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Search of human proteins with 45439342
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45439342 peptidylprolyl isomerase (cyclophilin)-like 5
isoform 1 [Homo sapiens]
(414 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45439342 peptidylprolyl isomerase (cyclophilin)-like 5 isofor... 828 0.0
gi|45439346 peptidylprolyl isomerase (cyclophilin)-like 5 isofor... 189 4e-48
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 92 1e-18
gi|238908508 leucine-rich repeat and death domain-containing pro... 84 3e-16
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 83 4e-16
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 78 2e-14
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 77 4e-14
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 77 4e-14
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 75 1e-13
gi|45827729 scribble isoform b [Homo sapiens] 74 2e-13
gi|45827731 scribble isoform a [Homo sapiens] 74 2e-13
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 74 3e-13
gi|62241040 leucine rich repeat containing 8 family, member A [H... 72 7e-13
gi|187829877 leucine rich repeat containing 8 family, member A [... 72 7e-13
gi|187829871 leucine rich repeat containing 8 family, member A [... 72 7e-13
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 72 9e-13
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 71 2e-12
gi|63003903 leucine rich repeat containing 10 [Homo sapiens] 70 5e-12
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 70 5e-12
gi|197333706 leucine rich repeat containing 8 family, member D [... 69 6e-12
gi|34222199 leucine rich repeat containing 8 family, member D [H... 69 6e-12
gi|61742786 leucine rich repeat and death domain containing prot... 69 6e-12
gi|61742784 leucine rich repeat and death domain containing prot... 69 6e-12
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 69 6e-12
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 68 1e-11
gi|33285015 leucine rich repeat containing 28 [Homo sapiens] 68 1e-11
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 67 2e-11
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 67 2e-11
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 67 2e-11
gi|197333692 leucine rich repeat containing 8 family, member B [... 67 3e-11
>gi|45439342 peptidylprolyl isomerase (cyclophilin)-like 5 isoform 1
[Homo sapiens]
Length = 414
Score = 828 bits (2139), Expect = 0.0
Identities = 414/414 (100%), Positives = 414/414 (100%)
Query: 1 MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY 60
MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY
Sbjct: 1 MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY 60
Query: 61 ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGCNVDTPV 120
ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGCNVDTPV
Sbjct: 61 ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGCNVDTPV 120
Query: 121 STLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLR 180
STLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLR
Sbjct: 121 STLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLR 180
Query: 181 KLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKA 240
KLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKA
Sbjct: 181 KLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKA 240
Query: 241 LPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLD 300
LPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLD
Sbjct: 241 LPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLD 300
Query: 301 LFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCG 360
LFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCG
Sbjct: 301 LFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCG 360
Query: 361 RFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK 414
RFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK
Sbjct: 361 RFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK 414
>gi|45439346 peptidylprolyl isomerase (cyclophilin)-like 5 isoform
3 [Homo sapiens]
Length = 146
Score = 189 bits (480), Expect = 4e-48
Identities = 94/94 (100%), Positives = 94/94 (100%)
Query: 1 MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY 60
MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY
Sbjct: 1 MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY 60
Query: 61 ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSK 94
ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSK
Sbjct: 61 ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSK 94
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 91.7 bits (226), Expect = 1e-18
Identities = 82/238 (34%), Positives = 117/238 (49%), Gaps = 26/238 (10%)
Query: 174 LCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDL 233
LC +SL+ L+LS N +++PA++ +L LQ L+L N L+S + LQ SL L L
Sbjct: 118 LC-RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEI--ENLQ-SLECLYL 173
Query: 234 SKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRN 293
N IK +P + L L L L DN++ P ++ QL +LR LS N L +LP E N
Sbjct: 174 GGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILN 233
Query: 294 L-SLEYLDLFGNTFEQPKVLPVIK--LQAPLTLLESSARTILHNRIPYGSHIIPFHLCQD 350
L LE L L GN P V+ ++ P TLLE +ARTI I Y + +P +L +
Sbjct: 234 LIHLEELSLRGN----PLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRY 289
Query: 351 LDTAKIC---VCGRFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGC 405
L +A C CG + ++ + VD G P++ Y CS C
Sbjct: 290 LGSASNCPNPKCGGVYFDCCVR------------QIKFVDFCGKYRLPLMHYLCSPEC 335
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 83.6 bits (205), Expect = 3e-16
Identities = 57/168 (33%), Positives = 92/168 (54%), Gaps = 7/168 (4%)
Query: 145 DYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQE 204
+ P+ +F L HL+ S L+ L +L+ LDL N IKK+PA+I ++I L
Sbjct: 501 EIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHV 560
Query: 205 LNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQF 264
L L N E+F LC TL+ +L+ LDLS+N+++ + C L+ ++ L N+ I F
Sbjct: 561 LILCCNKFETFPRELC--TLE-NLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHF 617
Query: 265 PCKIGQLINLRFLSAAR---NKLPFLPSEFRNLS-LEYLDLFGNTFEQ 308
P ++ QL +L L+ ++ KL LP E N++ L+ LD+ N +
Sbjct: 618 PIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIRE 665
Score = 77.0 bits (188), Expect = 3e-14
Identities = 52/163 (31%), Positives = 84/163 (51%), Gaps = 3/163 (1%)
Query: 144 KDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLC-LKSLRKLDLSHNHIKKLPATIGDLIHL 202
K P S + SL H+ C R LC L++L+ LDLS N ++K+ + I +L +
Sbjct: 546 KKIPASISNMISL-HVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGI 604
Query: 203 QELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELI 262
Q+LN + N F + LC + L + K+ LP + + +LK L + +N +
Sbjct: 605 QKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIR 664
Query: 263 QFPCKIGQLINLRFLSAARNKLPFLPSEFRNLS-LEYLDLFGN 304
+ P IG+L NL L A N++ +LP +L+ L+ L+L GN
Sbjct: 665 EIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGN 707
Score = 70.5 bits (171), Expect = 3e-12
Identities = 54/181 (29%), Positives = 90/181 (49%), Gaps = 7/181 (3%)
Query: 156 LEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESF 215
LE L GL + + L +LR L++SHNHI +P I L ++++L +N++E+F
Sbjct: 190 LEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENF 249
Query: 216 SVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFP---CKIGQLI 272
L +L L L KNK++ +P L+ L+ L L+ N+L FP C + +LI
Sbjct: 250 PSDL---ECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306
Query: 273 NLRFLSAARNKLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTIL 332
+L + LP E +NL +D TF ++ ++K++ L L ++ I
Sbjct: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIK-ELQLADNKLEVIS 365
Query: 333 H 333
H
Sbjct: 366 H 366
Score = 69.3 bits (168), Expect = 6e-12
Identities = 47/129 (36%), Positives = 68/129 (52%), Gaps = 6/129 (4%)
Query: 175 CLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLS 234
CL +L L L N ++ +P T+ L L+ LNL N L +F ALC L SLDL+
Sbjct: 255 CLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALC---FLPKLISLDLT 311
Query: 235 KNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLP---SEF 291
N I +LP + +L+ L+ L +D N+L +I QL+ ++ L A NKL + F
Sbjct: 312 GNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENF 371
Query: 292 RNLSLEYLD 300
R L + LD
Sbjct: 372 RELRILILD 380
Score = 60.1 bits (144), Expect = 4e-09
Identities = 49/179 (27%), Positives = 89/179 (49%), Gaps = 5/179 (2%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
+L L + +V++ + L ++ L+ S N I +P I + + ++ L+ N +
Sbjct: 419 NLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMY 478
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
F + LC SL L ++ N I +PV ++L +L+L +N+L+ F LINL
Sbjct: 479 FPLGLC---ALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINL 535
Query: 275 RFLSAARNKLPFLPSEFRN-LSLEYLDLFGNTFEQ-PKVLPVIKLQAPLTLLESSARTI 331
++L +N++ +P+ N +SL L L N FE P+ L ++ L L E+ + I
Sbjct: 536 KYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKI 594
Score = 59.7 bits (143), Expect = 5e-09
Identities = 53/155 (34%), Positives = 75/155 (48%), Gaps = 14/155 (9%)
Query: 165 GLVRVDMRMLCLKSLRKLDLSHNHIKKLP-ATIGDLIHLQELNLNDNHLESFSVALCHST 223
GL +L +K ++ L L N IK A GDL+ L+ L+L +N L S +
Sbjct: 152 GLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEI---Q 208
Query: 224 LQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNK 283
L +LR L++S N I +P + QL ++ L +N + FP + L NL LS +NK
Sbjct: 209 LLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNK 268
Query: 284 LPFLP------SEFRNLSLEYLDLFGNTFEQPKVL 312
