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Search of human proteins with 4506103
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506103 eukaryotic translation initiation factor 2-alpha
kinase 2 isoform a [Homo sapiens]
(551 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208431827 eukaryotic translation initiation factor 2-alpha ki... 1096 0.0
gi|4506103 eukaryotic translation initiation factor 2-alpha kina... 1096 0.0
gi|208431829 eukaryotic translation initiation factor 2-alpha ki... 993 0.0
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 138 1e-32
gi|134304838 eukaryotic translation initiation factor 2-alpha ki... 131 1e-30
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 119 7e-27
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 117 2e-26
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 115 8e-26
gi|65287717 eukaryotic translation initiation factor 2 alpha kin... 115 1e-25
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 113 5e-25
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 112 9e-25
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 112 9e-25
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 112 9e-25
gi|93004081 polo-like kinase 2 [Homo sapiens] 105 1e-22
gi|21359873 polo-like kinase 1 [Homo sapiens] 104 2e-22
gi|197245437 eukaryotic translation initiation factor 2-alpha ki... 103 3e-22
gi|11125768 eukaryotic translation initiation factor 2-alpha kin... 103 3e-22
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 103 4e-22
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 103 4e-22
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 103 4e-22
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 103 4e-22
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 103 4e-22
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 103 4e-22
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 103 4e-22
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 103 4e-22
gi|41872374 polo-like kinase 3 [Homo sapiens] 100 3e-21
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 100 6e-21
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 100 6e-21
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 99 1e-20
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 97 3e-20
>gi|208431827 eukaryotic translation initiation factor 2-alpha
kinase 2 isoform a [Homo sapiens]
Length = 551
Score = 1096 bits (2835), Expect = 0.0
Identities = 551/551 (100%), Positives = 551/551 (100%)
Query: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
Sbjct: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
Query: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
Sbjct: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
Query: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
Sbjct: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
Query: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
Sbjct: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
Query: 241 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY 300
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
Sbjct: 241 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY 300
Query: 301 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 360
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
Sbjct: 301 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 360
Query: 361 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
Sbjct: 361 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
Query: 421 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 480
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
Sbjct: 421 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 480
Query: 481 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 540
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
Sbjct: 481 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 540
Query: 541 KSPEKNERHTC 551
KSPEKNERHTC
Sbjct: 541 KSPEKNERHTC 551
>gi|4506103 eukaryotic translation initiation factor 2-alpha kinase
2 isoform a [Homo sapiens]
Length = 551
Score = 1096 bits (2835), Expect = 0.0
Identities = 551/551 (100%), Positives = 551/551 (100%)
Query: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
Sbjct: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
Query: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
Sbjct: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
Query: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
Sbjct: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
Query: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
Sbjct: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
Query: 241 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY 300
RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
Sbjct: 241 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY 300
Query: 301 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 360
NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
Sbjct: 301 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 360
Query: 361 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
Sbjct: 361 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
Query: 421 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 480
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
Sbjct: 421 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 480
