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Search of human proteins with 4557325
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557325 apolipoprotein E precursor [Homo sapiens]
(317 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557325 apolipoprotein E precursor [Homo sapiens] 615 e-176
gi|71773110 apolipoprotein A-IV precursor [Homo sapiens] 98 1e-20
gi|4557321 apolipoprotein A-I preproprotein [Homo sapiens] 59 7e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 56 4e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 56 4e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 56 4e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 56 4e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 56 4e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 56 4e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 56 4e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 56 4e-08
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 55 1e-07
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 55 1e-07
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 55 1e-07
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 55 1e-07
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 54 1e-07
gi|226495417 coiled-coil domain containing 102A [Homo sapiens] 54 2e-07
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 52 9e-07
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 52 9e-07
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 52 9e-07
gi|156104908 myosin heavy chain 6 [Homo sapiens] 52 9e-07
gi|63079709 apolipoprotein AV [Homo sapiens] 51 1e-06
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 51 1e-06
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 50 3e-06
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 50 3e-06
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 50 3e-06
gi|93102364 SWAP-70 protein [Homo sapiens] 50 3e-06
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 49 4e-06
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 49 8e-06
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 49 8e-06
>gi|4557325 apolipoprotein E precursor [Homo sapiens]
Length = 317
Score = 615 bits (1585), Expect = e-176
Identities = 317/317 (100%), Positives = 317/317 (100%)
Query: 1 MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT 60
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT
Sbjct: 1 MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT 60
Query: 61 LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA 120
LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA
Sbjct: 61 LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA 120
Query: 121 RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY 180
RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY
Sbjct: 121 RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY 180
Query: 181 QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG 240
QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG
Sbjct: 181 QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG 240
Query: 241 SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK 300
SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK
Sbjct: 241 SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK 300
Query: 301 VQAAVGTSAAPVPSDNH 317
VQAAVGTSAAPVPSDNH
Sbjct: 301 VQAAVGTSAAPVPSDNH 317
>gi|71773110 apolipoprotein A-IV precursor [Homo sapiens]
Length = 396
Score = 97.8 bits (242), Expect = 1e-20
Identities = 60/265 (22%), Positives = 131/265 (49%), Gaps = 18/265 (6%)
Query: 52 WDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARL 111
WDY + +++ E L S++TQ+L AL + + E+ Y +L+++L P A E RL
Sbjct: 32 WDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERL 91
Query: 112 SKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDAD 171
+K+ + + +G ++E++ RL+ + EV +G + EL+ RL + +LR ++ A+
Sbjct: 92 AKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAE 151
Query: 172 DLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE---RAQAW 228
L+++L Y A+R +RE L R A + + Q ++E R +
Sbjct: 152 QLRRQLTPY-------AQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPY 204
Query: 229 GERLRARMEE--------MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
+ + ++++ + +D +++ Q+ + ++++ A++++ + A L+
Sbjct: 205 ADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELR 264
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAAV 305
PL ED++ G E +Q ++
Sbjct: 265 QRLAPLAEDVRGNLRGNTEGLQKSL 289
Score = 53.9 bits (128), Expect = 2e-07
Identities = 53/212 (25%), Positives = 97/212 (45%), Gaps = 25/212 (11%)
Query: 77 ELRALMDETMKELKA----YKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGR 132
EL+A +D+ ++ELK Y E + ++ EE R L+ Q Q +L +E + +
Sbjct: 185 ELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQ 244
Query: 133 LVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGL 192
+ + E++A + S EELR RLA +R L + + LQK LA + G ++ +
Sbjct: 245 MKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLA--ELGGH--LDQQV 300
Query: 193 SAIRERLGP--------LVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTR 244
R R+ P LV+Q +G AG ++ + LR ++ S +
Sbjct: 301 EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGD-VEGHLSFLEKDLRDKVNSFFSTFK 359
Query: 245 DR--------LDEVKEQVAEVRAKLEEQAQQI 268
++ L E+++Q + + + +EQ Q +
Sbjct: 360 EKESQDKTLSLPELEQQQEQQQEQQQEQVQML 391
Score = 39.7 bits (91), Expect = 0.004
Identities = 35/149 (23%), Positives = 64/149 (42%), Gaps = 20/149 (13%)
Query: 57 WVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARL---SK 113
+ Q E++ +L +T +++ +E + A EL ++L P+AE+ R L ++
Sbjct: 226 YAQDTQEKLNHQL--EGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTE 283
Query: 114 ELQAAQARLGADM----EDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRD 169
LQ + A LG + E+ R+ Y L Q E+LR +L H
Sbjct: 284 GLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPH----------- 332
Query: 170 ADDLQKRLAVYQAGAREGAERGLSAIRER 198
A D++ L+ + R+ S +E+
Sbjct: 333 AGDVEGHLSFLEKDLRDKVNSFFSTFKEK 361
>gi|4557321 apolipoprotein A-I preproprotein [Homo sapiens]
Length = 267
Score = 58.5 bits (140), Expect = 7e-09
Identities = 61/293 (20%), Positives = 116/293 (39%), Gaps = 26/293 (8%)
Query: 1 MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT 60
MK L V FL G QA+ + P+ W+ Y+ ++
Sbjct: 1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSP------------WDRVKDLATVYVDVLKD 48
Query: 61 LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA 120
+ S + ++L + + + + S+L EQL PV +E L KE + +
Sbjct: 49 SGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQ 108
Query: 121 RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY 180
+ D+E+V ++ Y + Q + E R ++ +L++ + +LQ++L+
Sbjct: 109 EMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPL 168
Query: 181 QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG 240
R+ A + A+R L P ++ R R A R +A E AR+ E
Sbjct: 169 GEEMRDRARAHVDALRTHLAPYSDELRQRLAA-----------RLEALKENGGARLAEYH 217
Query: 241 SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQ 293
++ + L + E + + LE+ Q + E+F+ S E + + Q
Sbjct: 218 AKATEHLSTLSE---KAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ 267
Score = 28.9 bits (63), Expect = 6.3
Identities = 15/77 (19%), Positives = 37/77 (48%), Gaps = 4/77 (5%)
Query: 222 QERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAK----LEEQAQQIRLQAEAFQA 277
Q A G++L ++ + +++EQ+ V + LE++ + +R +
Sbjct: 56 QFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLE 115
Query: 278 RLKSWFEPLVEDMQRQW 294
+K+ +P ++D Q++W
Sbjct: 116 EVKAKVQPYLDDFQKKW 132
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 56.2 bits (134), Expect = 4e-08
Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 17 QAKVE-QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVT 75
QA+ E Q E E E R + E Q+ ++ ELA ++++++ ++ T
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELA--------------EQELEKQRQLAEGT 1704
Query: 76 QELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ R ++ + L+A ++E EQ + EE ARL +E AA Q
Sbjct: 1705 AQQRLAAEQELIRLRA-ETEQGEQQRQLLEEELARLQREAAAA---------------TQ 1748
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGA-REGAERG--L 192
R E++A L + E+ V LAS R + R + K+ +AG RE AE L
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Query: 193 SAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARME-EMGSRTRD----RL 247
A+ E + AA + A + L E+ A GE R + E E+ + ++ RL
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 248 DEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEP-------LVEDMQRQWAGLVEK 300
+ E A R +LEEQA Q + E A+L+ + LVED RQ + E+
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 301 VQA 303
+ A
Sbjct: 1927 ILA 1929
Score = 55.1 bits (131), Expect = 8e-08
Identities = 65/245 (26%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 56 RWVQTLSEQVQEELLSSQ-----VTQELRALMDETMKELKAYKSELEEQL--TPVAEETR 108
R + L +++QEE++ + Q+ R++ +E + ++ ++E++ + AE +R
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 109 ARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTE-ELRVRLASHLRKLRKRLL 167
R+ +E++ + +L A G GE+QA+ ++ E E + R A + +R +
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGA----EGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 168 RDADDLQKRLAVYQAGAREGAE--------RGLSAIRE-RLGPLVEQGRVRAATVG---- 214
+D + +KR A + +R AE R L A+ E RL + R+R A V
Sbjct: 1504 QD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 215 -SLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
+A + Q A+A + RA E ++ L E VA++R + E +AQQ QAE
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAE 1619
Query: 274 AFQAR 278
A +AR
Sbjct: 1620 AERAR 1624
Score = 52.0 bits (123), Expect = 7e-07
Identities = 81/294 (27%), Positives = 128/294 (43%), Gaps = 33/294 (11%)
Query: 14 AGCQAKVEQA-VETEPEPELRQQTEWQSGQRWELALGRFWDYLRWV-QTLSE--QVQEEL 69
A QA E+ E E E R Q E + ++ + A + ++ QTL + QV++EL
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 70 ----LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEE---TRARLSKELQAAQARL 122
L + T + L+DE ++ LKA +E Q + V EE R ++ +EL +AR+
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-EELSKLKARI 2247
Query: 123 GADM-------EDVCGRLVQYRGEVQAMLGQSTEELRV--RLASHLRKLRKRLLRD---- 169
A+ +D R +Q E + + L V + A+ LR+L + L
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 170 -ADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L++++ Q R AE L ++ L EQ R R Q L E Q +
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQAR-RLQEDKEQMAQQLAEETQGF 2364
Query: 229 GERL---RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL 279
L R R EM S +RL +++ +A+ EE AQ+ R QAE +L
Sbjct: 2365 QRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Score = 50.1 bits (118), Expect = 3e-06
Identities = 69/270 (25%), Positives = 119/270 (44%), Gaps = 30/270 (11%)
Query: 63 EQVQEELLSSQVTQELRALMDETMKEL-KAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
E Q L Q Q +A ++E + +L KA SELE Q V + R R ++++
Sbjct: 1873 EAFQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQR--RQVEEEILA 1929
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLL--------RDADD- 172
L A E + E+ + + + LR + + L R+R L R+A++
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 173 LQKRLAVYQAGAR------EGAERGLSAIRE--RLGPLVEQGRVRAATVGSLAGQP---L 221
+QK LA + AR E ER + + E RL EQ R + A Q
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 222 QERAQAWG-ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
+E+A A+ ++ +++ + + LD+++ + AE + E+A++ R+QAE A+ +
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAAVGTSAA 310
VE+ +R E+ QA AA
Sbjct: 2109 R----QVEEAERLKQSAEEQAQARAQAQAA 2134
Score = 48.9 bits (115), Expect = 6e-06
Identities = 62/243 (25%), Positives = 106/243 (43%), Gaps = 38/243 (15%)
Query: 54 YLRWV-QTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLS 112
Y++++ +TL +EE L+ Q E R + E L E + QL + +A+
Sbjct: 1333 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQAE 1387
Query: 113 KELQAAQARLGADM---EDVCGRLVQYRGEVQA---MLGQSTE---ELRVRLASHLRKLR 163
+E + Q R+ ++ E+ Q + +Q L QS+E + + R A + R
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 164 KRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 223
R+ + ++ +L + R GAE L A+R R Q R
Sbjct: 1448 LRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKR---------------- 1490
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQV-AEVRAKLEEQA-----QQIRLQAEAFQA 277
+AQ ERLR ++++ R R E+ +V AE A E+Q +++RLQAE +
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550
Query: 278 RLK 280
RL+
Sbjct: 1551 RLR 1553
Score = 48.9 bits (115), Expect = 6e-06
Identities = 58/270 (21%), Positives = 120/270 (44%), Gaps = 26/270 (9%)
Query: 14 AGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQ 73
A +A+ + A E +LR++ E ++ +R + LR Q ++++ ++
Sbjct: 2125 AQARAQAQAAAE-----KLRKEAEQEAARRAQAEQAA----LRQKQAADAEMEKHKKFAE 2175
Query: 74 VTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRL 133
T +A +++ + L+ E + Q + EE + ++ +AA+ R + E L
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE-----L 2230
Query: 134 VQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERG-- 191
R +++ + +L+ R+ + R L +LRD D+ Q+ L ++ AE
Sbjct: 2231 FSVRVQMEEL-----SKLKARIEAENRAL---ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 192 LSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVK 251
LS + L + A +LA + L+E+ QA E R + E + + + +
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQ 2340
Query: 252 EQVAEVRAKLEEQAQQIRLQAEAFQARLKS 281
EQ ++ E+ AQQ+ + + FQ L++
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Score = 48.1 bits (113), Expect = 1e-05
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 47/286 (16%)
Query: 21 EQAVETEPEPELR-QQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR 79
EQA + + + E R Q S E G D LR QV+EE+L+ + + E
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ----RRQVEEEILALKASFEKA 1937
Query: 80 ALMDETMKELKAYKSELEEQLTPV---AEET-RARLSKELQAAQARLGADMEDVCGRLVQ 135
A A K+ELE +L + AE+T R++ EL+AA+ R A E+ R +
Sbjct: 1938 A----------AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987
Query: 136 YRGEVQAMLGQSTEELRVRLAS------------HLRKLRKRLLRDA--------DDLQK 175
R VQ L E R R A+ R+LR+R +++ + QK
Sbjct: 1988 ER--VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045
Query: 176 RLAVYQ---AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
RL + A A + E+ L ++ +++Q R A A + + R QA E
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQAR 278
++R + +RL + E+ A+ RA+ + A+++R +AE AR
Sbjct: 2106 QSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Score = 47.8 bits (112), Expect = 1e-05
Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 15/275 (5%)
Query: 7 ALLVTFLAGCQAKVEQAVE-----TEPEPELR--QQTEWQSGQRWELALGRFWDYLRWVQ 59
AL +F K E +E + E LR +Q E ++ ++ +LA + R +
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA----EEERRRR 1984
Query: 60 TLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQ 119
E+VQ+ L + + R E ++ LKA E +E+ +L +AAQ
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 120 ARLGADMEDVCGRLVQYRGEVQAMLGQSTEEL-RVRLASHLRKLRKRLLRDADDLQKRLA 178
RL A+ + + Q E+Q L Q L ++R + + +A +R A
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEE 238
E AER L E Q + A + A Q RAQA E+ R ++
Sbjct: 2105 AQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA--EQAALRQKQ 2161
Query: 239 MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
++ + EQ +A++E++ +RLQ E
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Score = 37.4 bits (85), Expect = 0.018
Identities = 55/258 (21%), Positives = 114/258 (44%), Gaps = 9/258 (3%)
Query: 61 LSEQVQEELLSSQVTQELRALM--DETMKELKAYKSELEEQL--TPVAEETRARLSKELQ 116
L + E L +V + RA +E + + E+ E+L T +A + + L + L+
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ + D E + + + E + L Q + L+++ +++LL++ LQ+
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
+ + ER + + +L L + +A + Q Q++ + +RL A M
Sbjct: 2495 FLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASM 2552
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAG 296
EE R + + V+ + E++ +++ QQ L AE Q RL+ + L+E+ R
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RLREQLQ-LLEEQHRAALA 2610
Query: 297 LVEKVQAAVGTSAAPVPS 314
E+V A+ + +P+
Sbjct: 2611 HSEEVTASQVAATKTLPN 2628
Score = 35.4 bits (80), Expect = 0.067
Identities = 77/313 (24%), Positives = 125/313 (39%), Gaps = 38/313 (12%)
Query: 17 QAKVEQAVE-TEPEPE--------LRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQE 67
Q K QAV T PE E LR Q E Q + D LR Q + E++Q+
Sbjct: 1111 QLKEAQAVPATLPELEATKASLKKLRAQAEAQ-----QPTFDALRDELRGAQEVGERLQQ 1165
Query: 68 ELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR---LGA 124
V E+ + + L+ +++ L + T V + +L ++L+ + LGA
Sbjct: 1166 RHGERDV--EVERWRERVAQLLERWQAVLAQ--TDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 125 DMEDVCGRLVQYRGEVQAMLGQSTEELRVRLA------------SHLRKLRKRLLRDADD 172
++D R Q + A E+LR A ++ K+ + D
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1281
Query: 173 LQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
+ +L Y+A A + V Q V T S + + E L
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 292
R RMEE + E +E++AEV A LE+Q Q A+A +A+ + + L + MQ
Sbjct: 1342 R-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA-KAQAEREAKELQQRMQE 1399
Query: 293 QWAGLVEKVQAAV 305
+ +V + +AAV
Sbjct: 1400 E---VVRREEAAV 1409
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 56.2 bits (134), Expect = 4e-08
Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 17 QAKVE-QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVT 75
QA+ E Q E E E R + E Q+ ++ ELA ++++++ ++ T
Sbjct: 1663 QAEAEKQKEEAEREARRRGKAEEQAVRQRELA--------------EQELEKQRQLAEGT 1708
Query: 76 QELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ R ++ + L+A ++E EQ + EE ARL +E AA Q
Sbjct: 1709 AQQRLAAEQELIRLRA-ETEQGEQQRQLLEEELARLQREAAAA---------------TQ 1752
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGA-REGAERG--L 192
R E++A L + E+ V LAS R + R + K+ +AG RE AE L
Sbjct: 1753 KRQELEAELAKVRAEMEVLLASKARAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARL 1810
Query: 193 SAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARME-EMGSRTRD----RL 247
A+ E + AA + A + L E+ A GE R + E E+ + ++ RL
Sbjct: 1811 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1870
Query: 248 DEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEP-------LVEDMQRQWAGLVEK 300
+ E A R +LEEQA Q + E A+L+ + LVED RQ + E+
Sbjct: 1871 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1930
Query: 301 VQA 303
+ A
Sbjct: 1931 ILA 1933
Score = 55.1 bits (131), Expect = 8e-08
