278

Query: 278 LELEPAPEQDPAPS-QTLELEPAPAPVPSLQPSWPSP 313
            + E AP + P P  + ++  P PA  P  + S PSP
Sbjct: 279 TDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSP 315


>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
            sapiens]
          Length = 1077

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 79/295 (26%), Positives = 135/295 (45%), Gaps = 40/295 (13%)

Query: 312  SPVVAENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHL 371
            S  +A  G++     L  F    +AEQ TL+DAELF K+     L  +W+   K+  E  
Sbjct: 821  SQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWA---KEQNEEK 875

Query: 372  APTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAIL 431
            +P +      FN+++  V +  +     KA DR R++  +I++ +  R L NF+S  AIL
Sbjct: 876  SPNLTQFTEHFNNMSYWVRSIIM--LQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAIL 933

Query: 432  SALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN 491
            SAL S  I RL+  W+  + +    +  L +  S    Y             + A  E+ 
Sbjct: 934  SALDSAPIRRLE--WQKQTSEGLAEYCTLIDSSSSFRAY-------------RAALSEVE 978

Query: 492  PKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIK 551
            P                +PYLG  L DL  +     DY+ G+ +NF KR ++F ++  ++
Sbjct: 979  PP--------------CIPYLGLILQDLTFVHLGNPDYIDGK-VNFSKRWQQFNILDSMR 1023

Query: 552  LLQSACNNYSIAPDEQFGAWFRAV-ERLSETESYNLSCELEPPSESASNTLRTKK 605
              Q A  +Y +  ++    +F    + L+E   + LS +++P + +   T R +K
Sbjct: 1024 CFQQA--HYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPRNITRRKTDREEK 1076



 Score = 32.3 bits (72), Expect = 1.9
 Identities = 27/97 (27%), Positives = 40/97 (41%), Gaps = 3/97 (3%)

Query: 218 LELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPA 277
           + L +     PSP  +P     PA  P   +EL +       L +    +   E  P  A
Sbjct: 203 VRLTIEKQGRPSPT-SPVKPSSPASKPDGPAELPLTDREVEILNKTTGMSQSTELLP-DA 260

Query: 278 LELEPAPEQDPAPS-QTLELEPAPAPVPSLQPSWPSP 313
            + E AP + P P  + ++  P PA  P  + S PSP
Sbjct: 261 TDEEVAPPKPPLPGIRVVDNSPPPALPPKKRQSAPSP 297


>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
          Length = 1333

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 68/275 (24%), Positives = 123/275 (44%), Gaps = 41/275 (14%)

Query: 327  LLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKK-GKEHLAPTIRATVTQFNSV 385
            LL   P  +A Q TL++++L++ V P   +GS+W++ DK+    +L   IR T       
Sbjct: 776  LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 835

Query: 386  ANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKT 445
              C++ T          +R  VV   IE+ +  + L NF+ +  ++SA+ S+ ++RL  T
Sbjct: 836  EKCIVET------ENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHT 889

Query: 446  WEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGII 505
            +E +     +I ++  E+  D     L++               +NP             
Sbjct: 890  FEQIPSRQKKILEEAHELSEDHYKKYLAK------------LRSINPP------------ 925

Query: 506  QGTVPYLGTFLTDLVMLDTAMKDYL--YGR-LINFEKRRKEFEVIAQIKLLQSACNNYSI 562
               VP+ G +LT+++  +    + L  +G+ LINF KRRK  E+  +I+  Q+      +
Sbjct: 926  --CVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRV 983

Query: 563  APD-----EQFGAWFRAVERLSETESYNLSCELEP 592
              D     E       ++E+      +N S E+EP
Sbjct: 984  ESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEP 1018



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 35/139 (25%), Positives = 63/139 (45%), Gaps = 18/139 (12%)

Query: 51  NLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYG 110
           N+     +  +KAGT+ KL+E L      +D ++V  FL TYR+F   Q++L L+ +R+ 
Sbjct: 591 NMQPKAGIPIIKAGTVIKLIERLTYHMY-ADPNFVRTFLTTYRSFCKPQELLSLIIERFE 649