L +P R L+LEY L TF PK L
Sbjct: 269 LRHIPDTLPSLKTLRVLNLEYNQL--TTF--PKAL 299
Score = 57.4 bits (137), Expect = 2e-08
Identities = 40/109 (36%), Positives = 57/109 (52%), Gaps = 3/109 (2%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
LK+L L + HN + L I L+ ++EL L DN LE S + + + LR L L K
Sbjct: 325 LKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENF---RELRILILDK 381
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKL 284
N +K +P + L+ L L DN+L + P I +L NLR L RN +
Sbjct: 382 NLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNM 430
Score = 56.6 bits (135), Expect = 4e-08
Identities = 43/133 (32%), Positives = 68/133 (51%), Gaps = 10/133 (7%)
Query: 155 SLEHLQTSYCG---LVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNH 211
SLE L S L R+ + + L++LD+S+N I+++P IG+L +L L+ +N
Sbjct: 626 SLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQ 685
Query: 212 LESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFP---CKI 268
+ +L L+ L+LS N + ALP + LK + DDN L++ P CK
Sbjct: 686 ISYLPPSLLSLN---DLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKG 742
Query: 269 GQLINL-RFLSAA 280
QL + R+L A
Sbjct: 743 KQLYTIARYLQRA 755
Score = 53.5 bits (127), Expect = 3e-07
Identities = 43/141 (30%), Positives = 64/141 (45%), Gaps = 3/141 (2%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
+L L Y L + L L LDL+ N I LP I +L +L+ L ++ N L
Sbjct: 281 TLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTF 340
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
+V + ++ L L+ NK++ + + +EL+ L LD N L P KI L
Sbjct: 341 LAVEIFQLL---KIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAML 397
Query: 275 RFLSAARNKLPFLPSEFRNLS 295
LS + NKL LP L+
Sbjct: 398 ECLSLSDNKLTELPKYIHKLN 418
Score = 38.9 bits (89), Expect = 0.009
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 4/70 (5%)
Query: 173 MLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHS----TLQKSL 228
+L L L++L+LS N++ LP+ I ++ L+E+N +DN L V +C T+ + L
Sbjct: 693 LLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYL 752
Query: 229 RSLDLSKNKI 238
+ D KI
Sbjct: 753 QRADERDEKI 762
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 83.2 bits (204), Expect = 4e-16
Identities = 59/170 (34%), Positives = 86/170 (50%), Gaps = 9/170 (5%)
Query: 151 NFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDN 210
NF +LE L + + ++ ++LRKL + N + LP TI L++L+EL+++ N
Sbjct: 43 NFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKN 102
Query: 211 HLESF--SVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKI 268
++ F ++ C K L ++ S N I LP F QL L L L+D L P
Sbjct: 103 GVQEFPENIKCC-----KCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANF 157
Query: 269 GQLINLRFLSAARNKLPFLPSEFRNLS-LEYLDLFGNTF-EQPKVLPVIK 316
G+L+ LR L N L LP L+ LE LDL N F E P+VL I+
Sbjct: 158 GRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQ 207
Score = 70.5 bits (171), Expect = 3e-12
Identities = 55/179 (30%), Positives = 90/179 (50%), Gaps = 5/179 (2%)
Query: 156 LEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESF 215
L +L S + VDM + ++L L LS N +++LP +IG L L L ++DN L
Sbjct: 232 LVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTML 291
Query: 216 SVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLR 275
+ + +L L D S N++++LP L L+ L +D+N L + P +IG N+
Sbjct: 292 PNTIGNLSL---LEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVT 348
Query: 276 FLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQ-PKVLPVIKLQAPLTLLESSARTIL 332
+S NKL FLP E + L L+L N + P +K A L L ++ ++ ++
Sbjct: 349 VMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALI 407
Score = 68.9 bits (167), Expect = 8e-12
Identities = 52/154 (33%), Positives = 72/154 (46%), Gaps = 4/154 (2%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
+L+ L S G+ + C K L ++ S N I KLP L++L +L LND LE
Sbjct: 93 NLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEF 152
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
LR L+L +N +K LP +L +L+ L L +NE + P + Q+ NL
Sbjct: 153 LPANFGRLV---KLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNL 209
Query: 275 RFLSAARNKLPFLPSEFRNLS-LEYLDLFGNTFE 307
R L N L LP L L YLD+ N E
Sbjct: 210 RELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIE 243
Score = 62.4 bits (150), Expect = 7e-10
Identities = 45/133 (33%), Positives = 68/133 (51%), Gaps = 4/133 (3%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
L L +LDL +N +LP + + +L+EL +++N L+ ++ K L LD+SK
Sbjct: 183 LAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKL---KMLVYLDMSK 239
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLS 295
N+I+ + + + L++L L N L Q P IG L L L N+L LP+ NLS
Sbjct: 240 NRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLS 299
Query: 296 -LEYLDLFGNTFE 307
LE D N E
Sbjct: 300 LLEEFDCSCNELE 312
Score = 59.7 bits (143), Expect = 5e-09
Identities = 45/140 (32%), Positives = 71/140 (50%), Gaps = 3/140 (2%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
+LE L S L ++ + LK L L + N + LP TIG+L L+E + + N LES
Sbjct: 254 ALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELES 313
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
+ + SLR+L + +N + LP + + + + L N+L P +IGQ+ L
Sbjct: 314 LPSTIGY---LHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKL 370
Query: 275 RFLSAARNKLPFLPSEFRNL 294
R L+ + N+L LP F L
Sbjct: 371 RVLNLSDNRLKNLPFSFTKL 390
Score = 38.9 bits (89), Expect = 0.009
Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 4/99 (4%)
Query: 147 PLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELN 206
P + + +SL L L + + K++ + L N ++ LP IG + L+ LN
Sbjct: 315 PSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLN 374
Query: 207 LNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKAL-PVQ 244
L+DN L++ + T K L +L LS N+ KAL P+Q
Sbjct: 375 LSDNRLKNLPFSF---TKLKELAALWLSDNQSKALIPLQ 410
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 77.8 bits (190), Expect = 2e-14
Identities = 58/160 (36%), Positives = 80/160 (50%), Gaps = 11/160 (6%)
Query: 166 LVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQ 225
LV V M + SL L+L HN I+ +P I +L L LNL+ N L + LC L
Sbjct: 109 LVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLPL- 167
Query: 226 KSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLP 285
+ L S NK+ +LP + QL++L L + NE+ P +IGQL +LR L+ RN L
Sbjct: 168 ---KVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLK 224
Query: 286 FLPSEFRNLSLEYLDLFGN-------TFEQPKVLPVIKLQ 318
LP E +L L D N F + K L V+ L+
Sbjct: 225 VLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLE 264
Score = 55.8 bits (133), Expect = 7e-08
Identities = 38/106 (35%), Positives = 58/106 (54%), Gaps = 7/106 (6%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
LK L +LD+S N I LP IG L L+ELN+ N+L+ L L K D S
Sbjct: 187 LKQLMELDVSCNEITALPQQIGQLKSLRELNVRRNYLKVLPQELVDLPLVK----FDFSC 242
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFP---CKIGQLINLRFLS 278
NK+ +P+ F ++++L+ L L++N L P C G++ ++LS
Sbjct: 243 NKVLVIPICFREMKQLQVLLLENNPLQSPPAQICTKGKVHIFKYLS 288
Score = 40.8 bits (94), Expect = 0.002
Identities = 29/95 (30%), Positives = 44/95 (46%)
Query: 205 LNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQF 264
LNL+ L+ F DLSKN++ +P++ C L+ L L N +
Sbjct: 76 LNLSARKLKEFPRTAAPGHDLSDTVQADLSKNRLVEVPMELCHFVSLEILNLYHNCIRVI 135
Query: 265 PCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYL 299
P I L L +L+ +RN+L LP+ L L+ L
Sbjct: 136 PEAIVNLQMLTYLNLSRNQLSALPACLCGLPLKVL 170
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 76.6 bits (187), Expect = 4e-14
Identities = 57/163 (34%), Positives = 83/163 (50%), Gaps = 5/163 (3%)
Query: 152 FPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNH 211
F +LE L + + ++ +SL KL L N + LPA+I +LI+L+EL+++ N
Sbjct: 44 FEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG 103
Query: 212 LESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQL 271
++ F + + K L ++ S N I LP F QL L L L+D L P G+L
Sbjct: 104 IQEFPENIKNC---KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRL 160
Query: 272 INLRFLSAARNKLPFLPSEFRNLS-LEYLDLFGNTF-EQPKVL 312
L+ L N+L LP L+ LE LDL N F E P+VL
Sbjct: 161 TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Score = 64.3 bits (155), Expect = 2e-10
Identities = 47/150 (31%), Positives = 76/150 (50%), Gaps = 4/150 (2%)
Query: 156 LEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESF 215
L +L S + V+ + ++L+ L LS N +++LP TIG L ++ L +++N L
Sbjct: 232 LTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291
Query: 216 SVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLR 275
++ S+ LD S N+++ALP QL L+ D N L Q P +IG N+
Sbjct: 292 PDSIGGLI---SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNIT 348
Query: 276 FLSAARNKLPFLPSEFRNL-SLEYLDLFGN 304
L NKL LP E ++ L+ ++L N
Sbjct: 349 VLFLHSNKLETLPEEMGDMQKLKVINLSDN 378
Score = 60.5 bits (145), Expect = 3e-09
Identities = 48/173 (27%), Positives = 82/173 (47%), Gaps = 10/173 (5%)
Query: 123 LTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKL 182
LT ++ E + KM+ P + N LE L V + L L++
Sbjct: 160 LTKLQILELRENQLKML-------PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 183 DLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALP 242
+ N + +P IG L L L+++ N++E + ST + +L+ L LS N ++ LP
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGI--STCE-NLQDLLLSSNSLQQLP 269
Query: 243 VQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLS 295
L+ + LK+D+N+L+ P IG LI++ L + N++ LPS L+
Sbjct: 270 ETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
Score = 54.7 bits (130), Expect = 2e-07
Identities = 33/95 (34%), Positives = 45/95 (47%), Gaps = 7/95 (7%)
Query: 223 TLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARN 282
