Search of human proteins with 4506431

Search of human proteins with 4506431

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
         (1047 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]      2108   0.0  
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]     1753   0.0  
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho...   180   7e-45
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho...   180   7e-45
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]    178   3e-44
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]      178   3e-44
gi|130502162 RAS protein activator like 3 [Homo sapiens]              163   7e-40
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi...   150   8e-36
gi|4759026 RAS protein activator like 1 [Homo sapiens]                137   5e-32
gi|38201692 RAS p21 protein activator 3 [Homo sapiens]                133   8e-31
gi|12545408 RAS p21 protein activator 2 [Homo sapiens]                122   2e-27
gi|4557793 neurofibromin isoform 2 [Homo sapiens]                     112   1e-24
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]     108   3e-23
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]     108   3e-23
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva...   105   2e-22
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva...   105   2e-22
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva...   105   2e-22
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva...   105   2e-22
gi|109826564 neurofibromin isoform 1 [Homo sapiens]                   105   3e-22
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit...    84   5e-16
gi|5729856 GRB2-related adaptor protein [Homo sapiens]                 74   5e-13
gi|117320537 phospholipase C, gamma 2 [Homo sapiens]                   70   1e-11
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    68   4e-11
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]           66   2e-10
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]            66   2e-10
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [...    64   7e-10
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]      64   7e-10
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]               63   2e-09
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...    63   2e-09
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...    63   2e-09

>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
          Length = 1047

 Score = 2108 bits (5463), Expect = 0.0
 Identities = 1047/1047 (100%), Positives = 1047/1047 (100%)

Query: 1    MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT 60
            MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT
Sbjct: 1    MMAAEAGSEEGGPVTAGAGGGGAAAGSSAYPAVCRVKIPAALPVAAAPYPGLVETGVAGT 60

Query: 61   LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP 120
            LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP
Sbjct: 61   LGGGAALGSEFLGAGSVAGALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLP 120

Query: 121  TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ 180
            TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ
Sbjct: 121  TSLLAETLGPGGGFPPLPPPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQ 180

Query: 181  WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240
            WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
Sbjct: 181  WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240

Query: 241  IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS 300
            IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
Sbjct: 241  IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS 300

Query: 301  FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE 360
            FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
Sbjct: 301  FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE 360

Query: 361  AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG 420
            AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
Sbjct: 361  AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG 420

Query: 421  DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY 480
            DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
Sbjct: 421  DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY 480

Query: 481  LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC 540
            LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
Sbjct: 481  LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC 540

Query: 541  FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI 600
            FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
Sbjct: 541  FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI 600

Query: 601  EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN 660
            EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN
Sbjct: 601  EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN 660

Query: 661  KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE 720
            KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE
Sbjct: 661  KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE 720

Query: 721  EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM 780
            EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM
Sbjct: 721  EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM 780

Query: 781  EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED 840
            EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED
Sbjct: 781  EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED 840

Query: 841  VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV 900
            VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV
Sbjct: 841  VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV 900

Query: 901  FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI 960
            FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI
Sbjct: 901  FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI 960

Query: 961  KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ 1020
            KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ
Sbjct: 961  KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ 1020

Query: 1021 HVLKKLLAITELLQQKQNQYTKTNDVR 1047
            HVLKKLLAITELLQQKQNQYTKTNDVR
Sbjct: 1021 HVLKKLLAITELLQQKQNQYTKTNDVR 1047


>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
          Length = 870

 Score = 1753 bits (4539), Expect = 0.0
 Identities = 867/867 (100%), Positives = 867/867 (100%)

Query: 181  WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240
            WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY
Sbjct: 4    WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 63

Query: 241  IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS 300
            IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS
Sbjct: 64   IGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEIS 123

Query: 301  FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE 360
            FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE
Sbjct: 124  FLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQE 183

Query: 361  AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG 420
            AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG
Sbjct: 184  AYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIG 243

Query: 421  DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY 480
            DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY
Sbjct: 244  DIIDHYRKEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKGY 303

Query: 481  LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC 540
            LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC
Sbjct: 304  LLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSVYVVHDSLFGRPNC 363

Query: 541  FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI 600
            FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI
Sbjct: 364  FQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKRLRQVSSLVLHI 423

Query: 601  EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN 660
            EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN
Sbjct: 424  EEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEITLSN 483

Query: 661  KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE 720
            KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE
Sbjct: 484  KTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPE 543

Query: 721  EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM 780
            EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM
Sbjct: 544  EEYSEFKELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISM 603

Query: 781  EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED 840
            EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED
Sbjct: 604  EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNED 663

Query: 841  VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV 900
            VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV
Sbjct: 664  VNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFV 723

Query: 901  FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI 960
            FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI
Sbjct: 724  FLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFI 783

Query: 961  KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ 1020
            KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ
Sbjct: 784  KSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQ 843

Query: 1021 HVLKKLLAITELLQQKQNQYTKTNDVR 1047
            HVLKKLLAITELLQQKQNQYTKTNDVR
Sbjct: 844  HVLKKLLAITELLQQKQNQYTKTNDVR 870



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 33/107 (30%), Positives = 59/107 (55%), Gaps = 7/107 (6%)

Query: 349 KIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNEN-IQRFKICPTPNN 407
           K W+HGK+ +  A   L   G+  S+L+R SD  PG + L F +  N +  F+I     +
Sbjct: 2   KGWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGD 61

Query: 408 QFMMGGRYYNSIGDIIDHYRKEQ-IVEG----YYLKEPVPMQDQEQV 449
            + +GGR ++S+ D+I +Y     +++G    Y +  P P++D+ +V
Sbjct: 62  -YYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRV 107


>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
            sapiens]
          Length = 1065

 Score =  180 bits (456), Expect = 7e-45
 Identities = 146/527 (27%), Positives = 249/527 (47%), Gaps = 29/527 (5%)

Query: 530  VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 589
            VH S+ G+  CF++     S+      F+  +  + + WM+ L+     R   P   N R
Sbjct: 36   VHSSILGQDYCFEVTTSSGSK-----CFSCRSAAERDKWMENLR-----RAVHPNKDNSR 85

Query: 590  LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLP 648
             R    L L + EA  LP K      C + L+ V  A+T  + +  N  W E F F +LP
Sbjct: 86   -RVEHILKLWVIEAKDLPAKK--KYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLP 142

Query: 649  P----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 704
            P     ++ +  T   K KK ++  +  +    + +      ++W+ + +  P  G  PG
Sbjct: 143  PLRTVTVHLYRET-DKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPG 201

Query: 705  SL-RVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILLRIFLH 762
             + R++ARY    I+P E Y EF E I    L +  AL  +   + +  +AS L+ I   
Sbjct: 202  PMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQS 261

