Guide to the Human Genome
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Search of human proteins with 4557239

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo
sapiens]
         (614 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo sa...  1276   0.0  
gi|7710112 acetylcholinesterase isoform E4-E5 precursor [Homo sa...  1186   0.0  
gi|4557351 butyrylcholinesterase precursor [Homo sapiens]             652   0.0  
gi|51593088 neuroligin 3 [Homo sapiens]                               323   3e-88
gi|31317256 X-linked neuroligin 4 [Homo sapiens]                      319   4e-87
gi|24308209 X-linked neuroligin 4 [Homo sapiens]                      319   4e-87
gi|7662470 neuroligin 1 [Homo sapiens]                                314   1e-85
gi|40538788 neuroligin 4, Y-linked [Homo sapiens]                     311   9e-85
gi|30840978 neuroligin 2 [Homo sapiens]                               301   1e-81
gi|37622885 carboxylesterase 2 isoform 1 [Homo sapiens]               289   5e-78
gi|219521907 carboxylesterase 7 isoform 1 [Homo sapiens]              284   2e-76
gi|37622887 carboxylesterase 2 isoform 2 [Homo sapiens]               279   6e-75
gi|148536848 carboxyl ester lipase precursor [Homo sapiens]           265   7e-71
gi|33563374 carboxylesterase 3 [Homo sapiens]                         264   2e-70
gi|21450749 carboxylesterase 7 isoform 2 [Homo sapiens]               256   3e-68
gi|115529439 carboxylesterase 8 (putative) [Homo sapiens]             251   2e-66
gi|68508967 carboxylesterase 1 isoform a precursor [Homo sapiens]     250   2e-66
gi|68508965 carboxylesterase 1 isoform b precursor [Homo sapiens]     249   4e-66
gi|68508957 carboxylesterase 1 isoform c precursor [Homo sapiens]     247   3e-65
gi|55770862 thyroglobulin [Homo sapiens]                              237   3e-62
gi|169216018 PREDICTED: similar to hCG40360 [Homo sapiens]            118   1e-26
gi|169215613 PREDICTED: similar to hCG40360 [Homo sapiens]            118   1e-26
gi|239752162 PREDICTED: similar to hCG40360 [Homo sapiens]             82   1e-15
gi|68299767 arylacetamide deacetylase [Homo sapiens]                   40   0.006
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]         33   0.59 
gi|206597554 arylacetamide deacetylase-like 2 [Homo sapiens]           33   0.77 
gi|169166139 PREDICTED: similar to predicted protein [Homo sapiens]    33   1.0  
gi|169165130 PREDICTED: hypothetical protein [Homo sapiens]            33   1.0  
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H...    31   2.9  
gi|30179903 SRY (sex determining region Y)-box 8 [Homo sapiens]        31   3.8  

>gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo
           sapiens]
          Length = 614

 Score = 1276 bits (3303), Expect = 0.0
 Identities = 614/614 (100%), Positives = 614/614 (100%)

Query: 1   MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV 60
           MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
Sbjct: 1   MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV 60

Query: 61  SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN 120
           SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
Sbjct: 61  SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN 120

Query: 121 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM 180
           RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
Sbjct: 121 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM 180

Query: 181 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV 240
           NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
Sbjct: 181 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV 240

Query: 241 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL 300
           GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
Sbjct: 241 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL 300

Query: 301 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG 360
           VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
Sbjct: 301 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG 360

Query: 361 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420
           VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
Sbjct: 361 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420

Query: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480
           DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
Sbjct: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480

Query: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540
           EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
Sbjct: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540

Query: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN 600
           YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
Sbjct: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN 600

Query: 601 QFDHYSKQDRCSDL 614
           QFDHYSKQDRCSDL
Sbjct: 601 QFDHYSKQDRCSDL 614


>gi|7710112 acetylcholinesterase isoform E4-E5 precursor [Homo
           sapiens]
          Length = 617

 Score = 1186 bits (3069), Expect = 0.0
 Identities = 574/574 (100%), Positives = 574/574 (100%)

Query: 1   MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV 60
           MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV
Sbjct: 1   MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV 60

Query: 61  SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN 120
           SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN
Sbjct: 61  SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN 120

Query: 121 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM 180
           RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM
Sbjct: 121 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM 180

Query: 181 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV 240
           NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV
Sbjct: 181 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV 240

Query: 241 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL 300
           GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL
Sbjct: 241 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL 300

Query: 301 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG 360
           VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG
Sbjct: 301 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG 360

Query: 361 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420
           VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE
Sbjct: 361 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420

Query: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480
           DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY
Sbjct: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480

Query: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540
           EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ
Sbjct: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540

Query: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSAT 574
           YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSAT
Sbjct: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSAT 574


>gi|4557351 butyrylcholinesterase precursor [Homo sapiens]
          Length = 602

 Score =  652 bits (1683), Expect = 0.0
 Identities = 312/596 (52%), Positives = 417/596 (69%), Gaps = 11/596 (1%)

Query: 20  LLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFL 79
           LLL +L   +G    ED ++++  + G++RG+ L   GG V+AFLGIP+A+PP+G  RF 
Sbjct: 17  LLLCML---IGKSHTED-DIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFK 72

Query: 80  PPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRP 139
            P+    WS + +AT + + C Q +D  +PGF G+EMWNPN +LSEDCLYLNVW P P+P
Sbjct: 73  KPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKP 132

Query: 140 TSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAP 199
            + T VL+WIYGGGF +G SSL VYDG+FL + ER ++VSMNYRVGA GFLALPG+ EAP
Sbjct: 133 KNAT-VLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAP 191

Query: 200 GNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQ 259
           GN+GL DQ+LALQWVQ+N+AAFGG+P SVTLFGESAGAASV +HLLSP S  LF RA+LQ
Sbjct: 192 GNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQ 251

Query: 260 SGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHV 319
           SG+ N PWA   + EAR R   LA L GC    +  N+TE++ CLR +  Q ++ +E  V
Sbjct: 252 SGSFNAPWAVTSLYEARNRTLNLAKLTGC----SRENETEIIKCLRNKDPQEILLNEAFV 307

Query: 320 LPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSK 379
           +P  +    +F P VDGDFL+D P+ L+  G F   Q+LVGV KDEG+ FLVYGAPGFSK
Sbjct: 308 VPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSK 367

Query: 380 DNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVV 439
           DN S+I+R EF  G+++  P VS+   E+++ HYTDW+  + P   REAL DVVGD+N +
Sbjct: 368 DNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFI 427

Query: 440 CPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAE 499
           CP  +   + +  G   + Y FEHR+S L WP WMGV HGYEIEF+FG+PL+   NYT  
Sbjct: 428 CPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKA 487

Query: 500 EKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQA 559
           E+I ++ +++ WANFA+ G+PNE ++  +  WP + +  Q+Y++L+     +   LRAQ 
Sbjct: 488 EEILSRSIVKRWANFAKYGNPNETQN-NSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQ 546

Query: 560 CAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHY-SKQDRCSDL 614
           C FW  F PK+L  T  +DEAE +WKA FHRW++YM+ WKNQF+ Y SK++ C  L
Sbjct: 547 CRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL 602


>gi|51593088 neuroligin 3 [Homo sapiens]
          Length = 828

 Score =  323 bits (828), Expect = 3e-88
 Identities = 216/630 (34%), Positives = 304/630 (48%), Gaps = 77/630 (12%)

Query: 3   PPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPG---GP 59
           PP   L         L L LW L   + A  +  A   V    G+LRG R+  P    GP
Sbjct: 7   PPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPT-VNTHFGKLRGARVPLPSEILGP 65

Query: 60  VSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNP 119
           V  +LG+P+A PP+G +RFLPPEP   WSG+ +AT F  VC Q + T  P       +  
Sbjct: 66  VDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTA 125

Query: 120 N--------RELSEDCLYLNVWTPYP-----------------------RPTSPTPVLVW 148
           N        +E +EDCLYLNV+ P                         R +   PV+V+
Sbjct: 126 NLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVY 185

