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Search of human proteins with 4557671
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557671 proinsulin precursor [Homo sapiens]
(110 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557671 proinsulin precursor [Homo sapiens] 231 9e-62
gi|109148522 insulin- insulin-like growth factor 2 [Homo sapiens] 134 2e-32
gi|4504609 insulin-like growth factor 2 isoform 1 precursor [Hom... 52 8e-08
gi|108796063 insulin-like growth factor 2 isoform 1 precursor [H... 52 8e-08
gi|189083846 insulin-like growth factor 2 isoform 2 [Homo sapiens] 52 8e-08
gi|11024682 insulin-like growth factor 1 isoform 4 preproprotein... 49 7e-07
gi|163659903 insulin-like growth factor 1 isoform 3 preproprotei... 49 7e-07
gi|163659901 insulin-like growth factor 1 isoform 2 preproprotei... 49 7e-07
gi|163659899 insulin-like growth factor 1 isoform 1 preproprotei... 49 7e-07
gi|38327535 insulin-like 3 precursor [Homo sapiens] 32 0.084
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 30 0.42
gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo sap... 30 0.42
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 29 0.93
gi|197927448 WD repeat domain 6 protein [Homo sapiens] 28 2.1
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso... 28 2.1
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs... 28 2.1
gi|73747879 rabconnectin-3 beta isoform 2 [Homo sapiens] 27 2.7
gi|73747877 rabconnectin-3 beta isoform 1 [Homo sapiens] 27 2.7
gi|25092658 hypothetical protein LOC221927 [Homo sapiens] 27 2.7
gi|18254464 relaxin 3 preproprotein [Homo sapiens] 27 3.5
gi|109150431 ring finger protein 31 [Homo sapiens] 26 6.0
gi|194272180 plexin B1 [Homo sapiens] 26 7.8
gi|40254442 plexin B1 [Homo sapiens] 26 7.8
>gi|4557671 proinsulin precursor [Homo sapiens]
Length = 110
Score = 231 bits (589), Expect = 9e-62
Identities = 110/110 (100%), Positives = 110/110 (100%)
Query: 1 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED 60
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
Sbjct: 1 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED 60
Query: 61 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN 110
LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
Sbjct: 61 LQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN 110
>gi|109148522 insulin- insulin-like growth factor 2 [Homo sapiens]
Length = 200
Score = 134 bits (337), Expect = 2e-32
Identities = 63/68 (92%), Positives = 64/68 (94%)
Query: 1 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED 60
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED
Sbjct: 1 MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAED 60
Query: 61 LQVGQVEL 68
LQ + L
Sbjct: 61 LQASALSL 68
>gi|4504609 insulin-like growth factor 2 isoform 1 precursor [Homo
sapiens]
Length = 180
Score = 52.4 bits (124), Expect = 8e-08
Identities = 34/103 (33%), Positives = 44/103 (42%), Gaps = 27/103 (26%)
Query: 7 LLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQV 66
+L LL LA AA ++ LCG LV+ L VCG+RGF+++ R
Sbjct: 9 MLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRV--------- 59
Query: 67 ELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYC 109
S + RGIVE+CC C L LE YC
Sbjct: 60 ------------------SRRSRGIVEECCFRSCDLALLETYC 84
>gi|108796063 insulin-like growth factor 2 isoform 1 precursor [Homo
sapiens]
Length = 180
Score = 52.4 bits (124), Expect = 8e-08
Identities = 34/103 (33%), Positives = 44/103 (42%), Gaps = 27/103 (26%)
Query: 7 LLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQV 66
+L LL LA AA ++ LCG LV+ L VCG+RGF+++ R
Sbjct: 9 MLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRV--------- 59
Query: 67 ELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYC 109
S + RGIVE+CC C L LE YC
Sbjct: 60 ------------------SRRSRGIVEECCFRSCDLALLETYC 84
>gi|189083846 insulin-like growth factor 2 isoform 2 [Homo sapiens]