Query: 763  E-KLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKI 821
              K++  L   +        D    +FR  TLA+  +E+Y+K    +++  AL + I  +
Sbjct: 262  TGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKAL 321

Query: 822  MESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSV 881
             ES ++CE+ PSK     D+  +  +L         KI  +  + P  L+ ++   ++  
Sbjct: 322  YESDENCEVDPSKCSA-ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQEC 380

Query: 882  QHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLA 941
              +   + +   R++S  +FLR +CPAI++P +FN++ + P    ARTL L+AK  QNLA
Sbjct: 381  SSRGRPDIS--ERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLA 438

Query: 942  NLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTE-HSRTDLSRDLAALHE 1000
            N  +FG+KE YM  +N F++     M  FL E+ N   L +T       DL R+L++LH 
Sbjct: 439  NFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHS 498

Query: 1001 ICVAHSDEL-RTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDV 1046
            +      +L +++ ++ G    +L+ +   T L      Q   TND+
Sbjct: 499  LLWEAVSQLEQSIVSKLGPLPRILRDV--HTALSTPGSGQLPGTNDL 543


>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
            sapiens]
          Length = 1132

 Score =  180 bits (456), Expect = 7e-45
 Identities = 146/527 (27%), Positives = 249/527 (47%), Gaps = 29/527 (5%)

Query: 530  VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 589
            VH S+ G+  CF++     S+      F+  +  + + WM+ L+     R   P   N R
Sbjct: 132  VHSSILGQDYCFEVTTSSGSK-----CFSCRSAAERDKWMENLR-----RAVHPNKDNSR 181

Query: 590  LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFVFDDLP 648
             R    L L + EA  LP K      C + L+ V  A+T  + +  N  W E F F +LP
Sbjct: 182  -RVEHILKLWVIEAKDLPAKK--KYLCELCLDDVLYARTTGKLKTDNVFWGEHFEFHNLP 238

Query: 649  P----DINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 704
            P     ++ +  T   K KK ++  +  +    + +      ++W+ + +  P  G  PG
Sbjct: 239  PLRTVTVHLYRET-DKKKKKERNSYLGLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPG 297

Query: 705  SL-RVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILLRIFLH 762
             + R++ARY    I+P E Y EF E I    L +  AL  +   + +  +AS L+ I   
Sbjct: 298  PMIRIKARYQTITILPMEMYKEFAEHITNHYLGLCAALEPILSAKTKEEMASALVHILQS 357

Query: 763  E-KLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKI 821
              K++  L   +        D    +FR  TLA+  +E+Y+K    +++  AL + I  +
Sbjct: 358  TGKVKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKAL 417

Query: 822  MESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSV 881
             ES ++CE+ PSK     D+  +  +L         KI  +  + P  L+ ++   ++  
Sbjct: 418  YESDENCEVDPSKCSA-ADLPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQEC 476

Query: 882  QHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLA 941
              +   + +   R++S  +FLR +CPAI++P +FN++ + P    ARTL L+AK  QNLA
Sbjct: 477  SSRGRPDIS--ERLISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLA 534

Query: 942  NLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTE-HSRTDLSRDLAALHE 1000
            N  +FG+KE YM  +N F++     M  FL E+ N   L +T       DL R+L++LH 
Sbjct: 535  NFAKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHS 594

Query: 1001 ICVAHSDEL-RTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDV 1046
            +      +L +++ ++ G    +L+ +   T L      Q   TND+
Sbjct: 595  LLWEAVSQLEQSIVSKLGPLPRILRDV--HTALSTPGSGQLPGTNDL 639


>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
          Length = 1280

 Score =  178 bits (451), Expect = 3e-44
 Identities = 141/491 (28%), Positives = 240/491 (48%), Gaps = 38/491 (7%)

Query: 526  SVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGT 585
            SV  +H S+ G+  CF++     S+      F+  +  + + WM+ L+     R   P  
Sbjct: 260  SVKPLHSSILGQDFCFEVTYLSGSK-----CFSCNSASERDKWMENLR-----RTVQPNK 309

Query: 586  SNKRLRQVSSLVLHIEEAHKL-PVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFV 643
             N R R  + L L I EA  L P K +   +C + L+    A+T ++ +  N  W E F 
Sbjct: 310  DNCR-RAENVLRLWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFWGEHFE 365

Query: 644  FDDLPPDINRFEITL----SNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLK 699
            F  LPP ++   + +      K KK K+  +  +    + +      ++W+ +S+  P K
Sbjct: 366  FFSLPP-LHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 424

Query: 700  GIEPG-SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILL 757
            G   G S+R+++R+    I+P E+Y EF E +      +   L  V   +++  LA  L+
Sbjct: 425  GKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALV 484

Query: 758  RIFLHEKLESLLLCTLNDREISMEDEATTL-FRATTLASTLMEQYMKATATQFVHHALKD 816
             I          L  L   E+    E   L FR  T+A+  +E+Y+K    Q++H AL +
Sbjct: 485  HILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGE 544

Query: 817  SILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE-KIFMASEILPPTLRYIYG 875
             I  + ES ++CE+ PSK   +E ++      L +  EL   KI  +  + P  L+ ++ 
Sbjct: 545  FIKALYESDENCEVDPSKCSSSELIDHQSN--LKMCCELAFCKIINSYCVFPRELKEVFA 602

Query: 876  CLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAK 935
              ++   ++   + +   R++S  +FLR +CPAI++P +FN++ + P    +RTL L+AK
Sbjct: 603  SWKQQCLNRGKQDIS--ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 660

Query: 936  SVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHS-----RTD 990
             +QNLAN  +FG KE YM  +N F++     M  FL E+ N    PDT  ++       D
Sbjct: 661  VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN----PDTISNTPGFDGYID 716

Query: 991  LSRDLAALHEI 1001
            L R+L+ LH +
Sbjct: 717  LGRELSVLHSL 727


>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
          Length = 1139

 Score =  178 bits (451), Expect = 3e-44
 Identities = 141/491 (28%), Positives = 240/491 (48%), Gaps = 38/491 (7%)

Query: 526  SVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGT 585
            SV  +H S+ G+  CF++     S+      F+  +  + + WM+ L+     R   P  
Sbjct: 112  SVKPLHSSILGQDFCFEVTYLSGSK-----CFSCNSASERDKWMENLR-----RTVQPNK 161

Query: 586  SNKRLRQVSSLVLHIEEAHKL-PVKHFTNPYCNIYLNSVQVAKTHAR-EGQNPVWSEEFV 643
             N R R  + L L I EA  L P K +   +C + L+    A+T ++ +  N  W E F 
Sbjct: 162  DNCR-RAENVLRLWIIEAKDLAPKKKY---FCELCLDDTLFARTTSKTKADNIFWGEHFE 217

Query: 644  FDDLPPDINRFEITL----SNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLK 699
            F  LPP ++   + +      K KK K+  +  +    + +      ++W+ +S+  P K
Sbjct: 218  FFSLPP-LHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNK 276