Identities = 65/245 (26%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 56 RWVQTLSEQVQEELLSSQ-----VTQELRALMDETMKELKAYKSELEEQL--TPVAEETR 108
R + L +++QEE++ + Q+ R++ +E + ++ ++E++ + AE +R
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 109 ARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTE-ELRVRLASHLRKLRKRLL 167
R+ +E++ + +L A G GE+QA+ ++ E E + R A + +R +
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGA----EGELQALRARAEEAEAQKRQAQEEAERLRRQV 1507
Query: 168 RDADDLQKRLAVYQAGAREGAE--------RGLSAIRE-RLGPLVEQGRVRAATVG---- 214
+D + +KR A + +R AE R L A+ E RL + R+R A V
Sbjct: 1508 QD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566
Query: 215 -SLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
+A + Q A+A + RA E ++ L E VA++R + E +AQQ QAE
Sbjct: 1567 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAE 1623
Query: 274 AFQAR 278
A +AR
Sbjct: 1624 AERAR 1628
Score = 52.0 bits (123), Expect = 7e-07
Identities = 81/294 (27%), Positives = 128/294 (43%), Gaps = 33/294 (11%)
Query: 14 AGCQAKVEQA-VETEPEPELRQQTEWQSGQRWELALGRFWDYLRWV-QTLSE--QVQEEL 69
A QA E+ E E E R Q E + ++ + A + ++ QTL + QV++EL
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2192
Query: 70 ----LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEE---TRARLSKELQAAQARL 122
L + T + L+DE ++ LKA +E Q + V EE R ++ +EL +AR+
Sbjct: 2193 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-EELSKLKARI 2251
Query: 123 GADM-------EDVCGRLVQYRGEVQAMLGQSTEELRV--RLASHLRKLRKRLLRD---- 169
A+ +D R +Q E + + L V + A+ LR+L + L
Sbjct: 2252 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311
Query: 170 -ADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L++++ Q R AE L ++ L EQ R R Q L E Q +
Sbjct: 2312 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQAR-RLQEDKEQMAQQLAEETQGF 2368
Query: 229 GERL---RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL 279
L R R EM S +RL +++ +A+ EE AQ+ R QAE +L
Sbjct: 2369 QRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Score = 50.1 bits (118), Expect = 3e-06
Identities = 69/270 (25%), Positives = 119/270 (44%), Gaps = 30/270 (11%)
Query: 63 EQVQEELLSSQVTQELRALMDETMKEL-KAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
E Q L Q Q +A ++E + +L KA SELE Q V + R R ++++
Sbjct: 1877 EAFQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQR--RQVEEEILA 1933
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLL--------RDADD- 172
L A E + E+ + + + LR + + L R+R L R+A++
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993
Query: 173 LQKRLAVYQAGAR------EGAERGLSAIRE--RLGPLVEQGRVRAATVGSLAGQP---L 221
+QK LA + AR E ER + + E RL EQ R + A Q
Sbjct: 1994 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2053
Query: 222 QERAQAWG-ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
+E+A A+ ++ +++ + + LD+++ + AE + E+A++ R+QAE A+ +
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSR 2112
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAAVGTSAA 310
VE+ +R E+ QA AA
Sbjct: 2113 R----QVEEAERLKQSAEEQAQARAQAQAA 2138
Score = 48.9 bits (115), Expect = 6e-06
Identities = 62/243 (25%), Positives = 106/243 (43%), Gaps = 38/243 (15%)
Query: 54 YLRWV-QTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLS 112
Y++++ +TL +EE L+ Q E R + E L E + QL + +A+
Sbjct: 1337 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQAE 1391
Query: 113 KELQAAQARLGADM---EDVCGRLVQYRGEVQA---MLGQSTE---ELRVRLASHLRKLR 163
+E + Q R+ ++ E+ Q + +Q L QS+E + + R A + R
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 164 KRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 223
R+ + ++ +L + R GAE L A+R R Q R
Sbjct: 1452 LRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKR---------------- 1494
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQV-AEVRAKLEEQA-----QQIRLQAEAFQA 277
+AQ ERLR ++++ R R E+ +V AE A E+Q +++RLQAE +
Sbjct: 1495 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1554
Query: 278 RLK 280
RL+
Sbjct: 1555 RLR 1557
Score = 48.9 bits (115), Expect = 6e-06
Identities = 58/270 (21%), Positives = 120/270 (44%), Gaps = 26/270 (9%)
Query: 14 AGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQ 73
A +A+ + A E +LR++ E ++ +R + LR Q ++++ ++
Sbjct: 2129 AQARAQAQAAAE-----KLRKEAEQEAARRAQAEQAA----LRQKQAADAEMEKHKKFAE 2179
Query: 74 VTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRL 133
T +A +++ + L+ E + Q + EE + ++ +AA+ R + E L
Sbjct: 2180 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE-----L 2234
Query: 134 VQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERG-- 191
R +++ + +L+ R+ + R L +LRD D+ Q+ L ++ AE
Sbjct: 2235 FSVRVQMEEL-----SKLKARIEAENRAL---ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 192 LSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVK 251
LS + L + A +LA + L+E+ QA E R + E + + + +
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQ 2344
Query: 252 EQVAEVRAKLEEQAQQIRLQAEAFQARLKS 281
EQ ++ E+ AQQ+ + + FQ L++
Sbjct: 2345 EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Score = 48.1 bits (113), Expect = 1e-05
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 47/286 (16%)
Query: 21 EQAVETEPEPELR-QQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR 79
EQA + + + E R Q S E G D LR QV+EE+L+ + + E
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ----RRQVEEEILALKASFEKA 1941
Query: 80 ALMDETMKELKAYKSELEEQLTPV---AEET-RARLSKELQAAQARLGADMEDVCGRLVQ 135
A A K+ELE +L + AE+T R++ EL+AA+ R A E+ R +
Sbjct: 1942 A----------AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1991
Query: 136 YRGEVQAMLGQSTEELRVRLAS------------HLRKLRKRLLRDA--------DDLQK 175
R VQ L E R R A+ R+LR+R +++ + QK
Sbjct: 1992 ER--VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2049
Query: 176 RLAVYQ---AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
RL + A A + E+ L ++ +++Q R A A + + R QA E
Sbjct: 2050 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2109
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQAR 278
++R + +RL + E+ A+ RA+ + A+++R +AE AR
Sbjct: 2110 QSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2152
Score = 47.8 bits (112), Expect = 1e-05
Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 15/275 (5%)
Query: 7 ALLVTFLAGCQAKVEQAVE-----TEPEPELR--QQTEWQSGQRWELALGRFWDYLRWVQ 59
AL +F K E +E + E LR +Q E ++ ++ +LA + R +
Sbjct: 1933 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA----EEERRRR 1988
Query: 60 TLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQ 119
E+VQ+ L + + R E ++ LKA E +E+ +L +AAQ
Sbjct: 1989 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2048
Query: 120 ARLGADMEDVCGRLVQYRGEVQAMLGQSTEEL-RVRLASHLRKLRKRLLRDADDLQKRLA 178
RL A+ + + Q E+Q L Q L ++R + + +A +R A
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2108
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEE 238
E AER L E Q + A + A Q RAQA E+ R ++
Sbjct: 2109 AQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA--EQAALRQKQ 2165
Query: 239 MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
++ + EQ +A++E++ +RLQ E
Sbjct: 2166 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2200
Score = 37.4 bits (85), Expect = 0.018
Identities = 55/258 (21%), Positives = 114/258 (44%), Gaps = 9/258 (3%)
Query: 61 LSEQVQEELLSSQVTQELRALM--DETMKELKAYKSELEEQL--TPVAEETRARLSKELQ 116
L + E L +V + RA +E + + E+ E+L T +A + + L + L+
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2439
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ + D E + + + E + L Q + L+++ +++LL++ LQ+
Sbjct: 2440 IQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2498
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
+ + ER + + +L L + +A + Q Q++ + +RL A M
Sbjct: 2499 FLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASM 2556
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAG 296
EE R + + V+ + E++ +++ QQ L AE Q RL+ + L+E+ R
Sbjct: 2557 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RLREQLQ-LLEEQHRAALA 2614
Query: 297 LVEKVQAAVGTSAAPVPS 314
E+V A+ + +P+
Sbjct: 2615 HSEEVTASQVAATKTLPN 2632
Score = 35.4 bits (80), Expect = 0.067
Identities = 77/313 (24%), Positives = 125/313 (39%), Gaps = 38/313 (12%)
Query: 17 QAKVEQAVE-TEPEPE--------LRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQE 67
Q K QAV T PE E LR Q E Q + D LR Q + E++Q+
Sbjct: 1115 QLKEAQAVPATLPELEATKASLKKLRAQAEAQ-----QPTFDALRDELRGAQEVGERLQQ 1169
Query: 68 ELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR---LGA 124
V E+ + + L+ +++ L + T V + +L ++L+ + LGA
Sbjct: 1170 RHGERDV--EVERWRERVAQLLERWQAVLAQ--TDVRQRELEQLGRQLRYYRESADPLGA 1225
Query: 125 DMEDVCGRLVQYRGEVQAMLGQSTEELRVRLA------------SHLRKLRKRLLRDADD 172
++D R Q + A E+LR A ++ K+ + D
Sbjct: 1226 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1285
Query: 173 LQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
+ +L Y+A A + V Q V T S + + E L
Sbjct: 1286 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1345
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 292
R RMEE + E +E++AEV A LE+Q Q A+A +A+ + + L + MQ
Sbjct: 1346 R-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA-KAQAEREAKELQQRMQE 1403
Query: 293 QWAGLVEKVQAAV 305
+ +V + +AAV
Sbjct: 1404 E---VVRREEAAV 1413
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 56.2 bits (134), Expect = 4e-08
Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 17 QAKVE-QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVT 75
QA+ E Q E E E R + E Q+ ++ ELA ++++++ ++ T
Sbjct: 1659 QAEAEKQKEEAEREARRRGKAEEQAVRQRELA--------------EQELEKQRQLAEGT 1704
Query: 76 QELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ R ++ + L+A ++E EQ + EE ARL +E AA Q
Sbjct: 1705 AQQRLAAEQELIRLRA-ETEQGEQQRQLLEEELARLQREAAAA---------------TQ 1748
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGA-REGAERG--L 192
R E++A L + E+ V LAS R + R + K+ +AG RE AE L
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Query: 193 SAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARME-EMGSRTRD----RL 247
A+ E + AA + A + L E+ A GE R + E E+ + ++ RL
Sbjct: 1807 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1866
Query: 248 DEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEP-------LVEDMQRQWAGLVEK 300
+ E A R +LEEQA Q + E A+L+ + LVED RQ + E+
Sbjct: 1867 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1926
Query: 301 VQA 303
+ A
Sbjct: 1927 ILA 1929
Score = 55.1 bits (131), Expect = 8e-08
Identities = 65/245 (26%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 56 RWVQTLSEQVQEELLSSQ-----VTQELRALMDETMKELKAYKSELEEQL--TPVAEETR 108
R + L +++QEE++ + Q+ R++ +E + ++ ++E++ + AE +R
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 109 ARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTE-ELRVRLASHLRKLRKRLL 167
R+ +E++ + +L A G GE+QA+ ++ E E + R A + +R +
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGA----EGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 168 RDADDLQKRLAVYQAGAREGAE--------RGLSAIRE-RLGPLVEQGRVRAATVG---- 214
+D + +KR A + +R AE R L A+ E RL + R+R A V
Sbjct: 1504 QD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 215 -SLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
+A + Q A+A + RA E ++ L E VA++R + E +AQQ QAE
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAE 1619
Query: 274 AFQAR 278
A +AR
Sbjct: 1620 AERAR 1624
Score = 52.0 bits (123), Expect = 7e-07
Identities = 81/294 (27%), Positives = 128/294 (43%), Gaps = 33/294 (11%)
Query: 14 AGCQAKVEQA-VETEPEPELRQQTEWQSGQRWELALGRFWDYLRWV-QTLSE--QVQEEL 69
A QA E+ E E E R Q E + ++ + A + ++ QTL + QV++EL
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 70 ----LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEE---TRARLSKELQAAQARL 122
L + T + L+DE ++ LKA +E Q + V EE R ++ +EL +AR+
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-EELSKLKARI 2247
Query: 123 GADM-------EDVCGRLVQYRGEVQAMLGQSTEELRV--RLASHLRKLRKRLLRD---- 169
A+ +D R +Q E + + L V + A+ LR+L + L
Sbjct: 2248 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 170 -ADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L++++ Q R AE L ++ L EQ R R Q L E Q +
Sbjct: 2308 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQAR-RLQEDKEQMAQQLAEETQGF 2364
Query: 229 GERL---RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL 279
L R R EM S +RL +++ +A+ EE AQ+ R QAE +L
Sbjct: 2365 QRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Score = 50.1 bits (118), Expect = 3e-06
Identities = 69/270 (25%), Positives = 119/270 (44%), Gaps = 30/270 (11%)
Query: 63 EQVQEELLSSQVTQELRALMDETMKEL-KAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
E Q L Q Q +A ++E + +L KA SELE Q V + R R ++++
Sbjct: 1873 EAFQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQR--RQVEEEILA 1929
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLL--------RDADD- 172
L A E + E+ + + + LR + + L R+R L R+A++
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 173 LQKRLAVYQAGAR------EGAERGLSAIRE--RLGPLVEQGRVRAATVGSLAGQP---L 221
+QK LA + AR E ER + + E RL EQ R + A Q
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 222 QERAQAWG-ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
+E+A A+ ++ +++ + + LD+++ + AE + E+A++ R+QAE A+ +
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAAVGTSAA 310
VE+ +R E+ QA AA
Sbjct: 2109 R----QVEEAERLKQSAEEQAQARAQAQAA 2134
Score = 48.9 bits (115), Expect = 6e-06
Identities = 62/243 (25%), Positives = 106/243 (43%), Gaps = 38/243 (15%)
Query: 54 YLRWV-QTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLS 112
Y++++ +TL +EE L+ Q E R + E L E + QL + +A+
Sbjct: 1333 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQAE 1387
Query: 113 KELQAAQARLGADM---EDVCGRLVQYRGEVQA---MLGQSTE---ELRVRLASHLRKLR 163
+E + Q R+ ++ E+ Q + +Q L QS+E + + R A + R
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 164 KRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 223
R+ + ++ +L + R GAE L A+R R Q R
Sbjct: 1448 LRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKR---------------- 1490
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQV-AEVRAKLEEQA-----QQIRLQAEAFQA 277
+AQ ERLR ++++ R R E+ +V AE A E+Q +++RLQAE +
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1550
Query: 278 RLK 280
RL+
Sbjct: 1551 RLR 1553
Score = 48.9 bits (115), Expect = 6e-06
Identities = 58/270 (21%), Positives = 120/270 (44%), Gaps = 26/270 (9%)
Query: 14 AGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQ 73
A +A+ + A E +LR++ E ++ +R + LR Q ++++ ++
Sbjct: 2125 AQARAQAQAAAE-----KLRKEAEQEAARRAQAEQAA----LRQKQAADAEMEKHKKFAE 2175
Query: 74 VTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRL 133
T +A +++ + L+ E + Q + EE + ++ +AA+ R + E L
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE-----L 2230
Query: 134 VQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERG-- 191
R +++ + +L+ R+ + R L +LRD D+ Q+ L ++ AE
Sbjct: 2231 FSVRVQMEEL-----SKLKARIEAENRAL---ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 192 LSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVK 251
LS + L + A +LA + L+E+ QA E R + E + + + +
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQ 2340
Query: 252 EQVAEVRAKLEEQAQQIRLQAEAFQARLKS 281
EQ ++ E+ AQQ+ + + FQ L++
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Score = 48.1 bits (113), Expect = 1e-05
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 47/286 (16%)
Query: 21 EQAVETEPEPELR-QQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR 79
EQA + + + E R Q S E G D LR QV+EE+L+ + + E
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ----RRQVEEEILALKASFEKA 1937
Query: 80 ALMDETMKELKAYKSELEEQLTPV---AEET-RARLSKELQAAQARLGADMEDVCGRLVQ 135
A A K+ELE +L + AE+T R++ EL+AA+ R A E+ R +
Sbjct: 1938 A----------AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1987
Query: 136 YRGEVQAMLGQSTEELRVRLAS------------HLRKLRKRLLRDA--------DDLQK 175
R VQ L E R R A+ R+LR+R +++ + QK
Sbjct: 1988 ER--VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045
Query: 176 RLAVYQ---AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
RL + A A + E+ L ++ +++Q R A A + + R QA E
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQAR 278
++R + +RL + E+ A+ RA+ + A+++R +AE AR
Sbjct: 2106 QSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2148
Score = 47.8 bits (112), Expect = 1e-05
Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 15/275 (5%)
Query: 7 ALLVTFLAGCQAKVEQAVE-----TEPEPELR--QQTEWQSGQRWELALGRFWDYLRWVQ 59
AL +F K E +E + E LR +Q E ++ ++ +LA + R +
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA----EEERRRR 1984
Query: 60 TLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQ 119
E+VQ+ L + + R E ++ LKA E +E+ +L +AAQ
Sbjct: 1985 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 120 ARLGADMEDVCGRLVQYRGEVQAMLGQSTEEL-RVRLASHLRKLRKRLLRDADDLQKRLA 178
RL A+ + + Q E+Q L Q L ++R + + +A +R A
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEE 238
E AER L E Q + A + A Q RAQA E+ R ++
Sbjct: 2105 AQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA--EQAALRQKQ 2161
Query: 239 MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
++ + EQ +A++E++ +RLQ E
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196
Score = 37.4 bits (85), Expect = 0.018
Identities = 55/258 (21%), Positives = 114/258 (44%), Gaps = 9/258 (3%)
Query: 61 LSEQVQEELLSSQVTQELRALM--DETMKELKAYKSELEEQL--TPVAEETRARLSKELQ 116
L + E L +V + RA +E + + E+ E+L T +A + + L + L+
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2435
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ + D E + + + E + L Q + L+++ +++LL++ LQ+
Sbjct: 2436 IQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
+ + ER + + +L L + +A + Q Q++ + +RL A M
Sbjct: 2495 FLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASM 2552
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAG 296
EE R + + V+ + E++ +++ QQ L AE Q RL+ + L+E+ R
Sbjct: 2553 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RLREQLQ-LLEEQHRAALA 2610
Query: 297 LVEKVQAAVGTSAAPVPS 314
E+V A+ + +P+
Sbjct: 2611 HSEEVTASQVAATKTLPN 2628
Score = 35.4 bits (80), Expect = 0.067
Identities = 77/313 (24%), Positives = 125/313 (39%), Gaps = 38/313 (12%)
Query: 17 QAKVEQAVE-TEPEPE--------LRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQE 67
Q K QAV T PE E LR Q E Q + D LR Q + E++Q+
Sbjct: 1111 QLKEAQAVPATLPELEATKASLKKLRAQAEAQ-----QPTFDALRDELRGAQEVGERLQQ 1165
Query: 68 ELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR---LGA 124
V E+ + + L+ +++ L + T V + +L ++L+ + LGA
Sbjct: 1166 RHGERDV--EVERWRERVAQLLERWQAVLAQ--TDVRQRELEQLGRQLRYYRESADPLGA 1221
Query: 125 DMEDVCGRLVQYRGEVQAMLGQSTEELRVRLA------------SHLRKLRKRLLRDADD 172
++D R Q + A E+LR A ++ K+ + D