Query: 111 RCDALTASSRYGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLV 170
                         +P  +     +  ++N     L   L ++ +++ QP     L    
Sbjct: 650 --------------IPEPEPTEADRIAIENG-DQPLSAELKRFRKEYIQPVQLRVLNVCR 694

Query: 171 AYVQLNMPGSDLERRAHLL 189
            +V+ +    D ER A+LL
Sbjct: 695 HWVEHHF--YDFERDAYLL 711


>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 78/324 (24%), Positives = 137/324 (42%), Gaps = 44/324 (13%)

Query: 310 WPSPVVAENGLSEEKPHL-LVFP---PDLVAEQFTLMDAELFKKVV--PYHCLGSIWSQR 363
           W   V   N + ++K  + L+F    P  +AE  T ++   F K++   YH   +     
Sbjct: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188

Query: 364 DKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKN 423
           D        P +   ++ FNSV+  V    L   +  AP RA V+ H++ VA +   L+N
Sbjct: 189 DN-------PVLERFISLFNSVSQWVQLMILSKPT--APQRALVITHFVHVAEKLLQLQN 239

Query: 424 FSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTS 483
           F++L A++  L  +SI RLK+T   VS ++ ++++ L+E+ +   NY   R  L      
Sbjct: 240 FNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRL------ 293

Query: 484 KFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYL--YGRLINFEKRR 541
                                +    P LG  L DLV L  A+ D+L      +N  K +
Sbjct: 294 ------------------AACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335

Query: 542 KEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSES---AS 598
           + F ++ ++ ++ S        PD          +  +E E Y LS + EP S+S   + 
Sbjct: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395

Query: 599 NTLRTKKNTAIVKRWSDRQAPSTE 622
            +        +++ W+    P  +
Sbjct: 396 TSCTPPPRPPVLEEWTSAAKPKLD 419


>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 78/324 (24%), Positives = 137/324 (42%), Gaps = 44/324 (13%)

Query: 310 WPSPVVAENGLSEEKPHL-LVFP---PDLVAEQFTLMDAELFKKVV--PYHCLGSIWSQR 363
           W   V   N + ++K  + L+F    P  +AE  T ++   F K++   YH   +     
Sbjct: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188

Query: 364 DKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKN 423
           D        P +   ++ FNSV+  V    L   +  AP RA V+ H++ VA +   L+N
Sbjct: 189 DN-------PVLERFISLFNSVSQWVQLMILSKPT--APQRALVITHFVHVAEKLLQLQN 239

Query: 424 FSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTS 483
           F++L A++  L  +SI RLK+T   VS ++ ++++ L+E+ +   NY   R  L      
Sbjct: 240 FNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRL------ 293

Query: 484 KFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYL--YGRLINFEKRR 541
                                +    P LG  L DLV L  A+ D+L      +N  K +
Sbjct: 294 ------------------AACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335

Query: 542 KEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSES---AS 598
           + F ++ ++ ++ S        PD          +  +E E Y LS + EP S+S   + 
Sbjct: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395

Query: 599 NTLRTKKNTAIVKRWSDRQAPSTE 622
            +        +++ W+    P  +
Sbjct: 396 TSCTPPPRPPVLEEWTSAAKPKLD 419


>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
          Length = 609

 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 78/324 (24%), Positives = 137/324 (42%), Gaps = 44/324 (13%)

Query: 310 WPSPVVAENGLSEEKPHL-LVFP---PDLVAEQFTLMDAELFKKVV--PYHCLGSIWSQR 363
           W   V   N + ++K  + L+F    P  +AE  T ++   F K++   YH   +     
Sbjct: 129 WKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFVTHGCTV 188