T +K+L L L N+I+ LP Q Q L L L DN+L P I LINLR L ++N
Sbjct: 43 TFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKN 102
Query: 283 KLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVIKL 317
+ P +N + T + V P+ KL
Sbjct: 103 GIQEFPENIKNCKV-------LTIVEASVNPISKL 130
Score = 53.9 bits (128), Expect = 3e-07
Identities = 37/140 (26%), Positives = 71/140 (50%), Gaps = 3/140 (2%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
+L+ L S L ++ + LK++ L + N + LP +IG LI ++EL+ + N +E+
Sbjct: 254 NLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEA 313
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
++ T +LR+ N ++ LP + + + L L N+L P ++G + L
Sbjct: 314 LPSSIGQLT---NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKL 370
Query: 275 RFLSAARNKLPFLPSEFRNL 294
+ ++ + N+L LP F L
Sbjct: 371 KVINLSDNRLKNLPFSFTKL 390
Score = 52.4 bits (124), Expect = 8e-07
Identities = 34/114 (29%), Positives = 59/114 (51%), Gaps = 4/114 (3%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
L S+ +LD S N ++ LP++IG L +L+ + N+L+ + K++ L L
Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGS---WKNITVLFLHS 354
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNK-LPFLP 288
NK++ LP + +Q+LK + L DN L P +L L + + N+ P +P
Sbjct: 355 NKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP 408
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 76.6 bits (187), Expect = 4e-14
Identities = 57/163 (34%), Positives = 83/163 (50%), Gaps = 5/163 (3%)
Query: 152 FPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNH 211
F +LE L + + ++ +SL KL L N + LPA+I +LI+L+EL+++ N
Sbjct: 44 FEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNG 103
Query: 212 LESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQL 271
++ F + + K L ++ S N I LP F QL L L L+D L P G+L
Sbjct: 104 IQEFPENIKNC---KVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRL 160
Query: 272 INLRFLSAARNKLPFLPSEFRNLS-LEYLDLFGNTF-EQPKVL 312
L+ L N+L LP L+ LE LDL N F E P+VL
Sbjct: 161 TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVL 203
Score = 64.3 bits (155), Expect = 2e-10
Identities = 47/150 (31%), Positives = 76/150 (50%), Gaps = 4/150 (2%)
Query: 156 LEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESF 215
L +L S + V+ + ++L+ L LS N +++LP TIG L ++ L +++N L
Sbjct: 232 LTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYL 291
Query: 216 SVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLR 275
++ S+ LD S N+++ALP QL L+ D N L Q P +IG N+
Sbjct: 292 PDSIGGLI---SVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNIT 348
Query: 276 FLSAARNKLPFLPSEFRNL-SLEYLDLFGN 304
L NKL LP E ++ L+ ++L N
Sbjct: 349 VLFLHSNKLETLPEEMGDMQKLKVINLSDN 378
Score = 60.5 bits (145), Expect = 3e-09
Identities = 48/173 (27%), Positives = 82/173 (47%), Gaps = 10/173 (5%)
Query: 123 LTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKL 182
LT ++ E + KM+ P + N LE L V + L L++
Sbjct: 160 LTKLQILELRENQLKML-------PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEF 212
Query: 183 DLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALP 242
+ N + +P IG L L L+++ N++E + ST + +L+ L LS N ++ LP
Sbjct: 213 WMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGI--STCE-NLQDLLLSSNSLQQLP 269
Query: 243 VQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLS 295
L+ + LK+D+N+L+ P IG LI++ L + N++ LPS L+
Sbjct: 270 ETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLT 322
Score = 54.7 bits (130), Expect = 2e-07
Identities = 33/95 (34%), Positives = 45/95 (47%), Gaps = 7/95 (7%)
Query: 223 TLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARN 282
T +K+L L L N+I+ LP Q Q L L L DN+L P I LINLR L ++N
Sbjct: 43 TFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKN 102
Query: 283 KLPFLPSEFRNLSLEYLDLFGNTFEQPKVLPVIKL 317
+ P +N + T + V P+ KL
Sbjct: 103 GIQEFPENIKNCKV-------LTIVEASVNPISKL 130
Score = 53.9 bits (128), Expect = 3e-07
Identities = 37/140 (26%), Positives = 71/140 (50%), Gaps = 3/140 (2%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
+L+ L S L ++ + LK++ L + N + LP +IG LI ++EL+ + N +E+
Sbjct: 254 NLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEA 313
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
++ T +LR+ N ++ LP + + + L L N+L P ++G + L
Sbjct: 314 LPSSIGQLT---NLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKL 370
Query: 275 RFLSAARNKLPFLPSEFRNL 294
+ ++ + N+L LP F L
Sbjct: 371 KVINLSDNRLKNLPFSFTKL 390
Score = 52.4 bits (124), Expect = 8e-07
Identities = 34/114 (29%), Positives = 59/114 (51%), Gaps = 4/114 (3%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
L S+ +LD S N ++ LP++IG L +L+ + N+L+ + K++ L L
Sbjct: 298 LISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGS---WKNITVLFLHS 354
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNK-LPFLP 288
NK++ LP + +Q+LK + L DN L P +L L + + N+ P +P
Sbjct: 355 NKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP 408
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 75.1 bits (183), Expect = 1e-13
Identities = 62/196 (31%), Positives = 93/196 (47%), Gaps = 24/196 (12%)
Query: 147 PLSKNFPYSLEHLQTSYCGLVRVDMRML-CLKSLRKLDLSHNHIKKLPATIGDLIHLQEL 205
P + L L S+ L + ++ L+ LRKL+LSHN + LPA +G L HL+EL
Sbjct: 104 PAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEEL 163
Query: 206 NLNDNHLESFSVAL-CHSTLQK-------------------SLRSLDLSKNKIKALPVQF 245
+++ N L +L C S L+ +L LD+S N+++ LP
Sbjct: 164 DVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDI 223
Query: 246 CQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLS-LEYLDLFGN 304
L+ LK L L EL P +L +L L N L LP++F L L+ L+L N
Sbjct: 224 SALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSN 283
Query: 305 TFEQ--PKVLPVIKLQ 318
FE+ +LP+ L+
Sbjct: 284 LFEEFPAALLPLAGLE 299
Score = 70.1 bits (170), Expect = 4e-12
Identities = 49/154 (31%), Positives = 68/154 (44%), Gaps = 20/154 (12%)
Query: 156 LEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESF 215
LE L S+ L + + CL LR LD+ HN + P + L+ L+EL+++ N L
Sbjct: 160 LEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGL 219
Query: 216 SVALCHSTLQK--------------------SLRSLDLSKNKIKALPVQFCQLQELKNLK 255
+ K SL SL L N ++ALP QF LQ LK L
Sbjct: 220 PEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLN 279
Query: 256 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPS 289
L N +FP + L L L +RN+L +PS
Sbjct: 280 LSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPS 313
Score = 63.5 bits (153), Expect = 3e-10
Identities = 45/131 (34%), Positives = 65/131 (49%), Gaps = 4/131 (3%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDL-IHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLS 234
L SLR L L N +LP + +L HL EL+++ N L + + + + LR L+LS
Sbjct: 86 LGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSAL--RELRKLNLS 143
Query: 235 KNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL 294
N++ ALP Q L L+ L + N L P + L LR L N+L P + L
Sbjct: 144 HNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQL 203
Query: 295 -SLEYLDLFGN 304
+LE LD+ N
Sbjct: 204 VALEELDVSSN 214
Score = 60.5 bits (145), Expect = 3e-09
Identities = 52/165 (31%), Positives = 76/165 (46%), Gaps = 5/165 (3%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
SLE L GL + + CL+ L+ L+LS N ++ PA + L L+EL L+ N L S
Sbjct: 251 SLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTS 310
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
+ S L + L +L L N+I+ LP +L L+ L L N++ P GQL +
Sbjct: 311 VPSLI--SGLGRLL-TLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRV 367
Query: 275 RFLSAARNKLPFLPSEFRNLSLEYLDLFGN--TFEQPKVLPVIKL 317
N L P E + Y+ + QP V P +KL
Sbjct: 368 GLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKL 412
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 73.9 bits (180), Expect = 2e-13
Identities = 59/162 (36%), Positives = 78/162 (48%), Gaps = 11/162 (6%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
SLE L L + L +LRKL LS N I++LP + + + L EL+++ N +
Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
Query: 215 F--SVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLI 272
S+ C K+L D S N + LP F QL+ L +L L+D L P +G L
Sbjct: 97 IPESIKFC-----KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLA 151
Query: 273 NLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQPKVLP 313
NL L N L LP+ L LE LDL GN E VLP
Sbjct: 152 NLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLE---VLP 190
Score = 67.4 bits (163), Expect = 2e-11
Identities = 59/179 (32%), Positives = 90/179 (50%), Gaps = 23/179 (12%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDN----------HLESFSVA------L 219
L+ L LD+S N +++LPA +G L+ L +L L+ N L+ S+ L
Sbjct: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Query: 220 CHSTLQ----KSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLR 275
C T ++L L L++N + ALP +L +L NL +D N L P +IG + L
Sbjct: 279 CEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALS 338
Query: 276 FLSAARNKLPFLPSEFRNLS-LEYLDLFGNTFEQ-PKVLPVIKLQAPLTLLESSARTIL 332
LS N+L LP E + + L LD+ GN + P L + L+A L L E+ A+ +L
Sbjct: 339 VLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKA-LWLAENQAQPML 396
Score = 66.2 bits (160), Expect = 5e-11
Identities = 60/196 (30%), Positives = 89/196 (45%), Gaps = 4/196 (2%)
Query: 101 KGFLSAMRLAHRGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQ 160
K F + L G + D + L P + + + + + P S F +LE
Sbjct: 53 KPFFRLLNLRKLGLS-DNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIAD 111
Query: 161 TSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALC 220
S L R+ L+SL L L+ ++ LP +G+L +L L L +N L+S +L
Sbjct: 112 FSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL- 170
