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Search of human proteins with 4506975
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
(1212 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 2403 0.0
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 1361 0.0
gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo ... 1074 0.0
gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo ... 1072 0.0
gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo ... 1068 0.0
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 286 8e-77
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 254 3e-67
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 231 4e-60
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 231 4e-60
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 231 4e-60
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 231 4e-60
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 231 4e-60
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 223 1e-57
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 223 1e-57
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 223 1e-57
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 223 1e-57
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 223 1e-57
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 223 1e-57
gi|198041678 solute carrier family 12 (potassium-chloride transp... 221 3e-57
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 221 3e-57
gi|123701900 solute carrier family 12 (potassium/chloride transp... 221 4e-57
gi|110832843 TBP-associated factor 4 [Homo sapiens] 50 1e-05
gi|153070260 myristoylated alanine-rich protein kinase C substra... 49 2e-05
gi|210147522 zinc finger, SWIM-type containing 6 [Homo sapiens] 48 5e-05
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 48 5e-05
gi|24497554 homeobox A13 [Homo sapiens] 47 1e-04
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 47 1e-04
gi|126090909 engrailed homeobox 1 [Homo sapiens] 47 1e-04
gi|39812496 Sp8 transcription factor isoform 1 [Homo sapiens] 45 4e-04
gi|39812501 Sp8 transcription factor isoform 2 [Homo sapiens] 45 5e-04
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 2403 bits (6227), Expect = 0.0
Identities = 1212/1212 (100%), Positives = 1212/1212 (100%)
Query: 1 MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEG 60
MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEG
Sbjct: 1 MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEG 60
Query: 61 PAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADG 120
PAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADG
Sbjct: 61 PAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADG 120
Query: 121 EASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLS 180
EASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLS
Sbjct: 121 EASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLS 180
Query: 181 EGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLR 240
EGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLR
Sbjct: 181 EGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLR 240
Query: 241 PSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIW 300
PSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIW
Sbjct: 241 PSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIW 300
Query: 301 GVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSL 360
GVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSL
Sbjct: 301 GVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSL 360
Query: 361 GPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVIL 420
GPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVIL
Sbjct: 361 GPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVIL 420
Query: 421 LGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPD 480
LGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPD
Sbjct: 421 LGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPD 480
Query: 481 FREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSV 540
FREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSV
Sbjct: 481 FREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSV 540
Query: 541 GSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFT 600
GSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFT
Sbjct: 541 GSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFT 600
Query: 601 PLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFL 660
PLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFL
Sbjct: 601 PLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFL 660
Query: 661 IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA 720
IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA
Sbjct: 661 IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA 720
Query: 721 ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV 780
ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV
Sbjct: 721 ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV 780
Query: 781 EDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQA 840
EDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQA
Sbjct: 781 EDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQA 840
Query: 841 KYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDV 900
KYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDV
Sbjct: 841 KYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDV 900
Query: 901 DMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKS 960
DMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKS
Sbjct: 901 DMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKS 960
Query: 961 DLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQG 1020
DLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQG
Sbjct: 961 DLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQG 1020
Query: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFR 1080
KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFR
Sbjct: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFR 1080
Query: 1081 IDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELE 1140
IDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELE
Sbjct: 1081 IDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELE 1140
Query: 1141 LYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLV 1200
LYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLV
Sbjct: 1141 LYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLV 1200
Query: 1201 RGNHQSVLTFYS 1212
RGNHQSVLTFYS
Sbjct: 1201 RGNHQSVLTFYS 1212
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo sapiens]
Length = 1099
Score = 1361 bits (3523), Expect = 0.0
Identities = 703/1151 (61%), Positives = 858/1151 (74%), Gaps = 72/1151 (6%)
Query: 72 LGPTPSQS-RFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAK 130
L PS + RFQV +++EN +AAA D E
Sbjct: 11 LDSVPSNTNRFQVSVINENHESSAAAD---------------------DNTDPPHYEETS 49
Query: 131 GSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGG 190
+EA+ R R++F + D+ F G+T ++ S
Sbjct: 50 FGDEAQKRLRISF--RPGNQECYDN---------------FLQSGETAKTDAS------- 85
Query: 191 GGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDEL 250
+ YD+HTNTYYL+TFGHNTMDAVP+I++YR+T + G K+ RPSL E+H++L
Sbjct: 86 -------FHAYDSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQL 138
Query: 251 EKE-----PFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLF 305
K D ANG+ P + + GVVKFGW+KGVLVRCMLNIWGVMLF
Sbjct: 139 AKNVAVTPSSADRVANGD-GIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLF 197
Query: 306 IRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFG 365
IRLSWIVG+AGIGL VL+I+++T+VT+ITGLSTSAIATNGFVRGGGAYYLISRSLGPEFG
Sbjct: 198 IRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFG 257
Query: 366 GAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISV 425
G+IGLIFAFANAVAVAMYVVGFAETVV+LLKE +M+D NDIRIIG+ITVVILLGISV
Sbjct: 258 GSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISV 317
Query: 426 AGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLES-KKPKGFFGYKSEIFNENFGPDFREE 484
AGMEWEAKAQ++LLVILL+AI +F IGT IP + KK +GFF Y++ IF ENFGP F +
Sbjct: 318 AGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFAENFGPRFTKG 377
Query: 485 ETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCV 544
E FFSVFAIFFPAATGILAGANISGDL DPQ AIP+GT+LAI ITT+ Y+G+A+ VG+CV
Sbjct: 378 EGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACV 437
Query: 545 VRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLIS 604
VRDATGN+NDTI++ + SAAC L +DFS C PC YGLMNNFQVMSMVSGF PLI+
Sbjct: 438 VRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLIT 497
Query: 605 AGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALG 664
AGIFSATLSSALASLVSAPK+FQALCKDNIY A Q FAKGYGKNNEPLRGYILTFLIA+
Sbjct: 498 AGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMA 557
Query: 665 FILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCC 724
FILIAELN IAPIISNFFLASYALINFS FHAS AKSPGWRPA+ YNMW+SL GA+LCC
Sbjct: 558 FILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCC 617
Query: 725 IVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHV 784
VMFVINWWAA++TYVI LY+YVT KKPDVNWGSSTQAL+Y++AL +++ L+ VEDHV
Sbjct: 618 AVMFVINWWAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHV 677
Query: 785 KNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQR 844
KNFRPQC+V+TG P +RPALL + H FTKN GL IC V +GPR+ +KEM+ AK Q
Sbjct: 678 KNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 737
Query: 845 WLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYI 904
WLIKNK+KAFYA V AD R+G + L+QA+GLGRMKPNTLV+G+KK+W +A + +++ Y+
Sbjct: 738 WLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYV 797
Query: 905 NLFHDAFDIQYGVVVIRLKEGLDISH-LQGQEELLSSQEKSPGTKDVVVSVEYSKKSD-- 961
+ HDAFD + GVV++R+ +G DIS LQ QEEL +++ + + E ++S
Sbjct: 798 GIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGI 857
Query: 962 LDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGK 1021
K + IT ++DG T + + +QKL+EASTQF+KKQ K
Sbjct: 858 RGLFKKAGKLNITKTTPKKDGSINTSQSMH---------VGEFNQKLVEASTQFKKKQEK 908
Query: 1022 NTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRI 1081
TIDVWWLFDDGGLTLLIPY+LT +KKWKDCK+R+++GGKINRI+ ++ MA+LLSKFRI
Sbjct: 909 GTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRI 968
Query: 1082 DFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELEL 1141
F+DI ++GDIN +P KE+ FEE+IEPYRLHE K+ A+K+K + PW+ITD ELE
Sbjct: 969 KFADIHIIGDINIRPNKESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEA 1028
Query: 1142 YKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVR 1201
K K+YRQ+RLNELL+EHS AN+IV+SLPVARKG++S LYMAWLE L+K+LPP+LLVR
Sbjct: 1029 VKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVR 1088
Query: 1202 GNHQSVLTFYS 1212
GNH++VLTFYS
Sbjct: 1089 GNHKNVLTFYS 1099
>gi|186910315 solute carrier family 12, member 3 isoform 1 [Homo
sapiens]
Length = 1030
Score = 1074 bits (2777), Expect = 0.0
Identities = 536/1038 (51%), Positives = 728/1038 (70%), Gaps = 67/1038 (6%)
Query: 193 SGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEK 252
