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Search of human proteins with 4507233
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]
(211 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens] 430 e-121
gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens] 88 5e-18
gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens] 86 2e-17
gi|195976771 cytokine-inducible SH2-containing protein isoform 1... 77 1e-14
gi|21614507 cytokine-inducible SH2-containing protein isoform 2 ... 77 1e-14
gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens] 56 2e-08
gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens] 54 1e-07
gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens] 54 1e-07
gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens] 53 2e-07
gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens] 52 3e-07
gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens] 52 3e-07
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 44 8e-05
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 44 8e-05
gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta... 44 1e-04
gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 43 2e-04
gi|68989256 ras inhibitor RIN1 [Homo sapiens] 41 6e-04
gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 40 0.001
gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alp... 40 0.001
gi|157738639 tensin 4 [Homo sapiens] 39 0.003
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ... 38 0.007
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 38 0.007
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 38 0.007
gi|154146199 sal-like 3 [Homo sapiens] 38 0.007
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 37 0.012
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 37 0.016
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 37 0.016
gi|194328732 Src-like-adaptor isoform c [Homo sapiens] 37 0.016
gi|194328725 Src-like-adaptor isoform b [Homo sapiens] 37 0.016
gi|223972704 hypothetical protein LOC284418 [Homo sapiens] 35 0.036
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 35 0.047
>gi|4507233 suppressor of cytokine signaling 1 [Homo sapiens]
Length = 211
Score = 430 bits (1106), Expect = e-121
Identities = 211/211 (100%), Positives = 211/211 (100%)
Query: 1 MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRS 60
MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRS
Sbjct: 1 MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRS 60
Query: 61 HADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMA 120
HADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMA
Sbjct: 61 HADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMA 120
Query: 121 SGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQ 180
SGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQ
Sbjct: 121 SGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQ 180
Query: 181 RIVATVGRENLARIPLNPVLRDYLSSFPFQI 211
RIVATVGRENLARIPLNPVLRDYLSSFPFQI
Sbjct: 181 RIVATVGRENLARIPLNPVLRDYLSSFPFQI 211
>gi|4507263 suppressor of cytokine signaling-2 [Homo sapiens]
Length = 198
Score = 88.2 bits (217), Expect = 5e-18
Identities = 57/167 (34%), Positives = 85/167 (50%), Gaps = 24/167 (14%)
Query: 66 RITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTS 125
R+ +A L G+YWG ++V+ A E+L+ P GTFL+RDS + +SVK ++GPT+
Sbjct: 35 RLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTN 94
Query: 126 IRVHFQAGRFHLD------GSRESFDCLFELLEHYV----------AAPRR-----MLGA 164
+R+ +Q G+F LD + FD + L+++YV APR L
Sbjct: 95 LRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTK 154
