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Search of human proteins with 45120119
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45120119 microtubule associated serine/threonine kinase 1
[Homo sapiens]
(1570 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 3147 0.0
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 1773 0.0
gi|148727255 microtubule associated serine/threonine kinase fami... 1608 0.0
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 1421 0.0
gi|4502023 AKT2 kinase [Homo sapiens] 230 9e-60
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 228 4e-59
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 228 4e-59
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 223 9e-58
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 222 3e-57
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 222 3e-57
gi|62241015 AKT1 kinase [Homo sapiens] 221 3e-57
gi|62241013 AKT1 kinase [Homo sapiens] 221 3e-57
gi|62241011 AKT1 kinase [Homo sapiens] 221 3e-57
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 221 3e-57
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 219 1e-56
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 219 1e-56
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 219 2e-56
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 218 3e-56
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 218 5e-56
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 217 8e-56
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 216 1e-55
gi|5453974 protein kinase N2 [Homo sapiens] 215 2e-55
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 214 4e-55
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 214 4e-55
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 214 5e-55
gi|28557781 protein kinase C, eta [Homo sapiens] 214 7e-55
gi|5453976 protein kinase C, theta [Homo sapiens] 214 7e-55
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 213 1e-54
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 213 1e-54
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 213 1e-54
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 3147 bits (8160), Expect = 0.0
Identities = 1570/1570 (100%), Positives = 1570/1570 (100%)
Query: 1 MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSS 60
MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSS
Sbjct: 1 MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSS 60
Query: 61 PLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQ 120
PLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQ
Sbjct: 61 PLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQ 120
Query: 121 LPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNH 180
LPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNH
Sbjct: 121 LPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNH 180
Query: 181 VYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLI 240
VYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLI
Sbjct: 181 VYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLI 240
Query: 241 TTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFY 300
TTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFY
Sbjct: 241 TTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFY 300
Query: 301 HLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEG 360
HLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEG
Sbjct: 301 HLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEG 360
Query: 361 RSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAF 420
RSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAF
Sbjct: 361 RSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAF 420
Query: 421 VERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAE 480
VERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAE
Sbjct: 421 VERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAE 480
Query: 481 TVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAR 540
TVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAR
Sbjct: 481 TVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAR 540
Query: 541 EFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI 600
EFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI
Sbjct: 541 EFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI 600
Query: 601 SDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKA 660
SDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKA
Sbjct: 601 SDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKA 660
Query: 661 EFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQ 720
EFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQ
Sbjct: 661 EFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQ 720
Query: 721 LSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASE 780
LSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASE
Sbjct: 721 LSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASE 780
Query: 781 ASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKE 840
ASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKE
Sbjct: 781 ASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKE 840
Query: 841 ETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEK 900
ETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEK
Sbjct: 841 ETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEK 900
Query: 901 RPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPA 960
RPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPA
Sbjct: 901 RPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPA 960
Query: 961 VSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLI 1020
VSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLI
Sbjct: 961 VSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLI 1020
Query: 1021 THVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRP 1080
THVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRP
Sbjct: 1021 THVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRP 1080
Query: 1081 SAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHS 1140
SAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHS
Sbjct: 1081 SAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHS 1140
Query: 1141 YRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAG 1200
YRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAG
Sbjct: 1141 YRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAG 1200
Query: 1201 NIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPL 1260
NIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPL
Sbjct: 1201 NIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPL 1260
Query: 1261 LKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGL 1320
LKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGL
Sbjct: 1261 LKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGL 1320
Query: 1321 GAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGR 1380
GAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGR
Sbjct: 1321 GAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGR 1380
Query: 1381 TLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEP 1440
TLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEP
Sbjct: 1381 TLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEP 1440
Query: 1441 ARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPAS 1500
ARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPAS
Sbjct: 1441 ARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPAS 1500
Query: 1501 PKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKK 1560
PKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKK
Sbjct: 1501 PKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKK 1560
Query: 1561 GVSSPAPPGP 1570
GVSSPAPPGP
Sbjct: 1561 GVSSPAPPGP 1570
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 1773 bits (4593), Expect = 0.0
Identities = 991/1590 (62%), Positives = 1142/1590 (71%), Gaps = 129/1590 (8%)
Query: 13 SMPSFPGG----SMFRRTKSCRTSNRKSLILTS-TSPTLPRPHSPLPGHLGSSPLDSPRN 67
S PS G S+ RR CRTSNRKSLI+TS TSPTLPRPHSPL GH G+SPLDSPRN
Sbjct: 148 SAPSLTAGLKELSLPRRGSFCRTSNRKSLIVTSSTSPTLPRPHSPLHGHTGNSPLDSPRN 207
Query: 68 FSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTV 127
FSPN PAHFSF +RR DGRRWSLASLPSSGYGTNTPSSTVSSSCSSQE+LHQLP+QPT
Sbjct: 208 FSPNAPAHFSFVPARRTDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPFQPTA 267
Query: 128 DELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFP 187
DELHFL+KHF STES+ DE+G R+SPA+RPRSRSLSPGRSP S+D+EI+MMNHVYKERFP
Sbjct: 268 DELHFLTKHF-STESVPDEEG-RQSPAMRPRSRSLSPGRSPVSFDSEIIMMNHVYKERFP 325
Query: 188 KATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYE 247
KATAQMEE+L +F + PDSVLPLADG LSFIHHQ+IE+ARDCL KSR GLIT+ YFYE
Sbjct: 326 KATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLITSQYFYE 385
Query: 248 LQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAE 307
LQ+NLEKLLQDA+ERSES EVAFV QLVKKL+III+RPARLLECLEF+PEEFYHLLEAAE
Sbjct: 386 LQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAE 445