Query: 149 IYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQR 208
           I+GG +  G  ++   DG  L      +++++NYRVG  GFL+  G + A GN GLLDQ 
Sbjct: 186 IHGGSYMEGTGNM--IDGSILASYGNVIVITLNYRVGVLGFLST-GDQAAKGNYGLLDQI 242

Query: 209 LALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWA 268
            AL+WV EN+A FGGDP  +T+FG   GA+ V +  LS  S GLF RA++QSG+    WA
Sbjct: 243 QALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWA 302

Query: 269 TVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRF 328
                +  +  + LA  VGC    T     ++V CLR + A+ LV  +     Q + +  
Sbjct: 303 V--NYQPVKYTSLLADKVGCNVLDT----VDMVDCLRQKSAKELVEQD----IQPARYHV 352

Query: 329 SFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRA 388
           +F PV+DGD + D PE L+  G+F    +++GV + EG  F V G      D E  +S  
Sbjct: 353 AFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKF-VEGV----VDPEDGVSGT 407

Query: 389 EFLAGVR------VGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPV 442
           +F   V        G P+  D   E +   YTDW   ++P   R+ L  +  DH  V P 
Sbjct: 408 DFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPS 467

Query: 443 AQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPL-DPSR----NYT 497
              A   A  G+  Y Y F H   +L  P W    HG E+ ++FG+P+  P+     N++
Sbjct: 468 VVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFS 527

Query: 498 AEEKIFAQRLMRYWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLD 545
             + + +  +M YW NFA+TGDPN+  P+D K             W  Y    Q Y+ + 
Sbjct: 528 KNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIG 587

Query: 546 LRPLEVRRGLRAQACAFWNRFLPKLLSATD 575
           L+P  VR   RA   AFW   +P L +  D
Sbjct: 588 LKP-RVRDHYRATKVAFWKHLVPHLYNLHD 616


>gi|31317256 X-linked neuroligin 4 [Homo sapiens]
          Length = 816

 Score =  319 bits (818), Expect = 4e-87
 Identities = 208/613 (33%), Positives = 307/613 (50%), Gaps = 59/613 (9%)

Query: 1   MRPPQCLLHTPSLASPLLLLL-----LWLLGGGVGAE--GREDAELLVTVRGGRLRGIRL 53
           M  PQ LL  P L +P+ ++L     LWL    +       +    +V    G++RG+R 
Sbjct: 1   MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60

Query: 54  KTPG---GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPG 110
             P    GPV  +LG+P+A PP G RRF PPEP   W+G+ + T F +VC Q++D     
Sbjct: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120

Query: 111 FEGTEMWNPN---------RELSEDCLYLNVWTPYPRP----TSPTPVLVWIYGGGFYSG 157
            +   +W            ++ +EDCLYLN++ P         S  PV+V+I+GG +  G
Sbjct: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180

Query: 158 ASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQEN 217
             ++   DG  L      +++++NYR+G  GFL+  G + A GN GLLDQ  AL+W++EN
Sbjct: 181 TGNM--IDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEEN 237

Query: 218 VAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARR 277
           V AFGGDP  VT+FG  AGA+ V +  LS  S GLF +A++QSG     WA     +  +
Sbjct: 238 VGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAV--NYQPAK 295

Query: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337
               LA  VGC    T    T++V CLR +  + L+     + P  + +  +F PV+DGD
Sbjct: 296 YTRILADKVGCNMLDT----TDMVECLRNKNYKELIQQT--ITP--ATYHIAFGPVIDGD 347

Query: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYF---LVYGAPGFSKDNESLISRAEFLAGV 394
            + D P+ L+  G+F    +++GV + EG  F   +V    G +  N+   S + F+  +
Sbjct: 348 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVT-PNDFDFSVSNFVDNL 406

Query: 395 RVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGA 454
             G P+  D   E +   YTDW   E+P   R+ L  +  DH  V P    A   A  G+
Sbjct: 407 -YGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGS 465

Query: 455 RVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDP-----SRNYTAEEKIFAQRLMR 509
             Y Y F H   +   P W    HG E+ ++FGIP+       S N++  + + +  +M 
Sbjct: 466 PTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMT 525

Query: 510 YWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRGLRA 557
           YW NFA+TGDPN+  P+D K             W  Y    Q Y+ + L+P  VR   RA
Sbjct: 526 YWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-RVRDHYRA 584

Query: 558 QACAFWNRFLPKL 570
              AFW   +P L
Sbjct: 585 TKVAFWLELVPHL 597


>gi|24308209 X-linked neuroligin 4 [Homo sapiens]
          Length = 816

 Score =  319 bits (818), Expect = 4e-87
 Identities = 208/613 (33%), Positives = 307/613 (50%), Gaps = 59/613 (9%)

Query: 1   MRPPQCLLHTPSLASPLLLLL-----LWLLGGGVGAE--GREDAELLVTVRGGRLRGIRL 53
           M  PQ LL  P L +P+ ++L     LWL    +       +    +V    G++RG+R 
Sbjct: 1   MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60

Query: 54  KTPG---GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPG 110
             P    GPV  +LG+P+A PP G RRF PPEP   W+G+ + T F +VC Q++D     
Sbjct: 61  PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120

Query: 111 FEGTEMWNPN---------RELSEDCLYLNVWTPYPRP----TSPTPVLVWIYGGGFYSG 157
            +   +W            ++ +EDCLYLN++ P         S  PV+V+I+GG +  G
Sbjct: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180

Query: 158 ASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQEN 217
             ++   DG  L      +++++NYR+G  GFL+  G + A GN GLLDQ  AL+W++EN
Sbjct: 181 TGNM--IDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEEN 237

Query: 218 VAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARR 277
           V AFGGDP  VT+FG  AGA+ V +  LS  S GLF +A++QSG     WA     +  +
Sbjct: 238 VGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAV--NYQPAK 295

Query: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337
               LA  VGC    T    T++V CLR +  + L+     + P  + +  +F PV+DGD
Sbjct: 296 YTRILADKVGCNMLDT----TDMVECLRNKNYKELIQQT--ITP--ATYHIAFGPVIDGD 347

Query: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYF---LVYGAPGFSKDNESLISRAEFLAGV 394
            + D P+ L+  G+F    +++GV + EG  F   +V    G +  N+   S + F+  +
Sbjct: 348 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVT-PNDFDFSVSNFVDNL 406

Query: 395 RVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGA 454
             G P+  D   E +   YTDW   E+P   R+ L  +  DH  V P    A   A  G+
Sbjct: 407 -YGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGS 465

Query: 455 RVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDP-----SRNYTAEEKIFAQRLMR 509
             Y Y F H   +   P W    HG E+ ++FGIP+       S N++  + + +  +M 
Sbjct: 466 PTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMT 525

Query: 510 YWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRGLRA 557
           YW NFA+TGDPN+  P+D K             W  Y    Q Y+ + L+P  VR   RA
Sbjct: 526 YWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-RVRDHYRA 584

Query: 558 QACAFWNRFLPKL 570
              AFW   +P L
Sbjct: 585 TKVAFWLELVPHL 597


>gi|7662470 neuroligin 1 [Homo sapiens]
          Length = 823

 Score =  314 bits (805), Expect = 1e-85
 Identities = 211/621 (33%), Positives = 306/621 (49%), Gaps = 72/621 (11%)

Query: 6   CLLHTPSLASPLLLLLLWLL--GGGVGAEGREDAELLVTVRGGRLRGIRLKTPG---GPV 60
           CL+H   L +PL L +L  L   G V ++  +D + LV    G++RGI+ +      GPV
Sbjct: 19  CLVHR-GLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPV 77

Query: 61  SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQ-YVDTLYPGFEGTEMWNP 119
             FLG+P+A PP G RRF PPEP  PWS + +AT F  VC Q  +D   P      +W  
Sbjct: 78  IQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVM-LPVWFT 136