Query: 221 HSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAA 280
S L K L LDL N ++ LP L L+ L LD N+L P ++G L L L +
Sbjct: 171 -SFLVK-LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVS 228
Query: 281 RNKLPFLPSEFRNLSL 296
N+L LP+E L L
Sbjct: 229 ENRLEELPAELGGLVL 244
Score = 62.0 bits (149), Expect = 1e-09
Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 6/149 (4%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
SL HL + L + + L +L L+L N +K LPA++ L+ L++L+L N LE
Sbjct: 129 SLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
L +LR L L +N++ ALP + L+ L L + +N L + P ++G L+ L
Sbjct: 189 LPDTL---GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLL 245
Query: 275 RFLSAARNKLPFLP---SEFRNLSLEYLD 300
L ++N L LP + + LS+ +D
Sbjct: 246 TDLLLSQNLLRRLPDGIGQLKQLSILKVD 274
Score = 60.8 bits (146), Expect = 2e-09
Identities = 53/157 (33%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 177 KSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKN 236
K+L D S N + +LP L L L LND L++ + + +L +L+L +N
Sbjct: 105 KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLA---NLVTLELREN 161
Query: 237 KIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-S 295
+K+LP L +L+ L L N+L P +G L NLR L RN+L LP E NL
Sbjct: 162 LLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRR 221
Query: 296 LEYLDLFGNTFEQ-PKVLPVIKLQAPLTLLESSARTI 331
L LD+ N E+ P L + L L L ++ R +
Sbjct: 222 LVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRL 258
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 9/110 (8%)
Query: 226 KSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLP 285
+SL L L N+++ LP F +L L+ L L DNE+ + P ++ + L L +RN +P
Sbjct: 36 RSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIP 95
Query: 286 FLPSEFRNL-SLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTILHN 334
+P + +LE D GN P+ +L T L S A L++
Sbjct: 96 EIPESIKFCKALEIADFSGN--------PLSRLPDGFTQLRSLAHLALND 137
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 73.9 bits (180), Expect = 2e-13
Identities = 59/162 (36%), Positives = 78/162 (48%), Gaps = 11/162 (6%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
SLE L L + L +LRKL LS N I++LP + + + L EL+++ N +
Sbjct: 37 SLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPE 96
Query: 215 F--SVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLI 272
S+ C K+L D S N + LP F QL+ L +L L+D L P +G L
Sbjct: 97 IPESIKFC-----KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLA 151
Query: 273 NLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQPKVLP 313
NL L N L LP+ L LE LDL GN E VLP
Sbjct: 152 NLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLE---VLP 190
Score = 67.4 bits (163), Expect = 2e-11
Identities = 59/179 (32%), Positives = 90/179 (50%), Gaps = 23/179 (12%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDN----------HLESFSVA------L 219
L+ L LD+S N +++LPA +G L+ L +L L+ N L+ S+ L
Sbjct: 219 LRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRL 278
Query: 220 CHSTLQ----KSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLR 275
C T ++L L L++N + ALP +L +L NL +D N L P +IG + L
Sbjct: 279 CEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALS 338
Query: 276 FLSAARNKLPFLPSEFRNLS-LEYLDLFGNTFEQ-PKVLPVIKLQAPLTLLESSARTIL 332
LS N+L LP E + + L LD+ GN + P L + L+A L L E+ A+ +L
Sbjct: 339 VLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKA-LWLAENQAQPML 396
Score = 66.2 bits (160), Expect = 5e-11
Identities = 60/196 (30%), Positives = 89/196 (45%), Gaps = 4/196 (2%)
Query: 101 KGFLSAMRLAHRGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQ 160
K F + L G + D + L P + + + + + P S F +LE
Sbjct: 53 KPFFRLLNLRKLGLS-DNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIAD 111
Query: 161 TSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALC 220
S L R+ L+SL L L+ ++ LP +G+L +L L L +N L+S +L
Sbjct: 112 FSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASL- 170
Query: 221 HSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAA 280
S L K L LDL N ++ LP L L+ L LD N+L P ++G L L L +
Sbjct: 171 -SFLVK-LEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVS 228
Query: 281 RNKLPFLPSEFRNLSL 296
N+L LP+E L L
Sbjct: 229 ENRLEELPAELGGLVL 244
Score = 62.0 bits (149), Expect = 1e-09
Identities = 47/149 (31%), Positives = 77/149 (51%), Gaps = 6/149 (4%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
SL HL + L + + L +L L+L N +K LPA++ L+ L++L+L N LE
Sbjct: 129 SLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEV 188
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
L +LR L L +N++ ALP + L+ L L + +N L + P ++G L+ L
Sbjct: 189 LPDTL---GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLL 245
Query: 275 RFLSAARNKLPFLP---SEFRNLSLEYLD 300
L ++N L LP + + LS+ +D
Sbjct: 246 TDLLLSQNLLRRLPDGIGQLKQLSILKVD 274
Score = 60.8 bits (146), Expect = 2e-09
Identities = 53/157 (33%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 177 KSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKN 236
K+L D S N + +LP L L L LND L++ + + +L +L+L +N
Sbjct: 105 KALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLA---NLVTLELREN 161
Query: 237 KIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-S 295
+K+LP L +L+ L L N+L P +G L NLR L RN+L LP E NL
Sbjct: 162 LLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRR 221
Query: 296 LEYLDLFGNTFEQ-PKVLPVIKLQAPLTLLESSARTI 331
L LD+ N E+ P L + L L L ++ R +
Sbjct: 222 LVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRL 258
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 9/110 (8%)
Query: 226 KSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLP 285
+SL L L N+++ LP F +L L+ L L DNE+ + P ++ + L L +RN +P
Sbjct: 36 RSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIP 95
Query: 286 FLPSEFRNL-SLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTILHN 334
+P + +LE D GN P+ +L T L S A L++
Sbjct: 96 EIPESIKFCKALEIADFSGN--------PLSRLPDGFTQLRSLAHLALND 137
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 73.6 bits (179), Expect = 3e-13
Identities = 55/153 (35%), Positives = 74/153 (48%), Gaps = 8/153 (5%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
SLE L L + + L LRKL LS N I++LP I + + L EL+++ N +
Sbjct: 37 SLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIPE 96
Query: 215 F--SVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLI 272
S++ C K+L+ D S N + LP F +LQ L L ++D L P IG L
Sbjct: 97 IPESISFC-----KALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLY 151
Query: 273 NLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGN 304
NL L N L +LP L LE LDL N
Sbjct: 152 NLASLELRENLLTYLPDSLTQLRRLEELDLGNN 184
Score = 68.2 bits (165), Expect = 1e-11
Identities = 57/193 (29%), Positives = 89/193 (46%), Gaps = 4/193 (2%)
Query: 103 FLSAMRLAHRGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTS 162
F ++L G + D + L P + + + + + P S +F +L+ S
Sbjct: 55 FFQLVKLRKLGLS-DNEIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFS 113
Query: 163 YCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHS 222
L R+ L++L L ++ ++ LP IG+L +L L L +N L +L
Sbjct: 114 GNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSL--- 170
Query: 223 TLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARN 282
T + L LDL N+I LP L LK+L LD N+L + P +IG L NL L + N
Sbjct: 171 TQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSEN 230
Query: 283 KLPFLPSEFRNLS 295
+L LP E L+
Sbjct: 231 RLERLPEEISGLT 243
Score = 64.3 bits (155), Expect = 2e-10
Identities = 54/176 (30%), Positives = 87/176 (49%), Gaps = 6/176 (3%)
Query: 159 LQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVA 218
L S L R+ + L SL L +S N ++ +P IG L L L ++ N L A
Sbjct: 225 LDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEA 284
Query: 219 LCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLS 278
+ +SL L L++N++ LP +L++L NL D N+L+ P +IG +L
Sbjct: 285 VGEC---ESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC 341
Query: 279 AARNKLPFLPSEFRNLS-LEYLDLFGN-TFEQPKVLPVIKLQAPLTLLESSARTIL 332
N+L +P+E + L LD+ GN P L +KL+A L L ++ ++ +L
Sbjct: 342 VRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKA-LWLSDNQSQPLL 396
Score = 63.5 bits (153), Expect = 3e-10
Identities = 41/115 (35%), Positives = 62/115 (53%), Gaps = 3/115 (2%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
LK+L LD+S N +++LP I L L +L ++ N LE+ + K L L + +
Sbjct: 219 LKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKL---KKLSILKVDQ 275
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSE 290
N++ LP + + L L L +N+L+ P IG+L L L+A RNKL LP E
Sbjct: 276 NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKE 330
Score = 53.9 bits (128), Expect = 3e-07
Identities = 34/111 (30%), Positives = 60/111 (54%), Gaps = 2/111 (1%)
Query: 226 KSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLP 285
+SL L L N+++ LP QF QL +L+ L L DNE+ + P +I + L L +RN++P
Sbjct: 36 RSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEIP 95
Query: 286 FLPSEFRNL-SLEYLDLFGNTFEQ-PKVLPVIKLQAPLTLLESSARTILHN 334
+P +L+ D GN + P+ P ++ L++ + S +++ N
Sbjct: 96 EIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 72.4 bits (176), Expect = 7e-13
Identities = 83/307 (27%), Positives = 123/307 (40%), Gaps = 66/307 (21%)
Query: 62 LRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISS-SLKGFLSA-------------- 106
LREN+ KF D +KE P+ I K + L G LSA
Sbjct: 491 LRENLRALHIKFTD-------IKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543
Query: 107 --MRLAHRGCNVDTPVSTLTPV----KTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQ 160
+++ N+ +T V + N TK+++ + S +L L+
Sbjct: 544 KRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLN------SLKKMANLTELE 597