S H H TH++T+ +RTFG+NT+D VP +HY ++ + +RP+LA+LH L++
Sbjct: 39 SSHPSHL---THSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQ 95
Query: 253 E---------------PFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCML 297
E DG GE T + + V+FGW+KGV++RCML
Sbjct: 96 EGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEK-------NPEEPVRFGWVKGVMIRCML 148
Query: 298 NIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLIS 357
NIWGV+L++RL WI QAGI L+ ++I+++ VT+ITGLS SAI+TNG V+ GG Y+LIS
Sbjct: 149 NIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLIS 208
Query: 358 RSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITV 417
RSLGPE GG+IGLIFAFANAV VAM+ VGFAETV +LL+E+ ++D INDIRIIG ++V
Sbjct: 209 RSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSV 268
Query: 418 VILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIP-LESKKPKGFFGYKSEIFNEN 476
+LL IS+AGMEWE+KAQ++ ++++++ ++++GT IP E K KGFF Y+++IF +N
Sbjct: 269 TVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQN 328
Query: 477 FGPDFREEE-TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVG 535
PD+R + TFF +F+IFFP+ATGILAGANISGDL DP AIPKGTL+AI TT+ Y+
Sbjct: 329 LVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLA 388
Query: 536 IAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSC-ESSPCSYGLMNNFQVMS 594
I+ ++GSCVVRDA+G +NDT+ C AC ++F+ C + C YGL+N +Q MS
Sbjct: 389 ISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMS 448
Query: 595 MVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRG 654
MVSGF PLI+AGIF ATLSSALA LVSA K+FQ LC+D +YP F KGYGKN EP+RG
Sbjct: 449 MVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRG 508
Query: 655 YILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMW 714
Y+L + IA+ FI+IAELN IAPIISNFFL SYALINFS FHAS+ SPGWRP+F+YYN W
Sbjct: 509 YLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKW 568
Query: 715 ISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHS 774
+L GAI+ ++MF++ WWAAL+ +VL L +YV YKKP+VNWGSS QA +Y AL +S
Sbjct: 569 AALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYS 628
Query: 775 IRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKE 834
+ L+ VEDH+KN+RPQCLV+TG PN RPAL+ V FT+N+ LMICGHV +GP +Q M E
Sbjct: 629 VGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPE 688
Query: 835 MSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQ 894
+ + + +WL K K+KAFY+ V A+DLR G Q LMQAAGLGRMKPN LV+GFKK+W
Sbjct: 689 LQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQS 748
Query: 895 ADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSV 954
A V+ YI + HDAFD YGV V+R++EGL++S +
Sbjct: 749 AHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAH------------------- 789
Query: 955 EYSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQ 1014
P+ + EDGK A+ + G + P + ++ +A+T
Sbjct: 790 ----------INPVFD-------PAEDGKEASARGARPSVSGALDPKALVKEE--QATTI 830
Query: 1015 FQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMAT 1074
FQ +QGK TID++WLFDDGGLTLLIPYLL K++W CKIRVF+GG+INR+D +R+A+ +
Sbjct: 831 FQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIIS 890
Query: 1075 LLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRI 1134
LLSKFR+ F ++ +L DIN P+ E+ FE++I P+RL++ K++ ++M+ D PW+I
Sbjct: 891 LLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKI 950
Query: 1135 TDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDL 1194
+D E+ + K+ RQ+RLNE++ ++S A +IV++LP+ RKG S+LYMAWLE LS+DL
Sbjct: 951 SDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDL 1010
Query: 1195 -PPILLVRGNHQSVLTFY 1211
PP++L+RGN ++VLTFY
Sbjct: 1011 RPPVILIRGNQENVLTFY 1028
>gi|186910317 solute carrier family 12, member 3 isoform 2 [Homo
sapiens]
Length = 1029
Score = 1072 bits (2773), Expect = 0.0
Identities = 535/1037 (51%), Positives = 727/1037 (70%), Gaps = 66/1037 (6%)
Query: 193 SGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEK 252
S H H TH++T+ +RTFG+NT+D VP +HY ++ + +RP+LA+LH L++
Sbjct: 39 SSHPSHL---THSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKE 95
Query: 253 --------------EPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLN 298
DG GE T + + V+FGW+KGV++RCMLN
Sbjct: 96 GRHLHALAFDSRPSHEMTDGLVEGEAGTSSEK-------NPEEPVRFGWVKGVMIRCMLN 148
Query: 299 IWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISR 358
IWGV+L++RL WI QAGI L+ ++I+++ VT+ITGLS SAI+TNG V+ GG Y+LISR
Sbjct: 149 IWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLISR 208
Query: 359 SLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVV 418
SLGPE GG+IGLIFAFANAV VAM+ VGFAETV +LL+E+ ++D INDIRIIG ++V
Sbjct: 209 SLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSVT 268
Query: 419 ILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIP-LESKKPKGFFGYKSEIFNENF 477
+LL IS+AGMEWE+KAQ++ ++++++ ++++GT IP E K KGFF Y+++IF +N
Sbjct: 269 VLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQNL 328
Query: 478 GPDFREEE-TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGI 536
PD+R + TFF +F+IFFP+ATGILAGANISGDL DP AIPKGTL+AI TT+ Y+ I
Sbjct: 329 VPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLAI 388
Query: 537 AVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSC-ESSPCSYGLMNNFQVMSM 595
+ ++GSCVVRDA+G +NDT+ C AC ++F+ C + C YGL+N +Q MSM
Sbjct: 389 SATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMSM 448
Query: 596 VSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGY 655
VSGF PLI+AGIF ATLSSALA LVSA K+FQ LC+D +YP F KGYGKN EP+RGY
Sbjct: 449 VSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRGY 508
Query: 656 ILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWI 715
+L + IA+ FI+IAELN IAPIISNFFL SYALINFS FHAS+ SPGWRP+F+YYN W
Sbjct: 509 LLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKWA 568
Query: 716 SLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSI 775
+L GAI+ ++MF++ WWAAL+ +VL L +YV YKKP+VNWGSS QA +Y AL +S+
Sbjct: 569 ALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYSV 628
Query: 776 RLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835
L+ VEDH+KN+RPQCLV+TG PN RPAL+ V FT+N+ LMICGHV +GP +Q M E+
Sbjct: 629 GLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPEL 688
Query: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895
+ + +WL K K+KAFY+ V A+DLR G Q LMQAAGLGRMKPN LV+GFKK+W A
Sbjct: 689 QLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQSA 748
Query: 896 DMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVE 955
V+ YI + HDAFD YGV V+R++EGL++S +
Sbjct: 749 HPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAH-------------------- 788
Query: 956 YSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQF 1015
P+ + EDGK A+ + G + P + ++ +A+T F
Sbjct: 789 ---------INPVFD-------PAEDGKEASARGARPSVSGALDPKALVKEE--QATTIF 830
Query: 1016 QKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATL 1075
Q +QGK TID++WLFDDGGLTLLIPYLL K++W CKIRVF+GG+INR+D +R+A+ +L
Sbjct: 831 QSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISL 890
Query: 1076 LSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRIT 1135
LSKFR+ F ++ +L DIN P+ E+ FE++I P+RL++ K++ ++M+ D PW+I+
Sbjct: 891 LSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKIS 950
Query: 1136 DNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDL- 1194
D E+ + K+ RQ+RLNE++ ++S A +IV++LP+ RKG S+LYMAWLE LS+DL
Sbjct: 951 DEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLR 1010
Query: 1195 PPILLVRGNHQSVLTFY 1211
PP++L+RGN ++VLTFY
Sbjct: 1011 PPVILIRGNQENVLTFY 1027
>gi|186910319 solute carrier family 12, member 3 isoform 3 [Homo
sapiens]
Length = 1021
Score = 1068 bits (2762), Expect = 0.0
Identities = 537/1038 (51%), Positives = 725/1038 (69%), Gaps = 76/1038 (7%)
Query: 193 SGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEK 252
S H H TH++T+ +RTFG+NT+D VP +HY ++ + +RP+LA+LH L++
Sbjct: 39 SSHPSHL---THSSTFCMRTFGYNTIDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQ 95
Query: 253 E---------------PFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCML 297
E DG GE T + + V+FGW+KGV++RCML
Sbjct: 96 EGRHLHALAFDSRPSHEMTDGLVEGEAGTSSEK-------NPEEPVRFGWVKGVMIRCML 148
Query: 298 NIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLIS 357
NIWGV+L++RL WI QAGI L+ ++I+++ VT+ITGLS SAI+TNG V+ GG Y+LIS
Sbjct: 149 NIWGVILYLRLPWITAQAGIVLTWIIILLSVTVTSITGLSISAISTNGKVKSGGTYFLIS 208
Query: 358 RSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITV 417
RSLGPE GG+IGLIFAFANAV VAM+ VGFAETV +LL+E+ ++D INDIRIIG ++V
Sbjct: 209 RSLGPELGGSIGLIFAFANAVGVAMHTVGFAETVRDLLQEYGAPIVDPINDIRIIGVVSV 268
Query: 418 VILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIP-LESKKPKGFFGYKSEIFNEN 476
+LL IS+AGMEWE+KAQ++ ++++++ ++++GT IP E K KGFF Y+++IF +N
Sbjct: 269 TVLLAISLAGMEWESKAQVLFFLVIMVSFANYLVGTLIPPSEDKASKGFFSYRADIFVQN 328
Query: 477 FGPDFREEE-TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVG 535
PD+R + TFF +F+IFFP+ATGILAGANISGDL DP AIPKGTL+AI TT+ Y+
Sbjct: 329 LVPDWRGPDGTFFGMFSIFFPSATGILAGANISGDLKDPAIAIPKGTLMAIFWTTISYLA 388
Query: 536 IAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSC-ESSPCSYGLMNNFQVMS 594
I+ ++GSCVVRDA+G +NDT+ C AC ++F+ C + C YGL+N +Q MS
Sbjct: 389 ISATIGSCVVRDASGVLNDTVTPGWGACEGLACSYGWNFTECTQQHSCHYGLINYYQTMS 448
Query: 595 MVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRG 654
MVSGF PLI+AGIF ATLSSALA LVSA K+FQ LC+D +YP F KGYGKN EP+RG
Sbjct: 449 MVSGFAPLITAGIFGATLSSALACLVSAAKVFQCLCEDQLYPLIGFFGKGYGKNKEPVRG 508
Query: 655 YILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMW 714
Y+L + IA+ FI+IAELN IAPIISNFFL SYALINFS FHAS+ SPGWRP+F+YYN W
Sbjct: 509 YLLAYAIAVAFIIIAELNTIAPIISNFFLCSYALINFSCFHASITNSPGWRPSFQYYNKW 568
Query: 715 ISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHS 774
+L GAI+ ++MF++ WWAAL+ +VL L +YV YKKP+VNWGSS QA +Y AL +S
Sbjct: 569 AALFGAIISVVIMFLLTWWAALIAIGVVLFLLLYVIYKKPEVNWGSSVQAGSYNLALSYS 628
Query: 775 IRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKE 834
+ L+ VEDH+KN+RPQCLV+TG PN RPAL+ V FT+N+ LMICGHV +GP +Q M E
Sbjct: 629 VGLNEVEDHIKNYRPQCLVLTGPPNFRPALVDFVGTFTRNLSLMICGHVLIGPHKQRMPE 688
Query: 835 MSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQ 894
+ + + +WL K K+KAFY+ V A+DLR G Q LMQAAGLGRMKPN LV+GFKK+W
Sbjct: 689 LQLIANGHTKWLNKRKIKAFYSDVIAEDLRRGVQILMQAAGLGRMKPNILVVGFKKNWQS 748
Query: 895 ADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSV 954
A V+ YI + HDAFD YGV V+R++EGL++S +
Sbjct: 749 AHPATVEDYIGILHDAFDFNYGVCVMRMREGLNVSKMMQAH------------------- 789
Query: 955 EYSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQ 1014
P+ + EDGK A+ + K A K +A+T
Sbjct: 790 ----------INPVFD-------PAEDGKEASARVDPK-----------ALVKEEQATTI 821
Query: 1015 FQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMAT 1074
FQ +QGK TID++WLFDDGGLTLLIPYLL K++W CKIRVF+GG+INR+D +R+A+ +
Sbjct: 822 FQSEQGKKTIDIYWLFDDGGLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIIS 881
Query: 1075 LLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRI 1134
LLSKFR+ F ++ +L DIN P+ E+ FE++I P+RL++ K++ ++M+ D PW+I
Sbjct: 882 LLSKFRLGFHEVHILPDINQNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKI 941
Query: 1135 TDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDL 1194
