BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4557511 death-associated protein kinase 3 [Homo sapiens] (454 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4557511 death-associated protein kinase 3 [Homo sapiens] 890 0.0 gi|89363047 death-associated protein kinase 1 [Homo sapiens] 476 e-134 gi|14670383 death-associated kinase 2 [Homo sapiens] 454 e-128 gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] 259 4e-69 gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] 259 4e-69 gi|4758194 serine/threonine kinase 17B [Homo sapiens] 253 2e-67 gi|109255245 serine/threonine kinase 17a [Homo sapiens] 251 7e-67 gi|146219832 myosin light chain kinase 3 [Homo sapiens] 243 2e-64 gi|167466233 myosin light chain kinase family, member 4 [Homo sa... 240 2e-63 gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] 231 8e-61 gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] 231 8e-61 gi|14993776 skeletal myosin light chain kinase [Homo sapiens] 229 4e-60 gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 224 1e-58 gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 219 5e-57 gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 216 3e-56 gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 216 3e-56 gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 216 3e-56 gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 216 3e-56 gi|110349719 titin isoform N2-A [Homo sapiens] 212 5e-55 gi|110349717 titin isoform novex-2 [Homo sapiens] 212 5e-55 gi|110349713 titin isoform novex-1 [Homo sapiens] 212 5e-55 gi|110349715 titin isoform N2-B [Homo sapiens] 212 5e-55 gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 210 2e-54 gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 209 4e-54 gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 204 2e-52 gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 203 2e-52 gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 203 2e-52 gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 203 2e-52 gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 203 2e-52 gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 203 2e-52 >gi|4557511 death-associated protein kinase 3 [Homo sapiens] Length = 454 Score = 890 bits (2300), Expect = 0.0 Identities = 454/454 (100%), Positives = 454/454 (100%) Query: 1 MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE 60 MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE Sbjct: 1 MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE 60 Query: 61 IEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFL 120 IEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFL Sbjct: 61 IEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFL 120 Query: 121 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 180 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT Sbjct: 121 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 180 Query: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY 240 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY Sbjct: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY 240 Query: 241 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTT 300 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTT Sbjct: 241 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTT 300 Query: 301 RLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIY 360 RLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIY Sbjct: 301 RLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIY 360 Query: 361 EEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRY 420 EEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRY Sbjct: 361 EEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRY 420 Query: 421 EALAKQVASEMRFVQDLVRALEQEKLQGVECGLR 454 EALAKQVASEMRFVQDLVRALEQEKLQGVECGLR Sbjct: 421 EALAKQVASEMRFVQDLVRALEQEKLQGVECGLR 454 >gi|89363047 death-associated protein kinase 1 [Homo sapiens] Length = 1430 Score = 476 bits (1225), Expect = e-134 Identities = 227/276 (82%), Positives = 262/276 (94%) Query: 1 MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE 60 M+ FRQE+V+D+Y+ GEELGSGQFA+V+KCR+K TG +YAAKFIKKRR SSRRGVSRE+ Sbjct: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60 Query: 61 IEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFL 120 IEREV+IL+EI+HPN+ITLH+++ENKTDV+LILELV+GGELFDFLAEKESLTE+EAT+FL Sbjct: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFL 120 Query: 121 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 180 KQIL+GV+YLHS +IAHFDLKPENIMLLD+NVP PRIK+IDFG+AHKI+ GNEFKNIFGT Sbjct: 121 KQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGT 180 Query: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY 240 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLG+TKQETL N+SAVNY+F++EY Sbjct: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEY 240 Query: 241 