Sbjct: 1222 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1281
Query: 173 LQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
+ +L Y+A A + V Q V T S + + E L
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 292
R RMEE + E +E++AEV A LE+Q Q A+A +A+ + + L + MQ
Sbjct: 1342 R-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA-KAQAEREAKELQQRMQE 1399
Query: 293 QWAGLVEKVQAAV 305
+ +V + +AAV
Sbjct: 1400 E---VVRREEAAV 1409
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 56.2 bits (134), Expect = 4e-08
Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 17 QAKVE-QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVT 75
QA+ E Q E E E R + E Q+ ++ ELA ++++++ ++ T
Sbjct: 1627 QAEAEKQKEEAEREARRRGKAEEQAVRQRELA--------------EQELEKQRQLAEGT 1672
Query: 76 QELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ R ++ + L+A ++E EQ + EE ARL +E AA Q
Sbjct: 1673 AQQRLAAEQELIRLRA-ETEQGEQQRQLLEEELARLQREAAAA---------------TQ 1716
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGA-REGAERG--L 192
R E++A L + E+ V LAS R + R + K+ +AG RE AE L
Sbjct: 1717 KRQELEAELAKVRAEMEVLLASKARAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARL 1774
Query: 193 SAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARME-EMGSRTRD----RL 247
A+ E + AA + A + L E+ A GE R + E E+ + ++ RL
Sbjct: 1775 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1834
Query: 248 DEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEP-------LVEDMQRQWAGLVEK 300
+ E A R +LEEQA Q + E A+L+ + LVED RQ + E+
Sbjct: 1835 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1894
Query: 301 VQA 303
+ A
Sbjct: 1895 ILA 1897
Score = 55.1 bits (131), Expect = 8e-08
Identities = 65/245 (26%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 56 RWVQTLSEQVQEELLSSQ-----VTQELRALMDETMKELKAYKSELEEQL--TPVAEETR 108
R + L +++QEE++ + Q+ R++ +E + ++ ++E++ + AE +R
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415
Query: 109 ARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTE-ELRVRLASHLRKLRKRLL 167
R+ +E++ + +L A G GE+QA+ ++ E E + R A + +R +
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGA----EGELQALRARAEEAEAQKRQAQEEAERLRRQV 1471
Query: 168 RDADDLQKRLAVYQAGAREGAE--------RGLSAIRE-RLGPLVEQGRVRAATVG---- 214
+D + +KR A + +R AE R L A+ E RL + R+R A V
Sbjct: 1472 QD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1530
Query: 215 -SLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
+A + Q A+A + RA E ++ L E VA++R + E +AQQ QAE
Sbjct: 1531 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAE 1587
Query: 274 AFQAR 278
A +AR
Sbjct: 1588 AERAR 1592
Score = 52.0 bits (123), Expect = 7e-07
Identities = 81/294 (27%), Positives = 128/294 (43%), Gaps = 33/294 (11%)
Query: 14 AGCQAKVEQA-VETEPEPELRQQTEWQSGQRWELALGRFWDYLRWV-QTLSE--QVQEEL 69
A QA E+ E E E R Q E + ++ + A + ++ QTL + QV++EL
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2156
Query: 70 ----LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEE---TRARLSKELQAAQARL 122
L + T + L+DE ++ LKA +E Q + V EE R ++ +EL +AR+
Sbjct: 2157 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-EELSKLKARI 2215
Query: 123 GADM-------EDVCGRLVQYRGEVQAMLGQSTEELRV--RLASHLRKLRKRLLRD---- 169
A+ +D R +Q E + + L V + A+ LR+L + L
Sbjct: 2216 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275
Query: 170 -ADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L++++ Q R AE L ++ L EQ R R Q L E Q +
Sbjct: 2276 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQAR-RLQEDKEQMAQQLAEETQGF 2332
Query: 229 GERL---RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL 279
L R R EM S +RL +++ +A+ EE AQ+ R QAE +L
Sbjct: 2333 QRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Score = 50.1 bits (118), Expect = 3e-06
Identities = 69/270 (25%), Positives = 119/270 (44%), Gaps = 30/270 (11%)
Query: 63 EQVQEELLSSQVTQELRALMDETMKEL-KAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
E Q L Q Q +A ++E + +L KA SELE Q V + R R ++++
Sbjct: 1841 EAFQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQR--RQVEEEILA 1897
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLL--------RDADD- 172
L A E + E+ + + + LR + + L R+R L R+A++
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957
Query: 173 LQKRLAVYQAGAR------EGAERGLSAIRE--RLGPLVEQGRVRAATVGSLAGQP---L 221
+QK LA + AR E ER + + E RL EQ R + A Q
Sbjct: 1958 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2017
Query: 222 QERAQAWG-ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
+E+A A+ ++ +++ + + LD+++ + AE + E+A++ R+QAE A+ +
Sbjct: 2018 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSR 2076
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAAVGTSAA 310
VE+ +R E+ QA AA
Sbjct: 2077 R----QVEEAERLKQSAEEQAQARAQAQAA 2102
Score = 48.9 bits (115), Expect = 6e-06
Identities = 62/243 (25%), Positives = 106/243 (43%), Gaps = 38/243 (15%)
Query: 54 YLRWV-QTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLS 112
Y++++ +TL +EE L+ Q E R + E L E + QL + +A+
Sbjct: 1301 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQAE 1355
Query: 113 KELQAAQARLGADM---EDVCGRLVQYRGEVQA---MLGQSTE---ELRVRLASHLRKLR 163
+E + Q R+ ++ E+ Q + +Q L QS+E + + R A + R
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415
Query: 164 KRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 223
R+ + ++ +L + R GAE L A+R R Q R
Sbjct: 1416 LRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKR---------------- 1458
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQV-AEVRAKLEEQA-----QQIRLQAEAFQA 277
+AQ ERLR ++++ R R E+ +V AE A E+Q +++RLQAE +
Sbjct: 1459 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1518
Query: 278 RLK 280
RL+
Sbjct: 1519 RLR 1521
Score = 48.9 bits (115), Expect = 6e-06
Identities = 58/270 (21%), Positives = 120/270 (44%), Gaps = 26/270 (9%)
Query: 14 AGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQ 73
A +A+ + A E +LR++ E ++ +R + LR Q ++++ ++
Sbjct: 2093 AQARAQAQAAAE-----KLRKEAEQEAARRAQAEQAA----LRQKQAADAEMEKHKKFAE 2143
Query: 74 VTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRL 133
T +A +++ + L+ E + Q + EE + ++ +AA+ R + E L
Sbjct: 2144 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE-----L 2198
Query: 134 VQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERG-- 191
R +++ + +L+ R+ + R L +LRD D+ Q+ L ++ AE
Sbjct: 2199 FSVRVQMEEL-----SKLKARIEAENRAL---ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2250
Query: 192 LSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVK 251
LS + L + A +LA + L+E+ QA E R + E + + + +
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQ 2308
Query: 252 EQVAEVRAKLEEQAQQIRLQAEAFQARLKS 281
EQ ++ E+ AQQ+ + + FQ L++
Sbjct: 2309 EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Score = 48.1 bits (113), Expect = 1e-05
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 47/286 (16%)
Query: 21 EQAVETEPEPELR-QQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR 79
EQA + + + E R Q S E G D LR QV+EE+L+ + + E
Sbjct: 1850 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ----RRQVEEEILALKASFEKA 1905
Query: 80 ALMDETMKELKAYKSELEEQLTPV---AEET-RARLSKELQAAQARLGADMEDVCGRLVQ 135
A A K+ELE +L + AE+T R++ EL+AA+ R A E+ R +
Sbjct: 1906 A----------AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1955
Query: 136 YRGEVQAMLGQSTEELRVRLAS------------HLRKLRKRLLRDA--------DDLQK 175
R VQ L E R R A+ R+LR+R +++ + QK
Sbjct: 1956 ER--VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2013
Query: 176 RLAVYQ---AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
RL + A A + E+ L ++ +++Q R A A + + R QA E
Sbjct: 2014 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2073
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQAR 278
++R + +RL + E+ A+ RA+ + A+++R +AE AR
Sbjct: 2074 QSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2116
Score = 47.8 bits (112), Expect = 1e-05
Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 15/275 (5%)
Query: 7 ALLVTFLAGCQAKVEQAVE-----TEPEPELR--QQTEWQSGQRWELALGRFWDYLRWVQ 59
AL +F K E +E + E LR +Q E ++ ++ +LA + R +
Sbjct: 1897 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA----EEERRRR 1952
Query: 60 TLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQ 119
E+VQ+ L + + R E ++ LKA E +E+ +L +AAQ
Sbjct: 1953 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2012
Query: 120 ARLGADMEDVCGRLVQYRGEVQAMLGQSTEEL-RVRLASHLRKLRKRLLRDADDLQKRLA 178
RL A+ + + Q E+Q L Q L ++R + + +A +R A
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2072
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEE 238
E AER L E Q + A + A Q RAQA E+ R ++
Sbjct: 2073 AQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA--EQAALRQKQ 2129
Query: 239 MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
++ + EQ +A++E++ +RLQ E
Sbjct: 2130 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2164
Score = 37.4 bits (85), Expect = 0.018
Identities = 55/258 (21%), Positives = 114/258 (44%), Gaps = 9/258 (3%)
Query: 61 LSEQVQEELLSSQVTQELRALM--DETMKELKAYKSELEEQL--TPVAEETRARLSKELQ 116
L + E L +V + RA +E + + E+ E+L T +A + + L + L+
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2403
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ + D E + + + E + L Q + L+++ +++LL++ LQ+
Sbjct: 2404 IQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2462
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
+ + ER + + +L L + +A + Q Q++ + +RL A M
Sbjct: 2463 FLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASM 2520
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAG 296
EE R + + V+ + E++ +++ QQ L AE Q RL+ + L+E+ R
Sbjct: 2521 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RLREQLQ-LLEEQHRAALA 2578
Query: 297 LVEKVQAAVGTSAAPVPS 314
E+V A+ + +P+
Sbjct: 2579 HSEEVTASQVAATKTLPN 2596
Score = 35.4 bits (80), Expect = 0.067
Identities = 77/313 (24%), Positives = 125/313 (39%), Gaps = 38/313 (12%)
Query: 17 QAKVEQAVE-TEPEPE--------LRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQE 67
Q K QAV T PE E LR Q E Q + D LR Q + E++Q+
Sbjct: 1079 QLKEAQAVPATLPELEATKASLKKLRAQAEAQ-----QPTFDALRDELRGAQEVGERLQQ 1133
Query: 68 ELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR---LGA 124
V E+ + + L+ +++ L + T V + +L ++L+ + LGA
Sbjct: 1134 RHGERDV--EVERWRERVAQLLERWQAVLAQ--TDVRQRELEQLGRQLRYYRESADPLGA 1189
Query: 125 DMEDVCGRLVQYRGEVQAMLGQSTEELRVRLA------------SHLRKLRKRLLRDADD 172
++D R Q + A E+LR A ++ K+ + D
Sbjct: 1190 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1249
Query: 173 LQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
+ +L Y+A A + V Q V T S + + E L
Sbjct: 1250 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1309
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 292
R RMEE + E +E++AEV A LE+Q Q A+A +A+ + + L + MQ
Sbjct: 1310 R-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA-KAQAEREAKELQQRMQE 1367
Query: 293 QWAGLVEKVQAAV 305
+ +V + +AAV
Sbjct: 1368 E---VVRREEAAV 1377
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 56.2 bits (134), Expect = 4e-08
Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 17 QAKVE-QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVT 75
QA+ E Q E E E R + E Q+ ++ ELA ++++++ ++ T
Sbjct: 1796 QAEAEKQKEEAEREARRRGKAEEQAVRQRELA--------------EQELEKQRQLAEGT 1841
Query: 76 QELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ R ++ + L+A ++E EQ + EE ARL +E AA Q
Sbjct: 1842 AQQRLAAEQELIRLRA-ETEQGEQQRQLLEEELARLQREAAAA---------------TQ 1885
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGA-REGAERG--L 192
R E++A L + E+ V LAS R + R + K+ +AG RE AE L
Sbjct: 1886 KRQELEAELAKVRAEMEVLLASKARAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARL 1943
Query: 193 SAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARME-EMGSRTRD----RL 247
A+ E + AA + A + L E+ A GE R + E E+ + ++ RL
Sbjct: 1944 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 2003
Query: 248 DEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEP-------LVEDMQRQWAGLVEK 300
+ E A R +LEEQA Q + E A+L+ + LVED RQ + E+
Sbjct: 2004 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 2063
Query: 301 VQA 303
+ A
Sbjct: 2064 ILA 2066
Score = 55.1 bits (131), Expect = 8e-08
Identities = 65/245 (26%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 56 RWVQTLSEQVQEELLSSQ-----VTQELRALMDETMKELKAYKSELEEQL--TPVAEETR 108
R + L +++QEE++ + Q+ R++ +E + ++ ++E++ + AE +R
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584
Query: 109 ARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTE-ELRVRLASHLRKLRKRLL 167
R+ +E++ + +L A G GE+QA+ ++ E E + R A + +R +
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGA----EGELQALRARAEEAEAQKRQAQEEAERLRRQV 1640
Query: 168 RDADDLQKRLAVYQAGAREGAE--------RGLSAIRE-RLGPLVEQGRVRAATVG---- 214
+D + +KR A + +R AE R L A+ E RL + R+R A V
Sbjct: 1641 QD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1699
Query: 215 -SLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
+A + Q A+A + RA E ++ L E VA++R + E +AQQ QAE
Sbjct: 1700 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAE 1756
Query: 274 AFQAR 278
A +AR
Sbjct: 1757 AERAR 1761
Score = 52.0 bits (123), Expect = 7e-07
Identities = 81/294 (27%), Positives = 128/294 (43%), Gaps = 33/294 (11%)
Query: 14 AGCQAKVEQA-VETEPEPELRQQTEWQSGQRWELALGRFWDYLRWV-QTLSE--QVQEEL 69
A QA E+ E E E R Q E + ++ + A + ++ QTL + QV++EL
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2325
Query: 70 ----LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEE---TRARLSKELQAAQARL 122
L + T + L+DE ++ LKA +E Q + V EE R ++ +EL +AR+
Sbjct: 2326 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-EELSKLKARI 2384
Query: 123 GADM-------EDVCGRLVQYRGEVQAMLGQSTEELRV--RLASHLRKLRKRLLRD---- 169
A+ +D R +Q E + + L V + A+ LR+L + L
Sbjct: 2385 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444
Query: 170 -ADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L++++ Q R AE L ++ L EQ R R Q L E Q +
Sbjct: 2445 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQAR-RLQEDKEQMAQQLAEETQGF 2501
Query: 229 GERL---RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL 279
L R R EM S +RL +++ +A+ EE AQ+ R QAE +L
Sbjct: 2502 QRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Score = 50.1 bits (118), Expect = 3e-06
Identities = 69/270 (25%), Positives = 119/270 (44%), Gaps = 30/270 (11%)
Query: 63 EQVQEELLSSQVTQELRALMDETMKEL-KAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
E Q L Q Q +A ++E + +L KA SELE Q V + R R ++++
Sbjct: 2010 EAFQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQR--RQVEEEILA 2066
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLL--------RDADD- 172
L A E + E+ + + + LR + + L R+R L R+A++
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126
Query: 173 LQKRLAVYQAGAR------EGAERGLSAIRE--RLGPLVEQGRVRAATVGSLAGQP---L 221
+QK LA + AR E ER + + E RL EQ R + A Q
Sbjct: 2127 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2186
Query: 222 QERAQAWG-ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
+E+A A+ ++ +++ + + LD+++ + AE + E+A++ R+QAE A+ +
Sbjct: 2187 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSR 2245
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAAVGTSAA 310
VE+ +R E+ QA AA
Sbjct: 2246 R----QVEEAERLKQSAEEQAQARAQAQAA 2271
Score = 48.9 bits (115), Expect = 6e-06
Identities = 62/243 (25%), Positives = 106/243 (43%), Gaps = 38/243 (15%)
Query: 54 YLRWV-QTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLS 112
Y++++ +TL +EE L+ Q E R + E L E + QL + +A+
Sbjct: 1470 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQAE 1524
Query: 113 KELQAAQARLGADM---EDVCGRLVQYRGEVQA---MLGQSTE---ELRVRLASHLRKLR 163
+E + Q R+ ++ E+ Q + +Q L QS+E + + R A + R
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584
Query: 164 KRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 223
R+ + ++ +L + R GAE L A+R R Q R
Sbjct: 1585 LRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKR---------------- 1627
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQV-AEVRAKLEEQA-----QQIRLQAEAFQA 277
+AQ ERLR ++++ R R E+ +V AE A E+Q +++RLQAE +
Sbjct: 1628 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1687
Query: 278 RLK 280
RL+
Sbjct: 1688 RLR 1690
Score = 48.9 bits (115), Expect = 6e-06
Identities = 58/270 (21%), Positives = 120/270 (44%), Gaps = 26/270 (9%)
Query: 14 AGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQ 73
A +A+ + A E +LR++ E ++ +R + LR Q ++++ ++
Sbjct: 2262 AQARAQAQAAAE-----KLRKEAEQEAARRAQAEQAA----LRQKQAADAEMEKHKKFAE 2312
Query: 74 VTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRL 133
T +A +++ + L+ E + Q + EE + ++ +AA+ R + E L
Sbjct: 2313 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE-----L 2367
Query: 134 VQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERG-- 191
R +++ + +L+ R+ + R L +LRD D+ Q+ L ++ AE
Sbjct: 2368 FSVRVQMEEL-----SKLKARIEAENRAL---ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2419
Query: 192 LSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVK 251
LS + L + A +LA + L+E+ QA E R + E + + + +
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQ 2477
Query: 252 EQVAEVRAKLEEQAQQIRLQAEAFQARLKS 281
EQ ++ E+ AQQ+ + + FQ L++
Sbjct: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Score = 48.1 bits (113), Expect = 1e-05
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 47/286 (16%)
Query: 21 EQAVETEPEPELR-QQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR 79
EQA + + + E R Q S E G D LR QV+EE+L+ + + E
Sbjct: 2019 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ----RRQVEEEILALKASFEKA 2074
Query: 80 ALMDETMKELKAYKSELEEQLTPV---AEET-RARLSKELQAAQARLGADMEDVCGRLVQ 135
A A K+ELE +L + AE+T R++ EL+AA+ R A E+ R +
Sbjct: 2075 A----------AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2124
Query: 136 YRGEVQAMLGQSTEELRVRLAS------------HLRKLRKRLLRDA--------DDLQK 175
R VQ L E R R A+ R+LR+R +++ + QK
Sbjct: 2125 ER--VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2182
Query: 176 RLAVYQ---AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
RL + A A + E+ L ++ +++Q R A A + + R QA E
Sbjct: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2242
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQAR 278
++R + +RL + E+ A+ RA+ + A+++R +AE AR
Sbjct: 2243 QSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2285
Score = 47.8 bits (112), Expect = 1e-05
Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 15/275 (5%)
Query: 7 ALLVTFLAGCQAKVEQAVE-----TEPEPELR--QQTEWQSGQRWELALGRFWDYLRWVQ 59
AL +F K E +E + E LR +Q E ++ ++ +LA + R +
Sbjct: 2066 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA----EEERRRR 2121
