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Search of human proteins with 4506323
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506323 receptor-type protein tyrosine phosphatase O isoform
b precursor [Homo sapiens]
(1188 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506323 receptor-type protein tyrosine phosphatase O isoform ... 2414 0.0
gi|13677214 receptor-type protein tyrosine phosphatase O isoform... 2399 0.0
gi|13677220 receptor-type protein tyrosine phosphatase O isoform... 773 0.0
gi|13677216 receptor-type protein tyrosine phosphatase O isoform... 773 0.0
gi|13677222 receptor-type protein tyrosine phosphatase O isoform... 758 0.0
gi|13677218 receptor-type protein tyrosine phosphatase O isoform... 758 0.0
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 306 1e-82
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 306 1e-82
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 286 8e-77
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 284 3e-76
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 279 1e-74
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 279 1e-74
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 228 3e-59
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 228 3e-59
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 225 2e-58
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 225 2e-58
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 225 2e-58
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 225 2e-58
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 224 4e-58
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 223 6e-58
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 223 6e-58
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 223 6e-58
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 223 6e-58
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 222 1e-57
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 222 1e-57
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 221 2e-57
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 221 2e-57
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 221 2e-57
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 219 1e-56
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 219 1e-56
>gi|4506323 receptor-type protein tyrosine phosphatase O isoform b
precursor [Homo sapiens]
Length = 1188
Score = 2414 bits (6257), Expect = 0.0
Identities = 1188/1188 (100%), Positives = 1188/1188 (100%)
Query: 1 MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI 60
MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI
Sbjct: 1 MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI 60
Query: 61 TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP 120
TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP
Sbjct: 61 TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP 120
Query: 121 VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH 180
VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH
Sbjct: 121 VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH 180
Query: 181 WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW 240
WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW
Sbjct: 181 WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW 240
Query: 241 EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW 300
EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW
Sbjct: 241 EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW 300
Query: 301 DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG 360
DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG
Sbjct: 301 DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG 360
Query: 361 FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF 420
FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF
Sbjct: 361 FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF 420
Query: 421 YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR 480
YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR
Sbjct: 421 YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR 480
Query: 481 LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP 540
LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP
Sbjct: 481 LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP 540
Query: 541 LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP 600
LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP
Sbjct: 541 LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP 600
Query: 601 AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL 660
AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL
Sbjct: 601 AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL 660
Query: 661 SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK 720
SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK
Sbjct: 661 SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK 720
Query: 721 LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI
Sbjct: 721 LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
Query: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT 840
SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT
Sbjct: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT 840
Query: 841 LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIK 900
LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIK
Sbjct: 841 LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIK 900
Query: 901 DMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEE 960
DMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEE
Sbjct: 901 DMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEE 960
Query: 961 GADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCD 1020
GADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCD
Sbjct: 961 GADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCD 1020
Query: 1021 HYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTA 1080
HYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTA
Sbjct: 1021 HYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTA 1080
Query: 1081 NAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLV 1140
NAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLV
Sbjct: 1081 NAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLV 1140
Query: 1141 SEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 1188
SEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Sbjct: 1141 SEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 1188
>gi|13677214 receptor-type protein tyrosine phosphatase O isoform a
precursor [Homo sapiens]
Length = 1216
Score = 2399 bits (6218), Expect = 0.0
Identities = 1188/1216 (97%), Positives = 1188/1216 (97%), Gaps = 28/1216 (2%)
Query: 1 MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI 60
MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI
Sbjct: 1 MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI 60
Query: 61 TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP 120
TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP
Sbjct: 61 TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP 120
Query: 121 VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH 180
VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH
Sbjct: 121 VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH 180
Query: 181 WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW 240
WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW
Sbjct: 181 WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW 240
Query: 241 EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW 300
EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW
Sbjct: 241 EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW 300
Query: 301 DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG 360
DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG
Sbjct: 301 DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG 360
Query: 361 FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF 420
FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF
Sbjct: 361 FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF 420
Query: 421 YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR 480
YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR
Sbjct: 421 YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR 480
Query: 481 LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP 540
LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP
Sbjct: 481 LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP 540
Query: 541 LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP 600
LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP
Sbjct: 541 LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP 600
Query: 601 AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL 660
AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL
Sbjct: 601 AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL 660
Query: 661 SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK 720
SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK
Sbjct: 661 SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK 720
Query: 721 LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI
Sbjct: 721 LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
Query: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT 840
SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT
Sbjct: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT 840
Query: 841 LIILRKKHLQMARECGAGTFVNFASLERDGKLPYN------------------------- 875
LIILRKKHLQMARECGAGTFVNFASLERDGKLPYN
Sbjct: 841 LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFY 900
Query: 876 ---WSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLP 932
WSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLP
Sbjct: 901 INPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLP 960
Query: 933 LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRND 992
LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRND
Sbjct: 961 LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRND 1020
Query: 993 FWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRH 1052
FWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRH
Sbjct: 1021 FWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRH 1080
Query: 1053 FRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGV 1112
FRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGV
Sbjct: 1081 FRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGV 1140
Query: 1113 GRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK 1172
GRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
Sbjct: 1141 GRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK 1200
Query: 1173 QQFCISDVIYENVSKS 1188
QQFCISDVIYENVSKS
Sbjct: 1201 QQFCISDVIYENVSKS 1216
>gi|13677220 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 773 bits (1995), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 812 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 871
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
Query: 872 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 931
LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL
Sbjct: 61 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
Query: 932 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 991
PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN
Sbjct: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
Query: 992 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 1051
DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR
Sbjct: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
Query: 1052 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 1111
HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG
Sbjct: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
Query: 1112 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 1171
VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
Sbjct: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
Query: 1172 KQQFCISDVIYENVSKS 1188
KQQFCISDVIYENVSKS
Sbjct: 361 KQQFCISDVIYENVSKS 377
>gi|13677216 receptor-type protein tyrosine phosphatase O isoform d
precursor [Homo sapiens]
Length = 377
Score = 773 bits (1995), Expect = 0.0
Identities = 377/377 (100%), Positives = 377/377 (100%)
Query: 812 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 871
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
Query: 872 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 931
LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL
Sbjct: 61 LPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 120
Query: 932 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 991
PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN
Sbjct: 121 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 180
Query: 992 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 1051
DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR
Sbjct: 181 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 240
Query: 1052 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 1111
HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG
Sbjct: 241 HFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAG 300
Query: 1112 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 1171
VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK
Sbjct: 301 VGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKK 360
Query: 1172 KQQFCISDVIYENVSKS 1188
KQQFCISDVIYENVSKS
Sbjct: 361 KQQFCISDVIYENVSKS 377
>gi|13677222 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 758 bits (1956), Expect = 0.0
Identities = 377/405 (93%), Positives = 377/405 (93%), Gaps = 28/405 (6%)
Query: 812 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 871
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
Query: 872 LPYNW----------------------------SKNGLKKRKLTNPVQLDDFDAYIKDMA 903
LPYNW SKNGLKKRKLTNPVQLDDFDAYIKDMA
Sbjct: 61 LPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMA 120
Query: 904 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 963
KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD
Sbjct: 121 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 180
Query: 964 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 1023
YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
Sbjct: 181 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 240
Query: 1024 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 1083
PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA
Sbjct: 241 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 300
Query: 1084 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 1143
ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM
Sbjct: 301 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 360
Query: 1144 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 1188
RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Sbjct: 361 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 405
>gi|13677218 receptor-type protein tyrosine phosphatase O isoform c
precursor [Homo sapiens]
Length = 405
Score = 758 bits (1956), Expect = 0.0
Identities = 377/405 (93%), Positives = 377/405 (93%), Gaps = 28/405 (6%)
Query: 812 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 871
MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK
Sbjct: 1 MVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGK 60
Query: 872 LPYNW----------------------------SKNGLKKRKLTNPVQLDDFDAYIKDMA 903
LPYNW SKNGLKKRKLTNPVQLDDFDAYIKDMA
Sbjct: 61 LPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMA 120
Query: 904 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 963
KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD
Sbjct: 121 KDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGAD 180
Query: 964 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 1023
YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW
Sbjct: 181 YINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 240
Query: 1024 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 1083
PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA
Sbjct: 241 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAA 300
Query: 1084 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 1143
ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM
Sbjct: 301 ESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEM 360
Query: 1144 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 1188
RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS
Sbjct: 361 RSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVSKS 405
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 306 bits (783), Expect = 1e-82
Identities = 177/423 (41%), Positives = 252/423 (59%), Gaps = 27/423 (6%)
Query: 783 LLPATAYNCSVTSFSH---------DSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
L P TAY S+ +F+ P + TE P I ++ L
Sbjct: 1789 LKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSA-GLFL 1847
Query: 834 IGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQ 891
IG+L+ V L+I R+K + RE + S+ RD L + + RK + P++
Sbjct: 1848 IGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPIK 1902
Query: 892 LDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRV 951
++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +RV
Sbjct: 1903 INQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRV 1962
Query: 952 RLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQC 1011
+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQC
Sbjct: 1963 KLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQC 2022
Query: 1012 NEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHFN 1068
EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF+
Sbjct: 2023 VEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFH 2082
Query: 1069 YTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQ 1126
YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+LQ
Sbjct: 2083 YTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQ 2140
Query: 1127 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIYE 1183
+ + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IYE
Sbjct: 2141 QLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYE 2200
Query: 1184 NVS 1186
NV+
Sbjct: 2201 NVN 2203
Score = 31.2 bits (69), Expect = 6.1
Identities = 41/207 (19%), Positives = 75/207 (36%), Gaps = 23/207 (11%)
Query: 328 SETEKSTSGSFSFFPV---QMILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHE- 383
S T S SF + + +TW P T ++ F + + T + + E
Sbjct: 1475 SRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEG 1534
Query: 384 -FVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVH 442
V L+ Y+ +V T S S Y P + +K Q++
Sbjct: 1535 RIVYGLRPGRSYQFNVKTVSGD------------SWKTYSKPIFGSVRTKPDKIQNLHCR 1582
Query: 443 VLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPG 502
+ST SW +++ + + Q+ + S++LEK+ S I LVP
Sbjct: 1583 PQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKE------KSLLNIMMLVPH 1636
Query: 503 AQYQVVIYLRKGPLIGPPSDPVTFAIV 529
+Y V I ++ + + T ++
Sbjct: 1637 KRYLVSIKVQSAGMTSEVVEDSTITMI 1663
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 306 bits (783), Expect = 1e-82
Identities = 177/423 (41%), Positives = 252/423 (59%), Gaps = 27/423 (6%)
Query: 783 LLPATAYNCSVTSFSH---------DSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
L P TAY S+ +F+ P + TE P I ++ L
Sbjct: 1571 LKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSA-GLFL 1629
Query: 834 IGLLL--VTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQ 891
IG+L+ V L+I R+K + RE + S+ RD L + + RK + P++
Sbjct: 1630 IGMLVAVVALLICRQK-VSHGRERPSARL----SIRRDRPLSVHLNLGQKGNRKTSCPIK 1684
Query: 892 LDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRV 951
++ F+ + + DS+Y S ++EELK +G + A LP NR KNRY NILPYD +RV
Sbjct: 1685 INQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRV 1744
Query: 952 RLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQC 1011
+L +++++ +DYINA+YIPG N +EYI TQGPLP T++DFWKMV +Q IVM+TQC
Sbjct: 1745 KLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQC 1804
Query: 1012 NEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI---NYADEMQDVMHFN 1068
EK RVKCDHYWP ++ + YGD+ ++M+SE +W R F+I D + + HF+
Sbjct: 1805 VEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLIRHFH 1864
Query: 1069 YTAWPDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQ 1126
YT WPDHGVP +S++QFV VR +S GP ++HCSAGVGRTGTFIALDR+LQ
Sbjct: 1865 YTVWPDHGVP--ETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRILQ 1922
Query: 1127 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK---QQFCISDVIYE 1183
+ + VDI G V ++R +R+ MVQTE QY+++HQCV+ + +K +Q IYE
Sbjct: 1923 QLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPIYE 1982
Query: 1184 NVS 1186
NV+
Sbjct: 1983 NVN 1985
Score = 31.2 bits (69), Expect = 6.1
Identities = 41/207 (19%), Positives = 75/207 (36%), Gaps = 23/207 (11%)
Query: 328 SETEKSTSGSFSFFPV---QMILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHE- 383
S T S SF + + +TW P T ++ F + + T + + E
Sbjct: 1257 SRTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEG 1316
Query: 384 -FVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVH 442
V L+ Y+ +V T S S Y P + +K Q++
Sbjct: 1317 RIVYGLRPGRSYQFNVKTVSGD------------SWKTYSKPIFGSVRTKPDKIQNLHCR 1364
Query: 443 VLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPG 502
+ST SW +++ + + Q+ + S++LEK+ S I LVP
Sbjct: 1365 PQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFSRKLEKE------KSLLNIMMLVPH 1418
Query: 503 AQYQVVIYLRKGPLIGPPSDPVTFAIV 529
+Y V I ++ + + T ++
Sbjct: 1419 KRYLVSIKVQSAGMTSEVVEDSTITMI 1445
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 286 bits (732), Expect = 8e-77
Identities = 156/388 (40%), Positives = 222/388 (57%), Gaps = 20/388 (5%)
Query: 813 VTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQ-----------MARECGAGTFV 861
++E +++ L ILS +L+G + +R+K + + + +
Sbjct: 1899 LSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLI 1958
Query: 862 NFASLE-RDGKLPYNWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLI 920
A LE +D +L L RK P+ F +++++ +++ KF +F EL
Sbjct: 1959 TVADLELKDERLT-----RLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKF 2013
Query: 921 GLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYI 980
D+ ADLP NR KNR+ NI PY+ +RV+L++ G+DYINA+YI GY P E+I
Sbjct: 2014 LQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFI 2073
Query: 981 ATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEM 1039
ATQGPLP T DFW+MV + +++ +VMLTQC EK R++C YWP +P+ +GDI +
Sbjct: 2074 ATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITK 2133
Query: 1040 ISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATK 1099
+ E+ Q DW R +I + V N+TAWP+HGVP +A ++ FV +VR
Sbjct: 2134 LMEDVQIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSA--PLIHFVKLVRASRAH 2191
Query: 1100 SKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIF 1159
PMI+HCSAGVGRTG FIALD L QHI DH+FVDI GLV+E+RS RM MVQ QYIF
Sbjct: 2192 DTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIYGLVAELRSERMCMVQNLAQYIF 2251
Query: 1160 IHQCVQLMWMKKKQQFCISDVIYENVSK 1187
+HQC+ + K I V Y + K
Sbjct: 2252 LHQCILDLLSNKGSNQPICFVNYSALQK 2279
Score = 44.3 bits (103), Expect = 7e-04
Identities = 88/434 (20%), Positives = 168/434 (38%), Gaps = 56/434 (12%)
Query: 345 MILTWLPPKPPTA-FDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSS 403
++L W PP+ P + I+ + + + + + LK+ KYK+ V +
Sbjct: 585 ILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTH 644
Query: 404 SGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNST 463
G +S ++ ++ S + E PQ V V +++ + W S E N
Sbjct: 645 VG-----ESSLSEENDIFVRTSED---EPESSPQDVEVIDVTADEIRLKW-SPPEKPNGI 695
Query: 464 IVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVI--YLR--KGPLIGP 519
I++ L + ++ Y +++ I+ NL P Y + + Y R G +
Sbjct: 696 IIAYEVLY-------KNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSS 748
Query: 520 PSDPVTFAIVPTGIKDLMLYP-LGPTAVVLSWTRPYL--GVFRKYVVEMFYFNPATMTSE 576
T VP + + Y + + LS+ P G+ +KY + Y + E
Sbjct: 749 LLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTI---YLKRSNGNEE 805
Query: 577 WTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAP- 635
T T SLT ++++ L Y V+ T + S ++ AP +P
Sbjct: 806 RTIN-----TTSLTQNIKV--LKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPP 858
Query: 636 EITSVEYFNSL-LYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLP 694
+ SV+ + + + +SW + + +L++ V + +K T NV L L
Sbjct: 859 QDFSVKQLSGVTVKLSWQPPLEPNGI----ILYYTVYVWNRSSLK---TINVTETSLELS 911
Query: 695 PGDI---YNLSVTACTERGSNTSMLRLVKLEPA------PPKSLFAVNKTQTSVTLLWV- 744
D Y+ VTA T G + ++ + PPK ++ N + +S+ L W
Sbjct: 912 DLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTP 971
Query: 745 ---EEGVADFFEVF 755
G+ ++ V+
Sbjct: 972 PSKPNGIIQYYSVY 985
Score = 36.6 bits (83), Expect = 0.15
Identities = 29/113 (25%), Positives = 50/113 (44%), Gaps = 4/113 (3%)
Query: 444 LSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGA 503
+ S L+SW ++ N N I+S + + Q + Q ++ +S + ++ NL PG
Sbjct: 67 VGSAGILLSW-NTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGT 125
Query: 504 QYQVVIYLRKGPLIGPPSDPVTFAI---VPTGIKDLMLYPLGPTAVVLSWTRP 553
Y++ + IG SDP F P + +L + +AV L W P
Sbjct: 126 TYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP 178
Score = 36.6 bits (83), Expect = 0.15
Identities = 83/418 (19%), Positives = 153/418 (36%), Gaps = 40/418 (9%)
Query: 343 VQMILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFS 402
V + L+W PP P ++ + + + V E + E +++L +Y VT +
Sbjct: 869 VTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLE-LSDLDYNVEYSAYVTAST 927
Query: 403 SSGSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQE---- 458
G +TR + + + +P G ++ P+ V LSS++ ++ WT +
Sbjct: 928 RFGDGKTRSN-----IISFQTPEGA----PSDPPKDVYYANLSSSSIILFWTPPSKPNGI 978
Query: 459 -NYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLI 517
Y S S T + + + S+ II+ L + Y +
Sbjct: 979 IQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVST--IIDKLTIFSYYTFWLTASTSVGN 1036
Query: 518 GPPSDPV----TFAIVPTGIKDLMLYP-LGPTAVVLSWTRPYL--GVFRKYVVEMFYFNP 570
G S + T +P G + Y + TA+ +SW P G+ YV + P
Sbjct: 1037 GNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTP 1096
Query: 571 ATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFIT 630
+ TY S+ NL Y ++T T + S ++ + T
Sbjct: 1097 RHVRPPLVTYER---------SIYFDNLEKYTDYILKITPST--EKGFSDTYTAQLYIKT 1145
Query: 631 APVAPEITSV-EYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTA 689
PE + + F +L S D + ++ + + +G + +T +
Sbjct: 1146 EEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYII 1205
