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Search of human proteins with 45269137
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45269137 mitofusin 1 [Homo sapiens]
(741 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45269137 mitofusin 1 [Homo sapiens] 1466 0.0
gi|189083768 mitofusin 2 [Homo sapiens] 956 0.0
gi|7662004 mitofusin 2 [Homo sapiens] 956 0.0
gi|222136619 myxovirus resistance protein 1 [Homo sapiens] 44 7e-04
gi|222136617 myxovirus resistance protein 1 [Homo sapiens] 44 7e-04
gi|4759198 homer 1 [Homo sapiens] 40 0.006
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 39 0.023
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 37 0.087
gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens] 36 0.11
gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens] 36 0.11
gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens] 36 0.11
gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens] 36 0.11
gi|153945715 myosin VC [Homo sapiens] 36 0.11
gi|33188443 microfilament and actin filament cross-linker protei... 35 0.19
gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo sa... 35 0.19
gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo sa... 35 0.19
gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo sa... 35 0.19
gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo sa... 35 0.19
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ... 35 0.19
gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens] 35 0.33
gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens] 35 0.33
gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens] 35 0.33
gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens] 35 0.33
gi|197116359 inositol polyphosphate-4-phosphatase, type 1 isofor... 34 0.43
gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform ... 34 0.43
gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform ... 34 0.43
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 34 0.56
gi|4505047 lumican precursor [Homo sapiens] 34 0.56
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 34 0.56
gi|33946313 ninein isoform 4 [Homo sapiens] 34 0.56
>gi|45269137 mitofusin 1 [Homo sapiens]
Length = 741
Score = 1466 bits (3796), Expect = 0.0
Identities = 741/741 (100%), Positives = 741/741 (100%)
Query: 1 MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGY 60
MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGY
Sbjct: 1 MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGY 60
Query: 61 KDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDG 120
KDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDG
Sbjct: 61 KDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDG 120
Query: 121 DKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSP 180
DKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSP
Sbjct: 121 DKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSP 180
Query: 181 GTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD 240
GTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD
Sbjct: 181 GTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD 240
Query: 241 ASASEPEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMP 300
ASASEPEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMP
Sbjct: 241 ASASEPEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMP 300
Query: 301 ESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNL 360
ESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNL
Sbjct: 301 ESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNL 360
Query: 361 AAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRL 420
AAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRL
Sbjct: 361 AAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRL 420
Query: 421 SVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENL 480
SVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENL
Sbjct: 421 SVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENL 480
Query: 481 KPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRN 540
KPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRN
Sbjct: 481 KPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRN 540
Query: 541 AQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLVTGLASVTSRTSMGII 600
AQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLVTGLASVTSRTSMGII
Sbjct: 541 AQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLVTGLASVTSRTSMGII 600
Query: 601 IVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSS 660
IVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSS
Sbjct: 601 IVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSS 660
Query: 661 TSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAV 720
TSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAV
Sbjct: 661 TSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAV 720
Query: 721 QLENELENFTKQFLPSSNEES 741
QLENELENFTKQFLPSSNEES
Sbjct: 721 QLENELENFTKQFLPSSNEES 741
>gi|189083768 mitofusin 2 [Homo sapiens]
Length = 757
Score = 956 bits (2470), Expect = 0.0
Identities = 466/733 (63%), Positives = 598/733 (81%), Gaps = 4/733 (0%)
Query: 6 SPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGYKDKLS 65
SPLKHFV AKK I IF+QL ++ E + F+E TY+N ELD + TE+ +++++GY K+
Sbjct: 27 SPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEEQVLDVKGYLSKVR 86
Query: 66 IIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYL 125
I EVL+RRHMKVAFFGRTS+GKS+VINAMLWDKVLPSGIGH TNCFL VEGTDG +A+L
Sbjct: 87 GISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVEGTDGHEAFL 146
Query: 126 MTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVT 185
+TEGS+EK+S KTVNQLAHALH DK L AG LV V WP +KC LL+DDLVL+DSPG DVT
Sbjct: 147 LTEGSEEKRSAKTVNQLAHALHQDKQLHAGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVT 206
Query: 186 TELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASE 245
TELDSWIDKFCLDADVFVLVANSESTLM TEKHFFHKV+ERLS+PNIFILNNRWDASASE
Sbjct: 207 TELDSWIDKFCLDADVFVLVANSESTLMQTEKHFFHKVSERLSRPNIFILNNRWDASASE 266
Query: 246 PEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVA 305
PEYME+VRRQHMERC FLV+EL VV+ +A +RIFFVSAKEVL+AR QKAQGMPE G A
Sbjct: 267 PEYMEEVRRQHMERCTSFLVDELGVVDRSQAGDRIFFVSAKEVLNARIQKAQGMPEGGGA 326
Query: 306 LAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDK 365
LAEGF R+ EFQNFE+ FEECISQSAVKTKFEQHT+RAKQI V+ IMDS+++AA ++
Sbjct: 327 LAEGFQVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHMAAREQ 386
Query: 366 RHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVD 425
+ Y E RE++ DRL FI Q+ LL D K +IK++TEEV +VS AM +EI RLSVLVD
Sbjct: 387 QVYCEEMREERQDRLKFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVD 446
Query: 426 EFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENLKPLLP 485
++ +FHP+P VLK+YK+EL++HIE+G+GRN++DRC+ + + QQ++I+ LKPLLP
Sbjct: 447 DYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAITNSLQTMQQDMIDGLKPLLP 506
Query: 486 AGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRNAQRVL 545
++ ++ L+P + F L+Y+LN KLC+DFQEDI F FSLGW+ LV+RFLGP+N++R L
Sbjct: 507 VSVRSQIDMLVPRQCFSLNYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRAL 566
Query: 546 LGLSEPIFQLPRSLASTPTAPTTPATPDNA-SQEELMITLVTGLASVTSRTSMGIIIVGG 604
+G ++ Q+ R + TP P+ P P + +QEE M+++VTGLAS+TSRTSMGI++VGG
Sbjct: 567 MGYND---QVQRPIPLTPANPSMPPLPQGSLTQEEFMVSMVTGLASLTSRTSMGILVVGG 623
Query: 605 VIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSAN 664
V+WK +GW+L+++S +YG LY+YERL+WTT AKERAFK+QFV +A+EKL++++S T +N
Sbjct: 624 VVWKAVGWRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEHASEKLQLVISYTGSN 683
Query: 665 CSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLEN 724
CSHQV+Q+++ TFA LCQQVD+T++ LE+EIA + K+I+ L+ +Q+ +KLLRNKA L++
Sbjct: 684 CSHQVQQELSGTFAHLCQQVDVTRENLEQEIAAMNKKIEVLDSLQSKAKLLRNKAGWLDS 743
Query: 725 ELENFTKQFLPSS 737
EL FT Q+L S
Sbjct: 744 ELNMFTHQYLQPS 756
>gi|7662004 mitofusin 2 [Homo sapiens]
Length = 757
Score = 956 bits (2470), Expect = 0.0
Identities = 466/733 (63%), Positives = 598/733 (81%), Gaps = 4/733 (0%)
Query: 6 SPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGYKDKLS 65
SPLKHFV AKK I IF+QL ++ E + F+E TY+N ELD + TE+ +++++GY K+
Sbjct: 27 SPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEEQVLDVKGYLSKVR 86
Query: 66 IIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYL 125
I EVL+RRHMKVAFFGRTS+GKS+VINAMLWDKVLPSGIGH TNCFL VEGTDG +A+L
Sbjct: 87 GISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVEGTDGHEAFL 146
Query: 126 MTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVT 185
+TEGS+EK+S KTVNQLAHALH DK L AG LV V WP +KC LL+DDLVL+DSPG DVT
Sbjct: 147 LTEGSEEKRSAKTVNQLAHALHQDKQLHAGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVT 206
Query: 186 TELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASE 245
TELDSWIDKFCLDADVFVLVANSESTLM TEKHFFHKV+ERLS+PNIFILNNRWDASASE
Sbjct: 207 TELDSWIDKFCLDADVFVLVANSESTLMQTEKHFFHKVSERLSRPNIFILNNRWDASASE 266
Query: 246 PEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVA 305
