Search of human proteins with 4557457

Search of human proteins with 4557457

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
precursor [Homo sapiens]
         (457 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   929   0.0  
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   915   0.0  
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   446   e-125
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   424   e-119
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    422   e-118
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   399   e-111
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   387   e-107
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   376   e-104
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   374   e-104
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     372   e-103
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   314   1e-85
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   313   2e-85
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   306   2e-83
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   298   5e-81
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   294   1e-79
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   261   7e-70
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   258   1e-68
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              225   7e-59
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   202   4e-52
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   201   1e-51
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   189   6e-48
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              174   2e-43
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   130   3e-30
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   128   9e-30
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   123   3e-28
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]        74   3e-13
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]          74   3e-13
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]        73   5e-13
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...    72   8e-13
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...    72   8e-13

>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  929 bits (2402), Expect = 0.0
 Identities = 457/457 (100%), Positives = 457/457 (100%)

Query: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60
           MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
Sbjct: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60

Query: 61  INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF 120
           INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF
Sbjct: 61  INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF 120

Query: 121 AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP 180
           AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP
Sbjct: 121 AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP 180

Query: 181 ESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVII 240
           ESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVII
Sbjct: 181 ESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVII 240

Query: 241 PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF 300
           PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF
Sbjct: 241 PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF 300

Query: 301 TMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKK 360
           TMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKK
Sbjct: 301 TMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKK 360

Query: 361 IFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWK 420
           IFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWK
Sbjct: 361 IFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWK 420

Query: 421 YVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG 457
           YVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG
Sbjct: 421 YVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQG 457


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  915 bits (2366), Expect = 0.0
 Identities = 457/482 (94%), Positives = 457/482 (94%), Gaps = 25/482 (5%)

Query: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60
           MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL
Sbjct: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60

Query: 61  INVDEVNQIVTTNVRLKQ-------------------------QWVDYNLKWNPDDYGGV 95
           INVDEVNQIVTTNVRLKQ                         QWVDYNLKWNPDDYGGV
Sbjct: 61  INVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGV 120

Query: 96  KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 155
           KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF
Sbjct: 121 KKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHF 180

Query: 156 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD 215
           PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD
Sbjct: 181 PFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPD 240

Query: 216 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV 275
           TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV
Sbjct: 241 TPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTV 300

Query: 276 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV 335
           FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV
Sbjct: 301 FLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKV 360

Query: 336 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA 395
           FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA
Sbjct: 361 FIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSA 420

Query: 396 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ 455
           IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ
Sbjct: 421 IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQ 480

Query: 456 QG 457
           QG
Sbjct: 481 QG 482


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  446 bits (1146), Expect = e-125
 Identities = 233/485 (48%), Positives = 313/485 (64%), Gaps = 40/485 (8%)

Query: 1   MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQL 60
           + P  LLLL  L    +   SE E RL  +LF+DY+ ++RPV +    V +   + + QL
Sbjct: 12  LSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQL 71

Query: 61  INVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF 120
           + VDEVNQI+ TN+ LKQ W DY LKWNP DYGG + + +P++KIW+PD+VLYNNA GDF
Sbjct: 72  VKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDF 131

Query: 121 AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP 180
            +   TK LL+YTG +TW PPAIFKS C+I VT+FPFD QNC+MK G+W+YD + + +  
Sbjct: 132 QVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL 191

Query: 181 ESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVII 240
                +L ++ ESGEW I ++ G+KH + Y+CC +  Y DITY   ++RLPL++ +N+II
Sbjct: 192 IGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEI-YPDITYSLYIRRLPLFYTINLII 250

Query: 241 PCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLF 300
           PCLL SFLT LVFYLP+D GEK+TL ISVLLSLTVFLLVI E IPSTS  +PLIG+Y+LF
Sbjct: 251 PCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLF 310

Query: 301 TMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFS--TMKRPSREKQD 358
           TM+FV  SI+ITV V+N H+R+P+TH MP+WV+ VF++ +P +MF +  T    + +K  
Sbjct: 311 TMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR 370

Query: 359 KKIFTEDIDISDISG------KPGPP----PMGF-HSPLIK------------------- 388
                E  +++  S       K G P      G+ H   IK                   
Sbjct: 371 PLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDA 430

Query: 389 -------HPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIG 441
                   PE+K AI+ +KYIAE MK+  E+     +WKYVAMV+D I L VF LVCI+G
Sbjct: 431 VLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILG 490

Query: 442 TLAVF 446
           T  +F
Sbjct: 491 TAGLF 495


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  424 bits (1091), Expect = e-119
 Identities = 214/466 (45%), Positives = 294/466 (63%), Gaps = 41/466 (8%)

Query: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQW 80
           +E E RL   LF+ Y+   RPV +   VV V  GL + QLI+VDE NQ++TTNV LKQ+W
Sbjct: 56  TETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEW 115

Query: 81  VDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTP 140
            DY L+WNP D+G +  + +PSE IW PD+VLYNNADG+FA+   TK  L  TG + W P
Sbjct: 116 SDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVP 175

Query: 141 PAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKE 200
           PAI+KS C I VT FPFD+QNC MK G+WTYD + + +       DL ++ ESGEW I  
Sbjct: 176 PAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVN 235

Query: 201 SRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG 260
           + G  +S  Y CC +  Y D+TY FV++RLPL++ +N+IIPCLL S LT LVFYLP+D G
Sbjct: 236 ATGTYNSKKYDCCAEI-YPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCG 294

Query: 261 EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH 320
           EK+TL ISVLLSLTVFLL+I E+IPSTS  +PLIG+Y+LFTM+FV  SI+ITV V+N HH
Sbjct: 295 EKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHH 354

Query: 321 RSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRP--------------------SREKQDKK 360
           RSPSTH MP+WVR   +  +P  +  +    P                    + + ++++
Sbjct: 355 RSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEERE 414

Query: 361 IFTEDID-----------ISDI-------SGKPGPPPMGF--HSPLIKHPEVKSAIEGIK 400
           +  E+ D           +  +       SG  GP          L+  P ++ A+EG+ 
Sbjct: 415 VVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVH 474

Query: 401 YIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVF 446
           YIA+ ++S+   ++   +WKYVAMV+D I L +F++VC +GT+ +F
Sbjct: 475 YIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLF 520


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  422 bits (1085), Expect = e-118
 Identities = 210/461 (45%), Positives = 299/461 (64%), Gaps = 29/461 (6%)