Query: 364 DKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKN 423
           D        P +   ++ FNSV+  V    L   +  AP RA V+ H++ VA +   L+N
Sbjct: 189 DN-------PVLERFISLFNSVSQWVQLMILSKPT--APQRALVITHFVHVAEKLLQLQN 239

Query: 424 FSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTS 483
           F++L A++  L  +SI RLK+T   VS ++ ++++ L+E+ +   NY   R  L      
Sbjct: 240 FNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRL------ 293

Query: 484 KFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYL--YGRLINFEKRR 541
                                +    P LG  L DLV L  A+ D+L      +N  K +
Sbjct: 294 ------------------AACVGFRFPILGVHLKDLVALQLALPDWLDPARTRLNGAKMK 335

Query: 542 KEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLSCELEPPSES---AS 598
           + F ++ ++ ++ S        PD          +  +E E Y LS + EP S+S   + 
Sbjct: 336 QLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQREPRSKSSPTSP 395

Query: 599 NTLRTKKNTAIVKRWSDRQAPSTE 622
            +        +++ W+    P  +
Sbjct: 396 TSCTPPPRPPVLEEWTSAAKPKLD 419


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 58/143 (40%), Positives = 63/143 (44%), Gaps = 13/143 (9%)

Query: 197 EPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPA--PEPEPAPTPAPGSELEVAP 254
           EPI      L+P P  + T E    L     P P   PA  P PEPA  PAP    E AP
Sbjct: 52  EPIPEPCPELAPGPCPEATSESATELYTEPTPEPATEPASEPAPEPATEPAPEPATEPAP 111

Query: 255 APAPE--LQQAPEPAVGLESAPAPALEL--EPAPEQDPAPSQTLELEPAPAPVPSLQPSW 310
            PAPE   + APEP       P PALE   EPAPE  P  +  L  EP P PV  L P +
Sbjct: 112 EPAPEPATESAPEP------TPEPALESVPEPAPELTPEVAPELAPEPTPEPVTELAPEF 165

Query: 311 PSPVVAENGLSEEKPHLLVFPPD 333
             P  A        P LL  P D
Sbjct: 166 -CPEAAPEFRPSPAPCLLQCPVD 187



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 52/131 (39%), Positives = 59/131 (45%), Gaps = 6/131 (4%)

Query: 208 PVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPA 267
           P PA  P P L    +P   P P P  AP P P  T    +EL   P P P  + A EPA
Sbjct: 35  PPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSESATELYTEPTPEPATEPASEPA 94

Query: 268 VGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHL 327
               + PAP    EPAPE  PAP    E  P P P P+L+ S P P  A     E  P L
Sbjct: 95  PEPATEPAPEPATEPAPE--PAPEPATESAPEPTPEPALE-SVPEP--APELTPEVAPEL 149

Query: 328 LVFP-PDLVAE 337
              P P+ V E
Sbjct: 150 APEPTPEPVTE 160



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 50/131 (38%), Positives = 58/131 (44%), Gaps = 22/131 (16%)

Query: 197 EPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAP 256
           EP        +P PA +P PE   A  PA  P P P PA E  P PTP P   LE  P P
Sbjct: 84  EPATEPASEPAPEPATEPAPEP--ATEPA--PEPAPEPATESAPEPTPEPA--LESVPEP 137

Query: 257 APELQQAPEPAVGLESAPAPALELEP------APEQDPAPSQTL----------ELEPAP 300
           APEL     P +  E  P P  EL P      APE  P+P+  L           L+ +P
Sbjct: 138 APELTPEVAPELAPEPTPEPVTELAPEFCPEAAPEFRPSPAPCLLQCPVDTRERGLKTSP 197

Query: 301 APVPSLQPSWP 311
           +P PS  P  P
Sbjct: 198 SPSPSPSPRTP 208



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 51/156 (32%), Positives = 63/156 (40%), Gaps = 27/156 (17%)