Query: 165 PLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI 211
PL LQ LCR I G + +PL L+DYL + FQ+
Sbjct: 155 PL-YTSAPSLQHLCRLTINKCTGA--IWGLPLPTRLKDYLEEYKFQV 198
>gi|45439352 suppressor of cytokine signaling 3 [Homo sapiens]
Length = 225
Score = 86.3 bits (212), Expect = 2e-17
Identities = 51/131 (38%), Positives = 68/131 (51%), Gaps = 12/131 (9%)
Query: 43 PAVPAPAPGDTHFR--TFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGT 100
PA P DT R TF S ++Y+ + A L GFYW ++ A+ L AEP GT
Sbjct: 8 PAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGT 67
Query: 101 FLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRES------FDCLFELLEHY 154
FL+RDS + FF LSVK SG ++R+ + G F L S FDC+ +L+ HY
Sbjct: 68 FLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 127
Query: 155 VAAPRRMLGAP 165
+ P GAP
Sbjct: 128 MPPP----GAP 134
>gi|195976771 cytokine-inducible SH2-containing protein isoform 1
[Homo sapiens]
Length = 275
Score = 76.6 bits (187), Expect = 1e-14
Identities = 62/213 (29%), Positives = 88/213 (41%), Gaps = 54/213 (25%)
Query: 48 PAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSR 107
PA ++ + D I + + L G+YWG ++ A + L+ P GTFLVRDS
Sbjct: 68 PAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDST 127
Query: 108 QRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRES------FDCLFELLEHYVA----- 156
+ F LSVK GPT++R+ + F LD + S F + L++HYVA
Sbjct: 128 HPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTAD 187
Query: 157 --------APRRMLGAP---------------------------LRQRRVRPLQELCR-- 179
AP L P +R+ R LQ LCR
Sbjct: 188 TRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLV 247
Query: 180 -QRIVATVGRENLARIPLNPVLRDYLSSFPFQI 211
R+VA V +PL + DYL +PFQ+
Sbjct: 248 INRLVADVD-----CLPLPRRMADYLRQYPFQL 275
>gi|21614507 cytokine-inducible SH2-containing protein isoform 2
[Homo sapiens]
Length = 258
Score = 76.6 bits (187), Expect = 1e-14
Identities = 62/213 (29%), Positives = 88/213 (41%), Gaps = 54/213 (25%)
Query: 48 PAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSR 107
PA ++ + D I + + L G+YWG ++ A + L+ P GTFLVRDS
Sbjct: 51 PAQTESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDST 110
Query: 108 QRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRES------FDCLFELLEHYVA----- 156
+ F LSVK GPT++R+ + F LD + S F + L++HYVA
Sbjct: 111 HPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTAD 170
Query: 157 --------APRRMLGAP---------------------------LRQRRVRPLQELCR-- 179
AP L P +R+ R LQ LCR
Sbjct: 171 TRSDSPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLVQPFVRRSSARSLQHLCRLV 230
Query: 180 -QRIVATVGRENLARIPLNPVLRDYLSSFPFQI 211
R+VA V +PL + DYL +PFQ+
Sbjct: 231 INRLVADVD-----CLPLPRRMADYLRQYPFQL 258
>gi|53831997 suppressor of cytokine signaling 7 [Homo sapiens]
Length = 581
Score = 56.2 bits (134), Expect = 2e-08
Identities = 56/215 (26%), Positives = 83/215 (38%), Gaps = 37/215 (17%)
Query: 30 SSSPAAPARPRPCPAVPAPAPGDTHFRTFRS-HAD---------YRRITRASAL----LD 75
SS + P P P P P P R S H+ YR + + A L+
Sbjct: 337 SSLQSFPLPPPPPPHAPDAFPRIAPIRAAESLHSQPPQHLQCPLYRPDSSSFAASLRELE 396
Query: 76 ACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRF 135
CG+YWGP++ A +L+ +P G+FLVRDS +LS + R+ G F
Sbjct: 397 KCGWYWGPMNWEDAEMKLKGKPDGSFLVRDSSDPRYILSLSFRSQGITHHTRMEHYRGTF 456
Query: 136 HL-------DGSRESFDCLFELLEH----------------YVAAPRRMLGAPLRQRRVR 172
L D + + + + H P ++L R V+
Sbjct: 457 SLWCHPKFEDRCQSVVEFIKRAIMHSKNGKFLYFLRSRVPGLPPTPVQLLYPVSRFSNVK 516
Query: 173 PLQELCRQRIVATVGRENLARIPLNPVLRDYLSSF 207
LQ LCR RI V +++ +PL L Y+ F
Sbjct: 517 SLQHLCRFRIRQLVRIDHIPDLPLPKPLISYIRKF 551
