BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo sapiens] (614 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo sa... 1276 0.0 gi|7710112 acetylcholinesterase isoform E4-E5 precursor [Homo sa... 1186 0.0 gi|4557351 butyrylcholinesterase precursor [Homo sapiens] 652 0.0 gi|51593088 neuroligin 3 [Homo sapiens] 323 3e-88 gi|31317256 X-linked neuroligin 4 [Homo sapiens] 319 4e-87 gi|24308209 X-linked neuroligin 4 [Homo sapiens] 319 4e-87 gi|7662470 neuroligin 1 [Homo sapiens] 314 1e-85 gi|40538788 neuroligin 4, Y-linked [Homo sapiens] 311 9e-85 gi|30840978 neuroligin 2 [Homo sapiens] 301 1e-81 gi|37622885 carboxylesterase 2 isoform 1 [Homo sapiens] 289 5e-78 gi|219521907 carboxylesterase 7 isoform 1 [Homo sapiens] 284 2e-76 gi|37622887 carboxylesterase 2 isoform 2 [Homo sapiens] 279 6e-75 gi|148536848 carboxyl ester lipase precursor [Homo sapiens] 265 7e-71 gi|33563374 carboxylesterase 3 [Homo sapiens] 264 2e-70 gi|21450749 carboxylesterase 7 isoform 2 [Homo sapiens] 256 3e-68 gi|115529439 carboxylesterase 8 (putative) [Homo sapiens] 251 2e-66 gi|68508967 carboxylesterase 1 isoform a precursor [Homo sapiens] 250 2e-66 gi|68508965 carboxylesterase 1 isoform b precursor [Homo sapiens] 249 4e-66 gi|68508957 carboxylesterase 1 isoform c precursor [Homo sapiens] 247 3e-65 gi|55770862 thyroglobulin [Homo sapiens] 237 3e-62 gi|169216018 PREDICTED: similar to hCG40360 [Homo sapiens] 118 1e-26 gi|169215613 PREDICTED: similar to hCG40360 [Homo sapiens] 118 1e-26 gi|239752162 PREDICTED: similar to hCG40360 [Homo sapiens] 82 1e-15 gi|68299767 arylacetamide deacetylase [Homo sapiens] 40 0.006 gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 33 0.59 gi|206597554 arylacetamide deacetylase-like 2 [Homo sapiens] 33 0.77 gi|169166139 PREDICTED: similar to predicted protein [Homo sapiens] 33 1.0 gi|169165130 PREDICTED: hypothetical protein [Homo sapiens] 33 1.0 gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 31 2.9 gi|30179903 SRY (sex determining region Y)-box 8 [Homo sapiens] 31 3.8 >gi|4557239 acetylcholinesterase isoform E4-E6 precursor [Homo sapiens] Length = 614 Score = 1276 bits (3303), Expect = 0.0 Identities = 614/614 (100%), Positives = 614/614 (100%) Query: 1 MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV 60 MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV Sbjct: 1 MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV 60 Query: 61 SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN 120 SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN Sbjct: 61 SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN 120 Query: 121 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM 180 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM Sbjct: 121 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM 180 Query: 181 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV 240 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV Sbjct: 181 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV 240 Query: 241 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL 300 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL Sbjct: 241 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL 300 Query: 301 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG 360 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG Sbjct: 301 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG 360 Query: 361 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE Sbjct: 361 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420 Query: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY Sbjct: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480 Query: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ Sbjct: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540 Query: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN 600 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN Sbjct: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN 600 Query: 601 QFDHYSKQDRCSDL 614 QFDHYSKQDRCSDL Sbjct: 601 QFDHYSKQDRCSDL 614 >gi|7710112 acetylcholinesterase isoform E4-E5 precursor [Homo sapiens] Length = 617 Score = 1186 bits (3069), Expect = 0.0 Identities = 574/574 (100%), Positives = 574/574 (100%) Query: 1 MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV 60 MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV Sbjct: 1 MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV 60 Query: 61 SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN 120 SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN Sbjct: 61 SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPN 120 Query: 121 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM 180 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM Sbjct: 121 RELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM 180 Query: 181 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV 240 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV Sbjct: 181 NYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV 240 Query: 241 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL 300 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL Sbjct: 241 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL 300 Query: 301 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG 360 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG Sbjct: 301 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG 360 Query: 361 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE Sbjct: 361 VVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420 Query: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY Sbjct: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480 Query: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ Sbjct: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540 Query: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSAT 574 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSAT Sbjct: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSAT 574 >gi|4557351 butyrylcholinesterase precursor [Homo sapiens] Length = 602 Score = 652 bits (1683), Expect = 0.0 Identities = 312/596 (52%), Positives = 417/596 (69%), Gaps = 11/596 (1%) Query: 20 LLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFL 79 LLL +L +G ED ++++ + G++RG+ L GG V+AFLGIP+A+PP+G RF Sbjct: 17 LLLCML---IGKSHTED-DIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFK 72 Query: 80 PPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRP 139 P+ WS + +AT + + C Q +D +PGF G+EMWNPN +LSEDCLYLNVW P P+P Sbjct: 73 KPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKP 132 Query: 140 TSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAP 199 + T VL+WIYGGGF +G SSL VYDG+FL + ER ++VSMNYRVGA GFLALPG+ EAP Sbjct: 133 KNAT-VLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAP 191 Query: 200 GNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQ 259 GN+GL DQ+LALQWVQ+N+AAFGG+P SVTLFGESAGAASV +HLLSP S LF RA+LQ Sbjct: 192 GNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQ 251 Query: 260 SGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHV 319 SG+ N PWA + EAR R LA L GC + N+TE++ CLR + Q ++ +E V Sbjct: 252 SGSFNAPWAVTSLYEARNRTLNLAKLTGC----SRENETEIIKCLRNKDPQEILLNEAFV 307 Query: 320 LPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSK 379 +P + +F P VDGDFL+D P+ L+ G F Q+LVGV KDEG+ FLVYGAPGFSK Sbjct: 308 VPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSK 367 Query: 380 DNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVV 439 DN S+I+R EF G+++ P VS+ E+++ HYTDW+ + P REAL DVVGD+N + Sbjct: 368 DNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFI 427 Query: 440 CPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAE 499 CP + + + G + Y FEHR+S L WP WMGV HGYEIEF+FG+PL+ NYT Sbjct: 428 CPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKA 487 Query: 500 EKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQA 559 E+I ++ +++ WANFA+ G+PNE ++ + WP + + Q+Y++L+ + LRAQ Sbjct: 488 EEILSRSIVKRWANFAKYGNPNETQN-NSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQ 546 Query: 560 CAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHY-SKQDRCSDL 614 C FW F PK+L T +DEAE +WKA FHRW++YM+ WKNQF+ Y SK++ C L Sbjct: 547 CRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL 602 >gi|51593088 neuroligin 3 [Homo sapiens] Length = 828 Score = 323 bits (828), Expect = 3e-88 Identities = 216/630 (34%), Positives = 304/630 (48%), Gaps = 77/630 (12%) Query: 3 PPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPG---GP 59 PP L L L LW L + A + A V G+LRG R+ P GP Sbjct: 7 PPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPT-VNTHFGKLRGARVPLPSEILGP 65 Query: 60 VSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNP 119 V +LG+P+A PP+G +RFLPPEP WSG+ +AT F VC Q + T P + Sbjct: 66 VDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTA 125 Query: 120 N--------RELSEDCLYLNVWTPYP-----------------------RPTSPTPVLVW 148 N +E +EDCLYLNV+ P R + PV+V+ Sbjct: 126 NLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVY 185 Query: 149 IYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQR 208 I+GG + G ++ DG L +++++NYRVG GFL+ G + A GN GLLDQ Sbjct: 186 IHGGSYMEGTGNM--IDGSILASYGNVIVITLNYRVGVLGFLST-GDQAAKGNYGLLDQI 242 Query: 209 LALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWA 268 AL+WV EN+A FGGDP +T+FG GA+ V + LS S GLF RA++QSG+ WA Sbjct: 243 QALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWA 302 Query: 269 TVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRF 328 + + + LA VGC T ++V CLR + A+ LV + Q + + Sbjct: 303 V--NYQPVKYTSLLADKVGCNVLDT----VDMVDCLRQKSAKELVEQD----IQPARYHV 352 Query: 329 SFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRA 388 +F PV+DGD + D PE L+ G+F +++GV + EG F V G D E +S Sbjct: 353 AFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKF-VEGV----VDPEDGVSGT 407 Query: 389 EFLAGVR------VGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPV 442 +F V G P+ D E + YTDW ++P R+ L + DH V P Sbjct: 408 DFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPS 467 Query: 443 AQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPL-DPSR----NYT 497 A A G+ Y Y F H +L P W HG E+ ++FG+P+ P+ N++ Sbjct: 468 VVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFS 527 Query: 498 AEEKIFAQRLMRYWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLD 545 + + + +M YW NFA+TGDPN+ P+D K W Y Q Y+ + Sbjct: 528 KNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIG 587 Query: 546 LRPLEVRRGLRAQACAFWNRFLPKLLSATD 575 L+P VR RA AFW +P L + D Sbjct: 588 LKP-RVRDHYRATKVAFWKHLVPHLYNLHD 616 >gi|31317256 X-linked neuroligin 4 [Homo sapiens] Length = 816 Score = 319 bits (818), Expect = 4e-87 Identities = 208/613 (33%), Positives = 307/613 (50%), Gaps = 59/613 (9%) Query: 1 MRPPQCLLHTPSLASPLLLLL-----LWLLGGGVGAE--GREDAELLVTVRGGRLRGIRL 53 M PQ LL P L +P+ ++L LWL + + +V G++RG+R Sbjct: 1 MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60 Query: 54 KTPG---GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPG 110 P GPV +LG+P+A PP G RRF PPEP W+G+ + T F +VC Q++D Sbjct: 61 PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120 Query: 111 FEGTEMWNPN---------RELSEDCLYLNVWTPYPRP----TSPTPVLVWIYGGGFYSG 157 + +W ++ +EDCLYLN++ P S PV+V+I+GG + G Sbjct: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180 Query: 158 ASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQEN 217 ++ DG L +++++NYR+G GFL+ G + A GN GLLDQ AL+W++EN Sbjct: 181 TGNM--IDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEEN 237 Query: 218 VAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARR 277 V AFGGDP VT+FG AGA+ V + LS S GLF +A++QSG WA + + Sbjct: 238 VGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAV--NYQPAK 295 Query: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337 LA VGC T T++V CLR + + L+ + P + + +F PV+DGD Sbjct: 296 YTRILADKVGCNMLDT----TDMVECLRNKNYKELIQQT--ITP--ATYHIAFGPVIDGD 347 Query: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYF---LVYGAPGFSKDNESLISRAEFLAGV 394 + D P+ L+ G+F +++GV + EG F +V G + N+ S + F+ + Sbjct: 348 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVT-PNDFDFSVSNFVDNL 406 Query: 395 RVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGA 454 G P+ D E + YTDW E+P R+ L + DH V P A A G+ Sbjct: 407 -YGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGS 465 Query: 455 RVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDP-----SRNYTAEEKIFAQRLMR 509 Y Y F H + P W HG E+ ++FGIP+ S N++ + + + +M Sbjct: 466 PTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMT 525 Query: 510 YWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRGLRA 557 YW NFA+TGDPN+ P+D K W Y Q Y+ + L+P VR RA Sbjct: 526 YWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-RVRDHYRA 584 Query: 558 QACAFWNRFLPKL 570 AFW +P L Sbjct: 585 TKVAFWLELVPHL 597 >gi|24308209 X-linked neuroligin 4 [Homo sapiens] Length = 816 Score = 319 bits (818), Expect = 4e-87 Identities = 208/613 (33%), Positives = 307/613 (50%), Gaps = 59/613 (9%) Query: 1 MRPPQCLLHTPSLASPLLLLL-----LWLLGGGVGAE--GREDAELLVTVRGGRLRGIRL 53 M PQ LL P L +P+ ++L LWL + + +V G++RG+R Sbjct: 1 MSRPQGLLWLPLLFTPVCVMLNSNVLLWLTALAIKFTLIDSQAQYPVVNTNYGKIRGLRT 