Query: 690 ILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEP----APPKSLFAVNKTQTSVTLLW 743
+ L P +Y+ A T +G S + + APP++L +N T V L W
Sbjct: 1206 LEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKW 1263
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 284 bits (727), Expect = 3e-76
Identities = 235/776 (30%), Positives = 379/776 (48%), Gaps = 109/776 (14%)
Query: 435 KPQHVS-VHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSK 493
+P +VS + V ++TTA T S +N++ + ++ + Q T + +
Sbjct: 625 RPSNVSNIDVSTNTTAA---TLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITD 681
Query: 494 PIIENLVPGAQYQVVIYLRKGPLI-----GPPS---DPVTFAIVPTGIKDLMLYPLGPTA 545
+ L+PG+ Y V I+ + G I G S DP + A D + P P A
Sbjct: 682 ATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPASMASF-----DCEVVPKEP-A 735
Query: 546 VVLSWTRPYLGVFRKYVVEMFY--FNPAT----MTSEWTTYYEIAAT-VSLTASVRIANL 598
+VL WT P G + +E+ +N AT +SE T Y T ++ + S
Sbjct: 736 LVLKWTCPP-GANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTS------ 788
Query: 599 LPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPV---APEITSVEYFNSLLYISWTYGD 655
YN +T V+ G ++ T P +P ITSV + + + S
Sbjct: 789 -----YNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGF--- 840
Query: 656 DTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSM 715
+ SH + + V+ + T P D+ + + S+T +
Sbjct: 841 ---EASHGPIKAYAVI--------------LTTGEAGHPSADVLKYTYEDFKKGASDTYV 883
Query: 716 LRLVKLEP-APPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVS 774
L++ E +SL V K + V E ++ + +GS + + ++
Sbjct: 884 TYLIRTEEKGRSQSLSEVLKYEIDVGN---ESTTLGYYNGKLEPLGS-YRACVAGFTNIT 939
Query: 775 SHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLI 834
H + A +Y SFS S +V +P V+ +V + L+
Sbjct: 940 FHPQNKGLIDGAESY----VSFSRYSDAVSL---------PQDPGVICGAVFGCIFGALV 986
Query: 835 GLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDD 894
+ + I RKK R+ V+F+ ++ KK KL +++++
Sbjct: 987 IVTVGGFIFWRKK-----RKDAKNNEVSFSQIKP-------------KKSKL---IRVEN 1025
Query: 895 FDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLV 954
F+AY K DS+ F+ ++E+LKL+G+ P +AA+L NR KNRY N+LPYD SRV+L
Sbjct: 1026 FEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKL- 1084
Query: 955 SMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 1014
S+ DYINANY+PGY+S +++IATQGPLP T DFW+MV ++ I+MLT+C E+
Sbjct: 1085 SVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQ 1144
Query: 1015 RRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRIN--YADEMQDVMHFNYTAW 1072
R KC+ YWP +++ YGDITV M SE +W R F + E + F++T+W
Sbjct: 1145 GRTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSW 1203
Query: 1073 PDHGVPTANAAESILQFVHMVRQQATKS--KGPMIIHCSAGVGRTGTFIALDRLLQHIRD 1130
PDHGVP + + ++ F ++VR +S + P+++HCSAGVGRTGTFIA+DRL+ I +
Sbjct: 1204 PDHGVP--DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIEN 1261
Query: 1131 HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENVS 1186
VD+ G+V ++R +R MVQTE+QY+F++QCV + + + Q+ D+IY+N +
Sbjct: 1262 ENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCV--LDIVRSQKDSKVDLIYQNTT 1315
Score = 36.6 bits (83), Expect = 0.15
Identities = 91/410 (22%), Positives = 158/410 (38%), Gaps = 68/410 (16%)
Query: 441 VHVLSSTTALMSWTSSQ-ENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENL 499
V V+S+T ++W+S E++ I Q+ + R+E + II L
Sbjct: 462 VTVVSTTEIGLAWSSHDAESFQMHIT-------QEGAGNSRVEI-----TTNQSIIIGGL 509
Query: 500 VPGAQYQVVIYLRKGPL-IGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVF 558
PG +Y I + KGP S V VP+ + D+ + + T + L W P
Sbjct: 510 FPGTKYCFEI-VPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSP--DGA 566
Query: 559 RKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVT---WGD 615
+YV + + S T+ Y+ A T+ L+P YN ++ WGD
Sbjct: 567 SEYVYHLVI--ESKHGSNHTSTYDKAITLQ--------GLIPGTLYNITISPEVDHVWGD 616
Query: 616 PELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGK 675
P +ST + T P V + +SW DD + ++S L ++ G
Sbjct: 617 P------NSTAQY-TRPSNVSNIDVSTNTTAATLSWQNFDDASP-TYSYCL--LIEKAGN 666
Query: 676 KKIKKSVTRNVM---TAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPA------PP 726
V ++ + L PG Y + + A G + LEP P
Sbjct: 667 SSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDG-------IKSLEPGRKSFCTDP 719
Query: 727 KSLFA----VNKTQTSVTLLWV-EEGVADFFEVFCQQVGSSQKTKLQEPVAVSS--HVVT 779
S+ + V + ++ L W G FE+ + T L+ + + +
Sbjct: 720 ASMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTE 779
Query: 780 ISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEM-----NPNVVVIS 824
++ L +T+YN S+T+ S + PT +T +T+ +PN+ +S
Sbjct: 780 VTYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVS 829
Score = 35.8 bits (81), Expect = 0.25
Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 18/160 (11%)
Query: 683 TRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRL-VKLEPAPPKSLFAVNKTQTSVTL 741
+R+ ++ L PG YN +V + G+ + + + AVN + TS+TL
Sbjct: 325 SRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTL 384
Query: 742 LWV---EEGVADF-FEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797
+W E +++ +++ S + EP AV I L +T YN +V
Sbjct: 385 IWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAV------IPGLRSSTFYNITVCPVL 438
Query: 798 HDSPSVPTFIAVSTMVTEMNPNVVVISV-LAILSTLLIGL 836
D P F+ V T P V V + ++ST IGL
Sbjct: 439 GDIEGTPGFLQVHT------PPVPVSDFRVTVVSTTEIGL 472
Score = 34.3 bits (77), Expect = 0.73
Identities = 69/291 (23%), Positives = 103/291 (35%), Gaps = 49/291 (16%)
Query: 530 PTGIKDLMLYPLGPTAVVLSW-TRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVS 588
P+ + D+ + PT V+L+W + KYVV+ N T+ TV
Sbjct: 119 PSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENEKTI------------TVV 166
Query: 589 LTASVRIANLLPAWYYNFRVT----MVTWGDPELSCCDSSTISFITAPVAPEITSVEYFN 644
I L PA Y F +T TWGDP + I IT P+ V
Sbjct: 167 HQPWCNITGLRPATSYVFSITPGIGNETWGDPRV-------IKVITEPIPVSDLRVALTG 219
Query: 645 -SLLYISWTYGDDTTDL--------SHSRMLHWMVVAEGKKKIKKSVTRNVMTAIL--SL 693
+SW+ G+ T SH + + +K V N+ +L +
Sbjct: 220 VRKAALSWSNGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNK 279
Query: 694 PPGDI------YNLSVTACTERGSNTSMLRLVKL-EPAPPKSLFAVNKTQTSVTLLWVEE 746
GD + S T + GS T+ + L P P S T V L+ +E
Sbjct: 280 TKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPSS--GQQSRDTEVLLVGLEP 337
Query: 747 GVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFS 797
G V+ Q ++ +P A+ I + TA N S TS +
Sbjct: 338 GTRYNATVYSQAANGTE----GQPQAIEFRTNAI-QVFDVTAVNISATSLT 383
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform 2
precursor [Homo sapiens]
Length = 937
Score = 279 bits (714), Expect = 1e-74
Identities = 214/715 (29%), Positives = 332/715 (46%), Gaps = 86/715 (12%)
Query: 497 ENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLG 556
E L PG Y ++ K G + V+ + VP + L + + L WT P
Sbjct: 265 ERLEPGTLYTFSVWAEKNGARGSRQN-VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGP 323
Query: 557 VFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTAS-----VRIANLLPAWYYNFRVTMV 611
Y S W ++ T T S + + L Y+ V
Sbjct: 324 GQSSY-------------SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTV--- 367
Query: 612 TWGDPELSCCDSSTISFITAPVAPEITSVE---YFNSLLYISWTYGDDTTDLSHSRMLHW 668
W + +ST++ TAP E+T ++ + + + W D + + W
Sbjct: 368 -WAERNEVRGYNSTLTAATAP--NEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 424
Query: 669 MVVAEGKKKI--------KKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK 720
++ + S T + +L PG +YN +V A ER S + +
Sbjct: 425 ASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWA--ERNDVASSTQSL- 481
Query: 721 LEPAPPKSLFAVNKTQTS----VTLLW-VEEGVADFFEVFCQ-QVGSSQKTKLQEPVAVS 774
P ++ + TS V L+W +G + FE+ Q GS ++ E V+V
Sbjct: 482 CASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVL 541
Query: 775 SHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLI 834
L PA +Y ++T+ D V ++ S + + V+ + + IL L++
Sbjct: 542 G-------LGPARSYPATITTI-WDGMKV---VSHSVVCHTESAGVIAGAFVGILLFLIL 590
Query: 835 GLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDD 894
LL+ + R K Q E F + G +P +D
Sbjct: 591 VGLLIFFLKRRNKKKQQKPELRDLVFSS------PGDIP------------------AED 626
Query: 895 FDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLV 954
F +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+SRV L
Sbjct: 627 FADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLK 686
Query: 955 SMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 1014
++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT C E
Sbjct: 687 PIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEA 746
Query: 1015 RRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHFNYTAW 1072
RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F+Y AW
Sbjct: 747 GRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAW 806
Query: 1073 PDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD 1130
PDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL+ ++
Sbjct: 807 PDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS 864
Query: 1131 HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 1185
+ V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 865 EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 919
Score = 35.4 bits (80), Expect = 0.33
Identities = 44/205 (21%), Positives = 83/205 (40%), Gaps = 17/205 (8%)
Query: 623 SSTISFITAPVAPE----ITSVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKI 678
+S++ +T AP +T NS + ++W D + + + + +G +
Sbjct: 107 NSSVGTVTTATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEY--TGDGGRAG 164
Query: 679 KKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTS 738
+S +T + L PG +Y SV +++ R P P ++L +T +S
Sbjct: 165 TRSTAHTNIT-VDRLEPGCLYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSS 223
Query: 739 VTLLW-VEEG-VADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSF 796
+ L W V +G + + + G T+ + S VT L P T Y SV +
Sbjct: 224 IALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTS---VTAERLEPGTLYTFSVWAE 280
Query: 797 SHDSPSVPTFIAVSTMVTEMNPNVV 821
+ + +++ST+ PN V
Sbjct: 281 KNGARGSRQNVSISTV-----PNAV 300
Score = 32.0 bits (71), Expect = 3.6
Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 723 PAPPKSLFAVNKTQTSVTLLW-VEEGV-ADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
P P ++L +T +S++L W V +G+ + + Q G T+ + A + VT+
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN---VTV 86
Query: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNP 818
L P + Y CSV + V + + T T NP
Sbjct: 87 DGLGPGSLYTCSVWV---EKDGVNSSVGTVTTATAPNP 121
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform 1
precursor [Homo sapiens]
Length = 1115
Score = 279 bits (714), Expect = 1e-74
Identities = 214/715 (29%), Positives = 332/715 (46%), Gaps = 86/715 (12%)
Query: 497 ENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPTAVVLSWTRPYLG 556
E L PG Y ++ K G + V+ + VP + L + + L WT P
Sbjct: 443 ERLEPGTLYTFSVWAEKNGARGSRQN-VSISTVPNAVTSLSKQDWTNSTIALRWTAPQGP 501
Query: 557 VFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTAS-----VRIANLLPAWYYNFRVTMV 611
Y S W ++ T T S + + L Y+ V
Sbjct: 502 GQSSY-------------SYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYHLTV--- 545
Query: 612 TWGDPELSCCDSSTISFITAPVAPEITSVE---YFNSLLYISWTYGDDTTDLSHSRMLHW 668
W + +ST++ TAP E+T ++ + + + W D + + W
Sbjct: 546 -WAERNEVRGYNSTLTAATAP--NEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWVQW 602
Query: 669 MVVAEGKKKI--------KKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK 720
++ + S T + +L PG +YN +V A ER S + +
Sbjct: 603 ASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWA--ERNDVASSTQSL- 659
Query: 721 LEPAPPKSLFAVNKTQTS----VTLLW-VEEGVADFFEVFCQ-QVGSSQKTKLQEPVAVS 774
P ++ + TS V L+W +G + FE+ Q GS ++ E V+V
Sbjct: 660 CASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVL 719
Query: 775 SHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLI 834
L PA +Y ++T+ D V ++ S + + V+ + + IL L++
Sbjct: 720 G-------LGPARSYPATITTI-WDGMKV---VSHSVVCHTESAGVIAGAFVGILLFLIL 768
Query: 835 GLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDD 894
LL+ + R K Q E F + G +P +D
Sbjct: 769 VGLLIFFLKRRNKKKQQKPELRDLVFSS------PGDIP------------------AED 804
Query: 895 FDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLV 954
F +++ +DS+ F+ ++++L L+G A N KNRY N+LPYD+SRV L
Sbjct: 805 FADHVRKNERDSNCGFADKYQQLSLVGHSQSQMVASASENNAKNRYRNVLPYDWSRVPLK 864
Query: 955 SMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK 1014
++EE G+DYINA+++PG SPQE+IATQGPLP+T DFW++V +Q+S +VMLT C E
Sbjct: 865 PIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEA 924
Query: 1015 RRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQ--DVMHFNYTAW 1072
RVKC+HYWP +P +G + V ++ EE ++W R + +E + V F+Y AW
Sbjct: 925 GRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQFHYQAW 984
Query: 1073 PDHGVPTANAAESILQFVHMVRQ--QATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD 1130
PDHGVP ++ +++L F M+RQ T GP I+HCSAGVGRTGT IALD LL+ ++
Sbjct: 985 PDHGVP--SSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS 1042
Query: 1131 HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFCISDVIYENV 1185
+ V +MR R MVQTE QY+F+HQC+ + Q +V YE+V
Sbjct: 1043 EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQQSAQAPAEKEVPYEDV 1097
Score = 37.4 bits (85), Expect = 0.086
Identities = 50/229 (21%), Positives = 91/229 (39%), Gaps = 25/229 (10%)
Query: 607 RVTMVTWGDPELSCCD--------SSTISFITAPVAPE----ITSVEYFNSLLYISWTYG 654