+D E+ + K+ RQ+RLNE++ ++S A +IV++LP+ RKG S+LYMAWLE LS+DL
Sbjct: 942 SDEEITKNRVKSLRQVRLNEIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDL 1001
Query: 1195 -PPILLVRGNHQSVLTFY 1211
PP++L+RGN ++VLTFY
Sbjct: 1002 RPPVILIRGNQENVLTFY 1019
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 286 bits (732), Expect = 8e-77
Identities = 192/640 (30%), Positives = 334/640 (52%), Gaps = 73/640 (11%)
Query: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
K GV+V +L+++ +++F+R+ ++VG AG+ ++ ++++A + +T LS AIAT
Sbjct: 36 KLSTFLGVVVPTVLSMFSIVVFLRIGFVVGHAGLLQALAMLLVAYFILALTVLSVCAIAT 95
Query: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSI--- 400
NG V+GGGAY++ISR+LGPE GG+IGL+F AN A+ ++G E+V+++ +
Sbjct: 96 NGAVQGGGAYFMISRTLGPEVGGSIGLMFYLANVCGCAVSLLGLVESVLDVFGADATGPS 155
Query: 401 ---LMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPL 457
++ + G++ + ++ G+ G A+A + +++ ++ +I +F+ +
Sbjct: 156 GLRVLPQGYGWNLLYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLI-SFVAV 214
Query: 458 ESKK--------PKG---------FFGYKSEIFNENFGPDFREEET------FFSVFAIF 494
+ P G F G+ S +N G + E+ T F SVFA+
Sbjct: 215 GPRDIRLTPRPGPNGSSLPPRFGHFTGFNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVL 274
Query: 495 FPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVND 554
F TGI+AGAN+SG+L DP AIP GT++A+ T VYV
Sbjct: 275 FNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYV-------------------- 314
Query: 555 TIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSS 614
++ L++ T L D YG F+ +S+ + PL+ GI++ LS+
Sbjct: 315 -LLFFLSSFTCDRTLLQED----------YGF---FRAISL---WPPLVLIGIYATALSA 357
Query: 615 ALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVI 674
+++SL+ A +I AL +D+++ AK + P + ++ + +L +LN +
Sbjct: 358 SMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWAAVLYSWGLVQLVLLAGKLNTL 417
Query: 675 APIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWA 734
A +++ F+L +YA ++ S A +P +RP F ++ LLG C ++MF+I+ A
Sbjct: 418 AAVVTVFYLVAYAAVDLSCLSLEWASAPNFRPTFSLFSWHTCLLGVASCLLMMFLISPGA 477
Query: 735 ALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVM 794
A + +++ L +T + +WG +QAL + ++ +RL +DHVK +RPQ L++
Sbjct: 478 AGGSLLLMGLLAALLTARGGPSSWGYVSQALLFHQVRKYLLRLDVRKDHVKFWRPQLLLL 537
Query: 795 TGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLI---KNKM 851
G P LL L + K GL + GHV +G + Q +Y WL + ++
Sbjct: 538 VGNPRGALPLLRLANQLKKG-GLYVLGHVTLGDLDSLPSDPV--QPQYGAWLSLVDRAQV 594
Query: 852 KAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKD 891
KAF + +R+GAQ+L++ +GLG MKPNTLVLGF D
Sbjct: 595 KAFVDLTLSPSVRQGAQHLLRISGLGGMKPNTLVLGFYDD 634
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 254 bits (650), Expect = 3e-67
Identities = 139/416 (33%), Positives = 226/416 (54%), Gaps = 45/416 (10%)
Query: 283 VKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIA 342
V FG GV CM+NI+GV+LF+R W+VG G+ L + ++ +V +T LS +
Sbjct: 37 VLFGTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVG 96
Query: 343 TNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILM 402
+ GG Y +IS LG + GG IGL++ F VA AMY+ GFAE++ +LL
Sbjct: 97 ERSSIGSGGVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITGFAESISDLLG------ 150
Query: 403 IDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKP 462
+ I +R I ++ LLGI++AG++W + Q++LL +L ++ DFV+G+F L+ +
Sbjct: 151 LGNIWAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPE-- 208
Query: 463 KGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGT 522
GF GY E+ N PD+ E+FF+VF +FFPAATG++AG N+ GDL +P ++IP G+
Sbjct: 209 HGFIGYSPELLQNNTLPDYSPGESFFTVFGVFFPAATGVMAGFNMGGDLREPAASIPLGS 268
Query: 523 LLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPC 582
L A+ I+ +Y+ +G+ R+A L +DF E
Sbjct: 269 LAAVGISWFLYIVFVFLLGAICTREA---------------------LRYDFLIAEK--- 304
Query: 583 SYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFA 642
VS L G++ ++L+S + L AP+I Q + ++ + PA
Sbjct: 305 -------------VSLMGFLFLLGLYISSLASCMGGLYGAPRILQCIAQEKVIPALACLG 351
Query: 643 KGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASL 698
+G G N P+ LT L+ + F+ + ++NV+API++ F+ +Y +++S F S+
Sbjct: 352 QGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYVAVDYSYFSLSM 407
Score = 45.1 bits (105), Expect = 4e-04
Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 4/63 (6%)
Query: 704 WRPAFKYY----NMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWG 759
WR + +Y N W+SLLGA+ ++MFVI W L+ + +Y Y+ P ++ G
Sbjct: 582 WRRSTSFYTHMCNPWVSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYIGRASPGLHLG 641
Query: 760 SST 762
S++
Sbjct: 642 SAS 644
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 231 bits (588), Expect = 4e-60
Identities = 148/420 (35%), Positives = 214/420 (50%), Gaps = 44/420 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI+ T+LVY V G+C
Sbjct: 388 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 447
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ G+ N V ++
Sbjct: 448 GVVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPW 474
Query: 602 LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTFL 660
+I G F +T + L SL AP++ QA+ KDNI P ++F G+GK N EP +LT L
Sbjct: 475 VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTAL 532
Query: 661 IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA 720
IA ILIA L+++API+S FFL Y +N + +L ++P WRP FKYY+ +S LG
Sbjct: 533 IAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGM 592
Query: 721 ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV 780
LC +MFV +W+ AL+ +I +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 593 SLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEG 652
Query: 781 EDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMS 836
H KN+RPQ LV+ P LL GL I G V G ++ E
Sbjct: 653 PPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQ 712
Query: 837 IDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQAD 896
+ + + K+K F V A +REG +L+Q+ GLG M+ N++VLG+ W Q++
Sbjct: 713 AAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSE 772
Score = 130 bits (326), Expect = 1e-29
Identities = 76/239 (31%), Positives = 131/239 (54%), Gaps = 13/239 (5%)
Query: 218 MDAVPRIDHYRHTAAQLGEKL-LRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYT 276
++A ID+Y A E+L +RP ++ L +L A E + +
Sbjct: 22 LEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRA 81
Query: 277 AESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGL 336
AE+ + G + GV + C+ NI+GV+LF+RL+W+VG AG+ ++L++++ T +T +
Sbjct: 82 AEAPSM---GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAI 138
Query: 337 STSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLK 396
S SAIATNG V GG+Y++ISRSLGPEFGGA+GL F A AMY++G E ++ +
Sbjct: 139 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIA 198
Query: 397 EHSILMIDE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
+ + +N++R+ G I + + + G+++ K + L ++++I
Sbjct: 199 PPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISI 257
Score = 74.3 bits (181), Expect = 6e-13
Identities = 58/242 (23%), Positives = 113/242 (46%), Gaps = 55/242 (22%)
Query: 1024 IDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSKFRI 1081
IDVWW+ DGG+ +L+P+LL K W+ C++R+F ++ N I ++ +A L R+
Sbjct: 815 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQM-KKDLAVFLYHLRL 873
Query: 1082 DFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDI------------- 1122
+ +++ V+ DI+ + ++ + +++ RL + ++E++
Sbjct: 874 E-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLE 932
Query: 1123 -------------ADKMKED-----------EPWRITDNELELYKTK--------TYRQI 1150
ADK++ +P DN EL K + +
Sbjct: 933 SLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAV 992
Query: 1151 RLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTF 1210
+LNE++ S A ++++++P + + YM +LE L++ L +LLVRG + V+T
Sbjct: 993 KLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITI 1052
Query: 1211 YS 1212
YS
Sbjct: 1053 YS 1054
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 231 bits (588), Expect = 4e-60
Identities = 148/420 (35%), Positives = 214/420 (50%), Gaps = 44/420 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI+ T+LVY V G+C
Sbjct: 413 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 472
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ G+ N V ++
Sbjct: 473 GVVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPW 499
Query: 602 LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTFL 660
+I G F +T + L SL AP++ QA+ KDNI P ++F G+GK N EP +LT L
Sbjct: 500 VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTAL 557
Query: 661 IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA 720
IA ILIA L+++API+S FFL Y +N + +L ++P WRP FKYY+ +S LG
Sbjct: 558 IAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGM 617
Query: 721 ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV 780
LC +MFV +W+ AL+ +I +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 618 SLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEG 677
Query: 781 EDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMS 836
H KN+RPQ LV+ P LL GL I G V G ++ E
Sbjct: 678 PPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQ 737
Query: 837 IDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQAD 896
+ + + K+K F V A +REG +L+Q+ GLG M+ N++VLG+ W Q++
Sbjct: 738 AAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSE 797
Score = 130 bits (326), Expect = 1e-29
Identities = 76/239 (31%), Positives = 131/239 (54%), Gaps = 13/239 (5%)
Query: 218 MDAVPRIDHYRHTAAQLGEKL-LRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYT 276
++A ID+Y A E+L +RP ++ L +L A E + +
Sbjct: 47 LEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRA 106
Query: 277 AESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGL 336
AE+ + G + GV + C+ NI+GV+LF+RL+W+VG AG+ ++L++++ T +T +
Sbjct: 107 AEAPSM---GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAI 163
Query: 337 STSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLK 396
S SAIATNG V GG+Y++ISRSLGPEFGGA+GL F A AMY++G E ++ +
Sbjct: 164 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIA 223
Query: 397 EHSILMIDE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
+ + +N++R+ G I + + + G+++ K + L ++++I
Sbjct: 224 PPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISI 282
Score = 74.3 bits (181), Expect = 6e-13
Identities = 58/242 (23%), Positives = 113/242 (46%), Gaps = 55/242 (22%)
Query: 1024 IDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSKFRI 1081
IDVWW+ DGG+ +L+P+LL K W+ C++R+F ++ N I ++ +A L R+
Sbjct: 840 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQM-KKDLAVFLYHLRL 898
Query: 1082 DFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDI------------- 1122
+ +++ V+ DI+ + ++ + +++ RL + ++E++
Sbjct: 899 E-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLE 957
Query: 1123 -------------ADKMKED-----------EPWRITDNELELYKTK--------TYRQI 1150
ADK++ +P DN EL K + +
Sbjct: 958 SLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAV 1017
Query: 1151 RLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTF 1210
+LNE++ S A ++++++P + + YM +LE L++ L +LLVRG + V+T