>gi|21618354 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 53.5 bits (127), Expect = 1e-07
Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 14/142 (9%)
Query: 80 YWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG 139
YWG + + A L +P GTFL+RDS Q + F++S + + R+ F D
Sbjct: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
Query: 140 SRESFDCLFE------LLEHYVAAPRRMLGAPL---RQRRVRP--LQELCRQRIVATVGR 188
C+F LLEHY M PL R P LQ +CR I
Sbjct: 442 HD---PCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTY 498
Query: 189 ENLARIPLNPVLRDYLSSFPFQ 210
+ + +PL +L+D+L + ++
Sbjct: 499 DGIDGLPLPSMLQDFLKEYHYK 520
>gi|7662240 suppressor of cytokine signaling 5 [Homo sapiens]
Length = 536
Score = 53.5 bits (127), Expect = 1e-07
Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 14/142 (9%)
Query: 80 YWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG 139
YWG + + A L +P GTFL+RDS Q + F++S + + R+ F D
Sbjct: 382 YWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDA 441
Query: 140 SRESFDCLFE------LLEHYVAAPRRMLGAPL---RQRRVRP--LQELCRQRIVATVGR 188
C+F LLEHY M PL R P LQ +CR I
Sbjct: 442 HD---PCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTY 498
Query: 189 ENLARIPLNPVLRDYLSSFPFQ 210
+ + +PL +L+D+L + ++
Sbjct: 499 DGIDGLPLPSMLQDFLKEYHYK 520
>gi|21450785 suppressor of cytokine signaling 6 [Homo sapiens]
Length = 535
Score = 53.1 bits (126), Expect = 2e-07
Identities = 41/148 (27%), Positives = 62/148 (41%), Gaps = 21/148 (14%)
Query: 78 GFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGR--F 135
G+YWGP++ A +L P G+FLVRDS +LS + R+ GR F
Sbjct: 383 GWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSF 442
Query: 136 HLDGSRESFDCLFELLEHYV-------------------AAPRRMLGAPLRQRRVRPLQE 176
+ E + +L+EH + P R+ R +VR LQ
Sbjct: 443 YEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQY 502
Query: 177 LCRQRIVATVGRENLARIPLNPVLRDYL 204
LCR I + + ++PL ++DYL
Sbjct: 503 LCRFVIRQYTRIDLIQKLPLPNKMKDYL 530
>gi|40807480 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 52.4 bits (124), Expect = 3e-07
Identities = 39/142 (27%), Positives = 60/142 (42%), Gaps = 14/142 (9%)
Query: 80 YWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG 139
YWG + + A L +P GTFL+RDS Q + F++S + S R+ F D
Sbjct: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDA 346
Query: 140 SRESFDCLFE------LLEHYVAAPRRM-----LGAPLRQRRVRPLQELCRQRIVATVGR 188
C+F LLEHY M L PL + LQ +CR I
Sbjct: 347 HD---PCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTY 403
Query: 189 ENLARIPLNPVLRDYLSSFPFQ 210
+ + +P+ ++ YL + ++
Sbjct: 404 DGIDALPIPSSMKLYLKEYHYK 425
>gi|18254466 suppressor of cytokine signaling 4 [Homo sapiens]
Length = 440
Score = 52.4 bits (124), Expect = 3e-07
Identities = 39/142 (27%), Positives = 60/142 (42%), Gaps = 14/142 (9%)
Query: 80 YWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDG 139
YWG + + A L +P GTFL+RDS Q + F++S + S R+ F D
Sbjct: 287 YWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDA 346
Query: 140 SRESFDCLFE------LLEHYVAAPRRM-----LGAPLRQRRVRPLQELCRQRIVATVGR 188
C+F LLEHY M L PL + LQ +CR I
Sbjct: 347 HD---PCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTY 403
Query: 189 ENLARIPLNPVLRDYLSSFPFQ 210
+ + +P+ ++ YL + ++
Sbjct: 404 DGIDALPIPSSMKLYLKEYHYK 425
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 44.3 bits (103), Expect = 8e-05
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 70 ASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRD-SRQRNCFFALSVKMASGPTSIRV 128
+S L +YWG +S +++LR P GTFLVRD S + + L+++ I++
Sbjct: 56 SSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKI 115
Query: 129 HFQAGRFHLDGSRESFDCLFELLEHY 154