Query: 60 TLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQ 119
E+VQ+ L + + R E ++ LKA E +E+ +L +AAQ
Sbjct: 2122 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2181
Query: 120 ARLGADMEDVCGRLVQYRGEVQAMLGQSTEEL-RVRLASHLRKLRKRLLRDADDLQKRLA 178
RL A+ + + Q E+Q L Q L ++R + + +A +R A
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2241
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEE 238
E AER L E Q + A + A Q RAQA E+ R ++
Sbjct: 2242 AQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA--EQAALRQKQ 2298
Query: 239 MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
++ + EQ +A++E++ +RLQ E
Sbjct: 2299 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2333
Score = 37.4 bits (85), Expect = 0.018
Identities = 55/258 (21%), Positives = 114/258 (44%), Gaps = 9/258 (3%)
Query: 61 LSEQVQEELLSSQVTQELRALM--DETMKELKAYKSELEEQL--TPVAEETRARLSKELQ 116
L + E L +V + RA +E + + E+ E+L T +A + + L + L+
Sbjct: 2513 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2572
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ + D E + + + E + L Q + L+++ +++LL++ LQ+
Sbjct: 2573 IQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
+ + ER + + +L L + +A + Q Q++ + +RL A M
Sbjct: 2632 FLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASM 2689
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAG 296
EE R + + V+ + E++ +++ QQ L AE Q RL+ + L+E+ R
Sbjct: 2690 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RLREQLQ-LLEEQHRAALA 2747
Query: 297 LVEKVQAAVGTSAAPVPS 314
E+V A+ + +P+
Sbjct: 2748 HSEEVTASQVAATKTLPN 2765
Score = 35.4 bits (80), Expect = 0.067
Identities = 77/313 (24%), Positives = 125/313 (39%), Gaps = 38/313 (12%)
Query: 17 QAKVEQAVE-TEPEPE--------LRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQE 67
Q K QAV T PE E LR Q E Q + D LR Q + E++Q+
Sbjct: 1248 QLKEAQAVPATLPELEATKASLKKLRAQAEAQ-----QPTFDALRDELRGAQEVGERLQQ 1302
Query: 68 ELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR---LGA 124
V E+ + + L+ +++ L + T V + +L ++L+ + LGA
Sbjct: 1303 RHGERDV--EVERWRERVAQLLERWQAVLAQ--TDVRQRELEQLGRQLRYYRESADPLGA 1358
Query: 125 DMEDVCGRLVQYRGEVQAMLGQSTEELRVRLA------------SHLRKLRKRLLRDADD 172
++D R Q + A E+LR A ++ K+ + D
Sbjct: 1359 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1418
Query: 173 LQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
+ +L Y+A A + V Q V T S + + E L
Sbjct: 1419 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1478
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 292
R RMEE + E +E++AEV A LE+Q Q A+A +A+ + + L + MQ
Sbjct: 1479 R-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA-KAQAEREAKELQQRMQE 1536
Query: 293 QWAGLVEKVQAAV 305
+ +V + +AAV
Sbjct: 1537 E---VVRREEAAV 1546
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 56.2 bits (134), Expect = 4e-08
Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 17 QAKVE-QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVT 75
QA+ E Q E E E R + E Q+ ++ ELA ++++++ ++ T
Sbjct: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELA--------------EQELEKQRQLAEGT 1682
Query: 76 QELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ R ++ + L+A ++E EQ + EE ARL +E AA Q
Sbjct: 1683 AQQRLAAEQELIRLRA-ETEQGEQQRQLLEEELARLQREAAAA---------------TQ 1726
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGA-REGAERG--L 192
R E++A L + E+ V LAS R + R + K+ +AG RE AE L
Sbjct: 1727 KRQELEAELAKVRAEMEVLLASKARAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARL 1784
Query: 193 SAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARME-EMGSRTRD----RL 247
A+ E + AA + A + L E+ A GE R + E E+ + ++ RL
Sbjct: 1785 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1844
Query: 248 DEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEP-------LVEDMQRQWAGLVEK 300
+ E A R +LEEQA Q + E A+L+ + LVED RQ + E+
Sbjct: 1845 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1904
Query: 301 VQA 303
+ A
Sbjct: 1905 ILA 1907
Score = 55.1 bits (131), Expect = 8e-08
Identities = 65/245 (26%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 56 RWVQTLSEQVQEELLSSQ-----VTQELRALMDETMKELKAYKSELEEQL--TPVAEETR 108
R + L +++QEE++ + Q+ R++ +E + ++ ++E++ + AE +R
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425
Query: 109 ARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTE-ELRVRLASHLRKLRKRLL 167
R+ +E++ + +L A G GE+QA+ ++ E E + R A + +R +
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGA----EGELQALRARAEEAEAQKRQAQEEAERLRRQV 1481
Query: 168 RDADDLQKRLAVYQAGAREGAE--------RGLSAIRE-RLGPLVEQGRVRAATVG---- 214
+D + +KR A + +R AE R L A+ E RL + R+R A V
Sbjct: 1482 QD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1540
Query: 215 -SLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
+A + Q A+A + RA E ++ L E VA++R + E +AQQ QAE
Sbjct: 1541 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAE 1597
Query: 274 AFQAR 278
A +AR
Sbjct: 1598 AERAR 1602
Score = 52.0 bits (123), Expect = 7e-07
Identities = 81/294 (27%), Positives = 128/294 (43%), Gaps = 33/294 (11%)
Query: 14 AGCQAKVEQA-VETEPEPELRQQTEWQSGQRWELALGRFWDYLRWV-QTLSE--QVQEEL 69
A QA E+ E E E R Q E + ++ + A + ++ QTL + QV++EL
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2166
Query: 70 ----LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEE---TRARLSKELQAAQARL 122
L + T + L+DE ++ LKA +E Q + V EE R ++ +EL +AR+
Sbjct: 2167 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-EELSKLKARI 2225
Query: 123 GADM-------EDVCGRLVQYRGEVQAMLGQSTEELRV--RLASHLRKLRKRLLRD---- 169
A+ +D R +Q E + + L V + A+ LR+L + L
Sbjct: 2226 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285
Query: 170 -ADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L++++ Q R AE L ++ L EQ R R Q L E Q +
Sbjct: 2286 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQAR-RLQEDKEQMAQQLAEETQGF 2342
Query: 229 GERL---RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL 279
L R R EM S +RL +++ +A+ EE AQ+ R QAE +L
Sbjct: 2343 QRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Score = 50.1 bits (118), Expect = 3e-06
Identities = 69/270 (25%), Positives = 119/270 (44%), Gaps = 30/270 (11%)
Query: 63 EQVQEELLSSQVTQELRALMDETMKEL-KAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
E Q L Q Q +A ++E + +L KA SELE Q V + R R ++++
Sbjct: 1851 EAFQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQR--RQVEEEILA 1907
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLL--------RDADD- 172
L A E + E+ + + + LR + + L R+R L R+A++
Sbjct: 1908 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967
Query: 173 LQKRLAVYQAGAR------EGAERGLSAIRE--RLGPLVEQGRVRAATVGSLAGQP---L 221
+QK LA + AR E ER + + E RL EQ R + A Q
Sbjct: 1968 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2027
Query: 222 QERAQAWG-ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
+E+A A+ ++ +++ + + LD+++ + AE + E+A++ R+QAE A+ +
Sbjct: 2028 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSR 2086
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAAVGTSAA 310
VE+ +R E+ QA AA
Sbjct: 2087 R----QVEEAERLKQSAEEQAQARAQAQAA 2112
Score = 48.9 bits (115), Expect = 6e-06
Identities = 62/243 (25%), Positives = 106/243 (43%), Gaps = 38/243 (15%)
Query: 54 YLRWV-QTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLS 112
Y++++ +TL +EE L+ Q E R + E L E + QL + +A+
Sbjct: 1311 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQAE 1365
Query: 113 KELQAAQARLGADM---EDVCGRLVQYRGEVQA---MLGQSTE---ELRVRLASHLRKLR 163
+E + Q R+ ++ E+ Q + +Q L QS+E + + R A + R
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425
Query: 164 KRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 223
R+ + ++ +L + R GAE L A+R R Q R
Sbjct: 1426 LRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKR---------------- 1468
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQV-AEVRAKLEEQA-----QQIRLQAEAFQA 277
+AQ ERLR ++++ R R E+ +V AE A E+Q +++RLQAE +
Sbjct: 1469 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1528
Query: 278 RLK 280
RL+
Sbjct: 1529 RLR 1531
Score = 48.9 bits (115), Expect = 6e-06
Identities = 58/270 (21%), Positives = 120/270 (44%), Gaps = 26/270 (9%)
Query: 14 AGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQ 73
A +A+ + A E +LR++ E ++ +R + LR Q ++++ ++
Sbjct: 2103 AQARAQAQAAAE-----KLRKEAEQEAARRAQAEQAA----LRQKQAADAEMEKHKKFAE 2153
Query: 74 VTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRL 133
T +A +++ + L+ E + Q + EE + ++ +AA+ R + E L
Sbjct: 2154 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE-----L 2208
Query: 134 VQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERG-- 191
R +++ + +L+ R+ + R L +LRD D+ Q+ L ++ AE
Sbjct: 2209 FSVRVQMEEL-----SKLKARIEAENRAL---ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2260
Query: 192 LSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVK 251
LS + L + A +LA + L+E+ QA E R + E + + + +
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQ 2318
Query: 252 EQVAEVRAKLEEQAQQIRLQAEAFQARLKS 281
EQ ++ E+ AQQ+ + + FQ L++
Sbjct: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Score = 48.1 bits (113), Expect = 1e-05
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 47/286 (16%)
Query: 21 EQAVETEPEPELR-QQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR 79
EQA + + + E R Q S E G D LR QV+EE+L+ + + E
Sbjct: 1860 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ----RRQVEEEILALKASFEKA 1915
Query: 80 ALMDETMKELKAYKSELEEQLTPV---AEET-RARLSKELQAAQARLGADMEDVCGRLVQ 135
A A K+ELE +L + AE+T R++ EL+AA+ R A E+ R +
Sbjct: 1916 A----------AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1965
Query: 136 YRGEVQAMLGQSTEELRVRLAS------------HLRKLRKRLLRDA--------DDLQK 175
R VQ L E R R A+ R+LR+R +++ + QK
Sbjct: 1966 ER--VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2023
Query: 176 RLAVYQ---AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
RL + A A + E+ L ++ +++Q R A A + + R QA E
Sbjct: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2083
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQAR 278
++R + +RL + E+ A+ RA+ + A+++R +AE AR
Sbjct: 2084 QSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2126
Score = 47.8 bits (112), Expect = 1e-05
Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 15/275 (5%)
Query: 7 ALLVTFLAGCQAKVEQAVE-----TEPEPELR--QQTEWQSGQRWELALGRFWDYLRWVQ 59
AL +F K E +E + E LR +Q E ++ ++ +LA + R +
Sbjct: 1907 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA----EEERRRR 1962
Query: 60 TLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQ 119
E+VQ+ L + + R E ++ LKA E +E+ +L +AAQ
Sbjct: 1963 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2022
Query: 120 ARLGADMEDVCGRLVQYRGEVQAMLGQSTEEL-RVRLASHLRKLRKRLLRDADDLQKRLA 178
RL A+ + + Q E+Q L Q L ++R + + +A +R A
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2082
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEE 238
E AER L E Q + A + A Q RAQA E+ R ++
Sbjct: 2083 AQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA--EQAALRQKQ 2139
Query: 239 MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
++ + EQ +A++E++ +RLQ E
Sbjct: 2140 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
Score = 37.4 bits (85), Expect = 0.018
Identities = 55/258 (21%), Positives = 114/258 (44%), Gaps = 9/258 (3%)
Query: 61 LSEQVQEELLSSQVTQELRALM--DETMKELKAYKSELEEQL--TPVAEETRARLSKELQ 116
L + E L +V + RA +E + + E+ E+L T +A + + L + L+
Sbjct: 2354 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2413
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ + D E + + + E + L Q + L+++ +++LL++ LQ+
Sbjct: 2414 IQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
+ + ER + + +L L + +A + Q Q++ + +RL A M
Sbjct: 2473 FLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASM 2530
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAG 296
EE R + + V+ + E++ +++ QQ L AE Q RL+ + L+E+ R
Sbjct: 2531 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RLREQLQ-LLEEQHRAALA 2588
Query: 297 LVEKVQAAVGTSAAPVPS 314
E+V A+ + +P+
Sbjct: 2589 HSEEVTASQVAATKTLPN 2606
Score = 35.4 bits (80), Expect = 0.067
Identities = 77/313 (24%), Positives = 125/313 (39%), Gaps = 38/313 (12%)
Query: 17 QAKVEQAVE-TEPEPE--------LRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQE 67
Q K QAV T PE E LR Q E Q + D LR Q + E++Q+
Sbjct: 1089 QLKEAQAVPATLPELEATKASLKKLRAQAEAQ-----QPTFDALRDELRGAQEVGERLQQ 1143
Query: 68 ELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR---LGA 124
V E+ + + L+ +++ L + T V + +L ++L+ + LGA
Sbjct: 1144 RHGERDV--EVERWRERVAQLLERWQAVLAQ--TDVRQRELEQLGRQLRYYRESADPLGA 1199
Query: 125 DMEDVCGRLVQYRGEVQAMLGQSTEELRVRLA------------SHLRKLRKRLLRDADD 172
++D R Q + A E+LR A ++ K+ + D
Sbjct: 1200 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1259
Query: 173 LQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
+ +L Y+A A + V Q V T S + + E L
Sbjct: 1260 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1319
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 292
R RMEE + E +E++AEV A LE+Q Q A+A +A+ + + L + MQ
Sbjct: 1320 R-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA-KAQAEREAKELQQRMQE 1377
Query: 293 QWAGLVEKVQAAV 305
+ +V + +AAV
Sbjct: 1378 E---VVRREEAAV 1387
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 56.2 bits (134), Expect = 4e-08
Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 17 QAKVE-QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVT 75
QA+ E Q E E E R + E Q+ ++ ELA ++++++ ++ T
Sbjct: 1645 QAEAEKQKEEAEREARRRGKAEEQAVRQRELA--------------EQELEKQRQLAEGT 1690
Query: 76 QELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ R ++ + L+A ++E EQ + EE ARL +E AA Q
Sbjct: 1691 AQQRLAAEQELIRLRA-ETEQGEQQRQLLEEELARLQREAAAA---------------TQ 1734
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGA-REGAERG--L 192
R E++A L + E+ V LAS R + R + K+ +AG RE AE L
Sbjct: 1735 KRQELEAELAKVRAEMEVLLASKARAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARL 1792
Query: 193 SAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARME-EMGSRTRD----RL 247
A+ E + AA + A + L E+ A GE R + E E+ + ++ RL
Sbjct: 1793 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1852
Query: 248 DEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEP-------LVEDMQRQWAGLVEK 300
+ E A R +LEEQA Q + E A+L+ + LVED RQ + E+
Sbjct: 1853 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1912
Query: 301 VQA 303
+ A
Sbjct: 1913 ILA 1915
Score = 55.1 bits (131), Expect = 8e-08
Identities = 65/245 (26%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 56 RWVQTLSEQVQEELLSSQ-----VTQELRALMDETMKELKAYKSELEEQL--TPVAEETR 108
R + L +++QEE++ + Q+ R++ +E + ++ ++E++ + AE +R
Sbjct: 1374 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1433
Query: 109 ARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTE-ELRVRLASHLRKLRKRLL 167
R+ +E++ + +L A G GE+QA+ ++ E E + R A + +R +
Sbjct: 1434 LRIEEEIRVVRLQLEATERQRGGA----EGELQALRARAEEAEAQKRQAQEEAERLRRQV 1489
Query: 168 RDADDLQKRLAVYQAGAREGAE--------RGLSAIRE-RLGPLVEQGRVRAATVG---- 214
+D + +KR A + +R AE R L A+ E RL + R+R A V
Sbjct: 1490 QD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1548
Query: 215 -SLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
+A + Q A+A + RA E ++ L E VA++R + E +AQQ QAE
Sbjct: 1549 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAE 1605
Query: 274 AFQAR 278
A +AR
Sbjct: 1606 AERAR 1610
Score = 52.0 bits (123), Expect = 7e-07
Identities = 81/294 (27%), Positives = 128/294 (43%), Gaps = 33/294 (11%)
Query: 14 AGCQAKVEQA-VETEPEPELRQQTEWQSGQRWELALGRFWDYLRWV-QTLSE--QVQEEL 69
A QA E+ E E E R Q E + ++ + A + ++ QTL + QV++EL
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2174
Query: 70 ----LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEE---TRARLSKELQAAQARL 122
L + T + L+DE ++ LKA +E Q + V EE R ++ +EL +AR+
Sbjct: 2175 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-EELSKLKARI 2233
Query: 123 GADM-------EDVCGRLVQYRGEVQAMLGQSTEELRV--RLASHLRKLRKRLLRD---- 169
A+ +D R +Q E + + L V + A+ LR+L + L
Sbjct: 2234 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2293
Query: 170 -ADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L++++ Q R AE L ++ L EQ R R Q L E Q +
Sbjct: 2294 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQAR-RLQEDKEQMAQQLAEETQGF 2350
Query: 229 GERL---RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL 279
L R R EM S +RL +++ +A+ EE AQ+ R QAE +L
Sbjct: 2351 QRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Score = 50.1 bits (118), Expect = 3e-06
Identities = 69/270 (25%), Positives = 119/270 (44%), Gaps = 30/270 (11%)
Query: 63 EQVQEELLSSQVTQELRALMDETMKEL-KAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
E Q L Q Q +A ++E + +L KA SELE Q V + R R ++++
Sbjct: 1859 EAFQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQR--RQVEEEILA 1915
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLL--------RDADD- 172
L A E + E+ + + + LR + + L R+R L R+A++
Sbjct: 1916 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1975
Query: 173 LQKRLAVYQAGAR------EGAERGLSAIRE--RLGPLVEQGRVRAATVGSLAGQP---L 221
+QK LA + AR E ER + + E RL EQ R + A Q
Sbjct: 1976 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2035
Query: 222 QERAQAWG-ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
+E+A A+ ++ +++ + + LD+++ + AE + E+A++ R+QAE A+ +
Sbjct: 2036 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSR 2094
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAAVGTSAA 310
VE+ +R E+ QA AA
Sbjct: 2095 R----QVEEAERLKQSAEEQAQARAQAQAA 2120
Score = 48.9 bits (115), Expect = 6e-06
Identities = 62/243 (25%), Positives = 106/243 (43%), Gaps = 38/243 (15%)
Query: 54 YLRWV-QTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLS 112
Y++++ +TL +EE L+ Q E R + E L E + QL + +A+
Sbjct: 1319 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQAE 1373
Query: 113 KELQAAQARLGADM---EDVCGRLVQYRGEVQA---MLGQSTE---ELRVRLASHLRKLR 163
+E + Q R+ ++ E+ Q + +Q L QS+E + + R A + R
Sbjct: 1374 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1433
Query: 164 KRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 223
R+ + ++ +L + R GAE L A+R R Q R
Sbjct: 1434 LRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKR---------------- 1476
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQV-AEVRAKLEEQA-----QQIRLQAEAFQA 277
+AQ ERLR ++++ R R E+ +V AE A E+Q +++RLQAE +
Sbjct: 1477 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1536
Query: 278 RLK 280
RL+
Sbjct: 1537 RLR 1539
Score = 48.9 bits (115), Expect = 6e-06
Identities = 58/270 (21%), Positives = 120/270 (44%), Gaps = 26/270 (9%)
Query: 14 AGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQ 73