PEYME+VRRQHMERC FLV+EL VV+ +A +RIFFVSAKEVL+AR QKAQGMPE G A
Sbjct: 267 PEYMEEVRRQHMERCTSFLVDELGVVDRSQAGDRIFFVSAKEVLNARIQKAQGMPEGGGA 326
Query: 306 LAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDK 365
LAEGF R+ EFQNFE+ FEECISQSAVKTKFEQHT+RAKQI V+ IMDS+++AA ++
Sbjct: 327 LAEGFQVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHMAAREQ 386
Query: 366 RHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVD 425
+ Y E RE++ DRL FI Q+ LL D K +IK++TEEV +VS AM +EI RLSVLVD
Sbjct: 387 QVYCEEMREERQDRLKFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVD 446
Query: 426 EFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENLKPLLP 485
++ +FHP+P VLK+YK+EL++HIE+G+GRN++DRC+ + + QQ++I+ LKPLLP
Sbjct: 447 DYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAITNSLQTMQQDMIDGLKPLLP 506
Query: 486 AGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRNAQRVL 545
++ ++ L+P + F L+Y+LN KLC+DFQEDI F FSLGW+ LV+RFLGP+N++R L
Sbjct: 507 VSVRSQIDMLVPRQCFSLNYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRAL 566
Query: 546 LGLSEPIFQLPRSLASTPTAPTTPATPDNA-SQEELMITLVTGLASVTSRTSMGIIIVGG 604
+G ++ Q+ R + TP P+ P P + +QEE M+++VTGLAS+TSRTSMGI++VGG
Sbjct: 567 MGYND---QVQRPIPLTPANPSMPPLPQGSLTQEEFMVSMVTGLASLTSRTSMGILVVGG 623
Query: 605 VIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSAN 664
V+WK +GW+L+++S +YG LY+YERL+WTT AKERAFK+QFV +A+EKL++++S T +N
Sbjct: 624 VVWKAVGWRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEHASEKLQLVISYTGSN 683
Query: 665 CSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLEN 724
CSHQV+Q+++ TFA LCQQVD+T++ LE+EIA + K+I+ L+ +Q+ +KLLRNKA L++
Sbjct: 684 CSHQVQQELSGTFAHLCQQVDVTRENLEQEIAAMNKKIEVLDSLQSKAKLLRNKAGWLDS 743
Query: 725 ELENFTKQFLPSS 737
EL FT Q+L S
Sbjct: 744 ELNMFTHQYLQPS 756
>gi|222136619 myxovirus resistance protein 1 [Homo sapiens]
Length = 662
Score = 43.5 bits (101), Expect = 7e-04
Identities = 103/491 (20%), Positives = 186/491 (37%), Gaps = 70/491 (14%)
Query: 62 DKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEG---T 118
D L +G +A G SSGKSSV+ A L LP G G +T C L ++
Sbjct: 57 DSLRALGVEQDLALPAIAVIGDQSSGKSSVLEA-LSGVALPRGSGIVTRCPLVLKLKKLV 115
Query: 119 DGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALL-RD--DLV 175
+ DK D + + +++ ++ ++ AG + + + RD DL
Sbjct: 116 NEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLT 175
Query: 176 LVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFIL 235
L+D PG V V N + + K K +R ++ ++
Sbjct: 176 LIDLPGI------------------TRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVV 217
Query: 236 NNRWDASASEPEYMEDVRRQHMERCLHFLVE--------ELKVVNALEAQNRIFFVSAKE 287
+ D + +E M +R + L + E KVV+ + +N +F + K+
Sbjct: 218 PSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVV--RNLVFHL--KK 273
Query: 288 VLSARKQKAQGMPESGVALAEGFHARLQEFQN---FEQIFEE---CISQSAVKTKFEQHT 341
K + Q + ++L+E F+N F + EE + A K E T
Sbjct: 274 GYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELIT 333
Query: 342 IRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKI--K 399
K + I ++ E+ + Y V+ ED+ +++ F+ +++N D+ + +
Sbjct: 334 HICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE 393
Query: 400 EVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLAD 459
E E ++ + E + S +++ E H KI ++ K GR L
Sbjct: 394 ETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGH------KILSRKIQKFENQYRGRELPG 447
Query: 460 RCTDEVNALVLQTQQEIIENLKPLLPAGIQDKLHTL----------IPCKKFDLSYNLNY 509
+++ Q + +E PA D LHT+ + K F+ +NL
Sbjct: 448 FVNYRTFETIVKQQIKALEE-----PA--VDMLHTVTDMVRLAFTDVSIKNFEEFFNL-- 498
Query: 510 HKLCSDFQEDI 520
H+ EDI
Sbjct: 499 HRTAKSKIEDI 509
>gi|222136617 myxovirus resistance protein 1 [Homo sapiens]
Length = 662
Score = 43.5 bits (101), Expect = 7e-04
Identities = 103/491 (20%), Positives = 186/491 (37%), Gaps = 70/491 (14%)
Query: 62 DKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEG---T 118
D L +G +A G SSGKSSV+ A L LP G G +T C L ++
Sbjct: 57 DSLRALGVEQDLALPAIAVIGDQSSGKSSVLEA-LSGVALPRGSGIVTRCPLVLKLKKLV 115
Query: 119 DGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALL-RD--DLV 175
+ DK D + + +++ ++ ++ AG + + + RD DL
Sbjct: 116 NEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLT 175
Query: 176 LVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFIL 235
L+D PG V V N + + K K +R ++ ++
Sbjct: 176 LIDLPGI------------------TRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVV 217
Query: 236 NNRWDASASEPEYMEDVRRQHMERCLHFLVE--------ELKVVNALEAQNRIFFVSAKE 287