Query: 224 PARAPSPVPAPAPEPE-------PAPTPAP----GSELEVAPAPAPELQQAPEPAVGLES 272
           P     P  +P P P        PAP PAP     +  E  P P PEL   P P    ES
Sbjct: 14  PQDGEQPAESPEPPPPWPPPPPPPAPPPAPPLLSEASPEPIPEPCPELAPGPCPEATSES 73

Query: 273 A--------PAPALE--LEPAPE--QDPAPSQTLELEPAPAPVPSLQPS-WPSPVVAENG 319
           A        P PA E   EPAPE   +PAP    E  P PAP P+ + +  P+P  A   
Sbjct: 74  ATELYTEPTPEPATEPASEPAPEPATEPAPEPATEPAPEPAPEPATESAPEPTPEPALES 133

Query: 320 LSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHC 355
           + E  P L    P++  E       E   ++ P  C
Sbjct: 134 VPEPAPEL---TPEVAPELAPEPTPEPVTELAPEFC 166


>gi|33186895 selenoprotein V [Homo sapiens]
          Length = 346

 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 50/134 (37%), Positives = 60/134 (44%), Gaps = 23/134 (17%)

Query: 198 PIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEV----- 252
           P  A+   L P PAL   P L     PA  P+PVP P P   P P P P   L       
Sbjct: 64  PAPAQIPTLVPTPALARIPRLVPPPAPAWIPTPVPTPVPVRNPTPVPTPARTLTPPVRVP 123

Query: 253 APAPA----------PELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLEL------ 296
           APAPA          P L     PA+ L+  P PA EL   PE+DP P+ +L+L      
Sbjct: 124 APAPAQLLAGIRAALPVLDSYLAPALPLDPPPEPAPELPLLPEEDPEPAPSLKLIPSVSS 183

Query: 297 --EPAPAPVPSLQP 308
              PAP P+P+  P
Sbjct: 184 EAGPAPGPLPTRTP 197



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 41/131 (31%), Positives = 49/131 (37%), Gaps = 23/131 (17%)

Query: 207 SPVPALKPTPELELALT---PARAPSPVPA------------------PAPEPEPAPTPA 245
           +PVP   PTP    A T   P R P+P PA                  PA   +P P PA
Sbjct: 99  TPVPVRNPTPVPTPARTLTPPVRVPAPAPAQLLAGIRAALPVLDSYLAPALPLDPPPEPA 158

Query: 246 PGSEL--EVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPV 303
           P   L  E  P PAP L+  P  +     AP P     P     P P+        P+ +
Sbjct: 159 PELPLLPEEDPEPAPSLKLIPSVSSEAGPAPGPLPTRTPLAANSPGPTLDFTFRADPSAI 218

Query: 304 PSLQPSWPSPV 314
               P  PSPV
Sbjct: 219 GLADPPIPSPV 229



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 48/164 (29%), Positives = 64/164 (39%), Gaps = 22/164 (13%)

Query: 204 EALSPVPALKPTPELELALTPARAPSPVPAPAP----------EPEPAPTPAPGSELEVA 253
           +A +P P+   T     A TP R P+P+  P P           P   P+PA  S L + 
Sbjct: 4   QARTPAPSSARTSTSVRASTPTRTPTPLRTPTPVRTRTPIRTLTPVLTPSPAGTSPLVLT 63

Query: 254 PAPAPELQQAPEPAVG----LESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPS 309
           PAPA      P PA+     L   PAPA    P P   P  + T    PA    P ++  
Sbjct: 64  PAPAQIPTLVPTPALARIPRLVPPPAPAWIPTPVPTPVPVRNPTPVPTPARTLTPPVRVP 123

Query: 310 WPSPVVAENGL--------SEEKPHLLVFPPDLVAEQFTLMDAE 345
            P+P     G+        S   P L + PP   A +  L+  E
Sbjct: 124 APAPAQLLAGIRAALPVLDSYLAPALPLDPPPEPAPELPLLPEE 167



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 37/154 (24%), Positives = 60/154 (38%), Gaps = 31/154 (20%)