Query: 120 N---------RELSEDCLYLNVWTPYPRPT----SPTPVLVWIYGGGFYSGASSLDVYDG 166
           N         ++ SEDCLYLN++ P          P PV+V+I+GG +  G  +L  YDG
Sbjct: 137 NNLDVVSSYVQDQSEDCLYLNIYVPTEDDIRDSGGPKPVMVYIHGGSYMEGTGNL--YDG 194

Query: 167 RFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPT 226
             L      +++++NYR+G  GFL+  G + A GN GLLD   AL+W  EN+  FGGDP 
Sbjct: 195 SVLASYGNVIVITVNYRLGVLGFLS-TGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPL 253

Query: 227 SVTLFGESAGAASVGMHLLSPPS---------RGLFHRAVLQSGAPNGPWATVGMGEARR 277
            +T+FG  AG + V +  LS  S         +GLF RA+ QSG     WA     +  +
Sbjct: 254 RITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAV--SFQPAK 311

Query: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337
            A  LA  VGC    T     ELV CL+ +P + LV+ +     Q + +  +F PV+DGD
Sbjct: 312 YARMLATKVGCNVSDT----VELVECLQKKPYKELVDQD----IQPARYHIAFGPVIDGD 363

Query: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVR-- 395
            + D P+ L+  G+F    +++GV + EG  F+         D++  IS ++F   V   
Sbjct: 364 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVEN-----IVDSDDGISASDFDFAVSNF 418

Query: 396 ----VGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAA 451
                G P+  D+  E +   YTDW    +P   R+ L  +  DH  V P    A   + 
Sbjct: 419 VDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSN 478

Query: 452 QGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIP-LDPSR----NYTAEEKIFAQR 506
            G+  Y Y F H   T   P W    HG E+ ++ GIP + P+     N++  + + +  
Sbjct: 479 FGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAV 538

Query: 507 LMRYWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRG 554
           +M YW NFA+TGDPN+  P+D K             W  Y+   Q Y+ + L+P  V+  
Sbjct: 539 VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKP-RVKEH 597

Query: 555 LRAQACAFWNRFLPKLLSATD 575
            RA     W   +P L +  D
Sbjct: 598 YRANKVNLWLELVPHLHNLND 618


>gi|40538788 neuroligin 4, Y-linked [Homo sapiens]
          Length = 816

 Score =  311 bits (798), Expect = 9e-85
 Identities = 203/613 (33%), Positives = 306/613 (49%), Gaps = 59/613 (9%)

Query: 1   MRPPQCLLHTPSLASPLLLLL-----LWLLGGGVGAE--GREDAELLVTVRGGRLRGIRL 53
           M  PQ LL  P L + + ++L     LW+    +       +    +V    G+++G+R 
Sbjct: 1   MLRPQGLLWLPLLFTSVCVMLNSNVLLWITALAIKFTLIDSQAQYPVVNTNYGKIQGLRT 60

Query: 54  KTPG---GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPG 110
             P    GPV  +LG+P+A PP G RRF PPE    W+G+ +AT F +VC Q++D  +  
Sbjct: 61  PLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHLDERFLL 120

Query: 111 FEGTEMWNPN---------RELSEDCLYLNVWTPYP----RPTSPTPVLVWIYGGGFYSG 157
            +   +W            ++ +EDCLYLN++ P         S  PV+V+I+GG +  G
Sbjct: 121 HDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDDIHEQNSKKPVMVYIHGGSYMEG 180

Query: 158 ASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQEN 217
             ++   DG  L      +++++N R+G  GFL+  G + A GN GLLDQ  AL+W++EN
Sbjct: 181 TGNM--IDGSILASYGNVIVITINCRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEEN 237

Query: 218 VAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARR 277
           V AFGGDP  VT+FG  AGA+ V +  LS  S GLF +A++QSG     WA     +  +
Sbjct: 238 VGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAV--NYQPAK 295

Query: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337
               LA  VGC    T    T++V CL+ +  + L+     + P  + +  +F PV+DGD
Sbjct: 296 YTRILADKVGCNMLDT----TDMVECLKNKNYKELIQQT--ITP--ATYHIAFGPVIDGD 347

Query: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYF---LVYGAPGFSKDNESLISRAEFLAGV 394
            + D P+ L+  G+F    +++GV + EG  F   +V    G +  N+   S + F+  +
Sbjct: 348 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVT-PNDFDFSVSNFVDNL 406

Query: 395 RVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGA 454
             G P+  D   E +   YTDW   E+P   R+ L  +  DH  V P    A   A  G+
Sbjct: 407 -YGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGS 465

Query: 455 RVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDP-----SRNYTAEEKIFAQRLMR 509
             Y Y F H   +   P W    HG E+ ++FGIP+       S N++  + + +  +M 
Sbjct: 466 PTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMT 525

Query: 510 YWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRGLRA 557
           YW NFA+TGDPN+  P+D K             W  Y    Q Y+ + L+P  VR   RA
Sbjct: 526 YWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-RVRDHYRA 584

Query: 558 QACAFWNRFLPKL 570
              AFW   +P L
Sbjct: 585 TKVAFWLELVPHL 597


>gi|30840978 neuroligin 2 [Homo sapiens]
          Length = 835

 Score =  301 bits (771), Expect = 1e-81
 Identities = 198/599 (33%), Positives = 292/599 (48%), Gaps = 74/599 (12%)

Query: 26  GGGVGAEGREDAELLVTVRGGRLRGIRLKTPG---GPVSAFLGIPFAEPPMGPRRFLPPE 82
           G G+G+ G E   ++ T  G R+RG+R +      GPV  FLG+P+A PP+G RRF PPE
Sbjct: 30  GLGLGSLGEERFPVVNTAYG-RVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPE 88

Query: 83  PKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNREL--------SEDCLYLNVWT 134
               W GV +ATT    C Q +    P       +  N E         SEDCLYLN++ 
Sbjct: 89  APASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYV 148

Query: 135 PYP--------------------RPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAER 174
           P                      R     PV+++++GG +  G  ++  +DG  L     
Sbjct: 149 PTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNM--FDGSVLAAYGN 206

Query: 175 TVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGES 234
            ++ ++NYR+G  GFL+  G + A GN GLLDQ  AL+W+ EN+A FGGDP  +T+FG  
Sbjct: 207 VIVATLNYRLGVLGFLST-GDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSG 265

Query: 235 AGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTG 294
           AGA+ V + +LS  S GLF +A+ QSG     W+     +  +    LA  VGC      
Sbjct: 266 AGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSV--NYQPLKYTRLLAAKVGC----DR 319

Query: 295 GNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHG 354
            +  E V CLR +P++ LV+ +     Q + +  +F PVVDGD + D PE L+  G+F  
Sbjct: 320 EDSAEAVECLRRKPSRELVDQD----VQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLN 375

Query: 355 LQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVR------VGVPQVSDLAAEA 408
             +L+GV + EG  F+   A     ++E  +S + F   V        G P+  D+  E 
Sbjct: 376 YDMLIGVNQGEGLKFVEDSA-----ESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRET 430

Query: 409 VVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTL 468
           +   YTDW   ++    R+ L  +  DH  V P    A   A   + VY Y F H     
Sbjct: 431 IKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAE 490

Query: 469 SWPLWMGVPHGYEIEFIFGIPLDPSR-----NYTAEEKIFAQRLMRYWANFARTGDPNE- 522
             P W    HG E+ ++FG+P+  +      N++  + + +  +M YW NFA+TGDPN+ 
Sbjct: 491 GRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP 550

Query: 523 -PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKL 570
            P+D K             W  + +  +QY+ + L+P  VR   RA   AFW   +P L
Sbjct: 551 VPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKP-RVRDNYRANKVAFWLELVPHL 608


>gi|37622885 carboxylesterase 2 isoform 1 [Homo sapiens]
          Length = 623

 Score =  289 bits (740), Expect = 5e-78
 Identities = 201/582 (34%), Positives = 300/582 (51%), Gaps = 53/582 (9%)