Query: 19  LGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQ 78
           +G   E RL  KLF  Y+  +RPVE+    V V   + + QL NVDEVNQI+ TN+ L+ 
Sbjct: 29  VGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRH 88

Query: 79  QWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITW 138
            W DY L+W+P +Y G++ + +P++KIW+PD+VLYNNA GDF +   TK LL+Y G ITW
Sbjct: 89  IWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITW 148

Query: 139 TPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVI 198
           TPPAIFKS C + +T FPFD QNCS+K G+WTYD + + +     + D+++F E+ EW I
Sbjct: 149 TPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEI 208

Query: 199 KESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTD 258
            ++ G+KH + Y+CC +  Y DITY F ++RLP+++ +N+IIPCL  SFLT LVFYLP+D
Sbjct: 209 IDASGYKHDIKYNCCEEI-YTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSD 267

Query: 259 SGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINT 318
            GEK+TL ISVLLSLTVFLLVI E IPSTS  VPL+G+Y+LFTM+FV  SI++TV V+N 
Sbjct: 268 CGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNI 327

Query: 319 HHRSPSTHVMPNWVRKVFIDTIPNIMFF-----------------STMKRPSREK----- 356
           H+R+P+TH MP WV+ VF+  +P ++                      +RP++ K     
Sbjct: 328 HYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHG 387

Query: 357 ---QDKKIF--TEDIDISDISGKPGPPPMGFHSPLIKH-PEVKSAIEGIKYIAETMKSDQ 410
                K+ F   +  +++    +    P+ +     +H PEV+  I  +++IAE MKS  
Sbjct: 388 EPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHN 447

Query: 411 ESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLI 451
           E+     +WKYVAMV+D + L VF++VC+ GT  +F   L+
Sbjct: 448 ETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLL 488


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  399 bits (1026), Expect = e-111
 Identities = 206/384 (53%), Positives = 263/384 (68%), Gaps = 14/384 (3%)

Query: 5   PLLLLFSLCSAGLVLGSEH-------ETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQL 57
           PLLLL      GL+  S H       E RL+ KLF  Y+   RPV +   VV V  GL +
Sbjct: 14  PLLLLLG---TGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70

Query: 58  IQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD 117
            QLI+VDE NQ++TTNV +KQ+W DY L+W+P DY  V  I IPSE IWRPD+VLYNNAD
Sbjct: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130

Query: 118 GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVA 177
           GDFA+   TK  L + G + WTPPAI+KS C I VT FPFD+QNC+MK G+WTYD + + 
Sbjct: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKID 190

Query: 178 INPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVN 237
           +     + D  +F ESGEWVI ++ G  ++  Y CC +  Y DITY FV++RLPL++ +N
Sbjct: 191 LVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEI-YPDITYAFVIRRLPLFYTIN 249

Query: 238 VIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKY 297
           +IIPCLL S LT LVFYLP++ GEK+TL ISVLLSLTVFLL+I E+IPSTS  +PLIG+Y
Sbjct: 250 LIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEY 309

Query: 298 MLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQ 357
           +LFTM+FV  SI+ITV V+N HHRSP TH MP WVR+VF+D +P ++    MKRPS  K 
Sbjct: 310 LLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLL---MKRPSVVKD 366

Query: 358 DKKIFTEDIDISDISGKPGPPPMG 381
           + +   E +     + +  P P G
Sbjct: 367 NCRRLIESMHKMASAPRFWPEPEG 390



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 30/70 (42%), Positives = 48/70 (68%), Gaps = 5/70 (7%)

Query: 377 PPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 436
           PPP   H PL   P +  A+EG++YIA+ +K++    +   +WKYVAMV+D I L +F++
Sbjct: 554 PPP---HLPL--SPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFII 608

Query: 437 VCIIGTLAVF 446
           VC++GT+ +F
Sbjct: 609 VCLLGTVGLF 618


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  387 bits (994), Expect = e-107
 Identities = 198/427 (46%), Positives = 278/427 (65%), Gaps = 24/427 (5%)

Query: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQW 80
           ++HE  L+  LF+DY   VRPVE     +++  GL + QL++VDE NQ++TTNV LKQ+W
Sbjct: 44  AKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEW 103

Query: 81  VDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTP 140
           +D  L+WNPDDYGG+K I +PS+ +W PD+VL++NADG F     TK +++Y G +TWTP
Sbjct: 104 IDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTS-TKTVIRYNGTVTWTP 162

Query: 141 PAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKE 200
           PA +KS C I VT FPFD QNCSMK G+WTYDGS V I  E    D  +F ++GEW I  
Sbjct: 163 PANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVS 222

Query: 201 SRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG 260
           + G K + T SCC    Y  +TY FV++RLPL++ + +IIPC+  SFLT LVFYLP++ G
Sbjct: 223 ATGSKGNRTDSCCW---YPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEG 279

Query: 261 EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH 320
           EK+ L  SVL+SLTVFLLVI E+IPS+S  +PLIG+Y++FTM+FV  SI++TV  IN HH
Sbjct: 280 EKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHH 339

Query: 321 RSPSTH-VMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPP 379
           RS STH  M   VRK+F+ T+P ++         R   D + FT+  +    SG      
Sbjct: 340 RSSSTHNAMAPLVRKIFLHTLPKLLCM-------RSHVD-RYFTQKEETESGSG------ 385

Query: 380 MGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI 439
                P      +++A++ I+YI   +  + +      +WK++A V+D + L  F+ V I
Sbjct: 386 -----PKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSI 440

Query: 440 IGTLAVF 446
           +G+L +F
Sbjct: 441 VGSLGLF 447


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  376 bits (966), Expect = e-104
 Identities = 197/484 (40%), Positives = 296/484 (61%), Gaps = 40/484 (8%)

Query: 3   PWPLLL---LFSLCSAGLVLGSEHETRLVAKLFKD--YSSVVRPVEDHRQVVEVTVGLQL 57
           P  LLL   L  LCS   V G++ E RLV  L     Y+ ++RP  +  ++V V + + L
Sbjct: 7   PVALLLGFGLLRLCSG--VWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSL 64

Query: 58  IQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD 117
            QLI+V E  QI+TTNV L Q+W DY L W P+++  +KK+ +PS+ IW PD+VLYNNAD
Sbjct: 65  AQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNAD 124