60 Query: 54 KTPG---GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPG 110 P GPV +LG+P+A PP G RRF PPEP W+G+ + T F +VC Q++D Sbjct: 61 PLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLL 120 Query: 111 FEGTEMWNPN---------RELSEDCLYLNVWTPYPRP----TSPTPVLVWIYGGGFYSG 157 + +W ++ +EDCLYLN++ P S PV+V+I+GG + G Sbjct: 121 HDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIHDQNSKKPVMVYIHGGSYMEG 180 Query: 158 ASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQEN 217 ++ DG L +++++NYR+G GFL+ G + A GN GLLDQ AL+W++EN Sbjct: 181 TGNM--IDGSILASYGNVIVITINYRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEEN 237 Query: 218 VAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARR 277 V AFGGDP VT+FG AGA+ V + LS S GLF +A++QSG WA + + Sbjct: 238 VGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAV--NYQPAK 295 Query: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337 LA VGC T T++V CLR + + L+ + P + + +F PV+DGD Sbjct: 296 YTRILADKVGCNMLDT----TDMVECLRNKNYKELIQQT--ITP--ATYHIAFGPVIDGD 347 Query: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYF---LVYGAPGFSKDNESLISRAEFLAGV 394 + D P+ L+ G+F +++GV + EG F +V G + N+ S + F+ + Sbjct: 348 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVT-PNDFDFSVSNFVDNL 406 Query: 395 RVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGA 454 G P+ D E + YTDW E+P R+ L + DH V P A A G+ Sbjct: 407 -YGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGS 465 Query: 455 RVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDP-----SRNYTAEEKIFAQRLMR 509 Y Y F H + P W HG E+ ++FGIP+ S N++ + + + +M Sbjct: 466 PTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMT 525 Query: 510 YWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRGLRA 557 YW NFA+TGDPN+ P+D K W Y Q Y+ + L+P VR RA Sbjct: 526 YWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-RVRDHYRA 584 Query: 558 QACAFWNRFLPKL 570 AFW +P L Sbjct: 585 TKVAFWLELVPHL 597 >gi|7662470 neuroligin 1 [Homo sapiens] Length = 823 Score = 314 bits (805), Expect = 1e-85 Identities = 211/621 (33%), Positives = 306/621 (49%), Gaps = 72/621 (11%) Query: 6 CLLHTPSLASPLLLLLLWLL--GGGVGAEGREDAELLVTVRGGRLRGIRLKTPG---GPV 60 CL+H L +PL L +L L G V ++ +D + LV G++RGI+ + GPV Sbjct: 19 CLVHR-GLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPV 77 Query: 61 SAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQ-YVDTLYPGFEGTEMWNP 119 FLG+P+A PP G RRF PPEP PWS + +AT F VC Q +D P +W Sbjct: 78 IQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVM-LPVWFT 136 Query: 120 N---------RELSEDCLYLNVWTPYPRPT----SPTPVLVWIYGGGFYSGASSLDVYDG 166 N ++ SEDCLYLN++ P P PV+V+I+GG + G +L YDG Sbjct: 137 NNLDVVSSYVQDQSEDCLYLNIYVPTEDDIRDSGGPKPVMVYIHGGSYMEGTGNL--YDG 194 Query: 167 RFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPT 226 L +++++NYR+G GFL+ G + A GN GLLD AL+W EN+ FGGDP Sbjct: 195 SVLASYGNVIVITVNYRLGVLGFLS-TGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPL 253 Query: 227 SVTLFGESAGAASVGMHLLSPPS---------RGLFHRAVLQSGAPNGPWATVGMGEARR 277 +T+FG AG + V + LS S +GLF RA+ QSG WA + + Sbjct: 254 RITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAV--SFQPAK 311 Query: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337 A LA VGC T ELV CL+ +P + LV+ + Q + + +F PV+DGD Sbjct: 312 YARMLATKVGCNVSDT----VELVECLQKKPYKELVDQD----IQPARYHIAFGPVIDGD 363 Query: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVR-- 395 + D P+ L+ G+F +++GV + EG F+ D++ IS ++F V Sbjct: 364 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVEN-----IVDSDDGISASDFDFAVSNF 418 Query: 396 ----VGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAA 451 G P+ D+ E + YTDW +P R+ L + DH V P A + Sbjct: 419 VDNLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSN 478 Query: 452 QGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIP-LDPSR----NYTAEEKIFAQR 506 G+ Y Y F H T P W HG E+ ++ GIP + P+ N++ + + + Sbjct: 479 FGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAV 538 Query: 507 LMRYWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRG 554 +M YW NFA+TGDPN+ P+D K W Y+ Q Y+ + L+P V+ Sbjct: 539 VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKP-RVKEH 597 Query: 555 LRAQACAFWNRFLPKLLSATD 575 RA W +P L + D Sbjct: 598 YRANKVNLWLELVPHLHNLND 618 >gi|40538788 neuroligin 4, Y-linked [Homo sapiens] Length = 816 Score = 311 bits (798), Expect = 9e-85 Identities = 203/613 (33%), Positives = 306/613 (49%), Gaps = 59/613 (9%) Query: 1 MRPPQCLLHTPSLASPLLLLL-----LWLLGGGVGAE--GREDAELLVTVRGGRLRGIRL 53 M PQ LL P L + + ++L LW+ + + +V G+++G+R Sbjct: 1 MLRPQGLLWLPLLFTSVCVMLNSNVLLWITALAIKFTLIDSQAQYPVVNTNYGKIQGLRT 60 Query: 54 KTPG---GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPG 110 P GPV +LG+P+A PP G RRF PPE W+G+ +AT F +VC Q++D + Sbjct: 61 PLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHLDERFLL 120 Query: 111 FEGTEMWNPN---------RELSEDCLYLNVWTPYP----RPTSPTPVLVWIYGGGFYSG 157 + +W ++ +EDCLYLN++ P S PV+V+I+GG + G Sbjct: 121 HDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDDIHEQNSKKPVMVYIHGGSYMEG 180 Query: 158 ASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQEN 217 ++ DG L +++++N R+G GFL+ G + A GN GLLDQ AL+W++EN Sbjct: 181 TGNM--IDGSILASYGNVIVITINCRLGILGFLST-GDQAAKGNYGLLDQIQALRWIEEN 237 Query: 218 VAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARR 277 V AFGGDP VT+FG AGA+ V + LS S GLF +A++QSG WA + + Sbjct: 238 VGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAV--NYQPAK 295 Query: 278 RATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGD 337 LA VGC T T++V CL+ + + L+ + P + + +F PV+DGD Sbjct: 296 YTRILADKVGCNMLDT----TDMVECLKNKNYKELIQQT--ITP--ATYHIAFGPVIDGD 347 Query: 338 FLSDTPEALINAGDFHGLQVLVGVVKDEGSYF---LVYGAPGFSKDNESLISRAEFLAGV 394 + D P+ L+ G+F +++GV + EG F +V G + N+ S + F+ + Sbjct: 348 VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVT-PNDFDFSVSNFVDNL 406 Query: 395 RVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGA 454 G P+ D E + YTDW E+P R+ L + DH V P A A G+ Sbjct: 407 -YGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGS 465 Query: 455 RVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDP-----SRNYTAEEKIFAQRLMR 509 Y Y F H + P W HG E+ ++FGIP+ S N++ + + + +M Sbjct: 466 PTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMT 525 Query: 510 YWANFARTGDPNE--PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRGLRA 557 YW NFA+TGDPN+ P+D K W Y Q Y+ + L+P VR RA Sbjct: 526 YWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIGLKP-RVRDHYRA 584 Query: 558 QACAFWNRFLPKL 570 AFW +P L Sbjct: 585 TKVAFWLELVPHL 597 >gi|30840978 neuroligin 2 [Homo