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276 FSNTS LAKDFIRRLLVKDPK+RMTI SL+H WIK Sbjct: 241 FSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK 276 >gi|14670383 death-associated kinase 2 [Homo sapiens] Length = 370 Score = 454 bits (1168), Expect = e-128 Identities = 225/303 (74%), Positives = 265/303 (87%), Gaps = 7/303 (2%) Query: 1 MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE 60 M F+Q+ VED Y++GEELGSGQFAIV+KCR+K TG EYAAKFIKKR+ +SRRGVSREE Sbjct: 11 MEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREE 70 Query: 61 IEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFL 120 IEREV+ILR++ H N+ITLHD++EN+TDVVLILELVSGGELFDFLA+KESL+E+EAT F+ Sbjct: 71 IEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFI 130 Query: 121 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 180 KQILDGV+YLH+K+IAHFDLKPENIMLLDKN+P P IKLIDFG+AH+IE G EFKNIFGT Sbjct: 131 KQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 190 Query: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY 240 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLG+TKQETL NI+AV+YDFDEE+ Sbjct: 191 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF 250 Query: 241 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWI-------KAIRRRNVRGEDSGRKPE 293 FS TSELAKDFIR+LLVK+ ++R+TI ++L H WI +RR +V ++ RK Sbjct: 251 FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQQAMVRRESVVNLENFRKQY 310 Query: 294 RRR 296 RR Sbjct: 311 VRR 313 >gi|116008192 myosin light chain kinase isoform 1 [Homo sapiens] Length = 1914 Score = 259 bits (662), Expect = 4e-69 Identities = 131/301 (43%), Positives = 191/301 (63%), Gaps = 19/301 (6%) Query: 6 QEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 65 ++ V D Y++ E LGSG+F V + +K T K +A KF K + +E I +E+ Sbjct: 1457 EQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFK------AYSAKEKENIRQEI 1510 Query: 66 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKE-SLTEDEATQFLKQIL 124 +I+ + HP ++ D FE K ++V++LE+VSGGELF+ + +++ LTE E ++++QI Sbjct: 1511 SIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQIS 1570 Query: 125 DGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFV 184 +GV Y+H + I H DLKPENIM ++K RIKLIDFG+A ++E K +FGTPEFV Sbjct: 1571 EGVEYIHKQGIVHLDLKPENIMCVNKT--GTRIKLIDFGLARRLENAGSLKVLFGTPEFV 1628 Query: 185 APEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNT 244 APE++NYEP+G DMWSIGVI YIL+SG SPF+G+ ETL N+++ +DFD+E F Sbjct: 1629 APEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEI 1688 Query: 245 SELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTTRLKE 304 S+ AKDFI LL KD K R+ Q L+H W+ + E ++L R+K+ Sbjct: 1689 SDDAKDFISNLLKKDMKNRLDCTQCLQHPWLM----------KDTKNMEAKKLSKDRMKK 1738 Query: 305 Y 305 Y Sbjct: 1739 Y 1739 >gi|116008188 myosin light chain kinase isoform 2 [Homo sapiens] Length = 1845 Score = 259 bits (662), Expect = 4e-69 Identities = 131/301 (43%), Positives = 191/301 (63%), Gaps = 19/301 (6%) Query: 6 QEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 65 ++ V D Y++ E LGSG+F V + +K T K +A KF K + +E I +E+ Sbjct: 1388 EQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFK------AYSAKEKENIRQEI 1441 Query: 66 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKE-SLTEDEATQFLKQIL 124 +I+ + HP ++ D FE K ++V++LE+VSGGELF+ + +++ LTE E ++++QI Sbjct: 1442 SIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQIS 1501 Query: 125 DGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFV 184 +GV Y+H + I H DLKPENIM ++K RIKLIDFG+A ++E K +FGTPEFV Sbjct: 1502 EGVEYIHKQGIVHLDLKPENIMCVNKT--GTRIKLIDFGLARRLENAGSLKVLFGTPEFV 1559 Query: 185 APEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNT 244 APE++NYEP+G DMWSIGVI YIL+SG SPF+G+ ETL N+++ +DFD+E F Sbjct: 1560 APEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEI 1619 Query: 245 SELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTTRLKE 304 S+ AKDFI LL KD K R+ Q L+H W+ + E ++L R+K+ Sbjct: 1620 SDDAKDFISNLLKKDMKNRLDCTQCLQHPWLM----------KDTKNMEAKKLSKDRMKK 1669 Query: 305 Y 305 Y Sbjct: 1670 Y 1670 >gi|4758194 serine/threonine kinase 17B [Homo sapiens] Length = 372 Score = 253 bits (647), Expect = 2e-67 Identities = 129/276 (46%), Positives = 186/276 (67%), Gaps = 9/276 (3%) Query: 5 RQEDVEDHYEM-GEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIER 63 + E+ + Y + +ELG G+FA+VR+C K TG+EYAAKF+KKRR R EI Sbjct: 24 KMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQD----CRAEILH 79 Query: 64 EVNILREIRH-PNIITLHDIFENKTDVVLILELVSGGELFDFLAEK--ESLTEDEATQFL 120 E+ +L + P +I LH+++EN ++++LILE +GGE+F + E ++E++ + + Sbjct: 80 EIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLI 139 Query: 121 KQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGT 180 KQIL+GV+YLH I H DLKP+NI LL P IK++DFG++ KI E + I GT Sbjct: 140 KQILEGVYYLHQNNIVHLDLKPQNI-LLSSIYPLGDIKIVDFGMSRKIGHACELREIMGT 198 Query: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY 240 