Query: 700  GIEPG-SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVCG-QDRTLLASILL 757
            G   G S+R+++R+    I+P E+Y EF E +      +   L  V   +++  LA  L+
Sbjct: 277  GKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALV 336

Query: 758  RIFLHEKLESLLLCTLNDREISMEDEATTL-FRATTLASTLMEQYMKATATQFVHHALKD 816
             I          L  L   E+    E   L FR  T+A+  +E+Y+K    Q++H AL +
Sbjct: 337  HILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGE 396

Query: 817  SILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE-KIFMASEILPPTLRYIYG 875
             I  + ES ++CE+ PSK   +E ++      L +  EL   KI  +  + P  L+ ++ 
Sbjct: 397  FIKALYESDENCEVDPSKCSSSELIDHQSN--LKMCCELAFCKIINSYCVFPRELKEVFA 454

Query: 876  CLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAK 935
              ++   ++   + +   R++S  +FLR +CPAI++P +FN++ + P    +RTL L+AK
Sbjct: 455  SWKQQCLNRGKQDIS--ERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK 512

Query: 936  SVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHS-----RTD 990
             +QNLAN  +FG KE YM  +N F++     M  FL E+ N    PDT  ++       D
Sbjct: 513  VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN----PDTISNTPGFDGYID 568

Query: 991  LSRDLAALHEI 1001
            L R+L+ LH +
Sbjct: 569  LGRELSVLHSL 579


>gi|130502162 RAS protein activator like 3 [Homo sapiens]
          Length = 1011

 Score =  163 bits (413), Expect = 7e-40
 Identities = 134/491 (27%), Positives = 227/491 (46%), Gaps = 31/491 (6%)

Query: 527  VYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTS 586
            ++ +H SL G P+CFQ+     S       F+  +  + + W++      +LR+    T 
Sbjct: 248  IWPLHPSLLGEPHCFQVTWTGGSR-----CFSCRSAAERDRWIE------DLRRQFQPTQ 296

Query: 587  NKRLRQVSSLVLHIEEAHKLPVKHFTNP--YCNIYLNSVQVAKTHAREGQNPV-WSEEFV 643
            +   R+ + L + + EA  LP      P     ++L+   +A+T  R G   + W+E F 
Sbjct: 297  DNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFH 356

Query: 644  FDDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHAT--DEWFLLSSHIPLKGI 701
            F+ LPP   R  + L      S     + +  +     +  A   + WF      PL G 
Sbjct: 357  FEALPP-ARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWF------PLLGA 409

Query: 702  EPGS-LRVRARYSMEKIMPEEEYSEFKELILQKELHVVYALSHVC-GQDRTLLASILLRI 759
              G+ LR R R    +++P E Y E  E +      +  AL      Q +  LA+ ++R+
Sbjct: 410  PAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRV 469

Query: 760  FLHEKLESLLLCTLNDREISM-EDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSI 818
                     L+  L   E++        LFR  TLA+  +++YMK  A  ++   L   +
Sbjct: 470  LRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVV 529

Query: 819  LKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQ 878
             ++  S + CE+ PSK   +E +  +   L N   E+ E I  + +  P  L  ++   +
Sbjct: 530  RRLCASTEDCEVDPSKCPASE-LPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWR 588

Query: 879  KSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQ 938
            ++ + +   +  +  R+V   +FLRL+CPAIL P +F +  D P+P  ARTL L+AK +Q
Sbjct: 589  EACKERG--SEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQ 646

Query: 939  NLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNVP-ELPDTTEHSRTDLSRDLAA 997
            NLAN   FG KE YM  +N F++ +   M  FLD++  V  +   +      DL+  LA 
Sbjct: 647  NLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAV 706

Query: 998  LH-EICVAHSD 1007
            LH ++C   ++
Sbjct: 707  LHAQLCTIFAE 717


>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapiens]
          Length = 1343

 Score =  150 bits (378), Expect = 8e-36
 Identities = 129/506 (25%), Positives = 234/506 (46%), Gaps = 53/506 (10%)

Query: 530  VHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCNLRKSSPGTSNKR 589
            VH S+ G+  CF++     ++      FA  +  + + W++ LQ     R   P   N R
Sbjct: 209  VHSSILGQEFCFEVTTSSGTK-----CFACRSAAERDKWIENLQ-----RAVKPNKDNSR 258

Query: 590  LRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAR----EGQNPVWSEEFVFD 645
             R  + L L I EA +LP K     YC + L+ +  A+T ++     G    W E F F+
Sbjct: 259  -RVDNVLKLWIIEARELPPKK--RYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFN 315

Query: 646  DLPPDINRFEITL----SNKTKKSKDPDILFMRCQLSRLQKGHATDEWF---LLSSHIPL 698
            +LP  +    + L      K KK K   +  +   ++ L   H T++W+   L +     
Sbjct: 316  NLPA-VRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGS 374

Query: 699  KGIEPG------------------SLRVRARYSMEKIMPEEEYSEFKELILQKELHVVYA 740
             G+  G                  ++R++ARY    I+P E Y EF E +      +   
Sbjct: 375  GGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAV 434

Query: 741  LS---HVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTL 797
            L    +V G++    A + +     +  + L    +++ +  ME E   +FR  TLA+  
Sbjct: 435  LEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHL-IFRENTLATKA 493

Query: 798  MEQYMKATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVE 857
            +E+YM+    +++  A+ + I  + ES+++CE+ P K   +          L +  EL  
Sbjct: 494  IEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQAN--LRMCCELAL 551

Query: 858  -KIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFN 916
             K+  +  + P  L+ ++   +     +   +  +  R++S  +FLR +CPAI++P +F 
Sbjct: 552  CKVVNSHCVFPRELKEVFASWRLRCAERGRED--IADRLISASLFLRFLCPAIMSPSLFG 609

Query: 917  IISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGN 976
            ++ + P    +RTL L+AK +QNLAN  +F +KE ++  +N F++     M  FL E+ N
Sbjct: 610  LMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISN 669

Query: 977  VPELPDTTE-HSRTDLSRDLAALHEI 1001
            +  L +++      DL R+L+ LH +
Sbjct: 670  LDTLTNSSSFEGYIDLGRELSTLHAL 695


>gi|4759026 RAS protein activator like 1 [Homo sapiens]
          Length = 804

 Score =  137 bits (345), Expect = 5e-32
 Identities = 110/416 (26%), Positives = 195/416 (46%), Gaps = 41/416 (9%)

Query: 597 VLHIEEAHKLPVKHFTNPYCNIYLNSVQVAKTHAREGQNPVWSEEFVFDDLPPDINRFEI 656
           VLH  +     +   ++P+  ++  S  +  +  ++ + P W E     ++P   +   +
Sbjct: 139 VLHARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRV 198