Length = 236
Score = 52.4 bits (124), Expect = 8e-08
Identities = 34/103 (33%), Positives = 44/103 (42%), Gaps = 27/103 (26%)
Query: 7 LLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQV 66
+L LL LA AA ++ LCG LV+ L VCG+RGF+++ R
Sbjct: 65 MLVLLTFLAFASCCIAAYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRV--------- 115
Query: 67 ELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYC 109
S + RGIVE+CC C L LE YC
Sbjct: 116 ------------------SRRSRGIVEECCFRSCDLALLETYC 140
>gi|11024682 insulin-like growth factor 1 isoform 4 preproprotein
[Homo sapiens]
Length = 153
Score = 49.3 bits (116), Expect = 7e-07
Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 23/80 (28%)
Query: 30 LCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKR 89
LCG+ LV+AL VCG+RGF++ T G G+ S + +
Sbjct: 53 LCGAELVDALQFVCGDRGFYFNKPT----------------GYGSSSRR-------APQT 89
Query: 90 GIVEQCCTSICSLYQLENYC 109
GIV++CC C L +LE YC
Sbjct: 90 GIVDECCFRSCDLRRLEMYC 109
>gi|163659903 insulin-like growth factor 1 isoform 3 preproprotein
[Homo sapiens]
Length = 195
Score = 49.3 bits (116), Expect = 7e-07
Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 23/80 (28%)
Query: 30 LCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKR 89
LCG+ LV+AL VCG+RGF++ T G G+ S + +
Sbjct: 53 LCGAELVDALQFVCGDRGFYFNKPT----------------GYGSSSRR-------APQT 89
Query: 90 GIVEQCCTSICSLYQLENYC 109
GIV++CC C L +LE YC
Sbjct: 90 GIVDECCFRSCDLRRLEMYC 109
>gi|163659901 insulin-like growth factor 1 isoform 2 preproprotein
[Homo sapiens]
Length = 137
Score = 49.3 bits (116), Expect = 7e-07
Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 23/80 (28%)
Query: 30 LCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKR 89
LCG+ LV+AL VCG+RGF++ T G G+ S + +
Sbjct: 37 LCGAELVDALQFVCGDRGFYFNKPT----------------GYGSSSRR-------APQT 73
Query: 90 GIVEQCCTSICSLYQLENYC 109
GIV++CC C L +LE YC
Sbjct: 74 GIVDECCFRSCDLRRLEMYC 93
>gi|163659899 insulin-like growth factor 1 isoform 1 preproprotein
[Homo sapiens]
Length = 158
Score = 49.3 bits (116), Expect = 7e-07
Identities = 28/80 (35%), Positives = 39/80 (48%), Gaps = 23/80 (28%)
Query: 30 LCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKR 89
LCG+ LV+AL VCG+RGF++ T G G+ S + +
Sbjct: 53 LCGAELVDALQFVCGDRGFYFNKPT----------------GYGSSSRR-------APQT 89
Query: 90 GIVEQCCTSICSLYQLENYC 109
GIV++CC C L +LE YC
Sbjct: 90 GIVDECCFRSCDLRRLEMYC 109
>gi|38327535 insulin-like 3 precursor [Homo sapiens]
Length = 131
Score = 32.3 bits (72), Expect = 0.084
Identities = 39/128 (30%), Positives = 48/128 (37%), Gaps = 28/128 (21%)
Query: 4 WMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREA----- 58
W +L AL+ GP P + + LCG H V AL VCG G ++ + RR A
Sbjct: 8 WALVLLGPALVFALGPAPTPE-MREKLCGHHFVRALVRVCG--GPRWSTEARRPATGGDR 64
Query: 59 EDLQ-----------VGQVELGGGPGAGSLQPLALEGSLQKR------GIVEQCCTSICS 101
E LQ V L GPG LQPL + CC S C+
Sbjct: 65 ELLQWLERRHLLHGLVADSNLTLGPG---LQPLPQTSHHHRHHRAAATNPARYCCLSGCT 121
Query: 102 LYQLENYC 109
L C
Sbjct: 122 QQDLLTLC 129
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 30.0 bits (66), Expect = 0.42
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 6/69 (8%)
Query: 11 LALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFF--YTPKTRREAEDLQVGQVEL 68
++LL+ W + F HLCG ++ L+++ + Y PK + +QVG V L
Sbjct: 222 MSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPK----SWTIQVGLVSL 277
Query: 69 GGGPGAGSL 77
P L
Sbjct: 278 LDNPAPSHL 286
>gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo
sapiens]
Length = 344
Score = 30.0 bits (66), Expect = 0.42
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 6/69 (8%)
Query: 11 LALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFF--YTPKTRREAEDLQVGQVEL 68
++LL+ W + F HLCG ++ L+++ + Y PK + +QVG V L
Sbjct: 222 MSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPK----SWTIQVGLVSL 277
Query: 69 GGGPGAGSL 77
P L
Sbjct: 278 LDNPAPSHL 286