+ D + +E M +R + L + E KVV+ + +N +F + K+
Sbjct: 218 PSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVV--RNLVFHL--KK 273
Query: 288 VLSARKQKAQGMPESGVALAEGFHARLQEFQN---FEQIFEE---CISQSAVKTKFEQHT 341
K + Q + ++L+E F+N F + EE + A K E T
Sbjct: 274 GYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELIT 333
Query: 342 IRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKI--K 399
K + I ++ E+ + Y V+ ED+ +++ F+ +++N D+ + +
Sbjct: 334 HICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGE 393
Query: 400 EVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLAD 459
E E ++ + E + S +++ E H KI ++ K GR L
Sbjct: 394 ETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGH------KILSRKIQKFENQYRGRELPG 447
Query: 460 RCTDEVNALVLQTQQEIIENLKPLLPAGIQDKLHTL----------IPCKKFDLSYNLNY 509
+++ Q + +E PA D LHT+ + K F+ +NL
Sbjct: 448 FVNYRTFETIVKQQIKALEE-----PA--VDMLHTVTDMVRLAFTDVSIKNFEEFFNL-- 498
Query: 510 HKLCSDFQEDI 520
H+ EDI
Sbjct: 499 HRTAKSKIEDI 509
>gi|4759198 homer 1 [Homo sapiens]
Length = 354
Score = 40.4 bits (93), Expect = 0.006
Identities = 32/114 (28%), Positives = 48/114 (42%), Gaps = 10/114 (8%)
Query: 637 AKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQIATTFARL---CQQVDITQKQLEE 693
A + +KQQ Y E R+ T C + T L Q+++ T K EE
Sbjct: 206 ANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEE 265
Query: 694 EIARLPKEIDQLEKIQNNSKLLRNKAVQ-------LENELENFTKQFLPSSNEE 740
EI RL +EID ++Q L K + LE +L + ++ S NE+
Sbjct: 266 EIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQ 319
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 38.5 bits (88), Expect = 0.023
Identities = 69/338 (20%), Positives = 139/338 (41%), Gaps = 62/338 (18%)
Query: 204 LVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHF 263
L+ N ++ N +K ++NE L K N + + + +E++ RQ+ E L
Sbjct: 1541 LLQNIKAEKENNDK--IQRLNEELEKSN--------ECAEMLKQKVEELTRQNNETKLMM 1590
Query: 264 LVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARL---QEFQNF 320
+ + N + + I ++ A K +A G + + E H + Q+FQ
Sbjct: 1591 QRIQAESENIVLEKQTI-----QQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRK 1645
Query: 321 EQIFEECISQSA-----VKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKR--HYSVEER 373
+ EE +++S K K +Q I + V+N+ +N + E+KR V+ +
Sbjct: 1646 IKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705
Query: 374 EDQI----DRLDFIRNQMNLLTLDVKK-------------KIKEVTEEVANKVSCAMTDE 416
+ Q+ +RL ++++++L T++ + K K+ EE K+ M +
Sbjct: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESK 1765
Query: 417 I--------CRLS-VLVDEFCSEFHPNPDVLKIYKSELNKHIE---------DGMGRNLA 458
+ RL V + + S N + + EL + ++ M N
Sbjct: 1766 VITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHY 1825
Query: 459 DRCTDEVNALVLQTQQEIIENLKPLLPAGIQDKLHTLI 496
+C + L+ Q ++ +ENLK + I++ H L+
Sbjct: 1826 QKCQKLEDELIAQKRE--VENLKQKMDQQIKEHEHQLV 1861
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 36.6 bits (83), Expect = 0.087
Identities = 15/51 (29%), Positives = 31/51 (60%)
Query: 677 FARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLENELE 727
+ R +Q + ++ +E E++ L +++ L+K+ NS+L K QL+ +LE
Sbjct: 498 YQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLE 548
>gi|224831248 optic atrophy 1 isoform 5 [Homo sapiens]
Length = 978
Score = 36.2 bits (82), Expect = 0.11
Identities = 52/201 (25%), Positives = 87/201 (43%), Gaps = 31/201 (15%)
Query: 9 KHF--VLAKKAITAIFDQLLEFVTEGSHFVEATYK-NPELDRIATEDDLVEMQGYKDKLS 65
KHF V K+ I + ++LL + +E K N EL ++ + D + K K S
Sbjct: 222 KHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKS 281
Query: 66 II---GEVL-----------SRRHM-KVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-IT 109
+I EVL ++ H+ +V G S+GK+SV+ + ++ P G G +T
Sbjct: 282 LIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMT 341
Query: 110 NCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALH-----MDKDLKAGCLVRVFWPK 164
+ V ++G + + S + + LA H M K++K GC V P+
Sbjct: 342 RSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS---PE 398
Query: 165 AKCALLR----DDLVLVDSPG 181
++ +VLVD PG
Sbjct: 399 TISLNVKGPGLQRMVLVDLPG 419
>gi|18860833 optic atrophy 1 isoform 3 [Homo sapiens]
Length = 942
Score = 36.2 bits (82), Expect = 0.11
Identities = 52/201 (25%), Positives = 87/201 (43%), Gaps = 31/201 (15%)
Query: 9 KHF--VLAKKAITAIFDQLLEFVTEGSHFVEATYK-NPELDRIATEDDLVEMQGYKDKLS 65
KHF V K+ I + ++LL + +E K N EL ++ + D + K K S
Sbjct: 186 KHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKS 245
Query: 66 II---GEVL-----------SRRHM-KVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-IT 109