Sbjct: 1018 KLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITI 1077
Query: 1211 YS 1212
YS
Sbjct: 1078 YS 1079
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 231 bits (588), Expect = 4e-60
Identities = 148/420 (35%), Positives = 214/420 (50%), Gaps = 44/420 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI+ T+LVY V G+C
Sbjct: 421 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 480
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ G+ N V ++
Sbjct: 481 GVVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPW 507
Query: 602 LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTFL 660
+I G F +T + L SL AP++ QA+ KDNI P ++F G+GK N EP +LT L
Sbjct: 508 VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTAL 565
Query: 661 IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA 720
IA ILIA L+++API+S FFL Y +N + +L ++P WRP FKYY+ +S LG
Sbjct: 566 IAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGM 625
Query: 721 ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV 780
LC +MFV +W+ AL+ +I +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 626 SLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEG 685
Query: 781 EDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMS 836
H KN+RPQ LV+ P LL GL I G V G ++ E
Sbjct: 686 PPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQ 745
Query: 837 IDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQAD 896
+ + + K+K F V A +REG +L+Q+ GLG M+ N++VLG+ W Q++
Sbjct: 746 AAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSE 805
Score = 124 bits (310), Expect = 7e-28
Identities = 69/217 (31%), Positives = 120/217 (55%), Gaps = 12/217 (5%)
Query: 239 LRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLN 298
+RP ++ L +L A E + + AE+ + G + GV + C+ N
Sbjct: 77 IRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSM---GTLMGVYLPCLQN 133
Query: 299 IWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISR 358
I+GV+LF+RL+W+VG AG+ ++L++++ T +T +S SAIATNG V GG+Y++ISR
Sbjct: 134 IFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISR 193
Query: 359 SLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDE---------INDI 409
SLGPEFGGA+GL F A AMY++G E ++ + + + +N++
Sbjct: 194 SLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNM 253
Query: 410 RIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
R+ G I + + + G+++ K + L ++++I
Sbjct: 254 RVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISI 290
Score = 74.3 bits (181), Expect = 6e-13
Identities = 58/242 (23%), Positives = 113/242 (46%), Gaps = 55/242 (22%)
Query: 1024 IDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSKFRI 1081
IDVWW+ DGG+ +L+P+LL K W+ C++R+F ++ N I ++ +A L R+
Sbjct: 848 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQM-KKDLAVFLYHLRL 906
Query: 1082 DFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDI------------- 1122
+ +++ V+ DI+ + ++ + +++ RL + ++E++
Sbjct: 907 E-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLE 965
Query: 1123 -------------ADKMKED-----------EPWRITDNELELYKTK--------TYRQI 1150
ADK++ +P DN EL K + +
Sbjct: 966 SLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAV 1025
Query: 1151 RLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTF 1210
+LNE++ S A ++++++P + + YM +LE L++ L +LLVRG + V+T
Sbjct: 1026 KLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITI 1085
Query: 1211 YS 1212
YS
Sbjct: 1086 YS 1087
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 231 bits (588), Expect = 4e-60
Identities = 148/420 (35%), Positives = 214/420 (50%), Gaps = 44/420 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI+ T+LVY V G+C
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ G+ N V ++
Sbjct: 479 GVVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPW 505
Query: 602 LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTFL 660
+I G F +T + L SL AP++ QA+ KDNI P ++F G+GK N EP +LT L
Sbjct: 506 VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTAL 563
Query: 661 IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA 720
IA ILIA L+++API+S FFL Y +N + +L ++P WRP FKYY+ +S LG
Sbjct: 564 IAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGM 623
Query: 721 ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV 780
LC +MFV +W+ AL+ +I +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 624 SLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEG 683
Query: 781 EDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMS 836
H KN+RPQ LV+ P LL GL I G V G ++ E
Sbjct: 684 PPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQ 743
Query: 837 IDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQAD 896
+ + + K+K F V A +REG +L+Q+ GLG M+ N++VLG+ W Q++
Sbjct: 744 AAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSE 803
Score = 130 bits (326), Expect = 1e-29
Identities = 76/239 (31%), Positives = 131/239 (54%), Gaps = 13/239 (5%)
Query: 218 MDAVPRIDHYRHTAAQLGEKL-LRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYT 276
++A ID+Y A E+L +RP ++ L +L A E + +
Sbjct: 53 LEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRA 112
Query: 277 AESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGL 336
AE+ + G + GV + C+ NI+GV+LF+RL+W+VG AG+ ++L++++ T +T +
Sbjct: 113 AEAPSM---GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAI 169
Query: 337 STSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLK 396
S SAIATNG V GG+Y++ISRSLGPEFGGA+GL F A AMY++G E ++ +
Sbjct: 170 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIA 229
Query: 397 EHSILMIDE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
+ + +N++R+ G I + + + G+++ K + L ++++I
Sbjct: 230 PPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISI 288
Score = 74.7 bits (182), Expect = 5e-13
Identities = 56/234 (23%), Positives = 104/234 (44%), Gaps = 45/234 (19%)
Query: 1024 IDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKIN-------------------R 1064
IDVWW+ DGG+ +L+P+LL K W+ C++R+F +++
Sbjct: 846 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLE 905
Query: 1065 IDHDRRAMA-----TLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKE 1119
+H+ A TL+ + R M L + + + + + L+ D+++
Sbjct: 906 AEHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLESLYSDEED 965
Query: 1120 QDI--ADKMKED-----------EPWRITDNELELYKTK--------TYRQIRLNELLKE 1158
+ ADK++ +P DN EL K + ++LNE++
Sbjct: 966 ESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVT 1025
Query: 1159 HSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1212
S A ++++++P + + YM +LE L++ L +LLVRG + V+T YS
Sbjct: 1026 RSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1079
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 231 bits (588), Expect = 4e-60
Identities = 148/420 (35%), Positives = 214/420 (50%), Gaps = 44/420 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAI+ T+LVY V G+C
Sbjct: 419 SFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVVLFGACIE 478
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ G+ N V ++
Sbjct: 479 GVVLRDKYGD---------------------------------GVSRNLVVGTLAWPSPW 505
Query: 602 LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTFL 660
+I G F +T + L SL AP++ QA+ KDNI P ++F G+GK N EP +LT L
Sbjct: 506 VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHGKVNGEPTWALLLTAL 563
Query: 661 IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA 720
IA ILIA L+++API+S FFL Y +N + +L ++P WRP FKYY+ +S LG
Sbjct: 564 IAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGM 623
Query: 721 ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV 780
LC +MFV +W+ AL+ +I +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 624 SLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEG 683
Query: 781 EDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMS 836
H KN+RPQ LV+ P LL GL I G V G ++ E
Sbjct: 684 PPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQ 743
Query: 837 IDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQAD 896
+ + + K+K F V A +REG +L+Q+ GLG M+ N++VLG+ W Q++
Sbjct: 744 AAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSE 803
Score = 130 bits (326), Expect = 1e-29
Identities = 76/239 (31%), Positives = 131/239 (54%), Gaps = 13/239 (5%)
Query: 218 MDAVPRIDHYRHTAAQLGEKL-LRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYT 276
++A ID+Y A E+L +RP ++ L +L A E + +
Sbjct: 53 LEASRGIDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRA 112
Query: 277 AESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGL 336
AE+ + G + GV + C+ NI+GV+LF+RL+W+VG AG+ ++L++++ T +T +
Sbjct: 113 AEAPSM---GTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAI 169
Query: 337 STSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLK 396
S SAIATNG V GG+Y++ISRSLGPEFGGA+GL F A AMY++G E ++ +
Sbjct: 170 SMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIA 229
Query: 397 EHSILMIDE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
+ + +N++R+ G I + + + G+++ K + L ++++I
Sbjct: 230 PPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISI 288
Score = 74.3 bits (181), Expect = 6e-13
Identities = 58/242 (23%), Positives = 113/242 (46%), Gaps = 55/242 (22%)
Query: 1024 IDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSKFRI 1081
IDVWW+ DGG+ +L+P+LL K W+ C++R+F ++ N I ++ +A L R+
Sbjct: 846 IDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQM-KKDLAVFLYHLRL 904
Query: 1082 DFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDI------------- 1122
+ +++ V+ DI+ + ++ + +++ RL + ++E++
Sbjct: 905 E-AEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKDRHSALRLE 963
Query: 1123 -------------ADKMKED-----------EPWRITDNELELYKTK--------TYRQI 1150
ADK++ +P DN EL K + +
Sbjct: 964 SLYSDEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELVHIKPDQSNVRRMHTAV 1023
Query: 1151 RLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTF 1210
+LNE++ S A ++++++P + + YM +LE L++ L +LLVRG + V+T
Sbjct: 1024 KLNEVIVTRSHDARLVLLNMPGPPRNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITI 1083
Query: 1211 YS 1212
YS
Sbjct: 1084 YS 1085
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 223 bits (567), Expect = 1e-57
Identities = 147/421 (34%), Positives = 215/421 (51%), Gaps = 46/421 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAIL T+ VY+ V G+C
Sbjct: 469 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 528
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ A K N V+ +S +P
Sbjct: 529 GVVLRDKFGD---------------AVKGNL-------------------VVGTLSWPSP 554
Query: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659
+I G F +T + L SL AP++ QA+ KDNI P ++F G+ K N EP +LT
Sbjct: 555 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTA 612
Query: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
IA ILIA L+++API+S FFL Y +N + +L ++P WRP F+YY+ +S +G
Sbjct: 613 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 672
Query: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSG 779
+C +MF+ +W+ A++ VI +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 673 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 732