RVT+ G L C +S++ +T+ AP +T NS + ++W
Sbjct: 261 RVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPVRNLTVEAQTNSSIALTWEVP 320
Query: 655 DDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTS 714
D + + + + +G + +S +T + L PG +Y SV +++
Sbjct: 321 DGPDPQNSTYGVEY--TGDGGRAGTRSTAHTNIT-VDRLEPGCLYVFSVWVGKNGINSSR 377
Query: 715 MLRLVKLEPAPPKSLFAVNKTQTSVTLLW-VEEG-VADFFEVFCQQVGSSQKTKLQEPVA 772
R P P ++L +T +S+ L W V +G + + + G T+ +
Sbjct: 378 ETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTN 437
Query: 773 VSSHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVV 821
S VT L P T Y SV + + + +++ST+ PN V
Sbjct: 438 TS---VTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTV-----PNAV 478
Score = 32.0 bits (71), Expect = 3.6
Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 8/98 (8%)
Query: 723 PAPPKSLFAVNKTQTSVTLLW-VEEGV-ADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI 780
P P ++L +T +S++L W V +G+ + + Q G T+ + A + VT+
Sbjct: 30 PNPGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATN---VTV 86
Query: 781 SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNP 818
L P + Y CSV + V + + T T NP
Sbjct: 87 DGLGPGSLYTCSVWV---EKDGVNSSVGTVTTATAPNP 121
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 228 bits (580), Expect = 3e-59
Identities = 129/344 (37%), Positives = 193/344 (56%), Gaps = 14/344 (4%)
Query: 828 ILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPY-----NWSKNGLK 882
+L+ +LI L+++ +++ ++K + SL P N+ G++
Sbjct: 1268 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1327
Query: 883 KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 942
P+ + D I+ + + KFS ++E + G ++L +N+ KNRY N
Sbjct: 1328 DHP---PIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYAN 1383
Query: 943 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 1002
++ YD SRV L S++ G+DYINANYI GY YIATQGPLPET DFW+MV +Q++
Sbjct: 1384 VIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRT 1443
Query: 1003 QIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADE 1060
+VM+T+ EK RVKCD YWP G I V ++ E + R F ++ + E
Sbjct: 1444 ATVVMMTRLEEKSRVKCDQYWP-ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSE 1502
Query: 1061 MQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIA 1120
+++ F + AWPDHGVP IL F+ V+ GPM++HCSAGVGRTG FI
Sbjct: 1503 KRELRQFQFMAWPDHGVP--EYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1560
Query: 1121 LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
+D +L+ ++ + VDI G V+ MRS R MVQTE+QY+FIH+ +
Sbjct: 1561 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1604
Score = 188 bits (477), Expect = 3e-47
Identities = 103/251 (41%), Positives = 145/251 (57%), Gaps = 13/251 (5%)
Query: 916 ELKLIGLDIPH----FAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIP 971
E KL+ H +A+LP N+ KNR NI+PY+ +RV L + EG+DYINA+++
Sbjct: 1642 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLD 1701
Query: 972 GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIA 1031
GY + YIATQGPL E+ DFW+M+ + S IIVMLT+ E R KC YWP E
Sbjct: 1702 GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSAR 1760
Query: 1032 YGDITVEMISEEEQDDWACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF 1089
Y V+ ++E + R F++ A + Q + F +T WP+ GVP E + F
Sbjct: 1761 YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDF 1818
Query: 1090 ---VHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSY 1146
VH ++Q + GP+ +HCSAGVGRTG FI L +L+ +R VD+ V +R+
Sbjct: 1819 IGQVHKTKEQFGQD-GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQ 1877
Query: 1147 RMSMVQTEEQY 1157
R +MVQTE+QY
Sbjct: 1878 RPAMVQTEDQY 1888
Score = 32.0 bits (71), Expect = 3.6
Identities = 71/331 (21%), Positives = 130/331 (39%), Gaps = 32/331 (9%)
Query: 429 IEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQ 488
++ L + P + V ++T+ ++W S NS V+ + Q + Q
Sbjct: 315 VKALPKPPIDLVVTETTATSVTLTWDSG----NSEPVTYYGI--QYRAAGTEGPFQEVDG 368
Query: 489 VNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPV---TFAIVPTGI-KDLMLYPLGPT 544
V +++ I L P ++Y + GPPS+ V T P+ + + L +
Sbjct: 369 VATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSAS 428
Query: 545 AVVLSWTRPYL--GVFRKYVVEMFYFNPATMT--SEWTTYYEIAATVSLTASVRIANLLP 600
+++ W P G+ R Y V Y+ P + + W + A ++ S LLP
Sbjct: 429 TMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNAWHKHNTDAGLLTTVGS-----LLP 480
Query: 601 AWYYNFRVTMVTW-GD-PELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTT 658
Y+ RV T GD P T + A A VE ++ + +SW
Sbjct: 481 GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVES-DTRIQLSWLLPPQER 539
Query: 659 DLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERG----SNTS 714
+ + +++W E ++ K + + L P +Y + A ++ G + T
Sbjct: 540 IIMYE-LVYWAAEDEDQQH-KVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTI 597
Query: 715 MLRLVKLEP-APPKSLFAVNKTQTSVTLLWV 744
R + P APP+ + V+ T+V + WV
Sbjct: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Score = 30.8 bits (68), Expect = 8.0
Identities = 43/172 (25%), Positives = 64/172 (37%), Gaps = 9/172 (5%)
Query: 668 WMVVAEG-KKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRL-VKLEPAP 725
WM+ AE K+ + V RNV+ + N + A + G + ++ VK P P
Sbjct: 265 WMMGAEELTKEDEMPVGRNVLELSNVVRSA---NYTCVAISSLGMIEATAQVTVKALPKP 321
Query: 726 PKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLP 785
P L T TSVTL W Q + + QE V++ +I L P
Sbjct: 322 PIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSP 381
Query: 786 ATAYN---CSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLI 834
+ Y +V S PS P V +L+ ST+L+
Sbjct: 382 FSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLS-ASTMLV 432
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 228 bits (580), Expect = 3e-59
Identities = 129/344 (37%), Positives = 193/344 (56%), Gaps = 14/344 (4%)
Query: 828 ILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPY-----NWSKNGLK 882
+L+ +LI L+++ +++ ++K + SL P N+ G++
Sbjct: 1259 VLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMR 1318
Query: 883 KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 942
P+ + D I+ + + KFS ++E + G ++L +N+ KNRY N
Sbjct: 1319 DHP---PIPITDLADNIERLKANDGLKFSQEYESIDP-GQQFTWENSNLEVNKPKNRYAN 1374
Query: 943 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 1002
++ YD SRV L S++ G+DYINANYI GY YIATQGPLPET DFW+MV +Q++
Sbjct: 1375 VIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRT 1434
Query: 1003 QIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADE 1060
+VM+T+ EK RVKCD YWP G I V ++ E + R F ++ + E
Sbjct: 1435 ATVVMMTRLEEKSRVKCDQYWP-ARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSE 1493
Query: 1061 MQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIA 1120
+++ F + AWPDHGVP IL F+ V+ GPM++HCSAGVGRTG FI
Sbjct: 1494 KRELRQFQFMAWPDHGVP--EYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIV 1551
Query: 1121 LDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
+D +L+ ++ + VDI G V+ MRS R MVQTE+QY+FIH+ +
Sbjct: 1552 IDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1595
Score = 188 bits (477), Expect = 3e-47
Identities = 103/251 (41%), Positives = 145/251 (57%), Gaps = 13/251 (5%)
Query: 916 ELKLIGLDIPH----FAADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIP 971
E KL+ H +A+LP N+ KNR NI+PY+ +RV L + EG+DYINA+++
Sbjct: 1633 EFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLD 1692
Query: 972 GYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIA 1031
GY + YIATQGPL E+ DFW+M+ + S IIVMLT+ E R KC YWP E
Sbjct: 1693 GYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWP-AERSAR 1751
Query: 1032 YGDITVEMISEEEQDDWACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF 1089
Y V+ ++E + R F++ A + Q + F +T WP+ GVP E + F
Sbjct: 1752 YQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP--KTGEGFIDF 1809
Query: 1090 ---VHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSY 1146
VH ++Q + GP+ +HCSAGVGRTG FI L +L+ +R VD+ V +R+
Sbjct: 1810 IGQVHKTKEQFGQD-GPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQ 1868
Query: 1147 RMSMVQTEEQY 1157
R +MVQTE+QY
Sbjct: 1869 RPAMVQTEDQY 1879
Score = 32.0 bits (71), Expect = 3.6
Identities = 71/331 (21%), Positives = 130/331 (39%), Gaps = 32/331 (9%)
Query: 429 IEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQ 488
++ L + P + V ++T+ ++W S NS V+ + Q + Q
Sbjct: 315 VKALPKPPIDLVVTETTATSVTLTWDSG----NSEPVTYYGI--QYRAAGTEGPFQEVDG 368
Query: 489 VNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPV---TFAIVPTGI-KDLMLYPLGPT 544
V +++ I L P ++Y + GPPS+ V T P+ + + L +
Sbjct: 369 VATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSAS 428
Query: 545 AVVLSWTRPYL--GVFRKYVVEMFYFNPATMT--SEWTTYYEIAATVSLTASVRIANLLP 600
+++ W P G+ R Y V Y+ P + + W + A ++ S LLP
Sbjct: 429 TMLVQWEPPEEPNGLVRGYRV---YYTPDSRRPPNAWHKHNTDAGLLTTVGS-----LLP 480
Query: 601 AWYYNFRVTMVTW-GD-PELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTT 658
Y+ RV T GD P T + A A VE ++ + +SW
Sbjct: 481 GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVES-DTRIQLSWLLPPQER 539
Query: 659 DLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERG----SNTS 714
+ + +++W E ++ K + + L P +Y + A ++ G + T
Sbjct: 540 IIMYE-LVYWAAEDEDQQH-KVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTI 597
Query: 715 MLRLVKLEP-APPKSLFAVNKTQTSVTLLWV 744
R + P APP+ + V+ T+V + WV
Sbjct: 598 EARTAQSTPSAPPQKVMCVSMGSTTVRVSWV 628
Score = 30.8 bits (68), Expect = 8.0
Identities = 43/172 (25%), Positives = 64/172 (37%), Gaps = 9/172 (5%)
Query: 668 WMVVAEG-KKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRL-VKLEPAP 725
WM+ AE K+ + V RNV+ + N + A + G + ++ VK P P
Sbjct: 265 WMMGAEELTKEDEMPVGRNVLELSNVVRSA---NYTCVAISSLGMIEATAQVTVKALPKP 321
Query: 726 PKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLP 785
P L T TSVTL W Q + + QE V++ +I L P
Sbjct: 322 PIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSP 381
Query: 786 ATAYN---CSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLI 834
+ Y +V S PS P V +L+ ST+L+
Sbjct: 382 FSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLS-ASTMLV 432
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 225 bits (574), Expect = 2e-58
Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)
Query: 821 VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 880
VV VLA++ +I +++ L+ RK+ +R+ +S+ + ++P + +
Sbjct: 1270 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 1318
Query: 881 LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 931
++ R+L P+ + + +I+ + + + KFS ++E + G ++L
Sbjct: 1319 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 1377
Query: 932 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 991
+N+ KNRY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET
Sbjct: 1378 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1437
Query: 992 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 1051
DFW+M+ +Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R
Sbjct: 1438 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1496
Query: 1052 HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 1109
F + N + E ++V F +TAWPDHGVP L F+ V+ GPM++HCS
Sbjct: 1497 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1554
Query: 1110 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
AGVGRTG FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1555 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1609
Score = 191 bits (484), Expect = 5e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 928 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 987
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1663 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1722
Query: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1723 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1781
Query: 1048 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 1102
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1782 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1838
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1839 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1898
Score = 49.7 bits (117), Expect = 2e-05
Identities = 84/350 (24%), Positives = 148/350 (42%), Gaps = 34/350 (9%)
Query: 413 QSAKSLSFYISPSG--EWIEELTEK--PQHVSVHVLSSTTALMSWTSSQENYNSTIVSVV 468
QSA +S G E I ++T K P+ V++ +TA S T + ++ N VS
Sbjct: 296 QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT-SITLTWDSGNPEPVSYY 354
Query: 469 SLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPV---T 525
+ K K S+ L K+ V +++ + L P + Y+ + GPPS+PV T
Sbjct: 355 IIQ-HKPKNSEELYKEI-DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 412
Query: 526 FAIVPTGI-KDLMLYPLGPTAVVLSWTRPYL--GVFRKYVVEMFYFNPATMTSEWTTYYE 582
P+ +D+ L T +++ W P G + Y V + +P + W +
Sbjct: 413 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV-YYTMDPTQHVNNWMKH-- 469
Query: 583 IAATVSLTASVRIANLLPAWYYNFRVTMVTW-GDPELSCCDSSTISFITAPVAPEITSVE 641
V+ + I NL+P Y+ +V T GD LS D I+ P P E
Sbjct: 470 ---NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSS-DIQVITQTGVPGQPLNFKAE 525
Query: 642 -YFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTA--ILSLPPGDI 698
+ + +SWT T ++ +V +G+ ++ +T T+ + L P +
Sbjct: 526 PESETSILLSWTPPRSDTIANYE-----LVYKDGEHGEEQRITIEPGTSYRLQGLKPNSL 580
Query: 699 YNLSVTACTERGSNTSML----RLVKLEP-APPKSLFAVNKTQTSVTLLW 743
Y + A + +G S R ++ +P APP+ + + + TS+ + W