Query: 118 GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVA 177
           G + +  ++  ++ Y G I W PPAI+KS C+I V HFPFD+QNC+MK  +WTYD + + 
Sbjct: 125 GMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEID 184

Query: 178 INPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVN 237
           +  +S+   L +F  SGEW I    G ++        D+ Y+DITY F+++R PL++ +N
Sbjct: 185 LVLKSEVASLDDFTPSGEWDIVALPGRRNENP----DDSTYVDITYDFIIRRKPLFYTIN 240

Query: 238 VIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKY 297
           +IIPC+L + L  LVFYLP+D GEKMTL ISVLL+LTVFLL+I +++P TS  VPL+GKY
Sbjct: 241 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY 300

Query: 298 MLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFS---------- 347
           ++FTMV V  SI+ +V V+N HHRSP+TH M  WV+ VF++ +P ++F            
Sbjct: 301 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR 360

Query: 348 -TMKRPSREKQDK--------------KIFTEDIDISDISGKPGPPPMGFHSPLIKHPE- 391
             ++R  RE++                  F     +  ++G  G  P     P       
Sbjct: 361 LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC 420

Query: 392 ---VKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG 448
              ++ A++G+++IA+ M+S+ +  + + +WKYVAMV+D + L +F+ VC+ GT+ +F  
Sbjct: 421 GCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 480

Query: 449 RLIE 452
            L +
Sbjct: 481 PLFQ 484


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  374 bits (961), Expect = e-104
 Identities = 192/434 (44%), Positives = 279/434 (64%), Gaps = 13/434 (2%)

Query: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQW 80
           +E+E  L+  LF+ Y   VRPV      ++V  GL++ QL++VDE NQ++TTNV LKQ+W
Sbjct: 26  AENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEW 85

Query: 81  VDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTP 140
            D+ L+WNPDDYGG+  I +PSE +W PD+VL+ NADG F     TKV+++  G + WTP
Sbjct: 86  TDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTP 145

Query: 141 PAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKE 200
           PA +KS C + VT FPFD QNCSMK G+WTYDG++V +   ++  D  +F ++GEW I  
Sbjct: 146 PASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILN 205

Query: 201 SRGWK---HSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPT 257
           ++G K       YS      Y  ITY FV++RLPL++ + +IIPCL  SFLT LVFYLP+
Sbjct: 206 AKGMKGNRRDGVYS------YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPS 259

Query: 258 DSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVIN 317
           D GEK++LS SVL+SLTVFLLVI E+IPS+S  +PLIG+Y+LF M+FV  SII+TV VIN
Sbjct: 260 DEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVIN 319

Query: 318 THHRSPST-HVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPG 376
            HHRS ST H M  WV+++F+  +P ++         R    +K  ++ +    +  K  
Sbjct: 320 VHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK--DHVDRYSSPEKEESQPVVKGKVLEKKK 377

Query: 377 PPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 436
              +     ++    ++ A + I+YI+  +K +   +    +WK+VA V+D I L +F++
Sbjct: 378 QKQLSDGEKVLV-AFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLI 436

Query: 437 VCIIGTLAVFAGRL 450
           V + G++ +F   L
Sbjct: 437 VSVTGSVLIFTPAL 450


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  372 bits (954), Expect = e-103
 Identities = 196/483 (40%), Positives = 287/483 (59%), Gaps = 43/483 (8%)

Query: 6   LLLLFSLCSAGLVLGSEHETRLVAKLFKD--YSSVVRPVEDHRQVVEVTVGLQLIQLINV 63
           L  L +LC  G    +  E +L+  L     Y++++RP     Q++ + + L L QLI+V
Sbjct: 9   LFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISV 68

Query: 64  DEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIV 123
           +E  QI+TTNV LKQ+W DY L WN   Y GV  + IP+++IW PD+VLYNNADG + + 
Sbjct: 69  NEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVS 128

Query: 124 KFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESD 183
            +T ++++  G + W PPAI+KS C+I V +FPFD+QNC++K  +WTYD + + +   + 
Sbjct: 129 VYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTP 188

Query: 184 QPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCL 243
              + +F  SGEW I    G + +V      D  Y+D+TY F+++R PL++ +N+IIPC+
Sbjct: 189 TASMDDFTPSGEWDIVALPG-RRTVNPQ---DPSYVDVTYDFIIKRKPLFYTINLIIPCV 244

Query: 244 LFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMV 303
           L + L  LVFYLP+D GEKMTL ISVLL+LT FLL+I +++P TS  VPLIGKY++FTMV
Sbjct: 245 LTTLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMV 304

Query: 304 FVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIF- 362
            V  SI+ +V V+N HHRSPSTH M  WV++ F+  +P  +F   MKRP  +    + F 
Sbjct: 305 LVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLF---MKRPGPDSSPARAFP 361

Query: 363 -----TEDIDISDISGKP-----------GPPPMGFHSPLIKHP---------------- 390
                    + +  S  P            P      SP    P                
Sbjct: 362 PSKSCVTKPEATATSTSPSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFR 421

Query: 391 -EVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGR 449
            +V+ A+EG+ +IA+ MK+D E  +   +WKYVAMV+D + L VFM VC++GT+ +F   
Sbjct: 422 QDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPP 481

Query: 450 LIE 452
           L +
Sbjct: 482 LFQ 484


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  314 bits (804), Expect = 1e-85
 Identities = 171/477 (35%), Positives = 266/477 (55%), Gaps = 62/477 (12%)

Query: 19  LGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQ 78
           L  E + +L  +L K+Y+ + RPV +  Q + V   L L+Q+++VDE NQ++TTN+ L+ 
Sbjct: 21  LQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQM 80

Query: 79  QWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITW 138
            W D+ L+WN  +Y GVK +  P  +IW+PD++LYN+AD  F     T VL+  +GH  +
Sbjct: 81  SWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQY 140

Query: 139 TPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVI 198
            PP IFKS C I V  FPFD Q+C +K G+W+Y G   +++ +  + D+S ++ +GEW +
Sbjct: 141 LPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGG--WSLDLQMQEADISGYIPNGEWDL 198

Query: 199 KESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTD 258
               G +    Y CC + PY D+T+   M+R  LY+ +N++IPC+L S L  LVF LP D
Sbjct: 199 VGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPAD 257

Query: 259 SGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINT 318
           SGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI +Y   TM+ V  S+++TVIV+  
Sbjct: 258 SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQY 317