Query: 12  SLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFA 69
           ++A  LLLLL       V  +G++ A  + T   G++ G  + +K     V  FLGIPFA
Sbjct: 76  AVACGLLLLL-------VRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFA 128

Query: 70  EPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGT-EMWNPNRELSEDCL 128
           +PP+GP RF PPEP + WSGV D TT  ++C Q +  +   F     M  P+  +SEDCL
Sbjct: 129 KPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCL 188

Query: 129 YLNVWTP-YPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAF 187
           YL+++TP +    S  PV+VWI+GG    G +SL  YDG  L   E  V+V + YR+G  
Sbjct: 189 YLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASL--YDGSMLAALENVVVVIIQYRLGVL 246

Query: 188 GFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSP 247
           GF +  G + A GN G LDQ  AL+WVQ+N+A FGG+P  VT+FGESAG  SV   ++SP
Sbjct: 247 GFFST-GDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSP 305

Query: 248 PSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTR 307
            S+GLFH A+++SG    P       +    +T +A+L  C       +   LV CLR +
Sbjct: 306 ISQGLFHGAIMESGVALLPGLIASSADV--ISTVVANLSACDQ----VDSEALVGCLRGK 359

Query: 308 PAQ--VLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDE 365
             +  + +N  + ++P           VVDG FL   P+ L+ + DF  +  +VGV  +E
Sbjct: 360 SKEEILAINKPFKMIP----------GVVDGVFLPRHPQELLASADFQPVPSIVGVNNNE 409

Query: 366 GSYFL-----VYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420
             + +     +Y       D E+  +  + +  + +  P   DL  E  +          
Sbjct: 410 FGWLIPKVMRIYDTQK-EMDREASQAALQKMLTLLMLPPTFGDLLREEYI------GDNG 462

Query: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGVPH 478
           DP  L+    +++ D   V P  Q+A       A VY Y F+H+ S L    P  M   H
Sbjct: 463 DPQTLQAQFQEMMADSMFVIPALQVA-HFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADH 521

Query: 479 GYEIEFIFGIPLDPSR-NYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAG 537
           G E+ F+F      +   +T EE+  ++++M+YWANFAR G+PN       P WP +   
Sbjct: 522 GDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPN---GEGLPHWPLFDQ- 577

Query: 538 AQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDE 579
            +QY+ L+L+P  V R L+A    FW + LP+ +   +  +E
Sbjct: 578 EEQYLQLNLQP-AVGRALKAHRLQFWKKALPQKIQELEEPEE 618


>gi|219521907 carboxylesterase 7 isoform 1 [Homo sapiens]
          Length = 575

 Score =  284 bits (726), Expect = 2e-76
 Identities = 200/578 (34%), Positives = 298/578 (51%), Gaps = 52/578 (8%)

Query: 17  LLLLLLWLLGG---GVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV--SAFLGIPFAEP 71
           +L+  +W+L     G  AEG +        R G ++G ++   G PV  + FLG+PFA P
Sbjct: 11  ILIWAIWVLAAPTKGPSAEGPQR-----NTRLGWIQGKQVTVLGSPVPVNVFLGVPFAAP 65

Query: 72  PMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLN 131
           P+G  RF  P+P  PW  + +AT++ ++C Q  + L       ++  P   +SEDCLYLN
Sbjct: 66  PLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKFGVSEDCLYLN 125

Query: 132 VWTPYPRPT-SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFL 190
           ++ P    T S  PVLVW  GG F +G++S  ++DG  L   E  ++V + YR+G FGF 
Sbjct: 126 IYAPAHADTGSKLPVLVWFPGGAFKTGSAS--IFDGSALAAYEDVLVVVVQYRLGIFGFF 183

Query: 191 ALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSR 250
                + APGN    DQ  AL WVQ+N+  FGGDP+SVT+FGESAGA SV   +LSP ++
Sbjct: 184 TT-WDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAK 242

Query: 251 GLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTE-LVACLRTRPA 309
           GLFH+A+++SG    P+      E       +AH       G   +D+E L+ CLRT+P+
Sbjct: 243 GLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFC-----GNNASDSEALLRCLRTKPS 297

Query: 310 QVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYF 369
           + L+      L Q++    SF  VVDG F  + P  L++   F  +  ++GV   E  + 
Sbjct: 298 KELL-----TLSQKTK---SFTRVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNHECGFL 349

Query: 370 L-VYGAPG-FSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDP-ARLR 426
           L +  AP   S  N+SL      +  +    PQ   L A        ++ H +     +R
Sbjct: 350 LPMKEAPEILSGSNKSL--ALHLIQNILHIPPQYLHLVA-------NEYFHDKHSLTEIR 400

Query: 427 EALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTL--SWPLWMGVPHGYEIEF 484
           ++L D++GD   V P    A      GA VY Y F HR      + P ++   H  E+ F
Sbjct: 401 DSLLDLLGDVFFVVPALITARYHRDAGAPVYFYEFRHRPQCFEDTKPAFVKADHADEVRF 460

Query: 485 IFG-----IPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQ 539
           +FG       +      T EEK+ ++++M+YWA FARTG+PN         WP Y    +
Sbjct: 461 VFGGAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPN---GNDLSLWPAYNL-TE 516

Query: 540 QYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTL 577
           QY+ LDL  + + + L+     FW   +P +LSA+D L
Sbjct: 517 QYLQLDLN-MSLGQRLKEPRVDFWTSTIPLILSASDML 553


>gi|37622887 carboxylesterase 2 isoform 2 [Homo sapiens]
          Length = 607

 Score =  279 bits (713), Expect = 6e-75
 Identities = 196/579 (33%), Positives = 296/579 (51%), Gaps = 63/579 (10%)

Query: 12  SLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFA 69
           ++A  LLLLL       V  +G++ A  + T   G++ G  + +K     V  FLGIPFA
Sbjct: 76  AVACGLLLLL-------VRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFA 128

Query: 70  EPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGT-EMWNPNRELSEDCL 128
           +PP+GP RF PPEP + WSGV D TT  ++C Q +  +   F     M  P+  +SEDCL
Sbjct: 129 KPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCL 188

Query: 129 YLNVWTP-YPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAF 187
           YL+++TP +    S  PV+VWI+GG    G +SL  YDG  L   E  V+V + YR+G  
Sbjct: 189 YLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASL--YDGSMLAALENVVVVIIQYRLGVL 246

Query: 188 GFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSP 247
           GF +  G + A GN G LDQ  AL+WVQ+N+A FGG+P  VT+FGESAG  SV   ++SP
Sbjct: 247 GFFST-GDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSP 305

Query: 248 PSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTR 307
            S+GLFH A+++SG    P       +    +T +A+L  C       +   LV CLR +
Sbjct: 306 ISQGLFHGAIMESGVALLPGLIASSADV--ISTVVANLSACDQ----VDSEALVGCLRGK 359

Query: 308 PAQ--VLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDE 365
             +  + +N  + ++P           VVDG FL   P+ L+ + DF  +  +VGV  +E
Sbjct: 360 SKEEILAINKPFKMIP----------GVVDGVFLPRHPQELLASADFQPVPSIVGVNNNE 409

Query: 366 GSYFL-----VYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420
             + +     +Y       D E+  +  + +  + +  P   DL  E  +          
Sbjct: 410 FGWLIPKVMRIYDTQK-EMDREASQAALQKMLTLLMLPPTFGDLLREEYI------GDNG 462

Query: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480
           DP  L+    +++ D   V P  Q+A       A VY Y F+H+    SW   +  PH  
Sbjct: 463 DPQTLQAQFQEMMADSMFVIPALQVA-HFQCSRAPVYFYEFQHQP---SWLKNIRPPH-M 517