Query: 308 GHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEGRSSK--A 365
GHAKEG +K DIPRYI+ QLGLTRDP ++ L DS +TPE DD EG + +
Sbjct: 446 GHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDS--PDTPETDDSIEGHGASLPS 503
Query: 366 KKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDI 425
KK P E DF+TIKLISNGAYGAV+LVRH+ TRQRFAMKKINKQNLILRNQIQQAFVERDI
Sbjct: 504 KKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDI 563
Query: 426 LTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLAL 485
LTFAENPFVV MFCSF+T+RHLCMVMEYVEGGDCATLLKNIGALPV+M R+YFAETVLAL
Sbjct: 564 LTFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLAL 623
Query: 486 EYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDK 545
EYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSK+GLMSLTTNLYEGHIEKDAREFLDK
Sbjct: 624 EYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDK 683
Query: 546 QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDIL 605
QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISD+I+
Sbjct: 684 QVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIV 743
Query: 606 WPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPH 665
WPEGDEALP +AQ L S LL NPL RLG G A+EVKQH FF LDWTGLLRQKAEFIP
Sbjct: 744 WPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQ 803
Query: 666 LESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLS-QH 724
LESEDDTSYFDTRS+RYHH++S DE++ +E+ +EIRQFSSCSPRF+KVYSSME+LS
Sbjct: 804 LESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLE 863
Query: 725 EPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEI--KRFSASEAS 782
E +TP P+ + E+ +GL GL R+++W GSPEI KR S SE+S
Sbjct: 864 ERRTP---------PPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESS 914
Query: 783 FLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPS----SDPAGS------ 832
E ++SPP+ RRR S LL+ RF E E + LRR P+ + P+G
Sbjct: 915 HTESDSSPPMTVRRRCSGLLDAPRFPEGPE-EASSTLRRQPQEGIWVLTPPSGEGVSGPV 973
Query: 833 ---LDARAPKEETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARH 889
+ PK + + G SS G S A + G S+ + + +A +DL +RRARH
Sbjct: 974 TEHSGEQRPKLDEEAVGRSS-GSSPAMETRGRG----TSQLAEGATAKAISDLAVRRARH 1028
Query: 890 QQMSGDVAVEKRPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSR 949
+ +SGD + EKR +R KVIKSASATALS++IP+ + H SPLASPMSP S SSNPSSR
Sbjct: 1029 RLLSGD-STEKRTARPVNKVIKSASATALSLLIPS-EHHTCSPLASPMSPHSQSSNPSSR 1086
Query: 950 DSSPSRDYSPAVSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPA 1009
DSSPSRD+ PA+ +R PI I R+GKKYGFTLRAIRVYMGD+DVY+VHH+VWHVE+GGPA
Sbjct: 1087 DSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYTVHHMVWHVEDGGPA 1146
Query: 1010 QEAGLCAGDLITHVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSY 1069
EAGL GDLITHVNGEPVHG+VH EVVELILKSGNKVA++TTP ENTSI++GPAR+ SY
Sbjct: 1147 SEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIKVGPARKGSY 1206
Query: 1070 KAKMARRNKRPSAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPT 1129
KAKMARR+KR K+GQES+KRSSLFRKITKQ++LLHTSRSLSSLNRSLSS +S PGSPT
Sbjct: 1207 KAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGPGSPT 1266
Query: 1130 --HGLPARSPTHSYRSTPDSAYL--GASSQSSSPASSTPNSPASSASHHIRPSTLHGLSP 1185
H L RSPT YR TPD+ + G SSQSSSP+SS P+SPA S H RPS+LHGL+P
Sbjct: 1267 HSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSG--HTRPSSLHGLAP 1324
Query: 1186 KLHRQYRSARCKSAGNIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPV 1245
KL RQYRS R KSAG+IPLSPLAHTPSP + P + S H Q+FP KLH SPP+
Sbjct: 1325 KLQRQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGHVAQAFPTKLHLSPPL 1384
Query: 1246 VR--PRPKSAEPPRSPLLKRVQSAEKLGASLSADKK--GALRKHSLEVGHPDFRKDFHGE 1301
R RPKSAEPPRSPLLKRVQSAEKL A+L+A +K RKHSL++ H + +K
Sbjct: 1385 GRQLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKK----- 1439
Query: 1302 LALHSLAESDGETPPVEGLGAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKE 1361
E PP R+ SPL + +R +S K
Sbjct: 1440 -----------ELPP----------------REVSPLEV--------VGARSVLSGKGAL 1464
Query: 1362 SPGGAEACTPPRATTPGGRTLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETG 1421
G P RA TL +D R +S+Q ++ + S + E G
Sbjct: 1465 PGKGVLQPAPSRAL----GTLRQD-RAERRESLQKQE--------AIREVDSSEDDTEEG 1511
Query: 1422 RRSSSGEAGTPLVPIVVEPARPGAKAVVPQPLGADSKGLQEPAP------LAPSVPEAPR 1475
+S G L P P V P GA G ++P P L P VP
Sbjct: 1512 PENSQGAQELSLAP------HPEVSQSV-APKGAGESGEEDPFPSRDPRSLGPMVPSLLT 1564
Query: 1476 GRERWVLEVVEERTTLSGPRSKPASPKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGS 1535
G + + SGP + SP+ E + S A S A P+PP +
Sbjct: 1565 G----ITLGPPRMESPSGPHRRLGSPQAIEEAASSSSAGPNL-GQSGATDPIPPEGCWKA 1619
Query: 1536 GTKPQVGLTSRCPAEAVPPAGLTKKGVSSP 1565
LT+ P+ +GLT SP
Sbjct: 1620 QHLHTQALTALSPS----TSGLTPTSSCSP 1645
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 1608 bits (4163), Expect = 0.0
Identities = 876/1353 (64%), Positives = 1013/1353 (74%), Gaps = 78/1353 (5%)
Query: 27 KSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSFASSRRADG 86
K CRTSNRKSLI SP LPRPHSPL H G+SP DSPRNFSP+ AHFSFA RR DG
Sbjct: 35 KRCRTSNRKSLIGNGQSPALPRPHSPLSAHAGNSPQDSPRNFSPSASAHFSFA--RRTDG 92
Query: 87 RRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGSTESITDE 146
RRWSLASLPSSGYGTNTPSSTVSSSCSSQE+LHQLPYQPT DELHFLSKHF +TESI E
Sbjct: 93 RRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPYQPTPDELHFLSKHFCTTESIATE 152
Query: 147 DGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFTRAYEP 206
+ R +P +RPRSRSLSPGRSP+ D+EI+MMNHVYKERFPKATAQMEE+L++ +Y P
Sbjct: 153 NRCRNTP-MRPRSRSLSPGRSPACCDHEIIMMNHVYKERFPKATAQMEERLKEIITSYSP 211
Query: 207 DSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESL 266
D+VLPLADGVLSF HHQIIELARDCL KS GLIT+ YF ELQ L+KLLQ+A++RSES
Sbjct: 212 DNVLPLADGVLSFTHHQIIELARDCLDKSHQGLITSRYFLELQHKLDKLLQEAHDRSESG 271
Query: 267 EVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIR 326
E+AF+ QLV+K+LI+I+RPARLLECLEF+PEEFY+LLEAAEGHAKEG +KTDIPRYII
Sbjct: 272 ELAFIKQLVRKILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTDIPRYIIS 331
Query: 327 QLGLTRDPFPDVVHLEEQDSGGSNTPEQDDL--SEGRSSKAKKPPGENDFDTIKLISNGA 384
QLGL +DP ++ HL DSG + TPE D+ S S K ++ P E+DF+TIKLISNGA
Sbjct: 332 QLGLNKDPLEEMAHLGNYDSGTAETPETDESVSSSNASLKLRRKPRESDFETIKLISNGA 391
Query: 385 YGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETR 444
YGAVY VRH+++RQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVV M+CSFETR
Sbjct: 392 YGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMYCSFETR 451
Query: 445 RHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLL 504
RHLCMVMEYVEGGDCATL+KN+G LPV+MARMYFAETVLALEYLHNYGIVHRDLKPDNLL
Sbjct: 452 RHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLALEYLHNYGIVHRDLKPDNLL 511
Query: 505 ITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY 564
+TSMGHIKLTDFGLSK+GLMS+TTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY
Sbjct: 512 VTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGY 571
Query: 565 GKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSL 624
GKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISD+I WPE DEA P +AQ LI+ L
Sbjct: 572 GKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPPPDAQDLITLL 631
Query: 625 LQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSDRYHH 684
L+ NPL RLG GGA+EVKQH FFR LDW LLRQKAEFIP LESEDDTSYFDTRS++YHH
Sbjct: 632 LRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQKAEFIPQLESEDDTSYFDTRSEKYHH 691
Query: 685 VNSYDEDDTTEEE-PVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAAAGSSKREPSTK 743
+ + +EDDT +E+ VEIRQFSSCS RFSKV+SS+++++Q+ + ++E S
Sbjct: 692 METEEEDDTNDEDFNVEIRQFSSCSHRFSKVFSSIDRITQN---------SAEEKEDSVD 742
Query: 744 GPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARRRFSALLE 803
+ E L +W E+++ S S +S E R + S+ L
Sbjct: 743 KTKSTTLPSTETL--------SWSSEYSEMQQLSTSNSSDTESN-------RHKLSSGLL 787
Query: 804 PSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKEETQGE------------GTSSAG 851
P + + ++DEA P P +P A P+E Q E T S G
Sbjct: 788 PKLAISTEGEQDEA-ASCPGDPHEEP--GKPALPPEECAQEEPEVTTPASTISSSTLSVG 844
Query: 852 D-SEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEKRPSRTGGKVI 910
SE D+ C S D ++S P + A H + EK+ + GKV
Sbjct: 845 SFSEHLDQINGRSECVDSTD-NSSKPSS------EPASHMARQRLESTEKK--KISGKVT 895
Query: 911 KSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNP-SSRDSSPSRDYSPAVSGLRSPIT 969
KS SA+ALS+MIP D SPL SPMSP SLSS+P SSRDSSPSRD S A + PI
Sbjct: 896 KSLSASALSLMIPG-DMFAVSPLGSPMSPHSLSSDPSSSRDSSPSRDSSAASASPHQPIV 954
Query: 970 IQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPVH 1029
I SGK YGFT+RAIRVY+GD+D+Y+VHHIVW+VEEG PA +AGL AGDLITH+NGEPVH
Sbjct: 955 IHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQAGLKAGDLITHINGEPVH 1014
Query: 1030 GMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRPSAKEGQESK 1089
G+VH EV+EL+LKSGNKV++TTTPFENTSI+ GPARR+SYK++M RR+K+ KE E
Sbjct: 1015 GLVHTEVIELLLKSGNKVSITTTPFENTSIKTGPARRNSYKSRMVRRSKKSKKKESLE-- 1072
Query: 1090 KRSSLFRKITKQ-SNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRSTPDSA 1148