Query: 161 TSYCGLVRVDMRMLCLKSLRKLDLS-------------------------HNHIKKLPAT 195
C L R+ + L +L+++DL +NHI +P
Sbjct: 598 LIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ 657
Query: 196 IGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLK 255
IG+L +L+ L LN N +E L + + LR LDLS N + LP LQ L+NL
Sbjct: 658 IGNLTNLERLYLNRNKIEKIPTQLFYC---RKLRYLDLSHNNLTFLPADIGLLQNLQNLA 714
Query: 256 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQPKVLPV 314
+ N + P ++ Q LR L N L LPS L +L ++L GN E LPV
Sbjct: 715 ITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE---CLPV 771
Query: 315 IKLQAPL 321
+ PL
Sbjct: 772 ELGECPL 778
Score = 36.2 bits (82), Expect = 0.056
Identities = 18/50 (36%), Positives = 28/50 (56%)
Query: 177 KSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQK 226
+ LR L L +N ++ LP+ +G+L +L ++ L N LE V L L K
Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 72.4 bits (176), Expect = 7e-13
Identities = 83/307 (27%), Positives = 123/307 (40%), Gaps = 66/307 (21%)
Query: 62 LRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISS-SLKGFLSA-------------- 106
LREN+ KF D +KE P+ I K + L G LSA
Sbjct: 491 LRENLRALHIKFTD-------IKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543
Query: 107 --MRLAHRGCNVDTPVSTLTPV----KTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQ 160
+++ N+ +T V + N TK+++ + S +L L+
Sbjct: 544 KRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLN------SLKKMANLTELE 597
Query: 161 TSYCGLVRVDMRMLCLKSLRKLDLS-------------------------HNHIKKLPAT 195
C L R+ + L +L+++DL +NHI +P
Sbjct: 598 LIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ 657
Query: 196 IGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLK 255
IG+L +L+ L LN N +E L + + LR LDLS N + LP LQ L+NL
Sbjct: 658 IGNLTNLERLYLNRNKIEKIPTQLFYC---RKLRYLDLSHNNLTFLPADIGLLQNLQNLA 714
Query: 256 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQPKVLPV 314
+ N + P ++ Q LR L N L LPS L +L ++L GN E LPV
Sbjct: 715 ITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE---CLPV 771
Query: 315 IKLQAPL 321
+ PL
Sbjct: 772 ELGECPL 778
Score = 36.2 bits (82), Expect = 0.056
Identities = 18/50 (36%), Positives = 28/50 (56%)
Query: 177 KSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQK 226
+ LR L L +N ++ LP+ +G+L +L ++ L N LE V L L K
Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 72.4 bits (176), Expect = 7e-13
Identities = 83/307 (27%), Positives = 123/307 (40%), Gaps = 66/307 (21%)
Query: 62 LRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISS-SLKGFLSA-------------- 106
LREN+ KF D +KE P+ I K + L G LSA
Sbjct: 491 LRENLRALHIKFTD-------IKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLREL 543
Query: 107 --MRLAHRGCNVDTPVSTLTPV----KTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQ 160
+++ N+ +T V + N TK+++ + S +L L+
Sbjct: 544 KRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLN------SLKKMANLTELE 597
Query: 161 TSYCGLVRVDMRMLCLKSLRKLDLS-------------------------HNHIKKLPAT 195
C L R+ + L +L+++DL +NHI +P
Sbjct: 598 LIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQ 657
Query: 196 IGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLK 255
IG+L +L+ L LN N +E L + + LR LDLS N + LP LQ L+NL
Sbjct: 658 IGNLTNLERLYLNRNKIEKIPTQLFYC---RKLRYLDLSHNNLTFLPADIGLLQNLQNLA 714
Query: 256 LDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQPKVLPV 314
+ N + P ++ Q LR L N L LPS L +L ++L GN E LPV
Sbjct: 715 ITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE---CLPV 771
Query: 315 IKLQAPL 321
+ PL
Sbjct: 772 ELGECPL 778
Score = 36.2 bits (82), Expect = 0.056
Identities = 18/50 (36%), Positives = 28/50 (56%)
Query: 177 KSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQK 226
+ LR L L +N ++ LP+ +G+L +L ++ L N LE V L L K
Sbjct: 731 RKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 72.0 bits (175), Expect = 9e-13
Identities = 54/153 (35%), Positives = 80/153 (52%), Gaps = 4/153 (2%)
Query: 157 EHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFS 216
+ L+ S L R+ + L L+KL +S +++LP I +L L+ L L+ N LE
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 217 VALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRF 276
LC L L L N++ ALP F QLQ L+ L ++ N L +FP + +L+ L+
Sbjct: 84 DGLCRLP---RLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQS 140
Query: 277 LSAARNKLPFLPSEF-RNLSLEYLDLFGNTFEQ 308
L N+L LP+E R L L L+GN FE+
Sbjct: 141 LQMGDNRLRALPAELPRMTGLRGLWLYGNRFEE 173
Score = 47.4 bits (111), Expect = 2e-05
Identities = 36/116 (31%), Positives = 55/116 (47%), Gaps = 4/116 (3%)
Query: 174 LC-LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLD 232
LC L L +L L N + LPA L L+ L + N L F L +L+SL
Sbjct: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLV---ALQSLQ 142
Query: 233 LSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLP 288
+ N+++ALP + ++ L+ L L N +FP + ++ L L RN+L P
Sbjct: 143 MGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
Score = 38.1 bits (87), Expect = 0.015
Identities = 31/88 (35%), Positives = 43/88 (48%), Gaps = 5/88 (5%)
Query: 222 STLQKSLRS----LDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFL 277
S ++ LRS L+LS +++ LP C L L+ L + L + P +I +L LR L
Sbjct: 13 SDAEEQLRSGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRIL 72
Query: 278 SAARNKLPFLPSEFRNL-SLEYLDLFGN 304
+ NKL LP L L L L GN
Sbjct: 73 ALDFNKLERLPDGLCRLPRLTRLYLGGN 100
Score = 35.0 bits (79), Expect = 0.12
Identities = 28/94 (29%), Positives = 42/94 (44%), Gaps = 4/94 (4%)
Query: 166 LVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQ 225
L R +L L +L+ L + N ++ LPA + + L+ L L N E F AL
Sbjct: 125 LRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLR---M 181
Query: 226 KSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDN 259
L LDL +N++ P L+ L+ D N
Sbjct: 182 GRLHILDLDRNRLGGFP-DLHPLRALRVFSYDHN 214
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 70.9 bits (172), Expect = 2e-12
Identities = 48/128 (37%), Positives = 72/128 (56%), Gaps = 4/128 (3%)
Query: 178 SLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNK 237
S+ +L+L+ N + K+P + L+ L+ L L++N L+ L L+K LR LDL +NK
Sbjct: 403 SMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGL--GNLRK-LRELDLEENK 459
Query: 238 IKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SL 296
+++LP + L++L+ L L +N+L P IG L NL L N L LP E L +L
Sbjct: 460 LESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENL 519
Query: 297 EYLDLFGN 304
E L L N
Sbjct: 520 EELYLNDN 527
Score = 63.5 bits (153), Expect = 3e-10
Identities = 50/153 (32%), Positives = 76/153 (49%), Gaps = 27/153 (17%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
L L +L L N ++ LPA +G L++L L L++N L S +L + K LR LDL
Sbjct: 122 LTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNL---KKLRMLDLRH 178
Query: 236 NKIKALPVQFCQL-----------------QELKNLK------LDDNELIQFPCKIGQLI 272
NK++ +P +L +++KNL + +N++ Q P +IG+L
Sbjct: 179 NKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELC 238
Query: 273 NLRFLSAARNKLPFLPSEFRNLS-LEYLDLFGN 304
NL L A N+L LP E N + + LDL N
Sbjct: 239 NLITLDVAHNQLEHLPKEIGNCTQITNLDLQHN 271
Score = 60.8 bits (146), Expect = 2e-09
Identities = 52/150 (34%), Positives = 76/150 (50%), Gaps = 10/150 (6%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
S+ L + L ++ + L SL L LS+N +KKLP +G+L L+EL+L +N LES
Sbjct: 403 SMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLES 462
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
+ + K L+ L L+ N++ LP L L +L L +N L P +IG L NL
Sbjct: 463 LPNEIAY---LKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENL 519
Query: 275 RFLSAARN----KLPF---LPSEFRNLSLE 297
L N LPF L S+ +S+E
Sbjct: 520 EELYLNDNPNLHSLPFELALCSKLSIMSIE 549
Score = 58.2 bits (139), Expect = 1e-08
Identities = 55/191 (28%), Positives = 83/191 (43%), Gaps = 11/191 (5%)
Query: 154 YSLEHLQTSYCGLVRVDMRMLCLKSLRKLDL---SHNHIKKLPATIGDLIHLQELNLNDN 210
Y L+ L T Y R+ +K+L KL + N IK+LPA IG+L +L L++ N
Sbjct: 189 YRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHN 248
Query: 211 HLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQ 270
LE + + T + +LDL N++ LP L L L L N L P + +
Sbjct: 249 QLEHLPKEIGNCT---QITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAK 305
Query: 271 LINLRFLSAARNKLPFLPSEFRN--LSLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSA 328
L L+ N + LP + + L L L N F+ + PV T+ +
Sbjct: 306 CSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ---LYPVGGPSQFSTIYSLNM 362
Query: 329 RTILHNRIPYG 339
N+IP+G
Sbjct: 363 EHNRINKIPFG 373
Score = 56.6 bits (135), Expect = 4e-08
Identities = 48/172 (27%), Positives = 83/172 (48%), Gaps = 25/172 (14%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFS-----------VALCHSTL 224
LK LR LDL HN ++++P+ + L L L L N + + +++ + +
Sbjct: 168 LKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKI 227
Query: 225 QK---------SLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLR 275
++ +L +LD++ N+++ LP + ++ NL L NEL+ P IG L +L
Sbjct: 228 KQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLS 287
Query: 276 FLSAARNKLPFLPSEFRNLS-LEYLDLFGN---TFEQPKVLPVIKLQAPLTL 323
L N+L +P S LE L+L N T + + ++KL + LTL
Sbjct: 288 RLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNS-LTL 338
Score = 51.2 bits (121), Expect = 2e-06
Identities = 51/202 (25%), Positives = 83/202 (41%), Gaps = 25/202 (12%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATI-GDLIHLQELNLNDNHLE 213
SL L Y L + + +L +L+L +N+I LP ++ L+ L L L N +
Sbjct: 285 SLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQ 344
Query: 214 SFSVA------------LCHSTLQKS----------LRSLDLSKNKIKALPVQFCQLQEL 251
+ V + H+ + K L L++ N++ +LP+ F +