sapiens] Length = 835 Score = 301 bits (771), Expect = 1e-81 Identities = 198/599 (33%), Positives = 292/599 (48%), Gaps = 74/599 (12%) Query: 26 GGGVGAEGREDAELLVTVRGGRLRGIRLKTPG---GPVSAFLGIPFAEPPMGPRRFLPPE 82 G G+G+ G E ++ T G R+RG+R + GPV FLG+P+A PP+G RRF PPE Sbjct: 30 GLGLGSLGEERFPVVNTAYG-RVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPE 88 Query: 83 PKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNREL--------SEDCLYLNVWT 134 W GV +ATT C Q + P + N E SEDCLYLN++ Sbjct: 89 APASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYV 148 Query: 135 PYP--------------------RPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAER 174 P R PV+++++GG + G ++ +DG L Sbjct: 149 PTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNM--FDGSVLAAYGN 206 Query: 175 TVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGES 234 ++ ++NYR+G GFL+ G + A GN GLLDQ AL+W+ EN+A FGGDP +T+FG Sbjct: 207 VIVATLNYRLGVLGFLST-GDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSG 265 Query: 235 AGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTG 294 AGA+ V + +LS S GLF +A+ QSG W+ + + LA VGC Sbjct: 266 AGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSV--NYQPLKYTRLLAAKVGC----DR 319 Query: 295 GNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHG 354 + E V CLR +P++ LV+ + Q + + +F PVVDGD + D PE L+ G+F Sbjct: 320 EDSAEAVECLRRKPSRELVDQD----VQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLN 375 Query: 355 LQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVR------VGVPQVSDLAAEA 408 +L+GV + EG F+ A ++E +S + F V G P+ D+ E Sbjct: 376 YDMLIGVNQGEGLKFVEDSA-----ESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRET 430 Query: 409 VVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTL 468 + YTDW ++ R+ L + DH V P A A + VY Y F H Sbjct: 431 IKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAE 490 Query: 469 SWPLWMGVPHGYEIEFIFGIPLDPSR-----NYTAEEKIFAQRLMRYWANFARTGDPNE- 522 P W HG E+ ++FG+P+ + N++ + + + +M YW NFA+TGDPN+ Sbjct: 491 GRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQP 550 Query: 523 -PRDPK----------APQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKL 570 P+D K W + + +QY+ + L+P VR RA AFW +P L Sbjct: 551 VPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKP-RVRDNYRANKVAFWLELVPHL 608 >gi|37622885 carboxylesterase 2 isoform 1 [Homo sapiens] Length = 623 Score = 289 bits (740), Expect = 5e-78 Identities = 201/582 (34%), Positives = 300/582 (51%), Gaps = 53/582 (9%) Query: 12 SLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFA 69 ++A LLLLL V +G++ A + T G++ G + +K V FLGIPFA Sbjct: 76 AVACGLLLLL-------VRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFA 128 Query: 70 EPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGT-EMWNPNRELSEDCL 128 +PP+GP RF PPEP + WSGV D TT ++C Q + + F M P+ +SEDCL Sbjct: 129 KPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCL 188 Query: 129 YLNVWTP-YPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAF 187 YL+++TP + S PV+VWI+GG G +SL YDG L E V+V + YR+G Sbjct: 189 YLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASL--YDGSMLAALENVVVVIIQYRLGVL 246 Query: 188 GFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSP 247 GF + G + A GN G LDQ AL+WVQ+N+A FGG+P VT+FGESAG SV ++SP Sbjct: 247 GFFST-GDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSP 305 Query: 248 PSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTR 307 S+GLFH A+++SG P + +T +A+L C + LV CLR + Sbjct: 306 ISQGLFHGAIMESGVALLPGLIASSADV--ISTVVANLSACDQ----VDSEALVGCLRGK 359 Query: 308 PAQ--VLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDE 365 + + +N + ++P VVDG FL P+ L+ + DF + +VGV +E Sbjct: 360 SKEEILAINKPFKMIP----------GVVDGVFLPRHPQELLASADFQPVPSIVGVNNNE 409 Query: 366 GSYFL-----VYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420 + + +Y D E+ + + + + + P DL E + Sbjct: 410 FGWLIPKVMRIYDTQK-EMDREASQAALQKMLTLLMLPPTFGDLLREEYI------GDNG 462 Query: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGVPH 478 DP L+ +++ D V P Q+A A VY Y F+H+ S L P M H Sbjct: 463 DPQTLQAQFQEMMADSMFVIPALQVA-HFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADH 521 Query: 479 GYEIEFIFGIPLDPSR-NYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAG 537 G E+ F+F + +T EE+ ++++M+YWANFAR G+PN P WP + Sbjct: 522 GDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKYWANFARNGNPN---GEGLPHWPLFDQ- 577 Query: 538 AQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDE 579 +QY+ L+L+P V R L+A FW + LP+ + + +E Sbjct: 578 EEQYLQLNLQP-AVGRALKAHRLQFWKKALPQKIQELEEPEE 618 >gi|219521907 carboxylesterase 7 isoform 1 [Homo sapiens] Length = 575 Score = 284 bits (726), Expect = 2e-76 Identities = 200/578 (34%), Positives = 298/578 (51%), Gaps = 52/578 (8%) Query: 17 LLLLLLWLLGG---GVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV--SAFLGIPFAEP 71 +L+ +W+L G AEG + R G ++G ++ G PV + FLG+PFA P Sbjct: 11 ILIWAIWVLAAPTKGPSAEGPQR-----NTRLGWIQGKQVTVLGSPVPVNVFLGVPFAAP 65 Query: 72 PMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLN 131 P+G RF P+P PW + +AT++ ++C Q + L ++ P +SEDCLYLN Sbjct: 66 PLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKFGVSEDCLYLN 125 Query: 132 VWTPYPRPT-SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFL 190 ++ P T S PVLVW GG F +G++S ++DG L E ++V + YR+G FGF Sbjct: 126 IYAPAHADTGSKLPVLVWFPGGAFKTGSAS--IFDGSALAAYEDVLVVVVQYRLGIFGFF 183 Query: 191 ALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSR 250 + APGN DQ AL WVQ+N+ FGGDP+SVT+FGESAGA SV +LSP ++ Sbjct: 184 TT-WDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAK 242 Query: 251 GLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTE-LVACLRTRPA 309 GLFH+A+++SG P+ E +AH G +D+E L+ CLRT+P+ Sbjct: 243 GLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFC-----GNNASDSEALLRCLRTKPS 297 Query: 310 QVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYF 369 + L+ L Q++ SF VVDG F + P L++ F + ++GV E + Sbjct: 298 KELL-----TLSQKTK---SFTRVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNHECGFL 349 Query: 370 L-VYGAPG-FSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDP-ARLR 426 L + AP S N+SL + + PQ L A ++ H + +R Sbjct: 350 LPMKEAPEILSGSNKSL--ALHLIQNILHIPPQYLHLVA-------NEYFHDKHSLTEIR 400 Query: 427 EALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTL--SWPLWMGVPHGYEIEF 484 ++L D++GD V P A GA VY Y F HR + P ++ H E+ F Sbjct: 401 DSLLDLLGDVFFVVPALITARYHRDAGAPVYFYEFRHRPQCFEDTKPAFVKADHADEVRF 460 Query: 485 IFG-----IPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQ 539 +FG + T EEK+ ++++M+YWA FARTG+PN WP Y + Sbjct: 461 VFGGAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTGNPN---GNDLSLWPAYNL-TE 516 Query: 540 QYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTL 577 QY+ LDL + + + L+ FW +P +LSA+D L Sbjct: 517 QYLQLDLN-MSLGQRLKEPRVDFWTSTIPLILSASDML 553 >gi|37622887 carboxylesterase 2 isoform 2 [Homo sapiens] Length = 607 Score = 279 bits (713), Expect = 6e-75 Identities = 196/579 (33%), Positives = 296/579 (51%), Gaps = 63/579 (10%) Query: 12 SLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFA 69 ++A LLLLL V +G++ A + T G++ G + +K V FLGIPFA Sbjct: 76 AVACGLLLLL-------VRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFA 128 Query: 70 EPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGT-EMWNPNRELSEDCL 128 +PP+GP RF PPEP + WSGV D TT ++C Q + + F M P+ +SEDCL Sbjct: 129 KPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCL 188 Query: 129 YLNVWTP-YPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAF 187 YL+++TP + S PV+VWI+GG G +SL YDG L E V+V + YR+G Sbjct: 189 YLSIYTPAHSHEGSNLPVMVWIHGGALVFGMASL--YDGSMLAALENVVVVIIQYRLGVL 246 Query: 188 GFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSP 247 GF + G + A GN G LDQ AL+WVQ+N+A FGG+P VT+FGESAG SV ++SP Sbjct: 247 GFFST-GDKHATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSP 305 Query: 248 PSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTR 307 S+GLFH A+++SG P + +T +A+L C + LV CLR + Sbjct: 306 ISQGLFHGAIMESGVALLPGLIASSADV--ISTVVANLSACDQ----VDSEALVGCLRGK 359 Query: 308 PAQ--VLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDE 365 + + +N + ++P VVDG FL P+ L+ + DF + +VGV +E Sbjct: 360 SKEEILAINKPFKMIP----------GVVDGVFLPRHPQELLASADFQPVPSIVGVNNNE 409 Query: 366 GSYFL-----VYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPE 420 + + +Y D E+ + + + + + P DL E + Sbjct: 410 FGWLIPKVMRIYDTQK-EMDREASQAALQKMLTLLMLPPTFGDLLREEYI------GDNG 462 Query: 421 DPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGY 480 DP L+ +++ D V P Q+A A VY Y F+H+ SW + PH Sbjct: 463 DPQTLQAQFQEMMADSMFVIPALQVA-HFQCSRAPVYFYEFQHQP---SWLKNIRPPH-M 517 Query: 481 EIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQ 540 + + + +T EE+ ++++M+YWANFAR G+PN P WP + +Q Sbjct: 518 KADHV---------KFTEEEEQLSRKMMKYWANFARNGNPN---GEGLPHWPLFDQ-EEQ 564 Query: 541 YVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDE 579 Y+ L+L+P V R L+A FW + LP+ + + +E Sbjct: 565 YLQLNLQP-AVGRALKAHRLQFWKKALPQKIQELEEPEE 602 >gi|148536848 carboxyl ester lipase precursor [Homo sapiens] Length = 756 Score = 265 bits (678), Expect = 7e-71 Identities = 181/561 (32%), Positives = 261/561 (46%), Gaps = 58/561 (10%) Query: 41 VTVRGGRLRGIRLKTP--GGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQS 98 V GG + G+ K G V F GIPFA P P+P W G + A F+ Sbjct: 29 VYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKALEN---PQPHPGWQGTLKAKNFKK 85 Query: 99 VCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRP--TSPTPVLVWIYGGGFYS 156 C Q T + EDCLYLN+W P R + PV++WIYGG F Sbjct: 86 RCLQATITQDSTYG-----------DEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLM 134 Query: 157 G----ASSLD--VYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLA 210 G A+ L+ +YDG + ++V+ NYRVG GFL+ G PGN GL DQ +A Sbjct: 135 GSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLST-GDANLPGNYGLRDQHMA 193 Query: 211 LQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATV 270 + WV+ N+AAFGGDP ++TLFGESAG ASV + LSP ++GL RA+ QSG PW V Sbjct: 194 IAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPW--V 251 Query: 271 GMGEARRRATQLAHLVGCPPGGTGGNDTELVACLR-TRPAQVLVNHEWHV--LPQESVFR 327 A ++A VGCP G+ + CL+ T P + + ++ + L + Sbjct: 252 IQKNPLFWAKKVAEKVGCPV----GDAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHY 307 Query: 328 FSFVPVVDGDFLSDTPEAL-INAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNE---- 382 FVPV+DGDF+ P L NA D + + G +G F P +K N+ Sbjct: 308 VGFVPVIDGDFIPADPINLYANAAD---IDYIAGTNNMDGHIFASIDMPAINKGNKKVTE 364 Query: 383 ----SLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNV 438 L+S G+R G D+ E+ W ++ + D D Sbjct: 365 EDFYKLVSEFTITKGLR-GAKTTFDVYTES-------WAQDPSQENKKKTVVDFETDVLF 416 Query: 439 VCP--VAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNY 496 + P +A R A+ A+ YAY+F H + +P W+G H +I+++FG P Y Sbjct: 417 LVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGY 476 Query: 497 TAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSL--DLRPLEVRRG 554 +++ ++ ++ YW NFA+TGDPN W PYT Y+ + + ++R Sbjct: 477 RPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRS 536 Query: 555 LRAQACAFWNRFLPKLLSATD 575 LR +W L + TD Sbjct: 537 LRTNFLRYWTLTYLALPTVTD 557 >gi|33563374 carboxylesterase 3 [Homo sapiens] Length = 571 Score = 264 bits (675), Expect = 2e-70 Identities = 191/560 (34%), Positives = 280/560 (50%), Gaps = 41/560 (7%) Query: 24 LLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGP--VSAFLGIPFAEPPMGPRRFLPP 81 LL A G E A+ V GR+RG ++ G V+ FLGIPFA+PP+GP RF P Sbjct: 19 LLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAP 78 Query: 82 EPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT- 140 P QPW GV DA+T +C Q V+++ +SEDCL LNV++P P Sbjct: 79 HPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAG 138 Query: 141 SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPG 200 S PV+VW++GG +GA++ YDG L V+V++ YR+G GF + G APG Sbjct: 139 SGRPVMVWVHGGALITGAATS--YDGSALAAYGDVVVVTVQYRLGVLGFFST-GDEHAPG 195 Query: 201 NVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQS 260 N G LD AL+WVQEN+A FGGD VT+FG SAG + + +LSP + GLFHRA+ QS Sbjct: 196 NQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQS 255 Query: 261 GAPNGPWATVGMGEAR--RRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWH 318 G P G+ ++ A ++A+ + C + + E+V CL+ + + LV Sbjct: 256 GVITTP----GIIDSHPWPLAQKIANTLAC----SSSSPAEMVQCLQQKEGEELV----- 302 Query: 319 VLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFS 378 + + + VDG +P+ L+ FH + L+GV E S+ + G Sbjct: 303 --LSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRG--WGL 358 Query: 379 KDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLR-EALSDVVGDHN 437 D +SR + LA + V D+ E + ++L A+ + +A + +GD Sbjct: 359 LDTMEQMSREDMLA-ISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVF 417 Query: 438 VVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGVPHGYEIEFIFGIP--LDPS 493 + P + L G+ V+ Y F+HR S+ + P W+ HG E F+FG P +D S Sbjct: 418 INVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDES 477 Query: 494 RNY-----TAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRP 548 T EEK + +M W +FARTGDPN P WP + A+QY+ ++ P Sbjct: 478 SRLAFPEATEEEKQLSLTMMAQWTHFARTGDPN---SKALPPWPQFNQ-AEQYLEINPVP 533 Query: 549 