Query: 657 TLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEP------GSLRVRA 710
            L +     K+  +  +      LQ+      WF L   +P    E       G+LRV+ 
Sbjct: 199 ELWDWDMVGKNDFLGMVEFSPKTLQQ-KPPKGWFRL---LPFPRAEEDSGGNLGALRVKV 254

Query: 711 RYSMEKIMPEEEYSEFKELILQK-----------ELHVVYALSHVCGQDRTLLASILLRI 759
           R   ++++P + Y    EL+++             L ++  L+   G  R  LA+ L+++
Sbjct: 255 RLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELT--LGDCRQDLATKLVKL 312

Query: 760 FLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSIL 819
           FL   L    L  L  RE++   +  TLFR+ +LAS  MEQ+MK     ++H  LK  I 
Sbjct: 313 FLGRGLAGHFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVIS 372

Query: 820 KIMESKQSCELSPSK--------------LEKNEDVNTNLTHLLNILSELVEKIFMASEI 865
           ++ E K+  EL P K              L + +   T+L  L   L  +V+ I  +   
Sbjct: 373 RVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGR 432

Query: 866 LPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS 923
            PP +R  +  L + V+ ++P   +  ++   +SGF+FLR   PAIL P++F++      
Sbjct: 433 CPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHAD 492

Query: 924 PIAARTLILVAKSVQNLANL-VEFG-AKEPYMEGVNPFIKSNKHRMIMFLDELGNV 977
           P  +R+L+L+AK+VQ++ NL  + G  KE +M  ++PF+     R+  FLD L +V
Sbjct: 493 PQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDV 548


>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
          Length = 834

 Score =  133 bits (335), Expect = 8e-31
 Identities = 103/405 (25%), Positives = 185/405 (45%), Gaps = 36/405 (8%)

Query: 596 LVLHIEEAHKLPVKHFT-NPYCNIYLNSV---QVAKTHA-REGQNPVWSEEFVFDDLPP- 649
           L   I E   LP+ +   +PY  + L      +  KT   R+  NP + E F F+   P 
Sbjct: 147 LATRIVECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEVTRPC 206

Query: 650 -------------DINRFEITL---SNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLL- 692
                        D+++ EI +   +    K  D  +  +R  L  L++  + + W+ L 
Sbjct: 207 SYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAWYFLQ 266

Query: 693 ---SSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQK------ELHVVYALSH 743
              +    LK  + GSLR+   Y+ + +   + YS  ++L+L+            + L  
Sbjct: 267 PRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGE 326

Query: 744 VCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMK 803
           VC +++   A  L+R+FLH       +  +   E+    +  T+FR  +LAS  +++ MK
Sbjct: 327 VC-REKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLASKCIDETMK 385

Query: 804 ATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS 863
                ++H  LK +I +I +S + CE+ P KL+  E++  N+ +L   +  +   I  + 
Sbjct: 386 LAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESG 445

Query: 864 EILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS 923
              P  +  I+  L+++   ++  +  +R   VS F+FLR   PAIL+P +F +      
Sbjct: 446 VSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTD 505

Query: 924 PIAARTLILVAKSVQNLANLVEFGA---KEPYMEGVNPFIKSNKH 965
           P  +RTL L++K+VQ L +L +  +   KE YM     F    K+
Sbjct: 506 PQTSRTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKY 550



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 33/129 (25%), Positives = 53/129 (41%), Gaps = 7/129 (5%)

Query: 590 LRQVSSLVLHIEEAHKLPV----KHFTNPYCNIYLNSVQVAKTHAREGQN-PVWSEEFVF 644
           LR   S+ + I EA  LP         + YC + L+  +V +T   E    P + E+F +
Sbjct: 8   LRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDF-Y 66

Query: 645 DDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 704
            ++P         + ++    +D  I  +  Q   LQK H  D WF L  H+       G
Sbjct: 67  CEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQL-QHVDADSEVQG 125

Query: 705 SLRVRARYS 713
            + +  R S
Sbjct: 126 KVHLELRLS 134


>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
          Length = 849

 Score =  122 bits (306), Expect = 2e-27
 Identities = 94/380 (24%), Positives = 177/380 (46%), Gaps = 35/380 (9%)

Query: 596 LVLHIEEAHKLPVKH--FTNPYCNIYL-----NSVQVAKTHAREGQNPVWSEEFVFDDL- 647
           LV+HI+  H LP+ +    +PY  + L     N  +  K   ++  NP ++E F F+   
Sbjct: 173 LVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVK-KKTSNPQFNEIFYFEVTR 231

Query: 648 -------------PPDINRFEITLS--NKTKKSKDPDILFMRCQLSRLQKGHATDEWFLL 692
                          DI + EI +   N     +D  +  ++  ++ L+   +   W+LL
Sbjct: 232 SSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLL 291

Query: 693 ----SSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQK------ELHVVYALS 742
               + +   K  + GSLR+   Y+ + ++P E Y   K L+L+            Y LS
Sbjct: 292 QPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILS 351

Query: 743 HVCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYM 802
            +C +D+      L+R+ LH          + + ++    +A T+FR  +LA+  +++ M
Sbjct: 352 EIC-RDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMM 410

Query: 803 KATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMA 862
           K     ++   LK  + +I +S +SCE+ P KL++ ++V  N  +L   + +L   I  +
Sbjct: 411 KIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKS 470

Query: 863 SEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSP 922
           S   P  +  I+  L++    ++P +  ++   VS FVFLR    A+++P  F++    P
Sbjct: 471 SMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHP 530

Query: 923 SPIAARTLILVAKSVQNLAN 942
                RTL L++K++Q L +
Sbjct: 531 DAQTIRTLTLISKTIQTLGS 550


>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
          Length = 2818

 Score =  112 bits (281), Expect = 1e-24
 Identities = 90/294 (30%), Positives = 147/294 (50%), Gaps = 15/294 (5%)

Query: 732  QKELHVVYALSHV--CGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFR 789
            Q EL +  AL++V  C Q   L A +L+ +F    L   LL  +  +E+ + D   TLFR
Sbjct: 1218 QGELPIAMALANVVPCSQWDEL-ARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFR 1276

Query: 790  ATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQ-----SCELSPSKLEKNEDVNTN 844
              +LAS +M    K     ++   L D +L+I+ +       S E+ P++LE +E +  N
Sbjct: 1277 GNSLASKIMTFCFKVYGATYLQKLL-DPLLRIVITSSDWQHVSFEVDPTRLEPSESLEEN 1335

Query: 845  LTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRL 904
              +LL +  +    I  +S   PP LR +  CL + V  ++P N+      V   +FLR 
Sbjct: 1336 QRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNS---IGAVGSAMFLRF 1392