Sbjct: 345 LYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSM 404
Query: 252 KNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQ-P 309
L L N+L + P + L++L L + N L LP NL L LDL N E P
Sbjct: 405 VELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLP 464
Query: 310 KVLPVIKLQAPLTLLESSARTI 331
+ +K L L + T+
Sbjct: 465 NEIAYLKDLQKLVLTNNQLTTL 486
Score = 50.8 bits (120), Expect = 2e-06
Identities = 40/101 (39%), Positives = 52/101 (51%), Gaps = 5/101 (4%)
Query: 225 QKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKL 284
+ S+R LDLSK I LP +L +L L L N+L P ++G L+NL L+ + N L
Sbjct: 100 ENSMR-LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSL 158
Query: 285 PFLPSEFRNL-SLEYLDLFGNTF-EQPKVLPVIKLQAPLTL 323
LP NL L LDL N E P V V +L + TL
Sbjct: 159 TSLPDSLDNLKKLRMLDLRHNKLREIPSV--VYRLDSLTTL 197
>gi|63003903 leucine rich repeat containing 10 [Homo sapiens]
Length = 277
Score = 69.7 bits (169), Expect = 5e-12
Identities = 59/183 (32%), Positives = 85/183 (46%), Gaps = 14/183 (7%)
Query: 139 VITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGD 198
V+ ++ PL K S L+ R + + + L KL LS NH+ LP +G
Sbjct: 21 VVRDLREMPLDKMVDLSGSQLR-------RFPLHVCSFRELVKLYLSDNHLNSLPPELGQ 73
Query: 199 LIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDD 258
L +LQ L L+ N+ ++ +C TL K L L L NK+ LP + LQ L+ L ++
Sbjct: 74 LQNLQILALDFNNFKALPQVVC--TL-KQLCILYLGNNKLCDLPSELSLLQNLRTLWIEA 130
Query: 259 NELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQPKVLPVIKL 317
N L Q P + +L L+ L A N L LP + R L L + L GN P + L
Sbjct: 131 NCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTD---FPTVLL 187
Query: 318 QAP 320
P
Sbjct: 188 HMP 190
Score = 48.9 bits (115), Expect = 8e-06
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 3/114 (2%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
LK L L L +N + LP+ + L +L+ L + N L +C +L K+L +
Sbjct: 97 LKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHA---GS 153
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPS 289
N ++ LP Q +LQEL+ + L N L FP + + L + N + + PS
Sbjct: 154 NALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPS 207
Score = 45.4 bits (106), Expect = 9e-05
Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 6/75 (8%)
Query: 220 CHSTLQKSLRSL------DLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLIN 273
C + + + LR + DLS ++++ P+ C +EL L L DN L P ++GQL N
Sbjct: 17 CQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQN 76
Query: 274 LRFLSAARNKLPFLP 288
L+ L+ N LP
Sbjct: 77 LQILALDFNNFKALP 91
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 69.7 bits (169), Expect = 5e-12
Identities = 51/153 (33%), Positives = 78/153 (50%), Gaps = 6/153 (3%)
Query: 155 SLEHLQTSYCGLVRVDMRMLC-LKSLRKLDLSHNHIKKLPATI-GDLIHLQELNLNDNHL 212
SLE L SY + + ++ L +LR+L L +K++P I +L HL+ L L NHL
Sbjct: 95 SLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHL 154
Query: 213 ESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLI 272
+ + + T LR + L +N+ + P + C L L+ + LD+N++ P +IG L
Sbjct: 155 KCLPKEIVNQT---KLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLT 211
Query: 273 NLRFLSAARNKLPFLPSEFRNLS-LEYLDLFGN 304
L+ A N LP LP+ S L LDL N
Sbjct: 212 GLQKFYMASNNLPVLPASLCQCSQLSVLDLSHN 244
Score = 69.7 bits (169), Expect = 5e-12
Identities = 47/142 (33%), Positives = 68/142 (47%), Gaps = 21/142 (14%)
Query: 179 LRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQK------------ 226
L LDLSHN + +P + +L + E+ L+ N LE +C T
Sbjct: 236 LSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRL 295
Query: 227 --------SLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLS 278
+LR LDLS+N + P+Q C L+ L+ L LDDN++ Q P ++G L L+ L
Sbjct: 296 RGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILG 355
Query: 279 AARNKLPFLPSEFRNL-SLEYL 299
N+ P E +L SLE L
Sbjct: 356 LTGNEFLSFPEEVLSLASLEKL 377
Score = 63.9 bits (154), Expect = 3e-10
Identities = 45/121 (37%), Positives = 61/121 (50%), Gaps = 6/121 (4%)
Query: 173 MLCLKSLRKLDLSHNHIKKL---PATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLR 229
+L L SL KL + + KL P I L L+EL + +NHLE V+L +L
Sbjct: 368 VLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGS---MPNLE 424
Query: 230 SLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPS 289
LD N +K LP CQ Q LK L+L+DN L P + L+NL+ L+ N + P
Sbjct: 425 VLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPK 484
Query: 290 E 290
E
Sbjct: 485 E 485
Score = 60.5 bits (145), Expect = 3e-09
Identities = 43/134 (32%), Positives = 62/134 (46%), Gaps = 4/134 (2%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
L L L L+ NH+K LP I + L+E+ L N E F LC + +L +DL +
Sbjct: 141 LHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELC---VLYTLEIIDLDE 197
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL- 294
NKI A+P + L L+ + N L P + Q L L + N L +P F L
Sbjct: 198 NKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELR 257
Query: 295 SLEYLDLFGNTFEQ 308
+ + L GN E+
Sbjct: 258 KMTEIGLSGNRLEK 271
Score = 57.8 bits (138), Expect = 2e-08
Identities = 51/158 (32%), Positives = 76/158 (48%), Gaps = 7/158 (4%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
SL L GL R+ CL +LR LDLS NH+ P I L +L+ L L+DN +
Sbjct: 281 SLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQ 340
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNE---LIQFPCKIGQL 271
L +L K L+ L L+ N+ + P + L L+ L + ++ L P I +L
Sbjct: 341 LPSEL--GSLSK-LKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKL 397
Query: 272 INLRFLSAARNKLPFLPSEFRNL-SLEYLDLFGNTFEQ 308
+L+ L N L +LP ++ +LE LD N +Q
Sbjct: 398 QSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQ 435
Score = 40.4 bits (93), Expect = 0.003
Identities = 28/90 (31%), Positives = 47/90 (52%), Gaps = 1/90 (1%)
Query: 231 LDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFL-PS 289
+D S + A+P++ EL+ + L++N++ + P +I +L N+R L +N L L P+
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 290 EFRNLSLEYLDLFGNTFEQPKVLPVIKLQA 319
SLE LDL N ++ V L A
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHA 119
Score = 28.9 bits (63), Expect = 9.0
Identities = 16/57 (28%), Positives = 29/57 (50%)
Query: 228 LRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKL 284
L + L N+I+ +P + +L+ ++ L LD N L +G L +L L + N +
Sbjct: 50 LEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPI 106
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 69.3 bits (168), Expect = 6e-12
Identities = 49/134 (36%), Positives = 77/134 (57%), Gaps = 4/134 (2%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
LK L L L HN I +P +I + +L+ L ++N LES VA+ +LQK LR LD+S
Sbjct: 682 LKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVF--SLQK-LRCLDVSY 738
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLS 295
N I +P++ LQ L++L + N++ P ++ + I LR L+ +N + LP + LS
Sbjct: 739 NNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLS 798
Query: 296 -LEYLDLFGNTFEQ 308
L L+L GN ++
Sbjct: 799 QLTQLELKGNCLDR 812
Score = 67.8 bits (164), Expect = 2e-11
Identities = 49/153 (32%), Positives = 79/153 (51%), Gaps = 6/153 (3%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIG--DLIHLQELNLNDNHL 212
++ L+ C L R+ + L +L++LDL N+I+ + I L L L L N +
Sbjct: 636 NVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKI 695
Query: 213 ESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLI 272
+ ++ H K+L SL S NK+++LPV LQ+L+ L + N + P +IG L
Sbjct: 696 VTIPPSITHV---KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQ 752
Query: 273 NLRFLSAARNKLPFLPSE-FRNLSLEYLDLFGN 304
NL+ L NK+ LP + F+ + L L+L N
Sbjct: 753 NLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
Score = 59.3 bits (142), Expect = 6e-09
Identities = 40/116 (34%), Positives = 64/116 (55%), Gaps = 3/116 (2%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
+LE L S L + + + L+ LR LD+S+N+I +P IG L +LQ L++ N ++
Sbjct: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDI 766
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQ 270
L LR+L+L +N I +LP + QL +L L+L N L + P ++GQ
Sbjct: 767 LPKQLFKCI---KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ 819
Score = 56.2 bits (134), Expect = 5e-08
Identities = 46/201 (22%), Positives = 93/201 (46%), Gaps = 17/201 (8%)
Query: 96 ISSSLKGFLSAMRLAHRGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYS 155
+ +SLK ++ L + C ++ + + + + K+ + T ++ S
Sbjct: 627 VLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEII--------S 678
Query: 156 LEHLQTSYC------GLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLND 209
+HL+ C +V + + +K+L L S+N ++ LP + L L+ L+++
Sbjct: 679 FQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSY 738
Query: 210 NHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIG 269
N++ + + L ++L+ L ++ NK+ LP Q + +L+ L L N + P K+G
Sbjct: 739 NNISMIPIEI---GLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVG 795
Query: 270 QLINLRFLSAARNKLPFLPSE 290
QL L L N L LP++
Sbjct: 796 QLSQLTQLELKGNCLDRLPAQ 816
Score = 32.3 bits (72), Expect = 0.81
Identities = 41/168 (24%), Positives = 74/168 (44%), Gaps = 13/168 (7%)
Query: 191 KLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQE 250
K+PA I + +LQEL+L H + S L+ LR L + + +P L+
Sbjct: 504 KIPAKISQMTNLQELHL--CHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKN 561
Query: 251 LK------NLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGN 304
L+ NL ++N++I + +L +L+ L N L +PS +++ L +
Sbjct: 562 LRELYLIGNLNSENNKMIGLE-SLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIH 619
Query: 305 TFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLD 352
+ K+L + L+ + + E + RIP+ I Q+LD
Sbjct: 620 N-DGTKLLVLNSLKKMMNVAELELQNCELERIPHA--IFSLSNLQELD 664
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 69.3 bits (168), Expect = 6e-12