Query: 319 HHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREK-------QDKKIFTEDIDISDI 371
           HH  P    MP W R + ++      +F  MKRP  +K       + ++     +++S +
Sbjct: 318 HHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAV 374

Query: 372 SGKPGPPP--------MGF--------------------------HSPLIKH-------- 389
           +    PPP        +GF                          H   + H        
Sbjct: 375 A----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGD 430

Query: 390 PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILL---GVFMLVCIIGTL 443
           P++   +E ++YIA   +   ES    +EWK+ A V+D + L    VF ++C IG L
Sbjct: 431 PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGIL 487


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  313 bits (802), Expect = 2e-85
 Identities = 179/493 (36%), Positives = 271/493 (54%), Gaps = 53/493 (10%)

Query: 1   MEPWPLLLLFSLCSAGL---VLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQL 57
           M P  LL+L     A L   V GSE E RL  KLF  Y S VRP  +    V V+VGL L
Sbjct: 1   MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLIL 60

Query: 58  IQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD 117
            QLI+++E ++ ++T V L  +W DY L W+P ++ G+  + I +E +W PD+VL NN D
Sbjct: 61  AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND 120

Query: 118 GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVA 177
           G+F +     V++   G + W PP I++S C I VT+FPFD QNC+M   +++YD S V+
Sbjct: 121 GNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS 180

Query: 178 INP---------ESDQPDLSNFMESGEWVI--KESRGWKHSVTYSCCPDTPYLDITYHFV 226
           +           +        F+E+G+W I  K SR  +         +    ++ ++ +
Sbjct: 181 LQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLI 240

Query: 227 MQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPS 286
           ++R PL+++VNVI PC+L + L   VFYLP D+GEKM LSI  LL+LTVFLL++ + +P 
Sbjct: 241 IRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPE 300

Query: 287 TSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF 346
           TS +VP+I KY++FTMV V  S+I++V+V+N HHRSP TH MP WVR++FI  +P    +
Sbjct: 301 TSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLP---LY 357

Query: 347 STMKRPSREKQDKKIFTEDIDISDISGKPG---------PPPMGFHSP------------ 385
             +KRP   K ++ +  E    S      G          PP  F  P            
Sbjct: 358 LRLKRP---KPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAP 414

Query: 386 ------------LIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGV 433
                       +   PE++  +  I YIA  ++  ++ +    +W++VAMV+D + L  
Sbjct: 415 DLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWT 474

Query: 434 FMLVCIIGTLAVF 446
           F++   +GTL +F
Sbjct: 475 FIIFTSVGTLVIF 487


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  306 bits (785), Expect = 2e-83
 Identities = 166/459 (36%), Positives = 260/459 (56%), Gaps = 44/459 (9%)

Query: 22  EHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWV 81
           ++  +L   LF+DYS+ +RPVED  +V+ VT+ + L Q+ ++DE NQI+T  + ++Q W 
Sbjct: 29  KYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWH 88

Query: 82  DYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPP 141
           D  L W+ D Y G+  I IPS+ +WRPD+VLYN AD + +    T V+L+Y G ITW  P
Sbjct: 89  DAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAP 148

Query: 142 AIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKES 201
           AI KS C + VT+FPFD Q C++  G+WTY+G+ V I    D  DLS+F+E  EW +   
Sbjct: 149 AITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGM 208

Query: 202 RGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGE 261
              K+ ++Y CC + PY D+T+  +++R   ++IVN++IPC+L SFL  L FYLP  SGE
Sbjct: 209 PAVKNVISYGCCSE-PYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGE 267

Query: 262 KMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHR 321
           K++L +++LL++TVF L++ E++P+ S  VPLIGKY + TM  + AS  +T++V+N H  
Sbjct: 268 KVSLGVTILLAMTVFQLMVAEIMPA-SENVPLIGKYYIATMALITASTALTIMVMNIHFC 326

Query: 322 SPSTHVMPNWVRKVFIDTIPNIMFF---------------------------------ST 348
                 +P+W R V +  +  ++F                                  + 
Sbjct: 327 GAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAAR 386

Query: 349 MKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKS 408
            K  SR+K   K    D+      G  G  P    S   ++   K     I+YIA+ +K 
Sbjct: 387 NKDLSRKKDMNKRLKNDL------GCQGKNPQEAESYCAQY---KVLTRNIEYIAKCLKD 437

Query: 409 DQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFA 447
            + +N+  +EWK VA V+D   + +F ++  + T+ + A
Sbjct: 438 HKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIA 476


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  298 bits (764), Expect = 5e-81
 Identities = 173/489 (35%), Positives = 267/489 (54%), Gaps = 53/489 (10%)

Query: 7   LLLFSLCSAGLVLGS---EHETRLVAKLF--KDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61
           +L   L +A  V GS     E RL+  LF  K Y+  +RPV    + V+V + L L  LI
Sbjct: 5   VLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLI 64

Query: 62  NVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFA 121
           ++ EV + +TTNV ++  W D  LKWN +++G +  + +P + +W P++VL NN DG F 
Sbjct: 65  SLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQ 124

Query: 122 IVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPE 181
           I     VL+ + G + W PPAIF+S C I VT+FPFD QNCS+K  +  Y    + ++ +
Sbjct: 125 ISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLK 184

Query: 182 SDQP------------DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYL-DITYHFVMQ 228
            D              D   F E+GEW I   R  + +V      D+P   DIT++ +++
Sbjct: 185 QDAKENRTYPVEWIIIDPEGFTENGEWEIVH-RPARVNVDPRAPLDSPSRQDITFYLIIR 243

Query: 229 RLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTS 288
           R PL++I+N+++PC+L SF+  LVFYLP DSGEK +++ISVLL+ +VFLL+I + +P+TS
Sbjct: 244 RKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATS 303

Query: 289 SAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFST 348
            A+PLIGK++LF MV V   ++I VIV+N H R+PSTHV+   V+K+F++T+P ++    
Sbjct: 304 MAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH--- 360

Query: 349 MKRPSRE-----------------KQDKKIF----TEDIDISDISGKPG----------P 377
           M RP+ +                  + ++ F      D+     S + G          P
Sbjct: 361 MSRPAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRP 420

Query: 378 PPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLV 437
           P     +      E+K A++G  +I   M+     N     W  VA  +D + L V   V
Sbjct: 421 PASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPV 480