Query: 905  ICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNK 964
            I PAI++P    I+   P P   R L L++K +Q++AN V F  KE +M   N F+KSN 
Sbjct: 1393 INPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEEHMRPFNDFVKSNF 1451

Query: 965  HRMIMFLDELGNVPELPDTTEHSRTDLS-RDLAALHEICVAHSDEL-RTLSNER 1016
                 F  ++ +     D   HS + +S  ++ ALH +   + +++ + LS+ R
Sbjct: 1452 DAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNNQEKIGQYLSSNR 1505


>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
          Length = 757

 Score =  108 bits (269), Expect = 3e-23
 Identities = 89/326 (27%), Positives = 147/326 (45%), Gaps = 46/326 (14%)

Query: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306

Query: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  ME ++K    Q++H 
Sbjct: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHG 366

Query: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426

Query: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482

Query: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P ++    ++  F
Sbjct: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDF 542

Query: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996
                 + +L D  E    DL R L+
Sbjct: 543 ------ITKLVDIEEKDELDLQRTLS 562


>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
          Length = 803

 Score =  108 bits (269), Expect = 3e-23
 Identities = 89/326 (27%), Positives = 147/326 (45%), Gaps = 46/326 (14%)

Query: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306

Query: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  ME ++K    Q++H 
Sbjct: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHG 366

Query: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426

Query: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482

Query: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P ++    ++  F
Sbjct: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDF 542

Query: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996
                 + +L D  E    DL R L+
Sbjct: 543 ------ITKLVDIEEKDELDLQRTLS 562


>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 731

 Score =  105 bits (263), Expect = 2e-22
 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)

Query: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234

Query: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  +E ++K    Q++H 
Sbjct: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294

Query: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354

Query: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410

Query: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P +    H+ +  
Sbjct: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466

Query: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996
           L +   + +L D  E    DL R L+
Sbjct: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490


>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 757

 Score =  105 bits (263), Expect = 2e-22
 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)

Query: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306

Query: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  +E ++K    Q++H 
Sbjct: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 366

Query: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426

Query: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482

Query: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P +    H+ +  
Sbjct: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 538

Query: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996
           L +   + +L D  E    DL R L+
Sbjct: 539 LKDF--ITKLVDIEEKDELDLQRTLS 562


>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 1 [Homo sapiens]
          Length = 731

 Score =  105 bits (263), Expect = 2e-22
 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)

Query: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 178 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 234

Query: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  +E ++K    Q++H 
Sbjct: 235 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 294

Query: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 295 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 354

Query: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 355 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 410

Query: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P +    H+ +  
Sbjct: 411 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 466

Query: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996
           L +   + +L D  E    DL R L+
Sbjct: 467 LKDF--ITKLVDIEEKDELDLQRTLS 490


>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
           isoform 2 [Homo sapiens]
          Length = 757

 Score =  105 bits (263), Expect = 2e-22
 Identities = 89/326 (27%), Positives = 148/326 (45%), Gaps = 46/326 (14%)

Query: 704 GSLRVRARYSMEKIMPEEEYSEFKELILQKELH-----------VVYALSHVCGQDRTLL 752
           GSL++  R   E ++P   Y     L+  +              +    S  C QD   +
Sbjct: 250 GSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQD---V 306

Query: 753 ASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMKATATQFVHH 812
           A+ LL++FL + L    L  L   E+S   E  TLFR+ +LAS  +E ++K    Q++H 
Sbjct: 307 ATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHG 366

Query: 813 ALKDSILKIMESKQSCELSPSKLE------------------KNEDVNTNLTHLLNILSE 854
            L   I K+ E K+  EL PSK+E                    +   T   HL  +LS 
Sbjct: 367 VLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSA 426

Query: 855 LVEKIFMASEILPPTLRYIYGCLQKSVQHKWP--TNTTMRTRVVSGFVFLRLICPAILNP 912
           L   +     ++  T R ++    + V+ ++P   +  +    V+ F+ LR   PAI++P
Sbjct: 427 LSRSVRACPAVVRATFRQLF----RRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSP 482

Query: 913 RMFNIISDSPSPIAARTLILVAKSVQNLANL--VEFGAKEPYMEGVNPFIKSNKHRMIMF 970
           ++F++         +RTL+L+AK+VQN+ N+      AKE +ME + P +    H+ +  
Sbjct: 483 KLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTV----HQGVAQ 538

Query: 971 LDELGNVPELPDTTEHSRTDLSRDLA 996
           L +   + +L D  E    DL R L+
Sbjct: 539 LKDF--ITKLVDIEEKDELDLQRTLS 562


>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
          Length = 2839

 Score =  105 bits (261), Expect = 3e-22
 Identities = 89/312 (28%), Positives = 147/312 (47%), Gaps = 30/312 (9%)

Query: 732  QKELHVVYALSHV--CGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFR 789
            Q EL +  AL++V  C Q   L A +L+ +F    L   LL  +  +E+ + D   TLFR
Sbjct: 1218 QGELPIAMALANVVPCSQWDEL-ARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFR 1276

Query: 790  ATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQ-----SCELSPSKLEKNEDVNTN 844
              +LAS +M    K     ++   L D +L+I+ +       S E+ P++LE +E +  N
Sbjct: 1277 GNSLASKIMTFCFKVYGATYLQKLL-DPLLRIVITSSDWQHVSFEVDPTRLEPSESLEEN 1335

Query: 845  LTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKWPTNTTMRTR---------- 894
              +LL +  +    I  +S   PP LR +  CL ++  H      T++ +          
Sbjct: 1336 QRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQ 1395

Query: 895  --------VVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLANLVEF 946
                     V   +FLR I PAI++P    I+   P P   R L L++K +Q++AN V F
Sbjct: 1396 RFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF 1455

Query: 947  GAKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLS-RDLAALHEICVAH 1005
              KE +M   N F+KSN      F  ++ +     D   HS + +S  ++ ALH +   +
Sbjct: 1456 -TKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRLLWNN 1514

Query: 1006 SDEL-RTLSNER 1016
             +++ + LS+ R
Sbjct: 1515 QEKIGQYLSSNR 1526


>gi|158631203 dual adaptor of phosphotyrosine and
           3-phosphoinositides [Homo sapiens]
          Length = 280

 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 67/233 (28%), Positives = 116/233 (49%), Gaps = 22/233 (9%)

Query: 351 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 410
           W+HG +++  A  LL++ G   S+L+R S+ T G YSL  R  ++++ F +  T    F 
Sbjct: 35  WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYT-GYSFK 93

Query: 411 MGGRYYNSIGDIIDHYRKEQIVEG-----YYLKEPVPMQDQEQVLNDTVDGKEIYNTIRR 465
            G   ++S+ D + H+  + ++         LK P P + +E  + ++V       T R 
Sbjct: 94  FGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGR- 152