+ + G++ +F+ + EL+ HY
Sbjct: 116 YHRDGKYGFSDPL-TFNSVVELINHY 140
Score = 27.7 bits (60), Expect = 7.4
Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 3/67 (4%)
Query: 89 AHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGR-FHLDGSRESFDCL 147
A + L +P G FL+R+S ++ C +A SV +A G V + R + + L
Sbjct: 368 AEDLLYGKPDGAFLIRESSKKGC-YACSV-VADGEVKHCVIYSTARGYGFAEPYNLYSSL 425
Query: 148 FELLEHY 154
EL+ HY
Sbjct: 426 KELVLHY 432
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 44.3 bits (103), Expect = 8e-05
Identities = 25/86 (29%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 70 ASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRD-SRQRNCFFALSVKMASGPTSIRV 128
+S L +YWG +S +++LR P GTFLVRD S + + L+++ I++
Sbjct: 56 SSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKI 115
Query: 129 HFQAGRFHLDGSRESFDCLFELLEHY 154
+ + G++ +F+ + EL+ HY
Sbjct: 116 YHRDGKYGFSDPL-TFNSVVELINHY 140
Score = 27.7 bits (60), Expect = 7.4
Identities = 21/67 (31%), Positives = 33/67 (49%), Gaps = 3/67 (4%)
Query: 89 AHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGR-FHLDGSRESFDCL 147
A + L +P G FL+R+S ++ C +A SV +A G V + R + + L
Sbjct: 368 AEDLLYGKPDGAFLIRESSKKGC-YACSV-VADGEVKHCVIYSTARGYGFAEPYNLYSSL 425
Query: 148 FELLEHY 154
EL+ HY
Sbjct: 426 KELVLHY 432
>gi|4826908 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
[Homo sapiens]
Length = 728
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/106 (27%), Positives = 51/106 (48%), Gaps = 2/106 (1%)
Query: 79 FYWGPLSVHGAHERLRAEPVGTFLVRDSRQR-NCFFALSVKMASGPTSIRVHFQAGRFHL 137
+YWG +S +E+LR P GTFLVRD+ + + L+++ I+V + G +
Sbjct: 330 WYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGF 389
Query: 138 DGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIV 183
+F + +L+ HY A L R + P+ + + +IV
Sbjct: 390 -SEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIV 434
Score = 34.3 bits (77), Expect = 0.079
Identities = 24/76 (31%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 79 FYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLD 138
+Y G ++ A E L + GTFL+R+S QR C +A SV + ++ A F
Sbjct: 622 WYVGKINRTQAEEMLSGKRDGTFLIRESSQRGC-YACSVVVDGDTKHCVIYRTATGFGFA 680
Query: 139 GSRESFDCLFELLEHY 154
+ L EL+ HY
Sbjct: 681 EPYNLYGSLKELVLHY 696
>gi|32455248 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 1 [Homo sapiens]
Length = 724
Score = 42.7 bits (99), Expect = 2e-04
Identities = 32/116 (27%), Positives = 54/116 (46%), Gaps = 10/116 (8%)
Query: 40 RPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVG 99
+P PA+P P T + +L DA +YWG +S +E+LR G
Sbjct: 302 QPAPALPPKPPKPTTVAN-------NGMNNNMSLQDA-EWYWGDISREEVNEKLRDTADG 353
Query: 100 TFLVRD-SRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHY 154
TFLVRD S + + + L+++ I++ + G++ +F + EL+ HY
Sbjct: 354 TFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPL-TFSSVVELINHY 408
Score = 27.3 bits (59), Expect = 9.7
Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 89 AHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLF 148
A LR + GTFLVR+S ++ C +A SV + ++ A + + L
Sbjct: 634 AENLLRGKRDGTFLVRESSKQGC-YACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLK 692
Query: 149 ELLEHY 154
EL+ HY
Sbjct: 693 ELVLHY 698
>gi|68989256 ras inhibitor RIN1 [Homo sapiens]
Length = 783
Score = 41.2 bits (95), Expect = 6e-04
Identities = 31/82 (37%), Positives = 41/82 (50%), Gaps = 5/82 (6%)
Query: 93 LRAEPVGTFLVRDSRQRNC-FFALSVKMASGPTSIRVHF---QAGRFHLDGSRESFDCLF 148
LR EP GTFLVR S R C + + ASGP+ + H+ G L+GS F L
Sbjct: 83 LRTEPPGTFLVRKSNTRQCQALCMRLPEASGPSFVSSHYILESPGGVSLEGSELMFPDLV 142
Query: 149 ELLEHYVAAPRRMLGAPLRQRR 170