Query: 164 PCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSPVPAL-----KPTPEL 218
           P   QL+A ++  +P  D         + L  + P++  PE    +P L     +P P L
Sbjct: 125 PAPAQLLAGIRAALPVLD---------SYLAPALPLDPPPEPAPELPLLPEEDPEPAPSL 175

Query: 219 ELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPAL 278
           +L  + +    P P P P   P    +PG  L+          +A   A+GL   P P+ 
Sbjct: 176 KLIPSVSSEAGPAPGPLPTRTPLAANSPGPTLDFT-------FRADPSAIGLADPPIPS- 227

Query: 279 ELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPS 312
                    P PS  L   P+   + +   ++PS
Sbjct: 228 ---------PVPSPILGTIPSAISLQNCTETFPS 252


>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
            I [Homo sapiens]
          Length = 1601

 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 61/243 (25%), Positives = 103/243 (42%), Gaps = 33/243 (13%)

Query: 316  AENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTI 375
            A+  + E +  +L      VA Q ++ D +LF+ + P   +  ++    K G  HL    
Sbjct: 845  AQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHLK--- 901

Query: 376  RATVTQFNSVANCVITTCLGNRSTKAPD--RARVVEHWIEVARECRILKNFSSLYAILSA 433
                 +F  + N           T+A    R ++++H+I++A  CR  KNF+S++AI+S 
Sbjct: 902  -----RFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISG 956

Query: 434  LQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPK 493
            L   S+ RL+ TWE +     +  Q L +IF    N +  R +L        ++  M P 
Sbjct: 957  LNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNIL--------SSQSMQPP 1008

Query: 494  RAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLL 553
                           +P       D+  L       + G L+NFEK R   + I Q+  +
Sbjct: 1009 --------------IIPLFPVVKKDMTFLHEGNDSKVDG-LVNFEKLRMISKEIRQVVRM 1053

Query: 554  QSA 556
             SA
Sbjct: 1054 TSA 1056



 Score = 30.4 bits (67), Expect = 7.3
 Identities = 18/61 (29%), Positives = 29/61 (47%)

Query: 55  TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDA 114
           T K   V   T E+L+ HL+      D +Y+  FL TYR F  +   + +    + + D+
Sbjct: 410 TRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDS 469

Query: 115 L 115
           L
Sbjct: 470 L 470


>gi|169790903 cyclin-dependent kinase inhibitor 1C isoform b [Homo
           sapiens]
          Length = 305

 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 53/134 (39%), Positives = 62/134 (46%), Gaps = 22/134 (16%)

Query: 194 EHSEPIEAEPEALSPVPALKPTPELELALTPARAP--SPVPAPAPEPEPAPTPAPGSELE 251
           E  + +E  PE L  VP   P      A TP   P  +P PAPAP P  AP  AP +   
Sbjct: 113 ESLDGLEEAPEQLPSVPVPAP------ASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAV 166

Query: 252 VAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWP 311
           +APAPAP    AP PA     APAP     PAP   PAP+      PAPAP P   P   
Sbjct: 167 LAPAPAP----APAPA----PAPAPVAAPAPAPAPAPAPA------PAPAPAPDAAPQES 212

Query: 312 SPVVAENGLSEEKP 325
           +   A  G   ++P
Sbjct: 213 AEQGANQGQRGQEP 226



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 48/147 (32%), Positives = 59/147 (40%), Gaps = 44/147 (29%)

Query: 198 PIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPA 257
           P+ A   A   V  L P P    A  PA AP+PV APAP P PAP PAP      APAPA
Sbjct: 153 PVAAPVAAPVAVAVLAPAPAP--APAPAPAPAPVAAPAPAPAPAPAPAP------APAPA 204

Query: 258 PEL--QQAPE------------------------PAVGLESAPAPALELEP--------- 282
           P+   Q++ E                        PA G  +A A    ++          
Sbjct: 205 PDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKLSGPLISDF 264