Query: 438 CIIGTLAVF 446
            ++GT  +F
Sbjct: 481 MVVGTAWIF 489


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  294 bits (753), Expect = 1e-79
 Identities = 154/445 (34%), Positives = 248/445 (55%), Gaps = 6/445 (1%)

Query: 6   LLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDE 65
           LLLLF L +  L        +L   LF +Y+S +RPV D  Q + VT+ + L Q+I++DE
Sbjct: 12  LLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDE 71

Query: 66  VNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF 125
            NQ++T  + ++Q+W D  L+W+P+ YGG+  I IPS  +WRPD+VLYN AD        
Sbjct: 72  RNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSAS 131

Query: 126 TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP 185
           T V+L++ G + W  PAI +S C + V  FPFD Q+C +  G+WT+ G  + + P     
Sbjct: 132 TNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAA 191

Query: 186 DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLF 245
            L++F+E+ EW +      +  +TY CC + PY D+T+  +++R    ++ N+++PC+L 
Sbjct: 192 SLADFVENVEWRVLGMPARRRVLTYGCCSE-PYPDVTFTLLLRRRAAAYVCNLLLPCVLI 250

Query: 246 SFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFV 305
           S L  L F+LP DSGEK++L ++VLL+LTVF L++ E +P   S VPLIGKY + TM  V
Sbjct: 251 SLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAES-VPLIGKYYMATMTMV 309

Query: 306 IASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTED 365
             S  +T++++N H+  PS   +P W R + +  +   +       P  + +  ++    
Sbjct: 310 TFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSP 369

Query: 366 IDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMV 425
                  G  GPP    H P     + ++ +  +  IA T +S + +     +WK +A V
Sbjct: 370 ---QSPEGGAGPPAGPCHEPRCLCRQ-EALLHHVATIANTFRSHRAAQRCHEDWKRLARV 425

Query: 426 MDHILLGVFMLVCIIGTLAVFAGRL 450
           MD   L +F  + ++ +L V    L
Sbjct: 426 MDRFFLAIFFSMALVMSLLVLVQAL 450


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  261 bits (668), Expect = 7e-70
 Identities = 137/349 (39%), Positives = 207/349 (59%), Gaps = 9/349 (2%)

Query: 5   PLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVD 64
           PLLLL  L       G   E RL+A L ++Y   +RP E    VV V++ L L  LI+++
Sbjct: 7   PLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLN 66

Query: 65  EVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVK 124
           E  + +TTNV ++ QW DY L+W+P DY G+  + +PS  +WRPD+VL NN DG F +  
Sbjct: 67  EREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVAL 126

Query: 125 FTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVV--AINPES 182
           +  VL+   G I W PPAIF+S C I VT+FPFD QNCS+   + TY  + +   ++ E 
Sbjct: 127 YCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQED 186

Query: 183 DQP------DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIV 236
            Q       D   F E+GEW I+           +   +  +  + ++ ++QR PL++++
Sbjct: 187 GQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVI 246

Query: 237 NVIIPCLLFSFLTGLVFYLPTDS-GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 295
           N+I PC+L S +  L+ +LP  + G+K T++I+VLL+ TVFL ++ + +P TS AVPLI 
Sbjct: 247 NIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLIS 306

Query: 296 KYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIM 344
           KY+ F +V  I  ++  V+V+N   RSP TH M   VRKVF+  +P ++
Sbjct: 307 KYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLL 355


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  258 bits (658), Expect = 1e-68
 Identities = 146/474 (30%), Positives = 246/474 (51%), Gaps = 30/474 (6%)

Query: 3   PWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLIN 62
           P  +LLL  L   G+  G   E RL   LF +Y    RPV +    V +++ + L  LI+
Sbjct: 5   PLGVLLLLGLLGRGV--GKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLIS 62

Query: 63  VDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAI 122
           ++E  + +TT+V +   W DY L ++ DD+GG++ + +PSE +W P++VL NN DG F +
Sbjct: 63  LNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGV 122

Query: 123 VKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPES 182
                VL+   G +TW PPAI++S C + VT+FPFD QNCS+   + TY+   V      
Sbjct: 123 AYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAV 182

Query: 183 DQP---------DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLY 233
           D           D   + E+GEW I    G                D+ Y  +++R PL+
Sbjct: 183 DNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLF 242

Query: 234 FIVNVIIPCLLFSFLTGLVFYLPTDS-GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVP 292
           +++N+I+PC+L S L  L ++LP  + G+K T+SI+VLL+ TVFL +I + IP TS +VP
Sbjct: 243 YVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVP 302

Query: 293 LIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIM-------- 344
           L+G++++F MV     ++  VIV+N   R+P+TH M   +R V ++ +P ++        
Sbjct: 303 LLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEA 362

Query: 345 --FFSTMKRPS-------REKQDKKIFTEDIDISDISGKPGPPPMGFHSPL-IKHPEVKS 394
               S  +R S        E+   K    ++       + G     F   L    PEV+ 
Sbjct: 363 PRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEVRC 422

Query: 395 AIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG 448
            ++ + ++AE+ +  + +    ++W  +   +D+I     +++  +G+  +F G
Sbjct: 423 CVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLG 476


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  225 bits (573), Expect = 7e-59
 Identities = 131/380 (34%), Positives = 201/380 (52%), Gaps = 62/380 (16%)

Query: 116 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 175
           AD  F     T VL+  +GH  + PP IFKS C I V  FPFD Q+C +K G+W+Y G  
Sbjct: 28  ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGW- 86

Query: 176 VAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFI 235
            +++ +  + D+S ++ +GEW +    G +    Y CC + PY D+T+   M+R  LY+ 
Sbjct: 87  -SLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYG 144

Query: 236 VNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIG 295
           +N++IPC+L S L  LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI 
Sbjct: 145 LNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIA 204

Query: 296 KYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSRE 355
           +Y   TM+ V  S+++TVIV+  HH  P    MP W R + ++      +F  MKRP  +
Sbjct: 205 QYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGED 261

Query: 356 K-------QDKKIFTEDIDISDISGKPGPPP--------MGF------------------ 382
           K       + ++     +++S ++    PPP        +GF                  
Sbjct: 262 KVRPACQHKQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVC 317

Query: 383 --------HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVM 426
                   H   + H        P++   +E ++YIA   +   ES    +EWK+ A V+
Sbjct: 318 GRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVV 377