Identities = 49/134 (36%), Positives = 77/134 (57%), Gaps = 4/134 (2%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
LK L L L HN I +P +I + +L+ L ++N LES VA+ +LQK LR LD+S
Sbjct: 682 LKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVF--SLQK-LRCLDVSY 738
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLS 295
N I +P++ LQ L++L + N++ P ++ + I LR L+ +N + LP + LS
Sbjct: 739 NNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLS 798
Query: 296 -LEYLDLFGNTFEQ 308
L L+L GN ++
Sbjct: 799 QLTQLELKGNCLDR 812
Score = 67.8 bits (164), Expect = 2e-11
Identities = 49/153 (32%), Positives = 79/153 (51%), Gaps = 6/153 (3%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIG--DLIHLQELNLNDNHL 212
++ L+ C L R+ + L +L++LDL N+I+ + I L L L L N +
Sbjct: 636 NVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKI 695
Query: 213 ESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLI 272
+ ++ H K+L SL S NK+++LPV LQ+L+ L + N + P +IG L
Sbjct: 696 VTIPPSITHV---KNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQ 752
Query: 273 NLRFLSAARNKLPFLPSE-FRNLSLEYLDLFGN 304
NL+ L NK+ LP + F+ + L L+L N
Sbjct: 753 NLQHLHITGNKVDILPKQLFKCIKLRTLNLGQN 785
Score = 59.3 bits (142), Expect = 6e-09
Identities = 40/116 (34%), Positives = 64/116 (55%), Gaps = 3/116 (2%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
+LE L S L + + + L+ LR LD+S+N+I +P IG L +LQ L++ N ++
Sbjct: 707 NLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDI 766
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQ 270
L LR+L+L +N I +LP + QL +L L+L N L + P ++GQ
Sbjct: 767 LPKQLFKCI---KLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQ 819
Score = 56.2 bits (134), Expect = 5e-08
Identities = 46/201 (22%), Positives = 93/201 (46%), Gaps = 17/201 (8%)
Query: 96 ISSSLKGFLSAMRLAHRGCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYS 155
+ +SLK ++ L + C ++ + + + + K+ + T ++ S
Sbjct: 627 VLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEII--------S 678
Query: 156 LEHLQTSYC------GLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLND 209
+HL+ C +V + + +K+L L S+N ++ LP + L L+ L+++
Sbjct: 679 FQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSY 738
Query: 210 NHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIG 269
N++ + + L ++L+ L ++ NK+ LP Q + +L+ L L N + P K+G
Sbjct: 739 NNISMIPIEI---GLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVG 795
Query: 270 QLINLRFLSAARNKLPFLPSE 290
QL L L N L LP++
Sbjct: 796 QLSQLTQLELKGNCLDRLPAQ 816
Score = 32.3 bits (72), Expect = 0.81
Identities = 41/168 (24%), Positives = 74/168 (44%), Gaps = 13/168 (7%)
Query: 191 KLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQE 250
K+PA I + +LQEL+L H + S L+ LR L + + +P L+
Sbjct: 504 KIPAKISQMTNLQELHL--CHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKN 561
Query: 251 LK------NLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGN 304
L+ NL ++N++I + +L +L+ L N L +PS +++ L +
Sbjct: 562 LRELYLIGNLNSENNKMIGLE-SLRELRHLKILHVKSN-LTKVPSNITDVAPHLTKLVIH 619
Query: 305 TFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLD 352
+ K+L + L+ + + E + RIP+ I Q+LD
Sbjct: 620 N-DGTKLLVLNSLKKMMNVAELELQNCELERIPHA--IFSLSNLQELD 664
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 69.3 bits (168), Expect = 6e-12
Identities = 60/174 (34%), Positives = 83/174 (47%), Gaps = 9/174 (5%)
Query: 156 LEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESF 215
L HL S+ L + +L ++ L L LSHN + +LP +G L L L + N L++
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 216 SVAL-CHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
AL STLQ+ LDLS+N + LP + L L L L N L P + L +L
Sbjct: 187 PPALGALSTLQR----LDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSL 242
Query: 275 RFLSAARNKLPFLPSEFRNLS-LEYLDLFGNTFEQPKVLPVIKLQAPLTLLESS 327
R L N L +P++ L L LDL N Q + LP L AP L+ +
Sbjct: 243 RLLVLHSNLLASVPADLARLPLLTRLDLRDN---QLRDLPPELLDAPFVRLQGN 293
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/171 (29%), Positives = 73/171 (42%), Gaps = 16/171 (9%)
Query: 171 MRMLCLKSLRKLDLS----HNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQK 226
+R L LK ++ D + LPA + L HL L+L+ N LE+ + +
Sbjct: 92 LRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQ---MR 148
Query: 227 SLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPF 286
L +L LS N + LP L L L + N L P +G L L+ L ++N L
Sbjct: 149 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 208
Query: 287 LPSEFRNL-SLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRI 336
LP E L SL L+L N + L A L L S +LH+ +
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQ--------SLPASLAGLRSLRLLVLHSNL 251
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 69.3 bits (168), Expect = 6e-12
Identities = 60/174 (34%), Positives = 83/174 (47%), Gaps = 9/174 (5%)
Query: 156 LEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESF 215
L HL S+ L + +L ++ L L LSHN + +LP +G L L L + N L++
Sbjct: 127 LAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTL 186
Query: 216 SVAL-CHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
AL STLQ+ LDLS+N + LP + L L L L N L P + L +L
Sbjct: 187 PPALGALSTLQR----LDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSL 242
Query: 275 RFLSAARNKLPFLPSEFRNLS-LEYLDLFGNTFEQPKVLPVIKLQAPLTLLESS 327
R L N L +P++ L L LDL N Q + LP L AP L+ +
Sbjct: 243 RLLVLHSNLLASVPADLARLPLLTRLDLRDN---QLRDLPPELLDAPFVRLQGN 293
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/171 (29%), Positives = 73/171 (42%), Gaps = 16/171 (9%)
Query: 171 MRMLCLKSLRKLDLS----HNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQK 226
+R L LK ++ D + LPA + L HL L+L+ N LE+ + +
Sbjct: 92 LRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQ---MR 148
Query: 227 SLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPF 286
L +L LS N + LP L L L + N L P +G L L+ L ++N L
Sbjct: 149 GLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDT 208
Query: 287 LPSEFRNL-SLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRI 336
LP E L SL L+L N + L A L L S +LH+ +
Sbjct: 209 LPPEIGGLGSLLELNLASNRLQ--------SLPASLAGLRSLRLLVLHSNL 251
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 69.3 bits (168), Expect = 6e-12
Identities = 49/129 (37%), Positives = 65/129 (50%), Gaps = 4/129 (3%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
L SL L L HN ++ L +G+L L LNL+ N L +C Q LR L +S
Sbjct: 90 LVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYIC----QLPLRVLIVSN 145
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLS 295
NK+ ALP L L+ L + NEL P ++ L +LR L+ RN+L LP E +L
Sbjct: 146 NKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP 205
Query: 296 LEYLDLFGN 304
L LD N
Sbjct: 206 LVRLDFSCN 214
Score = 57.4 bits (137), Expect = 2e-08
Identities = 46/143 (32%), Positives = 69/143 (48%), Gaps = 26/143 (18%)
Query: 162 SYCGLVRVDMRML----CLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSV 217
+Y L R + +L C LR L +S+N + LP IG L L++L+++ N L+S
Sbjct: 117 TYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPS 176
Query: 218 ALCH--------------STLQKSLRS-----LDLSKNKIKALPVQFCQLQELKNLKLDD 258
LC STL + L LD S N++ +PV FC+L+ L+ + LD
Sbjct: 177 ELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDS 236
Query: 259 NELIQFP---CKIGQLINLRFLS 278
N L P C G+L ++LS
Sbjct: 237 NPLQSPPAQVCLKGKLHIFKYLS 259
Score = 48.1 bits (113), Expect = 1e-05
Identities = 32/100 (32%), Positives = 46/100 (46%)
Query: 205 LNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQF 264
LNL++ L+ F S + DLS+N+ +P CQL L+ L L N L
Sbjct: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
Query: 265 PCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLFGN 304
+G L L +L+ +RN+L LP L L L + N
Sbjct: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNN 146
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 68.2 bits (165), Expect = 1e-11
Identities = 59/192 (30%), Positives = 86/192 (44%), Gaps = 25/192 (13%)
Query: 148 LSKNFPYSLEH---LQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQE 204
L N ++L H L S+ L V + LK+L L+ +N I++LP I L L+
Sbjct: 31 LDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKH 90
Query: 205 LNLNDNHLESFS-----------VALCHSTLQKS-----------LRSLDLSKNKIKALP 242
LNL N L + + L ++ L ++ LR+L LS N + LP
Sbjct: 91 LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILP 150
Query: 243 VQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLDLF 302
+L +L+ L L DN+LI P +IG+L L+ L N+L LP E NL L
Sbjct: 151 PDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQV 210
Query: 303 GNTFEQPKVLPV 314
P V P+
Sbjct: 211 FKAENNPWVTPI 222
>gi|33285015 leucine rich repeat containing 28 [Homo sapiens]
Length = 367
Score = 68.2 bits (165), Expect = 1e-11
Identities = 44/130 (33%), Positives = 74/130 (56%), Gaps = 4/130 (3%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
L +L +L L N+I +P IG L+ LQ L+L+DN LE + ++LR L L+
Sbjct: 64 LPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALE---IVCPEIGRLRALRHLRLAN 120
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL- 294
N+++ LP + L+EL+ L + N L+ P ++ ++L++L+ RN+L ++P L
Sbjct: 121 NQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQYLTVDRNRLWYVPRHLCQLP 180
Query: 295 SLEYLDLFGN 304
SL L + GN
Sbjct: 181 SLNELSMAGN 190
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 67.4 bits (163), Expect = 2e-11
Identities = 49/139 (35%), Positives = 69/139 (49%), Gaps = 1/139 (0%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
L+ L+ L+L N + LP G L L+ L+L N+L S+ L +LR+L LS
Sbjct: 32 LQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLT-TLRALYLSD 90
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLS 295