+I EVL ++ H+ +V G S+GK+SV+ + ++ P G G +T
Sbjct: 246 LIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMT 305
Query: 110 NCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALH-----MDKDLKAGCLVRVFWPK 164
+ V ++G + + S + + LA H M K++K GC V P+
Sbjct: 306 RSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS---PE 362
Query: 165 AKCALLR----DDLVLVDSPG 181
++ +VLVD PG
Sbjct: 363 TISLNVKGPGLQRMVLVDLPG 383
>gi|18860831 optic atrophy 1 isoform 2 [Homo sapiens]
Length = 924
Score = 36.2 bits (82), Expect = 0.11
Identities = 52/201 (25%), Positives = 87/201 (43%), Gaps = 31/201 (15%)
Query: 9 KHF--VLAKKAITAIFDQLLEFVTEGSHFVEATYK-NPELDRIATEDDLVEMQGYKDKLS 65
KHF V K+ I + ++LL + +E K N EL ++ + D + K K S
Sbjct: 168 KHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKS 227
Query: 66 II---GEVL-----------SRRHM-KVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-IT 109
+I EVL ++ H+ +V G S+GK+SV+ + ++ P G G +T
Sbjct: 228 LIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMT 287
Query: 110 NCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALH-----MDKDLKAGCLVRVFWPK 164
+ V ++G + + S + + LA H M K++K GC V P+
Sbjct: 288 RSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS---PE 344
Query: 165 AKCALLR----DDLVLVDSPG 181
++ +VLVD PG
Sbjct: 345 TISLNVKGPGLQRMVLVDLPG 365
>gi|224831243 optic atrophy 1 isoform 1 [Homo sapiens]
Length = 960
Score = 36.2 bits (82), Expect = 0.11
Identities = 52/201 (25%), Positives = 87/201 (43%), Gaps = 31/201 (15%)
Query: 9 KHF--VLAKKAITAIFDQLLEFVTEGSHFVEATYK-NPELDRIATEDDLVEMQGYKDKLS 65
KHF V K+ I + ++LL + +E K N EL ++ + D + K K S
Sbjct: 204 KHFRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKS 263
Query: 66 II---GEVL-----------SRRHM-KVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-IT 109
+I EVL ++ H+ +V G S+GK+SV+ + ++ P G G +T
Sbjct: 264 LIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMT 323
Query: 110 NCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALH-----MDKDLKAGCLVRVFWPK 164
+ V ++G + + S + + LA H M K++K GC V P+
Sbjct: 324 RSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS---PE 380
Query: 165 AKCALLR----DDLVLVDSPG 181
++ +VLVD PG
Sbjct: 381 TISLNVKGPGLQRMVLVDLPG 401
>gi|153945715 myosin VC [Homo sapiens]
Length = 1742
Score = 36.2 bits (82), Expect = 0.11
Identities = 49/209 (23%), Positives = 85/209 (40%), Gaps = 41/209 (19%)
Query: 262 HFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKA----QGMPESGVALAEGFHARLQEF 317
H LVE+L + AL A + V + L A +KA + E G + +L +
Sbjct: 906 HGLVEKLTSLAALRAGD----VEKIQKLEAELEKAATHRRNYEEKGKRYRDAVEEKLAKL 961
Query: 318 QNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQI 377
Q S ++T+ EQ ++ ++ +K MD NL + EER+ +
Sbjct: 962 QKHN---------SELETQKEQIQLKLQEKTEELKEKMD--NLTKQLFDDVQKEERQRML 1010
Query: 378 DRLDFIRNQMNLLTLDVKKKIKEVTEEVA----------------NKVSCAMTDEICRLS 421
+ L T D +K+I+ + EE+ + S + E+ RLS
Sbjct: 1011 -----LEKSFELKTQDYEKQIQSLKEEIKALKDEKMQLQHLVEGEHVTSDGLKAEVARLS 1065
Query: 422 VLVDEFCSEFHPNPDVLKIYKSELNKHIE 450
V SEF ++L+ K ++ KH++
Sbjct: 1066 KQVKTI-SEFEKEIELLQAQKIDVEKHVQ 1093
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 35.4 bits (80), Expect = 0.19
Identities = 98/511 (19%), Positives = 195/511 (38%), Gaps = 72/511 (14%)
Query: 270 VVNALEAQNRIFFVSAKEV----LSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFE 325
V LE N+I +EV L A ++ A+ + +S ++++ +++RL FQN +I +
Sbjct: 1858 VSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEK 1917
Query: 326 ECISQSAVKTKFEQHTIRA----KQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLD 381
+ + + +RA K ++ K +++ D + +++ ED +
Sbjct: 1918 TKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDV---DSLNLCLQQYEDLKQPMA 1974
Query: 382 FIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIY 441
+ Q++ L D++ I E ++++ + + M + L + + D L+ +
Sbjct: 1975 ERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGH 2034
Query: 442 KSELNKHIEDGMGRNLADRCTDEVNAL---VLQTQQEIIENLKPLLPAGIQDKLHTLIPC 498
++ + + + C ++ L V Q ++ + AG Q +
Sbjct: 2035 LQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERAL---------AGHQGRT------ 2079
Query: 499 KKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLG------PRNAQRVLLGLSEPI 552
+ DLS D Q+DI R + ++++V G + + R L L E +
Sbjct: 2080 TQQDLSALQKNQSDLKDLQDDIQNR-ATSFATVVKDIEGFMEENQTKLSPRELTALREKL 2138
Query: 553 FQLP--------------RSLASTPTAPTTPATPDNASQEELMIT---LVTGLASVTSRT 595
Q + L T+ T + + +EL + L VTS