Query: 427 DHILL---GVFMLVCIIGTL 443
           D + L    VF ++C IG L
Sbjct: 378 DRLCLMAFSVFTIICTIGIL 397


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  202 bits (515), Expect = 4e-52
 Identities = 126/461 (27%), Positives = 231/461 (50%), Gaps = 38/461 (8%)

Query: 7   LLLFSLCSAGLVLGSEHETR-----LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61
           LLL +L + G    S + TR     L   L  +Y   VRPV D R+   V++ + +  ++
Sbjct: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77

Query: 62  NVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD-GDF 120
           NVDE NQ++TT +  +Q W D  L+WNP+D+  + K+ IP++ IW PD+++    D G  
Sbjct: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS 137

Query: 121 AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAIN- 179
             + +  V +++ G +    P    + C + + +FPFD QNCS+   +W +    + I+ 
Sbjct: 138 PNIPY--VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL 195

Query: 180 ---PESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIV 236
              PE  + D S FM  GEW +     +     +S      Y ++ ++ V++R PL+++V
Sbjct: 196 WRLPEKVKSDRSVFMNQGEWELLGVLPYFRE--FSMESSNYYAEMKFYVVIRRRPLFYVV 253

Query: 237 NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK 296
           ++++P +    +  + FYLP +SGE+++  I++LL  +VFL+++ + +P+T+   PLIG 
Sbjct: 254 SLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGV 313

Query: 297 YMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF---STMKRPS 353
           Y +  M  ++ S+  T+ ++   H+      +P W+R + ++ I  ++     ST +RP 
Sbjct: 314 YFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPP 373

Query: 354 REKQDKKIFTEDIDI-----------SDISGKP----GPPPMGFHSPLIKHPEVKSAIEG 398
              Q  K  T+D               D    P     PPP    + L     V   ++ 
Sbjct: 374 ATSQATK--TDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASL----AVCGLLQE 427

Query: 399 IKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCI 439
           +  I + ++   E    A +W  V  V+D +L  +++L  +
Sbjct: 428 LSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVL 468


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  201 bits (511), Expect = 1e-51
 Identities = 119/437 (27%), Positives = 221/437 (50%), Gaps = 33/437 (7%)

Query: 26  RLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNL 85
           RL   L  +Y   VRPV D R+   V++ + +  ++NVDE NQ++TT +  +Q W D  L
Sbjct: 21  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 80

Query: 86  KWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD-GDFAIVKFTKVLLQYTGHITWTPPAIF 144
           +WNP+D+  + K+ IP++ IW PD+++    D G    + +  V +++ G +    P   
Sbjct: 81  QWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPY--VYIRHQGEVQNYKPLQV 138

Query: 145 KSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAIN----PESDQPDLSNFMESGEWVIKE 200
            + C + + +FPFD QNCS+   +W +    + I+    PE  + D S FM  GEW +  
Sbjct: 139 VTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLG 198

Query: 201 SRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG 260
              +     +S      Y ++ ++ V++R PL+++V++++P +    +  + FYLP +SG
Sbjct: 199 VLPYFRE--FSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSG 256

Query: 261 EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH 320
           E+++  I++LL  +VFL+++ + +P+T+   PLIG Y +  M  ++ S+  T+ ++   H
Sbjct: 257 ERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVH 316

Query: 321 RSPSTHVMPNWVRKVFIDTIPNIMFF---STMKRPSREKQDKKIFTEDIDI--------- 368
           +      +P W+R + ++ I  ++     ST +RP    Q  K  T+D            
Sbjct: 317 KQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATK--TDDCSAMGNHCSHMG 374

Query: 369 --SDISGKP----GPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYV 422
              D    P     PPP    + L     V   ++ +  I + ++   E    A +W  V
Sbjct: 375 GPQDFEKSPRDRCSPPPPPREASL----AVCGLLQELSSIRQFLEKRDEIREVARDWLRV 430

Query: 423 AMVMDHILLGVFMLVCI 439
             V+D +L  +++L  +
Sbjct: 431 GSVLDKLLFHIYLLAVL 447


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  189 bits (479), Expect = 6e-48
 Identities = 127/493 (25%), Positives = 232/493 (47%), Gaps = 70/493 (14%)

Query: 7   LLLFSLCSAGLVLGSEHETR-----LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLI 61
           LLL +L + G    S + TR     L   L  +Y   VRPV D R+   V++ + +  ++
Sbjct: 18  LLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAIL 77

Query: 62  NVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD-GDF 120
           NVDE NQ++TT +  +Q W D  L+WNP+D+  + K+ IP++ IW PD+++    D G  
Sbjct: 78  NVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKS 137

Query: 121 AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAIN- 179
             + +  V +++ G +    P    + C + + +FPFD QNCS+   +W +    + I+ 
Sbjct: 138 PNIPY--VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL 195

Query: 180 ---PESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIV 236
              PE  + D S FM  GEW +     +     +S      Y ++ ++ V++R PL+++V
Sbjct: 196 WRLPEKVKSDRSVFMNQGEWELLGVLPYFRE--FSMESSNYYAEMKFYVVIRRRPLFYVV 253

Query: 237 NVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK 296
           ++++P +    +  + FYLP +SGE+++  I++LL  +VFL+++ + +P+T+   PLIGK
Sbjct: 254 SLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGK 313

Query: 297 --------------------------------YMLFTMVFVIASIIITVIVINTHHRSPS 324
                                           Y +  M  ++ S+  T+ ++   H+   
Sbjct: 314 APPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDL 373

Query: 325 THVMPNWVRKVFIDTIPNIMFF---STMKRPSREKQDKKIFTEDIDI-----------SD 370
              +P W+R + ++ I  ++     ST +RP    Q  K  T+D               D
Sbjct: 374 QQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATK--TDDCSAMGNHCSHMGGPQD 431

Query: 371 ISGKP----GPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVM 426
               P     PPP    + L     V   ++ +  I + ++   E    A +W  V  V+
Sbjct: 432 FEKSPRDRCSPPPPPREASL----AVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVL 487

Query: 427 DHILLGVFMLVCI 439
           D +L  +++L  +
Sbjct: 488 DKLLFHIYLLAVL 500


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  174 bits (440), Expect = 2e-43
 Identities = 103/312 (33%), Positives = 162/312 (51%), Gaps = 60/312 (19%)