N + LP +L +L+ L L DN+LI P +IG+L L+ L N+L LP E NL
Sbjct: 91 NDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 150
Query: 296 LEYLDLFGNTFEQPKVLPV 314
L P V P+
Sbjct: 151 LTGQKQVFKAENNPWVTPI 169
Score = 43.5 bits (101), Expect = 4e-04
Identities = 37/98 (37%), Positives = 46/98 (46%), Gaps = 5/98 (5%)
Query: 226 KSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLP 285
K+L L+ N+I+ LP Q LQ+LK+L L N L P G L L L N L
Sbjct: 10 KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLS 69
Query: 286 --FLPSEFRNL-SLEYLDLFGNTFE--QPKVLPVIKLQ 318
LP F L +L L L N FE P + + KLQ
Sbjct: 70 ENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQ 107
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 67.4 bits (163), Expect = 2e-11
Identities = 47/142 (33%), Positives = 81/142 (57%), Gaps = 4/142 (2%)
Query: 155 SLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLES 214
+L+ L S+ L + + L++L+ L L HN + + L +L++L+L++NHL +
Sbjct: 129 NLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTT 188
Query: 215 FSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINL 274
V S+L +R L+LS N++K+LP + +++ LK+L + N L P ++ + +L
Sbjct: 189 --VPASFSSLSSLVR-LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESL 245
Query: 275 RFLSAARNKLPFLPSEFRNLSL 296
L RNKL FLP EF + SL
Sbjct: 246 ELLYLRRNKLRFLP-EFPSCSL 266
Score = 63.9 bits (154), Expect = 3e-10
Identities = 44/139 (31%), Positives = 74/139 (53%), Gaps = 6/139 (4%)
Query: 170 DMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLR 229
D+R+L +L LD+ N + LP+ I +L +LQ+LN++ N L+ + T ++L+
Sbjct: 100 DLRLL--PALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEI---TNLRNLK 154
Query: 230 SLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPS 289
L L N++ + F QL L++L L +N L P L +L L+ + N+L LP+
Sbjct: 155 CLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPA 214
Query: 290 EFRNLS-LEYLDLFGNTFE 307
E + L++LD N E
Sbjct: 215 EINRMKRLKHLDCNSNLLE 233
Score = 58.5 bits (140), Expect = 1e-08
Identities = 45/127 (35%), Positives = 67/127 (52%), Gaps = 4/127 (3%)
Query: 179 LRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKI 238
L KL +S+N ++ L + L L L+++DN L S A+ ++L+ L++S NK+
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIREL---ENLQKLNVSHNKL 140
Query: 239 KALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNL-SLE 297
K LP + L+ LK L L NEL QL NL L + N L +P+ F +L SL
Sbjct: 141 KILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLV 200
Query: 298 YLDLFGN 304
L+L N
Sbjct: 201 RLNLSSN 207
Score = 54.3 bits (129), Expect = 2e-07
Identities = 33/117 (28%), Positives = 62/117 (52%), Gaps = 4/117 (3%)
Query: 162 SYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCH 221
S+ L + + + L+ L LDL +N + LP + L+ LQ +NL+ N + L
Sbjct: 457 SFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYR 516
Query: 222 STLQKSLRSLDLSKNKIKAL-PVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFL 277
+L ++ +S N++ ++ P + ++ L L L +N+L+Q P ++G +NLR L
Sbjct: 517 IF---TLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTL 570
Score = 53.9 bits (128), Expect = 3e-07
Identities = 41/141 (29%), Positives = 69/141 (48%), Gaps = 4/141 (2%)
Query: 144 KDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQ 203
K P N L+HL + L + + ++SL L L N ++ LP + L+
Sbjct: 210 KSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSL-LK 268
Query: 204 ELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQ 263
EL++ +N +E H S+ LDL NK+K++P + L+ L+ L L +N++
Sbjct: 269 ELHVGENQIEMLEAE--HLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISS 326
Query: 264 FPCKIGQLINLRFLSAARNKL 284
P +G L +L+FL+ N L
Sbjct: 327 LPYSLGNL-HLKFLALEGNPL 346
Score = 47.0 bits (110), Expect = 3e-05
Identities = 27/70 (38%), Positives = 37/70 (52%)
Query: 225 QKSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKL 284
Q L L +S NK+++L L L L + DN+L P I +L NL+ L+ + NKL
Sbjct: 81 QTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKL 140
Query: 285 PFLPSEFRNL 294
LP E NL
Sbjct: 141 KILPEEITNL 150
Score = 43.9 bits (102), Expect = 3e-04
Identities = 33/131 (25%), Positives = 64/131 (48%), Gaps = 6/131 (4%)
Query: 178 SLRKLDLSHNHIKKLPATIGDLIH---LQELNLNDNHLESFSVALCHSTLQKSLRSLDLS 234
+L+ LD S +P + D + + +N + N L + L++ + +DLS
Sbjct: 400 TLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVE--LKEMVSDVDLS 457
Query: 235 KNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSE-FRN 293
NK+ + ++ C LQ+L L L +N L P ++ L+ L+ ++ + N+ LP +R
Sbjct: 458 FNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRI 517
Query: 294 LSLEYLDLFGN 304
+LE + + N
Sbjct: 518 FTLETILISNN 528
Score = 40.0 bits (92), Expect = 0.004
Identities = 48/182 (26%), Positives = 76/182 (41%), Gaps = 36/182 (19%)
Query: 182 LDLSHNHIKKLPATIGDLIHL-QELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKA 240
++ S N + ++P + +L + +++L+ N L S+ LC LQK L LDL N + +
Sbjct: 430 INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELC--VLQK-LTFLDLRNNFLNS 486
Query: 241 LPVQFCQLQELKNLKLDDNELIQF------------------------PCKIGQLINLRF 276
LP + L L+ + L N P K+ + NL
Sbjct: 487 LPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTT 546
Query: 277 LSAARNKLPFLPSEFRN-LSLEYLDLFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNR 335
L N L +P E N ++L L L GN F P+ I ++ +LE L +R
Sbjct: 547 LDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRA--AILMKGTAAILE-----YLRDR 599
Query: 336 IP 337
IP
Sbjct: 600 IP 601
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 67.4 bits (163), Expect = 2e-11
Identities = 60/187 (32%), Positives = 82/187 (43%), Gaps = 17/187 (9%)
Query: 118 TPVSTLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLK 177
T V +L+ K EF +T LS+N L + C V
Sbjct: 59 TGVLSLSGRKLREFPRGAANHDLTDTTRADLSRN---RLSEIPIEACHFV---------- 105
Query: 178 SLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNK 237
SL L+L N I+ +P I +L L LN++ N L + V LC+ L + L S NK
Sbjct: 106 SLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLPL----KVLIASNNK 161
Query: 238 IKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLE 297
+ +LP + L+ L L + NE+ P +IG L LR L+ RN L LP E L L
Sbjct: 162 LVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLI 221
Query: 298 YLDLFGN 304
LD N
Sbjct: 222 RLDFSCN 228
Score = 59.3 bits (142), Expect = 6e-09
Identities = 42/117 (35%), Positives = 66/117 (56%), Gaps = 8/117 (6%)
Query: 176 LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSK 235
L+ L +LD+S N I+ +P+ IG+L L++LN+ NHL V L + L LD S
Sbjct: 172 LRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHL----VHLPEELAELPLIRLDFSC 227
Query: 236 NKIKALPVQFCQLQELKNLKLDDNELIQFPCKI---GQLINLRFLSAARNKL-PFLP 288
NKI +PV + L+ L+ + LD+N L P +I G++ ++L+ K+ P LP
Sbjct: 228 NKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLP 284
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 67.0 bits (162), Expect = 3e-11
Identities = 55/198 (27%), Positives = 95/198 (47%), Gaps = 4/198 (2%)
Query: 113 GCNVDTPVSTLTPVKTSEFENFKTKMVITSKKDYP-LSKNFPYSLEHLQTSYCGLVRVDM 171
GC + +ST+ + +N +T + +S P + + SL+ L G V +
Sbjct: 519 GCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL 578
Query: 172 RMLC-LKSLRKLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRS 230
L + +L+ L+L ++++P +I L +L EL+L +N+L++ + LQ +L
Sbjct: 579 NNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQ-NLSC 637
Query: 231 LDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSE 290
L L N I +P Q L L+ L LD N + P ++ L +L + N L F+P E
Sbjct: 638 LKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEE 697
Query: 291 FRNLS-LEYLDLFGNTFE 307
+ LS L+Y + N E
Sbjct: 698 IQYLSNLQYFAVTNNNIE 715
Score = 57.0 bits (136), Expect = 3e-08
Identities = 65/244 (26%), Positives = 109/244 (44%), Gaps = 27/244 (11%)
Query: 62 LRENIEQFFTKFVDEGKAT------VRLKEPPVDICL--SKAISSSLKGF-----LSAMR 108
L EN++ KF + GK LKE + C+ + + L+GF L +
Sbjct: 485 LEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLY 544
Query: 109 LAHRGCNVDTPVSTLTP-VKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLV 167
L + V+ L P ++ +N +K+V+ + L K +L+ L+ C L
Sbjct: 545 LKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNN----LKKMV--NLKSLELISCDLE 598
Query: 168 RVDMRMLCLKSLRKLDLSHNHIKKLPATIGDLIHLQEL-NLNDNHLESFSVALCHSTLQ- 225
R+ + L +L +LDL N++K T+ ++I Q L NL+ L ++A + +
Sbjct: 599 RIPHSIFSLNNLHELDLRENNLK----TVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA 654
Query: 226 -KSLRSLDLSKNKIKALPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKL 284
+L L L N I+ LP+Q +L L L N L P +I L NL++ + N +
Sbjct: 655 LSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNI 714
Query: 285 PFLP 288
LP
Sbjct: 715 EMLP 718
Score = 31.6 bits (70), Expect = 1.4
Identities = 26/108 (24%), Positives = 52/108 (48%), Gaps = 12/108 (11%)
Query: 202 LQELNLNDNHLESFSVALCHSTLQKSLRS-LDLSKNKIKALPVQFCQLQELKNLKLDDNE 260
L+++NLN+ ++V S L K+ + ++L + LP +L E++ L L+
Sbjct: 396 LKQINLNNE----WTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIP 451
Query: 261 LIQFPCKIGQLINLRFLSAARNK-------LPFLPSEFRNLSLEYLDL 301
++ P + QL+NL+ L + L FL + L L++ ++
Sbjct: 452 EVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEM 499
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,082,886
Number of Sequences: 37866
Number of extensions: 640518
Number of successful extensions: 2561
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 1524
Number of HSP's gapped (non-prelim): 676
length of query: 414
length of database: 18,247,518
effective HSP length: 105
effective length of query: 309
effective length of database: 14,271,588
effective search space: 4409920692
effective search space used: 4409920692
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.