Sbjct: 2139 HQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVG 2198
Query: 596 SMGIIIVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQ----------- 644
S G G ++ G + LS + GAL + A E+ KQ
Sbjct: 2199 SSG----GQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQEL 2254
Query: 645 --QFVNY--ATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPK 700
Q N+ AT+ + + N + + +Q + L +Q + Q E E+ ++
Sbjct: 2255 LSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQT 2314
Query: 701 EIDQLEKIQNNSKLLRNKAVQLENELENFTK 731
D+L+K + K + + E ELEN K
Sbjct: 2315 LQDELQKFLQDHKEFESWLERSEKELENMHK 2345
>gi|75750474 spectrin domain with coiled-coils 1 NSP5a3b [Homo
sapiens]
Length = 987
Score = 35.4 bits (80), Expect = 0.19
Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 11/101 (10%)
Query: 289 LSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSA--------VKTKFEQH 340
L++ +K Q M E+ + AE A LQE + +Q+ +E +++ ++T F QH
Sbjct: 289 LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQH 348
Query: 341 TIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLD 381
RA+Q+ + +M NL E ++ +E +I L+
Sbjct: 349 RERAEQLSQENEKLM---NLLQERVKNEEPTTQEGKIIELE 386
>gi|75750468 spectrin domain with coiled-coils 1 NSP5a3a [Homo
sapiens]
Length = 709
Score = 35.4 bits (80), Expect = 0.19
Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 11/101 (10%)
Query: 289 LSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSA--------VKTKFEQH 340
L++ +K Q M E+ + AE A LQE + +Q+ +E +++ ++T F QH
Sbjct: 289 LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQH 348
Query: 341 TIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLD 381
RA+Q+ + +M NL E ++ +E +I L+
Sbjct: 349 RERAEQLSQENEKLM---NLLQERVKNEEPTTQEGKIIELE 386
>gi|75750472 spectrin domain with coiled-coils 1 NSP5b3b [Homo
sapiens]
Length = 1068
Score = 35.4 bits (80), Expect = 0.19
Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 11/101 (10%)
Query: 289 LSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSA--------VKTKFEQH 340
L++ +K Q M E+ + AE A LQE + +Q+ +E +++ ++T F QH
Sbjct: 370 LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQH 429
Query: 341 TIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLD 381
RA+Q+ + +M NL E ++ +E +I L+
Sbjct: 430 RERAEQLSQENEKLM---NLLQERVKNEEPTTQEGKIIELE 467
>gi|75750466 spectrin domain with coiled-coils 1 NSP5b3a [Homo
sapiens]
Length = 790
Score = 35.4 bits (80), Expect = 0.19
Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 11/101 (10%)
Query: 289 LSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSA--------VKTKFEQH 340
L++ +K Q M E+ + AE A LQE + +Q+ +E +++ ++T F QH
Sbjct: 370 LASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKTILETSFHQH 429
Query: 341 TIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLD 381
RA+Q+ + +M NL E ++ +E +I L+
Sbjct: 430 RERAEQLSQENEKLM---NLLQERVKNEEPTTQEGKIIELE 467
>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2
[Homo sapiens]
Length = 1235
Score = 35.4 bits (80), Expect = 0.19
Identities = 86/350 (24%), Positives = 138/350 (39%), Gaps = 71/350 (20%)
Query: 212 LMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQH--MERCLHFLVEELK 269
L + EK H +N +L N + R S E ++ +++H + R L +ELK
Sbjct: 228 LYHNEKKI-HLLNTKLEHVNRDLSVKRESLSHHE-NIVKARKKEHGMLTRQLQQTEKELK 285
Query: 270 VVNALEAQNRIFFVSAKEVLS--------ARK-----QKAQGMPESGVALAEGFHARLQ- 315
V L Q R ++ AKE S A+K +K E + E A L
Sbjct: 286 SVETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELADLDA 345
Query: 316 EFQNFEQIFEECISQSAVKTKFEQHTI-RAKQILATVKNIM----------------DSV 358
+++FE+ EE I + E + R K++ V+ + D
Sbjct: 346 AWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWEQKTDEE 405
Query: 359 NLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEIC 418
LA E +RH V+ L I+ Q+ D KK+I+++ E + C + ++
Sbjct: 406 RLAFEKRRHGEVQ------GNLKQIKEQIE----DHKKRIEKLEEYTKTCMDC-LKEKKQ 454
Query: 419 RLSVLVDEF------CSEFHPNPDVLKIYKSEL-NKHIEDGMGRNLADRCTDEVNALVLQ 471
+ LVDE SEF+ + L + +SEL N I+ G+ Q
Sbjct: 455 QEETLVDEIEKTKSRMSEFN---EELNLIRSELQNAGIDTHEGKR-------------QQ 498
Query: 472 TQQEIIENLKPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIV 521
+ E++E+LK L P + +L L C Y L K+ F IV
Sbjct: 499 KRAEVLEHLKRLYPDSVFGRLFDL--CHPIHKKYQLAVTKVFGRFITAIV 546
>gi|224831253 optic atrophy 1 isoform 8 [Homo sapiens]
Length = 1015
Score = 34.7 bits (78), Expect = 0.33
Identities = 50/199 (25%), Positives = 85/199 (42%), Gaps = 29/199 (14%)
Query: 9 KHFVLAKKAITAIFDQLLEFVTEGSHFVEATYK-NPELDRIATEDDLVEMQGYKDKLSII 67