+R SLF+K+ KQ S LLHTSRS S LNRSLSS +SLPGSPTH L RSPT SYRSTPD
Sbjct: 1073 RRRSLFKKLAKQPSPLLHTSRSFSCLNRSLSSGESLPGSPTHSLSPRSPTPSYRSTPDFP 1132
Query: 1149 YLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQ-YRSARCKSAGNIPLSPL 1207
SSQSSSP+SS PNSPA S HIRPSTLHGL+PKL Q YRS R KSAGNIPLSPL
Sbjct: 1133 SGTNSSQSSSPSSSAPNSPAGSG--HIRPSTLHGLAPKLGGQRYRSGRRKSAGNIPLSPL 1190
Query: 1208 AHTPSPT------QASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVR--PRPKSAEPPRSP 1259
A TPSPT Q SP PL GH++G+S Q+FP+K+HS P +VR RPKSAEPPRSP
Sbjct: 1191 ARTPSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSP 1250
Query: 1260 LLKRVQSAEKLGASLSADKKG-ALRKHSLEVGHPDF-RKDFHGELALHSLAESDGETPPV 1317
LLKRVQS EKL S +DKK RKHSLEV + R+ E L SL E+ + PP+
Sbjct: 1251 LLKRVQSEEKLSPSYGSDKKHLCSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPL 1310
Query: 1318 EGL-----GAPRQVAVRRLGRQESPLSLGADPL 1345
G ++ R++GRQES L D L
Sbjct: 1311 SRARPVEQGCLKRPVSRKVGRQESVDDLDRDKL 1343
Score = 47.8 bits (112), Expect = 9e-05
Identities = 107/473 (22%), Positives = 169/473 (35%), Gaps = 65/473 (13%)
Query: 1072 KMARRNKRPSAKEGQESKKRSSLFRKITKQSNLLHTS--RSLSSLNRSLSSSD-SLPGSP 1128
K R+ P+A+ + + R+ + + HT+ + L+ L ++L S D + P P
Sbjct: 1708 KRDRKGPHPTARSPGTVMESNPQQREGSSPKHQDHTTDPKLLTCLGQNLHSPDLARPRCP 1767
Query: 1129 THGLPARSPTHSYRSTPDSAYLG---ASSQSSSPASSTPNSPA------SSASHHIRPST 1179
P SP+ +S+ G A S+ S+ + T P+ +A
Sbjct: 1768 LP--PEASPSREKPGLRESSERGPPTARSERSAARADTCREPSMELCFPETAKTSDNSKN 1825
Query: 1180 LHGLSPKLHRQYRSARCKSAGNIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKL 1239
L + Y + P H P +A PPP ++ S+ +L
Sbjct: 1826 LLSVGRTHPDFYTQTQAMEKAWAPGGKTNHKDGPGEARPPPRDNSSLHSAGIPCE--KEL 1883
Query: 1240 HSSPPVVRPRP------KSAEPP-----RSPLLKRVQSAEKLGASLSADKKGALRKHSLE 1288
V P+P +S +PP +S L S +K GA K+ L++H
Sbjct: 1884 GKVRRGVEPKPEALLARRSLQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQRHPSS 1943
Query: 1289 VGHPDFRKDFHGELALHSLAESDGETPPV-EGLGAPRQVAVRRLGRQES---PLSLGADP 1344
+ P L D +P + +P + R G + S P S DP
Sbjct: 1944 IPPPP-------------LTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQDP 1990
Query: 1345 LLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGRTLERD---VGCTRHQSVQTE---- 1397
P A S K + P PP+ P R+L VG T+ + T+
Sbjct: 1991 PKPVAAHSESSSHKPRPGPDPG----PPKTKHPD-RSLSSQKPSVGATKGKEPATQSLGG 2045
Query: 1398 ---DGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEPARPGAKAVVPQPL- 1453
+G G +P +++ GE G P VP+ + A AK PQP
Sbjct: 2046 SSREGKGHSKSGPDVFPATPGSQNKASDGIGQGEGG-PSVPLHTDRAPLDAK---PQPTS 2101
Query: 1454 -GADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPASPKLSP 1505
G + L++P L P L V E+ TLS KP++ K P
Sbjct: 2102 GGRPLEVLEKPVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCP 2154
Score = 38.9 bits (89), Expect = 0.040
Identities = 113/524 (21%), Positives = 180/524 (34%), Gaps = 112/524 (21%)
Query: 1120 SSDSLPGSPTHGL------PARSPTHSYRSTPDSAYLGA-------------SSQSSSPA 1160
S + LPG+P P S + ++ S+ +A + A S + P
Sbjct: 1525 SHECLPGNPVRPTGGQQEPPPASESRAFVSSTHAAQMSAVSFVPLKALTGRVDSGTEKPG 1584
Query: 1161 SSTPNSPA--SSASHHIRPSTLHGLSP---KLHRQYRSARCKSAGNIPLSPLAHTPSPT- 1214
P SP S + + + ++ L P L S S +P A +PSP+
Sbjct: 1585 LVAPESPVRKSPSEYKLEGRSVSCLKPIEGTLDIALLSGPQASKTELPSPESAQSPSPSG 1644
Query: 1215 --QASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPLLKRVQSAEKLGA 1272
+AS PP+ + G + T S SP ++ + L
Sbjct: 1645 DVRASVPPVLPSSSGKKNDTTS-------------------ARELSPSSLKMNKSYLLEP 1685
Query: 1273 SLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDG---ETPPVEGLGAP------ 1323
+G ++ + P+F++D G H A S G E+ P + G+
Sbjct: 1686 WFLPPSRGLQNSPAVSLPDPEFKRDRKGP---HPTARSPGTVMESNPQQREGSSPKHQDH 1742
Query: 1324 -----------RQVAVRRLGRQESPLSLGADPL-----LPEGASRPPVSSKEKESPGGA- 1366
+ + L R PL A P L E + R P +++ + S A
Sbjct: 1743 TTDPKLLTCLGQNLHSPDLARPRCPLPPEASPSREKPGLRESSERGPPTARSERSAARAD 1802
Query: 1367 -------EACTPPRATTPGGRTLERDVGCTRHQSVQTEDGTGGMARAVAKAALS-----P 1414
E C P A T VG T H T+ T M +A A + P
Sbjct: 1803 TCREPSMELCFPETAKTSDNSKNLLSVGRT-HPDFYTQ--TQAMEKAWAPGGKTNHKDGP 1859
Query: 1415 VQEHETGRRSSS-GEAGTPLVPIVVEPAR---PGAKAVVP----QPLGADSKGLQEPAPL 1466
+ R +SS AG P + + R P +A++ QP G +S+ ++ +
Sbjct: 1860 GEARPPPRDNSSLHSAGIPCEKELGKVRRGVEPKPEALLARRSLQPPGIESEKSEKLSSF 1919
Query: 1467 APSVPEAPRGRERWVLEVVEERTTLSGPRSKPASPKLSPEPQTPSLAPAKCSAPSSAVTP 1526
+ + ER +E+ P S P P + + +P+ A CS+PS A
Sbjct: 1920 PSLQKDGAKEPER------KEQPLQRHPSSIPPPPLTAKDLSSPA-ARQHCSSPSHASGR 1972
Query: 1527 VPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKKGVSSPAPPGP 1570
P G KP S P + P + S PGP
Sbjct: 1973 EP-------GAKPSTAEPSSSPQDPPKPVAAHSESSSHKPRPGP 2009
Score = 35.8 bits (81), Expect = 0.33
Identities = 116/507 (22%), Positives = 175/507 (34%), Gaps = 106/507 (20%)
Query: 1111 LSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRSTPDSAYLGASSQSSSPASSTPNSPASS 1170
++ L+ +S LP + P SP+ R++ +S + + S+ SP+S
Sbjct: 1618 IALLSGPQASKTELPSPESAQSP--SPSGDVRASVPPVLPSSSGKKNDTTSARELSPSS- 1674
Query: 1171 ASHHIRPSTLHGLSPKLHRQYRSARCKSAGNIPLSPLAHT---PSPTQASPPPL----PG 1223
++ + + L P R + A ++P P PT SP + P
Sbjct: 1675 ----LKMNKSYLLEPWFLPPSRGLQNSPAVSLPDPEFKRDRKGPHPTARSPGTVMESNPQ 1730
Query: 1224 HTVGSS-----HTTQS-----FPAKLHSSPPVVRPR---PKSAEPPRS-PLLKRVQSAEK 1269
GSS HTT LHS P + RPR P A P R P L+ +S+E+
Sbjct: 1731 QREGSSPKHQDHTTDPKLLTCLGQNLHS-PDLARPRCPLPPEASPSREKPGLR--ESSER 1787
Query: 1270 ----LGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGLGAPRQ 1325
+ SA + R+ S+E+ P+ K L S+ G T P
Sbjct: 1788 GPPTARSERSAARADTCREPSMELCFPETAKTSDNSKNLLSV----GRTHP--------- 1834
Query: 1326 VAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTP---GGRTL 1382
E A P + K+ PG EA PPR + G
Sbjct: 1835 -------------DFYTQTQAMEKAWAPGGKTNHKDGPG--EARPPPRDNSSLHSAGIPC 1879
Query: 1383 ERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEPAR 1442
E+++G R + V+ + R++ + + + S + G +P +
Sbjct: 1880 EKELGKVR-RGVEPKPEALLARRSLQPPGIESEKSEKLSSFPSLQKDGAKEPERKEQPLQ 1938
Query: 1443 PGAKAVVPQPLGADSKGLQEPAPLAP-SVPEAPRGRERWVLEVVEERTTLSGPRSKPASP 1501
++ P PL A K L PA S P GRE P +KP++
Sbjct: 1939 RHPSSIPPPPLTA--KDLSSPAARQHCSSPSHASGRE---------------PGAKPSTA 1981
Query: 1502 KLSPEPQTP-----------SLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAE 1550
+ S PQ P S P P T P SL S KP VG T
Sbjct: 1982 EPSSSPQDPPKPVAAHSESSSHKPRPGPDPGPPKTKHPDRSL--SSQKPSVGATKGKEPA 2039
Query: 1551 AVPPAGLTKKGVSS--------PAPPG 1569
G +++G PA PG
Sbjct: 2040 TQSLGGSSREGKGHSKSGPDVFPATPG 2066
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 1421 bits (3679), Expect = 0.0
Identities = 804/1357 (59%), Positives = 958/1357 (70%), Gaps = 105/1357 (7%)
Query: 21 SMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLP-GHLGSSPLDSPRNFSPNTPAHFSFA 79
S+ RR + CR+ NRKSL++ + SPTL RP SPL GSSPLDSPRNFS + +F FA
Sbjct: 17 SLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLDSPRNFSAASALNFPFA 76
Query: 80 SSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGS 139
RRADGRRWSLASLPSSGYGTNTPSST+SSS SS+ERLHQLP+QPT DELHFLSKHF S
Sbjct: 77 --RRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQPTPDELHFLSKHFRS 134
Query: 140 TESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRD 199
+E++ DE+GGR SP +RPRSRSLSPGR+ ++DNEIVMMNHVY+ERFPKATAQME +L++
Sbjct: 135 SENVLDEEGGR-SPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERFPKATAQMEGRLQE 193
Query: 200 FTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDA 259
F AY P + L LADGVL FIHHQI+ELARDCL KS + L+T+ YF E+QE LE+LLQDA
Sbjct: 194 FLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFLEMQEKLERLLQDA 253
Query: 260 YERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTD 319
+ERS+S EV+F+ QLV+KLLIIISRPARLLECLEF+PEEFYHLLEAAEGHA+EG +KTD
Sbjct: 254 HERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAAEGHAREGQGIKTD 313
Query: 320 IPRYIIRQLGLTRDPFPDVV---HLEEQDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDT 376
+P+YII QLGL +DP ++V HLEE+ +PE S ++++ P E+DF+T
Sbjct: 314 LPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPE----SRALVGQSRRKPCESDFET 369
Query: 377 IKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVG 436
IKLISNGAYGAVYLVRHRDTRQRFA+KKINKQNLILRNQIQQ FVERDILTFAENPFVV
Sbjct: 370 IKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVS 429
Query: 437 MFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHR 496
MFCSFETRRHLCMVMEYVEGGDCATLLKN+G LPV+MAR+YFAETVLALEYLHNYGIVHR
Sbjct: 430 MFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHR 489
Query: 497 DLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAP 556
DLKPDNLLITS+GHIKLTDFGLSK+GLMS+ TNLYEGHIEKDAREF+DKQVCGTPEYIAP
Sbjct: 490 DLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAP 549
Query: 557 EVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTE 616
EVI RQGYGKPVDWWAMG++LYEFLVGCVPFFGDTPEELFGQV+SD+I+WPEGDEALP +
Sbjct: 550 EVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPAD 609
Query: 617 AQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFD 676
AQ LI+ LL+ +PL RLG GG EVKQH FF LDW GLLR KAEF+P LE+EDDTSYFD
Sbjct: 610 AQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFD 669