Query: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540
           + + +          +T EE+  ++++M+YWANFAR G+PN       P WP +    +Q
Sbjct: 518 KADHV---------KFTEEEEQLSRKMMKYWANFARNGNPN---GEGLPHWPLFDQ-EEQ 564

Query: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDE 579
           Y+ L+L+P  V R L+A    FW + LP+ +   +  +E
Sbjct: 565 YLQLNLQP-AVGRALKAHRLQFWKKALPQKIQELEEPEE 602


>gi|148536848 carboxyl ester lipase precursor [Homo sapiens]
          Length = 756

 Score =  265 bits (678), Expect = 7e-71
 Identities = 181/561 (32%), Positives = 261/561 (46%), Gaps = 58/561 (10%)

Query: 41  VTVRGGRLRGIRLKTP--GGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQS 98
           V   GG + G+  K    G  V  F GIPFA P         P+P   W G + A  F+ 
Sbjct: 29  VYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALEN---PQPHPGWQGTLKAKNFKK 85

Query: 99  VCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRP--TSPTPVLVWIYGGGFYS 156
            C Q   T    +             EDCLYLN+W P  R   +   PV++WIYGG F  
Sbjct: 86  RCLQATITQDSTYG-----------DEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLM 134

Query: 157 G----ASSLD--VYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLA 210
           G    A+ L+  +YDG  +      ++V+ NYRVG  GFL+  G    PGN GL DQ +A
Sbjct: 135 GSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLST-GDANLPGNYGLRDQHMA 193

Query: 211 LQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATV 270
           + WV+ N+AAFGGDP ++TLFGESAG ASV +  LSP ++GL  RA+ QSG    PW  V
Sbjct: 194 IAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPW--V 251

Query: 271 GMGEARRRATQLAHLVGCPPGGTGGNDTELVACLR-TRPAQVLVNHEWHV--LPQESVFR 327
                   A ++A  VGCP     G+   +  CL+ T P  + + ++  +  L    +  
Sbjct: 252 IQKNPLFWAKKVAEKVGCPV----GDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHY 307

Query: 328 FSFVPVVDGDFLSDTPEAL-INAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNE---- 382
             FVPV+DGDF+   P  L  NA D   +  + G    +G  F     P  +K N+    
Sbjct: 308 VGFVPVIDGDFIPADPINLYANAAD---IDYIAGTNNMDGHIFASIDMPAINKGNKKVTE 364

Query: 383 ----SLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNV 438
                L+S      G+R G     D+  E+       W         ++ + D   D   
Sbjct: 365 EDFYKLVSEFTITKGLR-GAKTTFDVYTES-------WAQDPSQENKKKTVVDFETDVLF 416

Query: 439 VCP--VAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNY 496
           + P  +A    R  A+ A+ YAY+F H +    +P W+G  H  +I+++FG P      Y
Sbjct: 417 LVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGY 476

Query: 497 TAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSL--DLRPLEVRRG 554
             +++  ++ ++ YW NFA+TGDPN         W PYT     Y+ +   +    ++R 
Sbjct: 477 RPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRS 536

Query: 555 LRAQACAFWNRFLPKLLSATD 575
           LR     +W      L + TD
Sbjct: 537 LRTNFLRYWTLTYLALPTVTD 557


>gi|33563374 carboxylesterase 3 [Homo sapiens]
          Length = 571

 Score =  264 bits (675), Expect = 2e-70
 Identities = 191/560 (34%), Positives = 280/560 (50%), Gaps = 41/560 (7%)

Query: 24  LLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGP--VSAFLGIPFAEPPMGPRRFLPP 81
           LL     A G E A+  V    GR+RG ++   G    V+ FLGIPFA+PP+GP RF  P
Sbjct: 19  LLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAP 78

Query: 82  EPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT- 140
            P QPW GV DA+T   +C Q V+++               +SEDCL LNV++P   P  
Sbjct: 79  HPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAG 138

Query: 141 SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPG 200
           S  PV+VW++GG   +GA++   YDG  L      V+V++ YR+G  GF +  G   APG
Sbjct: 139 SGRPVMVWVHGGALITGAATS--YDGSALAAYGDVVVVTVQYRLGVLGFFST-GDEHAPG 195

Query: 201 NVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQS 260
           N G LD   AL+WVQEN+A FGGD   VT+FG SAG + +   +LSP + GLFHRA+ QS
Sbjct: 196 NQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQS 255

Query: 261 GAPNGPWATVGMGEAR--RRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWH 318
           G    P    G+ ++     A ++A+ + C    +  +  E+V CL+ +  + LV     
Sbjct: 256 GVITTP----GIIDSHPWPLAQKIANTLAC----SSSSPAEMVQCLQQKEGEELV----- 302

Query: 319 VLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFS 378
               + +    +   VDG     +P+ L+    FH +  L+GV   E S+ +  G     
Sbjct: 303 --LSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRG--WGL 358

Query: 379 KDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLR-EALSDVVGDHN 437
            D    +SR + LA +   V    D+  E +     ++L     A+ + +A  + +GD  
Sbjct: 359 LDTMEQMSREDMLA-ISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVF 417

Query: 438 VVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGVPHGYEIEFIFGIP--LDPS 493
           +  P    +  L   G+ V+ Y F+HR S+ +   P W+   HG E  F+FG P  +D S
Sbjct: 418 INVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDES 477

Query: 494 RNY-----TAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRP 548
                   T EEK  +  +M  W +FARTGDPN       P WP +   A+QY+ ++  P
Sbjct: 478 SRLAFPEATEEEKQLSLTMMAQWTHFARTGDPN---SKALPPWPQFNQ-AEQYLEINPVP 533

Query: 549 LEVRRGLRAQACAFWNRFLP 568
               +  R     FW+  LP
Sbjct: 534 -RAGQKFREAWMQFWSETLP 552


>gi|21450749 carboxylesterase 7 isoform 2 [Homo sapiens]
          Length = 525

 Score =  256 bits (655), Expect = 3e-68
 Identities = 189/571 (33%), Positives = 283/571 (49%), Gaps = 88/571 (15%)

Query: 17  LLLLLLWLLGG---GVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV--SAFLGIPFAEP 71
           +L+  +W+L     G  AEG +        R G ++G ++   G PV  + FLG+PFA P
Sbjct: 11  ILIWAIWVLAAPTKGPSAEGPQR-----NTRLGWIQGKQVTVLGSPVPVNVFLGVPFAAP 65

Query: 72  PMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLN 131
           P+G  RF  P+P  PW  + +AT++ ++C Q  + L       ++  P   +SEDCLYLN
Sbjct: 66  PLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKFGVSEDCLYLN 125

Query: 132 VWTPYPRPT-SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFL 190
           ++ P    T S  PVLVW  GG F +G++S  ++DG  L   E  ++V + YR+G FGF 
Sbjct: 126 IYAPAHADTGSKLPVLVWFPGGAFKTGSAS--IFDGSALAAYEDVLVVVVQYRLGIFGFF 183

Query: 191 ALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSR 250
                + APGN    DQ  AL WVQ+N+  FGGDP+SVT+FGESAGA SV   +LSP ++
Sbjct: 184 TT-WDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAK 242

Query: 251 GLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTE-LVACLRTRPA 309
           GLFH+A+++SG    P+      E       +AH       G   +D+E L+ CLRT+P+
Sbjct: 243 GLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFC-----GNNASDSEALLRCLRTKPS 297

Query: 310 QVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYF 369
           + L+      L Q++    SF  VVDG F  + P  L++   F  +  ++GV   E  + 
Sbjct: 298 KELL-----TLSQKTK---SFTRVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNHECGFL 349

Query: 370 L-VYGAPG-FSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDP-ARLR 426
           L +  AP   S  N+SL      +  +    PQ   L A        ++ H +     +R
Sbjct: 350 LPMKEAPEILSGSNKSL--ALHLIQNILHIPPQYLHLVA-------NEYFHDKHSLTEIR 400

Query: 427 EALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIF 486
           ++L D++GD   V P A +  R   +GA                                
Sbjct: 401 DSLLDLLGDVFFVVP-ALITARYHREGA-------------------------------- 427