K V K+ I + ++LL + +E K N EL ++ + D + K K S+I
Sbjct: 261 KRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLI 320
Query: 68 ---GEVL-----------SRRHM-KVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-ITNC 111
EVL ++ H+ +V G S+GK+SV+ + ++ P G G +T
Sbjct: 321 DMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRS 380
Query: 112 FLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALH-----MDKDLKAGCLVRVFWPKAK 166
+ V ++G + + S + + LA H M K++K GC V P+
Sbjct: 381 PVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS---PETI 437
Query: 167 CALLR----DDLVLVDSPG 181
++ +VLVD PG
Sbjct: 438 SLNVKGPGLQRMVLVDLPG 456
>gi|224831251 optic atrophy 1 isoform 7 [Homo sapiens]
Length = 997
Score = 34.7 bits (78), Expect = 0.33
Identities = 50/199 (25%), Positives = 85/199 (42%), Gaps = 29/199 (14%)
Query: 9 KHFVLAKKAITAIFDQLLEFVTEGSHFVEATYK-NPELDRIATEDDLVEMQGYKDKLSII 67
K V K+ I + ++LL + +E K N EL ++ + D + K K S+I
Sbjct: 243 KRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLI 302
Query: 68 ---GEVL-----------SRRHM-KVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-ITNC 111
EVL ++ H+ +V G S+GK+SV+ + ++ P G G +T
Sbjct: 303 DMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRS 362
Query: 112 FLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALH-----MDKDLKAGCLVRVFWPKAK 166
+ V ++G + + S + + LA H M K++K GC V P+
Sbjct: 363 PVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS---PETI 419
Query: 167 CALLR----DDLVLVDSPG 181
++ +VLVD PG
Sbjct: 420 SLNVKGPGLQRMVLVDLPG 438
>gi|18860841 optic atrophy 1 isoform 6 [Homo sapiens]
Length = 979
Score = 34.7 bits (78), Expect = 0.33
Identities = 50/199 (25%), Positives = 85/199 (42%), Gaps = 29/199 (14%)
Query: 9 KHFVLAKKAITAIFDQLLEFVTEGSHFVEATYK-NPELDRIATEDDLVEMQGYKDKLSII 67
K V K+ I + ++LL + +E K N EL ++ + D + K K S+I
Sbjct: 225 KRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLI 284
Query: 68 ---GEVL-----------SRRHM-KVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-ITNC 111
EVL ++ H+ +V G S+GK+SV+ + ++ P G G +T
Sbjct: 285 DMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRS 344
Query: 112 FLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALH-----MDKDLKAGCLVRVFWPKAK 166
+ V ++G + + S + + LA H M K++K GC V P+
Sbjct: 345 PVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS---PETI 401
Query: 167 CALLR----DDLVLVDSPG 181
++ +VLVD PG
Sbjct: 402 SLNVKGPGLQRMVLVDLPG 420
>gi|18860835 optic atrophy 1 isoform 4 [Homo sapiens]
Length = 961
Score = 34.7 bits (78), Expect = 0.33
Identities = 50/199 (25%), Positives = 85/199 (42%), Gaps = 29/199 (14%)
Query: 9 KHFVLAKKAITAIFDQLLEFVTEGSHFVEATYK-NPELDRIATEDDLVEMQGYKDKLSII 67
K V K+ I + ++LL + +E K N EL ++ + D + K K S+I
Sbjct: 207 KRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRKLVLQKDDKGIHHRKLKKSLI 266
Query: 68 ---GEVL-----------SRRHM-KVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-ITNC 111
EVL ++ H+ +V G S+GK+SV+ + ++ P G G +T
Sbjct: 267 DMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRS 326
Query: 112 FLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALH-----MDKDLKAGCLVRVFWPKAK 166
+ V ++G + + S + + LA H M K++K GC V P+
Sbjct: 327 PVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVS---PETI 383
Query: 167 CALLR----DDLVLVDSPG 181
++ +VLVD PG
Sbjct: 384 SLNVKGPGLQRMVLVDLPG 402
>gi|197116359 inositol polyphosphate-4-phosphatase, type 1 isoform d
[Homo sapiens]
Length = 977
Score = 34.3 bits (77), Expect = 0.43
Identities = 17/57 (29%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 309 GFHARLQEFQNFEQIFEECISQSAVKT--KFEQHTIRAKQILATVKNIMDSVNLAAE 363
G +L +F+ ++ FEEC + S ++ Q +RAK+I+A + + V+ AE
Sbjct: 374 GLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAE 430
>gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform b
[Homo sapiens]
Length = 954
Score = 34.3 bits (77), Expect = 0.43
Identities = 17/57 (29%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 309 GFHARLQEFQNFEQIFEECISQSAVKT--KFEQHTIRAKQILATVKNIMDSVNLAAE 363
G +L +F+ ++ FEEC + S ++ Q +RAK+I+A + + V+ AE
Sbjct: 374 GLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAE 430
>gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform a
[Homo sapiens]
Length = 938
Score = 34.3 bits (77), Expect = 0.43
Identities = 17/57 (29%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 309 GFHARLQEFQNFEQIFEECISQSAVKT--KFEQHTIRAKQILATVKNIMDSVNLAAE 363
G +L +F+ ++ FEEC + S ++ Q +RAK+I+A + + V+ AE
Sbjct: 374 GLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAE 430