Query: 677 TRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVAAAGSS 736
TRS+RY H+ S D++ EE EI QFSSCS RFSKVYSS E L+ T + S
Sbjct: 670 TRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTPTFAERSFSE 729
Query: 737 KREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARR 796
RE + E G+R +R ++W S+ ++S + E P
Sbjct: 730 DREEGWERSEVDY-GRRL---SADIRLRSWTSSG------SSCQSSSSQPERGPSPSLLN 779
Query: 797 RFSALLEPSRFSAPQEDE----DEARLRRP--------PRPSSDPA----GSLDARAPKE 840
S P +F+ EDE A +RP P P++ P SL A
Sbjct: 780 TISLDTMP-KFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAAL 838
Query: 841 ETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEK 900
++S G +T PRP D + GPR D ++R G
Sbjct: 839 SHARLRSNSIGARHST--PRPLD---AGRGRRLGGPR---DPAPEKSRASSSGGS----- 885
Query: 901 RPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPA 960
+GG+V KSAS +ALS++I A D G PL SP+SPRSLSSNPSSRDSSPSRD SP
Sbjct: 886 -GGGSGGRVPKSASVSALSLIITADDGSG-GPLMSPLSPRSLSSNPSSRDSSPSRDPSPV 943
Query: 961 VSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLI 1020
LR PI I SGKKYGF+LRAIRVYMGD+DVY+VHH+VW VE+G PAQEAGL AGDLI
Sbjct: 944 CGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLI 1003
Query: 1021 THVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRP 1080
TH+NGE V G+VH +VVEL+LKSGNK+++ TT ENTSI++GPAR++ K +MARR+KR
Sbjct: 1004 THINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRS 1063
Query: 1081 SAKEGQESKKRSSLFRKITKQSNLLHTSRSLSS-LNRSLSSSDSLPGSPTHGLPARSPTH 1139
+E Q+ +R SLF+KI+KQ+++LHTSRS SS L+ SLSSS+SLPGSPTH L + SPT
Sbjct: 1064 RRRETQD--RRKSLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSL-SPSPTT 1120
Query: 1140 SYRS-TPD-SAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKL-HRQYRSARC 1196
RS PD A AS S+SP+SS+P SPA A+ H RPS+LHGL+ KL + ++ R
Sbjct: 1121 PCRSPAPDVPADTTASPPSASPSSSSPASPA--AAGHTRPSSLHGLAAKLGPPRPKTGRR 1178
Query: 1197 KSAGNIPLSPLAHTP--SPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAE 1254
KS +IP SPLA P +P SP PLPGH PP
Sbjct: 1179 KSTSSIPPSPLACPPISAPPPRSPSPLPGH------------------PPA--------- 1211
Query: 1255 PPRSPLLKRVQSAEKLGASLSADKKGALRKHSLEVG-------HPDFRKDFHGELALHSL 1307
P RSP L+R QSA+KLG D + R E H R+D + ++
Sbjct: 1212 PARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERRDSFKK--QEAV 1269
Query: 1308 AESDGETPPVEGLGAPR---QVAVRRLGRQESPLSLG 1341
E + P E G P Q+AV G + P++LG
Sbjct: 1270 QEVSFDEPQEEATGLPTSVPQIAVE--GEEAVPVALG 1304
Score = 37.4 bits (85), Expect = 0.11
Identities = 33/104 (31%), Positives = 46/104 (44%), Gaps = 23/104 (22%)
Query: 1490 TLSGPRSKPASP--KLSPEPQTPSLAPAK-------CSAPSSAVTPVPPASLLGSG-TKP 1539
+LS S P SP LSP P TP +PA S PS++ + PAS +G T+P
Sbjct: 1099 SLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSASPSSSSPASPAAAGHTRP 1158
Query: 1540 QV--GLTS-----------RCPAEAVPPAGLTKKGVSSPAPPGP 1570
GL + R ++PP+ L +S+P P P
Sbjct: 1159 SSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPRSP 1202
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 230 bits (586), Expect = 9e-60
Identities = 135/377 (35%), Positives = 202/377 (53%), Gaps = 35/377 (9%)
Query: 332 RDPFPDVVHLEEQDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLV 391
R P D + + S+T E+ +++ SKA+ NDFD +KL+ G +G V LV
Sbjct: 113 RAPGEDPMDYKCGSPSDSSTTEEMEVAV---SKARAKVTMNDFDYLKLLGKGTFGKVILV 169
Query: 392 RHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVM 451
R + T + +AMK + K+ +I ++++ E +L +PF+ + +F+T LC VM
Sbjct: 170 REKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVM 229
Query: 452 EYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHI 511
EY GG+ L E AR Y AE V ALEYLH+ +V+RD+K +NL++ GHI
Sbjct: 230 EYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHI 289
Query: 512 KLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWW 571
K+TDFGL K G+ T K CGTPEY+APEV+ YG+ VDWW
Sbjct: 290 KITDFGLCKEGISDGATM---------------KTFCGTPEYLAPEVLEDNDYGRAVDWW 334
Query: 572 AMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLV 631
+G+++YE + G +PF+ E LF ++ ++I +P L EA+ L++ LL+ +P
Sbjct: 335 GLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFP---RTLSPEAKSLLAGLLKKDPKQ 391
Query: 632 RLGAG--GAFEVKQHSFFRDLDWTGLLRQK--AEFIPHLESEDDTSYFD----------T 677
RLG G A EV +H FF ++W ++++K F P + SE DT YFD T
Sbjct: 392 RLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITIT 451
Query: 678 RSDRYHHVNSYDEDDTT 694
DRY + + D T
Sbjct: 452 PPDRYDSLGLLELDQRT 468
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 228 bits (581), Expect = 4e-59
Identities = 129/342 (37%), Positives = 191/342 (55%), Gaps = 25/342 (7%)
Query: 342 EEQDSGGSNTPEQDDLSEGR---SSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQ 398
EE+ S T + D++ E S+ K NDFD +KL+ G +G V LVR + + +
Sbjct: 113 EEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGK 172
Query: 399 RFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGD 458
+AMK + K+ +I ++++ E +L +PF+ + SF+T+ LC VMEYV GG+
Sbjct: 173 YYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGE 232
Query: 459 CATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGL 518
L + R Y AE V AL+YLH+ IV+RDLK +NL++ GHIK+TDFGL
Sbjct: 233 LFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL 292
Query: 519 SKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILY 578
K G+ T K CGTPEY+APEV+ YG+ VDWW +G+++Y
Sbjct: 293 CKEGITDAATM---------------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMY 337
Query: 579 EFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAG-- 636
E + G +PF+ E+LF ++ +DI +P L ++A+ L+S LL +P RLG G
Sbjct: 338 EMMCGRLPFYNQDHEKLFELILMEDIKFP---RTLSSDAKSLLSGLLIKDPNKRLGGGPD 394
Query: 637 GAFEVKQHSFFRDLDWTGLLRQK--AEFIPHLESEDDTSYFD 676
A E+ +HSFF ++W + +K F P + SE DT YFD
Sbjct: 395 DAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFD 436
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 228 bits (581), Expect = 4e-59
Identities = 129/342 (37%), Positives = 191/342 (55%), Gaps = 25/342 (7%)
Query: 342 EEQDSGGSNTPEQDDLSEGR---SSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQ 398
EE+ S T + D++ E S+ K NDFD +KL+ G +G V LVR + + +
Sbjct: 113 EEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGK 172
Query: 399 RFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGD 458
+AMK + K+ +I ++++ E +L +PF+ + SF+T+ LC VMEYV GG+
Sbjct: 173 YYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGE 232
Query: 459 CATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGL 518
L + R Y AE V AL+YLH+ IV+RDLK +NL++ GHIK+TDFGL
Sbjct: 233 LFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGL 292
Query: 519 SKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILY 578
K G+ T K CGTPEY+APEV+ YG+ VDWW +G+++Y
Sbjct: 293 CKEGITDAATM---------------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMY 337
Query: 579 EFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAG-- 636
E + G +PF+ E+LF ++ +DI +P L ++A+ L+S LL +P RLG G
Sbjct: 338 EMMCGRLPFYNQDHEKLFELILMEDIKFP---RTLSSDAKSLLSGLLIKDPNKRLGGGPD 394
Query: 637 GAFEVKQHSFFRDLDWTGLLRQK--AEFIPHLESEDDTSYFD 676
A E+ +HSFF ++W + +K F P + SE DT YFD
Sbjct: 395 DAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFD 436
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 223 bits (569), Expect = 9e-58
Identities = 132/341 (38%), Positives = 197/341 (57%), Gaps = 44/341 (12%)
Query: 373 DFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 432
D++ +K+I GA+G V LVRH+ TR+ +AMK ++K +I R+ + ERDI+ FA +P
Sbjct: 75 DYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 134
Query: 433 FVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYG 492
+VV +F +F+ R+L MVMEY+ GGD L+ N +P + AR Y AE VLAL+ +H+ G
Sbjct: 135 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSMG 193
Query: 493 IVHRDLKPDNLLITSMGHIKLTDFG----LSKMGLMSLTTNLYEGHIEKDAREFLDKQVC 548
+HRD+KPDN+L+ GH+KL DFG ++K G++ T
Sbjct: 194 FIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDT------------------AV 235
Query: 549 GTPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS--D 602
GTP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + ++++ +
Sbjct: 236 GTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKN 295
Query: 603 DILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWT--GLLRQKA 660
+ +P+ D + EA+ LI + L T+ VRLG G E+K+H FF++ W L A
Sbjct: 296 SLTFPD-DNDISKEAKNLICAFL-TDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVA 353
Query: 661 EFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEI 701
+P L S+ DTS FD E+D EEE I
Sbjct: 354 PVVPDLSSDIDTSNFDDL-----------EEDKGEEETFPI 383
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 222 bits (565), Expect = 3e-57
Identities = 125/364 (34%), Positives = 193/364 (53%), Gaps = 41/364 (11%)
Query: 354 QDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILR 413
++D + S A+ + F+ IK + G++G V LV+H++T +AMK ++KQ ++
Sbjct: 16 KEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKL 75
Query: 414 NQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEM 473
QI+ E+ IL PF+V + SF+ +L MVMEYV GG+ + L+ IG