Query: 283 -APEQDPAPSQTLELEPAPAPVPSLQP 308
            A  +  AP ++    PAP P PS  P
Sbjct: 265 FAKRKRSAPEKSSGDVPAPCPSPSAAP 291



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 39/99 (39%), Positives = 44/99 (44%), Gaps = 15/99 (15%)

Query: 227 APSPVP---APAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPA 283
           AP PV    A +P  EPA     G  LE AP   P +   P PA      P P L   PA
Sbjct: 94  APRPVAVAVAVSPPLEPAAESLDG--LEEAPEQLPSV---PVPAPASTPPPVPVLAPAPA 148

Query: 284 PEQDP------APSQTLELEPAPAPVPSLQPSWPSPVVA 316
           P   P      AP     L PAPAP P+  P+ P+PV A
Sbjct: 149 PAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPA-PAPVAA 186


>gi|169790899 cyclin-dependent kinase inhibitor 1C isoform b [Homo
           sapiens]
          Length = 305

 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 53/134 (39%), Positives = 62/134 (46%), Gaps = 22/134 (16%)

Query: 194 EHSEPIEAEPEALSPVPALKPTPELELALTPARAP--SPVPAPAPEPEPAPTPAPGSELE 251
           E  + +E  PE L  VP   P      A TP   P  +P PAPAP P  AP  AP +   
Sbjct: 113 ESLDGLEEAPEQLPSVPVPAP------ASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAV 166

Query: 252 VAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWP 311
           +APAPAP    AP PA     APAP     PAP   PAP+      PAPAP P   P   
Sbjct: 167 LAPAPAP----APAPA----PAPAPVAAPAPAPAPAPAPA------PAPAPAPDAAPQES 212

Query: 312 SPVVAENGLSEEKP 325
           +   A  G   ++P
Sbjct: 213 AEQGANQGQRGQEP 226



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 48/147 (32%), Positives = 59/147 (40%), Gaps = 44/147 (29%)

Query: 198 PIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPA 257
           P+ A   A   V  L P P    A  PA AP+PV APAP P PAP PAP      APAPA
Sbjct: 153 PVAAPVAAPVAVAVLAPAPAP--APAPAPAPAPVAAPAPAPAPAPAPAP------APAPA 204

Query: 258 PEL--QQAPE------------------------PAVGLESAPAPALELEP--------- 282
           P+   Q++ E                        PA G  +A A    ++          
Sbjct: 205 PDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKLSGPLISDF 264

Query: 283 -APEQDPAPSQTLELEPAPAPVPSLQP 308
            A  +  AP ++    PAP P PS  P
Sbjct: 265 FAKRKRSAPEKSSGDVPAPCPSPSAAP 291



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 39/99 (39%), Positives = 44/99 (44%), Gaps = 15/99 (15%)

Query: 227 APSPVP---APAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPA 283
           AP PV    A +P  EPA     G  LE AP   P +   P PA      P P L   PA
Sbjct: 94  APRPVAVAVAVSPPLEPAAESLDG--LEEAPEQLPSV---PVPAPASTPPPVPVLAPAPA 148

Query: 284 PEQDP------APSQTLELEPAPAPVPSLQPSWPSPVVA 316
           P   P      AP     L PAPAP P+  P+ P+PV A
Sbjct: 149 PAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPA-PAPVAA 186


>gi|4557441 cyclin-dependent kinase inhibitor 1C isoform a [Homo
           sapiens]
          Length = 316

 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 53/134 (39%), Positives = 62/134 (46%), Gaps = 22/134 (16%)

Query: 194 EHSEPIEAEPEALSPVPALKPTPELELALTPARAP--SPVPAPAPEPEPAPTPAPGSELE 251
           E  + +E  PE L  VP   P      A TP   P  +P PAPAP P  AP  AP +   
Sbjct: 124 ESLDGLEEAPEQLPSVPVPAP------ASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAV 177

Query: 252 VAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWP 311
           +APAPAP    AP PA     APAP     PAP   PAP+      PAPAP P   P   
Sbjct: 178 LAPAPAP----APAPA----PAPAPVAAPAPAPAPAPAPA------PAPAPAPDAAPQES 223