Query: 780 VEDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835
H KN+RPQ LV+ P LL GL I G V +G + E
Sbjct: 733 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 792
Query: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895
+ + + K+K F V A LREG +L+Q+ GLG MK NT+V+G+ W Q+
Sbjct: 793 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 852
Query: 896 D 896
+
Sbjct: 853 E 853
Score = 121 bits (303), Expect = 5e-27
Identities = 62/172 (36%), Positives = 106/172 (61%), Gaps = 9/172 (5%)
Query: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
+ G GV + C+ NI+GV+LF+RL+W+VG AG+ + ++++ T +T +S SAIAT
Sbjct: 169 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 228
Query: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAET-VVELLKEHSILM 402
NG V GG+Y++ISR+LGPEFGGA+GL F A AMY++G E +V ++ +I
Sbjct: 229 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFH 288
Query: 403 IDE--------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
D+ +N++R+ G +V+++ + G+ + K + L ++++I
Sbjct: 289 SDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSI 340
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 55/245 (22%)
Query: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
+ IDVWW+ DGG+ +L+P+LL K W+ C IR+F ++ N I ++ +AT L
Sbjct: 893 EGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQM-KKDLATFLYH 951
Query: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDIADKMKEDEPW 1132
RI+ +++ V+ DI+ + ++ + +++ RL + +++++ +
Sbjct: 952 LRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSML 1010
Query: 1133 RIT------DNELELYKTKT---------------------------------------Y 1147
R+T D E E Y+ K +
Sbjct: 1011 RLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMH 1070
Query: 1148 RQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSV 1207
++LNE++ S A ++++++P + YM +LE L++ L +LLVRG V
Sbjct: 1071 TAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEV 1130
Query: 1208 LTFYS 1212
+T YS
Sbjct: 1131 ITIYS 1135
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 223 bits (567), Expect = 1e-57
Identities = 147/421 (34%), Positives = 215/421 (51%), Gaps = 46/421 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAIL T+ VY+ V G+C
Sbjct: 475 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 534
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ A K N V+ +S +P
Sbjct: 535 GVVLRDKFGD---------------AVKGNL-------------------VVGTLSWPSP 560
Query: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659
+I G F +T + L SL AP++ QA+ KDNI P ++F G+ K N EP +LT
Sbjct: 561 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTA 618
Query: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
IA ILIA L+++API+S FFL Y +N + +L ++P WRP F+YY+ +S +G
Sbjct: 619 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 678
Query: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSG 779
+C +MF+ +W+ A++ VI +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 679 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 738
Query: 780 VEDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835
H KN+RPQ LV+ P LL GL I G V +G + E
Sbjct: 739 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 798
Query: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895
+ + + K+K F V A LREG +L+Q+ GLG MK NT+V+G+ W Q+
Sbjct: 799 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 858
Query: 896 D 896
+
Sbjct: 859 E 859
Score = 122 bits (307), Expect = 2e-27
Identities = 91/339 (26%), Positives = 161/339 (47%), Gaps = 43/339 (12%)
Query: 132 SEEAKGRFRVNFVDPAASSSAEDSLSDAAG-------VGVDGPNVSFQNGGDTV--LSEG 182
S + R R + + +S + +S+ +G V +D P+ + D + LS+
Sbjct: 27 SSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQN 86
Query: 183 SSLHSGGGGGSGHHQHYYYDTH--TNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKL-L 239
S +G H D H YL + D +++ A E++
Sbjct: 87 SI--------TGEHSQLLDDGHKKARNAYLNNSNYEEGD-----EYFDKNLALFEEEMDT 133
Query: 240 RPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVK---FGWIKGVLVRCM 296
RP ++ L + + + N + + T K K G GV + C+
Sbjct: 134 RPKVSSLLNRMAN------YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCL 187
Query: 297 LNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLI 356
NI+GV+LF+RL+W+VG AG+ + ++++ T +T +S SAIATNG V GG+Y++I
Sbjct: 188 QNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMI 247
Query: 357 SRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAET-VVELLKEHSILMIDE--------IN 407
SR+LGPEFGGA+GL F A AMY++G E +V ++ +I D+ +N
Sbjct: 248 SRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLN 307
Query: 408 DIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
++R+ G +V+++ + G+ + K + L ++++I
Sbjct: 308 NMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSI 346
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 55/245 (22%)
Query: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
+ IDVWW+ DGG+ +L+P+LL K W+ C IR+F ++ N I ++ +AT L
Sbjct: 899 EGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQM-KKDLATFLYH 957
Query: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDIADKMKEDEPW 1132
RI+ +++ V+ DI+ + ++ + +++ RL + +++++ +
Sbjct: 958 LRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSML 1016
Query: 1133 RIT------DNELELYKTKT---------------------------------------Y 1147
R+T D E E Y+ K +
Sbjct: 1017 RLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMH 1076
Query: 1148 RQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSV 1207
++LNE++ S A ++++++P + YM +LE L++ L +LLVRG V
Sbjct: 1077 TAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEV 1136
Query: 1208 LTFYS 1212
+T YS
Sbjct: 1137 ITIYS 1141
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 223 bits (567), Expect = 1e-57
Identities = 147/421 (34%), Positives = 215/421 (51%), Gaps = 46/421 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAIL T+ VY+ V G+C
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ A K N V+ +S +P
Sbjct: 485 GVVLRDKFGD---------------AVKGNL-------------------VVGTLSWPSP 510
Query: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659
+I G F +T + L SL AP++ QA+ KDNI P ++F G+ K N EP +LT
Sbjct: 511 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTA 568
Query: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
IA ILIA L+++API+S FFL Y +N + +L ++P WRP F+YY+ +S +G
Sbjct: 569 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 628
Query: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSG 779
+C +MF+ +W+ A++ VI +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 629 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 688
Query: 780 VEDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835
H KN+RPQ LV+ P LL GL I G V +G + E
Sbjct: 689 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 748
Query: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895
+ + + K+K F V A LREG +L+Q+ GLG MK NT+V+G+ W Q+
Sbjct: 749 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 808
Query: 896 D 896
+
Sbjct: 809 E 809
Score = 121 bits (303), Expect = 5e-27
Identities = 62/172 (36%), Positives = 106/172 (61%), Gaps = 9/172 (5%)
Query: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
+ G GV + C+ NI+GV+LF+RL+W+VG AG+ + ++++ T +T +S SAIAT
Sbjct: 125 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 184
Query: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAET-VVELLKEHSILM 402
NG V GG+Y++ISR+LGPEFGGA+GL F A AMY++G E +V ++ +I
Sbjct: 185 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFH 244
Query: 403 IDE--------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
D+ +N++R+ G +V+++ + G+ + K + L ++++I
Sbjct: 245 SDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSI 296
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 55/245 (22%)
Query: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
+ IDVWW+ DGG+ +L+P+LL K W+ C IR+F ++ N I ++ +AT L
Sbjct: 849 EGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQM-KKDLATFLYH 907
Query: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDIADKMKEDEPW 1132
RI+ +++ V+ DI+ + ++ + +++ RL + +++++ +
Sbjct: 908 LRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSML 966
Query: 1133 RIT------DNELELYKTKT---------------------------------------Y 1147
R+T D E E Y+ K +
Sbjct: 967 RLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMH 1026
Query: 1148 RQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSV 1207
++LNE++ S A ++++++P + YM +LE L++ L +LLVRG V
Sbjct: 1027 TAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEV 1086
Query: 1208 LTFYS 1212
+T YS
Sbjct: 1087 ITIYS 1091
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 223 bits (567), Expect = 1e-57
Identities = 147/421 (34%), Positives = 215/421 (51%), Gaps = 46/421 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAIL T+ VY+ V G+C
Sbjct: 425 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 484
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ A K N V+ +S +P
Sbjct: 485 GVVLRDKFGD---------------AVKGNL-------------------VVGTLSWPSP 510
Query: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659
+I G F +T + L SL AP++ QA+ KDNI P ++F G+ K N EP +LT
Sbjct: 511 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTA 568
Query: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
IA ILIA L+++API+S FFL Y +N + +L ++P WRP F+YY+ +S +G
Sbjct: 569 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 628
Query: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSG 779
+C +MF+ +W+ A++ VI +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 629 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 688
Query: 780 VEDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835
H KN+RPQ LV+ P LL GL I G V +G + E
Sbjct: 689 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 748
Query: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895
+ + + K+K F V A LREG +L+Q+ GLG MK NT+V+G+ W Q+
Sbjct: 749 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 808
Query: 896 D 896
+
Sbjct: 809 E 809
Score = 121 bits (303), Expect = 5e-27
Identities = 62/172 (36%), Positives = 106/172 (61%), Gaps = 9/172 (5%)
Query: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
+ G GV + C+ NI+GV+LF+RL+W+VG AG+ + ++++ T +T +S SAIAT
Sbjct: 125 QMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIAT 184
Query: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAET-VVELLKEHSILM 402
NG V GG+Y++ISR+LGPEFGGA+GL F A AMY++G E +V ++ +I
Sbjct: 185 NGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFH 244
Query: 403 IDE--------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
D+ +N++R+ G +V+++ + G+ + K + L ++++I
Sbjct: 245 SDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSI 296
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 55/245 (22%)
Query: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
+ IDVWW+ DGG+ +L+P+LL K W+ C IR+F ++ N I ++ +AT L
Sbjct: 849 EGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQM-KKDLATFLYH 907
Query: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDIADKMKEDEPW 1132
RI+ +++ V+ DI+ + ++ + +++ RL + +++++ +