Query: 487 GIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDL 546
                     T EEK+ ++++M+YWA FARTG+PN         WP Y    +QY+ LDL
Sbjct: 428 ----------TEEEKLLSRKMMKYWATFARTGNPN---GNDLSLWPAYNL-TEQYLQLDL 473

Query: 547 RPLEVRRGLRAQACAFWNRFLPKLLSATDTL 577
             + + + L+     FW   +P +LSA+D L
Sbjct: 474 N-MSLGQRLKEPRVDFWTSTIPLILSASDML 503


>gi|115529439 carboxylesterase 8 (putative) [Homo sapiens]
          Length = 491

 Score =  251 bits (640), Expect = 2e-66
 Identities = 186/538 (34%), Positives = 255/538 (47%), Gaps = 105/538 (19%)

Query: 41  VTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVC 100
           V  + G L+G ++     P+  FLG+PF+ PP+G  RF PPEP +PW G+ DATT+   C
Sbjct: 29  VVTKYGTLQGKQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGC 88

Query: 101 YQ----YVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPT-PVLVWIYGGGFY 155
            Q     + ++Y        W      SEDCLYLNV+ P   P  P  PV+VW  GG F 
Sbjct: 89  LQESWGQLASMYVSTRERYKW---LRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFI 145

Query: 156 SGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQ 215
            GA+S   Y+G  L   E+ VLV + +R+G FGFL+   S  A GN GLLDQ  AL+WVQ
Sbjct: 146 VGAASS--YEGSDLAAREKVVLVFLQHRLGIFGFLSTDDSH-ARGNWGLLDQMAALRWVQ 202

Query: 216 ENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEA 275
           EN+AAFGGDP +VTLFG+SAGA S+   ++SP + GLFHRA+ QSG     +        
Sbjct: 203 ENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQSG--TALFRLFITSNP 260

Query: 276 RRRATQLAHLVGCPPGGTGGNDTE-LVACLRTRPAQ--VLVNHEWHVL-------PQESV 325
            + A ++AHL GC       N T+ LV CLR       + V+++   L       P+E +
Sbjct: 261 LKVAKKVAHLAGC-----NHNSTQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPEEII 315

Query: 326 FRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLI 385
           +  S  PVVDG  + D P  L+  G    +  L+GV   E ++ L Y     +K+   L 
Sbjct: 316 WSMS--PVVDGVVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPY---NITKEQVPL- 369

Query: 386 SRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQL 445
                                  VV  Y D ++  D   LR  + D+V D   V    Q 
Sbjct: 370 -----------------------VVEEYLDNVNEHDWKMLRNRMMDIVQDATFVYATLQT 406

Query: 446 AGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQ 505
           A                HR  ++                              +EK  + 
Sbjct: 407 A--------------HYHRGLSM-----------------------------GKEKALSL 423

Query: 506 RLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFW 563
           ++M+YWANFARTG+PN   D   P WP Y    ++Y+ LD     V   L+ +  AFW
Sbjct: 424 QMMKYWANFARTGNPN---DGNLPCWPRYNKD-EKYLQLDF-TTRVGMKLKEKKMAFW 476


>gi|68508967 carboxylesterase 1 isoform a precursor [Homo sapiens]
          Length = 568

 Score =  250 bits (639), Expect = 2e-66
 Identities = 188/574 (32%), Positives = 288/574 (50%), Gaps = 43/574 (7%)

Query: 17  LLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFAEPPMG 74
           L   +L  L       G   +  +V    G++ G  + L+    PV+ FLGIPFA+PP+G
Sbjct: 3   LRAFILATLSASAAWAGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLG 62

Query: 75  PRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRE-----LSEDCLY 129
           P RF PP+P +PWS V +AT++  +C Q       G   +E++   +E     LSEDCLY
Sbjct: 63  PLRFTPPQPAEPWSFVKNATSYPPMCTQDPKA---GQLLSELFTNRKENIPLKLSEDCLY 119

Query: 130 LNVWTPYP-RPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFG 188
           LN++TP      +  PV+VWI+GGG   GA+S   YDG  L   E  V+V++ YR+G +G
Sbjct: 120 LNIYTPADLTKKNRLPVMVWIHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIWG 177

Query: 189 FLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPP 248
           F +  G   + GN G LDQ  AL+WVQ+N+A+FGG+P SVT+FGESAG  SV + +LSP 
Sbjct: 178 FFST-GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPL 236

Query: 249 SRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRP 308
           ++ LFHRA+ +SG        V  G+ +  A Q+A   GC           +V CLR + 
Sbjct: 237 AKNLFHRAISESGVALTS-VLVKKGDVKPLAEQIAITAGCKT----TTSAVMVHCLRQKT 291

Query: 309 AQVLVNHEWHVL---------PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLV 359
            + L+     +          P+ES  +     V+DG  L  TPE L    +FH +  +V
Sbjct: 292 EEELLETTLKMKFLSLDLQGDPRES--QPLLGTVIDGMLLLKTPEELQAERNFHTVPYMV 349

Query: 360 GVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWL-H 418
           G+ K E  + +      +   +E  + +   ++ +    P V  +A E +      +L  
Sbjct: 350 GINKQEFGWLIPMQLMSYPL-SEGQLDQKTAMSLLWKSYPLVC-IAKELIPEATEKYLGG 407

Query: 419 PEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGV 476
            +D  + ++   D++ D     P   +A      GA  Y Y F++R S  S   P  +  
Sbjct: 408 TDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIG 467

Query: 477 PHGYEIEFIFGIPLDPSRNYTAEEKI-FAQRLMRYWANFARTGDPNEPRDPKAPQWPPYT 535
            HG E+  +FG P    +   +EE+I  ++ +M++WANFAR G+PN       P WP Y 
Sbjct: 468 DHGDELFSVFGAPF--LKEGASEEEIRLSKMVMKFWANFARNGNPN---GEGLPHWPEYN 522

Query: 536 AGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPK 569
              + Y+ +     +  + L+ +  AFW     K
Sbjct: 523 Q-KEGYLQIGAN-TQAAQKLKDKEVAFWTNLFAK 554


>gi|68508965 carboxylesterase 1 isoform b precursor [Homo sapiens]
          Length = 567

 Score =  249 bits (637), Expect = 4e-66
 Identities = 186/560 (33%), Positives = 285/560 (50%), Gaps = 43/560 (7%)

Query: 31  AEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWS 88
           A G   +  +V    G++ G  + L+    PV+ FLGIPFA+PP+GP RF PP+P +PWS
Sbjct: 16  AWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWS 75

Query: 89  GVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRE-----LSEDCLYLNVWTPYP-RPTSP 142
            V +AT++  +C Q       G   +E++   +E     LSEDCLYLN++TP      + 
Sbjct: 76  FVKNATSYPPMCTQDPKA---GQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNR 132

Query: 143 TPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNV 202
            PV+VWI+GGG   GA+S   YDG  L   E  V+V++ YR+G +GF +  G   + GN 
Sbjct: 133 LPVMVWIHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIWGFFST-GDEHSRGNW 189

Query: 203 GLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGA 262
           G LDQ  AL+WVQ+N+A+FGG+P SVT+FGESAG  SV + +LSP ++ LFHRA+ +SG 
Sbjct: 190 GHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGV 249

Query: 263 PNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVL-- 320
                  V  G+ +  A Q+A   GC           +V CLR +  + L+     +   
Sbjct: 250 ALTS-VLVKKGDVKPLAEQIAITAGCKT----TTSAVMVHCLRQKTEEELLETTLKMKFL 304

Query: 321 -------PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYG 373
                  P+ES  +     V+DG  L  TPE L    +FH +  +VG+ K E  + +   
Sbjct: 305 SLDLQGDPRES--QPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQ 362