Sbjct: 581 YYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSW 630
Score = 39.7 bits (91), Expect = 0.017
Identities = 84/391 (21%), Positives = 153/391 (39%), Gaps = 58/391 (14%)
Query: 393 KYKLSVTTFSSSGSCETRKSQSAKSLSFYI---SPSGEWIEELTE-----KPQHVSVHVL 444
K+ ++ + ++ G+ +K+ S K L+F P I+ +T+ +P +
Sbjct: 468 KHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPE 527
Query: 445 SSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQ 504
S T+ L+SWT + + + V K+ + E+Q T + ++ L P +
Sbjct: 528 SETSILLSWTPPRSDTIANYELVY-------KDGEHGEEQRITIEPGTSYRLQGLKPNSL 580
Query: 505 YQVVIYLRKGPLIGPPSDPV---TFAIVPTGI-KDLMLYPLGPTAVVLSWTRPYL----G 556
Y + R +G + + T P+ +D+ T++++SW P + G
Sbjct: 581 YYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNG 640
Query: 557 VFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTW--- 613
+ +Y ++ + E +EI S T + L Y VT T
Sbjct: 641 IITEYSIKY-----TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGP 695
Query: 614 GDPELSCCDSSTISFITAPVAPEITSVEYFNSL-LYISWTYGDDTTDLSHSRM----LHW 668
G LS + + P P VE NS + +SW + H ++ +H+
Sbjct: 696 GPESLSVLIRTNEDVPSGP--PRKVEVEAVNSTSVKVSWR--SPVPNKQHGQIRGYQVHY 751
Query: 669 MVVAEGKKKIKKSVTRNVMTA---------------ILSLPPGDIYNLSVTACTERGSNT 713
+ + G+ K + + ++VM A I L P Y+L+VTA T +G
Sbjct: 752 VRMENGEPK-GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGA 810
Query: 714 -SMLRLVKLEPA-PPKSLFAVNKTQTSVTLL 742
S +LV A P K +N TQ + L+
Sbjct: 811 RSKPKLVSTTGAVPGKPRLVINHTQMNTALI 841
Score = 37.7 bits (86), Expect = 0.066
Identities = 91/483 (18%), Positives = 175/483 (36%), Gaps = 38/483 (7%)
Query: 345 MILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSS 404
++L+W PP+ T + ++ + E + + ++ + LK Y + S
Sbjct: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQ 591
Query: 405 GSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTI 464
G + SA+++ PS PQ +S SST+ L+SW + I
Sbjct: 592 GLGASTAEISARTMQS--KPSAP--------PQDISCTSPSSTSILVSWQPPPVEKQNGI 641
Query: 465 VSVVSLT-CQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDP 523
++ S+ E + + +++K ++E L +Y++ + GP S
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS 701
Query: 524 V---TFAIVPTG-IKDLMLYPLGPTAVVLSWTRP----YLGVFRKYVVEMFYFNPATMTS 575
V T VP+G + + + + T+V +SW P G R Y V
Sbjct: 702 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 761
Query: 576 EWTTYYEIAATV------SLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFI 629
+ + A + + I+ L P Y+ VT T +
Sbjct: 762 QPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 821
Query: 630 TAPVAPEITSVEYFNSLLYISWTYGDDT-TDLSHSRMLHWMVVAEGKKKIKKSVTRNVMT 688
P P + + I W DT L R+ E ++ S + T
Sbjct: 822 AVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 881
Query: 689 AILSLPPGDIYNLSVTACTERGSNTSMLRLVKL-EPAP---PKSLFAVNKTQTSVTLLW- 743
A + G Y ++A + G M++ + + E P P++L + T TSV L W
Sbjct: 882 A-TDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQ 940
Query: 744 -----VEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSH 798
G+ + + + + + +++ + + +T++ L P T Y+ V + +
Sbjct: 941 PPVLAERNGIITKYTLLYRDI-NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTS 999
Query: 799 DSP 801
P
Sbjct: 1000 KGP 1002
Score = 31.6 bits (70), Expect = 4.7
Identities = 26/118 (22%), Positives = 43/118 (36%), Gaps = 3/118 (2%)
Query: 719 VKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVV 778
VK P PP + T TS+TL W Q + + +E V++
Sbjct: 319 VKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRY 378
Query: 779 TISSLLPATAYN---CSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
+++ L P + Y +V + PS P S P V +L+ + L+
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 225 bits (574), Expect = 2e-58
Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)
Query: 821 VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 880
VV VLA++ +I +++ L+ RK+ +R+ +S+ + ++P + +
Sbjct: 1257 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 1305
Query: 881 LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 931
++ R+L P+ + + +I+ + + + KFS ++E + G ++L
Sbjct: 1306 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 1364
Query: 932 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 991
+N+ KNRY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET
Sbjct: 1365 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1424
Query: 992 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 1051
DFW+M+ +Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R
Sbjct: 1425 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1483
Query: 1052 HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 1109
F + N + E ++V F +TAWPDHGVP L F+ V+ GPM++HCS
Sbjct: 1484 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1541
Query: 1110 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
AGVGRTG FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1542 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1596
Score = 191 bits (484), Expect = 5e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 928 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 987
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1650 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1709
Query: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1710 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1768
Query: 1048 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 1102
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1769 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1825
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1826 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1885
Score = 49.7 bits (117), Expect = 2e-05
Identities = 84/350 (24%), Positives = 148/350 (42%), Gaps = 34/350 (9%)
Query: 413 QSAKSLSFYISPSG--EWIEELTEK--PQHVSVHVLSSTTALMSWTSSQENYNSTIVSVV 468
QSA +S G E I ++T K P+ V++ +TA S T + ++ N VS
Sbjct: 283 QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT-SITLTWDSGNPEPVSYY 341
Query: 469 SLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPV---T 525
+ K K S+ L K+ V +++ + L P + Y+ + GPPS+PV T
Sbjct: 342 IIQ-HKPKNSEELYKEI-DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 399
Query: 526 FAIVPTGI-KDLMLYPLGPTAVVLSWTRPYL--GVFRKYVVEMFYFNPATMTSEWTTYYE 582
P+ +D+ L T +++ W P G + Y V + +P + W +
Sbjct: 400 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV-YYTMDPTQHVNNWMKH-- 456
Query: 583 IAATVSLTASVRIANLLPAWYYNFRVTMVTW-GDPELSCCDSSTISFITAPVAPEITSVE 641
V+ + I NL+P Y+ +V T GD LS D I+ P P E
Sbjct: 457 ---NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSS-DIQVITQTGVPGQPLNFKAE 512
Query: 642 -YFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTA--ILSLPPGDI 698
+ + +SWT T ++ +V +G+ ++ +T T+ + L P +
Sbjct: 513 PESETSILLSWTPPRSDTIANYE-----LVYKDGEHGEEQRITIEPGTSYRLQGLKPNSL 567
Query: 699 YNLSVTACTERGSNTSML----RLVKLEP-APPKSLFAVNKTQTSVTLLW 743
Y + A + +G S R ++ +P APP+ + + + TS+ + W
Sbjct: 568 YYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSW 617
Score = 39.7 bits (91), Expect = 0.017
Identities = 84/391 (21%), Positives = 153/391 (39%), Gaps = 58/391 (14%)
Query: 393 KYKLSVTTFSSSGSCETRKSQSAKSLSFYI---SPSGEWIEELTE-----KPQHVSVHVL 444
K+ ++ + ++ G+ +K+ S K L+F P I+ +T+ +P +
Sbjct: 455 KHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPE 514
Query: 445 SSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQ 504
S T+ L+SWT + + + V K+ + E+Q T + ++ L P +
Sbjct: 515 SETSILLSWTPPRSDTIANYELVY-------KDGEHGEEQRITIEPGTSYRLQGLKPNSL 567
Query: 505 YQVVIYLRKGPLIGPPSDPV---TFAIVPTGI-KDLMLYPLGPTAVVLSWTRPYL----G 556
Y + R +G + + T P+ +D+ T++++SW P + G
Sbjct: 568 YYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNG 627
Query: 557 VFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTW--- 613
+ +Y ++ + E +EI S T + L Y VT T
Sbjct: 628 IITEYSIKY-----TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGP 682
Query: 614 GDPELSCCDSSTISFITAPVAPEITSVEYFNSL-LYISWTYGDDTTDLSHSRM----LHW 668
G LS + + P P VE NS + +SW + H ++ +H+
Sbjct: 683 GPESLSVLIRTNEDVPSGP--PRKVEVEAVNSTSVKVSWR--SPVPNKQHGQIRGYQVHY 738
Query: 669 MVVAEGKKKIKKSVTRNVMTA---------------ILSLPPGDIYNLSVTACTERGSNT 713
+ + G+ K + + ++VM A I L P Y+L+VTA T +G
Sbjct: 739 VRMENGEPK-GQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGA 797
Query: 714 -SMLRLVKLEPA-PPKSLFAVNKTQTSVTLL 742
S +LV A P K +N TQ + L+
Sbjct: 798 RSKPKLVSTTGAVPGKPRLVINHTQMNTALI 828
Score = 37.7 bits (86), Expect = 0.066
Identities = 91/483 (18%), Positives = 175/483 (36%), Gaps = 38/483 (7%)
Query: 345 MILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSS 404
++L+W PP+ T + ++ + E + + ++ + LK Y + S
Sbjct: 519 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQ 578
Query: 405 GSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTI 464
G + SA+++ PS PQ +S SST+ L+SW + I
Sbjct: 579 GLGASTAEISARTMQS--KPSAP--------PQDISCTSPSSTSILVSWQPPPVEKQNGI 628
Query: 465 VSVVSLT-CQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDP 523
++ S+ E + + +++K ++E L +Y++ + GP S
Sbjct: 629 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS 688
Query: 524 V---TFAIVPTG-IKDLMLYPLGPTAVVLSWTRP----YLGVFRKYVVEMFYFNPATMTS 575
V T VP+G + + + + T+V +SW P G R Y V
Sbjct: 689 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 748
Query: 576 EWTTYYEIAATV------SLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFI 629
+ + A + + I+ L P Y+ VT T +
Sbjct: 749 QPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 808
Query: 630 TAPVAPEITSVEYFNSLLYISWTYGDDT-TDLSHSRMLHWMVVAEGKKKIKKSVTRNVMT 688
P P + + I W DT L R+ E ++ S + T
Sbjct: 809 AVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFT 868
Query: 689 AILSLPPGDIYNLSVTACTERGSNTSMLRLVKL-EPAP---PKSLFAVNKTQTSVTLLW- 743
A + G Y ++A + G M++ + + E P P++L + T TSV L W
Sbjct: 869 A-TDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQ 927
Query: 744 -----VEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSH 798
G+ + + + + + +++ + + +T++ L P T Y+ V + +
Sbjct: 928 PPVLAERNGIITKYTLLYRDI-NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTS 986
Query: 799 DSP 801
P
Sbjct: 987 KGP 989
Score = 31.6 bits (70), Expect = 4.7
Identities = 26/118 (22%), Positives = 43/118 (36%), Gaps = 3/118 (2%)
Query: 719 VKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVV 778
VK P PP + T TS+TL W Q + + +E V++
Sbjct: 306 VKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRY 365
Query: 779 TISSLLPATAYN---CSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
+++ L P + Y +V + PS P S P V +L+ + L+
Sbjct: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 423
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 225 bits (574), Expect = 2e-58
Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)
Query: 821 VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 880
VV VLA++ +I +++ L+ RK+ +R+ +S+ + ++P + +
Sbjct: 1261 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 1309
Query: 881 LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 931
++ R+L P+ + + +I+ + + + KFS ++E + G ++L
Sbjct: 1310 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 1368
Query: 932 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 991
+N+ KNRY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET
Sbjct: 1369 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1428
Query: 992 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 1051
DFW+M+ +Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R
Sbjct: 1429 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1487
Query: 1052 HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 1109
F + N + E ++V F +TAWPDHGVP L F+ V+ GPM++HCS
Sbjct: 1488 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1545
Query: 1110 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
AGVGRTG FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1546 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1600
Score = 191 bits (484), Expect = 5e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 928 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 987
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1654 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1713
Query: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1714 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1772
Query: 1048 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 1102
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1773 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1829
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1830 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1889
Score = 49.7 bits (117), Expect = 2e-05
Identities = 84/350 (24%), Positives = 148/350 (42%), Gaps = 34/350 (9%)
Query: 413 QSAKSLSFYISPSG--EWIEELTEK--PQHVSVHVLSSTTALMSWTSSQENYNSTIVSVV 468
QSA +S G E I ++T K P+ V++ +TA S T + ++ N VS
Sbjct: 296 QSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTAT-SITLTWDSGNPEPVSYY 354
Query: 469 SLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPV---T 525
+ K K S+ L K+ V +++ + L P + Y+ + GPPS+PV T
Sbjct: 355 IIQ-HKPKNSEELYKEI-DGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQT 412
Query: 526 FAIVPTGI-KDLMLYPLGPTAVVLSWTRPYL--GVFRKYVVEMFYFNPATMTSEWTTYYE 582
P+ +D+ L T +++ W P G + Y V + +P + W +
Sbjct: 413 SEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRV-YYTMDPTQHVNNWMKH-- 469
Query: 583 IAATVSLTASVRIANLLPAWYYNFRVTMVTW-GDPELSCCDSSTISFITAPVAPEITSVE 641