A +A+ + A E +LR++ E ++ +R + LR Q ++++ ++
Sbjct: 2111 AQARAQAQAAAE-----KLRKEAEQEAARRAQAEQAA----LRQKQAADAEMEKHKKFAE 2161
Query: 74 VTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRL 133
T +A +++ + L+ E + Q + EE + ++ +AA+ R + E L
Sbjct: 2162 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE-----L 2216
Query: 134 VQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERG-- 191
R +++ + +L+ R+ + R L +LRD D+ Q+ L ++ AE
Sbjct: 2217 FSVRVQMEEL-----SKLKARIEAENRAL---ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2268
Query: 192 LSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVK 251
LS + L + A +LA + L+E+ QA E R + E + + + +
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQ 2326
Query: 252 EQVAEVRAKLEEQAQQIRLQAEAFQARLKS 281
EQ ++ E+ AQQ+ + + FQ L++
Sbjct: 2327 EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Score = 48.1 bits (113), Expect = 1e-05
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 47/286 (16%)
Query: 21 EQAVETEPEPELR-QQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR 79
EQA + + + E R Q S E G D LR QV+EE+L+ + + E
Sbjct: 1868 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ----RRQVEEEILALKASFEKA 1923
Query: 80 ALMDETMKELKAYKSELEEQLTPV---AEET-RARLSKELQAAQARLGADMEDVCGRLVQ 135
A A K+ELE +L + AE+T R++ EL+AA+ R A E+ R +
Sbjct: 1924 A----------AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 1973
Query: 136 YRGEVQAMLGQSTEELRVRLAS------------HLRKLRKRLLRDA--------DDLQK 175
R VQ L E R R A+ R+LR+R +++ + QK
Sbjct: 1974 ER--VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2031
Query: 176 RLAVYQ---AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
RL + A A + E+ L ++ +++Q R A A + + R QA E
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2091
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQAR 278
++R + +RL + E+ A+ RA+ + A+++R +AE AR
Sbjct: 2092 QSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2134
Score = 47.8 bits (112), Expect = 1e-05
Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 15/275 (5%)
Query: 7 ALLVTFLAGCQAKVEQAVE-----TEPEPELR--QQTEWQSGQRWELALGRFWDYLRWVQ 59
AL +F K E +E + E LR +Q E ++ ++ +LA + R +
Sbjct: 1915 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA----EEERRRR 1970
Query: 60 TLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQ 119
E+VQ+ L + + R E ++ LKA E +E+ +L +AAQ
Sbjct: 1971 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2030
Query: 120 ARLGADMEDVCGRLVQYRGEVQAMLGQSTEEL-RVRLASHLRKLRKRLLRDADDLQKRLA 178
RL A+ + + Q E+Q L Q L ++R + + +A +R A
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2090
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEE 238
E AER L E Q + A + A Q RAQA E+ R ++
Sbjct: 2091 AQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA--EQAALRQKQ 2147
Query: 239 MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
++ + EQ +A++E++ +RLQ E
Sbjct: 2148 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182
Score = 37.4 bits (85), Expect = 0.018
Identities = 55/258 (21%), Positives = 114/258 (44%), Gaps = 9/258 (3%)
Query: 61 LSEQVQEELLSSQVTQELRALM--DETMKELKAYKSELEEQL--TPVAEETRARLSKELQ 116
L + E L +V + RA +E + + E+ E+L T +A + + L + L+
Sbjct: 2362 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2421
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ + D E + + + E + L Q + L+++ +++LL++ LQ+
Sbjct: 2422 IQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2480
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
+ + ER + + +L L + +A + Q Q++ + +RL A M
Sbjct: 2481 FLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASM 2538
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAG 296
EE R + + V+ + E++ +++ QQ L AE Q RL+ + L+E+ R
Sbjct: 2539 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RLREQLQ-LLEEQHRAALA 2596
Query: 297 LVEKVQAAVGTSAAPVPS 314
E+V A+ + +P+
Sbjct: 2597 HSEEVTASQVAATKTLPN 2614
Score = 35.4 bits (80), Expect = 0.067
Identities = 77/313 (24%), Positives = 125/313 (39%), Gaps = 38/313 (12%)
Query: 17 QAKVEQAVE-TEPEPE--------LRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQE 67
Q K QAV T PE E LR Q E Q + D LR Q + E++Q+
Sbjct: 1097 QLKEAQAVPATLPELEATKASLKKLRAQAEAQ-----QPTFDALRDELRGAQEVGERLQQ 1151
Query: 68 ELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR---LGA 124
V E+ + + L+ +++ L + T V + +L ++L+ + LGA
Sbjct: 1152 RHGERDV--EVERWRERVAQLLERWQAVLAQ--TDVRQRELEQLGRQLRYYRESADPLGA 1207
Query: 125 DMEDVCGRLVQYRGEVQAMLGQSTEELRVRLA------------SHLRKLRKRLLRDADD 172
++D R Q + A E+LR A ++ K+ + D
Sbjct: 1208 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1267
Query: 173 LQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
+ +L Y+A A + V Q V T S + + E L
Sbjct: 1268 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1327
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 292
R RMEE + E +E++AEV A LE+Q Q A+A +A+ + + L + MQ
Sbjct: 1328 R-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA-KAQAEREAKELQQRMQE 1385
Query: 293 QWAGLVEKVQAAV 305
+ +V + +AAV
Sbjct: 1386 E---VVRREEAAV 1395
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 56.2 bits (134), Expect = 4e-08
Identities = 83/303 (27%), Positives = 132/303 (43%), Gaps = 48/303 (15%)
Query: 17 QAKVE-QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVT 75
QA+ E Q E E E R + E Q+ ++ ELA ++++++ ++ T
Sbjct: 1686 QAEAEKQKEEAEREARRRGKAEEQAVRQRELA--------------EQELEKQRQLAEGT 1731
Query: 76 QELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ R ++ + L+A ++E EQ + EE ARL +E AA Q
Sbjct: 1732 AQQRLAAEQELIRLRA-ETEQGEQQRQLLEEELARLQREAAAA---------------TQ 1775
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGA-REGAERG--L 192
R E++A L + E+ V LAS R + R + K+ +AG RE AE L
Sbjct: 1776 KRQELEAELAKVRAEMEVLLASKARAEEES--RSTSEKSKQRLEAEAGRFRELAEEAARL 1833
Query: 193 SAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARME-EMGSRTRD----RL 247
A+ E + AA + A + L E+ A GE R + E E+ + ++ RL
Sbjct: 1834 RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERL 1893
Query: 248 DEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEP-------LVEDMQRQWAGLVEK 300
+ E A R +LEEQA Q + E A+L+ + LVED RQ + E+
Sbjct: 1894 RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE 1953
Query: 301 VQA 303
+ A
Sbjct: 1954 ILA 1956
Score = 55.1 bits (131), Expect = 8e-08
Identities = 65/245 (26%), Positives = 118/245 (48%), Gaps = 30/245 (12%)
Query: 56 RWVQTLSEQVQEELLSSQ-----VTQELRALMDETMKELKAYKSELEEQL--TPVAEETR 108
R + L +++QEE++ + Q+ R++ +E + ++ ++E++ + AE +R
Sbjct: 1415 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1474
Query: 109 ARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTE-ELRVRLASHLRKLRKRLL 167
R+ +E++ + +L A G GE+QA+ ++ E E + R A + +R +
Sbjct: 1475 LRIEEEIRVVRLQLEATERQRGGA----EGELQALRARAEEAEAQKRQAQEEAERLRRQV 1530
Query: 168 RDADDLQKRLAVYQAGAREGAE--------RGLSAIRE-RLGPLVEQGRVRAATVG---- 214
+D + +KR A + +R AE R L A+ E RL + R+R A V
Sbjct: 1531 QD-ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ 1589
Query: 215 -SLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
+A + Q A+A + RA E ++ L E VA++R + E +AQQ QAE
Sbjct: 1590 VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ---QAE 1646
Query: 274 AFQAR 278
A +AR
Sbjct: 1647 AERAR 1651
Score = 52.0 bits (123), Expect = 7e-07
Identities = 81/294 (27%), Positives = 128/294 (43%), Gaps = 33/294 (11%)
Query: 14 AGCQAKVEQA-VETEPEPELRQQTEWQSGQRWELALGRFWDYLRWV-QTLSE--QVQEEL 69
A QA E+ E E E R Q E + ++ + A + ++ QTL + QV++EL
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2215
Query: 70 ----LSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEE---TRARLSKELQAAQARL 122
L + T + L+DE ++ LKA +E Q + V EE R ++ +EL +AR+
Sbjct: 2216 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-EELSKLKARI 2274
Query: 123 GADM-------EDVCGRLVQYRGEVQAMLGQSTEELRV--RLASHLRKLRKRLLRD---- 169
A+ +D R +Q E + + L V + A+ LR+L + L
Sbjct: 2275 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2334
Query: 170 -ADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L++++ Q R AE L ++ L EQ R R Q L E Q +
Sbjct: 2335 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQAR-RLQEDKEQMAQQLAEETQGF 2391
Query: 229 GERL---RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL 279
L R R EM S +RL +++ +A+ EE AQ+ R QAE +L
Sbjct: 2392 QRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444
Score = 50.1 bits (118), Expect = 3e-06
Identities = 69/270 (25%), Positives = 119/270 (44%), Gaps = 30/270 (11%)
Query: 63 EQVQEELLSSQVTQELRALMDETMKEL-KAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
E Q L Q Q +A ++E + +L KA SELE Q V + R R ++++
Sbjct: 1900 EAFQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQR--RQVEEEILA 1956
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLL--------RDADD- 172
L A E + E+ + + + LR + + L R+R L R+A++
Sbjct: 1957 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016
Query: 173 LQKRLAVYQAGAR------EGAERGLSAIRE--RLGPLVEQGRVRAATVGSLAGQP---L 221
+QK LA + AR E ER + + E RL EQ R + A Q
Sbjct: 2017 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2076
Query: 222 QERAQAWG-ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
+E+A A+ ++ +++ + + LD+++ + AE + E+A++ R+QAE A+ +
Sbjct: 2077 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSR 2135
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAAVGTSAA 310
VE+ +R E+ QA AA
Sbjct: 2136 R----QVEEAERLKQSAEEQAQARAQAQAA 2161
Score = 48.9 bits (115), Expect = 6e-06
Identities = 62/243 (25%), Positives = 106/243 (43%), Gaps = 38/243 (15%)
Query: 54 YLRWV-QTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLS 112
Y++++ +TL +EE L+ Q E R + E L E + QL + +A+
Sbjct: 1360 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQAE 1414
Query: 113 KELQAAQARLGADM---EDVCGRLVQYRGEVQA---MLGQSTE---ELRVRLASHLRKLR 163
+E + Q R+ ++ E+ Q + +Q L QS+E + + R A + R
Sbjct: 1415 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1474
Query: 164 KRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 223
R+ + ++ +L + R GAE L A+R R Q R
Sbjct: 1475 LRIEEEIRVVRLQLEATER-QRGGAEGELQALRARAEEAEAQKR---------------- 1517
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQV-AEVRAKLEEQA-----QQIRLQAEAFQA 277
+AQ ERLR ++++ R R E+ +V AE A E+Q +++RLQAE +
Sbjct: 1518 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAER 1577
Query: 278 RLK 280
RL+
Sbjct: 1578 RLR 1580
Score = 48.9 bits (115), Expect = 6e-06
Identities = 58/270 (21%), Positives = 120/270 (44%), Gaps = 26/270 (9%)
Query: 14 AGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQ 73
A +A+ + A E +LR++ E ++ +R + LR Q ++++ ++
Sbjct: 2152 AQARAQAQAAAE-----KLRKEAEQEAARRAQAEQAA----LRQKQAADAEMEKHKKFAE 2202
Query: 74 VTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRL 133
T +A +++ + L+ E + Q + EE + ++ +AA+ R + E L
Sbjct: 2203 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE-----L 2257
Query: 134 VQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERG-- 191
R +++ + +L+ R+ + R L +LRD D+ Q+ L ++ AE
Sbjct: 2258 FSVRVQMEEL-----SKLKARIEAENRAL---ILRDKDNTQRFLQEEAEKMKQVAEEAAR 2309
Query: 192 LSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVK 251
LS + L + A +LA + L+E+ QA E R + E + + + +
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQ 2367
Query: 252 EQVAEVRAKLEEQAQQIRLQAEAFQARLKS 281
EQ ++ E+ AQQ+ + + FQ L++
Sbjct: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Score = 48.1 bits (113), Expect = 1e-05
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 47/286 (16%)
Query: 21 EQAVETEPEPELR-QQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR 79
EQA + + + E R Q S E G D LR QV+EE+L+ + + E
Sbjct: 1909 EQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ----RRQVEEEILALKASFEKA 1964
Query: 80 ALMDETMKELKAYKSELEEQLTPV---AEET-RARLSKELQAAQARLGADMEDVCGRLVQ 135
A A K+ELE +L + AE+T R++ EL+AA+ R A E+ R +
Sbjct: 1965 A----------AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE 2014
Query: 136 YRGEVQAMLGQSTEELRVRLAS------------HLRKLRKRLLRDA--------DDLQK 175
R VQ L E R R A+ R+LR+R +++ + QK
Sbjct: 2015 ER--VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2072
Query: 176 RLAVYQ---AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
RL + A A + E+ L ++ +++Q R A A + + R QA E
Sbjct: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2132
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQAR 278
++R + +RL + E+ A+ RA+ + A+++R +AE AR
Sbjct: 2133 QSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR 2175
Score = 47.8 bits (112), Expect = 1e-05
Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 15/275 (5%)
Query: 7 ALLVTFLAGCQAKVEQAVE-----TEPEPELR--QQTEWQSGQRWELALGRFWDYLRWVQ 59
AL +F K E +E + E LR +Q E ++ ++ +LA + R +
Sbjct: 1956 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA----EEERRRR 2011
Query: 60 TLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQ 119
E+VQ+ L + + R E ++ LKA E +E+ +L +AAQ
Sbjct: 2012 EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2071
Query: 120 ARLGADMEDVCGRLVQYRGEVQAMLGQSTEEL-RVRLASHLRKLRKRLLRDADDLQKRLA 178
RL A+ + + Q E+Q L Q L ++R + + +A +R A
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2131
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEE 238
E AER L E Q + A + A Q RAQA E+ R ++
Sbjct: 2132 AQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA--EQAALRQKQ 2188
Query: 239 MGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAE 273
++ + EQ +A++E++ +RLQ E
Sbjct: 2189 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2223
Score = 37.4 bits (85), Expect = 0.018
Identities = 55/258 (21%), Positives = 114/258 (44%), Gaps = 9/258 (3%)
Query: 61 LSEQVQEELLSSQVTQELRALM--DETMKELKAYKSELEEQL--TPVAEETRARLSKELQ 116
L + E L +V + RA +E + + E+ E+L T +A + + L + L+
Sbjct: 2403 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE 2462
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ + D E + + + E + L Q + L+++ +++LL++ LQ+
Sbjct: 2463 IQRQQSDHDAERLREAIAELEREKEK-LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2521
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
+ + ER + + +L L + +A + Q Q++ + +RL A M
Sbjct: 2522 FLSEKDSLLQ-RERFIEQEKAKLEQLFQDEVAKAQQLRE-EQQRQQQQMEQERQRLVASM 2579
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAG 296
EE R + + V+ + E++ +++ QQ L AE Q RL+ + L+E+ R
Sbjct: 2580 EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RLREQLQ-LLEEQHRAALA 2637
Query: 297 LVEKVQAAVGTSAAPVPS 314
E+V A+ + +P+
Sbjct: 2638 HSEEVTASQVAATKTLPN 2655
Score = 35.4 bits (80), Expect = 0.067
Identities = 77/313 (24%), Positives = 125/313 (39%), Gaps = 38/313 (12%)
Query: 17 QAKVEQAVE-TEPEPE--------LRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQE 67
Q K QAV T PE E LR Q E Q + D LR Q + E++Q+
Sbjct: 1138 QLKEAQAVPATLPELEATKASLKKLRAQAEAQ-----QPTFDALRDELRGAQEVGERLQQ 1192
Query: 68 ELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR---LGA 124
V E+ + + L+ +++ L + T V + +L ++L+ + LGA
Sbjct: 1193 RHGERDV--EVERWRERVAQLLERWQAVLAQ--TDVRQRELEQLGRQLRYYRESADPLGA 1248
Query: 125 DMEDVCGRLVQYRGEVQAMLGQSTEELRVRLA------------SHLRKLRKRLLRDADD 172
++D R Q + A E+LR A ++ K+ + D
Sbjct: 1249 WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKD 1308
Query: 173 LQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERL 232
+ +L Y+A A + V Q V T S + + E L
Sbjct: 1309 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1368
Query: 233 RARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQR 292
R RMEE + E +E++AEV A LE+Q Q A+A +A+ + + L + MQ
Sbjct: 1369 R-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA-KAQAEREAKELQQRMQE 1426
Query: 293 QWAGLVEKVQAAV 305
+ +V + +AAV
Sbjct: 1427 E---VVRREEAAV 1436
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 54.7 bits (130), Expect = 1e-07
Identities = 63/248 (25%), Positives = 114/248 (45%), Gaps = 23/248 (9%)
Query: 60 TLSEQVQEELLSS--QVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQA 117
TL +++ EE S Q + L+ +DE +L+ K+E+EE+ + A + K+L+
Sbjct: 174 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQ--LKQLEE 231
Query: 118 AQARLG---ADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQ 174
ARL M D+ Q ++Q ++ + +EL V +R+ R+RL + +
Sbjct: 232 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEV-----VRQQRERLQEELSQAE 286
Query: 175 KRL--AVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSL-----AGQPLQERAQA 227
+ Q A GAE + + +R L E+ R TVG L LQE A+
Sbjct: 287 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 346
Query: 228 WGERLRARMEEMGSRTRD---RLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFE 284
LR +++ G+R R+ R++ +E VA+ + +++ +Q+ + L + E
Sbjct: 347 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKY-RQLTAHLQDVNRELTNQQE 405
Query: 285 PLVEDMQR 292
VE Q+
Sbjct: 406 ASVERQQQ 413
Score = 33.1 bits (74), Expect = 0.33
Identities = 44/186 (23%), Positives = 81/186 (43%), Gaps = 27/186 (14%)
Query: 86 MKELKAYKSELEEQLTPVAEETRA--RLSKELQAAQARLGADMEDVCGRLVQYRGEVQAM 143
+++++ +KS+++EQ + + + +KE A+ R +M D + E+ +
Sbjct: 121 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATL 175
Query: 144 LGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLV 203
+ EE L + L++R+ D+L L + +A E G +A +L L
Sbjct: 176 DKEMAEERAESLQQEVEALKERV----DELTTDLEILKAEIEEKGSDG-AASSYQLKQLE 230
Query: 204 EQGR------VRAATVGSLAGQP---LQERAQAWGERL------RARMEEMGSRTRDRLD 248
EQ VR + S Q LQ+ + + L R R++E S+ +D
Sbjct: 231 EQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
Query: 249 EVKEQV 254
E+KEQV
Sbjct: 291 ELKEQV 296
Score = 28.9 bits (63), Expect = 6.3
Identities = 27/119 (22%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 186 EGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQ-ERAQAWGERLRARMEEMGSRTR 244
EG + + E+L L + A + L +Q E+ Q W +++M+E + +
Sbjct: 84 EGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW----KSKMQEQQADLQ 139
Query: 245 DRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL--KSWFEPLVEDMQRQWAGLVEKV 301
RL E +++ E E +++ A+A + K E E +Q++ L E+V
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 198
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 54.7 bits (130), Expect = 1e-07
Identities = 63/248 (25%), Positives = 114/248 (45%), Gaps = 23/248 (9%)
Query: 60 TLSEQVQEELLSS--QVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQA 117
TL +++ EE S Q + L+ +DE +L+ K+E+EE+ + A + K+L+
Sbjct: 288 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQ--LKQLEE 345
Query: 118 AQARLG---ADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQ 174
ARL M D+ Q ++Q ++ + +EL V +R+ R+RL + +
Sbjct: 346 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEV-----VRQQRERLQEELSQAE 400