Query: 312 SPVVAENGLSEEKP 325
           +   A  G   ++P
Sbjct: 224 AEQGANQGQRGQEP 237



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 48/147 (32%), Positives = 59/147 (40%), Gaps = 44/147 (29%)

Query: 198 PIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPA 257
           P+ A   A   V  L P P    A  PA AP+PV APAP P PAP PAP      APAPA
Sbjct: 164 PVAAPVAAPVAVAVLAPAPAP--APAPAPAPAPVAAPAPAPAPAPAPAP------APAPA 215

Query: 258 PEL--QQAPE------------------------PAVGLESAPAPALELEP--------- 282
           P+   Q++ E                        PA G  +A A    ++          
Sbjct: 216 PDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKLSGPLISDF 275

Query: 283 -APEQDPAPSQTLELEPAPAPVPSLQP 308
            A  +  AP ++    PAP P PS  P
Sbjct: 276 FAKRKRSAPEKSSGDVPAPCPSPSAAP 302



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 39/99 (39%), Positives = 44/99 (44%), Gaps = 15/99 (15%)

Query: 227 APSPVP---APAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPA 283
           AP PV    A +P  EPA     G  LE AP   P +   P PA      P P L   PA
Sbjct: 105 APRPVAVAVAVSPPLEPAAESLDG--LEEAPEQLPSV---PVPAPASTPPPVPVLAPAPA 159

Query: 284 PEQDP------APSQTLELEPAPAPVPSLQPSWPSPVVA 316
           P   P      AP     L PAPAP P+  P+ P+PV A
Sbjct: 160 PAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPA-PAPVAA 197


>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
          Length = 1499

 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 49/166 (29%), Positives = 82/166 (49%), Gaps = 14/166 (8%)

Query: 316 AENGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTI 375
           A+  L E +  LL      VA Q ++ + ELF+ + P   +  ++  R K        T 
Sbjct: 702 AQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSK--------TS 753

Query: 376 RATVTQFNSVAN----CVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAIL 431
            A + +F  V N     V +  L  R T    R ++++H+I++A  CR  KNF+S++AI+
Sbjct: 754 CANLKRFEEVINQETFWVASEIL--RETNQLKRMKIIKHFIKIALHCRECKNFNSMFAII 811

Query: 432 SALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELL 477
           S L    + RL+ TWE +     ++FQ L ++F    N +  R +L
Sbjct: 812 SGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVL 857



 Score = 30.8 bits (68), Expect = 5.6
 Identities = 17/44 (38%), Positives = 23/44 (52%)

Query: 55  TCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTT 98
           T K   V  GT E+L  HLV      D +++  FL TYR F ++
Sbjct: 265 TRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSS 308


>gi|213385270 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 71/314 (22%), Positives = 128/314 (40%), Gaps = 54/314 (17%)

Query: 310 WPSPVVAENGLSEEKPHLLVFP---PDLVAEQFTLMDAELFKKV--------VPYHCLGS 358
           W   V     +S++    L+F    P  +AE  T ++ + F+++        V + CL +
Sbjct: 128 WMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLEN 187

Query: 359 IWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVAREC 418
                         PT+  ++  FN ++  V    L   + +   RA V+  +I VA++ 
Sbjct: 188 -------------NPTLERSIALFNGISKWVQLMVLSKPTPQ--QRAEVITKFINVAKKL 232

Query: 419 RILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLI 478
             LKNF++L A++  L  +SI RLK+T   +S +  + + +++E+ S   NY   R+   
Sbjct: 233 LQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFA 292

Query: 479 KEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFE 538
                K                        +P LG  L DL+ +     D+     +N  
Sbjct: 293 DCDGFK------------------------IPILGVHLKDLIAVHVIFPDWTEENKVNIV 328