+L+ Y R +L PL+ R
Sbjct: 143 QLICAY-CHTRDILLLPLQLPR 163
>gi|32455252 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 2 [Homo sapiens]
Length = 454
Score = 40.4 bits (93), Expect = 0.001
Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 79 FYWGPLSVHGAHERLRAEPVGTFLVRD-SRQRNCFFALSVKMASGPTSIRVHFQAGRFHL 137
+YWG +S +E+LR GTFLVRD S + + + L+++ I++ + G++
Sbjct: 63 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 122
Query: 138 DGSRESFDCLFELLEHY 154
+F + EL+ HY
Sbjct: 123 SDPL-TFSSVVELINHY 138
Score = 27.3 bits (59), Expect = 9.7
Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 89 AHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLF 148
A LR + GTFLVR+S ++ C +A SV + ++ A + + L
Sbjct: 364 AENLLRGKRDGTFLVRESSKQGC-YACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLK 422
Query: 149 ELLEHY 154
EL+ HY
Sbjct: 423 ELVLHY 428
>gi|32455250 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
isoform 3 [Homo sapiens]
Length = 424
Score = 40.4 bits (93), Expect = 0.001
Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 2/77 (2%)
Query: 79 FYWGPLSVHGAHERLRAEPVGTFLVRD-SRQRNCFFALSVKMASGPTSIRVHFQAGRFHL 137
+YWG +S +E+LR GTFLVRD S + + + L+++ I++ + G++
Sbjct: 33 WYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGF 92
Query: 138 DGSRESFDCLFELLEHY 154
+F + EL+ HY
Sbjct: 93 SDPL-TFSSVVELINHY 108
Score = 27.3 bits (59), Expect = 9.7
Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 89 AHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLF 148
A LR + GTFLVR+S ++ C +A SV + ++ A + + L
Sbjct: 334 AENLLRGKRDGTFLVRESSKQGC-YACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLK 392
Query: 149 ELLEHY 154
EL+ HY
Sbjct: 393 ELVLHY 398
>gi|157738639 tensin 4 [Homo sapiens]
Length = 715
Score = 38.9 bits (89), Expect = 0.003
Identities = 28/111 (25%), Positives = 47/111 (42%), Gaps = 1/111 (0%)
Query: 16 AAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLD 75
++ P+R P +S A+P+ P P + D F T ++D
Sbjct: 385 SSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMD 444
Query: 76 ACGFYWGP-LSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTS 125
+++ P ++ A E LR E G F++RDS F L++K+ P S
Sbjct: 445 TSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPAS 495
>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 287
Score = 37.7 bits (86), Expect = 0.007
Identities = 34/121 (28%), Positives = 54/121 (44%), Gaps = 36/121 (29%)
Query: 40 RPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPV- 98
+PCP VP P DY +C ++ GA ERL+AE
Sbjct: 96 KPCPCVPKPV-------------DY-----------SCQPWYA-----GAMERLQAETEL 126
Query: 99 -----GTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEH 153
T+LVR + + +A+S+K + I++ + G FH+ +R+ F L EL+E+
Sbjct: 127 INRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRK-FKSLMELVEY 185
Query: 154 Y 154
Y
Sbjct: 186 Y 186
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 37.7 bits (86), Expect = 0.007
Identities = 34/121 (28%), Positives = 54/121 (44%), Gaps = 36/121 (29%)
Query: 40 RPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPV- 98
+PCP VP P DY +C ++ GA ERL+AE
Sbjct: 656 KPCPCVPKPV-------------DY-----------SCQPWYA-----GAMERLQAETEL 686
Query: 99 -----GTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEH 153
T+LVR + + +A+S+K + I++ + G FH+ +R+ F L EL+E+
Sbjct: 687 INRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRK-FKSLMELVEY 745
Query: 154 Y 154
Y
Sbjct: 746 Y 746
>gi|18104991 protein tyrosine phosphatase, non-receptor type 6
isoform 2 [Homo sapiens]
Length = 597
Score = 37.7 bits (86), Expect = 0.007