Query: 466 KTKDAFYKNI----VKKGYLLKK-GKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLI 520
            T+D           K+GYL K+ G  K WK  +F L  +  +L YF+ ++ + +P  ++
Sbjct: 153 -TEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRN--ELKYFK-DQMSPEPIRIL 208

Query: 521 DLSVCSVYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQ 573
           DL+ CS  V  D    R NCF +V    +     FY   +T  +A++W+K L+
Sbjct: 209 DLTECSA-VQFDYSQERVNCFCLVFPFRT-----FYLCAKTGVEADEWIKILR 255



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 28/78 (35%), Positives = 42/78 (53%), Gaps = 1/78 (1%)

Query: 181 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240
           WYHG L R  AE  L   G  GSYL+R+S+   G + LS  ++ + V HF +      + 
Sbjct: 35  WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAK-DSVKHFHVEYTGYSFK 93

Query: 241 IGGRRFSSLSDLIGYYSH 258
            G   FSSL D + ++++
Sbjct: 94  FGFNEFSSLKDFVKHFAN 111


>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
          Length = 217

 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 42/156 (26%), Positives = 83/156 (53%), Gaps = 13/156 (8%)

Query: 295 DTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHG 354
           ++DE++F KGD   + N +ED   W        +G I ++ +        PH    W+ G
Sbjct: 13  ESDELAFNKGDTLKILN-MEDDQNWYKAELRGVEGFIPKNYIRV-----KPHP---WYSG 63

Query: 355 KISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGR 414
           +IS+Q A  +LM    + +FL+R S+++PG++S+     + +Q FK+    + ++ +   
Sbjct: 64  RISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEE 123

Query: 415 YYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQVL 450
            +NS+ +++D YR   I +    K  + ++D+E +L
Sbjct: 124 KFNSLNELVDFYRTTTIAK----KRQIFLRDEEPLL 155



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 39/138 (28%), Positives = 71/138 (51%), Gaps = 3/138 (2%)

Query: 181 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRII-AMCGDY 239
           WY G++ R +AEE L +    G++LIRES+  PG F +S ++  + V HF+++    G Y
Sbjct: 60  WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVS-VNYGDQVQHFKVLREASGKY 118

Query: 240 YIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKVPDTDEI 299
           ++   +F+SL++L+ +Y   +   K +  L    P          +A   ++   D  ++
Sbjct: 119 FLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFS-AQDPSQL 177

Query: 300 SFLKGDMFIVHNELEDGW 317
           SF +GD+  V    +  W
Sbjct: 178 SFRRGDIIEVLERPDPHW 195


>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
          Length = 1265

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 80/337 (23%), Positives = 138/337 (40%), Gaps = 90/337 (26%)

Query: 166 EEEVAIPLTAPPTN-----QWYHGKLDRTIAEERLRQ------AGKSGSYLIRESDRRPG 214
           EEEV  P   PPT      +W+H K+++  + E+L Q       GK G++L+RES+  P 
Sbjct: 514 EEEV--PQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPN 571

Query: 215 SFVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAP 274
            + LSF  +   V H RI +                            ++G  L Y +  
Sbjct: 572 DYTLSFW-RSGRVQHCRIRST---------------------------MEGGTLKYYL-- 601

Query: 275 PEPVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVED 334
                                TD ++F      I H          T+LR  E  L + D
Sbjct: 602 ---------------------TDNLTFSSIYALIQHYR-------ETHLRCAEFELRLTD 633

Query: 335 LVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNE 394
            V       +PHE K W++  +S+ EA ++LM + +  +FL+R  + +   Y++ FR   
Sbjct: 634 PVPN----PNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGS-DSYAITFRARG 688

Query: 395 NIQRFKICPTPNNQFMMG-GRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQ-----DQEQ 448
            ++  +I       F++G   Y+ S+ +++ +Y K  +     L+ PV  +     + E+
Sbjct: 689 KVKHCRI-NRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLRYPVTPELLERYNMER 747

Query: 449 VLNDT-------VDGKEIYNTIRRKTKDAFYKNIVKK 478
            +N         VD  EI  ++ ++T  A Y    K+
Sbjct: 748 DINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKR 784



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 53/241 (21%), Positives = 102/241 (42%), Gaps = 36/241 (14%)

Query: 277 PVEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMW-------------VTNL 323
           P   + R + I+ + K+    ++     D    H +  + +MW             + + 
Sbjct: 442 PSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADA 501

Query: 324 RTDEQGLIVEDLVEEVGREEDP---HEGKIWFHGKISKQEAYNLLM------TVGQVCSF 374
           +      I + + EEV ++  P   H G+ WFH K+ K+ +   L+      T G+  +F
Sbjct: 502 KLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTF 561

Query: 375 LVRPSDNTPGDYSLYFRTNENIQRFKICPTPN----NQFMMGGRYYNSIGDIIDHYRKEQ 430
           LVR S+  P DY+L F  +  +Q  +I  T        ++     ++SI  +I HYR+  
Sbjct: 562 LVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTDNLTFSSIYALIQHYRETH 621

Query: 431 IVEGYY---LKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVKKG-YLLKKGK 486
           +    +   L +PVP  +  +           Y+++ R   +     I + G +L++K +
Sbjct: 622 LRCAEFELRLTDPVPNPNPHE------SKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKRE 675

Query: 487 G 487
           G
Sbjct: 676 G 676


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 47/167 (28%), Positives = 82/167 (49%), Gaps = 14/167 (8%)

Query: 284 VRAILPYT-KVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGRE 342
           + AI  Y  K    DE+SF +GD+  V NE E    W       + G I ++ +E     
Sbjct: 1   MEAIAKYDFKATADDELSFKRGDILKVLNE-ECDQNWYKAELNGKDGFIPKNYIEM---- 55

Query: 343 EDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKIC 402
             PH    WF GKI + +A  +L       +FL+R S++ PGD+SL  +   ++Q FK+ 
Sbjct: 56  -KPHP---WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVL 111

Query: 403 PTPNNQFMMGGRYYNSIGDIIDHYRKEQIVEGYYLKEPVPMQDQEQV 449
                ++ +    +NS+ +++D++R   +       + + ++D EQV
Sbjct: 112 RDGAGKYFLWVVKFNSLNELVDYHRSTSVSR----NQQIFLRDIEQV 154



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 43/140 (30%), Positives = 71/140 (50%), Gaps = 9/140 (6%)

Query: 181 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIA-MCGDY 239
           W+ GK+ R  AEE L +    G++LIRES+  PG F LS +   N V HF+++    G Y
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLS-VKFGNDVQHFKVLRDGAGKY 118

Query: 240 YIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPV--APPEPVEDRRRVRAILPYTKVPDTD 297
           ++   +F+SL++L+ Y+   S     +  L  +   P +P      V+A+  +    D  
Sbjct: 119 FLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPT----YVQALFDFDPQED-G 173