Query: 175 KRL--AVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSL-----AGQPLQERAQA 227
+ Q A GAE + + +R L E+ R TVG L LQE A+
Sbjct: 401 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 460
Query: 228 WGERLRARMEEMGSRTRD---RLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFE 284
LR +++ G+R R+ R++ +E VA+ + +++ +Q+ + L + E
Sbjct: 461 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKY-RQLTAHLQDVNRELTNQQE 519
Query: 285 PLVEDMQR 292
VE Q+
Sbjct: 520 ASVERQQQ 527
Score = 33.1 bits (74), Expect = 0.33
Identities = 44/186 (23%), Positives = 81/186 (43%), Gaps = 27/186 (14%)
Query: 86 MKELKAYKSELEEQLTPVAEETRA--RLSKELQAAQARLGADMEDVCGRLVQYRGEVQAM 143
+++++ +KS+++EQ + + + +KE A+ R +M D + E+ +
Sbjct: 235 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATL 289
Query: 144 LGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLV 203
+ EE L + L++R+ D+L L + +A E G +A +L L
Sbjct: 290 DKEMAEERAESLQQEVEALKERV----DELTTDLEILKAEIEEKGSDG-AASSYQLKQLE 344
Query: 204 EQGR------VRAATVGSLAGQP---LQERAQAWGERL------RARMEEMGSRTRDRLD 248
EQ VR + S Q LQ+ + + L R R++E S+ +D
Sbjct: 345 EQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 404
Query: 249 EVKEQV 254
E+KEQV
Sbjct: 405 ELKEQV 410
Score = 28.9 bits (63), Expect = 6.3
Identities = 27/119 (22%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 186 EGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQ-ERAQAWGERLRARMEEMGSRTR 244
EG + + E+L L + A + L +Q E+ Q W +++M+E + +
Sbjct: 198 EGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW----KSKMQEQQADLQ 253
Query: 245 DRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL--KSWFEPLVEDMQRQWAGLVEKV 301
RL E +++ E E +++ A+A + K E E +Q++ L E+V
Sbjct: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 312
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 54.7 bits (130), Expect = 1e-07
Identities = 63/248 (25%), Positives = 114/248 (45%), Gaps = 23/248 (9%)
Query: 60 TLSEQVQEELLSS--QVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQA 117
TL +++ EE S Q + L+ +DE +L+ K+E+EE+ + A + K+L+
Sbjct: 174 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQ--LKQLEE 231
Query: 118 AQARLG---ADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQ 174
ARL M D+ Q ++Q ++ + +EL V +R+ R+RL + +
Sbjct: 232 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEV-----VRQQRERLQEELSQAE 286
Query: 175 KRL--AVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSL-----AGQPLQERAQA 227
+ Q A GAE + + +R L E+ R TVG L LQE A+
Sbjct: 287 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 346
Query: 228 WGERLRARMEEMGSRTRD---RLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFE 284
LR +++ G+R R+ R++ +E VA+ + +++ +Q+ + L + E
Sbjct: 347 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKY-RQLTAHLQDVNRELTNQQE 405
Query: 285 PLVEDMQR 292
VE Q+
Sbjct: 406 ASVERQQQ 413
Score = 33.1 bits (74), Expect = 0.33
Identities = 44/186 (23%), Positives = 81/186 (43%), Gaps = 27/186 (14%)
Query: 86 MKELKAYKSELEEQLTPVAEETRA--RLSKELQAAQARLGADMEDVCGRLVQYRGEVQAM 143
+++++ +KS+++EQ + + + +KE A+ R +M D + E+ +
Sbjct: 121 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATL 175
Query: 144 LGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLV 203
+ EE L + L++R+ D+L L + +A E G +A +L L
Sbjct: 176 DKEMAEERAESLQQEVEALKERV----DELTTDLEILKAEIEEKGSDG-AASSYQLKQLE 230
Query: 204 EQGR------VRAATVGSLAGQP---LQERAQAWGERL------RARMEEMGSRTRDRLD 248
EQ VR + S Q LQ+ + + L R R++E S+ +D
Sbjct: 231 EQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 290
Query: 249 EVKEQV 254
E+KEQV
Sbjct: 291 ELKEQV 296
Score = 28.9 bits (63), Expect = 6.3
Identities = 27/119 (22%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 186 EGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQ-ERAQAWGERLRARMEEMGSRTR 244
EG + + E+L L + A + L +Q E+ Q W +++M+E + +
Sbjct: 84 EGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW----KSKMQEQQADLQ 139
Query: 245 DRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL--KSWFEPLVEDMQRQWAGLVEKV 301
RL E +++ E E +++ A+A + K E E +Q++ L E+V
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 198
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 54.7 bits (130), Expect = 1e-07
Identities = 63/248 (25%), Positives = 114/248 (45%), Gaps = 23/248 (9%)
Query: 60 TLSEQVQEELLSS--QVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQA 117
TL +++ EE S Q + L+ +DE +L+ K+E+EE+ + A + K+L+
Sbjct: 308 TLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQ--LKQLEE 365
Query: 118 AQARLG---ADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQ 174
ARL M D+ Q ++Q ++ + +EL V +R+ R+RL + +
Sbjct: 366 QNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEV-----VRQQRERLQEELSQAE 420
Query: 175 KRL--AVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSL-----AGQPLQERAQA 227
+ Q A GAE + + +R L E+ R TVG L LQE A+
Sbjct: 421 STIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARE 480
Query: 228 WGERLRARMEEMGSRTRD---RLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFE 284
LR +++ G+R R+ R++ +E VA+ + +++ +Q+ + L + E
Sbjct: 481 TELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKY-RQLTAHLQDVNRELTNQQE 539
Query: 285 PLVEDMQR 292
VE Q+
Sbjct: 540 ASVERQQQ 547
Score = 33.1 bits (74), Expect = 0.33
Identities = 44/186 (23%), Positives = 81/186 (43%), Gaps = 27/186 (14%)
Query: 86 MKELKAYKSELEEQLTPVAEETRA--RLSKELQAAQARLGADMEDVCGRLVQYRGEVQAM 143
+++++ +KS+++EQ + + + +KE A+ R +M D + E+ +
Sbjct: 255 LEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAI-----EMATL 309
Query: 144 LGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLV 203
+ EE L + L++R+ D+L L + +A E G +A +L L
Sbjct: 310 DKEMAEERAESLQQEVEALKERV----DELTTDLEILKAEIEEKGSDG-AASSYQLKQLE 364
Query: 204 EQGR------VRAATVGSLAGQP---LQERAQAWGERL------RARMEEMGSRTRDRLD 248
EQ VR + S Q LQ+ + + L R R++E S+ +D
Sbjct: 365 EQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTID 424
Query: 249 EVKEQV 254
E+KEQV
Sbjct: 425 ELKEQV 430
Score = 28.9 bits (63), Expect = 6.3
Identities = 27/119 (22%), Positives = 52/119 (43%), Gaps = 7/119 (5%)
Query: 186 EGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQ-ERAQAWGERLRARMEEMGSRTR 244
EG + + E+L L + A + L +Q E+ Q W +++M+E + +
Sbjct: 218 EGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEW----KSKMQEQQADLQ 273
Query: 245 DRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARL--KSWFEPLVEDMQRQWAGLVEKV 301
RL E +++ E E +++ A+A + K E E +Q++ L E+V
Sbjct: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERV 332
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 54.3 bits (129), Expect = 1e-07
Identities = 84/306 (27%), Positives = 139/306 (45%), Gaps = 42/306 (13%)
Query: 10 VTFLAGCQAKVEQAVET-----EPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQ 64
V+ L + ++EQ VE E E +LR TE ++ ++ E L + + +Q
Sbjct: 1066 VSALTKAKLRLEQQVEDLECSLEQEKKLRMDTE-RAKRKLEGDLKLTQESVADAAQDKQQ 1124
Query: 65 VQEEL---------LSSQVTQE--LRALMDETMKELKAYKSELEEQLTPVAEETRARLSK 113
++E+L LS +V E L A M + +KEL+A ELEE+L RAR+ K
Sbjct: 1125 LEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEEL-EAERAARARVEK 1183
Query: 114 ELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDL 173
+ +A ++E++ RL + G A GQ E R R A L +LR+ L A
Sbjct: 1184 Q----RAEAARELEELSERLEEAGG---ASAGQ-REGCRKREA-ELGRLRRELEEAALRH 1234
Query: 174 QKRLAVYQAGAREGAER------GLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQA 227
+ +A + EGA L +R++L E+ +R A RA+A
Sbjct: 1235 EATVAALRRKQAEGAAELGEQVDSLQRVRQKLEK--EKSELRMEVDDLAANVETLTRAKA 1292
Query: 228 WGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQ-ARLKSWFEPL 286
E+L E+ S + +++E++ Q+A+ Q+ RLQ E+ + +RL E L
Sbjct: 1293 SAEKLCRTYEDQLSEAKIKVEELQRQLADA------STQRGRLQTESGELSRLLEEKECL 1346
Query: 287 VEDMQR 292
+ + R
Sbjct: 1347 ISQLSR 1352
Score = 47.4 bits (111), Expect = 2e-05
Identities = 66/270 (24%), Positives = 113/270 (41%), Gaps = 30/270 (11%)
Query: 17 QAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRW--------VQTLSEQ---V 65
Q +E+A+E E Q E ++ QR LG LR ++TL + +
Sbjct: 1495 QRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNL 1554
Query: 66 QEEL--LSSQVTQELRAL--MDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
QEE+ L+ QV+ +++ +++T K L+ KSE++ L EE L E + R
Sbjct: 1555 QEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAAL----EEAEGALELE-ETKTLR 1609
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQ 181
+ ++ V + EV L + EE +H R + L+ + D + R
Sbjct: 1610 IQLELSQV-------KAEVDRKLAEKDEECANLRRNHQRAVES--LQASLDAETRARNEA 1660
Query: 182 AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGE-RLRARMEEMG 240
++ E L+ + +LG Q A + Q +E+A E RL A + E
Sbjct: 1661 LRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQA 1720
Query: 241 SRTRDRLDEVKEQVAEVRAKLEEQAQQIRL 270
R + ++ E+RA LE+ + RL
Sbjct: 1721 QALERRASLLAAELEELRAALEQGERSRRL 1750
Score = 40.4 bits (93), Expect = 0.002
Identities = 57/262 (21%), Positives = 113/262 (43%), Gaps = 26/262 (9%)
Query: 26 TEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQE-----ELLSSQVTQELRA 80
T E + T Q E GR + R L EQ Q LL++++ +ELRA
Sbjct: 1682 TRQATEAQAATRLMQAQLKEEQAGRDEEQ-RLAAELHEQAQALERRASLLAAEL-EELRA 1739
Query: 81 LMDETMKELKAYKSEL---EEQLTPVAEETRARLS--KELQAAQARLGADMEDVCGRLVQ 135
+++ + + + EL E+L + + L+ K+L+A A+L ++E+ +
Sbjct: 1740 ALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERRE 1799
Query: 136 YRGEVQAMLGQST---EELRVR--LASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAER 190
+ + + + EEL+ ++HL +++K L + +LQ RL + A G ++
Sbjct: 1800 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKK 1859
Query: 191 GLSAIRERLGPL-----VEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRD 245
+ + ++ L EQ + A G + + E R + +R +D
Sbjct: 1860 QVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNL----ARMQD 1915
Query: 246 RLDEVKEQVAEVRAKLEEQAQQ 267
+D+++ +V + + EE QQ
Sbjct: 1916 LVDKLQSKVKSYKRQFEEAEQQ 1937
Score = 34.3 bits (77), Expect = 0.15
Identities = 61/268 (22%), Positives = 109/268 (40%), Gaps = 36/268 (13%)
Query: 16 CQAKVEQAVETEPE-PELRQQTEWQSGQRWELAL--GRFWDYLRWVQTLSEQVQE-ELLS 71
C+ +Q E + + EL++Q S QR L G L + L Q+ + L+
Sbjct: 1298 CRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALA 1357
Query: 72 SQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCG 131
+Q +ELR ++E K K+ + + L + R + +E +A QA L +
Sbjct: 1358 AQSLEELRRQLEEESKA-KSALAHAVQALRHDCDLLREQHEEEAEA-QAELQRLLSKANA 1415
Query: 132 RLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERG 191
+ Q+R + +A Q TEEL ++ +K+LA+ A EG E
Sbjct: 1416 EVAQWRSKYEADAIQRTEEL-------------------EEAKKKLALRLQEAEEGVEAA 1456
Query: 192 LSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVK 251
+ +E+ ++R T L+ A A +++ L+E +
Sbjct: 1457 NAKCSS-----LEKAKLRLQTESEDVTLELERATSA-----AAALDKKQRHLERALEERR 1506
Query: 252 EQVAEVRAKLEEQAQQIR-LQAEAFQAR 278
Q E++ +LE ++ R L E F+ R
Sbjct: 1507 RQEEEMQRELEAAQRESRGLGTELFRLR 1534
>gi|226495417 coiled-coil domain containing 102A [Homo sapiens]
Length = 550
Score = 53.9 bits (128), Expect = 2e-07
Identities = 71/275 (25%), Positives = 126/275 (45%), Gaps = 24/275 (8%)
Query: 45 ELALGRFWDYLRWVQTLSEQVQEELLSS--QVTQELRALMDETMKELKAYKSELEEQLTP 102
+LAL R + L + + EEL + ++ ++L L + EL +LE++L
Sbjct: 273 KLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELG- 331
Query: 103 VAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKL 162
A + R EL+ RL A+ GR + E + L + ++LR ++ L
Sbjct: 332 -ARSSMDRKMAELRGEMERLQAENAAEWGRRERLETE-KLGLERENKKLRAQVGDLEEAL 389
Query: 163 RKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQ 222
+R + A L L QA E + L+ ++ G L +Q + + A + + Q
Sbjct: 390 ARRRRQTASALDCDLRASQAALFE-KNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQ 448
Query: 223 ERAQAWGERLRARMEEMG---SRTRDRLDEVKEQVAEVRAKLEEQAQQ---IRLQAEAFQ 276
A+ ++LR R+EE+ ++ D LDE Q +++ L+EQ +Q +++Q E Q
Sbjct: 449 HEAEV--KKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQ 506
Query: 277 ARLKSWFEPLVEDMQRQWAGLVEKVQAA-VGTSAA 310
+RL+ Q+Q A L K+++A GT A
Sbjct: 507 SRLR---------RQQQNAPLFGKIRSARFGTEEA 532
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 51.6 bits (122), Expect = 9e-07
Identities = 71/258 (27%), Positives = 122/258 (47%), Gaps = 39/258 (15%)
Query: 62 SEQVQEELLSSQV-TQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA 120
S ++QE+++ Q +ELRA + +EL+A + E++ RA+L K L+ AQA
Sbjct: 1089 SSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE-----GGARAQLLKSLREAQA 1143
Query: 121 RLGADMEDV-CGRLVQYRGEVQAM-LGQSTEELRVRLASHL------RKLRKRLLRDADD 172
L ED+ R+ + + E Q LG+ E LR L L ++LR + ++ +
Sbjct: 1144 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1203
Query: 173 LQKRL----AVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L+K L +++A +E +R A LG L EQ + A G A + + +A
Sbjct: 1204 LKKTLEEETRIHEAAVQELRQRHGQA----LGELAEQ--LEQARRGKGAWEKTRLALEAE 1257
Query: 229 GERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQA-EAFQARLKSWFEPLV 287
LRA + L +++ + R +LE Q Q+++ +A + +AR ++
Sbjct: 1258 VSELRAELSS--------LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA-----A 1304
Query: 288 EDMQRQWAGLVEKVQAAV 305
E +QR A L E V A+
Sbjct: 1305 EKLQRAQAEL-ENVSGAL 1321
Score = 48.9 bits (115), Expect = 6e-06
Identities = 63/264 (23%), Positives = 114/264 (43%), Gaps = 30/264 (11%)
Query: 22 QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRAL 81
+A E + EL+QQ+ + G+ GR L+EQ++ E +E R
Sbjct: 882 RAQELQKVQELQQQSAREVGE----LQGRVAQLEEERARLAEQLRAEAELCAEAEETRGR 937
Query: 82 MDETMKELKAYKSEL------EEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ +EL+ SEL EE+ + + + RL + +Q +A L A+ E +L
Sbjct: 938 LAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE-EGARQKLQL 996
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAI 195
+ +A + + E+L + L +L ++ L+ RLA + + A E E+ S
Sbjct: 997 EKVTTEAKMKKFEEDLLL-----LEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLN 1051
Query: 196 RERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVA 255
+ RL AT+ + + +E E+ R +E++ R E++EQ+
Sbjct: 1052 KLRL--------KYEATIADMEDRLRKE------EKGRQELEKLKRRLDGESSELQEQMV 1097
Query: 256 EVRAKLEEQAQQIRLQAEAFQARL 279
E + + EE Q+ + E QA L
Sbjct: 1098 EQQQRAEELRAQLGRKEEELQAAL 1121
Score = 45.4 bits (106), Expect = 6e-05
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 27/198 (13%)
Query: 83 DETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQA 142
++ +L+A +ELE++LT AE+ + RL +QA + + D++ GR
Sbjct: 1563 EQAANDLRAQVTELEDELT-AAEDAKLRLEVTVQALKTQHERDLQ---GR---------- 1608
Query: 143 MLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPL 202
++ EE R +LA LR RD + Q+ LAV AR+ E L ++ ++
Sbjct: 1609 --DEAGEERRRQLAKQLRDAEVE--RDEERKQRTLAV---AARKKLEGELEELKAQMA-- 1659
Query: 203 VEQGRVRAATVGSLAGQPLQERAQAWGE--RLRARMEEMGSRTRDRLDEVKEQVAEVRAK 260
G+ + V L Q + + W E R EE+ S+ R+ +K AEV
Sbjct: 1660 -SAGQGKEEAVKQLRKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1717
Query: 261 LEEQAQQIRLQAEAFQAR 278
EE A R + +A Q R
Sbjct: 1718 QEELAASDRARRQAQQDR 1735
Score = 42.0 bits (97), Expect = 7e-04
Identities = 63/264 (23%), Positives = 115/264 (43%), Gaps = 35/264 (13%)
Query: 58 VQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKEL-- 115
++ L ++++ L S+ QELR+ ++ + ELK E +E R R + L
Sbjct: 1173 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1232
Query: 116 ---QAAQARLGADMED-----VCGRLVQYRGEVQAM--LGQSTEELRVRLASHLRKLRKR 165
Q QAR G + + + + R E+ ++ Q E+ R RL L++++ R
Sbjct: 1233 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR 1292
Query: 166 LLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPL--VEQGRVRAATVGSLAGQPLQE 223
A D ++ +A A E +R + + G L E +R + S L +
Sbjct: 1293 ----AGDGERA----RAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1344
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQA---QQIRLQAEAFQARLK 280
+ E RA++ +GSR R ++ + A +R +LEE+A ++ + + QA+L
Sbjct: 1345 AQELLQEETRAKL-ALGSRVR----AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1399
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAA 304
W Q + AG +E + A
Sbjct: 1400 EW-----RRRQEEEAGALEAGEEA 1418
Score = 40.8 bits (94), Expect = 0.002
Identities = 50/205 (24%), Positives = 95/205 (46%), Gaps = 23/205 (11%)
Query: 64 QVQEELLSSQVTQELRALMDETMK---ELKAYKSEL--EEQLTPVAEETRARLSKELQAA 118
Q++EEL Q EL L D K ++++ +EL E + AE R +L +++Q
Sbjct: 1765 QLEEELEEEQSNSEL--LNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQEL 1822
Query: 119 QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLA 178
+ RLG + R +++ L Q+ E+L + R L +L+R A+ K +
Sbjct: 1823 RGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQE--TRERILSGKLVRRAEKRLKEVV 1880
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE--RAQAWGERLRARM 236
+ R A++ +R++L E+G +R + + +E RAQA RL+ +
Sbjct: 1881 LQVEEERRVADQ----LRDQL----EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL 1932
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKL 261
E++ + + + +V +R +L
Sbjct: 1933 EDV----TESAESMNREVTTLRNRL 1953
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 51.6 bits (122), Expect = 9e-07
Identities = 71/258 (27%), Positives = 122/258 (47%), Gaps = 39/258 (15%)
Query: 62 SEQVQEELLSSQV-TQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA 120
S ++QE+++ Q +ELRA + +EL+A + E++ RA+L K L+ AQA
Sbjct: 1081 SSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE-----GGARAQLLKSLREAQA 1135
Query: 121 RLGADMEDV-CGRLVQYRGEVQAM-LGQSTEELRVRLASHL------RKLRKRLLRDADD 172
L ED+ R+ + + E Q LG+ E LR L L ++LR + ++ +
Sbjct: 1136 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1195
Query: 173 LQKRL----AVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L+K L +++A +E +R A LG L EQ + A G A + + +A
Sbjct: 1196 LKKTLEEETRIHEAAVQELRQRHGQA----LGELAEQ--LEQARRGKGAWEKTRLALEAE 1249
Query: 229 GERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQA-EAFQARLKSWFEPLV 287
LRA + L +++ + R +LE Q Q+++ +A + +AR ++
Sbjct: 1250 VSELRAELSS--------LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA-----A 1296
Query: 288 EDMQRQWAGLVEKVQAAV 305
E +QR A L E V A+
Sbjct: 1297 EKLQRAQAEL-ENVSGAL 1313
Score = 48.9 bits (115), Expect = 6e-06
Identities = 63/264 (23%), Positives = 114/264 (43%), Gaps = 30/264 (11%)
Query: 22 QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRAL 81
+A E + EL+QQ+ + G+ GR L+EQ++ E +E R
Sbjct: 874 RAQELQKVQELQQQSAREVGE----LQGRVAQLEEERARLAEQLRAEAELCAEAEETRGR 929
Query: 82 MDETMKELKAYKSEL------EEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ +EL+ SEL EE+ + + + RL + +Q +A L A+ E +L
Sbjct: 930 LAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE-EGARQKLQL 988
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAI 195
+ +A + + E+L + L +L ++ L+ RLA + + A E E+ S