Query: 374 APGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWL-HPEDPARLREALSDV 432
              +   +E  + +   ++ +    P V  +A E +      +L   +D  + ++   D+
Sbjct: 363 LMSYPL-SEGQLDQKTAMSLLWKSYPLVC-IAKELIPEATEKYLGGTDDTVKKKDLFLDL 420

Query: 433 VGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGVPHGYEIEFIFGIPL 490
           + D     P   +A      GA  Y Y F++R S  S   P  +   HG E+  +FG P 
Sbjct: 421 IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF 480

Query: 491 DPSRNYTAEEKI-FAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPL 549
              +   +EE+I  ++ +M++WANFAR G+PN       P WP Y    + Y+ +     
Sbjct: 481 --LKEGASEEEIRLSKMVMKFWANFARNGNPN---GEGLPHWPEYNQ-KEGYLQIGAN-T 533

Query: 550 EVRRGLRAQACAFWNRFLPK 569
           +  + L+ +  AFW     K
Sbjct: 534 QAAQKLKDKEVAFWTNLFAK 553


>gi|68508957 carboxylesterase 1 isoform c precursor [Homo sapiens]
          Length = 566

 Score =  247 bits (630), Expect = 3e-65
 Identities = 187/562 (33%), Positives = 286/562 (50%), Gaps = 48/562 (8%)

Query: 31  AEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWS 88
           A G   +  +V    G++ G  + L+    PV+ FLGIPFA+PP+GP RF PP+P +PWS
Sbjct: 16  AWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWS 75

Query: 89  GVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRE-----LSEDCLYLNVWTPYP-RPTSP 142
            V +AT++  +C Q       G   +E++   +E     LSEDCLYLN++TP      + 
Sbjct: 76  FVKNATSYPPMCTQDPKA---GQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNR 132

Query: 143 TPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNV 202
            PV+VWI+GGG   GA+S   YDG  L   E  V+V++ YR+G +GF +  G   + GN 
Sbjct: 133 LPVMVWIHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIWGFFST-GDEHSRGNW 189

Query: 203 GLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGA 262
           G LDQ  AL+WVQ+N+A+FGG+P SVT+FGESAG  SV + +LSP ++ LFHRA+ +SG 
Sbjct: 190 GHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGV 249

Query: 263 PNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVL-- 320
                  V  G+ +  A Q+A   GC           +V CLR +  + L+     +   
Sbjct: 250 ALTS-VLVKKGDVKPLAEQIAITAGCKT----TTSAVMVHCLRQKTEEELLETTLKMKFL 304

Query: 321 -------PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYF--LV 371
                  P+ES  +     V+DG  L  TPE L    +FH +  +VG+ K E  +   ++
Sbjct: 305 SLDLQGDPRES--QPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPML 362

Query: 372 YGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWL-HPEDPARLREALS 430
              P     +E  + +   ++ +    P V  +A E +      +L   +D  + ++   
Sbjct: 363 MSYP----LSEGQLDQKTAMSLLWKSYPLVC-IAKELIPEATEKYLGGTDDTVKKKDLFL 417

Query: 431 DVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGVPHGYEIEFIFGI 488
           D++ D     P   +A      GA  Y Y F++R S  S   P  +   HG E+  +FG 
Sbjct: 418 DLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGA 477

Query: 489 PLDPSRNYTAEEKI-FAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLR 547
           P    +   +EE+I  ++ +M++WANFAR G+PN       P WP Y    + Y+ +   
Sbjct: 478 PF--LKEGASEEEIRLSKMVMKFWANFARNGNPN---GEGLPHWPEYNQ-KEGYLQIGAN 531

Query: 548 PLEVRRGLRAQACAFWNRFLPK 569
             +  + L+ +  AFW     K
Sbjct: 532 -TQAAQKLKDKEVAFWTNLFAK 552


>gi|55770862 thyroglobulin [Homo sapiens]
          Length = 2768

 Score =  237 bits (604), Expect = 3e-62
 Identities = 171/549 (31%), Positives = 269/549 (48%), Gaps = 48/549 (8%)

Query: 46   GRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVD 105
            GR + I++ T    V  FLG+P+A PP+  RRF  PEP   W+G  DA+  ++ C+Q   
Sbjct: 2211 GRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASCWQ--- 2266

Query: 106  TLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYD 165
                   GT   + +  +SEDCLYLNV+ P     + + VLV+ +       +      D
Sbjct: 2267 ------PGTRT-STSPGVSEDCLYLNVFIPQNVAPNAS-VLVFFHNTMDREESEGWPAID 2318

Query: 166  GRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDP 225
            G FL      ++V+ +YRVG FGFL+  GS E  GN GLLDQ  AL WVQ ++  FGGDP
Sbjct: 2319 GSFLAAVGNLIVVTASYRVGVFGFLS-SGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDP 2377

Query: 226  TSVTLFGESAGAASVGMHLLSPPSRG--LFHRAVLQSGAPNGPWATVGMGEARRRATQLA 283
              V+L  +  GA    +HLL+  +    LF RAVL  G+   P A +    A+++A  LA
Sbjct: 2378 RRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALA 2437

Query: 284  HLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTP 343
              V CP      +  E+V+CLR +PA VL + +  +L     F + + PV+DG FL + P
Sbjct: 2438 KEVSCPM----SSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHY-WGPVIDGHFLREPP 2492

Query: 344  EALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGV-PQVS 402
               +    +  + +L+G  +D+G          F +      S+  F   ++  +  + S
Sbjct: 2493 ARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDS 2552

Query: 403  DLAAEAVVLHYTDWLH-PEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVF 461
            D   EA    Y    H  +D A    AL +   D+ ++CP+  +A   +A   R    VF
Sbjct: 2553 DARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMA---SAWAKRARGNVF 2609

Query: 462  EHRASTLSWPLWMGVPHG-----YEIEFIFGIPLDPS--RNYTAEEKIFAQRLMRYWANF 514
             + A            HG      +++F  G+P  P+    ++ EEK  + ++M+Y+++F
Sbjct: 2610 MYHAPE-------NYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHF 2662

Query: 515  ARTGDPNEPRD------PKAPQWPPYT--AGAQQYVSLDLRPLEVRRGLRAQACAFWNRF 566
             R+G+PN P +        A  WP +   AG + Y       L  R+GL+   C+FW+++
Sbjct: 2663 IRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEFS-ELLPNRQGLKKADCSFWSKY 2721

Query: 567  LPKLLSATD 575
            +  L ++ D
Sbjct: 2722 ISSLKTSAD 2730


>gi|169216018 PREDICTED: similar to hCG40360 [Homo sapiens]
          Length = 327

 Score =  118 bits (296), Expect = 1e-26
 Identities = 79/216 (36%), Positives = 116/216 (53%), Gaps = 17/216 (7%)

Query: 151 GGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLA 210
           GG F +G++S  ++DG  L   E  ++V + YR+G FGF      + APGN    DQ  A
Sbjct: 20  GGAFETGSAS--IFDGSSLAAYEDMLVVIVQYRLGIFGFFTT-WDQHAPGNWAFKDQVAA 76

Query: 211 LQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATV 270
           L WVQ+N+  FGGDP+SVT+FGES GA SV   +LSP + GLFH+AV++SG     +   
Sbjct: 77  LSWVQKNIEFFGGDPSSVTIFGESVGAISVSSLMLSPMAEGLFHKAVMESGVAIILYLKA 136

Query: 271 GMGEARRRATQLAHLVGCPPGGTGGNDTEL-VACLRTRPAQVLVNHEWHVLPQESVFRFS 329
              E       +A        G   +D+E  + CLRT+ ++ L+      L Q++    +
Sbjct: 137 HDYEKSEDLQVVAQFC-----GYNASDSEAPLRCLRTKSSKELL-----TLSQKTK---A 183

Query: 330 FVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDE 365
           F  VVDG F  + P  L++   F  +  ++GV   E
Sbjct: 184 FTQVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNPE 219


>gi|169215613 PREDICTED: similar to hCG40360 [Homo sapiens]
          Length = 327