Query: 298 EISFLKGDMFIVHNELEDGW 317
           E+ F +GD   V +  +  W
Sbjct: 174 ELGFRRGDFIHVMDNSDPNW 193


>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
          Length = 612

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 71/257 (27%), Positives = 117/257 (45%), Gaps = 38/257 (14%)

Query: 181 WYHGKLDRTIAEERLRQAGKS-GSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIA-MCGD 238
           ++ G + R  AE+ L Q G S G YL+R+S    G F LS ++     +H+ I   + G 
Sbjct: 15  FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALS-VAHGRKAHHYTIERELNGT 73

Query: 239 YYI-GGRRFSSLSDLIGYYSHVS----CLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKV 293
           Y I GGR  +S +DL  Y+S  S    CLLK      P   P+ V+              
Sbjct: 74  YAIAGGRTHASPADLCHYHSQESDGLVCLLKK-----PFNRPQGVQ-------------- 114

Query: 294 PDTDEISFLKGDMFIVHNELEDGWMWVTNLRTD--EQGLIVEDLVEEVGREEDPHEGKIW 351
           P T     LK ++  +   ++  W    NL+    EQ +I +    E       HE   W
Sbjct: 115 PKTGPFEDLKENL--IREYVKQTW----NLQGQALEQAIISQKPQLEKLIATTAHEKMPW 168

Query: 352 FHGKISKQEAYNLLMTVGQV-CSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 410
           FHGKIS++E+  +++   +    FL+R  DN  G Y+L       +  ++I      +  
Sbjct: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTGKLS 227

Query: 411 M-GGRYYNSIGDIIDHY 426
           +  G+ ++++  +++HY
Sbjct: 228 IPEGKKFDTLWQLVEHY 244



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 32/94 (34%), Positives = 49/94 (52%), Gaps = 5/94 (5%)

Query: 168 EVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGK-SGSYLIRESDRRPGSFVLSFLSQMNV 226
           E  I  TA     W+HGK+ R  +E+ +    K +G +LIR  D   GS+ L  L +  V
Sbjct: 155 EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKV 213

Query: 227 VNHFRIIA-MCGDYYI-GGRRFSSLSDLIGYYSH 258
           + H+RI     G   I  G++F +L  L+ +YS+
Sbjct: 214 L-HYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSY 246


>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
          Length = 635

 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 71/257 (27%), Positives = 117/257 (45%), Gaps = 38/257 (14%)

Query: 181 WYHGKLDRTIAEERLRQAGKS-GSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIA-MCGD 238
           ++ G + R  AE+ L Q G S G YL+R+S    G F LS ++     +H+ I   + G 
Sbjct: 15  FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALS-VAHGRKAHHYTIERELNGT 73

Query: 239 YYI-GGRRFSSLSDLIGYYSHVS----CLLKGEKLLYPVAPPEPVEDRRRVRAILPYTKV 293
           Y I GGR  +S +DL  Y+S  S    CLLK      P   P+ V+              
Sbjct: 74  YAIAGGRTHASPADLCHYHSQESDGLVCLLKK-----PFNRPQGVQ-------------- 114

Query: 294 PDTDEISFLKGDMFIVHNELEDGWMWVTNLRTD--EQGLIVEDLVEEVGREEDPHEGKIW 351
           P T     LK ++  +   ++  W    NL+    EQ +I +    E       HE   W
Sbjct: 115 PKTGPFEDLKENL--IREYVKQTW----NLQGQALEQAIISQKPQLEKLIATTAHEKMPW 168

Query: 352 FHGKISKQEAYNLLMTVGQV-CSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 410
           FHGKIS++E+  +++   +    FL+R  DN  G Y+L       +  ++I      +  
Sbjct: 169 FHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTGKLS 227

Query: 411 M-GGRYYNSIGDIIDHY 426
           +  G+ ++++  +++HY
Sbjct: 228 IPEGKKFDTLWQLVEHY 244



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 32/94 (34%), Positives = 49/94 (52%), Gaps = 5/94 (5%)

Query: 168 EVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGK-SGSYLIRESDRRPGSFVLSFLSQMNV 226
           E  I  TA     W+HGK+ R  +E+ +    K +G +LIR  D   GS+ L  L +  V
Sbjct: 155 EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKV 213

Query: 227 VNHFRIIA-MCGDYYI-GGRRFSSLSDLIGYYSH 258
           + H+RI     G   I  G++F +L  L+ +YS+
Sbjct: 214 L-HYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSY 246


>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
           [Homo sapiens]
          Length = 593

 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 60/208 (28%), Positives = 97/208 (46%), Gaps = 40/208 (19%)

Query: 351 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 410
           WFHG +S +EA  LL   G+  SFLVR S + PGD+ L  RT ++        +     M
Sbjct: 112 WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVM 171

Query: 411 M----------GGRYYNSIGDIIDHYRKEQIVE--GYYLKEPVPMQDQEQVLNDT-VDGK 457
           +          GG  ++S+ D+++HY+K  +VE  G  L+        +Q LN T ++  
Sbjct: 172 IRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQ-------LKQPLNTTRINAA 224

Query: 458 EIYNTIRRKTKDAFYKNIVKKGYLLKKGKGKRWKNLYFILEGSDAQLIYFESE------K 511
           EI + +R  +K A   + VK+G+         W+  +  L+  + +L+Y   E      K
Sbjct: 225 EIESRVRELSKLAETTDKVKQGF---------WEE-FETLQQQECKLLYSRKEGQRQENK 274

Query: 512 RATKPKGLIDLSVCSVYVVHDSLFGRPN 539
              + K ++      V V+HD   G PN
Sbjct: 275 NKNRYKNILPFDHTRV-VLHD---GDPN 298



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 41/126 (32%), Positives = 63/126 (50%), Gaps = 8/126 (6%)

Query: 351 WFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFM 410
           WFH  I+  EA NLL+T G   SFL RPS + PGD++L  R N  +   KI  T +   +
Sbjct: 6   WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDL 65

Query: 411 MGGRYYNSIGDIIDHYR------KEQIVEGYYLKEPVPMQD--QEQVLNDTVDGKEIYNT 462
            GG  + ++ +++ +Y       KE+  +   LK P+   D   E+  +  + GKE    
Sbjct: 66  YGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKL 125

Query: 463 IRRKTK 468
           +  K K
Sbjct: 126 LTEKGK 131



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 38/101 (37%), Positives = 52/101 (51%), Gaps = 12/101 (11%)

Query: 168 EVAIPLTA--PPTNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLS--- 222
           E+  PL    P + +W+HG L    AE+ L + GK GS+L+RES   PG FVLS  +   
Sbjct: 97  ELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDD 156

Query: 223 ------QMNVVNHFRIIAMCGDYYI-GGRRFSSLSDLIGYY 256
                   + V H  I      Y + GG RF SL+DL+ +Y
Sbjct: 157 KGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHY 197