PE++APEI+NY+P+ DMW+IG+I Y+LL+ SPF+GE QET NIS VN D+ EE Sbjct: 199 PEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEET 258 Query: 241 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276 FS+ S+LA DFI+ LLVK+P++R T L HSW++ Sbjct: 259 FSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQ 294 >gi|109255245 serine/threonine kinase 17a [Homo sapiens] Length = 414 Score = 251 bits (642), Expect = 7e-67 Identities = 125/276 (45%), Positives = 187/276 (67%), Gaps = 10/276 (3%) Query: 5 RQEDVEDHYEM--GEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIE 62 R E +D Y + G ELG G+FA+VRKC +K +GKE+AAKF++KRR R EI Sbjct: 51 RTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQD----CRMEII 106 Query: 63 REVNILREIR-HPNIITLHDIFENKTDVVLILELVSGGELFDFLA--EKESLTEDEATQF 119 E+ +L + +P +I LH+++E ++++L+LE +GGE+FD +E+ E + + Sbjct: 107 HEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRL 166 Query: 120 LKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFG 179 ++QIL+GVH+LH++ + H DLKP+NI+L ++ P IK++DFG++ ++ E + I G Sbjct: 167 MRQILEGVHFLHTRDVVHLDLKPQNILLTSES-PLGDIKIVDFGLSRILKNSEELREIMG 225 Query: 180 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEE 239 TPE+VAPEI++Y+P+ + DMWSIGV+TY++L+G SPFLG KQET NIS +N + EE Sbjct: 226 TPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEE 285 Query: 240 YFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275 F SE A DFIR LLVK P+ R T + L+H W+ Sbjct: 286 EFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWL 321 >gi|146219832 myosin light chain kinase 3 [Homo sapiens] Length = 819 Score = 243 bits (621), Expect = 2e-64 Identities = 127/271 (46%), Positives = 172/271 (63%), Gaps = 9/271 (3%) Query: 17 EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNI 76 E LG G+F V +C +K TG AAK IK + RE+++ E+NI+ ++ H N+ Sbjct: 519 EVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKD------REDVKNEINIMNQLSHVNL 572 Query: 77 ITLHDIFENKTDVVLILELVSGGELFDFLA-EKESLTEDEATQFLKQILDGVHYLHSKRI 135 I L+D FE+K L++E V GGELFD + EK LTE + F +QI +GVHYLH I Sbjct: 573 IQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYI 632 Query: 136 AHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLG 195 H DLKPENI+ + N +IK+IDFG+A + + + K FGTPEF+APE+VNYE + Sbjct: 633 LHLDLKPENILCV--NQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVS 690 Query: 196 LEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRL 255 DMWS+GVITY+LLSG SPFLGET ET+ I ++DFD + F SE AKDF+ RL Sbjct: 691 FPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRL 750 Query: 256 LVKDPKRRMTIAQSLEHSWIKAIRRRNVRGE 286 LVK+ RM+ Q L+H W+ + + R + Sbjct: 751 LVKEKSCRMSATQCLKHEWLNNLPAKASRSK 781 >gi|167466233 myosin light chain kinase family, member 4 [Homo sapiens] Length = 388 Score = 240 bits (612), Expect = 2e-63 Identities = 120/276 (43%), Positives = 182/276 (65%), Gaps = 11/276 (3%) Query: 3 TFRQEDVEDHYEMG--EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREE 60 T +Q V Y + E LG G+F V KC + TG + AAK IK R + +EE Sbjct: 94 TAKQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKD------KEE 147 Query: 61 IEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFD-FLAEKESLTEDEATQF 119 ++ E++++ ++ H N+I L+D FE+K D+VL++E V GGELFD + E +LTE + F Sbjct: 148 VKNEISVMNQLDHANLIQLYDAFESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILF 207 Query: 120 LKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFG 179 +KQI +G+ ++H I H DLKPENI+ ++++ +IK+IDFG+A + + + K FG Sbjct: 208 MKQICEGIRHMHQMYILHLDLKPENILCVNRDAK--QIKIIDFGLARRYKPREKLKVNFG 265 Query: 180 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEE 239 TPEF+APE+VNY+ + DMWS+GVI Y+LLSG SPFLG+ ETL NI A +D ++E Sbjct: 266 TPEFLAPEVVNYDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDE 325 Query: 240 YFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275 F + SE AK+FI +LL+K+ R++ +++L+H W+ Sbjct: 326 EFQDISEEAKEFISKLLIKEKSWRISASEALKHPWL 361 >gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens] Length = 2986 Score = 231 bits (590), Expect = 8e-61 Identities = 111/271 (40%), Positives = 170/271 (62%), Gaps = 8/271 (2%) Query: 6 QEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 65 +E+ + Y E+G G+F+IV+KC K T K+ A KF+ K+ +E+ E Sbjct: 2677 KENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKK-------KEQAAHEA 2729 Query: 66 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILD 125 +L+ ++HP ITLHD +E+ T +LILEL+ G L D+L + L E++ +++ I++ Sbjct: 2730 ALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIME 2789 Query: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185 + YLH+ R+AH D+KPEN+ L+D +P PR+KLID A +I ++ G PEF A Sbjct: 2790 ALQYLHNCRVAHLDIKPENL-LIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAA 2848 Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245 PE++ P+ L D+WSIGV+TY++LSG SPFL E+K+ET N+ V++ F EYF S Sbjct: 2849 PEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVS 2908 Query: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276 A+DFI +L +D +RR T A L+H W++ Sbjct: 2909 NAARDFINVILQEDFRRRPTAATCLQHPWLQ 2939 >gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens] Length = 1289 Score = 231 bits (590), Expect = 8e-61 Identities = 111/271 (40%), Positives = 170/271 (62%), Gaps = 8/271 (2%) Query: 6 QEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 65 +E+ + Y E+G G+F+IV+KC K T K+ A KF+ K+ +E+ E Sbjct: 980 KENFDSAYTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKK-------KEQAAHEA 1032 Query: 66 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILD 125 +L+ ++HP ITLHD +E+ T +LILEL+ G L D+L + L E++ +++ I++ Sbjct: 1033 ALLQHLQHPQYITLHDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIME 1092 Query: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185 + YLH+ R+AH D+KPEN+ L+D +P PR+KLID A +I ++ G PEF A Sbjct: 1093 ALQYLHNCRVAHLDIKPENL-LIDLRIPVPRVKLIDLEDAVQISGHFHIHHLLGNPEFAA 1151 Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245 PE++ P+ L D+WSIGV+TY++LSG SPFL E+K+ET N+ V++ F EYF S Sbjct: 1152 PEVIQGIPVSLGTDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVS 1211 Query: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276 A+DFI +L +D +RR T A L+H W++ Sbjct: 1212 NAARDFINVILQEDFRRRPTAATCLQHPWLQ 1242 >gi|14993776 skeletal myosin light chain kinase [Homo sapiens] Length = 596 Score = 229 bits (584), Expect = 4e-60 Identities = 122/311 (39%), Positives = 183/311 (58%), Gaps = 18/311 (5%) Query: 1 MSTFRQEDVEDHYEMG--EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSR 58 M R +V + M E LG G+F V C +K TG + AAK IKK+ + Sbjct: 271 MVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKD------K 324 Query: 59 EEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKE-SLTEDEAT 117 E + E+ ++ ++ H N+I L+ E ++VL +E + GGELF+ + +++ LTE + Sbjct: 325 EMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFMEYIEGGELFERIVDEDYHLTEVDTM 384 Query: 118 QFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNI 177 F++QI DG+ ++H R+ H DLKPENI+ + N +K+IDFG+A + + K Sbjct: 385 VFVRQICDGILFMHKMRVLHLDLKPENILCV--NTTGHLVKIIDFGLARRYNPNEKLKVN 442 Query: 178 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFD 237 FGTPEF++PE+VNY+ + + DMWS+GVITY+LLSG SPFLG+ ETL N+ + N+ FD Sbjct: 443 FGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFD 502 Query: 238 EEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRL 297 EE F S+ AKDF+ L+VKD + RM AQ L H W+ + + ++ RR Sbjct: 503 EETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNL-------AEKAKRCNRRLK 555 Query: 298 KTTRLKEYTIK 308 LK+Y +K Sbjct: 556 SQILLKKYLMK 566 >gi|45439359 triple functional domain (PTPRF interacting) [Homo sapiens] Length = 3097 Score = 224 bits (572), Expect = 1e-58 Identities = 113/285 (39%), Positives = 176/285 (61%), Gaps = 8/285 (2%) Query: 6 QEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 65 +++ + Y ELG G+F++V+KC QKGT + A KF+ K+ + R+++ E+ Sbjct: 2789 KDNFDSFYSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMK-------RDQVTHEL 2841 Query: 66 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILD 125 IL+ ++HP ++ L D FE T +L+LE+ G L D + SLTE + L ++L+ Sbjct: 2842 GILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLE 2901 Query: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185 V YLH+ RIAH DLKPENI L+D+++ P IKL DFG A ++ + G PEF A Sbjct: 2902 AVRYLHNCRIAHLDLKPENI-LVDESLAKPTIKLADFGDAVQLNTTYYIHQLLGNPEFAA 2960 Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245 PEI+ P+ L +D WS+GV+TY+LLSG SPFL ++ +ET NI +++ F ++YF S Sbjct: 2961 PEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVS 3020 Query: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGR 290 + AK+F+ LL +DP +R + A +L+ W++A R+ D+ R Sbjct: 3021 QKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTGVLDTSR 3065 >gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo sapiens] Length = 473 Score = 219 bits (557), Expect = 5e-57 Identities = 148/451 (32%), Positives = 229/451 (50%), Gaps = 50/451 (11%) Query: 6 QEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 65 ++ + D +E+ ELG G +IV +C+QKGT K YA K +KK V ++ + E+ Sbjct: 39 RDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT--------VDKKIVRTEI 90 Query: 66 NILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILD 125 +L + HPNII L +IFE T++ L+LELV+GGELFD + EK +E +A +KQIL+ Sbjct: 91 GVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILE 150 Query: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185 V YLH I H DLKPEN +L P+ +K+ DFG++ +E K + GTP + A Sbjct: 151 AVAYLHENGIVHRDLKPEN-LLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCA 209 Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGET-KQETLTNISAVNYDFDEEYFSNT 244 PEI+ G E DMWS+G+ITYILL G PF E Q I Y F ++ Sbjct: 210 PEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEV 269 Query: 245 SELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPE----RRRLKTT 300 S AKD +R+L+V DPK+R+T Q+L+H W+ V + + +K + RR+LK Sbjct: 270 SLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAA 329 Query: 301 RLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIY 360 + + S ++S+ + K + + ++G +ED++A+ Sbjct: 330 --VKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDG-----------NEDMKAI---- 372 Query: 361 EEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRY 420 E + + D + + + E +K QA E+ KGA + E Sbjct: 373 --------PEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINA----------EEAP 414 Query: 421 EALAKQVASEMRFVQ-DLVRALEQEKLQGVE 450 + + K V ++ +L L +EKL+ VE Sbjct: 415 KMVPKAVEDGIKVADLELEEGLAEEKLKTVE 445 >gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1 [Homo sapiens] Length = 357 Score = 216 bits (550), Expect = 3e-56 Identities = 111/269 (41%), Positives = 159/269 (59%), Gaps = 6/269 (2%) Query: 7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 66 ED++ +E E LG+G F+ V +K TGK +A K I K+ L IE E+ Sbjct: 17 EDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-----SSIENEIA 71 Query: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 126 +LR+I+H NI+ L DI+E+ + L+++LVSGGELFD + EK TE +A+ ++Q+LD Sbjct: 72 VLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDA 131 Query: 127 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 186 V+YLH I H DLKPEN++ ++ + +I + DFG++ G+ GTP +VAP Sbjct: 132 VYYLHRMGIVHRDLKPENLLYYSQDEES-KIMISDFGLSKMEGKGDVMSTACGTPGYVAP 190 Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSE 246 E++ +P D WSIGVI YILL G PF E + I Y+FD Y+ + S+ Sbjct: 191 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISD 250 Query: 247 LAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275 AKDFIR L+ KDP +R T Q+ H WI Sbjct: 251 SAKDFIRNLMEKDPNKRYTCEQAARHPWI 279 >gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform 2 [Homo sapiens] Length = 385 Score = 216 bits (550), Expect = 3e-56 Identities = 111/269 (41%), Positives = 159/269 (59%), Gaps = 6/269 (2%) Query: 7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 66 ED++ +E E LG+G F+ V +K TGK +A K I K+ L IE E+ Sbjct: 17 EDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-----SSIENEIA 71 Query: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 126 +LR+I+H NI+ L DI+E+ + L+++LVSGGELFD + EK TE +A+ ++Q+LD Sbjct: 72 VLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDA 131 Query: 127 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 186 V+YLH I H DLKPEN++ ++ + +I + DFG++ G+ GTP +VAP Sbjct: 132 VYYLHRMGIVHRDLKPENLLYYSQDEES-KIMISDFGLSKMEGKGDVMSTACGTPGYVAP 190 Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSE 246 E++ +P D WSIGVI YILL G PF E + I Y+FD Y+ + S+ Sbjct: 191 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISD 250 Query: 247 LAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275 AKDFIR L+ KDP +R T Q+ H WI Sbjct: 251 SAKDFIRNLMEKDPNKRYTCEQAARHPWI 279 >gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM kinase isoform b [Homo sapiens] Length = 360 Score = 216 bits (550), Expect = 3e-56 Identities = 116/269 (43%), Positives = 167/269 (62%), Gaps = 7/269 (2%) Query: 7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 66 ED+ YE+ E LGSG F+ V +++G+ A K I K+ L RG +E E+ Sbjct: 26 EDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL----RG-KEALVENEIA 80 Query: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 126 +LR I HPNI+ L D+ E+ + + L +ELV+GGELFD + E+ S TE +A+ + Q+L Sbjct: 81 VLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGA 140 Query: 127 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 186 V YLHS I H DLKPEN++ + +I + DFG++ KI+AGN GTP +VAP Sbjct: 141 VSYLHSLGIVHRDLKPENLLYATP-FEDSKIMVSDFGLS-KIQAGNMLGTACGTPGYVAP 198 Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSE 246 E++ +P G D+W++GVI+YILL G PF E+ E + I +Y+FD ++ + SE Sbjct: 199 ELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 258 Query: 247 LAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275 AKDFIR LL +DP++R T Q+L H WI Sbjct: 259 SAKDFIRHLLERDPQKRFTCQQALRHLWI 287 >gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM kinase isoform a [Homo sapiens] Length = 426 Score = 216 bits (550), Expect = 3e-56 Identities = 116/269 (43%), Positives = 167/269 (62%), Gaps = 7/269 (2%) Query: 7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 66 ED+ YE+ E LGSG F+ V +++G+ A K I K+ L RG +E E+ Sbjct: 92 EDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKAL----RG-KEALVENEIA 146 Query: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 126 +LR I HPNI+ L D+ E+ + + L +ELV+GGELFD + E+ S TE +A+ + Q+L Sbjct: 147 VLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGA 206 Query: 127 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 186 V YLHS I H DLKPEN++ + +I + DFG++ KI+AGN GTP +VAP Sbjct: 207 VSYLHSLGIVHRDLKPENLLYATP-FEDSKIMVSDFGLS-KIQAGNMLGTACGTPGYVAP 