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 33.9 bits (76), Expect = 0.56
Identities = 57/252 (22%), Positives = 104/252 (41%), Gaps = 31/252 (12%)
Query: 222 KVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVNA--LEAQNR 279
KV +R + + N +W ++ + + V RQ E EEL V L A+NR
Sbjct: 810 KVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAK--EEELVKVREKQLAAENR 867
Query: 280 IFFVSA-KEVLSARKQKAQGMPESGVAL---AEGFHARLQ-EFQNFEQIFEECISQSAVK 334
+ + + L A K + Q ++ L AE ARL + Q E+I + ++
Sbjct: 868 LTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHD------LE 921
Query: 335 TKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDV 394
+ E+ R + + A K K +++E E+Q++ + R ++ L +
Sbjct: 922 ARVEEEEERCQHLQAEKK------------KMQQNIQELEEQLEEEESARQKLQLEKVTT 969
Query: 395 KKKIKEVTEE--VANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDG 452
+ K+K++ EE + +C + E L + EF + + K NKH +
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKH--EA 1027
Query: 453 MGRNLADRCTDE 464
M +L +R E
Sbjct: 1028 MITDLEERLRRE 1039
Score = 31.2 bits (69), Expect = 3.6
Identities = 21/94 (22%), Positives = 45/94 (47%), Gaps = 1/94 (1%)
Query: 635 THAKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDITQKQLEEE 694
T +ER +++ EK R + S + S Q+ + + A L Q+ +++L+
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE-LQAQIAELKMQLAKKEEELQAA 1088
Query: 695 IARLPKEIDQLEKIQNNSKLLRNKAVQLENELEN 728
+AR+ +E Q + L ++ +L+ +LE+
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
>gi|4505047 lumican precursor [Homo sapiens]
Length = 338
Score = 33.9 bits (76), Expect = 0.56
Identities = 24/98 (24%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 613 KLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQ 672
KL SV + G YLY R + H E+AF+ L+ ++ + + ++K +
Sbjct: 57 KLKSVPMVPPGIKYLYLRNNQIDHIDEKAFEN------VTDLQWLILDHNLLENSKIKGR 110
Query: 673 IATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQN 710
+ + +L +++ I L E + LPK ++ L+ N
Sbjct: 111 VFSKLKQL-KKLHINHNNLTESVGPLPKSLEDLQLTHN 147
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 33.9 bits (76), Expect = 0.56
Identities = 36/148 (24%), Positives = 73/148 (49%), Gaps = 20/148 (13%)
Query: 325 EEC--ISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDF 382
EEC + ++ K++F++ ++AKQ+ T + + L AE + +VEE+ + +
Sbjct: 866 EECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWL----- 920
Query: 383 IRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLK--I 440
I++++ L + ++KE++E V + + E+ +++ C E D L+ +
Sbjct: 921 IKSKIQL-----EARVKELSERVEEEEE--INSELTARGRKLEDECFELKKEIDDLETML 973
Query: 441 YKSELNKHIEDGMGRNLADRCTDEVNAL 468
KSE K + +NL T+EV L
Sbjct: 974 VKSEKEKRTTEHKVKNL----TEEVEFL 997
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 33.9 bits (76), Expect = 0.56
Identities = 28/104 (26%), Positives = 50/104 (48%), Gaps = 5/104 (4%)
Query: 629 ERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSANCSH---QVKQQIATTFARLCQQVD 685
+RLSW +QQ + E+L+ +V +T A +H +V+Q + + + ++
Sbjct: 1840 KRLSWDKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLN 1899
Query: 686 I--TQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLENELE 727
T E+E L +E DQ +K Q+ + ++ LE ELE
Sbjct: 1900 PSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELE 1943
Score = 31.2 bits (69), Expect = 3.6
Identities = 33/163 (20%), Positives = 74/163 (45%), Gaps = 24/163 (14%)
Query: 326 ECISQSA--VKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFI 383
+C+ + ++T++++ K++ A V + D + E + E+ D +
Sbjct: 1266 DCLQEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKS--YDEVKIE 1323
Query: 384 RNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKS 443
++N+L L ++ KI+++ E V + C + + L L E P+ ++L
Sbjct: 1324 NEELNVLVLRLQGKIEKLQESVVQRCDCCLWE--ASLENL------EIEPDGNIL----- 1370
Query: 444 ELNKHIEDGMGR-----NLADRCTDEVNALVLQTQQEIIENLK 481
+LN+ +E+ + R ++ + C E L TQ ++E +K
Sbjct: 1371 QLNQTLEECVPRVRSVHHVIEECKQENQYLEGNTQ--LLEKVK 1411
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,810,745
Number of Sequences: 37866
Number of extensions: 1093986
Number of successful extensions: 5024
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 4852
Number of HSP's gapped (non-prelim): 293
length of query: 741
length of database: 18,247,518
effective HSP length: 110
effective length of query: 631
effective length of database: 14,082,258
effective search space: 8885904798
effective search space used: 8885904798
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.