Query: 539 KRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETES--YNLSCELEPPSES 596
           K  +    ++++  LQ+A  ++ + P+            L  TE   Y LS  LEP +  
Sbjct: 329 KMHQLSVTLSELVSLQNA--SHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386

Query: 597 ASNTLRTKKNTAIV 610
           +  T  T  N  +V
Sbjct: 387 SQPTSPTTPNKPVV 400


>gi|24762239 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 1 [Homo sapiens]
          Length = 690

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 71/314 (22%), Positives = 128/314 (40%), Gaps = 54/314 (17%)

Query: 310 WPSPVVAENGLSEEKPHLLVFP---PDLVAEQFTLMDAELFKKV--------VPYHCLGS 358
           W   V     +S++    L+F    P  +AE  T ++ + F+++        V + CL +
Sbjct: 128 WMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLEN 187

Query: 359 IWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVAREC 418
                         PT+  ++  FN ++  V    L   + +   RA V+  +I VA++ 
Sbjct: 188 -------------NPTLERSIALFNGISKWVQLMVLSKPTPQ--QRAEVITKFINVAKKL 232

Query: 419 RILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLI 478
             LKNF++L A++  L  +SI RLK+T   +S +  + + +++E+ S   NY   R+   
Sbjct: 233 LQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFA 292

Query: 479 KEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFE 538
                K                        +P LG  L DL+ +     D+     +N  
Sbjct: 293 DCDGFK------------------------IPILGVHLKDLIAVHVIFPDWTEENKVNIV 328

Query: 539 KRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETES--YNLSCELEPPSES 596
           K  +    ++++  LQ+A  ++ + P+            L  TE   Y LS  LEP +  
Sbjct: 329 KMHQLSVTLSELVSLQNA--SHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386

Query: 597 ASNTLRTKKNTAIV 610
           +  T  T  N  +V
Sbjct: 387 SQPTSPTTPNKPVV 400


>gi|7662334 RAS guanyl releasing protein 3 (calcium and
           DAG-regulated) isoform 2 [Homo sapiens]
          Length = 689

 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 69/318 (21%), Positives = 128/318 (40%), Gaps = 54/318 (16%)

Query: 310 WPSPVVAENGLSEEKPHLLVFP---PDLVAEQFTLMDAELFKKV--------VPYHCLGS 358
           W   V     +S++    L+F    P  +AE  T ++ + F+++        V + CL +
Sbjct: 128 WMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLEN 187

Query: 359 IWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVAREC 418
                         PT+  ++  FN ++  V    L   + +   RA V+  +I VA++ 
Sbjct: 188 -------------NPTLERSIALFNGISKWVQLMVLSKPTPQ--QRAEVITKFINVAKKL 232

Query: 419 RILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLI 478
             LKNF++L A++  L  +SI RLK+T   +S +  + + +++E+ S   NY   R+   
Sbjct: 233 LQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFA 292

Query: 479 KEGTSKFATLEMNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFE 538
                K                        +P LG  L DL+ +     D+     +N  
Sbjct: 293 DCDGFK------------------------IPILGVHLKDLIAVHVIFPDWTEENKVNIV 328

Query: 539 KRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVERLSETES--YNLSCELEPPSES 596
           K  +    ++++  LQ+A  ++ + P+            L  TE   Y LS  LEP +  
Sbjct: 329 KMHQLSVTLSELVSLQNA--SHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386

Query: 597 ASNTLRTKKNTAIVKRWS 614
           +  +  T     +   W+
Sbjct: 387 SPTSPTTPNKPVVPLEWA 404


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,026,900
Number of Sequences: 37866
Number of extensions: 2152317
Number of successful extensions: 39208
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 635
Number of HSP's successfully gapped in prelim test: 1260
Number of HSP's that attempted gapping in prelim test: 14474
Number of HSP's gapped (non-prelim): 11493
length of query: 859
length of database: 18,247,518
effective HSP length: 111
effective length of query: 748
effective length of database: 14,044,392
effective search space: 10505205216
effective search space used: 10505205216
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.