Sbjct: 908 LRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSML 966
Query: 1133 RIT------DNELELYKTKT---------------------------------------Y 1147
R+T D E E Y+ K +
Sbjct: 967 RLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMH 1026
Query: 1148 RQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSV 1207
++LNE++ S A ++++++P + YM +LE L++ L +LLVRG V
Sbjct: 1027 TAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEV 1086
Query: 1208 LTFYS 1212
+T YS
Sbjct: 1087 ITIYS 1091
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 223 bits (567), Expect = 1e-57
Identities = 147/421 (34%), Positives = 215/421 (51%), Gaps = 46/421 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAIL T+ VY+ V G+C
Sbjct: 433 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 492
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ A K N V+ +S +P
Sbjct: 493 GVVLRDKFGD---------------AVKGNL-------------------VVGTLSWPSP 518
Query: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659
+I G F +T + L SL AP++ QA+ KDNI P ++F G+ K N EP +LT
Sbjct: 519 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTA 576
Query: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
IA ILIA L+++API+S FFL Y +N + +L ++P WRP F+YY+ +S +G
Sbjct: 577 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 636
Query: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSG 779
+C +MF+ +W+ A++ VI +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 637 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 696
Query: 780 VEDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835
H KN+RPQ LV+ P LL GL I G V +G + E
Sbjct: 697 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 756
Query: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895
+ + + K+K F V A LREG +L+Q+ GLG MK NT+V+G+ W Q+
Sbjct: 757 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 816
Query: 896 D 896
+
Sbjct: 817 E 817
Score = 122 bits (307), Expect = 2e-27
Identities = 90/315 (28%), Positives = 151/315 (47%), Gaps = 42/315 (13%)
Query: 147 AASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTH-- 204
AAS S E SL+D Q+ + LS+ S +G H D H
Sbjct: 17 AASISQEPSLADI--------KARIQDSDEPDLSQNSI--------TGEHSQLLDDGHKK 60
Query: 205 TNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKL-LRPSLAELHDELEKEPFEDGFANGE 263
YL + D +++ A E++ RP ++ L + + + N
Sbjct: 61 ARNAYLNNSNYEEGD-----EYFDKNLALFEEEMDTRPKVSSLLNRMAN------YTNLT 109
Query: 264 ESTPTRDAVVTYTAESKGVVK---FGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLS 320
+ + T K K G GV + C+ NI+GV+LF+RL+W+VG AG+ +
Sbjct: 110 QGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQA 169
Query: 321 VLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAV 380
++++ T +T +S SAIATNG V GG+Y++ISR+LGPEFGGA+GL F A
Sbjct: 170 FAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAA 229
Query: 381 AMYVVGFAET-VVELLKEHSILMIDE--------INDIRIIGAITVVILLGISVAGMEWE 431
AMY++G E +V ++ +I D+ +N++R+ G +V+++ + G+ +
Sbjct: 230 AMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYV 289
Query: 432 AKAQIVLLVILLLAI 446
K + L ++++I
Sbjct: 290 NKFASLFLACVIVSI 304
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 55/245 (22%)
Query: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
+ IDVWW+ DGG+ +L+P+LL K W+ C IR+F ++ N I ++ +AT L
Sbjct: 857 EGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQM-KKDLATFLYH 915
Query: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDIADKMKEDEPW 1132
RI+ +++ V+ DI+ + ++ + +++ RL + +++++ +
Sbjct: 916 LRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSML 974
Query: 1133 RIT------DNELELYKTKT---------------------------------------Y 1147
R+T D E E Y+ K +
Sbjct: 975 RLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMH 1034
Query: 1148 RQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSV 1207
++LNE++ S A ++++++P + YM +LE L++ L +LLVRG V
Sbjct: 1035 TAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEV 1094
Query: 1208 LTFYS 1212
+T YS
Sbjct: 1095 ITIYS 1099
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 223 bits (567), Expect = 1e-57
Identities = 147/421 (34%), Positives = 215/421 (51%), Gaps = 46/421 (10%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + IFFP+ TGI+AG+N SGDL D Q +IP GT+LAIL T+ VY+ V G+C
Sbjct: 484 SFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLFGACIE 543
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G+ A K N V+ +S +P
Sbjct: 544 GVVLRDKFGD---------------AVKGNL-------------------VVGTLSWPSP 569
Query: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659
+I G F +T + L SL AP++ QA+ KDNI P ++F G+ K N EP +LT
Sbjct: 570 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVF--GHSKANGEPTWALLLTA 627
Query: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
IA ILIA L+++API+S FFL Y +N + +L ++P WRP F+YY+ +S +G
Sbjct: 628 AIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTPNWRPRFRYYHWALSFMG 687
Query: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSG 779
+C +MF+ +W+ A++ VI +Y Y+ Y+ + WG + L+ A +RL
Sbjct: 688 MSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEE 747
Query: 780 VEDHVKNFRPQCLVMTGAPN----SRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEM 835
H KN+RPQ LV+ P LL GL I G V +G + E
Sbjct: 748 GPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEA 807
Query: 836 SIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQA 895
+ + + K+K F V A LREG +L+Q+ GLG MK NT+V+G+ W Q+
Sbjct: 808 LAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQS 867
Query: 896 D 896
+
Sbjct: 868 E 868
Score = 122 bits (307), Expect = 2e-27
Identities = 91/339 (26%), Positives = 161/339 (47%), Gaps = 43/339 (12%)
Query: 132 SEEAKGRFRVNFVDPAASSSAEDSLSDAAG-------VGVDGPNVSFQNGGDTV--LSEG 182
S + R R + + +S + +S+ +G V +D P+ + D + LS+
Sbjct: 36 SSRSSSRVRFSSRESVPETSRSEPMSEMSGATTSLATVALDPPSDRTSHPQDVIEDLSQN 95
Query: 183 SSLHSGGGGGSGHHQHYYYDTH--TNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKL-L 239
S +G H D H YL + D +++ A E++
Sbjct: 96 SI--------TGEHSQLLDDGHKKARNAYLNNSNYEEGD-----EYFDKNLALFEEEMDT 142
Query: 240 RPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVK---FGWIKGVLVRCM 296
RP ++ L + + + N + + T K K G GV + C+
Sbjct: 143 RPKVSSLLNRMAN------YTNLTQGAKEHEEAENITEGKKKPTKTPQMGTFMGVYLPCL 196
Query: 297 LNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLI 356
NI+GV+LF+RL+W+VG AG+ + ++++ T +T +S SAIATNG V GG+Y++I
Sbjct: 197 QNIFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMI 256
Query: 357 SRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAET-VVELLKEHSILMIDE--------IN 407
SR+LGPEFGGA+GL F A AMY++G E +V ++ +I D+ +N
Sbjct: 257 SRALGPEFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLN 316
Query: 408 DIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
++R+ G +V+++ + G+ + K + L ++++I
Sbjct: 317 NMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSI 355
Score = 76.6 bits (187), Expect = 1e-13
Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 55/245 (22%)
Query: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
+ IDVWW+ DGG+ +L+P+LL K W+ C IR+F ++ N I ++ +AT L
Sbjct: 908 EGNIDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQM-KKDLATFLYH 966
Query: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDIADKMKEDEPW 1132
RI+ +++ V+ DI+ + ++ + +++ RL + +++++ +
Sbjct: 967 LRIE-AEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKDRNSML 1025
Query: 1133 RIT------DNELELYKTKT---------------------------------------Y 1147
R+T D E E Y+ K +
Sbjct: 1026 RLTSIGSDEDEETETYQEKVHMTWTKDKYMASRGQKAKSMEGFQDLLNMRPDQSNVRRMH 1085
Query: 1148 RQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSV 1207
++LNE++ S A ++++++P + YM +LE L++ L +LLVRG V
Sbjct: 1086 TAVKLNEVIVNKSHEAKLVLLNMPGPPRNPEGDENYMEFLEVLTEGLERVLLVRGGGSEV 1145
Query: 1208 LTFYS 1212
+T YS
Sbjct: 1146 ITIYS 1150
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 221 bits (563), Expect = 3e-57
Identities = 140/427 (32%), Positives = 218/427 (51%), Gaps = 47/427 (11%)
Query: 481 FREEETFFSVFA-IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVS 539
F + ++F++ I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI T+ VY+ V
Sbjct: 416 FSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVL 475
Query: 540 VGSC----VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSM 595
G+C V+RD G +N V+
Sbjct: 476 FGACIEGVVLRDKFGEA----------------------------------VNGNLVVGT 501
Query: 596 VSGFTP-LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLR 653
++ +P +I G F +T + L SL AP++ QA+ +D I P Q+F G+GK N EP
Sbjct: 502 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVF--GHGKANGEPTW 559
Query: 654 GYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNM 713
+LT I ILIA L+ +API+S FFL Y +N + +L ++P WRP F+YY+
Sbjct: 560 ALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHW 619
Query: 714 WISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQH 773
+S LG LC +MF+ +W+ AL+ +I +Y Y+ Y+ + WG + L+ A
Sbjct: 620 TLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYA 679
Query: 774 SIRLSGVEDHVKNFRPQCLVMTGAPNSR----PALLHLVHDFTKNVGLMICGHVHMGPRR 829
+RL H KN+RPQ LV+ + P LL L GL I G V G
Sbjct: 680 LLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFL 739
Query: 830 QAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFK 889
+ + + +R + K+K F V + +LR+G +L+Q+ GLG ++ NT+++G+
Sbjct: 740 ENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWP 799
Query: 890 KDWLQAD 896
++W Q +
Sbjct: 800 RNWRQKE 806
Score = 122 bits (306), Expect = 2e-27
Identities = 66/172 (38%), Positives = 101/172 (58%), Gaps = 9/172 (5%)
Query: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
+ G GV + C+ NI+GV+LF+RL+W+VG AGI S ++ + T +T +S SAIAT
Sbjct: 119 RMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIAT 178
Query: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMI 403
NG V GG+YY+ISRSLGPEFGGA+GL F A AMY++G E ++ L +
Sbjct: 179 NGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFK 238
Query: 404 DE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
E +N++R+ G + + + G+++ K +V L ++L+I
Sbjct: 239 AEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSI 290
Score = 53.9 bits (128), Expect = 9e-07
Identities = 31/110 (28%), Positives = 65/110 (59%), Gaps = 10/110 (9%)
Query: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
+ +IDVWW+ DGG+ +L+P+LL K W+ CK+R+F ++ N I ++ + T L
Sbjct: 846 EGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQM-KKDLTTFLYH 904
Query: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDI 1122
RI +++ V+ DI+ ++ ++ + +I++ L ++++E++I
Sbjct: 905 LRIT-AEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREI 953
Score = 46.6 bits (109), Expect = 1e-04
Identities = 21/68 (30%), Positives = 41/68 (60%)
Query: 1145 KTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNH 1204
+ + +RLNE++ + S A ++++++P + YM +LE L++ L ++LVRG
Sbjct: 1072 RMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGG 1131
Query: 1205 QSVLTFYS 1212
+ V+T YS
Sbjct: 1132 REVITIYS 1139
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 221 bits (563), Expect = 3e-57
Identities = 140/427 (32%), Positives = 218/427 (51%), Gaps = 47/427 (11%)