Query: 184 QPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCL 243
           + D+S ++ +GEW +    G +    Y CC + PY D+T+   M+R  LY+ +N++IPC+
Sbjct: 3   EADISGYIPNGEWDLVGIPGKRSERFYECCKE-PYPDVTFTVTMRRRTLYYGLNLLIPCV 61

Query: 244 LFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMV 303
           L S L  LVF LP DSGEK++L I+VLLSLTVF+L++ E++P+TS +VPLI +Y   TM+
Sbjct: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121

Query: 304 FVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREK------- 356
            V  S+++TVIV+  HH  P    MP W R + ++      +F  MKRP  +K       
Sbjct: 122 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNW---CAWFLRMKRPGEDKVRPACQH 178

Query: 357 QDKKIFTEDIDISDISGKPGPPP--------MGF-------------------------- 382
           + ++     +++S ++    PPP        +GF                          
Sbjct: 179 KQRRCSLASVEMSAVA----PPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPT 234

Query: 383 HSPLIKH--------PEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILL--- 431
           H   + H        P++   +E ++YIA   +   ES    +EWK+ A V+D + L   
Sbjct: 235 HDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAF 294

Query: 432 GVFMLVCIIGTL 443
            VF ++C IG L
Sbjct: 295 SVFTIICTIGIL 306


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  130 bits (326), Expect = 3e-30
 Identities = 92/416 (22%), Positives = 187/416 (44%), Gaps = 48/416 (11%)

Query: 40  RPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIH 99
           RPV +     +V +   +  +++V+E   ++++ + L+  W +  + WNP++  G+ K+ 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 100 IPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYT---GHITWTPPAIFKSYCEIIVTHFP 156
           + ++ +W PD+ +    D D    K  K L  Y    G I +  P    S C + + +FP
Sbjct: 130 MAAKNLWLPDIFIIELMDVD----KTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFP 185

Query: 157 FDEQNCSMKLGTWTYDGSVVAINPESDQPDLS----NFMES-GEWVIKESRGWKHSVTYS 211
           FD+QNC++   ++ Y    + ++ E +  +++    N +++ GEW   E  G   +    
Sbjct: 186 FDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEW---ELLGLSKATAKL 242

Query: 212 CCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLL 271
                 Y  I ++  ++R P  +++N+++P      +  L FYLP  SG ++   I++LL
Sbjct: 243 SRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLL 302

Query: 272 SLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVIN-THHRSPSTHVMPN 330
              VFLL++ +L+P  +S  PLIG Y    +  ++ S++ T+ + +  H  +     +P 
Sbjct: 303 GYNVFLLMMSDLLP--TSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPR 360

Query: 331 WVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHP 390
           W+  + +    N         P +E +                  GP     H P +K P
Sbjct: 361 WLHSLLLHC--NSPGRCCPTAPQKENK------------------GPGLTPTHLPGVKEP 400

Query: 391 EVKSA----------IEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 436
           EV +             G ++     + + +  ++   W   +  MD +L  +++L
Sbjct: 401 EVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLL 456


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  128 bits (322), Expect = 9e-30
 Identities = 86/321 (26%), Positives = 152/321 (47%), Gaps = 18/321 (5%)

Query: 12  LCSAGLVLGSEHETR------LVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDE 65
           L +AG++    H  +      L  +L + Y   VRPV +  +   V + L +  +++VD 
Sbjct: 14  LVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDA 73

Query: 66  VNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKF 125
            NQI+ T+V  ++ W D  L WN   +  +++I +P   IW PD+++    D +      
Sbjct: 74  ENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIE-RYPDL 132

Query: 126 TKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAI----NPE 181
             V +  +G I    P    S C +    FPFD QNCS+   +  +    V +    +PE
Sbjct: 133 PYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPE 192

Query: 182 SDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTP--YLDITYHFVMQRLPLYFIVNVI 239
             Q D   F+   EW +        S TYS    +   +  I ++ VM+R PL ++V+++
Sbjct: 193 DIQHDKKAFLNDSEWELLSV-----SSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLL 247

Query: 240 IPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYML 299
           IP +    +    FYLP +   ++    SVL+  TVF + +   +P +  + PLIG +  
Sbjct: 248 IPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFT 307

Query: 300 FTMVFVIASIIITVIVINTHH 320
             M F++ S+  +++++   H
Sbjct: 308 ICMAFLVLSLAKSIVLVKFLH 328


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  123 bits (309), Expect = 3e-28
 Identities = 74/304 (24%), Positives = 142/304 (46%), Gaps = 12/304 (3%)

Query: 40  RPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIH 99
           RP  ++     V +   L  ++ VD   Q++T+ + +   W +  + WNP +  G+ K+ 
Sbjct: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114

Query: 100 IPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDE 159
           + +E +W PD+ +  + D D      T   +   G I +  P    S C + + +FPFD+
Sbjct: 115 VLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173

Query: 160 QNCSMKLGTWTYDGSVVAINPESDQPDLSN-----FMESGEWVIKESRGWKHSVTYSCCP 214
           QNC+    ++ Y    + +  + +  ++++         GEW   E  G   +       
Sbjct: 174 QNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEW---ELLGINKATPKMSMG 230

Query: 215 DTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLT 274
           +  Y  I ++  ++R P  +I+N+++P      +  L FYLP +S  +    I++LL   
Sbjct: 231 NNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYN 290

Query: 275 VFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITV-IVINTHHRSPSTHVMPNWVR 333
           VFLL++ +L+P  +S  PLI  Y    +  ++ S++ TV I    H  +     MP W+ 
Sbjct: 291 VFLLMMNDLLP--ASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLH 348

Query: 334 KVFI 337
            + +
Sbjct: 349 SLLL 352


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 63/268 (23%), Positives = 126/268 (47%), Gaps = 11/268 (4%)

Query: 49  VEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWN--PDDYGGVKKIHIPSEKIW 106
           V VT  + +    +V E       N+ L+QQW D  L ++  PDD   +    + S  IW
Sbjct: 71  VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDS--IW 128

Query: 107 RPDLVLYNNADGDFAIVKFTKVLLQYT--GHITWTPPAIFKSYCEIIVTHFPFDEQNCSM 164
           +PDL   N    +F  V     LL+ +  G + ++        C + + +FP D Q C+M
Sbjct: 129 KPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTM 188

Query: 165 KLGTWTYDGSVVAINPESDQP-DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITY 223
           +L ++ Y  + +     SD P  ++  +   ++++KE +   +   +        +++ +
Sbjct: 189 QLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKF 248