LEVRRGLRAQACAFWNRFLP 568 + R FW+ LP Sbjct: 534 -RAGQKFREAWMQFWSETLP 552 >gi|21450749 carboxylesterase 7 isoform 2 [Homo sapiens] Length = 525 Score = 256 bits (655), Expect = 3e-68 Identities = 189/571 (33%), Positives = 283/571 (49%), Gaps = 88/571 (15%) Query: 17 LLLLLLWLLGG---GVGAEGREDAELLVTVRGGRLRGIRLKTPGGPV--SAFLGIPFAEP 71 +L+ +W+L G AEG + R G ++G ++ G PV + FLG+PFA P Sbjct: 11 ILIWAIWVLAAPTKGPSAEGPQR-----NTRLGWIQGKQVTVLGSPVPVNVFLGVPFAAP 65 Query: 72 PMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLN 131 P+G RF P+P PW + +AT++ ++C Q + L ++ P +SEDCLYLN Sbjct: 66 PLGSLRFTNPQPASPWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKFGVSEDCLYLN 125 Query: 132 VWTPYPRPT-SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFL 190 ++ P T S PVLVW GG F +G++S ++DG L E ++V + YR+G FGF Sbjct: 126 IYAPAHADTGSKLPVLVWFPGGAFKTGSAS--IFDGSALAAYEDVLVVVVQYRLGIFGFF 183 Query: 191 ALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSR 250 + APGN DQ AL WVQ+N+ FGGDP+SVT+FGESAGA SV +LSP ++ Sbjct: 184 TT-WDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAK 242 Query: 251 GLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTE-LVACLRTRPA 309 GLFH+A+++SG P+ E +AH G +D+E L+ CLRT+P+ Sbjct: 243 GLFHKAIMESGVAIIPYLEAHDYEKSEDLQVVAHFC-----GNNASDSEALLRCLRTKPS 297 Query: 310 QVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYF 369 + L+ L Q++ SF VVDG F + P L++ F + ++GV E + Sbjct: 298 KELL-----TLSQKTK---SFTRVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNHECGFL 349 Query: 370 L-VYGAPG-FSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDP-ARLR 426 L + AP S N+SL + + PQ L A ++ H + +R Sbjct: 350 LPMKEAPEILSGSNKSL--ALHLIQNILHIPPQYLHLVA-------NEYFHDKHSLTEIR 400 Query: 427 EALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIF 486 ++L D++GD V P A + R +GA Sbjct: 401 DSLLDLLGDVFFVVP-ALITARYHREGA-------------------------------- 427 Query: 487 GIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDL 546 T EEK+ ++++M+YWA FARTG+PN WP Y +QY+ LDL Sbjct: 428 ----------TEEEKLLSRKMMKYWATFARTGNPN---GNDLSLWPAYNL-TEQYLQLDL 473 Query: 547 RPLEVRRGLRAQACAFWNRFLPKLLSATDTL 577 + + + L+ FW +P +LSA+D L Sbjct: 474 N-MSLGQRLKEPRVDFWTSTIPLILSASDML 503 >gi|115529439 carboxylesterase 8 (putative) [Homo sapiens] Length = 491 Score = 251 bits (640), Expect = 2e-66 Identities = 186/538 (34%), Positives = 255/538 (47%), Gaps = 105/538 (19%) Query: 41 VTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVC 100 V + G L+G ++ P+ FLG+PF+ PP+G RF PPEP +PW G+ DATT+ C Sbjct: 29 VVTKYGTLQGKQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGC 88 Query: 101 YQ----YVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPT-PVLVWIYGGGFY 155 Q + ++Y W SEDCLYLNV+ P P P PV+VW GG F Sbjct: 89 LQESWGQLASMYVSTRERYKW---LRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFI 145 Query: 156 SGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQ 215 GA+S Y+G L E+ VLV + +R+G FGFL+ S A GN GLLDQ AL+WVQ Sbjct: 146 VGAASS--YEGSDLAAREKVVLVFLQHRLGIFGFLSTDDSH-ARGNWGLLDQMAALRWVQ 202 Query: 216 ENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEA 275 EN+AAFGGDP +VTLFG+SAGA S+ ++SP + GLFHRA+ QSG + Sbjct: 203 ENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQSG--TALFRLFITSNP 260 Query: 276 RRRATQLAHLVGCPPGGTGGNDTE-LVACLRTRPAQ--VLVNHEWHVL-------PQESV 325 + A ++AHL GC N T+ LV CLR + V+++ L P+E + Sbjct: 261 LKVAKKVAHLAGC-----NHNSTQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPEEII 315 Query: 326 FRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLI 385 + S PVVDG + D P L+ G + L+GV E ++ L Y +K+ L Sbjct: 316 WSMS--PVVDGVVIPDDPLVLLTQGKVSSVPYLLGVNNLEFNWLLPY---NITKEQVPL- 369 Query: 386 SRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQL 445 VV Y D ++ D LR + D+V D V Q Sbjct: 370 -----------------------VVEEYLDNVNEHDWKMLRNRMMDIVQDATFVYATLQT 406 Query: 446 AGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQ 505 A HR ++ +EK + Sbjct: 407 A--------------HYHRGLSM-----------------------------GKEKALSL 423 Query: 506 RLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFW 563 ++M+YWANFARTG+PN D P WP Y ++Y+ LD V L+ + AFW Sbjct: 424 QMMKYWANFARTGNPN---DGNLPCWPRYNKD-EKYLQLDF-TTRVGMKLKEKKMAFW 476 >gi|68508967 carboxylesterase 1 isoform a precursor [Homo sapiens] Length = 568 Score = 250 bits (639), Expect = 2e-66 Identities = 188/574 (32%), Positives = 288/574 (50%), Gaps = 43/574 (7%) Query: 17 LLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFAEPPMG 74 L +L L G + +V G++ G + L+ PV+ FLGIPFA+PP+G Sbjct: 3 LRAFILATLSASAAWAGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLG 62 Query: 75 PRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRE-----LSEDCLY 129 P RF PP+P +PWS V +AT++ +C Q G +E++ +E LSEDCLY Sbjct: 63 PLRFTPPQPAEPWSFVKNATSYPPMCTQDPKA---GQLLSELFTNRKENIPLKLSEDCLY 119 Query: 130 LNVWTPYP-RPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFG 188 LN++TP + PV+VWI+GGG GA+S YDG L E V+V++ YR+G +G Sbjct: 120 LNIYTPADLTKKNRLPVMVWIHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIWG 177 Query: 189 FLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPP 248 F + G + GN G LDQ AL+WVQ+N+A+FGG+P SVT+FGESAG SV + +LSP Sbjct: 178 FFST-GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPL 236 Query: 249 SRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRP 308 ++ LFHRA+ +SG V G+ + A Q+A GC +V CLR + Sbjct: 237 AKNLFHRAISESGVALTS-VLVKKGDVKPLAEQIAITAGCKT----TTSAVMVHCLRQKT 291 Query: 309 AQVLVNHEWHVL---------PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLV 359 + L+ + P+ES + V+DG L TPE L +FH + +V Sbjct: 292 EEELLETTLKMKFLSLDLQGDPRES--QPLLGTVIDGMLLLKTPEELQAERNFHTVPYMV 349 Query: 360 GVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWL-H 418 G+ K E + + + +E + + ++ + P V +A E + +L Sbjct: 350 GINKQEFGWLIPMQLMSYPL-SEGQLDQKTAMSLLWKSYPLVC-IAKELIPEATEKYLGG 407 Query: 419 PEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGV 476 +D + ++ D++ D P +A GA Y Y F++R S S P + Sbjct: 408 TDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIG 467 Query: 477 PHGYEIEFIFGIPLDPSRNYTAEEKI-FAQRLMRYWANFARTGDPNEPRDPKAPQWPPYT 535 HG E+ +FG P + +EE+I ++ +M++WANFAR G+PN P WP Y Sbjct: 468 DHGDELFSVFGAPF--LKEGASEEEIRLSKMVMKFWANFARNGNPN---GEGLPHWPEYN 522 Query: 536 AGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPK 569 + Y+ + + + L+ + AFW K Sbjct: 523 Q-KEGYLQIGAN-TQAAQKLKDKEVAFWTNLFAK 554 >gi|68508965 carboxylesterase 1 isoform b precursor [Homo sapiens] Length = 567 Score = 249 bits (637), Expect = 4e-66 Identities = 186/560 (33%), Positives = 285/560 (50%), Gaps = 43/560 (7%) Query: 31 AEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWS 88 A G + +V G++ G + L+ PV+ FLGIPFA+PP+GP RF PP+P +PWS Sbjct: 16 AWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWS 75 Query: 89 GVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRE-----LSEDCLYLNVWTPYP-RPTSP 142 V +AT++ +C Q G +E++ +E LSEDCLYLN++TP + Sbjct: 76 FVKNATSYPPMCTQDPKA---GQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNR 132 Query: 143 TPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNV 202 PV+VWI+GGG GA+S YDG L E V+V++ YR+G +GF + G + GN Sbjct: 133 LPVMVWIHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIWGFFST-GDEHSRGNW 189 Query: 203 GLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGA 262 G LDQ AL+WVQ+N+A+FGG+P SVT+FGESAG SV + +LSP ++ LFHRA+ +SG Sbjct: 190 GHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGV 249 Query: 263 PNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVL-- 320 V G+ + A Q+A GC +V CLR + + L+ + Sbjct: 250 ALTS-VLVKKGDVKPLAEQIAITAGCKT----TTSAVMVHCLRQKTEEELLETTLKMKFL 304 Query: 321 -------PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYG 373 P+ES + V+DG L TPE L +FH + +VG+ K E + + Sbjct: 305 SLDLQGDPRES--QPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQ 362 Query: 374 APGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWL-HPEDPARLREALSDV 432 + +E + + ++ + P V +A E + +L +D + ++ D+ Sbjct: 363 LMSYPL-SEGQLDQKTAMSLLWKSYPLVC-IAKELIPEATEKYLGGTDDTVKKKDLFLDL 420 Query: 433 VGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGVPHGYEIEFIFGIPL 490 + D P +A GA Y Y F++R S S P + HG E+ +FG P Sbjct: 421 IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF 480 Query: 491 DPSRNYTAEEKI-FAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPL 549 + +EE+I ++ +M++WANFAR G+PN P WP Y + Y+ + Sbjct: 481 --LKEGASEEEIRLSKMVMKFWANFARNGNPN---GEGLPHWPEYNQ-KEGYLQIGAN-T 533 Query: 550 EVRRGLRAQACAFWNRFLPK 569 + + L+ + AFW K Sbjct: 534 QAAQKLKDKEVAFWTNLFAK 553 >gi|68508957 carboxylesterase 1 isoform c precursor [Homo sapiens] Length = 566 Score = 247 bits (630), Expect = 3e-65 Identities = 187/562 (33%), Positives = 286/562 (50%), Gaps = 48/562 (8%) Query: 31 AEGREDAELLVTVRGGRLRG--IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWS 88 A G + +V G++ G + L+ PV+ FLGIPFA+PP+GP RF PP+P +PWS Sbjct: 16 AWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWS 75 Query: 89 GVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRE-----LSEDCLYLNVWTPYP-RPTSP 142 V +AT++ +C Q G +E++ +E LSEDCLYLN++TP + Sbjct: 76 FVKNATSYPPMCTQDPKA---GQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNR 132 Query: 143 TPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNV 202 PV+VWI+GGG GA+S YDG L E V+V++ YR+G +GF + G + GN Sbjct: 133 LPVMVWIHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYRLGIWGFFST-GDEHSRGNW 189 Query: 203 GLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGA 262 G LDQ AL+WVQ+N+A+FGG+P SVT+FGESAG SV + +LSP ++ LFHRA+ +SG Sbjct: 190 GHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGV 249 Query: 263 PNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVL-- 320 V G+ + A Q+A GC +V CLR + + L+ + Sbjct: 250 ALTS-VLVKKGDVKPLAEQIAITAGCKT----TTSAVMVHCLRQKTEEELLETTLKMKFL 304 Query: 321 -------PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYF--LV 371 P+ES + V+DG L TPE L +FH + +VG+ K E + ++ Sbjct: 305 SLDLQGDPRES--QPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPML 362 Query: 372 YGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWL-HPEDPARLREALS 430 P +E + + ++ + P V +A E + +L +D + ++ Sbjct: 363 MSYP----LSEGQLDQKTAMSLLWKSYPLVC-IAKELIPEATEKYLGGTDDTVKKKDLFL 417 Query: 431 DVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLS--WPLWMGVPHGYEIEFIFGI 488 D++ D P +A GA Y Y F++R S S P + HG E+ +FG Sbjct: 418 DLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGA 477 Query: 489 PLDPSRNYTAEEKI-FAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLR 547 P + +EE+I ++ +M++WANFAR G+PN P WP Y + Y+ + Sbjct: 478 PF--LKEGASEEEIRLSKMVMKFWANFARNGNPN---GEGLPHWPEYNQ-KEGYLQIGAN 531 Query: 548 PLEVRRGLRAQACAFWNRFLPK 569 + + L+ + AFW K Sbjct: 532 -TQAAQKLKDKEVAFWTNLFAK 552 >gi|55770862 thyroglobulin [Homo sapiens] Length = 2768 Score = 237 bits (604), Expect = 3e-62 Identities = 171/549 (31%), Positives = 269/549 (48%), Gaps = 48/549 (8%) Query: 46 GRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVD 105 GR + I++ T V FLG+P+A PP+ RRF PEP W+G DA+ ++ C+Q Sbjct: 2211 GRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASCWQ--- 2266 Query: 106 TLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYD 165 GT + + +SEDCLYLNV+ P + + VLV+ + + D Sbjct: 2267 ------PGTRT-STSPGVSEDCLYLNVFIPQNVAPNAS-VLVFFHNTMDREESEGWPAID 2318 Query: 166 GRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDP 225 G FL ++V+ +YRVG FGFL+ GS E GN GLLDQ AL WVQ ++ FGGDP Sbjct: 2319 GSFLAAVGNLIVVTASYRVGVFGFLS-SGSGEVSGNWGLLDQVAALTWVQTHIRGFGGDP 2377 Query: 226 TSVTLFGESAGAASVGMHLLSPPSRG--LFHRAVLQSGAPNGPWATVGMGEARRRATQLA 283 V+L + GA +HLL+ + LF RAVL G+ P A + A+++A LA Sbjct: 2378 RRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALA 2437 Query: 284 HLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTP 343 V CP + E+V+CLR +PA VL + + +L F + + PV+DG FL + P Sbjct: 2438 KEVSCPM----SSSQEVVSCLRQKPANVLNDAQTKLLAVSGPFHY-WGPVIDGHFLREPP 2492 Query: 344 EALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGV-PQVS 402 + + + +L+G +D+G F + S+ F ++ + + S Sbjct: 2493 ARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQNSLGGEDS 2552 Query: 403 DLAAEAVVLHYTDWLH-PEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVF 461 D EA Y H +D A AL + D+ ++CP+ +A +A R VF Sbjct: 2553 DARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMA---SAWAKRARGNVF 2609 Query: 462 EHRASTLSWPLWMGVPHG-----YEIEFIFGIPLDPS--RNYTAEEKIFAQRLMRYWANF 514 + A HG +++F G+P P+ ++ EEK + ++M+Y+++F Sbjct: 2610 MYHAPE-------NYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSLSLKIMQYFSHF 2662 Query: 515 ARTGDPNEPRD------PKAPQWPPYT--AGAQQYVSLDLRPLEVRRGLRAQACAFWNRF 566 R+G+PN P + A WP + AG + Y L R+GL+ C+FW+++ Sbjct: 2663 IRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYKEFS-ELLPNRQGLKKADCSFWSKY 2721 Query: 567 LPKLLSATD 575 + L ++ D Sbjct: 2722 ISSLKTSAD 2730 >gi|169216018 PREDICTED: similar to hCG40360 [Homo sapiens] Length = 327 Score = 118 bits (296), Expect = 1e-26 Identities = 79/216 (36%), Positives = 116/216 (53%), Gaps = 17/216 (7%) Query: 151 GGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLA 210 GG F +G++S ++DG L E ++V + YR+G FGF + APGN DQ A Sbjct: 20 GGAFETGSAS--IFDGSSLAAYEDMLVVIVQYRLGIFGFFTT-WDQHAPGNWAFKDQVAA 