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 28.9 bits (63), Expect = 0.93
Identities = 18/75 (24%), Positives = 32/75 (42%)
Query: 11 LALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGG 70
LA + W + F H+CG L++A +++ FF T + E + G L
Sbjct: 331 LASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQ 390
Query: 71 GPGAGSLQPLALEGS 85
P A S+ + + +
Sbjct: 391 LPEAASIAEIIINSN 405
>gi|197927448 WD repeat domain 6 protein [Homo sapiens]
Length = 1151
Score = 27.7 bits (60), Expect = 2.1
Identities = 25/84 (29%), Positives = 32/84 (38%), Gaps = 16/84 (19%)
Query: 29 HLCGSHLVEALYLVCGER-----------GFFYTP----KTRREAEDLQVGQVELGGGPG 73
H C + L +LVCG+R G P K R A VG GGG
Sbjct: 524 HTCSAFLPPGDFLVCGDRRGSVLLFPSRPGLLKDPGVGGKARAGAGAPVVGSGSSGGGNA 583
Query: 74 AGSLQPLALEGSLQ-KRGIVEQCC 96
L P++ SL K+G+ C
Sbjct: 584 FTGLGPVSTLPSLHGKQGVTSVTC 607
>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
[Homo sapiens]
Length = 1007
Score = 27.7 bits (60), Expect = 2.1
Identities = 13/21 (61%), Positives = 15/21 (71%)
Query: 4 WMRLLPLLALLALWGPDPAAA 24
W+ LLPLL LL L P PAA+
Sbjct: 22 WLLLLPLLLLLLLLLPGPAAS 42
>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 27.7 bits (60), Expect = 2.1
Identities = 13/21 (61%), Positives = 15/21 (71%)
Query: 4 WMRLLPLLALLALWGPDPAAA 24
W+ LLPLL LL L P PAA+
Sbjct: 22 WLLLLPLLLLLLLLLPGPAAS 42
>gi|73747879 rabconnectin-3 beta isoform 2 [Homo sapiens]
Length = 1457
Score = 27.3 bits (59), Expect = 2.7
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 82 LEGSLQKRGIVEQCCTSICSLYQLENY 108
LEGSL K+ +++C +IC Y + Y
Sbjct: 1303 LEGSLVKKKGLQECFPAICRFYMVSYY 1329
>gi|73747877 rabconnectin-3 beta isoform 1 [Homo sapiens]
Length = 1490
Score = 27.3 bits (59), Expect = 2.7
Identities = 11/27 (40%), Positives = 17/27 (62%)
Query: 82 LEGSLQKRGIVEQCCTSICSLYQLENY 108
LEGSL K+ +++C +IC Y + Y
Sbjct: 1336 LEGSLVKKKGLQECFPAICRFYMVSYY 1362
>gi|25092658 hypothetical protein LOC221927 [Homo sapiens]
Length = 821
Score = 27.3 bits (59), Expect = 2.7
Identities = 16/31 (51%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 2 ALWMRLLPLLALLALWGPDPAA-AFVNQHLC 31
ALW+RL P +A L P PAA +FV+ LC
Sbjct: 235 ALWVRLSPRVACLLERDPIPAAHSFVDLLLC 265
>gi|18254464 relaxin 3 preproprotein [Homo sapiens]
Length = 142
Score = 26.9 bits (58), Expect = 3.5
Identities = 15/43 (34%), Positives = 19/43 (44%), Gaps = 8/43 (18%)
Query: 10 LLALLALW--------GPDPAAAFVNQHLCGSHLVEALYLVCG 44
LL LLA+W G + AA LCG + A+ CG
Sbjct: 6 LLLLLAVWVLTGELWPGAEARAAPYGVRLCGREFIRAVIFTCG 48
>gi|109150431 ring finger protein 31 [Homo sapiens]
Length = 1072
Score = 26.2 bits (56), Expect = 6.0
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 4/39 (10%)
Query: 55 RREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVE 93
RR+ ++LQ LG GP GSLQ L G R + E
Sbjct: 577 RRKVQELQ----SLGFGPEEGSLQALFQHGGDVSRALTE 611
>gi|194272180 plexin B1 [Homo sapiens]
Length = 2135
Score = 25.8 bits (55), Expect = 7.8
Identities = 10/18 (55%), Positives = 12/18 (66%)
Query: 8 LPLLALLALWGPDPAAAF 25
+P + ALW PDP AAF
Sbjct: 181 IPPITTRALWPPDPQAAF 198
>gi|40254442 plexin B1 [Homo sapiens]
Length = 2135
Score = 25.8 bits (55), Expect = 7.8
Identities = 10/18 (55%), Positives = 12/18 (66%)
Query: 8 LPLLALLALWGPDPAAAF 25
+P + ALW PDP AAF
Sbjct: 181 IPPITTRALWPPDPQAAF 198
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.141 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 4,999,092
Number of Sequences: 37866
Number of extensions: 215512
Number of successful extensions: 627
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 601
Number of HSP's gapped (non-prelim): 26
length of query: 110
length of database: 18,247,518
effective HSP length: 80
effective length of query: 30
effective length of database: 15,218,238
effective search space: 456547140
effective search space used: 456547140
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 55 (25.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.