Query: 224 HFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-EKMTLSISVLLSLTVFLLVIVE 282
           H  ++R   Y+++ + IP LL   L+ + F++  D+   ++ L I+ +L++T        
Sbjct: 249 H--LERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRA 306

Query: 283 LIPSTSSAVPLIGKYMLFTMVFVIASII 310
            +P   S V  I  +M   ++FV A+++
Sbjct: 307 SLPKV-SYVKAIDIWMAVCLLFVFAALL 333


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 63/268 (23%), Positives = 126/268 (47%), Gaps = 11/268 (4%)

Query: 49  VEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWN--PDDYGGVKKIHIPSEKIW 106
           V VT  + +    +V E       N+ L+QQW D  L ++  PDD   +    + S  IW
Sbjct: 71  VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDS--IW 128

Query: 107 RPDLVLYNNADGDFAIVKFTKVLLQYT--GHITWTPPAIFKSYCEIIVTHFPFDEQNCSM 164
           +PDL   N    +F  V     LL+ +  G + ++        C + + +FP D Q C+M
Sbjct: 129 KPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTM 188

Query: 165 KLGTWTYDGSVVAINPESDQP-DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITY 223
           +L ++ Y  + +     SD P  ++  +   ++++KE +   +   +        +++ +
Sbjct: 189 QLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKF 248

Query: 224 HFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-EKMTLSISVLLSLTVFLLVIVE 282
           H  ++R   Y+++ + IP LL   L+ + F++  D+   ++ L I+ +L++T        
Sbjct: 249 H--LERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRA 306

Query: 283 LIPSTSSAVPLIGKYMLFTMVFVIASII 310
            +P   S V  I  +M   ++FV A+++
Sbjct: 307 SLPKV-SYVKAIDIWMAVCLLFVFAALL 333


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 62/268 (23%), Positives = 126/268 (47%), Gaps = 11/268 (4%)

Query: 49  VEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWN--PDDYGGVKKIHIPSEKIW 106
           V VT  + +    ++ E       N+ L+QQW D  L ++  PDD   +    + S  IW
Sbjct: 71  VNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDS--IW 128

Query: 107 RPDLVLYNNADGDFAIVKFTKVLLQYT--GHITWTPPAIFKSYCEIIVTHFPFDEQNCSM 164
           +PDL   N    +F  V     LL+ +  G + ++        C + + +FP D Q C+M
Sbjct: 129 KPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTM 188

Query: 165 KLGTWTYDGSVVAINPESDQP-DLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITY 223
           +L ++ Y  + +     SD P  ++  +   ++++KE +   +   +        +++ +
Sbjct: 189 QLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKF 248

Query: 224 HFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-EKMTLSISVLLSLTVFLLVIVE 282
           H  ++R   Y+++ + IP LL   L+ + F++  D+   ++ L I+ +L++T        
Sbjct: 249 H--LERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRA 306

Query: 283 LIPSTSSAVPLIGKYMLFTMVFVIASII 310
            +P   S V  I  +M   ++FV A+++
Sbjct: 307 SLPKV-SYVKAIDIWMAVCLLFVFAALL 333


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 66/303 (21%), Positives = 131/303 (43%), Gaps = 33/303 (10%)

Query: 25  TRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYN 84
           TR++ +L   Y + +RP      + EV   + +     V + +   T +V  +Q+W D  
Sbjct: 43  TRILDRLLDGYDNRLRPGLGD-SITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDER 101

Query: 85  LKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLL--QYTGHITWTPPA 142
           LK+       ++  ++ + KIW PD   +N        +     LL  Q  G + +T   
Sbjct: 102 LKFK-GPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRL 160

Query: 143 IFKSYCEIIVTHFPFDEQNCSMKLGT-----------WTYDGS-VVAINPESDQPDLSNF 190
             ++ C + +  FP D  +C +K G+           WTY+ S  V + P+  + +  + 
Sbjct: 161 TVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDL 220

Query: 191 MES--GEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFL 248
           +    G+  IK S G              Y  +T HF ++R   YF++   +PC++   L
Sbjct: 221 LGQSIGKETIKSSTG-------------EYTVMTAHFHLKRKIGYFVIQTYLPCIMTVIL 267

Query: 249 TGLVFYLPTDSGEKMTL-SISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIA 307
           + + F+L  +S    T+  ++ +L++T   +     +P  + A  +   ++     FV +
Sbjct: 268 SQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAM-DWFIAVCYAFVFS 326

Query: 308 SII 310
           ++I
Sbjct: 327 ALI 329


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 66/303 (21%), Positives = 131/303 (43%), Gaps = 33/303 (10%)

Query: 25  TRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYN 84
           TR++ +L   Y + +RP      + EV   + +     V + +   T +V  +Q+W D  
Sbjct: 43  TRILDRLLDGYDNRLRPGLGD-SITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDER 101

Query: 85  LKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLL--QYTGHITWTPPA 142
           LK+       ++  ++ + KIW PD   +N        +     LL  Q  G + +T   
Sbjct: 102 LKFK-GPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRL 160

Query: 143 IFKSYCEIIVTHFPFDEQNCSMKLGT-----------WTYDGS-VVAINPESDQPDLSNF 190
             ++ C + +  FP D  +C +K G+           WTY+ S  V + P+  + +  + 
Sbjct: 161 TVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDL 220

Query: 191 MES--GEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFL 248
           +    G+  IK S G              Y  +T HF ++R   YF++   +PC++   L
Sbjct: 221 LGQSIGKETIKSSTG-------------EYTVMTAHFHLKRKIGYFVIQTYLPCIMTVIL 267

Query: 249 TGLVFYLPTDSGEKMTL-SISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIA 307
           + + F+L  +S    T+  ++ +L++T   +     +P  + A  +   ++     FV +
Sbjct: 268 SQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAM-DWFIAVCYAFVFS 326

Query: 308 SII 310
           ++I
Sbjct: 327 ALI 329


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,467,026
Number of Sequences: 37866
Number of extensions: 774913
Number of successful extensions: 2014
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 1848
Number of HSP's gapped (non-prelim): 91
length of query: 457
length of database: 18,247,518
effective HSP length: 106
effective length of query: 351
effective length of database: 14,233,722
effective search space: 4996036422
effective search space used: 4996036422
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.