Identities = 28/78 (35%), Positives = 40/78 (51%), Gaps = 2/78 (2%)
Query: 78 GFYWGPLSVHGAHERLRAEPV-GTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFH 136
G++ LS A L+ V G+FL R SR+ F+LSV++ T IR+ +
Sbjct: 5 GWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 64
Query: 137 LDGSRESFDCLFELLEHY 154
L G E F L EL+E+Y
Sbjct: 65 LYGG-EKFATLTELVEYY 81
Score = 36.6 bits (83), Expect = 0.016
Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 13/87 (14%)
Query: 79 FYWGPLSVHGAHERLRA--EPVGTFLVRDSRQRNCFFALSV---KMASGP------TSIR 127
+Y G +S A L+A EP TFLVR+S + F LSV + +GP T I+
Sbjct: 112 WYHGHMSGGQAETLLQAKGEP-WTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 170
Query: 128 VHFQAGRFHLDGSRESFDCLFELLEHY 154
V + GR+ + G E+FD L +L+EH+
Sbjct: 171 VMCEGGRYTV-GGLETFDSLTDLVEHF 196
>gi|154146199 sal-like 3 [Homo sapiens]
Length = 1300
Score = 37.7 bits (86), Expect = 0.007
Identities = 19/44 (43%), Positives = 23/44 (52%), Gaps = 5/44 (11%)
Query: 12 AVSTAAEPRRRPEPSSSSSSSPAAPARP-----RPCPAVPAPAP 50
A A+P RPE +S+ PA P+ P P PA PAPAP
Sbjct: 284 AAFEGAQPLSRPESGASTPGGPAEPSAPAAPSAAPAPAAPAPAP 327
Score = 29.3 bits (64), Expect = 2.6
Identities = 18/44 (40%), Positives = 23/44 (52%), Gaps = 3/44 (6%)
Query: 8 AADNAVSTAAEPRRRP--EPSSSSSSSPAAPAR-PRPCPAVPAP 48
AA+ A + AE RP + + + PA R PRP PA PAP
Sbjct: 111 AAEEAGAEGAEGEARPVEKEAEPMDAEPAGDTRAPRPPPAAPAP 154
Score = 29.3 bits (64), Expect = 2.6
Identities = 17/44 (38%), Positives = 22/44 (50%), Gaps = 6/44 (13%)
Query: 8 AADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPG 51
AA +A A P P P S++SS P + + P PA APG
Sbjct: 312 AAPSAAPAPAAPAPAPAPQSAASSQPQSASTP------PALAPG 349
>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
[Homo sapiens]
Length = 303
Score = 37.0 bits (84), Expect = 0.012
Identities = 29/80 (36%), Positives = 38/80 (47%), Gaps = 1/80 (1%)
Query: 75 DACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGR 134
D +Y GP+S A RL+ + G FLVRDS + LSV S + ++ R
Sbjct: 10 DRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNR 69
Query: 135 FHLDGSRESFDCLFELLEHY 154
G +E FD L LLE Y
Sbjct: 70 RFKIGDQE-FDHLPALLEFY 88
>gi|18104993 protein tyrosine phosphatase, non-receptor type 6
isoform 3 [Homo sapiens]
Length = 624
Score = 36.6 bits (83), Expect = 0.016
Identities = 22/56 (39%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 99 GTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHY 154
G+FL R SR+ F+LSV++ T IR+ + L G E F L EL+E+Y
Sbjct: 25 GSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGG-EKFATLTELVEYY 79
Score = 36.6 bits (83), Expect = 0.016
Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 13/87 (14%)
Query: 79 FYWGPLSVHGAHERLRA--EPVGTFLVRDSRQRNCFFALSV---KMASGP------TSIR 127
+Y G +S A L+A EP TFLVR+S + F LSV + +GP T I+
Sbjct: 110 WYHGHMSGGQAETLLQAKGEP-WTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 168
Query: 128 VHFQAGRFHLDGSRESFDCLFELLEHY 154
V + GR+ + G E+FD L +L+EH+
Sbjct: 169 VMCEGGRYTV-GGLETFDSLTDLVEHF 194
>gi|18104989 protein tyrosine phosphatase, non-receptor type 6
isoform 1 [Homo sapiens]
Length = 595
Score = 36.6 bits (83), Expect = 0.016
Identities = 22/56 (39%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 99 GTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHY 154
G+FL R SR+ F+LSV++ T IR+ + L G E F L EL+E+Y
Sbjct: 25 GSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGG-EKFATLTELVEYY 79
Score = 36.6 bits (83), Expect = 0.016
Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 13/87 (14%)
Query: 79 FYWGPLSVHGAHERLRA--EPVGTFLVRDSRQRNCFFALSV---KMASGP------TSIR 127
+Y G +S A L+A EP TFLVR+S + F LSV + +GP T I+