Query: 481 FREEETFFSVFA-IFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVS 539
F + ++F++ I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI T+ VY+ V
Sbjct: 393 FSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVL 452
Query: 540 VGSC----VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSM 595
G+C V+RD G +N V+
Sbjct: 453 FGACIEGVVLRDKFGEA----------------------------------VNGNLVVGT 478
Query: 596 VSGFTP-LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLR 653
++ +P +I G F +T + L SL AP++ QA+ +D I P Q+F G+GK N EP
Sbjct: 479 LAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVF--GHGKANGEPTW 536
Query: 654 GYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNM 713
+LT I ILIA L+ +API+S FFL Y +N + +L ++P WRP F+YY+
Sbjct: 537 ALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHW 596
Query: 714 WISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQH 773
+S LG LC +MF+ +W+ AL+ +I +Y Y+ Y+ + WG + L+ A
Sbjct: 597 TLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYA 656
Query: 774 SIRLSGVEDHVKNFRPQCLVMTGAPNSR----PALLHLVHDFTKNVGLMICGHVHMGPRR 829
+RL H KN+RPQ LV+ + P LL L GL I G V G
Sbjct: 657 LLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFL 716
Query: 830 QAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFK 889
+ + + +R + K+K F V + +LR+G +L+Q+ GLG ++ NT+++G+
Sbjct: 717 ENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWP 776
Query: 890 KDWLQAD 896
++W Q +
Sbjct: 777 RNWRQKE 783
Score = 122 bits (306), Expect = 2e-27
Identities = 66/172 (38%), Positives = 101/172 (58%), Gaps = 9/172 (5%)
Query: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
+ G GV + C+ NI+GV+LF+RL+W+VG AGI S ++ + T +T +S SAIAT
Sbjct: 96 RMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIAT 155
Query: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMI 403
NG V GG+YY+ISRSLGPEFGGA+GL F A AMY++G E ++ L +
Sbjct: 156 NGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFK 215
Query: 404 DE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
E +N++R+ G + + + G+++ K +V L ++L+I
Sbjct: 216 AEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSI 267
Score = 53.9 bits (128), Expect = 9e-07
Identities = 31/110 (28%), Positives = 65/110 (59%), Gaps = 10/110 (9%)
Query: 1021 KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSK 1078
+ +IDVWW+ DGG+ +L+P+LL K W+ CK+R+F ++ N I ++ + T L
Sbjct: 823 EGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQM-KKDLTTFLYH 881
Query: 1079 FRIDFSDIMVL----GDINTKPKKENIIAFE--EIIEPYRLHEDDKEQDI 1122
RI +++ V+ DI+ ++ ++ + +I++ L ++++E++I
Sbjct: 882 LRIT-AEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREI 930
Score = 46.6 bits (109), Expect = 1e-04
Identities = 21/68 (30%), Positives = 41/68 (60%)
Query: 1145 KTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNH 1204
+ + +RLNE++ + S A ++++++P + YM +LE L++ L ++LVRG
Sbjct: 1049 RMHTAVRLNEVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGG 1108
Query: 1205 QSVLTFYS 1212
+ V+T YS
Sbjct: 1109 REVITIYS 1116
>gi|123701900 solute carrier family 12 (potassium/chloride
transporters), member 7 [Homo sapiens]
Length = 1083
Score = 221 bits (562), Expect = 4e-57
Identities = 144/422 (34%), Positives = 214/422 (50%), Gaps = 48/422 (11%)
Query: 486 TFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSC-- 543
+F + I+FP+ TGI+AG+N SGDL D Q +IP GT+LAI+ T+ +Y+ V G+C
Sbjct: 419 SFTLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIE 478
Query: 544 --VVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTP 601
V+RD G L N V+ M++ +P
Sbjct: 479 GVVLRDKFGEA---------------------------------LQGNL-VIGMLAWPSP 504
Query: 602 -LISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGK-NNEPLRGYILTF 659
+I G F +T + L SL AP++ QA+ +D I P Q+F G+GK N EP +LT
Sbjct: 505 WVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQVF--GHGKANGEPTWALLLTV 562
Query: 660 LIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719
LI ILIA L+ +API+S FFL Y +N + +L ++P WRP FK+Y+ +S LG
Sbjct: 563 LICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKFYHWTLSFLG 622
Query: 720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHS-IRLS 778
LC +MF+ +W+ AL +I +Y Y+ Y+ + WG + L+ LNA +++ +R+
Sbjct: 623 MSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKEWGDGIRGLS-LNAARYALLRVE 681
Query: 779 GVEDHVKNFRPQCLVMTGAPNSR----PALLHLVHDFTKNVGLMICGHVHMGPRRQAMKE 834
H KN+RPQ LVM + P LL GL I G V G E
Sbjct: 682 HGPPHTKNWRPQVLVMLNLDAEQAVKHPRLLSFTSQLKAGKGLTIVGSVLEGTYLDKHME 741
Query: 835 MSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQ 894
+ + + K K F V + LR+G +L+Q+AGLG +K NT+++ + W Q
Sbjct: 742 AQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQSAGLGGLKHNTVLMAWPASWKQ 801
Query: 895 AD 896
D
Sbjct: 802 ED 803
Score = 131 bits (330), Expect = 3e-30
Identities = 82/232 (35%), Positives = 126/232 (54%), Gaps = 34/232 (14%)
Query: 249 ELEKEPFEDG-----FANGEESTPTRDAVVT----YTAESKGVV---------------- 283
E+E+E F +G F +S P +++ YT S+GVV
Sbjct: 57 EVEQESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAP 116
Query: 284 KFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIAT 343
+ G GV + C+ NI GV+LF+RL+WIVG AG+ S L++ M T +T +S SAIAT
Sbjct: 117 RMGTFIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIAT 176
Query: 344 NGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMI 403
NG V GG+YY+ISRSLGPEFGGA+GL F A AMY++G E + + + +
Sbjct: 177 NGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQ 236
Query: 404 DE---------INDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAI 446
E ++++R+ G T+V++ + G+++ K +V L ++L+I
Sbjct: 237 AEAAGGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSI 288
Score = 74.3 bits (181), Expect = 6e-13
Identities = 60/257 (23%), Positives = 120/257 (46%), Gaps = 53/257 (20%)
Query: 1007 KLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKI--NR 1064
K +++ Q Q++ G IDVWW+ DGG+ +L+P+LL K W+ C++R+F ++ N
Sbjct: 829 KNVDSFPQNQERFGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNS 888
Query: 1065 IDHDRRAMATLLSKFRIDFSDI----MVLGDINTKPKKENIIAFE--EIIEPYRLHEDDK 1118
I ++ + L RI +++ MV DI+ + ++ + ++++ +L ++++
Sbjct: 889 IQM-KKDLQMFLYHLRIS-AEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQ 946
Query: 1119 EQD-----------------------IADKMKED--------EPWRITDNELELYK---- 1143
E++ DK++ E +R D L +K
Sbjct: 947 EREAQLIHDRNTASHTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFS 1006
Query: 1144 --------TKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLP 1195
+ + ++LN ++ S A ++++++P K YM +LE L++ L
Sbjct: 1007 MKPDQSNVRRMHTAVKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLN 1066
Query: 1196 PILLVRGNHQSVLTFYS 1212
+LLVRG + V+T YS
Sbjct: 1067 RVLLVRGGGREVITIYS 1083
>gi|110832843 TBP-associated factor 4 [Homo sapiens]
Length = 1085
Score = 50.4 bits (119), Expect = 1e-05
Identities = 50/168 (29%), Positives = 64/168 (38%), Gaps = 18/168 (10%)
Query: 3 PRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDE-GP 61
P+P AP + V +TP AA P A PS P APA+ P
Sbjct: 229 PKPAAPGT-------VIQTPPFVGAAAP----PAPAAPSPPAAPAPAAPAAAPPPPPPAP 277
Query: 62 AAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGE 121
A G P GP + ++N G A AA A A AAG AG P G
Sbjct: 278 ATLARPPGHPAGPPTAAPAVPPPAAAQNGGSA----GAAPAPAPAAGGPAGVSGQPGPGA 333
Query: 122 ASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNV 169
A+ + PA G + + V PAA + A + A V GP +
Sbjct: 334 AA--AAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTM 379
Score = 41.2 bits (95), Expect = 0.006
Identities = 36/125 (28%), Positives = 44/125 (35%), Gaps = 9/125 (7%)
Query: 5 PTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAA 64
P AP+ GAPG A A + PG P P A + +R +A
Sbjct: 75 PAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSA 134
Query: 65 GDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASG 124
G P P+ + AG A A AA AA A G G G P G G
Sbjct: 135 GS-----CAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPG----PGPGPGPG 185
Query: 125 ESEPA 129
+PA
Sbjct: 186 PGKPA 190
Score = 39.7 bits (91), Expect = 0.018
Identities = 60/216 (27%), Positives = 77/216 (35%), Gaps = 30/216 (13%)
Query: 4 RPTAPSSGAP----------GLAG-VGETPSAAALAAARVELP-GTAVPSVPEDAAPASR 51
RP P+ AP G AG P+AAA+AA P G A P+ P AA A+R
Sbjct: 112 RPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGP--AALAAR 169
Query: 52 DGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAA---- 107
G G G G G+P GP +Q+ N+ AAA A + AA
Sbjct: 170 AGPGPGPGPGPGPGPGPGKPAGPGAAQT-LNGSAALLNSHHAAAPAVSLVNNGPAALLPL 228
Query: 108 ---GAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGV 164
A QTP A+ PA S A P A +L+ G
Sbjct: 229 PKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPA 288
Query: 165 DGPN--------VSFQNGGDTVLSEGSSLHSGGGGG 192
P + QNGG + + +GG G
Sbjct: 289 GPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAG 324
>gi|153070260 myristoylated alanine-rich protein kinase C substrate
[Homo sapiens]
Length = 332
Score = 49.3 bits (116), Expect = 2e-05
Identities = 47/153 (30%), Positives = 56/153 (36%), Gaps = 34/153 (22%)
Query: 13 PGLAGVGETPSAA-ALAAARVELPGTAVPSVPEDAAPASRDGGG----VRDEGPAAAGDG 67
PG A V +PS A V++ G A P+ E A G E PAAAG G
Sbjct: 19 PGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAKEELQANGSAPAADKEEPAAAGSG 78
Query: 68 LGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESE 127
P AA AAAAA AGA K+ PA+GEA+
Sbjct: 79 AASP--------------------SAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGS 118
Query: 128 PAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAA 160
P EA AASS++ D A
Sbjct: 119 PTAAEGEAAS---------AASSTSSPKAEDGA 142
Score = 45.8 bits (107), Expect = 2e-04
Identities = 50/187 (26%), Positives = 63/187 (33%), Gaps = 27/187 (14%)
Query: 5 PTAPSSGA--PGLAGVGETPSAAA--LAAARVELPGTAVPSVPEDAAPASRDGGGVR--- 57
P A SGA P A GE +AAA A+ VE A E +P + +G
Sbjct: 72 PAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGEAASAAS 131
Query: 58 -DEGPAAAGDGLGRPLGPTPSQSR-------------FQVDLVSENAGRAAAAAAAAAAA 103
P A P TP + + F + AG A A AA
Sbjct: 132 STSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEG 191
Query: 104 AAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVG 163
AG A G ASGE A G E A G + AA +++ A V
Sbjct: 192 GKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGE------EGAAGGDPQEAKPQEAAVA 245
Query: 164 VDGPNVS 170
+ P S
Sbjct: 246 PEKPPAS 252
Score = 42.4 bits (98), Expect = 0.003
Identities = 37/127 (29%), Positives = 53/127 (41%), Gaps = 7/127 (5%)
Query: 17 GVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDG---GGVRDEGPAAAGDGLGRPLG 73
G E AA AAA + P + A A +G G ++ P A +P
Sbjct: 192 GKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPA 251
Query: 74 PTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGE----ASGESEPA 129
+++ + V E A A+AAA A +AAG GA +Q A E A+ S A
Sbjct: 252 SDETKAAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAPPEQEAAPAEEPAAAAASSACA 311
Query: 130 KGSEEAK 136
S+EA+
Sbjct: 312 APSQEAQ 318
Score = 31.6 bits (70), Expect = 4.8
Identities = 23/84 (27%), Positives = 33/84 (39%), Gaps = 4/84 (4%)