Sbjct: 76 KQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 135
Query: 474 ARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEG 533
AR Y A+ VL EYLH+ +++RDLKP+NLLI G+I++TDFG +K T
Sbjct: 136 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT----- 190
Query: 534 HIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPE 593
+CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P
Sbjct: 191 -------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 237
Query: 594 ELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLG--AGGAFEVKQHSFFRDLD 651
+++ +++S + +P ++ + L+ +LLQ + R G G ++K H +F D
Sbjct: 238 QIYEKIVSGKVRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 294
Query: 652 WTGLLRQKAE--FIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSP 709
W + ++K E FIP + DTS F D EEE + + C
Sbjct: 295 WIAIYQRKVEAPFIPKFKGPGDTSNF----------------DDYEEEEIRVSINEKCGK 338
Query: 710 RFSK 713
FS+
Sbjct: 339 EFSE 342
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 222 bits (565), Expect = 3e-57
Identities = 125/364 (34%), Positives = 193/364 (53%), Gaps = 41/364 (11%)
Query: 354 QDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILR 413
++D + S A+ + F+ IK + G++G V LV+H++T +AMK ++KQ ++
Sbjct: 24 KEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKL 83
Query: 414 NQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEM 473
QI+ E+ IL PF+V + SF+ +L MVMEYV GG+ + L+ IG
Sbjct: 84 KQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 474 ARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEG 533
AR Y A+ VL EYLH+ +++RDLKP+NLLI G+I++TDFG +K T
Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT----- 198
Query: 534 HIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPE 593
+CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P
Sbjct: 199 -------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 245
Query: 594 ELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLG--AGGAFEVKQHSFFRDLD 651
+++ +++S + +P ++ + L+ +LLQ + R G G ++K H +F D
Sbjct: 246 QIYEKIVSGKVRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302
Query: 652 WTGLLRQKAE--FIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSP 709
W + ++K E FIP + DTS F D EEE + + C
Sbjct: 303 WIAIYQRKVEAPFIPKFKGPGDTSNF----------------DDYEEEEIRVSINEKCGK 346
Query: 710 RFSK 713
FS+
Sbjct: 347 EFSE 350
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 221 bits (564), Expect = 3e-57
Identities = 128/363 (35%), Positives = 196/363 (53%), Gaps = 27/363 (7%)
Query: 342 EEQDSGGSNTPEQDDLSEGRSSKAKKPPGE---NDFDTIKLISNGAYGAVYLVRHRDTRQ 398
EE+ S +P + +E KP N+F+ +KL+ G +G V LV+ + T +
Sbjct: 115 EEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR 174
Query: 399 RFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGD 458
+AMK + K+ ++ ++++ E +L + +PF+ + SF+T LC VMEY GG+
Sbjct: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGE 234
Query: 459 CATLLKNIGALPVEMARMYFAETVLALEYLHN-YGIVHRDLKPDNLLITSMGHIKLTDFG 517
L + AR Y AE V AL+YLH+ +V+RDLK +NL++ GHIK+TDFG
Sbjct: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294
Query: 518 LSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIIL 577
L K G+ T K CGTPEY+APEV+ YG+ VDWW +G+++
Sbjct: 295 LCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVM 339
Query: 578 YEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGG 637
YE + G +PF+ E+LF ++ ++I +P L EA+ L+S LL+ +P RLG G
Sbjct: 340 YEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLKKDPKQRLGGGS 396
Query: 638 --AFEVKQHSFFRDLDWTGLLRQKAE--FIPHLESEDDTSYFDTR-SDRYHHVNSYDEDD 692
A E+ QH FF + W + +K F P + SE DT YFD + + + D+DD
Sbjct: 397 EDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDD 456
Query: 693 TTE 695
+ E
Sbjct: 457 SME 459
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 221 bits (564), Expect = 3e-57
Identities = 128/363 (35%), Positives = 196/363 (53%), Gaps = 27/363 (7%)
Query: 342 EEQDSGGSNTPEQDDLSEGRSSKAKKPPGE---NDFDTIKLISNGAYGAVYLVRHRDTRQ 398
EE+ S +P + +E KP N+F+ +KL+ G +G V LV+ + T +
Sbjct: 115 EEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR 174
Query: 399 RFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGD 458
+AMK + K+ ++ ++++ E +L + +PF+ + SF+T LC VMEY GG+
Sbjct: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGE 234
Query: 459 CATLLKNIGALPVEMARMYFAETVLALEYLHN-YGIVHRDLKPDNLLITSMGHIKLTDFG 517
L + AR Y AE V AL+YLH+ +V+RDLK +NL++ GHIK+TDFG
Sbjct: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294
Query: 518 LSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIIL 577
L K G+ T K CGTPEY+APEV+ YG+ VDWW +G+++
Sbjct: 295 LCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVM 339
Query: 578 YEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGG 637
YE + G +PF+ E+LF ++ ++I +P L EA+ L+S LL+ +P RLG G
Sbjct: 340 YEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLKKDPKQRLGGGS 396
Query: 638 --AFEVKQHSFFRDLDWTGLLRQKAE--FIPHLESEDDTSYFDTR-SDRYHHVNSYDEDD 692
A E+ QH FF + W + +K F P + SE DT YFD + + + D+DD
Sbjct: 397 EDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDD 456
Query: 693 TTE 695
+ E
Sbjct: 457 SME 459
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 221 bits (564), Expect = 3e-57
Identities = 128/363 (35%), Positives = 196/363 (53%), Gaps = 27/363 (7%)
Query: 342 EEQDSGGSNTPEQDDLSEGRSSKAKKPPGE---NDFDTIKLISNGAYGAVYLVRHRDTRQ 398
EE+ S +P + +E KP N+F+ +KL+ G +G V LV+ + T +
Sbjct: 115 EEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGR 174
Query: 399 RFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGD 458
+AMK + K+ ++ ++++ E +L + +PF+ + SF+T LC VMEY GG+
Sbjct: 175 YYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGE 234
Query: 459 CATLLKNIGALPVEMARMYFAETVLALEYLHN-YGIVHRDLKPDNLLITSMGHIKLTDFG 517
L + AR Y AE V AL+YLH+ +V+RDLK +NL++ GHIK+TDFG
Sbjct: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294
Query: 518 LSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIIL 577
L K G+ T K CGTPEY+APEV+ YG+ VDWW +G+++
Sbjct: 295 LCKEGIKDGATM---------------KTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVM 339
Query: 578 YEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGG 637
YE + G +PF+ E+LF ++ ++I +P L EA+ L+S LL+ +P RLG G
Sbjct: 340 YEMMCGRLPFYNQDHEKLFELILMEEIRFP---RTLGPEAKSLLSGLLKKDPKQRLGGGS 396
Query: 638 --AFEVKQHSFFRDLDWTGLLRQKAE--FIPHLESEDDTSYFDTR-SDRYHHVNSYDEDD 692
A E+ QH FF + W + +K F P + SE DT YFD + + + D+DD
Sbjct: 397 EDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDD 456
Query: 693 TTE 695
+ E
Sbjct: 457 SME 459
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 221 bits (564), Expect = 3e-57
Identities = 119/329 (36%), Positives = 185/329 (56%), Gaps = 24/329 (7%)
Query: 370 GENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 429
G +DF+++K+I GA+G V LV+ +DT +AMK + K +++ + Q+ ERDIL A
Sbjct: 86 GLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEA 145
Query: 430 ENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLH 489
+ +VV MF SF+ +R+L ++ME++ GGD TLL L E + Y +ETVLA++ +H
Sbjct: 146 DGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIH 205
Query: 490 NYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLY------------------ 531
G +HRD+KPDNLL+ + GH+KL+DFGL + T Y
Sbjct: 206 QLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNS 265
Query: 532 --EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG 589
+ K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF
Sbjct: 266 KRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS 325
Query: 590 DTPEELFGQVIS--DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFF 647
+TP+E + +V++ + +++P L++ + + R+G G E+K H FF
Sbjct: 326 ETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSEN--RIGNSGVEEIKGHPFF 383
Query: 648 RDLDWTGLLRQKAEFIPHLESEDDTSYFD 676
+DW + + A ++S DDTS FD
Sbjct: 384 EGVDWEHIRERPAAIPIEIKSIDDTSNFD 412
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 219 bits (559), Expect = 1e-56
Identities = 121/343 (35%), Positives = 187/343 (54%), Gaps = 35/343 (10%)
Query: 354 QDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILR 413
++D + + + G DF+ K + G++G V LV+H+ T Q +AMK ++KQ ++
Sbjct: 24 KEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKL 83
Query: 414 NQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEM 473
QI+ E+ IL PF+V + +F+ +L MVMEYV GG+ + L+ IG
Sbjct: 84 KQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 143
Query: 474 ARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEG 533
AR Y A+ VL EYLH+ +++RDLKP+NLLI G+I++TDFG +K T
Sbjct: 144 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWT----- 198
Query: 534 HIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPE 593
+CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P
Sbjct: 199 -------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 245
Query: 594 ELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLG--AGGAFEVKQHSFFRDLD 651
+++ +++S + +P ++ + L+ +LLQ + R G G ++K H +F D
Sbjct: 246 QIYEKIVSGKVRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 302