V+ + I NL+P Y+ +V T GD LS D I+ P P E
Sbjct: 470 ---NVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSS-DIQVITQTGVPGQPLNFKAE 525
Query: 642 -YFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTA--ILSLPPGDI 698
+ + +SWT T ++ +V +G+ ++ +T T+ + L P +
Sbjct: 526 PESETSILLSWTPPRSDTIANYE-----LVYKDGEHGEEQRITIEPGTSYRLQGLKPNSL 580
Query: 699 YNLSVTACTERGSNTSML----RLVKLEP-APPKSLFAVNKTQTSVTLLW 743
Y + A + +G S R ++ +P APP+ + + + TS+ + W
Sbjct: 581 YYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSW 630
Score = 43.1 bits (100), Expect = 0.002
Identities = 84/382 (21%), Positives = 153/382 (40%), Gaps = 49/382 (12%)
Query: 393 KYKLSVTTFSSSGSCETRKSQSAKSLSFYI---SPSGEWIEELTE-----KPQHVSVHVL 444
K+ ++ + ++ G+ +K+ S K L+F P I+ +T+ +P +
Sbjct: 468 KHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPE 527
Query: 445 SSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQ 504
S T+ L+SWT + + + V K+ + E+Q T + ++ L P +
Sbjct: 528 SETSILLSWTPPRSDTIANYELVY-------KDGEHGEEQRITIEPGTSYRLQGLKPNSL 580
Query: 505 YQVVIYLRKGPLIGPPSDPV---TFAIVPTGI-KDLMLYPLGPTAVVLSWTRPYL----G 556
Y + R +G + + T P+ +D+ T++++SW P + G
Sbjct: 581 YYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNG 640
Query: 557 VFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTW--- 613
+ +Y ++ + E +EI S T + L Y VT T
Sbjct: 641 IITEYSIKY-----TAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGP 695
Query: 614 GDPELSCCDSSTISFITAPVAPEITSVEYFNSL-LYISWTYGDDTTDLSHSRM----LHW 668
G LS + + P P VE NS + +SW + H ++ +H+
Sbjct: 696 GPESLSVLIRTNEDVPSGP--PRKVEVEAVNSTSVKVSWR--SPVPNKQHGQIRGYQVHY 751
Query: 669 MVVAEGKKKIKKSVTRNVMTA------ILSLPPGDIYNLSVTACTERGSNT-SMLRLVKL 721
+ + G+ K + + ++VM A I L P Y+L+VTA T +G S +LV
Sbjct: 752 VRMENGEPK-GQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVST 810
Query: 722 EPA-PPKSLFAVNKTQTSVTLL 742
A P K +N TQ + L+
Sbjct: 811 TGAVPGKPRLVINHTQMNTALI 832
Score = 40.0 bits (92), Expect = 0.013
Identities = 91/477 (19%), Positives = 174/477 (36%), Gaps = 35/477 (7%)
Query: 345 MILTWLPPKPPTAFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSS 404
++L+W PP+ T + ++ + E + + ++ + LK Y + S
Sbjct: 532 ILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQ 591
Query: 405 GSCETRKSQSAKSLSFYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTI 464
G + SA+++ PS PQ +S SST+ L+SW + I
Sbjct: 592 GLGASTAEISARTMQS--KPSAP--------PQDISCTSPSSTSILVSWQPPPVEKQNGI 641
Query: 465 VSVVSLT-CQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDP 523
++ S+ E + + +++K ++E L +Y++ + GP S
Sbjct: 642 ITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLS 701
Query: 524 V---TFAIVPTG-IKDLMLYPLGPTAVVLSWTRP----YLGVFRKYVVEMFYFNPATMTS 575
V T VP+G + + + + T+V +SW P G R Y V
Sbjct: 702 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 761
Query: 576 EWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAP 635
+ + A + I+ L P Y+ VT T + P P
Sbjct: 762 QPMLKDVMLADAQ---DMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKP 818
Query: 636 EITSVEYFNSLLYISWTYGDDT-TDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLP 694
+ + I W DT L R+ E ++ S + TA +
Sbjct: 819 RLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTA-TDIH 877
Query: 695 PGDIYNLSVTACTERGSNTSMLRLVKL-EPAP---PKSLFAVNKTQTSVTLLW------V 744
G Y ++A + G M++ + + E P P++L + T TSV L W
Sbjct: 878 KGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAE 937
Query: 745 EEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNCSVTSFSHDSP 801
G+ + + + + + +++ + + +T++ L P T Y+ V + + P
Sbjct: 938 RNGIITKYTLLYRDI-NIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKGP 993
Score = 31.6 bits (70), Expect = 4.7
Identities = 26/118 (22%), Positives = 43/118 (36%), Gaps = 3/118 (2%)
Query: 719 VKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVV 778
VK P PP + T TS+TL W Q + + +E V++
Sbjct: 319 VKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRY 378
Query: 779 TISSLLPATAYN---CSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
+++ L P + Y +V + PS P S P V +L+ + L+
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 225 bits (574), Expect = 2e-58
Identities = 130/355 (36%), Positives = 203/355 (57%), Gaps = 26/355 (7%)
Query: 821 VVISVLAILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNG 880
VV VLA++ +I +++ L+ RK+ +R+ +S+ + ++P + +
Sbjct: 859 VVGPVLAVV--FIICIVIAILLYKRKRAESDSRK---------SSIPNNKEIPSHHPTDP 907
Query: 881 LKKRKLT---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADL 931
++ R+L P+ + + +I+ + + + KFS ++E + G ++L
Sbjct: 908 VELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNL 966
Query: 932 PLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRN 991
+N+ KNRY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET
Sbjct: 967 EVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFG 1026
Query: 992 DFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACR 1051
DFW+M+ +Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R
Sbjct: 1027 DFWRMIWEQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVR 1085
Query: 1052 HFRI--NYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCS 1109
F + N + E ++V F +TAWPDHGVP L F+ V+ GPM++HCS
Sbjct: 1086 TFALYKNGSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCS 1143
Query: 1110 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
AGVGRTG FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1144 AGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1198
Score = 191 bits (484), Expect = 5e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 928 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 987
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311
Query: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1312 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1370
Query: 1048 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 1102
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1371 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1427
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1428 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1487
Score = 39.7 bits (91), Expect = 0.017
Identities = 46/177 (25%), Positives = 64/177 (36%), Gaps = 16/177 (9%)
Query: 436 PQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPI 495
P+ V +LSSTT L+ W +E V T + K +S
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKH--NVADSQITT 478
Query: 496 IENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIK----DLMLYPLGPTAVVLSWT 551
I NLVP Y V + GP S + I TG+ + P T+++LSWT
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQ-VITQTGVPGQPLNFKAEPESETSILLSWT 537
Query: 552 RPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRV 608
P Y E+ Y + E T+ S R+ L P Y FR+
Sbjct: 538 PPRSDTIANY--ELVY-------KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRL 585
Score = 31.6 bits (70), Expect = 4.7
Identities = 26/118 (22%), Positives = 43/118 (36%), Gaps = 3/118 (2%)
Query: 719 VKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVV 778
VK P PP + T TS+TL W Q + + +E V++
Sbjct: 319 VKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRY 378
Query: 779 TISSLLPATAYN---CSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
+++ L P + Y +V + PS P S P V +L+ + L+
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 436
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 224 bits (571), Expect = 4e-58
Identities = 124/348 (35%), Positives = 199/348 (57%), Gaps = 19/348 (5%)
Query: 828 ILSTLLIGLLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLT 887
+L+ + I +++ +++ + K + E + +S+ + ++P + + ++ R+L
Sbjct: 860 VLAVVFIICIVIAILLYKSKPDRKRAESDSRK----SSIPNNKEIPSHHPTDPVELRRLN 915
Query: 888 ---------NPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKN 938
P+ + + +I+ + + + KFS ++E + G ++L +N+ KN
Sbjct: 916 FQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDP-GQQFTWEHSNLEVNKPKN 974
Query: 939 RYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVL 998
RY N++ YD SRV L ++ G+DY+NANYI GY YIATQG LPET DFW+M+
Sbjct: 975 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1034
Query: 999 QQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--N 1056
+Q+S +VM+T+ E+ RVKCD YWP + +G + V ++ E + R F + N
Sbjct: 1035 EQRSATVVMMTKLEERSRVKCDQYWP-SRGTETHGLVQVTLLDTVELATYCVRTFALYKN 1093
Query: 1057 YADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTG 1116
+ E ++V F +TAWPDHGVP L F+ V+ GPM++HCSAGVGRTG
Sbjct: 1094 GSSEKREVRQFQFTAWPDHGVP--EHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTG 1151
Query: 1117 TFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
FI +D +L+ I+ + VDI G V+ MR+ R MVQTE+QYIFIH +
Sbjct: 1152 CFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1199
Score = 191 bits (484), Expect = 5e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 928 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 987
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1253 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1312
Query: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1313 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1371
Query: 1048 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 1102
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1372 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1428
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE+QY F ++
Sbjct: 1429 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYR 1488
Score = 39.7 bits (91), Expect = 0.017
Identities = 46/177 (25%), Positives = 64/177 (36%), Gaps = 16/177 (9%)
Query: 436 PQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPI 495
P+ V +LSSTT L+ W +E V T + K +S
Sbjct: 418 PRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKH--NVADSQITT 475
Query: 496 IENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIK----DLMLYPLGPTAVVLSWT 551
I NLVP Y V + GP S + I TG+ + P T+++LSWT
Sbjct: 476 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQ-VITQTGVPGQPLNFKAEPESETSILLSWT 534
Query: 552 RPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRV 608
P Y E+ Y + E T+ S R+ L P Y FR+
Sbjct: 535 PPRSDTIANY--ELVY-------KDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRL 582
Score = 31.6 bits (70), Expect = 4.7
Identities = 26/118 (22%), Positives = 43/118 (36%), Gaps = 3/118 (2%)
Query: 719 VKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVV 778
VK P PP + T TS+TL W Q + + +E V++
Sbjct: 316 VKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRY 375
Query: 779 TISSLLPATAYN---CSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
+++ L P + Y +V + PS P S P V +L+ + L+
Sbjct: 376 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILV 433
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 223 bits (569), Expect = 6e-58
Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)
Query: 889 PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 948
P+ + D + + + + K S ++E + G ++L +N+ KNRY N++ YD
Sbjct: 929 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 987
Query: 949 SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 1008
SRV L + G+DYINANY+ GY YIATQGPLPET DFW+MV +Q+S IVM+
Sbjct: 988 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1047
Query: 1009 TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 1066
T+ EK R+KCD YWP YG I V ++ E + R F + N + E ++V
Sbjct: 1048 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1106
Query: 1067 FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 1126
F +TAWPDHGVP L F+ V+ GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1107 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1164
Query: 1127 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
I+ + VD+ G V+ MRS R MVQTE+QY FIH+ +
Sbjct: 1165 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1202
Score = 191 bits (486), Expect = 3e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 928 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 987
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1256 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1315
Query: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1316 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1374
Query: 1048 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 1102
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1375 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1431
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE++Y F +Q
Sbjct: 1432 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1491
Score = 32.7 bits (73), Expect = 2.1
Identities = 41/176 (23%), Positives = 66/176 (37%), Gaps = 14/176 (7%)
Query: 436 PQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPI 495
P++V +LS+TT ++ W E V T + + +K +S
Sbjct: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVD--DSLLTT 478
Query: 496 IENLVPGAQYQVVIYLRKGPLIGPPSDPV---TFAIVPTGIKDLMLYPLGPTAVVLSWTR 552
+ +L+ Y V + GP SDP+ T VP +L T++ LSW+
Sbjct: 479 VGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSP 538
Query: 553 PYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRV 608
P KY + + E E+ T T S + +L P Y FR+
Sbjct: 539 PRQESIIKYEL---------LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRL 585
Score = 32.3 bits (72), Expect = 2.8
Identities = 36/162 (22%), Positives = 71/162 (43%), Gaps = 11/162 (6%)
Query: 679 KKSVTRNVMTAILSLPPGDIYNLSVTACTERG----SNTSMLRLVKLEPAPPKSLFAVNK 734