264 Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSE 246 E++ +P G D+W++GVI+YILL G PF E+ E + I +Y+FD ++ + SE Sbjct: 265 ELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISE 324 Query: 247 LAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275 AKDFIR LL +DP++R T Q+L H WI Sbjct: 325 SAKDFIRHLLERDPQKRFTCQQALRHLWI 353 >gi|110349719 titin isoform N2-A [Homo sapiens] Length = 33423 Score = 212 bits (540), Expect = 5e-55 Identities = 103/271 (38%), Positives = 169/271 (62%), Gaps = 10/271 (3%) Query: 7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 66 +++ + Y + E+LG G+F IV +C + + K Y AKF+K + G + +++E++ Sbjct: 31245 KELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK-------GTDQVLVKKEIS 31297 Query: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKE-SLTEDEATQFLKQILD 125 IL RH NI+ LH+ FE+ ++V+I E +SG ++F+ + L E E ++ Q+ + Sbjct: 31298 ILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCE 31357 Query: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185 + +LHS I HFD++PENI+ + + IK+I+FG A +++ G+ F+ +F PE+ A Sbjct: 31358 ALQFLHSHNIGHFDIRPENIIYQTRR--SSTIKIIEFGQARQLKPGDNFRLLFTAPEYYA 31415 Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245 PE+ ++ + DMWS+G + Y+LLSG +PFL ET Q+ + NI Y FDEE F S Sbjct: 31416 PEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEIS 31475 Query: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276 A DF+ RLLVK+ K RMT +++L+H W+K Sbjct: 31476 IEAMDFVDRLLVKERKSRMTASEALQHPWLK 31506 >gi|110349717 titin isoform novex-2 [Homo sapiens] Length = 27118 Score = 212 bits (540), Expect = 5e-55 Identities = 103/271 (38%), Positives = 169/271 (62%), Gaps = 10/271 (3%) Query: 7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 66 +++ + Y + E+LG G+F IV +C + + K Y AKF+K + G + +++E++ Sbjct: 24940 KELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK-------GTDQVLVKKEIS 24992 Query: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKE-SLTEDEATQFLKQILD 125 IL RH NI+ LH+ FE+ ++V+I E +SG ++F+ + L E E ++ Q+ + Sbjct: 24993 ILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCE 25052 Query: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185 + +LHS I HFD++PENI+ + + IK+I+FG A +++ G+ F+ +F PE+ A Sbjct: 25053 ALQFLHSHNIGHFDIRPENIIYQTRR--SSTIKIIEFGQARQLKPGDNFRLLFTAPEYYA 25110 Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245 PE+ ++ + DMWS+G + Y+LLSG +PFL ET Q+ + NI Y FDEE F S Sbjct: 25111 PEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEIS 25170 Query: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276 A DF+ RLLVK+ K RMT +++L+H W+K Sbjct: 25171 IEAMDFVDRLLVKERKSRMTASEALQHPWLK 25201 >gi|110349713 titin isoform novex-1 [Homo sapiens] Length = 27051 Score = 212 bits (540), Expect = 5e-55 Identities = 103/271 (38%), Positives = 169/271 (62%), Gaps = 10/271 (3%) Query: 7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 66 +++ + Y + E+LG G+F IV +C + + K Y AKF+K + G + +++E++ Sbjct: 24873 KELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK-------GTDQVLVKKEIS 24925 Query: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKE-SLTEDEATQFLKQILD 125 IL RH NI+ LH+ FE+ ++V+I E +SG ++F+ + L E E ++ Q+ + Sbjct: 24926 ILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCE 24985 Query: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185 + +LHS I HFD++PENI+ + + IK+I+FG A +++ G+ F+ +F PE+ A Sbjct: 24986 ALQFLHSHNIGHFDIRPENIIYQTRR--SSTIKIIEFGQARQLKPGDNFRLLFTAPEYYA 25043 Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245 PE+ ++ + DMWS+G + Y+LLSG +PFL ET Q+ + NI Y FDEE F S Sbjct: 25044 PEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEIS 25103 Query: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276 A DF+ RLLVK+ K RMT +++L+H W+K Sbjct: 25104 IEAMDFVDRLLVKERKSRMTASEALQHPWLK 25134 >gi|110349715 titin isoform N2-B [Homo sapiens] Length = 26926 Score = 212 bits (540), Expect = 5e-55 Identities = 103/271 (38%), Positives = 169/271 (62%), Gaps = 10/271 (3%) Query: 7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 66 +++ + Y + E+LG G+F IV +C + + K Y AKF+K + G + +++E++ Sbjct: 24748 KELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK-------GTDQVLVKKEIS 24800 Query: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKE-SLTEDEATQFLKQILD 125 IL RH NI+ LH+ FE+ ++V+I E +SG ++F+ + L E E ++ Q+ + Sbjct: 24801 ILNIARHRNILHLHESFESMEELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCE 24860 Query: 126 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 185 + +LHS I HFD++PENI+ + + IK+I+FG A +++ G+ F+ +F PE+ A Sbjct: 24861 ALQFLHSHNIGHFDIRPENIIYQTRR--SSTIKIIEFGQARQLKPGDNFRLLFTAPEYYA 24918 Query: 186 PEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTS 245 PE+ ++ + DMWS+G + Y+LLSG +PFL ET Q+ + NI Y FDEE F S Sbjct: 24919 PEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKEIS 24978 Query: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK 276 A DF+ RLLVK+ K RMT +++L+H W+K Sbjct: 24979 IEAMDFVDRLLVKERKSRMTASEALQHPWLK 25009 >gi|149589021 doublecortin-like kinase 3 [Homo sapiens] Length = 648 Score = 210 bits (535), Expect = 2e-54 Identities = 110/277 (39%), Positives = 163/277 (58%), Gaps = 9/277 (3%) Query: 8 DVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNI 67 +VE HYE G +G G FA+V++CR + T + YA K I K RL + ++ E+ I Sbjct: 351 NVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKE-----DMVDSEILI 405 Query: 68 LREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGV 127 ++ + HPNI+ LH+++E ++ LILE V GG+LFD + E E +A + + + Sbjct: 406 IQSLSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKAL 465 Query: 128 HYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPE 187 ++H K I H DLKPEN+++ + +KL DFG+A + + GTP +VAPE Sbjct: 466 VHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVV--RPIFTVCGTPTYVAPE 523 Query: 188 IVNYEPLGLEADMWSIGVITYILLSGASPFLG-ETKQETLTNISAV-NYDFDEEYFSNTS 245 I++ + GLE DMW+ GVI YILL G PF E Q+ L NI + +++F Y+ N S Sbjct: 524 ILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNIS 583 Query: 246 ELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRN 282 + AKD + RLLV DPK+R T Q L+H WI+ + N Sbjct: 584 DAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTN 620 >gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo sapiens] Length = 370 Score = 209 bits (532), Expect = 4e-54 Identities = 111/269 (41%), Positives = 157/269 (58%), Gaps = 6/269 (2%) Query: 7 EDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVN 66 ED+ D Y+ + LG+G F+ V K T K A K I K L + E E+ Sbjct: 14 EDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSM-----ENEIA 68 Query: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 126 +L +I+HPNI+ L DI+E+ + LI++LVSGGELFD + EK TE +A++ + Q+LD Sbjct: 69 VLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDA 128 Query: 127 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAP 186 V YLH I H DLKPEN++ + + +I + DFG++ + G+ GTP +VAP Sbjct: 129 VKYLHDLGIVHRDLKPENLLYYSLD-EDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAP 187 Query: 187 EIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSE 246 E++ +P D WSIGVI YILL G PF E + I Y+FD Y+ + S+ Sbjct: 188 EVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISD 247 Query: 247 LAKDFIRRLLVKDPKRRMTIAQSLEHSWI 275 AKDFIR L+ KDP++R T Q+L+H WI Sbjct: 248 SAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo sapiens] Length = 476 Score = 204 bits (518), Expect = 2e-52 Identities = 114/259 (44%), Positives = 158/259 (61%), Gaps = 8/259 (3%) Query: 17 EELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNI 76 E LGSG F+ V +Q+ TGK +A K IKK S + R S +E E+ +L++I+H NI Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKK---SPAFRDSS---LENEIAVLKKIKHENI 80 Query: 77 ITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIA 136 +TL DI+E+ T L+++LVSGGELFD + E+ TE +A+ ++Q+L V YLH I Sbjct: 81 VTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIV 140 Query: 137 HFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGL 196 H DLKPEN++ L N +I + DFG++ K+E GTP +VAPE++ +P Sbjct: 141 HRDLKPENLLYLTPE-ENSKIMITDFGLS-KMEQNGIMSTACGTPGYVAPEVLAQKPYSK 198 Query: 197 EADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLL 256 D WSIGVITYILL G PF ET+ + I Y+F+ ++ + SE AKDFI LL Sbjct: 199 AVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHLL 258 Query: 257 VKDPKRRMTIAQSLEHSWI 275 KDP R T ++L H WI Sbjct: 259 EKDPNERYTCEKALSHPWI 277 >gi|212549756 calcium/calmodulin-dependent protein kinase II delta isoform 4 [Homo sapiens] Length = 489 Score = 203 bits (517), Expect = 2e-52 Identities = 103/266 (38%), Positives = 163/266 (61%), Gaps = 6/266 (2%) Query: 11 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 70 D Y++ EELG G F++VR+C + TG+EYAAK I ++LS+ +++ERE I R Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARICRL 67 Query: 71 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 130 ++HPNI+ LHD + L+ +LV+GGELF+ + +E +E +A+ ++QIL+ V++ Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127 Query: 131 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE-FKNIFGTPEFVAPEIV 189 H I H DLKPEN++L K+ +KL DFG+A +++ + + GTP +++PE++ Sbjct: 128 HLNGIVHRDLKPENLLLASKS-KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186 Query: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAK 249 +P G DMW+ GVI YILL G PF E + I A YDF + + AK Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246 Query: 250 DFIRRLLVKDPKRRMTIAQSLEHSWI 275 D I ++L +P +R+T +++L+H WI Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272 >gi|26667183 calcium/calmodulin-dependent protein kinase II delta isoform 1 [Homo sapiens] Length = 478 Score = 203 bits (517), Expect = 2e-52 Identities = 103/266 (38%), Positives = 163/266 (61%), Gaps = 6/266 (2%) Query: 11 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 70 D Y++ EELG G F++VR+C + TG+EYAAK I ++LS+ +++ERE I R Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARICRL 67 Query: 71 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 130 ++HPNI+ LHD + L+ +LV+GGELF+ + +E +E +A+ ++QIL+ V++ Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127 Query: 131 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE-FKNIFGTPEFVAPEIV 189 H I H DLKPEN++L K+ +KL DFG+A +++ + + GTP +++PE++ Sbjct: 128 HLNGIVHRDLKPENLLLASKS-KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186 Query: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAK 249 +P G DMW+ GVI YILL G PF E + I A YDF + + AK Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246 Query: 250 DFIRRLLVKDPKRRMTIAQSLEHSWI 275 D I ++L +P +R+T +++L+H WI Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272 >gi|212549753 calcium/calmodulin-dependent protein kinase II delta isoform 5 [Homo sapiens] Length = 492 Score = 203 bits (517), Expect = 2e-52 Identities = 103/266 (38%), Positives = 163/266 (61%), Gaps = 6/266 (2%) Query: 11 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 70 D Y++ EELG G F++VR+C + TG+EYAAK I ++LS+ +++ERE I R Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARICRL 67 Query: 71 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 130 ++HPNI+ LHD + L+ +LV+GGELF+ + +E +E +A+ ++QIL+ V++ Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127 Query: 131 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE-FKNIFGTPEFVAPEIV 189 H I H DLKPEN++L K+ +KL DFG+A +++ + + GTP +++PE++ Sbjct: 128 HLNGIVHRDLKPENLLLASKS-KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186 Query: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAK 249 +P G DMW+ GVI YILL G PF E + I A YDF + + AK Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246 Query: 250 DFIRRLLVKDPKRRMTIAQSLEHSWI 275 D I ++L +P +R+T +++L+H WI Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272 >gi|26667186 calcium/calmodulin-dependent protein kinase II delta isoform 1 [Homo sapiens] Length = 478 Score = 203 bits (517), Expect = 2e-52 Identities = 103/266 (38%), Positives = 163/266 (61%), Gaps = 6/266 (2%) Query: 11 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 70 D Y++ EELG G F++VR+C + TG+EYAAK I ++LS+ +++ERE I R Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARICRL 67 Query: 71 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 130 ++HPNI+ LHD + L+ +LV+GGELF+ + +E +E +A+ ++QIL+ V++ Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127 Query: 131 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE-FKNIFGTPEFVAPEIV 189 H I H DLKPEN++L K+ +KL DFG+A +++ + + GTP +++PE++ Sbjct: 128 HLNGIVHRDLKPENLLLASKS-KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186 Query: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAK 249 +P G DMW+ GVI YILL G PF E + I A YDF + + AK Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246 Query: 250 DFIRRLLVKDPKRRMTIAQSLEHSWI 275 D I ++L +P +R+T +++L+H WI Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272 >gi|26667189 calcium/calmodulin-dependent protein kinase II delta isoform 2 [Homo sapiens] Length = 478 Score = 203 bits (517), Expect = 2e-52 Identities = 103/266 (38%), Positives = 163/266 (61%), Gaps = 6/266 (2%) Query: 11 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 70 D Y++ EELG G F++VR+C + TG+EYAAK I ++LS+ +++ERE I R Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARICRL 67 Query: 71 IRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 130 ++HPNI+ LHD + L+ +LV+GGELF+ + +E +E +A+ ++QIL+ V++ Sbjct: 68 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 127 Query: 131 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNE-FKNIFGTPEFVAPEIV 189 H I H DLKPEN++L K+ +KL DFG+A +++ + + GTP +++PE++ Sbjct: 128 HLNGIVHRDLKPENLLLASKS-KGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL 186 Query: 190 NYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAK 249 +P G DMW+ GVI YILL G PF E + I A YDF + + AK Sbjct: 187 RKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAK 246 Query: 250 DFIRRLLVKDPKRRMTIAQSLEHSWI 275 D I ++L +P +R+T +++L+H WI Sbjct: 247 DLINKMLTINPAKRITASEALKHPWI 272 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.134 0.374 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,199,660 Number of Sequences: 37866 Number of extensions: 733950 Number of successful extensions: 6250 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 683 Number of HSP's successfully gapped in prelim test: 374 Number of HSP's that attempted gapping in prelim test: 3131 Number of HSP's gapped (non-prelim): 1771 length of query: 454 length of database: 18,247,518 effective HSP length: 106 effective length of query: 348 effective length of database: 14,233,722 effective search space: 4953335256 effective search space used: 4953335256 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.