Query: 652 WTGLLRQKAE--FIPHLESEDDTSYFDTRSDRYHHVNSYDEDD 692
W + ++K E FIP DTS FD Y+E+D
Sbjct: 303 WIAIYQRKVEAPFIPKFRGSGDTSNFD----------DYEEED 335
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 219 bits (559), Expect = 1e-56
Identities = 121/343 (35%), Positives = 187/343 (54%), Gaps = 35/343 (10%)
Query: 354 QDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILR 413
++D + + + G DF+ K + G++G V LV+H+ T Q +AMK ++KQ ++
Sbjct: 71 KEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKL 130
Query: 414 NQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEM 473
QI+ E+ IL PF+V + +F+ +L MVMEYV GG+ + L+ IG
Sbjct: 131 KQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPH 190
Query: 474 ARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEG 533
AR Y A+ VL EYLH+ +++RDLKP+NLLI G+I++TDFG +K T
Sbjct: 191 ARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWT----- 245
Query: 534 HIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPE 593
+CGTPEY+APE+IL +GY K VDWWA+G+++YE G PFF D P
Sbjct: 246 -------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPI 292
Query: 594 ELFGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLG--AGGAFEVKQHSFFRDLD 651
+++ +++S + +P ++ + L+ +LLQ + R G G ++K H +F D
Sbjct: 293 QIYEKIVSGKVRFP---SHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 349
Query: 652 WTGLLRQKAE--FIPHLESEDDTSYFDTRSDRYHHVNSYDEDD 692
W + ++K E FIP DTS FD Y+E+D
Sbjct: 350 WIAIYQRKVEAPFIPKFRGSGDTSNFD----------DYEEED 382
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 219 bits (558), Expect = 2e-56
Identities = 123/328 (37%), Positives = 192/328 (58%), Gaps = 33/328 (10%)
Query: 373 DFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENP 432
D+D +K+I GA+G V LVRH+ +++ +AMK ++K +I R+ + ERDI+ FA +P
Sbjct: 91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 150
Query: 433 FVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYG 492
+VV +F +F+ R+L MVMEY+ GGD L+ N +P + A+ Y AE VLAL+ +H+ G
Sbjct: 151 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHSMG 209
Query: 493 IVHRDLKPDNLLITSMGHIKLTDFG----LSKMGLMSLTTNLYEGHIEKDAREFLDKQVC 548
++HRD+KPDN+L+ GH+KL DFG + + G++ T
Sbjct: 210 LIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDT------------------AV 251
Query: 549 GTPEYIAPEVILRQG----YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--SD 602
GTP+YI+PEV+ QG YG+ DWW++G+ LYE LVG PF+ D+ + +++ +
Sbjct: 252 GTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKN 311
Query: 603 DILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRD--LDWTGLLRQKA 660
+ +PE D + A+ LI + L T+ VRLG G E++QH FF++ W + A
Sbjct: 312 SLCFPE-DAEISKHAKNLICAFL-TDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAA 369
Query: 661 EFIPHLESEDDTSYFDTRSDRYHHVNSY 688
+P L S+ D+S FD D V ++
Sbjct: 370 PVVPELSSDIDSSNFDDIEDDKGDVETF 397
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 218 bits (556), Expect = 3e-56
Identities = 121/329 (36%), Positives = 184/329 (55%), Gaps = 24/329 (7%)
Query: 370 GENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 429
G DF+++K+I GA+G V LV+ +DT +AMK + K +++ + Q+ ERDIL A
Sbjct: 85 GLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEA 144
Query: 430 ENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLH 489
++ +VV MF SF+ + +L ++ME++ GGD TLL L E + Y AETVLA++ +H
Sbjct: 145 DSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIH 204
Query: 490 NYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLY------------------ 531
G +HRD+KPDNLL+ S GH+KL+DFGL + T Y
Sbjct: 205 QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 264
Query: 532 --EGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG 589
+ K R L GTP+YIAPEV ++ GY K DWW++G+I+YE L+G PF
Sbjct: 265 KRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS 324
Query: 590 DTPEELFGQVIS--DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFF 647
+TP+E + +V++ + + +P L++ + R+GA G E+K +SFF
Sbjct: 325 ETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEH--RIGAPGVEEIKSNSFF 382
Query: 648 RDLDWTGLLRQKAEFIPHLESEDDTSYFD 676
+DW + + A ++S DDTS FD
Sbjct: 383 EGVDWEHIRERPAAISIEIKSIDDTSNFD 411
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 218 bits (554), Expect = 5e-56
Identities = 132/365 (36%), Positives = 199/365 (54%), Gaps = 28/365 (7%)
Query: 320 IPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDTIKL 379
+PR ++ T P P ++DS E ++ K P F+ +K+
Sbjct: 19 LPRKQRPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPSH--FELLKV 76
Query: 380 ISNGAYGAVYLVR---HRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVG 436
+ G++G V+LVR D+ +AMK + K L +R++++ +ERDIL +PFVV
Sbjct: 77 LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK-MERDILADVNHPFVVK 135
Query: 437 MFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHR 496
+ +F+T L ++++++ GGD T L E + Y AE L L++LH+ GI++R
Sbjct: 136 LHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYR 195
Query: 497 DLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAP 556
DLKP+N+L+ GHIKLTDFGLSK + EK A F CGT EY+AP
Sbjct: 196 DLKPENILLDEEGHIKLTDFGLSKEAI----------DHEKKAYSF-----CGTVEYMAP 240
Query: 557 EVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTE 616
EV+ RQG+ DWW+ G++++E L G +PF G +E ++ + P + L TE
Sbjct: 241 EVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP---QFLSTE 297
Query: 617 AQLLISSLLQTNPLVRLGAG--GAFEVKQHSFFRDLDWTGLLRQ--KAEFIPHLESEDDT 672
AQ L+ +L + NP RLG+G GA E+K+H F+ +DW L R+ K F P + DDT
Sbjct: 298 AQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDT 357
Query: 673 SYFDT 677
YFDT
Sbjct: 358 FYFDT 362
Score = 105 bits (261), Expect = 4e-22
Identities = 83/316 (26%), Positives = 140/316 (44%), Gaps = 32/316 (10%)
Query: 344 QDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMK 403
+D G P+ S + K + + + I G+Y H+ T +A+K
Sbjct: 397 EDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVK 456
Query: 404 KINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLL 463
I+K +I+ +L + ++P ++ + ++ +H+ +V E + GG+ +
Sbjct: 457 VIDKSKRDPSEEIEI------LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKI 510
Query: 464 KNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLL-ITSMGH---IKLTDFGLS 519
A +EYLH+ G+VHRDLKP N+L + G+ +++ DFG +
Sbjct: 511 LRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFA 570
Query: 520 KMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYE 579
K + A L C T ++APEV+ RQGY + D W++GI+LY
Sbjct: 571 K---------------QLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYT 615
Query: 580 FLVGCVPFF---GDTPEELFGQVISDDILWPEGD-EALPTEAQLLISSLLQTNPLVRLGA 635
L G PF DTPEE+ ++ S G+ + A+ L+S +L +P RL A
Sbjct: 616 MLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTA 675
Query: 636 GGAFEVKQHSFFRDLD 651
+V QH + D
Sbjct: 676 K---QVLQHPWVTQKD 688
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 217 bits (552), Expect = 8e-56
Identities = 120/353 (33%), Positives = 189/353 (53%), Gaps = 41/353 (11%)
Query: 365 AKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERD 424
A+ + F+ ++ + G++G V LVRH++T +AMK +NKQ ++ Q++ E+
Sbjct: 35 AQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKR 94
Query: 425 ILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLA 484
IL + PF+V + SF+ +L +VMEYV GG+ + L+ +G A Y A+ VLA
Sbjct: 95 ILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLA 154
Query: 485 LEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLD 544
++YLH+ ++HRDLKP+NLLI G++++TDFG +K T
Sbjct: 155 VQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWT---------------- 198
Query: 545 KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDI 604
+CGTPEY+APE+IL +GY K VDWWA+G+++YE VG PF+ D P +++ +++S +
Sbjct: 199 --LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRV 256
Query: 605 LWPEGDEALPTEAQLLISSLLQTNPLVRLG--AGGAFEVKQHSFFRDLDWTGLLRQKAE- 661
+P L ++ + L+ SLLQ + R G G ++K H +F W + +K E
Sbjct: 257 RFP---SKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEA 313
Query: 662 -FIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSK 713
FIP D S F D EEE + I C+ FS+
Sbjct: 314 PFIPKYTGPGDASNF----------------DDYEEEELRISINEKCAKEFSE 350
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 216 bits (550), Expect = 1e-55
Identities = 122/311 (39%), Positives = 182/311 (58%), Gaps = 26/311 (8%)
Query: 374 FDTIKLISNGAYGAVYLVR---HRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAE 430
F+ +K++ G++G V+LVR D+ +AMK + K L +R++++ +ERDIL
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK-MERDILADVN 120
Query: 431 NPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHN 490
+PFVV + +F+T L ++++++ GGD T L E + Y AE L L++LH+
Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHS 180
Query: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550
GI++RDLKP+N+L+ GHIKLTDFGLSK + EK A F CGT
Sbjct: 181 LGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI----------DHEKKAYSF-----CGT 225
Query: 551 PEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGD 610
EY+APEV+ RQG+ DWW+ G++++E L G +PF G +E ++ + P