 Score =  118 bits (296), Expect = 1e-26
 Identities = 79/216 (36%), Positives = 116/216 (53%), Gaps = 17/216 (7%)

Query: 151 GGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLA 210
           GG F +G++S  ++DG  L   E  ++V + YR+G FGF      + APGN    DQ  A
Sbjct: 20  GGAFETGSAS--IFDGSSLAAYEDMLVVIVQYRLGIFGFFTT-WDQHAPGNWAFKDQVAA 76

Query: 211 LQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATV 270
           L WVQ+N+  FGGDP+SVT+FGES GA SV   +LSP + GLFH+AV++SG     +   
Sbjct: 77  LSWVQKNIEFFGGDPSSVTIFGESVGAISVSSLILSPMAEGLFHKAVMESGVAIILYLKA 136

Query: 271 GMGEARRRATQLAHLVGCPPGGTGGNDTEL-VACLRTRPAQVLVNHEWHVLPQESVFRFS 329
              E       +A        G   +D+E  + CLRT+ ++ L+      L Q++    +
Sbjct: 137 HDYEKSEDLQVVAQFC-----GYNASDSEAPLRCLRTKSSKELL-----TLSQKTK---A 183

Query: 330 FVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDE 365
           F  VVDG F  + P  L++   F  +  ++GV   E
Sbjct: 184 FTQVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNPE 219


>gi|239752162 PREDICTED: similar to hCG40360 [Homo sapiens]
          Length = 131

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 49/110 (44%), Positives = 65/110 (59%), Gaps = 8/110 (7%)

Query: 141 SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPG 200
           SP  VL+W  GG F +G++S  ++DG  L   E  ++V + YR+G FGF      + APG
Sbjct: 16  SPPRVLLWFPGGAFETGSAS--IFDGSSLAAYEDMLVVIVQYRLGIFGFFTT-WDQHAPG 72

Query: 201 NVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSR 250
           N    DQ  AL WVQ+N+  FGGDP+SVT+F     A S G  L+ P SR
Sbjct: 73  NWAFKDQVAALSWVQKNIEFFGGDPSSVTIF----DAVSHGRRLI-PQSR 117


>gi|68299767 arylacetamide deacetylase [Homo sapiens]
          Length = 399

 Score = 40.0 bits (92), Expect = 0.006
 Identities = 37/128 (28%), Positives = 61/128 (47%), Gaps = 17/128 (13%)

Query: 128 LYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYD--GRFLVQAERTVLVSMNYRVG 185
           + + V+ P  +  +    L +I+GGG+  G+++L  YD   R+       V+VS NYR  
Sbjct: 89  ILVRVYVPKRKSEALRRGLFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYR-- 146

Query: 186 AFGFLALPGSREAPGNVGLLDQRLALQWV--QENVAAFGGDPTSVTLFGESAG---AASV 240
                 L      P  +   D   AL+W   ++ +A +G +P  + + G+SAG   AA+V
Sbjct: 147 ------LAPKYHFP--IQFEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAV 198

Query: 241 GMHLLSPP 248
              LL  P
Sbjct: 199 TQQLLDDP 206


>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
          Length = 1682

 Score = 33.5 bits (75), Expect = 0.59
 Identities = 35/121 (28%), Positives = 44/121 (36%), Gaps = 22/121 (18%)

Query: 25  LGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPK 84
           L G  G EG       ++  G R RG   +  G P     G+P   PP+ P    PP P 
Sbjct: 214 LSGPSGEEG-------LSPGGKRRRGCNSEQTGLPP----GLPLPPPPLPPPPPPPPPPP 262

Query: 85  QPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNR------ELSEDCLYLNVWTPYPR 138
            P  G+  +  FQ        TL+      + W P R      E  E    L    PYP 
Sbjct: 263 PPLPGLATSPPFQLTKPGLWSTLH-----GDAWGPERKGSAPPERQEQRHSLPHPYPYPA 317

Query: 139 P 139
           P
Sbjct: 318 P 318


>gi|206597554 arylacetamide deacetylase-like 2 [Homo sapiens]
          Length = 401

 Score = 33.1 bits (74), Expect = 0.77
 Identities = 26/109 (23%), Positives = 51/109 (46%), Gaps = 10/109 (9%)

Query: 130 LNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYD--GRFLVQAERTVLVSMNYRVGAF 187
           + ++ P  +  +    +++ +GGGF  G+S    +D   R+       V+V ++YR    
Sbjct: 91  VRLYLPKRKSETRRRAVIYFHGGGFCFGSSKQRAFDFLNRWTANTLDAVVVGVDYR---- 146

Query: 188 GFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAG 236
             LA      A    GL   +  L  +++ +  +G DPT + + G+S+G
Sbjct: 147 --LAPQHHFPAQFEDGLAAVKFFL--LEKILTKYGVDPTRICIAGDSSG 191


>gi|169166139 PREDICTED: similar to predicted protein [Homo sapiens]
          Length = 1022

 Score = 32.7 bits (73), Expect = 1.0
 Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 8/61 (13%)

Query: 133  WTPYPRPTSPTPVLVWIYGGGFYSGASS-------LDVYDGRFLVQAERTVLVSMNYRVG 185
            W P+PRPT+P PV      GG  +G  +        D   G   VQ E  VL+  +YR+ 
Sbjct: 947  WRPFPRPTAPRPVAPLQRVGGDPAGGGADPQAEGDADAVAGEAAVQ-ESLVLMLKSYRIS 1005

Query: 186  A 186
            +
Sbjct: 1006 S 1006


>gi|169165130 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1002

 Score = 32.7 bits (73), Expect = 1.0
 Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 8/61 (13%)

Query: 133 WTPYPRPTSPTPVLVWIYGGGFYSGASS-------LDVYDGRFLVQAERTVLVSMNYRVG 185
           W P+PRPT+P PV      GG  +G  +        D   G   VQ E  VL+  +YR+ 
Sbjct: 927 WRPFPRPTAPRPVAPLQRVGGDPAGGGADPQAEGDADAVAGEAAVQ-ESLVLMLKSYRIS 985

Query: 186 A 186
           +
Sbjct: 986 S 986


>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
           sapiens]
          Length = 859

 Score = 31.2 bits (69), Expect = 2.9
 Identities = 32/125 (25%), Positives = 52/125 (41%), Gaps = 14/125 (11%)

Query: 248 PSRGLFHRAVLQ-----SGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVA 302
           P + L    VLQ     +G P G   +     +R RA ++   + C  G   G    L  
Sbjct: 38  PEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVR--LQCQSGS--GFLEGLFG 93

Query: 303 CLRTRPAQVLVNHEW---HVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLV 359
           CLR  P   ++   +   H   QE ++   F  ++D  ++    +  +  G FHG +V V
Sbjct: 94  CLR--PVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAV 151

Query: 360 GVVKD 364
             V+D
Sbjct: 152 KKVRD 156


>gi|30179903 SRY (sex determining region Y)-box 8 [Homo sapiens]
          Length = 446

 Score = 30.8 bits (68), Expect = 3.8
 Identities = 20/67 (29%), Positives = 29/67 (43%), Gaps = 16/67 (23%)

Query: 260 SGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELV-----ACLRTRPAQVLVN 314
           S AP  P  + G+G A           G   GG  G+  E       AC+R   +QVL  
Sbjct: 30  SDAPPSPAGSEGLGRA-----------GVAVGGARGDPAEAADERFPACIRDAVSQVLKG 78

Query: 315 HEWHVLP 321
           ++W ++P
Sbjct: 79  YDWSLVP 85


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,942,391
Number of Sequences: 37866
Number of extensions: 1439208
Number of successful extensions: 3845
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3684
Number of HSP's gapped (non-prelim): 50
length of query: 614
length of database: 18,247,518
effective HSP length: 108
effective length of query: 506
effective length of database: 14,157,990
effective search space: 7163942940
effective search space used: 7163942940
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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