Sbjct: 989 EKVTTEAKMKKFEEDLLL-----LEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLN 1043
Query: 196 RERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVA 255
+ RL AT+ + + +E E+ R +E++ R E++EQ+
Sbjct: 1044 KLRL--------KYEATIADMEDRLRKE------EKGRQELEKLKRRLDGESSELQEQMV 1089
Query: 256 EVRAKLEEQAQQIRLQAEAFQARL 279
E + + EE Q+ + E QA L
Sbjct: 1090 EQQQRAEELRAQLGRKEEELQAAL 1113
Score = 45.4 bits (106), Expect = 6e-05
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 27/198 (13%)
Query: 83 DETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQA 142
++ +L+A +ELE++LT AE+ + RL +QA + + D++ GR
Sbjct: 1555 EQAANDLRAQVTELEDELT-AAEDAKLRLEVTVQALKTQHERDLQ---GR---------- 1600
Query: 143 MLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPL 202
++ EE R +LA LR RD + Q+ LAV AR+ E L ++ ++
Sbjct: 1601 --DEAGEERRRQLAKQLRDAEVE--RDEERKQRTLAV---AARKKLEGELEELKAQMA-- 1651
Query: 203 VEQGRVRAATVGSLAGQPLQERAQAWGE--RLRARMEEMGSRTRDRLDEVKEQVAEVRAK 260
G+ + V L Q + + W E R EE+ S+ R+ +K AEV
Sbjct: 1652 -SAGQGKEEAVKQLRKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1709
Query: 261 LEEQAQQIRLQAEAFQAR 278
EE A R + +A Q R
Sbjct: 1710 QEELAASDRARRQAQQDR 1727
Score = 42.0 bits (97), Expect = 7e-04
Identities = 63/264 (23%), Positives = 115/264 (43%), Gaps = 35/264 (13%)
Query: 58 VQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKEL-- 115
++ L ++++ L S+ QELR+ ++ + ELK E +E R R + L
Sbjct: 1165 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1224
Query: 116 ---QAAQARLGADMED-----VCGRLVQYRGEVQAM--LGQSTEELRVRLASHLRKLRKR 165
Q QAR G + + + + R E+ ++ Q E+ R RL L++++ R
Sbjct: 1225 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR 1284
Query: 166 LLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPL--VEQGRVRAATVGSLAGQPLQE 223
A D ++ +A A E +R + + G L E +R + S L +
Sbjct: 1285 ----AGDGERA----RAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1336
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQA---QQIRLQAEAFQARLK 280
+ E RA++ +GSR R ++ + A +R +LEE+A ++ + + QA+L
Sbjct: 1337 AQELLQEETRAKL-ALGSRVR----AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1391
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAA 304
W Q + AG +E + A
Sbjct: 1392 EW-----RRRQEEEAGALEAGEEA 1410
Score = 40.8 bits (94), Expect = 0.002
Identities = 50/205 (24%), Positives = 95/205 (46%), Gaps = 23/205 (11%)
Query: 64 QVQEELLSSQVTQELRALMDETMK---ELKAYKSEL--EEQLTPVAEETRARLSKELQAA 118
Q++EEL Q EL L D K ++++ +EL E + AE R +L +++Q
Sbjct: 1757 QLEEELEEEQSNSEL--LNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQEL 1814
Query: 119 QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLA 178
+ RLG + R +++ L Q+ E+L + R L +L+R A+ K +
Sbjct: 1815 RGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQE--TRERILSGKLVRRAEKRLKEVV 1872
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE--RAQAWGERLRARM 236
+ R A++ +R++L E+G +R + + +E RAQA RL+ +
Sbjct: 1873 LQVEEERRVADQ----LRDQL----EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL 1924
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKL 261
E++ + + + +V +R +L
Sbjct: 1925 EDV----TESAESMNREVTTLRNRL 1945
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 51.6 bits (122), Expect = 9e-07
Identities = 71/258 (27%), Positives = 122/258 (47%), Gaps = 39/258 (15%)
Query: 62 SEQVQEELLSSQV-TQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA 120
S ++QE+++ Q +ELRA + +EL+A + E++ RA+L K L+ AQA
Sbjct: 1122 SSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDE-----GGARAQLLKSLREAQA 1176
Query: 121 RLGADMEDV-CGRLVQYRGEVQAM-LGQSTEELRVRLASHL------RKLRKRLLRDADD 172
L ED+ R+ + + E Q LG+ E LR L L ++LR + ++ +
Sbjct: 1177 ALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTE 1236
Query: 173 LQKRL----AVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAW 228
L+K L +++A +E +R A LG L EQ + A G A + + +A
Sbjct: 1237 LKKTLEEETRIHEAAVQELRQRHGQA----LGELAEQ--LEQARRGKGAWEKTRLALEAE 1290
Query: 229 GERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQA-EAFQARLKSWFEPLV 287
LRA + L +++ + R +LE Q Q+++ +A + +AR ++
Sbjct: 1291 VSELRAELSS--------LQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEA-----A 1337
Query: 288 EDMQRQWAGLVEKVQAAV 305
E +QR A L E V A+
Sbjct: 1338 EKLQRAQAEL-ENVSGAL 1354
Score = 48.9 bits (115), Expect = 6e-06
Identities = 63/264 (23%), Positives = 114/264 (43%), Gaps = 30/264 (11%)
Query: 22 QAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRAL 81
+A E + EL+QQ+ + G+ GR L+EQ++ E +E R
Sbjct: 915 RAQELQKVQELQQQSAREVGE----LQGRVAQLEEERARLAEQLRAEAELCAEAEETRGR 970
Query: 82 MDETMKELKAYKSEL------EEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
+ +EL+ SEL EE+ + + + RL + +Q +A L A+ E +L
Sbjct: 971 LAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAE-EGARQKLQL 1029
Query: 136 YRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAI 195
+ +A + + E+L + L +L ++ L+ RLA + + A E E+ S
Sbjct: 1030 EKVTTEAKMKKFEEDLLL-----LEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLN 1084
Query: 196 RERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVA 255
+ RL AT+ + + +E E+ R +E++ R E++EQ+
Sbjct: 1085 KLRL--------KYEATIADMEDRLRKE------EKGRQELEKLKRRLDGESSELQEQMV 1130
Query: 256 EVRAKLEEQAQQIRLQAEAFQARL 279
E + + EE Q+ + E QA L
Sbjct: 1131 EQQQRAEELRAQLGRKEEELQAAL 1154
Score = 45.4 bits (106), Expect = 6e-05
Identities = 55/198 (27%), Positives = 89/198 (44%), Gaps = 27/198 (13%)
Query: 83 DETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQA 142
++ +L+A +ELE++LT AE+ + RL +QA + + D++ GR
Sbjct: 1596 EQAANDLRAQVTELEDELT-AAEDAKLRLEVTVQALKTQHERDLQ---GR---------- 1641
Query: 143 MLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPL 202
++ EE R +LA LR RD + Q+ LAV AR+ E L ++ ++
Sbjct: 1642 --DEAGEERRRQLAKQLRDAEVE--RDEERKQRTLAV---AARKKLEGELEELKAQMA-- 1692
Query: 203 VEQGRVRAATVGSLAGQPLQERAQAWGE--RLRARMEEMGSRTRDRLDEVKEQVAEVRAK 260
G+ + V L Q + + W E R EE+ S+ R+ +K AEV
Sbjct: 1693 -SAGQGKEEAVKQLRKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRL 1750
Query: 261 LEEQAQQIRLQAEAFQAR 278
EE A R + +A Q R
Sbjct: 1751 QEELAASDRARRQAQQDR 1768
Score = 42.0 bits (97), Expect = 7e-04
Identities = 63/264 (23%), Positives = 115/264 (43%), Gaps = 35/264 (13%)
Query: 58 VQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKEL-- 115
++ L ++++ L S+ QELR+ ++ + ELK E +E R R + L
Sbjct: 1206 LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGE 1265
Query: 116 ---QAAQARLGADMED-----VCGRLVQYRGEVQAM--LGQSTEELRVRLASHLRKLRKR 165
Q QAR G + + + + R E+ ++ Q E+ R RL L++++ R
Sbjct: 1266 LAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGR 1325
Query: 166 LLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPL--VEQGRVRAATVGSLAGQPLQE 223
A D ++ +A A E +R + + G L E +R + S L +
Sbjct: 1326 ----AGDGERA----RAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHD 1377
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQA---QQIRLQAEAFQARLK 280
+ E RA++ +GSR R ++ + A +R +LEE+A ++ + + QA+L
Sbjct: 1378 AQELLQEETRAKL-ALGSRVR----AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1432
Query: 281 SWFEPLVEDMQRQWAGLVEKVQAA 304
W Q + AG +E + A
Sbjct: 1433 EW-----RRRQEEEAGALEAGEEA 1451
Score = 40.8 bits (94), Expect = 0.002
Identities = 50/205 (24%), Positives = 95/205 (46%), Gaps = 23/205 (11%)
Query: 64 QVQEELLSSQVTQELRALMDETMK---ELKAYKSEL--EEQLTPVAEETRARLSKELQAA 118
Q++EEL Q EL L D K ++++ +EL E + AE R +L +++Q
Sbjct: 1798 QLEEELEEEQSNSEL--LNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQEL 1855
Query: 119 QARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLA 178
+ RLG + R +++ L Q+ E+L + R L +L+R A+ K +
Sbjct: 1856 RGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQE--TRERILSGKLVRRAEKRLKEVV 1913
Query: 179 VYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE--RAQAWGERLRARM 236
+ R A++ +R++L E+G +R + + +E RAQA RL+ +
Sbjct: 1914 LQVEEERRVADQ----LRDQL----EKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQREL 1965
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKL 261
E++ + + + +V +R +L
Sbjct: 1966 EDV----TESAESMNREVTTLRNRL 1986
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 51.6 bits (122), Expect = 9e-07
Identities = 56/230 (24%), Positives = 113/230 (49%), Gaps = 30/230 (13%)
Query: 69 LLSSQVTQELRALMDE-------TMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
LL S T++ A M E T+++ +A + ELEE++ + +E + L ++QA Q
Sbjct: 841 LLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQE-KNDLQLQVQAEQDN 899
Query: 122 LGADMEDVCGRLVQYRGEVQAMLG------QSTEELRVRLASHLRKLR---KRLLRDADD 172
L D E+ C +L++ + +++A + + EE+ L + RKL L +D DD
Sbjct: 900 LN-DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDD 958
Query: 173 LQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQ--PLQERAQAWGE 230
L+ LA + + E + + E + L E + L + LQE Q +
Sbjct: 959 LELTLAKVEK-EKHATENKVKNLTEEMAGLDE-------IIAKLTKEKKALQEAHQQALD 1010
Query: 231 RLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
L+ +++ S ++ ++ ++++QV ++ L EQ +++R+ E + +L+
Sbjct: 1011 DLQVEEDKVNSLSKSKV-KLEQQVDDLEGSL-EQEKKVRMDLERAKRKLE 1058
Score = 45.4 bits (106), Expect = 6e-05
Identities = 58/260 (22%), Positives = 124/260 (47%), Gaps = 22/260 (8%)
Query: 58 VQTLSEQVQ-EELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQ 116
V+ ++E+++ EE +++++T + R L DE ELK +LE L V +E A +K
Sbjct: 921 VKEMNERLEDEEEMNAELTAKKRKLEDE-CSELKKDIDDLELTLAKVEKEKHATENKVKN 979
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVR--LASHLRKLRKRLLRDADDLQ 174
+ G D ++ +L + + +Q Q+ ++L+V + L K + +L + DDL+
Sbjct: 980 LTEEMAGLD--EIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLE 1037
Query: 175 KRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRA 234
L + R ER A R+ G L ++ ++ L LQ E+L+
Sbjct: 1038 GSLE-QEKKVRMDLER---AKRKLEGDL----KLTQESIMDLENDKLQLE-----EKLKK 1084
Query: 235 RMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQAR--LKSWFEPLVEDMQR 292
+ ++ ++ ++++ + +++ KL+E +I E +A ++ E L D+ R
Sbjct: 1085 KEFDI-NQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSR 1143
Query: 293 QWAGLVEKVQAAVGTSAAPV 312
+ + E+++ A G ++ +
Sbjct: 1144 ELEEISERLEEAGGATSVQI 1163
Score = 42.0 bits (97), Expect = 7e-04
Identities = 46/224 (20%), Positives = 101/224 (45%), Gaps = 16/224 (7%)
Query: 66 QEELLSSQVTQELRALMDETMKELKAYKSELEE-----QLTPVAEETRARLSKELQAAQA 120
+ LL +++ +ELRA++++T + K + EL E QL + K++++
Sbjct: 1679 RNNLLQAEL-EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLT 1737
Query: 121 RLGADMEDV---CGRLVQYRGEVQAMLGQSTEELRVR--LASHLRKLRKRLLRDADDLQK 175
+L +++E+ C + + EEL+ ++HL +++K + + DLQ
Sbjct: 1738 QLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQH 1797
Query: 176 RLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRAR 235
RL + A +G ++ L + R+ L +G + A + +++ + L +
Sbjct: 1798 RLDEAEQIALKGGKKQLQKLEARVREL--EGELEAEQKRNAESVKGMRKSERRIKELTYQ 1855
Query: 236 MEEMGS---RTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQ 276
EE R +D +D+++ +V + + EE +Q F+
Sbjct: 1856 TEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1899
>gi|63079709 apolipoprotein AV [Homo sapiens]
Length = 366
Score = 51.2 bits (121), Expect = 1e-06
Identities = 56/250 (22%), Positives = 108/250 (43%), Gaps = 17/250 (6%)
Query: 51 FWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRAR 110
FWDY QT ++ + E + Q A + +++++ ++ E+L P++ R
Sbjct: 27 FWDYFS--QTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPR 84
Query: 111 LSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDA 170
L ++ + +L ++E+V RL Y E ++G + E LR +L + L +++
Sbjct: 85 LPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRV 144
Query: 171 DDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGE 230
+LQ++L V + G+ L L Q RV T +E + E
Sbjct: 145 QELQEQLRVVGEDTKAQLLGGVDEAWALLQGL--QSRVVHHT------GRFKELFHPYAE 196
Query: 231 RLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQ----QIRLQAEAFQARLKSWFEPL 286
L + +G ++ V A+L Q ++ L+A+A AR++ + L
Sbjct: 197 SL---VSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQL 253
Query: 287 VEDMQRQWAG 296
E++ R +AG
Sbjct: 254 REELSRAFAG 263
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/196 (22%), Positives = 85/196 (43%), Gaps = 23/196 (11%)
Query: 76 QELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQ 135
Q+L+ + M+++ EL+EQL V E+T+A+L + A A L + + R+V
Sbjct: 127 QQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALL----QGLQSRVVH 182
Query: 136 YRGEVQAM-----------LGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGA 184
+ G + + +G+ +EL +A H RL R L ++L +
Sbjct: 183 HTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKAL 242
Query: 185 REGAERGLSAIRERL-----GPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEM 239
++ L +RE L G E+G A + + +++R QA+ + ++
Sbjct: 243 HARIQQNLDQLREELSRAFAGTGTEEG---AGPDPQMLSEEVRQRLQAFRQDTYLQIAAF 299
Query: 240 GSRTRDRLDEVKEQVA 255
+EV++Q+A
Sbjct: 300 TRAIDQETEEVQQQLA 315
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 51.2 bits (121), Expect = 1e-06
Identities = 72/286 (25%), Positives = 121/286 (42%), Gaps = 53/286 (18%)
Query: 21 EQAVETEPEPELRQQTEWQSGQRWELALGRFWDYL-------RWVQTLSEQVQEELLSSQ 73
E A+E E +LR+ QS L WD L R Q+ + + EEL +
Sbjct: 679 ELAMEKEATEKLRKLLASQSS-----GLRGLWDCLPADLVGERSAQSKAAESLEELRACI 733
Query: 74 VT--------QELRALMDETMKELKAYKSELEEQLTPVA----------EETRARLSKEL 115
T Q++ A + E ++L+ S E T + E+ +L +EL
Sbjct: 734 STLVDRHREAQQVLARLQEENQQLRGSLSPCREPGTSLKAPASPQVAALEQDLGKLEEEL 793
Query: 116 QAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEE---LRVRLASHLR---KLRKRLLRD 169
+A QA + +++ G+++ +L Q+TEE LR R A+ LR K R L+
Sbjct: 794 RAVQATMSGKSQEI--------GKLKQLLYQATEEVAELRAREAASLRQHEKTRGSLVAQ 845
Query: 170 AD----DLQKRLAVYQAGAREGAE--RGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQE 223
A +L+ L Y RE ++ R R G L Q + + G+ E
Sbjct: 846 AQAWGQELKALLEKYNTACREVGRLREAVAEERRRSGDLAAQAAEQERQASEMRGR--SE 903
Query: 224 RAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIR 269
+ + E L+ +ME + RD+ ++KE + ++ +L E+ IR
Sbjct: 904 QFEKTAELLKEKMEHLIGACRDKEAKIKELLKKLE-QLSEEVLAIR 948
Score = 47.8 bits (112), Expect = 1e-05
Identities = 75/306 (24%), Positives = 136/306 (44%), Gaps = 50/306 (16%)
Query: 25 ETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDE 84
E P+PE + Q Q+ ++G + L + +E++++ LL+SQ + LR L D
Sbjct: 655 EFVPKPEAQVQL-----QQLRQSVGLLTNELAMEKEATEKLRK-LLASQ-SSGLRGLWDC 707
Query: 85 TMKELKAYKSELEEQLTPVAEETRARLS------KELQAAQARLGADMEDVCGRLVQYRG 138
+L +S + + EE RA +S +E Q ARL + + + G L R
Sbjct: 708 LPADLVGERSA-QSKAAESLEELRACISTLVDRHREAQQVLARLQEENQQLRGSLSPCRE 766
Query: 139 EVQAMLGQSTEELRV------RLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGL 192
++ ++ ++ +L LR ++ + + ++ K + E AE
Sbjct: 767 PGTSLKAPASPQVAALEQDLGKLEEELRAVQATMSGKSQEIGKLKQLLYQATEEVAE--- 823
Query: 193 SAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKE 252
+R R + Q T GSL Q AQAWG+ L+A +E+ + R+ + ++E
Sbjct: 824 --LRAREAASLRQ---HEKTRGSLVAQ-----AQAWGQELKALLEKYNTACRE-VGRLRE 872
Query: 253 QVAEVR----------AKLEEQAQQIRLQAEAFQAR---LKSWFEPLV---EDMQRQWAG 296
VAE R A+ E QA ++R ++E F+ LK E L+ D + +
Sbjct: 873 AVAEERRRSGDLAAQAAEQERQASEMRGRSEQFEKTAELLKEKMEHLIGACRDKEAKIKE 932
Query: 297 LVEKVQ 302
L++K++
Sbjct: 933 LLKKLE 938
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 50.1 bits (118), Expect = 3e-06
Identities = 63/270 (23%), Positives = 118/270 (43%), Gaps = 39/270 (14%)
Query: 58 VQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQA 117
+Q L EQ++EE + Q Q + + +K+L+ EEQ+ + E+ +L+KE +
Sbjct: 945 IQELEEQLEEEESARQKLQLEKVTTEAKLKKLE------EEQI--ILEDQNCKLAKEKKL 996
Query: 118 AQARLG------ADMEDVCGRLVQYRGEVQAMLGQSTEELR--VRLASHLRKLRKRLLRD 169
+ R+ + E+ L + + + +AM+ E LR + L K R++L D
Sbjct: 997 LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 1056
Query: 170 ADDLQKRLAVYQAGARE------GAERGLSAIRERLGPLVEQGRVRAATVGSLAGQ--PL 221
+ DL ++A QA E E L A R+ Q + + L Q L
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 222 QE----------RAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQ 271
QE +A+ L +E + + D LD Q E+R+K E Q++ +
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ-QELRSKRE---QEVNIL 1172
Query: 272 AEAFQARLKSWFEPLVEDMQRQWAGLVEKV 301
+ + K+ E +++M+++ + VE++
Sbjct: 1173 KKTLEEEAKT-HEAQIQEMRQKHSQAVEEL 1201
Score = 43.9 bits (102), Expect = 2e-04
Identities = 63/267 (23%), Positives = 115/267 (43%), Gaps = 41/267 (15%)
Query: 58 VQTLSEQVQEELL----SSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSK 113
++TL Q+ E L Q EL A +E L A K ELEE + + AR+ +
Sbjct: 871 METLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEE----ICHDLEARVEE 926
Query: 114 E------LQAAQARLGADMEDVCGRLVQYRGEVQAM-LGQSTEELRVRLASH----LRKL 162
E LQA + ++ +++++ +L + Q + L + T E +++ L
Sbjct: 927 EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ 986
Query: 163 RKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQ 222
+L ++ L+ R+A + E E+ S L + A + L + +
Sbjct: 987 NCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS--------LAKLKNKHEAMITDLEERLRR 1038
Query: 223 ERAQAWG-ERLRARMEEMGSRTRDRLDEVKEQVAEVRAKL-----EEQAQQIRLQAEAFQ 276
E Q E+ R ++E + D++ E++ Q+AE++ +L E QA R++ EA Q
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQ 1098
Query: 277 --------ARLKSWFEPLVEDMQRQWA 295
L+S L ED++ + A
Sbjct: 1099 KNMALKKIRELESQISELQEDLESERA 1125
Score = 30.8 bits (68), Expect = 1.7
Identities = 24/84 (28%), Positives = 44/84 (52%), Gaps = 4/84 (4%)
Query: 221 LQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQ---AQQIRLQAEAFQA 277
LQE+ QA E L A EE+ +R + E++E ++ A++EE+ Q ++ + + Q
Sbjct: 885 LQEQLQAETE-LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQ 943
Query: 278 RLKSWFEPLVEDMQRQWAGLVEKV 301
++ E L E+ + +EKV
Sbjct: 944 NIQELEEQLEEEESARQKLQLEKV 967
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 50.1 bits (118), Expect = 3e-06
Identities = 56/238 (23%), Positives = 104/238 (43%), Gaps = 27/238 (11%)
Query: 59 QTLSEQVQEELLS--SQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQ 116
Q+L E+ ++++L +V + R + +ELK +S LEE++T + E SK L+
Sbjct: 309 QSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAH----SKTLE 364
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ +E V ++ + ++L++ L K + L D + LQ+
Sbjct: 365 ELAWKHHMAIEAVHSNAIRDK-----------KKLQMDLEEQHNKDKLNLEEDKNQLQQE 413
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
L +E E L+ + +G L + R +GS G L Q ERL+ +
Sbjct: 414 LE----NLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG--LIASLQDSQERLQNEL 467
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQW 294
+ T+D L E K+ + V +LE++ QQ A + K + + D++ +W
Sbjct: 468 D----LTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKW 521