K +V +++T + SL + Y + V A T G S+ ++ + P P +L A +
Sbjct: 468 KHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR 527
Query: 735 TQTSVTLLWV---EEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNC 791
++TS+TL W +E + + +F + + + +P +S+VV L P T Y
Sbjct: 528 SETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDP--TTSYVV--EDLKPNTEYAF 583
Query: 792 SVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
+ + S T + + ++P + ++ S LL
Sbjct: 584 RLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTSVLL 625
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 223 bits (569), Expect = 6e-58
Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)
Query: 889 PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 948
P+ + D + + + + K S ++E + G ++L +N+ KNRY N++ YD
Sbjct: 1334 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 1392
Query: 949 SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 1008
SRV L + G+DYINANY+ GY YIATQGPLPET DFW+MV +Q+S IVM+
Sbjct: 1393 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1452
Query: 1009 TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 1066
T+ EK R+KCD YWP YG I V ++ E + R F + N + E ++V
Sbjct: 1453 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1511
Query: 1067 FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 1126
F +TAWPDHGVP L F+ V+ GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1512 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1569
Query: 1127 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
I+ + VD+ G V+ MRS R MVQTE+QY FIH+ +
Sbjct: 1570 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1607
Score = 191 bits (486), Expect = 3e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 928 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 987
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1661 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
Query: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1779
Query: 1048 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 1102
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1780 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1836
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE++Y F +Q
Sbjct: 1837 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1896
Score = 38.5 bits (88), Expect = 0.038
Identities = 76/389 (19%), Positives = 150/389 (38%), Gaps = 41/389 (10%)
Query: 436 PQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPI 495
P++V +LS+TT ++ W E V T + + +K +S
Sbjct: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVD--DSLLTT 474
Query: 496 IENLVPGAQYQVVIYLRKGPLIGPPSDPV---TFAIVPTGIKDLMLYPLGPTAVVLSWTR 552
+ +L+ Y V + GP SDP+ T VP +L T++ LSW+
Sbjct: 475 VGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSP 534
Query: 553 PYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVT 612
P KY + + E E+ T T S + +L P Y FR+
Sbjct: 535 PRQESIIKYEL---------LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA-- 583
Query: 613 WGDPELSCCDSSTI---SFITAPVAP--EITSVEYFNSLLYISWTYGDDTTD----LSHS 663
P+ + + + + P AP ++ V ++ + +SW T + +S
Sbjct: 584 -RSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYS 642
Query: 664 RMLHWMVVAEGKKKIKKSVTRNVMTAIL-SLPPGDIYNLSVTACTERGSNTSMLRLV--- 719
+ + + K + +L +L Y ++ A TE G +V
Sbjct: 643 VRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRT 702
Query: 720 --KLEPAPPKSLFAVNKTQTSVTLLW------VEEGVADFFEV-FCQQVGSSQK--TKLQ 768
+ APP+ + A T++ +LW + G ++V + + G+ + +++
Sbjct: 703 DEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIK 762
Query: 769 EPVAVSSHVVTISSLLPATAYNCSVTSFS 797
+ + + + I++L P TAY+ +V +++
Sbjct: 763 DVMLADAQEMVITNLQPETAYSITVAAYT 791
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 223 bits (569), Expect = 6e-58
Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)
Query: 889 PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 948
P+ + D + + + + K S ++E + G ++L +N+ KNRY N++ YD
Sbjct: 925 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 983
Query: 949 SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 1008
SRV L + G+DYINANY+ GY YIATQGPLPET DFW+MV +Q+S IVM+
Sbjct: 984 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1043
Query: 1009 TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 1066
T+ EK R+KCD YWP YG I V ++ E + R F + N + E ++V
Sbjct: 1044 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1102
Query: 1067 FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 1126
F +TAWPDHGVP L F+ V+ GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1103 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1160
Query: 1127 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
I+ + VD+ G V+ MRS R MVQTE+QY FIH+ +
Sbjct: 1161 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1198
Score = 191 bits (486), Expect = 3e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 928 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 987
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311
Query: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1312 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1370
Query: 1048 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 1102
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1371 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1427
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE++Y F +Q
Sbjct: 1428 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1487
Score = 32.7 bits (73), Expect = 2.1
Identities = 41/176 (23%), Positives = 66/176 (37%), Gaps = 14/176 (7%)
Query: 436 PQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPI 495
P++V +LS+TT ++ W E V T + + +K +S
Sbjct: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVD--DSLLTT 474
Query: 496 IENLVPGAQYQVVIYLRKGPLIGPPSDPV---TFAIVPTGIKDLMLYPLGPTAVVLSWTR 552
+ +L+ Y V + GP SDP+ T VP +L T++ LSW+
Sbjct: 475 VGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSP 534
Query: 553 PYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRV 608
P KY + + E E+ T T S + +L P Y FR+
Sbjct: 535 PRQESIIKYEL---------LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRL 581
Score = 32.3 bits (72), Expect = 2.8
Identities = 36/162 (22%), Positives = 71/162 (43%), Gaps = 11/162 (6%)
Query: 679 KKSVTRNVMTAILSLPPGDIYNLSVTACTERG----SNTSMLRLVKLEPAPPKSLFAVNK 734
K +V +++T + SL + Y + V A T G S+ ++ + P P +L A +
Sbjct: 464 KHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR 523
Query: 735 TQTSVTLLWV---EEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISSLLPATAYNC 791
++TS+TL W +E + + +F + + + +P +S+VV L P T Y
Sbjct: 524 SETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDP--TTSYVV--EDLKPNTEYAF 579
Query: 792 SVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLL 833
+ + S T + + ++P + ++ S LL
Sbjct: 580 RLAARSPQGLGAFTPVVRQRTLQSISPKNFKVKMIMKTSVLL 621
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 223 bits (569), Expect = 6e-58
Identities = 118/278 (42%), Positives = 165/278 (59%), Gaps = 6/278 (2%)
Query: 889 PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDF 948
P+ + D + + + + K S ++E + G ++L +N+ KNRY N++ YD
Sbjct: 1372 PIPIADMAEHTERLKANDSLKLSQEYESIDP-GQQFTWEHSNLEVNKPKNRYANVIAYDH 1430
Query: 949 SRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVML 1008
SRV L + G+DYINANY+ GY YIATQGPLPET DFW+MV +Q+S IVM+
Sbjct: 1431 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1490
Query: 1009 TQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEMQDVMH 1066
T+ EK R+KCD YWP YG I V ++ E + R F + N + E ++V
Sbjct: 1491 TRLEEKSRIKCDQYWP-NRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1549
Query: 1067 FNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 1126
F +TAWPDHGVP L F+ V+ GP+++HCSAGVGRTG FI +D +L+
Sbjct: 1550 FQFTAWPDHGVP--EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1607
Query: 1127 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
I+ + VD+ G V+ MRS R MVQTE+QY FIH+ +
Sbjct: 1608 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1645
Score = 191 bits (486), Expect = 3e-48
Identities = 103/240 (42%), Positives = 144/240 (60%), Gaps = 9/240 (3%)
Query: 928 AADLPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLP 987
+A+LP N+ KNR NI+PY+ +RV L + EG+DYINA++I GY + YIATQGPL
Sbjct: 1699 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1758
Query: 988 ETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDD 1047
ET DFW+M+ + S I+VMLT+ E R KC YWP E Y V+ ++E
Sbjct: 1759 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAEYNMPQ 1817
Query: 1048 WACRHFRINYADEMQD--VMHFNYTAWPDHGVPTANAAESILQF---VHMVRQQATKSKG 1102
+ R F++ A + Q V F +T WP+ GVP + E + F VH ++Q + G
Sbjct: 1818 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVP--KSGEGFIDFIGQVHKTKEQFGQD-G 1874
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
P+ +HCSAGVGRTG FI L +L+ +R VDI V +R+ R +MVQTE++Y F +Q
Sbjct: 1875 PISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQ 1934
Score = 32.7 bits (73), Expect = 2.1
Identities = 41/176 (23%), Positives = 66/176 (37%), Gaps = 14/176 (7%)
Query: 436 PQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPI 495
P++V +LS+TT ++ W E V T + + +K +S
Sbjct: 430 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVD--DSLLTT 487
Query: 496 IENLVPGAQYQVVIYLRKGPLIGPPSDPV---TFAIVPTGIKDLMLYPLGPTAVVLSWTR 552
+ +L+ Y V + GP SDP+ T VP +L T++ LSW+
Sbjct: 488 VGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSP 547
Query: 553 PYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRV 608
P KY + + E E+ T T S + +L P Y FR+
Sbjct: 548 PRQESIIKYEL---------LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRL 594
Score = 31.2 bits (69), Expect = 6.1
Identities = 20/69 (28%), Positives = 36/69 (52%), Gaps = 4/69 (5%)
Query: 679 KKSVTRNVMTAILSLPPGDIYNLSVTACTERG----SNTSMLRLVKLEPAPPKSLFAVNK 734
K +V +++T + SL + Y + V A T G S+ ++ + P P +L A +
Sbjct: 477 KHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEAR 536
Query: 735 TQTSVTLLW 743
++TS+TL W
Sbjct: 537 SETSITLSW 545
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 222 bits (566), Expect = 1e-57
Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 7/277 (2%)
Query: 890 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 949
+++ D +I M + Y F ++E L G A NR KNRY NI+ YD S
Sbjct: 869 IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 927
Query: 950 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 1009
RVRL+ ++ + +DYINANYI GY+ P+ YIATQGP+ ET DFW+M+ Q+ S IVM+T
Sbjct: 928 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 987
Query: 1010 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHF 1067
E RVKC YWP ++ YGDI V +I E ++ R F + E++++ F
Sbjct: 988 NLVEVGRVKCVRYWP--DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1045
Query: 1068 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 1127
++T+WPDHGVP A +L FV V+ GP+++HCSAG GRTG FIA+D +L
Sbjct: 1046 HFTSWPDHGVPC--YATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1103
Query: 1128 IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
+ VDI V E+R+ R+++VQTEEQY+F+H +
Sbjct: 1104 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1140
Score = 128 bits (321), Expect = 4e-29
Identities = 78/239 (32%), Positives = 125/239 (52%), Gaps = 12/239 (5%)
Query: 931 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 990
LP N KNR ++LP D L+S+ + E ++YINA + + P ++ TQ PLP T
Sbjct: 1199 LPRNHDKNRSMDVLPLDRCLPFLISV-DGESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1257
Query: 991 NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWAC 1050
DFW++V +VML + + + C YWP + YG I VE +S + +D
Sbjct: 1258 ADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWP-EKTSGCYGPIQVEFVSADIDEDIIH 1314
Query: 1051 RHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKGP 1103
R FRI QD V H Y WP + T + S+L+ V + ++Q +G
Sbjct: 1315 RIFRICNMARPQDGYRIVQHLQYIGWPAYR-DTPPSKRSLLKVVRRLEKWQEQYDGREGR 1373
Query: 1104 MIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
++HC G GR+GTF A+ + + I+ +D+ +V +R+ + +MV+T EQY F+++
Sbjct: 1374 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYE 1432
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 222 bits (566), Expect = 1e-57
Identities = 118/277 (42%), Positives = 167/277 (60%), Gaps = 7/277 (2%)
Query: 890 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 949
+++ D +I M + Y F ++E L G A NR KNRY NI+ YD S
Sbjct: 888 IRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHS 946
Query: 950 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 1009
RVRL+ ++ + +DYINANYI GY+ P+ YIATQGP+ ET DFW+M+ Q+ S IVM+T
Sbjct: 947 RVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT 1006
Query: 1010 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYA--DEMQDVMHF 1067
E RVKC YWP ++ YGDI V +I E ++ R F + E++++ F
Sbjct: 1007 NLVEVGRVKCVRYWP--DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLF 1064
Query: 1068 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 1127
++T+WPDHGVP A +L FV V+ GP+++HCSAG GRTG FIA+D +L
Sbjct: 1065 HFTSWPDHGVPC--YATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1122
Query: 1128 IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
+ VDI V E+R+ R+++VQTEEQY+F+H +
Sbjct: 1123 AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
Score = 128 bits (321), Expect = 4e-29