Sbjct: 110 WYHGHMSGGQAETLLQAKGEP-WTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIK 168
Query: 128 VHFQAGRFHLDGSRESFDCLFELLEHY 154
V + GR+ + G E+FD L +L+EH+
Sbjct: 169 VMCEGGRYTV-GGLETFDSLTDLVEHF 194
>gi|194328732 Src-like-adaptor isoform c [Homo sapiens]
Length = 316
Score = 36.6 bits (83), Expect = 0.016
Identities = 44/172 (25%), Positives = 70/172 (40%), Gaps = 32/172 (18%)
Query: 14 STAAEPRRRPEPSSSSSSSPAAPARPRPCP--------AVPAPAPG-DTHFRTFRSHADY 64
++ A P ++ E +S S+PA RP P P AV + P D FR
Sbjct: 30 ASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKL 89
Query: 65 RRIT--------------RASALLDAC------GFYWGPLSVHGAHERLRAEP--VGTFL 102
R I+ R S + C G+ + L A E L+ VG+F+
Sbjct: 90 RVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFM 149
Query: 103 VRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHY 154
+R+S + F++LSV+ R+ ++ R +F CL +L+ HY
Sbjct: 150 IRESETKKGFYSLSVRHRQ-VKHYRIFRLPNNWYYISPRLTFQCLEDLVNHY 200
>gi|194328725 Src-like-adaptor isoform b [Homo sapiens]
Length = 293
Score = 36.6 bits (83), Expect = 0.016
Identities = 44/172 (25%), Positives = 70/172 (40%), Gaps = 32/172 (18%)
Query: 14 STAAEPRRRPEPSSSSSSSPAAPARPRPCP--------AVPAPAPG-DTHFRTFRSHADY 64
++ A P ++ E +S S+PA RP P P AV + P D FR
Sbjct: 7 ASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKL 66
Query: 65 RRIT--------------RASALLDAC------GFYWGPLSVHGAHERLRAEP--VGTFL 102
R I+ R S + C G+ + L A E L+ VG+F+
Sbjct: 67 RVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFM 126
Query: 103 VRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHY 154
+R+S + F++LSV+ R+ ++ R +F CL +L+ HY
Sbjct: 127 IRESETKKGFYSLSVRHRQ-VKHYRIFRLPNNWYYISPRLTFQCLEDLVNHY 177
>gi|223972704 hypothetical protein LOC284418 [Homo sapiens]
Length = 922
Score = 35.4 bits (80), Expect = 0.036
Identities = 15/38 (39%), Positives = 23/38 (60%)
Query: 12 AVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPA 49
A + +A PR+ P + S +PA PA + PA+PAP+
Sbjct: 442 APAASAPPRKAPAVPAPSQKAPAVPAPSQKAPAIPAPS 479
Score = 32.7 bits (73), Expect = 0.23
Identities = 14/33 (42%), Positives = 20/33 (60%)
Query: 17 AEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPA 49
A P++ P S+ +PA PA + PAVPAP+
Sbjct: 437 APPQKAPAASAPPRKAPAVPAPSQKAPAVPAPS 469
Score = 29.3 bits (64), Expect = 2.6
Identities = 14/29 (48%), Positives = 18/29 (62%), Gaps = 1/29 (3%)
Query: 22 RPEPS-SSSSSSPAAPARPRPCPAVPAPA 49
+P P + +PAA A PR PAVPAP+
Sbjct: 431 KPPPGLAPPQKAPAASAPPRKAPAVPAPS 459
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 35.0 bits (79), Expect = 0.047
Identities = 25/81 (30%), Positives = 39/81 (48%), Gaps = 3/81 (3%)
Query: 79 FYWGPLSVHGAHERLRAEPV-GTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHL 137
+Y+G ++ H A L V G FL+RDS F++S+K + +V + +
Sbjct: 285 WYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCI 344
Query: 138 DGSRESFDCLFELLEHYVAAP 158
R F + EL+EHY AP
Sbjct: 345 GQRR--FHTMDELVEHYKKAP 363
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.136 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,166,742
Number of Sequences: 37866
Number of extensions: 496121
Number of successful extensions: 10076
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 229
Number of HSP's successfully gapped in prelim test: 278
Number of HSP's that attempted gapping in prelim test: 8332
Number of HSP's gapped (non-prelim): 1767
length of query: 211
length of database: 18,247,518
effective HSP length: 98
effective length of query: 113
effective length of database: 14,536,650
effective search space: 1642641450
effective search space used: 1642641450
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.