Score = 42.0 bits (97), Expect = 7e-04
Identities = 57/225 (25%), Positives = 104/225 (46%), Gaps = 34/225 (15%)
Query: 84 ETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAM 143
+T+K + + +E + ++E A L KE Q +A L + + L + E ++
Sbjct: 144 DTLKRSQLFTAESLQ----ASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSL 199
Query: 144 LGQSTEELRVRLA---SHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLG 200
L + ++L+ LA ++++ L+K+L DD ++ + +E E L+A RERL
Sbjct: 200 LDKC-QKLQTALAIAENNVQVLQKQL----DDAKEGEMALLSKHKE-VESELAAARERLQ 253
Query: 201 PLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAK 260
++A+ +G L + Q E +E SR +RL +++E+ A +R+K
Sbjct: 254 QQASDLVLKASHIGML------QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSK 307
Query: 261 L----EEQAQQI-----------RLQAEAFQARLKSWFEPLVEDM 290
EEQ QQI R Q E ++ LK+ L E++
Sbjct: 308 TQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEV 352
Score = 36.6 bits (83), Expect = 0.030
Identities = 57/255 (22%), Positives = 106/255 (41%), Gaps = 32/255 (12%)
Query: 45 ELALGRFWDYLRWVQTLSEQVQEEL-LSSQVTQELRALMDETMKELKAYKSELEEQLTPV 103
E LG + +Q E++Q EL L+ +E + + EL+ + + EE + +
Sbjct: 443 EQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 502
Query: 104 AEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLR 163
EE + ++ K + + ++ C +L + L EE + S L +L+
Sbjct: 503 KEEEKLKVDKMAHDLEIKWTENLRQECSKL-------REELRLQHEEDKKSAMSQLLQLK 555
Query: 164 KRLLRDA-DDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQ 222
R A D QK++ E +S +++ L + Q + ++ L Q Q
Sbjct: 556 DREKNAARDSWQKKV--------EDLLNQISLLKQNLEIQLSQSQT---SLQQLQAQFTQ 604
Query: 223 ERAQAWGERLRARMEEMGSRTRDRLDEVKE------QVAEVRAKLEEQAQQIRLQAEAFQ 276
ER +RL +EE+ + + R +KE Q E + E++A + LQ +
Sbjct: 605 ER-----QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQ-QKHS 658
Query: 277 ARLKSWFEPLVEDMQ 291
A L+S + E M+
Sbjct: 659 AELQSLKDAHRESME 673
Score = 31.6 bits (70), Expect = 0.97
Identities = 46/244 (18%), Positives = 100/244 (40%), Gaps = 38/244 (15%)
Query: 62 SEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
++ VQ + S+ +E+R +E ++ + + E+ E+ +A +E+Q
Sbjct: 25 AQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQ----E 80
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDAD---------- 171
L +D + + + + + + E L ++ LR RK+L+ D +
Sbjct: 81 LLKSQQDHSASVNKGQEKAEELHRMEVESLN-KMLEELRLERKKLIEDYEGKLNKAQSFY 139
Query: 172 ----DLQKRLAVYQAGAREGAE----------RGLSAI-RERLGPLVEQGRVRAATVGSL 216
D KR ++ A + + ++ +G AI R+ +G L + ++ GSL
Sbjct: 140 ERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSL 199
Query: 217 AG--QPLQERAQAWGERLRARMEEMGSRTRDRL------DEVKEQVAEVRAKLEEQAQQI 268
Q LQ ++ +++ + EV+ ++A R +L++QA +
Sbjct: 200 LDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDL 259
Query: 269 RLQA 272
L+A
Sbjct: 260 VLKA 263
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 50.1 bits (118), Expect = 3e-06
Identities = 56/238 (23%), Positives = 104/238 (43%), Gaps = 27/238 (11%)
Query: 59 QTLSEQVQEELLS--SQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQ 116
Q+L E+ ++++L +V + R + +ELK +S LEE++T + E SK L+
Sbjct: 429 QSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAH----SKTLE 484
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKR 176
+ +E V ++ + ++L++ L K + L D + LQ+
Sbjct: 485 ELAWKHHMAIEAVHSNAIRDK-----------KKLQMDLEEQHNKDKLNLEEDKNQLQQE 533
Query: 177 LAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARM 236
L +E E L+ + +G L + R +GS G L Q ERL+ +
Sbjct: 534 LE----NLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEG--LIASLQDSQERLQNEL 587
Query: 237 EEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQW 294
+ T+D L E K+ + V +LE++ QQ A + K + + D++ +W
Sbjct: 588 D----LTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKW 641
Score = 42.0 bits (97), Expect = 7e-04
Identities = 57/225 (25%), Positives = 104/225 (46%), Gaps = 34/225 (15%)
Query: 84 ETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAM 143
+T+K + + +E + ++E A L KE Q +A L + + L + E ++
Sbjct: 264 DTLKRSQLFTAESLQ----ASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSL 319
Query: 144 LGQSTEELRVRLA---SHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLG 200
L + ++L+ LA ++++ L+K+L DD ++ + +E E L+A RERL
Sbjct: 320 LDKC-QKLQTALAIAENNVQVLQKQL----DDAKEGEMALLSKHKE-VESELAAARERLQ 373
Query: 201 PLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAK 260
++A+ +G L + Q E +E SR +RL +++E+ A +R+K
Sbjct: 374 QQASDLVLKASHIGML------QATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSK 427
Query: 261 L----EEQAQQI-----------RLQAEAFQARLKSWFEPLVEDM 290
EEQ QQI R Q E ++ LK+ L E++
Sbjct: 428 TQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEV 472
Score = 36.6 bits (83), Expect = 0.030
Identities = 57/255 (22%), Positives = 106/255 (41%), Gaps = 32/255 (12%)
Query: 45 ELALGRFWDYLRWVQTLSEQVQEEL-LSSQVTQELRALMDETMKELKAYKSELEEQLTPV 103
E LG + +Q E++Q EL L+ +E + + EL+ + + EE + +
Sbjct: 563 EQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAM 622
Query: 104 AEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLR 163
EE + ++ K + + ++ C +L + L EE + S L +L+
Sbjct: 623 KEEEKLKVDKMAHDLEIKWTENLRQECSKL-------REELRLQHEEDKKSAMSQLLQLK 675
Query: 164 KRLLRDA-DDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQ 222
R A D QK++ E +S +++ L + Q + ++ L Q Q
Sbjct: 676 DREKNAARDSWQKKV--------EDLLNQISLLKQNLEIQLSQSQT---SLQQLQAQFTQ 724
Query: 223 ERAQAWGERLRARMEEMGSRTRDRLDEVKE------QVAEVRAKLEEQAQQIRLQAEAFQ 276
ER +RL +EE+ + + R +KE Q E + E++A + LQ +
Sbjct: 725 ER-----QRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQ-QKHS 778
Query: 277 ARLKSWFEPLVEDMQ 291
A L+S + E M+
Sbjct: 779 AELQSLKDAHRESME 793
Score = 32.7 bits (73), Expect = 0.43
Identities = 60/263 (22%), Positives = 110/263 (41%), Gaps = 43/263 (16%)
Query: 76 QELRALMDETMKELKAYKSELEEQL-----TPVAEETRARLSKELQAAQARLGA------ 124
+E++ ++ ET +++ YKS++ E+L V E + K Q A A
Sbjct: 78 EEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVE 137
Query: 125 DMEDVCG------RLVQYRGEVQAMLGQSTEELR------------VRLASHLRKLRKRL 166
DM+ +C R+V EV+ + + E+LR RLA L L+
Sbjct: 138 DMQ-LCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLA--LEDLQAAH 194
Query: 167 LRDADDLQKRLAVYQAGAREGAERGLSAIR---ERLGPLVEQGRV-RAATVGSLAGQPLQ 222
R+ +L K + A +G E+ R E L ++E+ R+ R + G+
Sbjct: 195 RREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGK--L 252
Query: 223 ERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSW 282
+AQ++ ER ++ T + L KE+ A++R + + Q +R + L+
Sbjct: 253 NKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQ-- 310
Query: 283 FEPLVEDMQRQWAGLVEKVQAAV 305
+V+D +K+Q A+
Sbjct: 311 ---MVQDEAGSLLDKCQKLQTAL 330
Score = 31.6 bits (70), Expect = 0.97
Identities = 46/244 (18%), Positives = 100/244 (40%), Gaps = 38/244 (15%)
Query: 62 SEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQAR 121
++ VQ + S+ +E+R +E ++ + + E+ E+ +A +E+Q
Sbjct: 145 AQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQ----E 200
Query: 122 LGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDAD---------- 171
L +D + + + + + + E L ++ LR RK+L+ D +
Sbjct: 201 LLKSQQDHSASVNKGQEKAEELHRMEVESLN-KMLEELRLERKKLIEDYEGKLNKAQSFY 259
Query: 172 ----DLQKRLAVYQAGAREGAE----------RGLSAI-RERLGPLVEQGRVRAATVGSL 216
D KR ++ A + + ++ +G AI R+ +G L + ++ GSL
Sbjct: 260 ERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSL 319
Query: 217 AG--QPLQERAQAWGERLRARMEEMGSRTRDRL------DEVKEQVAEVRAKLEEQAQQI 268
Q LQ ++ +++ + EV+ ++A R +L++QA +
Sbjct: 320 LDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARERLQQQASDL 379
Query: 269 RLQA 272
L+A
Sbjct: 380 VLKA 383
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 49.7 bits (117), Expect = 3e-06
Identities = 52/220 (23%), Positives = 102/220 (46%), Gaps = 22/220 (10%)
Query: 66 QEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGAD 125
QEEL + +EL+A + +EL+A + +LEE + AEE + RL +++ QAR +
Sbjct: 334 QEEL--ERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVE-LQARFSTE 390
Query: 126 MEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAR 185
+E + ++ Q EE + +S L + +R +R+ +D+ +L R
Sbjct: 391 LER------------EKLIRQQMEEQVAQKSSELEQYLQR-VRELEDMYLKLQEALEDER 437
Query: 186 EGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRD 245
+ A + +R+ L+E+ + A + + Q++A E + +E
Sbjct: 438 Q-ARQDEETVRKLQARLLEEESSKRAELEKWHLE--QQQAIQTTEAEKQELENQRVLKEQ 494
Query: 246 RLDEVKEQVAEV---RAKLEEQAQQIRLQAEAFQARLKSW 282
L E EQ+ ++ R + EQ ++++ + E + KSW
Sbjct: 495 ALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSW 534
Score = 30.4 bits (67), Expect = 2.2
Identities = 50/244 (20%), Positives = 96/244 (39%), Gaps = 29/244 (11%)
Query: 19 KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQEL 78
K + A + E E ++++ ++ EL R + + S +EE Q EL
Sbjct: 328 KKQLAEQEELERQMKELQAANESKQQELEAVR----KKLEEAASRAAEEEKKRLQTQVEL 383
Query: 79 RALMDETMKELKAYKSELEEQLTPVAEETRARLS--KELQAAQARLGADMEDVCGRLVQY 136
+A ++ K + ++EEQ+ + E L +EL+ +L +ED
Sbjct: 384 QARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALED-------- 435
Query: 137 RGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIR 196
E QA + T +RKL+ RLL + + L + ++ + + +
Sbjct: 436 --ERQARQDEET----------VRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQ 483
Query: 197 ERLGPLVEQGRVRAATVGSLAGQPLQERAQAWG--ERLRARMEEMGSRTRDRLDEVKEQV 254
E V + + + L L ER QA E ++ ++E ++T+ D+V
Sbjct: 484 ELENQRVLKEQALQEAMEQLEQLEL-ERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHE 542
Query: 255 AEVR 258
+R
Sbjct: 543 GLIR 546
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 49.3 bits (116), Expect = 4e-06
Identities = 60/254 (23%), Positives = 116/254 (45%), Gaps = 33/254 (12%)
Query: 61 LSEQV-----QEELLSSQVTQELRALMDETMKELKAYKSEL---EEQLTPVAEETRARLS 112
L EQV + LL S++ ++LR+L ++T + + + EL E++ + + LS
Sbjct: 1679 LKEQVAVAERRNSLLQSEL-EDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLS 1737
Query: 113 --KELQAAQARLGADMEDV---CGRLVQYRGEVQAMLGQSTEELRVR--LASHLRKLRKR 165
K+L+A AR+ + E+V C + + +EEL+ + +HL + R+
Sbjct: 1738 QKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTREN 1797
Query: 166 LLRDADDLQKRLAVYQ----AGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPL 221
+ + DLQKRLA + G+R+ ++ S +RE G L +G +R + + L
Sbjct: 1798 MEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGEL--EGEIRRSAEAQRGARRL 1855
Query: 222 QERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRL---QAEAFQAR 278
ER + + L ++ Q+ +++ K++ QQ+ + QA + ++
Sbjct: 1856 --------ERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSK 1907
Query: 279 LKSWFEPLVEDMQR 292
K L E +R
Sbjct: 1908 YKKQQHELNEVKER 1921
Score = 39.7 bits (91), Expect = 0.004
Identities = 67/278 (24%), Positives = 118/278 (42%), Gaps = 49/278 (17%)
Query: 19 KVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSS------ 72
++++A E R + ++ + +L LG L V++ + ++ ++ L S
Sbjct: 1408 RLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALAD 1467
Query: 73 --QVTQELRALMDETMKELKAYKSEL-------EEQLTPVAEETRARLSKELQ------A 117
Q +E +AL+D + KE++A +EL EE + V +ET R +K LQ
Sbjct: 1468 WKQKHEESQALLDASQKEVQALSTELLKLKNTYEESI--VGQETLRRENKNLQEEISNLT 1525
Query: 118 AQARLG----ADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDL 173
Q R G +ME V + + + EVQ L + TE R S + + LL +L
Sbjct: 1526 NQVREGTKNLTEMEKVKKLIEEEKTEVQVTL-EETEGALERNESKILHFQLELLEAKAEL 1584
Query: 174 QKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGE--R 231
+++L+ E+ + R + T+ SL L A++ E R
Sbjct: 1585 ERKLS------------------EKDEEIENFRRKQQCTIDSLQSS-LDSEAKSRIEVTR 1625
Query: 232 LRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIR 269
L+ +MEE + +L QV+E L + QI+
Sbjct: 1626 LKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIK 1663
Score = 36.6 bits (83), Expect = 0.030
Identities = 63/309 (20%), Positives = 122/309 (39%), Gaps = 66/309 (21%)
Query: 58 VQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARL--SKEL 115
+QT + ++E+L + + T RA M+ +L ++L E+L V + A+L +K+
Sbjct: 1123 LQTQIKDLKEKLEAERTT---RAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQ 1179
Query: 116 QAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQK 175
+ +L DME+ ++ S EL ++ +L++++++L +D DLQ
Sbjct: 1180 ETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQV-ENLQQVKQKLEKDKSDLQL 1238
Query: 176 RL------AVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWG 229
+ A+ AE+ + ERL + + V LA ++ + W
Sbjct: 1239 EVDDLLTRVEQMTRAKANAEKLCTLYEERL----HEATAKLDKVTQLANDLAAQKTKLWS 1294
Query: 230 ER------------------------------LRARME-------------EMGSRTRDR 246
E LR ++E + R D
Sbjct: 1295 ESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDL 1354
Query: 247 LDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPL-----VEDMQRQWAGLVEKV 301
L E E+ EV+A+L ++ AE Q R+K + +ED +++ A +++
Sbjct: 1355 LREQYEEEQEVKAELHRTLSKV--NAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEA 1412
Query: 302 QAAVGTSAA 310
A+G + A
Sbjct: 1413 AEAMGVANA 1421
Score = 30.8 bits (68), Expect = 1.7
Identities = 63/289 (21%), Positives = 121/289 (41%), Gaps = 45/289 (15%)
Query: 21 EQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRA 80
E + + +L Q + W + G F L + L Q+ E S T+++
Sbjct: 1270 EATAKLDKVTQLANDLAAQKTKLWSES-GEFLRRLEEKEALINQLSRE--KSNFTRQIED 1326
Query: 81 LMDETMKELKAYKSELEEQLTPVAEET---RARLSKELQAAQARLGADMEDVCGRLVQYR 137
L + KE K+ +S L L + R + +E Q +A L + V +VQ+R
Sbjct: 1327 LRGQLEKETKS-QSALAHALQKAQRDCDLLREQYEEE-QEVKAELHRTLSKVNAEMVQWR 1384
Query: 138 GEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGA-ERGLSAIR 196
+ + + Q TE+L ++L RL A+ A+ A AR + ER ++
Sbjct: 1385 MKYENNVIQRTEDLE----DAKKELAIRLQEAAE------AMGVANARNASLERARHQLQ 1434
Query: 197 ERLG-PLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVA 255
LG L + G+VR+A AR+++ ++ L + K++
Sbjct: 1435 LELGDALSDLGKVRSAA---------------------ARLDQKQLQSGKALADWKQKHE 1473
Query: 256 EVRAKLEEQAQQIRLQAEAFQARLKSWFEPLV---EDMQRQWAGLVEKV 301
E +A L+ ++++ + +LK+ +E + E ++R+ L E++
Sbjct: 1474 ESQALLDASQKEVQALSTEL-LKLKNTYEESIVGQETLRRENKNLQEEI 1521
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 48.5 bits (114), Expect = 8e-06
Identities = 57/239 (23%), Positives = 113/239 (47%), Gaps = 22/239 (9%)
Query: 58 VQTLSEQVQ-EELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQ 116
++ ++E+ + EE +++++T + R L DE ELK +LE L V +E A +K
Sbjct: 925 IKEVTERAEDEEEINAELTAKKRKLEDEC-SELKKDIDDLELTLAKVEKEKHATENKVKN 983
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVR--LASHLRKLRKRLLRDADDLQ 174
+ G D + +L + + +Q Q+ ++L+ + L K + +L + DDL+
Sbjct: 984 LTEEMAGLD--ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE 1041
Query: 175 ------KRLAVYQAGAREGAERGLSAIRERL-------GPLVEQGRVRAATVGSLAGQPL 221
K+L + A+ E L +E + L E+ + + + +L Q
Sbjct: 1042 GSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNL--QSK 1099
Query: 222 QERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
E QA G +L+ +++E+ +R + +E++ + A RAK E+Q + + E RL+
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERAS-RAKAEKQRSDLSRELEEISERLE 1157
Score = 45.1 bits (105), Expect = 8e-05
Identities = 51/242 (21%), Positives = 108/242 (44%), Gaps = 21/242 (8%)
Query: 53 DYLRWVQTLSEQV-----QEELLSSQVTQELRALMDETMKELKAYKSELEE-----QLTP 102
D LR + L EQ+ + LL +++ +ELRA +++T + K + EL + QL
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEI-EELRATLEQTERSRKIAEQELLDASERVQLLH 1723
Query: 103 VAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQST---EELRVR--LAS 157
+ K+L+ +++ +MED+ + + + + EEL+ ++
Sbjct: 1724 TQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783
Query: 158 HLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLA 217
HL +++K + + DLQ RL + A +G ++ + + R+ L +G V + +
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL--EGEVESEQKRNAE 1841
Query: 218 GQPLQERAQAWGERLRARMEEMGS---RTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEA 274
+ + + L + EE R +D +D+++ +V + + EE +Q
Sbjct: 1842 AVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAK 1901
Query: 275 FQ 276
F+
Sbjct: 1902 FR 1903
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 48.5 bits (114), Expect = 8e-06
Identities = 57/239 (23%), Positives = 113/239 (47%), Gaps = 22/239 (9%)
Query: 58 VQTLSEQVQ-EELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQ 116
++ ++E+ + EE +++++T + R L DE ELK +LE L V +E A +K
Sbjct: 925 IKEVTERAEDEEEINAELTAKKRKLEDEC-SELKKDIDDLELTLAKVEKEKHATENKVKN 983
Query: 117 AAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVR--LASHLRKLRKRLLRDADDLQ 174
+ G D + +L + + +Q Q+ ++L+ + L K + +L + DDL+
Sbjct: 984 LTEEMAGLD--ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLE 1041
Query: 175 ------KRLAVYQAGAREGAERGLSAIRERL-------GPLVEQGRVRAATVGSLAGQPL 221
K+L + A+ E L +E + L E+ + + + +L Q
Sbjct: 1042 GSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNL--QSK 1099
Query: 222 QERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK 280
E QA G +L+ +++E+ +R + +E++ + A RAK E+Q + + E RL+
Sbjct: 1100 IEDEQALGIQLQKKIKELQARIEELEEEIEAERAS-RAKAEKQRSDLSRELEEISERLE 1157
Score = 45.1 bits (105), Expect = 8e-05
Identities = 51/242 (21%), Positives = 108/242 (44%), Gaps = 21/242 (8%)
Query: 53 DYLRWVQTLSEQV-----QEELLSSQVTQELRALMDETMKELKAYKSELEE-----QLTP 102
D LR + L EQ+ + LL +++ +ELRA +++T + K + EL + QL
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEI-EELRATLEQTERSRKIAEQELLDASERVQLLH 1723
Query: 103 VAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQST---EELRVR--LAS 157
+ K+L+ +++ +MED+ + + + + EEL+ ++
Sbjct: 1724 TQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783
Query: 158 HLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLA 217
HL +++K + + DLQ RL + A +G ++ + + R+ L +G V + +
Sbjct: 1784 HLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL--EGEVESEQKRNAE 1841
Query: 218 GQPLQERAQAWGERLRARMEEMGS---RTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEA 274
+ + + L + EE R +D +D+++ +V + + EE +Q
Sbjct: 1842 AVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAK 1901
Query: 275 FQ 276
F+
Sbjct: 1902 FR 1903
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.128 0.360
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,553,201
Number of Sequences: 37866
Number of extensions: 434712
Number of successful extensions: 4612
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 476
Number of HSP's that attempted gapping in prelim test: 3378
Number of HSP's gapped (non-prelim): 1340
length of query: 317
length of database: 18,247,518
effective HSP length: 102
effective length of query: 215
effective length of database: 14,385,186
effective search space: 3092814990
effective search space used: 3092814990
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.