76 Query: 211 LQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATV 270 L WVQ+N+ FGGDP+SVT+FGES GA SV +LSP + GLFH+AV++SG + Sbjct: 77 LSWVQKNIEFFGGDPSSVTIFGESVGAISVSSLMLSPMAEGLFHKAVMESGVAIILYLKA 136 Query: 271 GMGEARRRATQLAHLVGCPPGGTGGNDTEL-VACLRTRPAQVLVNHEWHVLPQESVFRFS 329 E +A G +D+E + CLRT+ ++ L+ L Q++ + Sbjct: 137 HDYEKSEDLQVVAQFC-----GYNASDSEAPLRCLRTKSSKELL-----TLSQKTK---A 183 Query: 330 FVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDE 365 F VVDG F + P L++ F + ++GV E Sbjct: 184 FTQVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNPE 219 >gi|169215613 PREDICTED: similar to hCG40360 [Homo sapiens] Length = 327 Score = 118 bits (296), Expect = 1e-26 Identities = 79/216 (36%), Positives = 116/216 (53%), Gaps = 17/216 (7%) Query: 151 GGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLA 210 GG F +G++S ++DG L E ++V + YR+G FGF + APGN DQ A Sbjct: 20 GGAFETGSAS--IFDGSSLAAYEDMLVVIVQYRLGIFGFFTT-WDQHAPGNWAFKDQVAA 76 Query: 211 LQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATV 270 L WVQ+N+ FGGDP+SVT+FGES GA SV +LSP + GLFH+AV++SG + Sbjct: 77 LSWVQKNIEFFGGDPSSVTIFGESVGAISVSSLILSPMAEGLFHKAVMESGVAIILYLKA 136 Query: 271 GMGEARRRATQLAHLVGCPPGGTGGNDTEL-VACLRTRPAQVLVNHEWHVLPQESVFRFS 329 E +A G +D+E + CLRT+ ++ L+ L Q++ + Sbjct: 137 HDYEKSEDLQVVAQFC-----GYNASDSEAPLRCLRTKSSKELL-----TLSQKTK---A 183 Query: 330 FVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDE 365 F VVDG F + P L++ F + ++GV E Sbjct: 184 FTQVVDGAFFPNEPLDLLSQKAFKAIPSIIGVNNPE 219 >gi|239752162 PREDICTED: similar to hCG40360 [Homo sapiens] Length = 131 Score = 82.4 bits (202), Expect = 1e-15 Identities = 49/110 (44%), Positives = 65/110 (59%), Gaps = 8/110 (7%) Query: 141 SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPG 200 SP VL+W GG F +G++S ++DG L E ++V + YR+G FGF + APG Sbjct: 16 SPPRVLLWFPGGAFETGSAS--IFDGSSLAAYEDMLVVIVQYRLGIFGFFTT-WDQHAPG 72 Query: 201 NVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSR 250 N DQ AL WVQ+N+ FGGDP+SVT+F A S G L+ P SR Sbjct: 73 NWAFKDQVAALSWVQKNIEFFGGDPSSVTIF----DAVSHGRRLI-PQSR 117 >gi|68299767 arylacetamide deacetylase [Homo sapiens] Length = 399 Score = 40.0 bits (92), Expect = 0.006 Identities = 37/128 (28%), Positives = 61/128 (47%), Gaps = 17/128 (13%) Query: 128 LYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYD--GRFLVQAERTVLVSMNYRVG 185 + + V+ P + + L +I+GGG+ G+++L YD R+ V+VS NYR Sbjct: 89 ILVRVYVPKRKSEALRRGLFYIHGGGWCVGSAALSGYDLLSRWTADRLDAVVVSTNYR-- 146 Query: 186 AFGFLALPGSREAPGNVGLLDQRLALQWV--QENVAAFGGDPTSVTLFGESAG---AASV 240 L P + D AL+W ++ +A +G +P + + G+SAG AA+V Sbjct: 147 ------LAPKYHFP--IQFEDVYNALRWFLRKKVLAKYGVNPERIGISGDSAGGNLAAAV 198 Query: 241 GMHLLSPP 248 LL P Sbjct: 199 TQQLLDDP 206 >gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] Length = 1682 Score = 33.5 bits (75), Expect = 0.59 Identities = 35/121 (28%), Positives = 44/121 (36%), Gaps = 22/121 (18%) Query: 25 LGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPK 84 L G G EG ++ G R RG + G P G+P PP+ P PP P Sbjct: 214 LSGPSGEEG-------LSPGGKRRRGCNSEQTGLPP----GLPLPPPPLPPPPPPPPPPP 262 Query: 85 QPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNR------ELSEDCLYLNVWTPYPR 138 P G+ + FQ TL+ + W P R E E L PYP Sbjct: 263 PPLPGLATSPPFQLTKPGLWSTLH-----GDAWGPERKGSAPPERQEQRHSLPHPYPYPA 317 Query: 139 P 139 P Sbjct: 318 P 318 >gi|206597554 arylacetamide deacetylase-like 2 [Homo sapiens] Length = 401 Score = 33.1 bits (74), Expect = 0.77 Identities = 26/109 (23%), Positives = 51/109 (46%), Gaps = 10/109 (9%) Query: 130 LNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYD--GRFLVQAERTVLVSMNYRVGAF 187 + ++ P + + +++ +GGGF G+S +D R+ V+V ++YR Sbjct: 91 VRLYLPKRKSETRRRAVIYFHGGGFCFGSSKQRAFDFLNRWTANTLDAVVVGVDYR---- 146 Query: 188 GFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAG 236 LA A GL + L +++ + +G DPT + + G+S+G Sbjct: 147 --LAPQHHFPAQFEDGLAAVKFFL--LEKILTKYGVDPTRICIAGDSSG 191 >gi|169166139 PREDICTED: similar to predicted protein [Homo sapiens] Length = 1022 Score = 32.7 bits (73), Expect = 1.0 Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 8/61 (13%) Query: 133 WTPYPRPTSPTPVLVWIYGGGFYSGASS-------LDVYDGRFLVQAERTVLVSMNYRVG 185 W P+PRPT+P PV GG +G + D G VQ E VL+ +YR+ Sbjct: 947 WRPFPRPTAPRPVAPLQRVGGDPAGGGADPQAEGDADAVAGEAAVQ-ESLVLMLKSYRIS 1005 Query: 186 A 186 + Sbjct: 1006 S 1006 >gi|169165130 PREDICTED: hypothetical protein [Homo sapiens] Length = 1002 Score = 32.7 bits (73), Expect = 1.0 Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 8/61 (13%) Query: 133 WTPYPRPTSPTPVLVWIYGGGFYSGASS-------LDVYDGRFLVQAERTVLVSMNYRVG 185 W P+PRPT+P PV GG +G + D G VQ E VL+ +YR+ Sbjct: 927 WRPFPRPTAPRPVAPLQRVGGDPAGGGADPQAEGDADAVAGEAAVQ-ESLVLMLKSYRIS 985 Query: 186 A 186 + Sbjct: 986 S 986 >gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo sapiens] Length = 859 Score = 31.2 bits (69), Expect = 2.9 Identities = 32/125 (25%), Positives = 52/125 (41%), Gaps = 14/125 (11%) Query: 248 PSRGLFHRAVLQ-----SGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVA 302 P + L VLQ +G P G + +R RA ++ + C G G L Sbjct: 38 PEKDLTPTHVLQLHEQDAGGPGGAAGSPESRASRVRADEVR--LQCQSGS--GFLEGLFG 93 Query: 303 CLRTRPAQVLVNHEW---HVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLV 359 CLR P ++ + H QE ++ F ++D ++ + + G FHG +V V Sbjct: 94 CLR--PVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAV 151 Query: 360 GVVKD 364 V+D Sbjct: 152 KKVRD 156 >gi|30179903 SRY (sex determining region Y)-box 8 [Homo sapiens] Length = 446 Score = 30.8 bits (68), Expect = 3.8 Identities = 20/67 (29%), Positives = 29/67 (43%), Gaps = 16/67 (23%) Query: 260 SGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELV-----ACLRTRPAQVLVN 314 S AP P + G+G A G GG G+ E AC+R +QVL Sbjct: 30 SDAPPSPAGSEGLGRA-----------GVAVGGARGDPAEAADERFPACIRDAVSQVLKG 78 Query: 315 HEWHVLP 321 ++W ++P Sbjct: 79 YDWSLVP 85 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.139 0.447 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 27,942,391 Number of Sequences: 37866 Number of extensions: 1439208 Number of successful extensions: 3845 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 25 Number of HSP's successfully gapped in prelim test: 14 Number of HSP's that attempted gapping in prelim test: 3684 Number of HSP's gapped (non-prelim): 50 length of query: 614 length of database: 18,247,518 effective HSP length: 108 effective length of query: 506 effective length of database: 14,157,990 effective search space: 7163942940 effective search space used: 7163942940 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.