Identities = 78/239 (32%), Positives = 125/239 (52%), Gaps = 12/239 (5%)
Query: 931 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 990
LP N KNR ++LP D L+S+ + E ++YINA + + P ++ TQ PLP T
Sbjct: 1218 LPRNHDKNRSMDVLPLDRCLPFLISV-DGESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1276
Query: 991 NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWAC 1050
DFW++V +VML + + + C YWP + YG I VE +S + +D
Sbjct: 1277 ADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWP-EKTSGCYGPIQVEFVSADIDEDIIH 1333
Query: 1051 RHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKGP 1103
R FRI QD V H Y WP + T + S+L+ V + ++Q +G
Sbjct: 1334 RIFRICNMARPQDGYRIVQHLQYIGWPAYR-DTPPSKRSLLKVVRRLEKWQEQYDGREGR 1392
Query: 1104 MIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
++HC G GR+GTF A+ + + I+ +D+ +V +R+ + +MV+T EQY F+++
Sbjct: 1393 TVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYE 1451
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 221 bits (564), Expect = 2e-57
Identities = 133/390 (34%), Positives = 200/390 (51%), Gaps = 26/390 (6%)
Query: 780 ISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLV 839
+ L +T Y + D P P + ST +++A L+ L+I +
Sbjct: 491 VKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSK-------ALIAFLAFLIIVTSIA 543
Query: 840 TLIILRKKH-LQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDDFDAY 898
L++L K + L R C +ERD + K+ P+ D
Sbjct: 544 LLVVLYKIYDLHKKRSCNLDEQQEL--VERDDE----------KQLMNVEPIHADILLET 591
Query: 899 IKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNE 958
K D F +F+ + + P A P N+ KNRY +ILPYD++RV L +N
Sbjct: 592 YKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEING 651
Query: 959 EEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVK 1018
+ G++YINA+YI G+ P++YIA QGP ET +DFW+M+ +QK+ +IVM+T+C E R K
Sbjct: 652 DAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNK 711
Query: 1019 CDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYADEM---QDVMHFNYTAWPD 1074
C YWP EE A+GD+ V++ + D+ + I E ++V H +T+WPD
Sbjct: 712 CAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPD 771
Query: 1075 HGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFV 1134
HGVP +L+ V + GP+++HCSAGVGRTGT+I +D +L+ + V
Sbjct: 772 HGVP--EDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKV 829
Query: 1135 DILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
D+ G V ++R R MVQ E QYI IHQ +
Sbjct: 830 DVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859
Score = 140 bits (354), Expect = 6e-33
Identities = 87/260 (33%), Positives = 129/260 (49%), Gaps = 31/260 (11%)
Query: 934 NRCKNRYTNILPYDFSRVRLV-------------------SMNEEEGADYINANYIPGYN 974
N+ KNR +N++PYD++RV L + EE + YINA++I Y
Sbjct: 918 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 977
Query: 975 SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGD 1034
P+ IA QGPL ET DFW+M+ Q+K ++IVMLT+ + C YW E YGD
Sbjct: 978 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW--GEGKQTYGD 1035
Query: 1035 ITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVH 1091
I V++ ++ + R F + ++ + + V + YT W +P S++Q V
Sbjct: 1036 IEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK 1095
Query: 1092 MVRQQATKSKG-------PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMR 1144
Q S+G P++IHC G +TG F AL LL+ E VDI +V +R
Sbjct: 1096 QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALR 1155
Query: 1145 SYRMSMVQTEEQYIFIHQCV 1164
R MV T EQY F++ +
Sbjct: 1156 KARPGMVSTFEQYQFLYDVI 1175
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 221 bits (564), Expect = 2e-57
Identities = 133/390 (34%), Positives = 200/390 (51%), Gaps = 26/390 (6%)
Query: 780 ISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLV 839
+ L +T Y + D P P + ST +++A L+ L+I +
Sbjct: 539 VKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSK-------ALIAFLAFLIIVTSIA 591
Query: 840 TLIILRKKH-LQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDDFDAY 898
L++L K + L R C +ERD + K+ P+ D
Sbjct: 592 LLVVLYKIYDLHKKRSCNLDEQQEL--VERDDE----------KQLMNVEPIHADILLET 639
Query: 899 IKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNE 958
K D F +F+ + + P A P N+ KNRY +ILPYD++RV L +N
Sbjct: 640 YKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEING 699
Query: 959 EEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVK 1018
+ G++YINA+YI G+ P++YIA QGP ET +DFW+M+ +QK+ +IVM+T+C E R K
Sbjct: 700 DAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNK 759
Query: 1019 CDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYADEM---QDVMHFNYTAWPD 1074
C YWP EE A+GD+ V++ + D+ + I E ++V H +T+WPD
Sbjct: 760 CAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPD 819
Query: 1075 HGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFV 1134
HGVP +L+ V + GP+++HCSAGVGRTGT+I +D +L+ + V
Sbjct: 820 HGVP--EDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKV 877
Query: 1135 DILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
D+ G V ++R R MVQ E QYI IHQ +
Sbjct: 878 DVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907
Score = 140 bits (354), Expect = 6e-33
Identities = 87/260 (33%), Positives = 129/260 (49%), Gaps = 31/260 (11%)
Query: 934 NRCKNRYTNILPYDFSRVRLV-------------------SMNEEEGADYINANYIPGYN 974
N+ KNR +N++PYD++RV L + EE + YINA++I Y
Sbjct: 966 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 1025
Query: 975 SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGD 1034
P+ IA QGPL ET DFW+M+ Q+K ++IVMLT+ + C YW E YGD
Sbjct: 1026 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW--GEGKQTYGD 1083
Query: 1035 ITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVH 1091
I V++ ++ + R F + ++ + + V + YT W +P S++Q V
Sbjct: 1084 IEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK 1143
Query: 1092 MVRQQATKSKG-------PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMR 1144
Q S+G P++IHC G +TG F AL LL+ E VDI +V +R
Sbjct: 1144 QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALR 1203
Query: 1145 SYRMSMVQTEEQYIFIHQCV 1164
R MV T EQY F++ +
Sbjct: 1204 KARPGMVSTFEQYQFLYDVI 1223
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 221 bits (564), Expect = 2e-57
Identities = 133/390 (34%), Positives = 200/390 (51%), Gaps = 26/390 (6%)
Query: 780 ISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLV 839
+ L +T Y + D P P + ST +++A L+ L+I +
Sbjct: 378 VKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSK-------ALIAFLAFLIIVTSIA 430
Query: 840 TLIILRKKH-LQMARECGAGTFVNFASLERDGKLPYNWSKNGLKKRKLTNPVQLDDFDAY 898
L++L K + L R C +ERD + K+ P+ D
Sbjct: 431 LLVVLYKIYDLHKKRSCNLDEQQEL--VERDDE----------KQLMNVEPIHADILLET 478
Query: 899 IKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNE 958
K D F +F+ + + P A P N+ KNRY +ILPYD++RV L +N
Sbjct: 479 YKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEING 538
Query: 959 EEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVK 1018
+ G++YINA+YI G+ P++YIA QGP ET +DFW+M+ +QK+ +IVM+T+C E R K
Sbjct: 539 DAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNK 598
Query: 1019 CDHYWPFTEEPI-AYGDITVEMISEEEQDDWACRHFRINYADEM---QDVMHFNYTAWPD 1074
C YWP EE A+GD+ V++ + D+ + I E ++V H +T+WPD
Sbjct: 599 CAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPD 658
Query: 1075 HGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFV 1134
HGVP +L+ V + GP+++HCSAGVGRTGT+I +D +L+ + V
Sbjct: 659 HGVP--EDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKV 716
Query: 1135 DILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
D+ G V ++R R MVQ E QYI IHQ +
Sbjct: 717 DVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746
Score = 140 bits (354), Expect = 6e-33
Identities = 87/260 (33%), Positives = 129/260 (49%), Gaps = 31/260 (11%)
Query: 934 NRCKNRYTNILPYDFSRVRLV-------------------SMNEEEGADYINANYIPGYN 974
N+ KNR +N++PYD++RV L + EE + YINA++I Y
Sbjct: 805 NKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYW 864
Query: 975 SPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGD 1034
P+ IA QGPL ET DFW+M+ Q+K ++IVMLT+ + C YW E YGD
Sbjct: 865 KPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW--GEGKQTYGD 922
Query: 1035 ITVEMISEEEQDDWACRHFRINYA--DEMQDVMHFNYTAWPDHGVPT-ANAAESILQFVH 1091
I V++ ++ + R F + ++ + + V + YT W +P S++Q V
Sbjct: 923 IEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVK 982
Query: 1092 MVRQQATKSKG-------PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMR 1144
Q S+G P++IHC G +TG F AL LL+ E VDI +V +R
Sbjct: 983 QKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALR 1042
Query: 1145 SYRMSMVQTEEQYIFIHQCV 1164
R MV T EQY F++ +
Sbjct: 1043 KARPGMVSTFEQYQFLYDVI 1062
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 219 bits (558), Expect = 1e-56
Identities = 117/277 (42%), Positives = 162/277 (58%), Gaps = 7/277 (2%)
Query: 890 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 949
+++ D +I M Y F ++E G P +A NR KNRY NI+ YD S
Sbjct: 880 IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 938
Query: 950 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 1009
RVRL ++ + +DYIN NYI GY+ P YIATQGP+ ET DFW+MV + + I+M+T
Sbjct: 939 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 998
Query: 1010 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHF 1067
E RVKC YWP ++ Y DI V +I E ++ R F + E++++ F
Sbjct: 999 NLVEVGRVKCCKYWP--DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQF 1056
Query: 1068 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 1127
++T WPDHGVP A +L FV V+ ++ S GP+++HCSAG GRTG FI +D +L
Sbjct: 1057 HFTGWPDHGVP--YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1114
Query: 1128 IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
VDI V E+RS R++MVQTEEQY+FIH +
Sbjct: 1115 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1151
Score = 122 bits (306), Expect = 2e-27
Identities = 79/240 (32%), Positives = 123/240 (51%), Gaps = 14/240 (5%)
Query: 931 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 990
LP N KNR +ILP D L+++ + E ++YINA + Y P +I TQ PLP T
Sbjct: 1210 LPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTV 1268
Query: 991 NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWA 1049
DFW++VL +VML + + C YWP E + +G I VE +S + ++D
Sbjct: 1269 KDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWP--ENGVHRHGPIQVEFVSADLEEDII 1324
Query: 1050 CRHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKG 1102
R FRI A QD V F + WP + T + S L+ + V +++ +G
Sbjct: 1325 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYR-DTPVSKRSFLKLIRQVDKWQEEYNGGEG 1383
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
++HC G GR+GTF A+ + + +R VD+ V +R+ + +MV +QY F ++
Sbjct: 1384 RTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE 1443
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 219 bits (558), Expect = 1e-56
Identities = 117/277 (42%), Positives = 162/277 (58%), Gaps = 7/277 (2%)
Query: 890 VQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFS 949
+++ D +I M Y F ++E G P +A NR KNRY NI+ YD S
Sbjct: 893 IRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 951
Query: 950 RVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLT 1009
RVRL ++ + +DYIN NYI GY+ P YIATQGP+ ET DFW+MV + + I+M+T
Sbjct: 952 RVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVT 1011
Query: 1010 QCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINY--ADEMQDVMHF 1067
E RVKC YWP ++ Y DI V +I E ++ R F + E++++ F
Sbjct: 1012 NLVEVGRVKCCKYWP--DDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQF 1069
Query: 1068 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQH 1127
++T WPDHGVP A +L FV V+ ++ S GP+++HCSAG GRTG FI +D +L
Sbjct: 1070 HFTGWPDHGVP--YHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDM 1127
Query: 1128 IRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1164
VDI V E+RS R++MVQTEEQY+FIH +
Sbjct: 1128 AEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1164
Score = 122 bits (306), Expect = 2e-27
Identities = 79/240 (32%), Positives = 123/240 (51%), Gaps = 14/240 (5%)
Query: 931 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETR 990
LP N KNR +ILP D L+++ + E ++YINA + Y P +I TQ PLP T
Sbjct: 1223 LPRNHEKNRCMDILPPDRCLPFLITI-DGESSNYINAALMDSYKQPSAFIVTQHPLPNTV 1281
Query: 991 NDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPI-AYGDITVEMISEEEQDDWA 1049
DFW++VL +VML + + C YWP E + +G I VE +S + ++D
Sbjct: 1282 KDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWP--ENGVHRHGPIQVEFVSADLEEDII 1337
Query: 1050 CRHFRINYADEMQD----VMHFNYTAWPDHGVPTANAAESILQFVHMV---RQQATKSKG 1102
R FRI A QD V F + WP + T + S L+ + V +++ +G
Sbjct: 1338 SRIFRIYNAARPQDGYRMVQQFQFLGWPMYR-DTPVSKRSFLKLIRQVDKWQEEYNGGEG 1396
Query: 1103 PMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQ 1162
++HC G GR+GTF A+ + + +R VD+ V +R+ + +MV +QY F ++
Sbjct: 1397 RTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYE 1456
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,290,133
Number of Sequences: 37866
Number of extensions: 2097700
Number of successful extensions: 6480
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 5394
Number of HSP's gapped (non-prelim): 763
length of query: 1188
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1075
effective length of database: 13,968,660
effective search space: 15016309500
effective search space used: 15016309500
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.