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 37/111 (33%), Positives = 56/111 (50%), Gaps = 9/111 (8%)

Query: 178 TNQWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCG 237
           + +W+H  +    AE  L   G  GS+L R S   PG F LS + +   V H + I   G
Sbjct: 3   SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLS-VRRNGAVTHIK-IQNTG 60

Query: 238 DYY--IGGRRFSSLSDLIGYYSHVSCLLKGE-----KLLYPVAPPEPVEDR 281
           DYY   GG +F++L++L+ YY      LK +     +L YP+   +P  +R
Sbjct: 61  DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSER 111


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 42/139 (30%), Positives = 73/139 (52%), Gaps = 12/139 (8%)

Query: 297 DEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKI 356
           +++SF KGD  +V  E  + W    +L T ++G I  + V  V    D  E + WF   I
Sbjct: 95  EDLSFQKGDQMVVLEESGEWWK-ARSLATRKEGYIPSNYVARV----DSLETEEWFFKGI 149

Query: 357 SKQEAYNLLMTVGQVC-SFLVRPSDNTPGDYSLYF-----RTNENIQRFKICPTPNNQFM 410
           S+++A   L+  G +  SF++R S+ T G YSL       R  + ++ +KI    N  F 
Sbjct: 150 SRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFY 209

Query: 411 MGGR-YYNSIGDIIDHYRK 428
           +  R  ++++ +++DHY+K
Sbjct: 210 ISPRSTFSTLQELVDHYKK 228



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 7/86 (8%)

Query: 178 TNQWYHGKLDRTIAEERLRQAGKS-GSYLIRESDRRPGSFVLSFLS----QMNVVNHFRI 232
           T +W+   + R  AE +L   G   GS++IR+S+   GS+ LS       Q + V H++I
Sbjct: 141 TEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKI 200

Query: 233 IAM-CGDYYIGGR-RFSSLSDLIGYY 256
             +  G +YI  R  FS+L +L+ +Y
Sbjct: 201 RTLDNGGFYISPRSTFSTLQELVDHY 226


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 40/138 (28%), Positives = 70/138 (50%), Gaps = 11/138 (7%)

Query: 296 TDEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGK 355
           T+++SF KG+ F + N  E  W    ++ T + G I  + V       D  + + W+ GK
Sbjct: 107 TEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPA----DSIQAEEWYFGK 162

Query: 356 ISKQEAYNLLMTVG-QVCSFLVRPSDNTPGDYSLYFR-----TNENIQRFKICPTPNNQF 409
           + +++A  LL+  G Q   FLVR S+ T G YSL  R       +N++ +KI    N  +
Sbjct: 163 MGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGY 222

Query: 410 MMGGR-YYNSIGDIIDHY 426
            +  R  ++++  ++ HY
Sbjct: 223 YITTRAQFDTLQKLVKHY 240



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 35/121 (28%), Positives = 55/121 (45%), Gaps = 8/121 (6%)

Query: 164 YEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAG-KSGSYLIRESDRRPGSFVLSFLS 222
           Y       P  +    +WY GK+ R  AE  L   G + G +L+RES+   G++ LS   
Sbjct: 141 YIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRD 200

Query: 223 QMNV----VNHFRIIAM-CGDYYIGGR-RFSSLSDLIGYYS-HVSCLLKGEKLLYPVAPP 275
              +    V H++I  +  G YYI  R +F +L  L+ +Y+ H   L      + P   P
Sbjct: 201 WDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKP 260

Query: 276 E 276
           +
Sbjct: 261 Q 261


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 41/142 (28%), Positives = 72/142 (50%), Gaps = 21/142 (14%)

Query: 297 DEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKI 356
           D+++F KG+ F + N  E  W    +L + + G I  + V  V    D  + + W+ GKI
Sbjct: 94  DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV----DSIQAEEWYFGKI 149

Query: 357 SKQEAYNLLMTVGQVC-SFLVRPSDNTPGDYSLYFR-----TNENIQRFKICPTPNNQFM 410
            +++A   L++ G    +FL+R S+ T G YSL  R       ++++ +KI      +  
Sbjct: 150 GRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI-----RKLD 204

Query: 411 MGGRY------YNSIGDIIDHY 426
           MGG Y      +NS+ +++ HY
Sbjct: 205 MGGYYITTRVQFNSVQELVQHY 226



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 32/96 (33%), Positives = 55/96 (57%), Gaps = 7/96 (7%)

Query: 172 PLTAPPTNQWYHGKLDRTIAEERLRQAGK-SGSYLIRESDRRPGSFVLSF----LSQMNV 226
           P+ +    +WY GK+ R  AE +L   G   G++LIRES+   G++ LS      ++ + 
Sbjct: 135 PVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH 194

Query: 227 VNHFRIIAM-CGDYYIGGR-RFSSLSDLIGYYSHVS 260
           V H++I  +  G YYI  R +F+S+ +L+ +Y  V+
Sbjct: 195 VKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 41/142 (28%), Positives = 72/142 (50%), Gaps = 21/142 (14%)

Query: 297 DEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKI 356
           D+++F KG+ F + N  E  W    +L + + G I  + V  V    D  + + W+ GKI
Sbjct: 94  DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV----DSIQAEEWYFGKI 149

Query: 357 SKQEAYNLLMTVGQVC-SFLVRPSDNTPGDYSLYFR-----TNENIQRFKICPTPNNQFM 410
            +++A   L++ G    +FL+R S+ T G YSL  R       ++++ +KI      +  
Sbjct: 150 GRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI-----RKLD 204

Query: 411 MGGRY------YNSIGDIIDHY 426
           MGG Y      +NS+ +++ HY
Sbjct: 205 MGGYYITTRVQFNSVQELVQHY 226



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 32/96 (33%), Positives = 55/96 (57%), Gaps = 7/96 (7%)

Query: 172 PLTAPPTNQWYHGKLDRTIAEERLRQAGK-SGSYLIRESDRRPGSFVLSF----LSQMNV 226
           P+ +    +WY GK+ R  AE +L   G   G++LIRES+   G++ LS      ++ + 
Sbjct: 135 PVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH 194

Query: 227 VNHFRIIAM-CGDYYIGGR-RFSSLSDLIGYYSHVS 260
           V H++I  +  G YYI  R +F+S+ +L+ +Y  V+
Sbjct: 195 VKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,787,713
Number of Sequences: 37866
Number of extensions: 2187445
Number of successful extensions: 17401
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 188
Number of HSP's successfully gapped in prelim test: 585
Number of HSP's that attempted gapping in prelim test: 12090
Number of HSP's gapped (non-prelim): 3490
length of query: 1047
length of database: 18,247,518
effective HSP length: 113
effective length of query: 934
effective length of database: 13,968,660
effective search space: 13046728440
effective search space used: 13046728440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.