Query: 87 SENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDP 146
S+ A + AAA AA A+ Q + +G++ PA AK + N P
Sbjct: 6 SKTAAKGEAAAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAKEELQANGSAP 65
Query: 147 AASSSAEDSLSDAAGVGVDGPNVS 170
AA AAG G P+ +
Sbjct: 66 AADKEE----PAAAGSGAASPSAA 85
Score = 31.6 bits (70), Expect = 4.8
Identities = 37/131 (28%), Positives = 44/131 (33%), Gaps = 26/131 (19%)
Query: 7 APSSGAPGLAGVGETPSAAALAA----ARVELPGTAVPSVPEDAAPASRDGGGVRDEGPA 62
A GA G P AA+A A E PS E+ E P+
Sbjct: 224 AGEEGAAGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASAAACEAPS 283
Query: 63 AAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEA 122
AAG G P Q AA A AAAAA + A A E
Sbjct: 284 AAGP------GAPPEQE----------------AAPAEEPAAAAASSACAAPSQEAQPEC 321
Query: 123 SGESEPAKGSE 133
S E+ PA+ +E
Sbjct: 322 SPEAPPAEAAE 332
>gi|210147522 zinc finger, SWIM-type containing 6 [Homo sapiens]
Length = 1215
Score = 48.1 bits (113), Expect = 5e-05
Identities = 35/80 (43%), Positives = 38/80 (47%), Gaps = 14/80 (17%)
Query: 48 PASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAA 107
P GGG G A G G G P + + A +AAAAAAAAAAAAAA
Sbjct: 137 PGDDSGGG----GGAGGGGGGGSSSSPAATSA----------AATSAAAAAAAAAAAAAA 182
Query: 108 GAGAGAKQTPADGEASGESE 127
AGAGA A G A G E
Sbjct: 183 AAGAGAPSVGAAGAADGGDE 202
Score = 30.8 bits (68), Expect = 8.2
Identities = 20/63 (31%), Positives = 25/63 (39%)
Query: 5 PTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAA 64
P S G G G G S+++ AA A + AA A+ G G G A A
Sbjct: 137 PGDDSGGGGGAGGGGGGGSSSSPAATSAAATSAAAAAAAAAAAAAAAAGAGAPSVGAAGA 196
Query: 65 GDG 67
DG
Sbjct: 197 ADG 199
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 48.1 bits (113), Expect = 5e-05
Identities = 54/255 (21%), Positives = 109/255 (42%), Gaps = 43/255 (16%)
Query: 298 NIWGVMLFIRLSWIVGQAG-IGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLI 356
NI G +F+ ++ AG +GL+++V ++ +T + L + + + GG Y +
Sbjct: 52 NIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVT-IPKSGGDYSYV 110
Query: 357 SRSLGPEFGGAIGLIFAFANAVAV-----AMYVVGFAETVVELLKEHSILMIDEINDIRI 411
FGG G + + + + A+ + F+ V++ L + +R+
Sbjct: 111 KDI----FGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFP---TCFPPESGLRL 163
Query: 412 IGAITVVILLGISVAGMEWEAKAQ--------IVLLVILLLAIGDFVIGTFIPLESKKPK 463
+ AI +++L ++ + + W + Q + L +I+++ I G + LE PK
Sbjct: 164 LAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLE---PK 220
Query: 464 GFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGAN----ISGDLADPQSAIP 519
F ENF +E + A+ F + G N ++ +L DP +P
Sbjct: 221 NAF--------ENF------QEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLP 266
Query: 520 KGTLLAILITTLVYV 534
+ ++I + T VYV
Sbjct: 267 RAIFISIPLVTFVYV 281
>gi|24497554 homeobox A13 [Homo sapiens]
Length = 388
Score = 47.0 bits (110), Expect = 1e-04
Identities = 41/127 (32%), Positives = 53/127 (41%), Gaps = 11/127 (8%)
Query: 20 ETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGDGLGR--------- 70
E +AAA AAA G P AA A+ V AAA +
Sbjct: 36 EGAAAAAAAAAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPA 95
Query: 71 PLGP--TPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEP 128
PL P + S + A AAAAAAAAAAAAAA+ +G PA EA+ + P
Sbjct: 96 PLAPGAASAYSSAPGEAPPSAAAAAAAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSP 155
Query: 129 AKGSEEA 135
+ ++
Sbjct: 156 CSAAAQS 162
Score = 42.7 bits (99), Expect = 0.002
Identities = 36/106 (33%), Positives = 46/106 (43%), Gaps = 5/106 (4%)
Query: 94 AAAAAAAAAAAAAAGAGAGAKQTPADGEASGE----SEPAKGSEEAKGRFRVNFVDPA-A 148
AAAAAAAAAAAAAAGAG G PA A G + A + A + R PA
Sbjct: 38 AAAAAAAAAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPAPL 97
Query: 149 SSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSG 194
+ A + S A G + + ++ SGG G +G
Sbjct: 98 APGAASAYSSAPGEAPPSAAAAAAAAAAAAAAAAAASSSGGPGPAG 143
Score = 36.6 bits (83), Expect = 0.15
Identities = 47/185 (25%), Positives = 62/185 (33%), Gaps = 6/185 (3%)
Query: 59 EGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPA 118
EG AAA F + G + AAAAAAAAAAAA PA
Sbjct: 36 EGAAAAAAAAAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPA 95
Query: 119 DGEASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTV 178
S + EA AA+++A + S + G G GP + +
Sbjct: 96 PLAPGAASAYSSAPGEAPPSAAAAAAAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSP 155
Query: 179 LSEGSSLHSG------GGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAA 232
S + SG G GSG++ H N + A D Y TA
Sbjct: 156 CSAAAQSSSGPAALPYGYFGSGYYPCARMGPHPNAIKSCAQPASAAAAAAFADKYMDTAG 215
Query: 233 QLGEK 237
E+
Sbjct: 216 PAAEE 220
Score = 35.4 bits (80), Expect = 0.33
Identities = 44/157 (28%), Positives = 63/157 (40%), Gaps = 32/157 (20%)
Query: 3 PRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPA 62
P P AP + + + GE P +AA AAA A + AA AS GG GPA
Sbjct: 94 PAPLAPGAASAYSSAPGEAPPSAAAAAA-------AAAAAAAAAAAASSSGG----PGPA 142
Query: 63 AAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAG----AKQTPA 118
GP +++ Q S AAA +++ AA G+G A+ P
Sbjct: 143 ----------GPAGAEAAKQCSPCS-----AAAQSSSGPAALPYGYFGSGYYPCARMGPH 187
Query: 119 DGEASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDS 155
++PA S A F ++D A ++ E S
Sbjct: 188 PNAIKSCAQPA--SAAAAAAFADKYMDTAGPAAEEFS 222
Score = 34.3 bits (77), Expect = 0.74
Identities = 34/126 (26%), Positives = 48/126 (38%), Gaps = 6/126 (4%)
Query: 7 APSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGD 66
A ++ A G G G AAA A + A + AA A++ + P A G
Sbjct: 45 AAAAAAAGAGGGGFPHPAAAAAGGNFSVAAAAAAAA---AAAANQCRNLMAHPAPLAPGA 101
Query: 67 GLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAA---AAAAGAGAGAKQTPADGEAS 123
P + + A AAAAAA+++ A AGA A + +P A
Sbjct: 102 ASAYSSAPGEAPPSAAAAAAAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSAAAQ 161
Query: 124 GESEPA 129
S PA
Sbjct: 162 SSSGPA 167
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 47.0 bits (110), Expect = 1e-04
Identities = 38/181 (20%), Positives = 77/181 (42%), Gaps = 8/181 (4%)
Query: 13 PGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPL 72
PG G E S +L + P A S P+ P + DG ++ GP + G P
Sbjct: 2487 PGAGGWQEPKSLLSLGS----YPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPK 2542
Query: 73 GPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGS 132
P +Q+ SE++ +++ +++++++++++G+ ++ +G+ +G+ G
Sbjct: 2543 SPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEE---EGDKNGDGGCGTGG 2599
Query: 133 EEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGG 192
PA+SSS+ S S ++ + S + + S SS S
Sbjct: 2600 RNCSAA-SSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2658
Query: 193 S 193
S
Sbjct: 2659 S 2659
>gi|126090909 engrailed homeobox 1 [Homo sapiens]
Length = 392
Score = 46.6 bits (109), Expect = 1e-04
Identities = 39/111 (35%), Positives = 44/111 (39%), Gaps = 20/111 (18%)
Query: 46 AAPASRDGGG--VRDEGPAAAGDGLGRPLG------------------PTPSQSRFQVDL 85
AA GGG RD G AAG PLG P
Sbjct: 131 AARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAAAGA 190
Query: 86 VSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAK 136
+ AG AAAAAAAAAA AAA A A AK + G SG + G++ K
Sbjct: 191 GASKAGNPAAAAAAAAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGTK 241
Score = 34.3 bits (77), Expect = 0.74
Identities = 35/126 (27%), Positives = 42/126 (33%), Gaps = 9/126 (7%)
Query: 7 APSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGD 66
A GA G V A V GT P + G PAAAG
Sbjct: 131 AARGGAGGGGRVERDRGQTAAGRDPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAAAGA 190
Query: 67 GLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGES 126
G + P + + A A AAAAAAAAA + G G+ A G
Sbjct: 191 GASKAGNPAAAAAA---------AAAAVAAAAAAAAAKPSDTGGGGSGGGAGSPGAQGTK 241
Query: 127 EPAKGS 132
P G+
Sbjct: 242 YPEHGN 247
>gi|39812496 Sp8 transcription factor isoform 1 [Homo sapiens]
Length = 508
Score = 45.1 bits (105), Expect = 4e-04
Identities = 60/208 (28%), Positives = 86/208 (41%), Gaps = 27/208 (12%)
Query: 18 VGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPS 77
+G TP A+ AA G+ PS + +S G G +++ + + S
Sbjct: 12 LGSTP--LAMLAATCNKIGSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSASCNVVGS-S 68
Query: 78 QSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKG 137
S F V S N G ++AAAAAAAAAAAAA A + + G + G S + S A
Sbjct: 69 LSSFGVSGASRNGGSSSAAAAAAAAAAAAA---ALVSDSFSCGGSPGSSAFSLTSSSAAA 125
Query: 138 RFRVNFVDPAASSSAEDSLSDAAGVGV-DGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHH 196
AA+++A S A V P VS +GG GGGGG G
Sbjct: 126 A-------AAAAAAAASSSPFANDYSVFQAPGVSGGSGG-----------GGGGGGGGSS 167
Query: 197 QHYYYDTHTNTYYLRTFGHNTMDAVPRI 224
H +H + + H ++D + I
Sbjct: 168 AHSQDGSHQPVFISKV--HTSVDGLQGI 193
>gi|39812501 Sp8 transcription factor isoform 2 [Homo sapiens]
Length = 490
Score = 44.7 bits (104), Expect = 5e-04
Identities = 48/149 (32%), Positives = 64/149 (42%), Gaps = 24/149 (16%)
Query: 77 SQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAK 136
S S F V S N G ++AAAAAAAAAAAAA A + + G + G S + S A
Sbjct: 50 SLSSFGVSGASRNGGSSSAAAAAAAAAAAAA---ALVSDSFSCGGSPGSSAFSLTSSSAA 106
Query: 137 GRFRVNFVDPAASSSAEDSLSDAAGVGV-DGPNVSFQNGGDTVLSEGSSLHSGGGGGSGH 195
AA+++A S A V P VS +GG GGGGG G
Sbjct: 107 AA-------AAAAAAAASSSPFANDYSVFQAPGVSGGSGG-----------GGGGGGGGS 148
Query: 196 HQHYYYDTHTNTYYLRTFGHNTMDAVPRI 224
H +H + + H ++D + I
Sbjct: 149 SAHSQDGSHQPVFISKV--HTSVDGLQGI 175
Score = 32.0 bits (71), Expect = 3.7
Identities = 61/270 (22%), Positives = 96/270 (35%), Gaps = 55/270 (20%)
Query: 3 PRPTAPSSGAPGLA-GVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGP 61
P P++ S + G +++ ++A + G+++ S + ASR+GG
Sbjct: 14 PSPSSLSDSSSSFGKGFHPWKRSSSSSSASCNVVGSSLSSF--GVSGASRNGGSSSAAAA 71
Query: 62 AAAGDGLGRPL-------GPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAA-------AA 107
AAA L G +P S F + S A AAAAAAA+++ A A
Sbjct: 72 AAAAAAAAAALVSDSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAP 131
Query: 108 GAGAGAKQTPADGEASGESEPAKGSEE-------------AKGRF-RVNFVDPAAS--SS 151
G G+ G + GS + +G + RV P S
Sbjct: 132 GVSGGSGGGGGGGGGGSSAHSQDGSHQPVFISKVHTSVDGLQGIYPRVGMAHPYESWFKP 191
Query: 152 AEDSLSDAAGVGVDGPN---------VSFQNGGDTVLSEGS----------SLHSGGGGG 192
+ L A VG G + + QN GS SLHS GG
Sbjct: 192 SHPGLGAAGEVGSAGASSWWDVGAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSPLGGY 251
Query: 193 SGHH---QHYYYDTHTNTYYLRTFGHNTMD 219
+ + H + + +++ L G + MD
Sbjct: 252 NSDYSGLSHSAFSSGASSHLLSPAGQHLMD 281
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,971,036
Number of Sequences: 37866
Number of extensions: 2117903
Number of successful extensions: 17064
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 156
Number of HSP's successfully gapped in prelim test: 369
Number of HSP's that attempted gapping in prelim test: 12472
Number of HSP's gapped (non-prelim): 2515
length of query: 1212
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1098
effective length of database: 13,930,794
effective search space: 15296011812
effective search space used: 15296011812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.