Sbjct: 226 VEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP--- 282
Query: 611 EALPTEAQLLISSLLQTNPLVRLGAG--GAFEVKQHSFFRDLDWTGLLRQ--KAEFIPHL 666
+ L TEAQ L+ +L + NP RLG+G GA E+K+H F+ +DW L R+ K F P +
Sbjct: 283 QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAV 342
Query: 667 ESEDDTSYFDT 677
DDT YFDT
Sbjct: 343 AQPDDTFYFDT 353
Score = 105 bits (261), Expect = 4e-22
Identities = 83/316 (26%), Positives = 140/316 (44%), Gaps = 32/316 (10%)
Query: 344 QDSGGSNTPEQDDLSEGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMK 403
+D G P+ S + K + + + I G+Y H+ T +A+K
Sbjct: 388 EDDGKPRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVK 447
Query: 404 KINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLL 463
I+K +I+ +L + ++P ++ + ++ +H+ +V E + GG+ +
Sbjct: 448 VIDKSKRDPSEEIEI------LLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKI 501
Query: 464 KNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLL-ITSMGH---IKLTDFGLS 519
A +EYLH+ G+VHRDLKP N+L + G+ +++ DFG +
Sbjct: 502 LRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFA 561
Query: 520 KMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYE 579
K + A L C T ++APEV+ RQGY + D W++GI+LY
Sbjct: 562 K---------------QLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYT 606
Query: 580 FLVGCVPFF---GDTPEELFGQVISDDILWPEGD-EALPTEAQLLISSLLQTNPLVRLGA 635
L G PF DTPEE+ ++ S G+ + A+ L+S +L +P RL A
Sbjct: 607 MLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTA 666
Query: 636 GGAFEVKQHSFFRDLD 651
+V QH + D
Sbjct: 667 K---QVLQHPWVTQKD 679
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 215 bits (548), Expect = 2e-55
Identities = 128/369 (34%), Positives = 198/369 (53%), Gaps = 46/369 (12%)
Query: 359 EGRSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQ 418
E R S+ + DF ++ G +G V L +++T + FA+K + K +++ R+++
Sbjct: 642 EDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDS 701
Query: 419 AFVERDI---LTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMAR 475
E+ I + +PF+V +F F+T+ H+C VMEY GGD + + A
Sbjct: 702 LMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHI-HTDVFSEPRAV 760
Query: 476 MYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHI 535
Y A VL L+YLH + IV+RDLK DNLL+ + G +K+ DFGL K G+ G+
Sbjct: 761 FYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGM---------GYG 811
Query: 536 EKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEEL 595
++ + CGTPE++APEV+ Y + VDWW +G+++YE LVG PF GD EE+
Sbjct: 812 DRTST------FCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEV 865
Query: 596 FGQVISDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAG--GAFEVKQHSFFRDLDWT 653
F +++D++ +P L TEA ++ LL+ NP RLGA A +VK+H FFR +DW+
Sbjct: 866 FDSIVNDEVRYP---RFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWS 922
Query: 654 GLLRQKAE--FIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRF 711
L+ +K + FIP + +D S FD D+ T E P+ PR
Sbjct: 923 ALMDKKVKPPFIPTIRGREDVSNFD--------------DEFTSEAPI------LTPPRE 962
Query: 712 SKVYSSMEQ 720
++ S EQ
Sbjct: 963 PRILSEEEQ 971
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 214 bits (546), Expect = 4e-55
Identities = 157/510 (30%), Positives = 231/510 (45%), Gaps = 48/510 (9%)
Query: 372 NDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 431
+DF+ +K+I GA+ V +V+ + T Q +AMK +NK +++ R ++ ERD+L +
Sbjct: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
Query: 432 PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGA-LPVEMARMYFAETVLALEYLHN 490
++ + +F+ +L +VMEY GGD TLL G +P EMAR Y AE V+A++ +H
Sbjct: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
Query: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550
G VHRD+KPDN+L+ GHI+L DFG + + + R + GT
Sbjct: 189 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 234
Query: 551 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 601
P+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
Query: 602 DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAE 661
+ + P DE +P EA+ I LL P RLG GGA + + H FF LDW GL
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
Query: 662 FIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQL 721
F P E DT FD D + + D E P+ + P YS M
Sbjct: 354 FTPDFEGATDTCNFDLVEDGLTAMETL--SDIREGAPLGVH-----LPFVGYSYSCMALR 406
Query: 722 SQHEP-KTPVAAAGSSKREPSTKGP--EEKVAGKREGLGGLTLREKTWRGGSPEIKRFSA 778
P TP+ EP + P E V+ + E E+
Sbjct: 407 DSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLREL 466
Query: 779 SEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAP 838
EA LE E R A+ ++ A Q E EAR R L+A
Sbjct: 467 QEA--LEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNR-----------DLEAHVR 513
Query: 839 KEETQGEGTSSAGDSEATDRPRPGDLCPPS 868
+ + + E + G + T P P PPS
Sbjct: 514 QLQERMELLQAEGATAVTGVPSPRATDPPS 543
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 214 bits (546), Expect = 4e-55
Identities = 157/510 (30%), Positives = 231/510 (45%), Gaps = 48/510 (9%)
Query: 372 NDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 431
+DF+ +K+I GA+ V +V+ + T Q +AMK +NK +++ R ++ ERD+L +
Sbjct: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
Query: 432 PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGA-LPVEMARMYFAETVLALEYLHN 490
++ + +F+ +L +VMEY GGD TLL G +P EMAR Y AE V+A++ +H
Sbjct: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
Query: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550
G VHRD+KPDN+L+ GHI+L DFG + + + R + GT
Sbjct: 189 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 234
Query: 551 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 601
P+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
Query: 602 DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAE 661
+ + P DE +P EA+ I LL P RLG GGA + + H FF LDW GL
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
Query: 662 FIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQL 721
F P E DT FD D + + D E P+ + P YS M
Sbjct: 354 FTPDFEGATDTCNFDLVEDGLTAMETL--SDIREGAPLGVH-----LPFVGYSYSCMALR 406
Query: 722 SQHEP-KTPVAAAGSSKREPSTKGP--EEKVAGKREGLGGLTLREKTWRGGSPEIKRFSA 778
P TP+ EP + P E V+ + E E+
Sbjct: 407 DSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLREL 466
Query: 779 SEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAP 838
EA LE E R A+ ++ A Q E EAR R L+A
Sbjct: 467 QEA--LEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNR-----------DLEAHVR 513
Query: 839 KEETQGEGTSSAGDSEATDRPRPGDLCPPS 868
+ + + E + G + T P P PPS
Sbjct: 514 QLQERMELLQAEGATAVTGVPSPRATDPPS 543
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 214 bits (545), Expect = 5e-55
Identities = 120/312 (38%), Positives = 182/312 (58%), Gaps = 26/312 (8%)
Query: 372 NDFDTIKLISNGAYGAVYLVRH---RDTRQRFAMKKINKQNLILRNQIQQAFVERDILTF 428
+ F+ +K++ G++G V+LV+ D RQ +AMK + K L +R++++ +ERDIL
Sbjct: 66 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTK-MERDILVE 124
Query: 429 AENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYL 488
+PF+V + +F+T L ++++++ GGD T L E + Y AE LAL++L
Sbjct: 125 VNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 184
Query: 489 HNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVC 548
H+ GI++RDLKP+N+L+ GHIKLTDFGLSK + EK A F C
Sbjct: 185 HSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESI----------DHEKKAYSF-----C 229
Query: 549 GTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPE 608
GT EY+APEV+ R+G+ + DWW+ G++++E L G +PF G +E ++ + P
Sbjct: 230 GTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP- 288
Query: 609 GDEALPTEAQLLISSLLQTNPLVRLGAG--GAFEVKQHSFFRDLDWTGLLRQKAE--FIP 664
+ L EAQ L+ L + NP RLGAG G E+K+HSFF +DW L R++ F P
Sbjct: 289 --QFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP 346
Query: 665 HLESEDDTSYFD 676
+DT YFD
Sbjct: 347 ATGRPEDTFYFD 358
Score = 101 bits (251), Expect = 6e-21
Identities = 80/295 (27%), Positives = 132/295 (44%), Gaps = 32/295 (10%)
Query: 380 ISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFC 439
I G+Y H+ T FA+K I+K +I+ +L + ++P ++ +
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEI------LLRYGQHPNIITLKD 481
Query: 440 SFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLK 499
++ +++ +V E ++GG+ + A +EYLH G+VHRDLK
Sbjct: 482 VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK 541
Query: 500 PDNLL-ITSMGH---IKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIA 555
P N+L + G+ I++ DFG +K + A L C T ++A
Sbjct: 542 PSNILYVDESGNPESIRICDFGFAK---------------QLRAENGLLMTPCYTANFVA 586
Query: 556 PEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFG---DTPEELFGQVISDDILWPEGD-E 611
PEV+ RQGY D W++G++LY L G PF DTPEE+ ++ S G
Sbjct: 587 PEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWN 646
Query: 612 ALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHL 666
++ A+ L+S +L +P RL A V +H + D + + PHL
Sbjct: 647 SVSDTAKDLVSKMLHVDPHQRLTAA---LVLRHPWIVHWDQLPQYQLNRQDAPHL 698
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 214 bits (544), Expect = 7e-55
Identities = 121/347 (34%), Positives = 189/347 (54%), Gaps = 25/347 (7%)
Query: 370 GENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 429
G ++F+ I+++ G++G V L R ++T +A+K + K ++ + ++ E+ IL+ A
Sbjct: 351 GIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLA 410
Query: 430 EN-PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYL 488
N PF+ +FC F+T L VME+V GGD ++ AR Y AE + AL +L
Sbjct: 411 RNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFL 470
Query: 489 HNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVC 548
H+ GI++RDLK DN+L+ GH KL DFG+ K G+ + T C
Sbjct: 471 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTT---------------ATFC 515
Query: 549 GTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPE 608
GTP+YIAPE++ YG VDWWAMG++LYE L G PF + ++LF +++D++++P
Sbjct: 516 GTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPT 575
Query: 609 GDEALPTEAQLLISSLLQTNPLVRLGA---GGAFEVKQHSFFRDLDWTGLLRQKAE--FI 663
L +A ++ S + NP +RLG+ GG + +H FF+++DW L ++ E F
Sbjct: 576 W---LHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFR 632
Query: 664 PHLESEDDTSYFDTRSDRYHHV-NSYDEDDTTEEEPVEIRQFSSCSP 709
P ++S +D S FD + V DE E R FS SP
Sbjct: 633 PRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSP 679
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 214 bits (544), Expect = 7e-55
Identities = 116/307 (37%), Positives = 179/307 (58%), Gaps = 23/307 (7%)
Query: 373 DFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFA-EN 431
DF K++ G++G V+L + T Q FA+K + K +++ + ++ VE+ +L+ A E+
Sbjct: 379 DFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEH 438
Query: 432 PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNY 491
PF+ MFC+F+T+ +L VMEY+ GGD +++ + A Y AE +L L++LH+
Sbjct: 439 PFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSK 498
Query: 492 GIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTP 551
GIV+RDLK DN+L+ GHIK+ DFG+ K ++ DA+ CGTP
Sbjct: 499 GIVYRDLKLDNILLDKDGHIKIADFGMCKENMLG------------DAK---TNTFCGTP 543
Query: 552 EYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDE 611
+YIAPE++L Q Y VDWW+ G++LYE L+G PF G EELF + D+ +P
Sbjct: 544 DYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRW-- 601
Query: 612 ALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAE--FIPHLESE 669
L EA+ L+ L P RLG G +++QH FR+++W L R++ + F P ++S
Sbjct: 602 -LEKEAKDLLVKLFVREPEKRLGVRG--DIRQHPLFREINWEELERKEIDPPFRPKVKSP 658
Query: 670 DDTSYFD 676
D S FD
Sbjct: 659 FDCSNFD 665
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 213 bits (542), Expect = 1e-54
Identities = 158/513 (30%), Positives = 232/513 (45%), Gaps = 49/513 (9%)
Query: 372 NDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 431
+DF+ +K+I GA+ V +V+ + T Q +AMK +NK +++ R ++ ERD+L +
Sbjct: 79 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
Query: 432 PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGA-LPVEMARMYFAETVLALEYLHN 490
++ + +F+ +L +VMEY GGD TLL G +P EMAR Y AE V+A++ +H
Sbjct: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
Query: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550
G VHRD+KPDN+L+ GHI+L DFG + + + R + GT
Sbjct: 199 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 244
Query: 551 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 601
P+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 245 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 304
Query: 602 DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAE 661
+ + P DE +P EA+ I LL P RLG GGA + + H FF LDW GL
Sbjct: 305 EHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
Query: 662 FIPHLESEDDTSYFDTRSDRYHHVNSYDED---DTTEEEPVEIRQFSSCSPRFSKVYSSM 718
F P E DT FD D + S + D E P+ + P YS M
Sbjct: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVH-----LPFVGYSYSCM 418
Query: 719 EQLSQHEP-KTPVAAAGSSKREPSTKGP--EEKVAGKREGLGGLTLREKTWRGGSPEIKR 775
P TP+ EP + P E V+ + E E+
Sbjct: 419 ALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTL 478
Query: 776 FSASEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDA 835
EA LE E R A+ ++ A Q E EAR R L+A
Sbjct: 479 RELQEA--LEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNR-----------DLEA 525
Query: 836 RAPKEETQGEGTSSAGDSEATDRPRPGDLCPPS 868
+ + + E + G + T P P PPS
Sbjct: 526 HVRQLQERMELLQAEGATAVTGVPSPRATDPPS 558
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 213 bits (542), Expect = 1e-54
Identities = 158/513 (30%), Positives = 232/513 (45%), Gaps = 49/513 (9%)
Query: 372 NDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 431
+DF+ +K+I GA+ V +V+ + T Q +AMK +NK +++ R ++ ERD+L +
Sbjct: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
Query: 432 PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGA-LPVEMARMYFAETVLALEYLHN 490
++ + +F+ +L +VMEY GGD TLL G +P EMAR Y AE V+A++ +H
Sbjct: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
Query: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550
G VHRD+KPDN+L+ GHI+L DFG + + + R + GT
Sbjct: 189 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 234
Query: 551 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 601
P+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
Query: 602 DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAE 661
+ + P DE +P EA+ I LL P RLG GGA + + H FF LDW GL
Sbjct: 295 EHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
Query: 662 FIPHLESEDDTSYFDTRSDRYHHVNSYDED---DTTEEEPVEIRQFSSCSPRFSKVYSSM 718
F P E DT FD D + S + D E P+ + P YS M
Sbjct: 354 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVH-----LPFVGYSYSCM 408
Query: 719 EQLSQHEP-KTPVAAAGSSKREPSTKGP--EEKVAGKREGLGGLTLREKTWRGGSPEIKR 775
P TP+ EP + P E V+ + E E+
Sbjct: 409 ALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTL 468
Query: 776 FSASEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDA 835
EA LE E R A+ ++ A Q E EAR R L+A
Sbjct: 469 RELQEA--LEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNR-----------DLEA 515
Query: 836 RAPKEETQGEGTSSAGDSEATDRPRPGDLCPPS 868
+ + + E + G + T P P PPS
Sbjct: 516 HVRQLQERMELLQAEGATAVTGVPSPRATDPPS 548
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 213 bits (542), Expect = 1e-54
Identities = 117/308 (37%), Positives = 180/308 (58%), Gaps = 24/308 (7%)
Query: 374 FDTIKLISNGAYGAVYLVRHR---DTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAE 430
F+ +K++ G++G V+LVR + D Q +AMK + K +L +R++++ +ERDIL
Sbjct: 73 FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTK-MERDILVEVN 131
Query: 431 NPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHN 490
+PF+V + +F+T L ++++++ GGD T L E + Y AE LAL++LH
Sbjct: 132 HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQ 191
Query: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550
GIV+RDLKP+N+L+ +GHIKLTDFGLSK + EK A F CGT
Sbjct: 192 LGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ----------EKKAYSF-----CGT 236
Query: 551 PEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGD 610
EY+APEV+ R+G+ + DWW+ G++++E L G +PF G E ++ + P
Sbjct: 237 VEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMP--- 293
Query: 611 EALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAE--FIPHLES 668
+ L EAQ L+ L + NP RLG+ G E+K+H FF ++DW L +++ + F P
Sbjct: 294 QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGK 353
Query: 669 EDDTSYFD 676
DDT FD
Sbjct: 354 PDDTFCFD 361
Score = 92.4 bits (228), Expect = 3e-18
Identities = 71/280 (25%), Positives = 125/280 (44%), Gaps = 32/280 (11%)
Query: 380 ISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFC 439
I G+Y H T FA+K I+K +I+ ++ + ++P ++ +
Sbjct: 432 IGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEI------LMRYGQHPNIITLKD 485
Query: 440 SFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLK 499
F+ R++ +V + ++GG+ + A ++YLH G+VHRDLK
Sbjct: 486 VFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK 545
Query: 500 PDNLLI----TSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIA 555
P N+L S I++ DFG +K + L C T ++A
Sbjct: 546 PSNILYMDESASADSIRICDFGFAK---------------QLRGENGLLLTPCYTANFVA 590
Query: 556 PEVILRQGYGKPVDWWAMGIILYEFLVGCVPFF---GDTPEELFGQVISDDILWPEGD-E 611
PEV+++QGY D W++G++ Y L G PF DTPEE+ ++ + G+ +
Sbjct: 591 PEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWD 650
Query: 612 ALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLD 651
+ A+ L+S +L +P R A ++ +HS+ D
Sbjct: 651 NISDGAKDLLSHMLHMDPHQRYTAE---QILKHSWITHRD 687
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,220,899
Number of Sequences: 37866
Number of extensions: 4163872
Number of successful extensions: 28085
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 827
Number of HSP's successfully gapped in prelim test: 1254
Number of HSP's that attempted gapping in prelim test: 18373
Number of HSP's gapped (non-prelim): 8726
length of query: 1570
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1454
effective length of database: 13,855,062
effective search space: 20145260148
effective search space used: 20145260148
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.