Query: 481 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 540
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
Sbjct: 481 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 540
Query: 541 KSPEKNERHTC 551
KSPEKNERHTC
Sbjct: 541 KSPEKNERHTC 551
>gi|208431829 eukaryotic translation initiation factor 2-alpha
kinase 2 isoform b [Homo sapiens]
Length = 510
Score = 993 bits (2567), Expect = 0.0
Identities = 510/551 (92%), Positives = 510/551 (92%), Gaps = 41/551 (7%)
Query: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
Sbjct: 1 MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK 60
Query: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
Sbjct: 61 KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ 120
Query: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
Sbjct: 121 CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG 180
Query: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
Sbjct: 181 SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK 240
Query: 241 RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY 300
RSLAPRFDLPDMKETKYTVDKR
Sbjct: 241 RSLAPRFDLPDMKETKYTVDKR-------------------------------------- 262
Query: 301 NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 360
KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
Sbjct: 263 ---KAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 319
Query: 361 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
Sbjct: 320 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 379
Query: 421 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 480
FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
Sbjct: 380 FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE 439
Query: 481 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 540
LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
Sbjct: 440 LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK 499
Query: 541 KSPEKNERHTC 551
KSPEKNERHTC
Sbjct: 500 KSPEKNERHTC 510
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 138 bits (348), Expect = 1e-32
Identities = 87/277 (31%), Positives = 141/277 (50%), Gaps = 40/277 (14%)
Query: 270 IELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEK------AEREVKALAKLDHVNIVHY 323
+ ++G G +G+V KHR DGK YVIK++ N AE+E + L++L H NIV Y
Sbjct: 9 LRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNIVTY 68
Query: 324 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG 383
W+G D L+I M FC+ G L + +++++G
Sbjct: 69 KESWEGGD----------------------------GLLYIVMGFCEGGDLYRKLKEQKG 100
Query: 384 EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDG 443
+ L + +E F QI + Y+H K ++HRDLK N+FL T +K+GD G+ L+N
Sbjct: 101 QLLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHC 160
Query: 444 KRTRSK-GTLRYMSPEQISSQDYGKEVDLYALGLILAEL--LHVCDTAFETSKFFTDLRD 500
+ GT YMSPE S++ Y + D++ALG + E+ L A + + + +
Sbjct: 161 DMASTLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIE 220
Query: 501 GIISDI---FDKKEKTLLQKLLSKKPEDRPNTSEILR 534
G + + + + L++ +LSK+PE+RP+ ILR
Sbjct: 221 GKLPPMPRDYSPELAELIRTMLSKRPEERPSVRSILR 257
>gi|134304838 eukaryotic translation initiation factor 2-alpha kinase
3 [Homo sapiens]
Length = 1116
Score = 131 bits (330), Expect = 1e-30
Identities = 75/189 (39%), Positives = 108/189 (57%), Gaps = 17/189 (8%)
Query: 362 LFIQMEFCDKGTLEQWIEKRRG-EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
L+IQM+ C K L+ W+ R E+ ++ + L +F QI + V+++HSK L+HRDLKPSNI
Sbjct: 884 LYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNI 943
Query: 421 FLVDTKQVKIGDFGLVTSLKND-------------GKRTRSKGTLRYMSPEQISSQDYGK 467
F VK+GDFGLVT++ D + T GT YMSPEQI Y
Sbjct: 944 FFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSH 1003
Query: 468 EVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPE 524
+VD+++LGLIL ELL+ T E + TD+R+ +F +K E ++Q +LS P
Sbjct: 1004 KVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPM 1063
Query: 525 DRPNTSEIL 533
+RP I+
Sbjct: 1064 ERPEAINII 1072
Score = 71.2 bits (173), Expect = 2e-12
Identities = 38/82 (46%), Positives = 51/82 (62%), Gaps = 7/82 (8%)
Query: 251 DMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-----EKA 305
D+K + Y R+ DF+ I+ +G GGFG VF+AK+++D Y IKR++ N EK
Sbjct: 579 DIKNSGYI--SRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKV 636
Query: 306 EREVKALAKLDHVNIVHYNGCW 327
REVKALAKL+H IV Y W
Sbjct: 637 MREVKALAKLEHPGIVRYFNAW 658
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 119 bits (298), Expect = 7e-27
Identities = 88/289 (30%), Positives = 134/289 (46%), Gaps = 64/289 (22%)
Query: 270 IELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN------EKAEREVKALAKLDHVNIVHY 323
I+ IG G FG+ + AK + D K VIK + + E +++EV L K+ H NIV +
Sbjct: 7 IKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNIVAF 66
Query: 324 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG 383
+ EN + LFI ME+CD G L + I ++RG
Sbjct: 67 FNSFQ--------------------ENGR---------LFIVMEYCDGGDLMKRINRQRG 97
Query: 384 EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQV-KIGDFGLVTSLKND 442
+ L F QI+ G+ +IH +K++HRD+K NIFL V K+GDFG+ L N
Sbjct: 98 VLFSEDQILGWFVQISLGLKHIHDRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNS 157
Query: 443 GKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILAEL----------------LHVC 485
+ R+ GT Y+SPE ++ Y + D+++LG +L EL L +C
Sbjct: 158 MELARTCIGTPYYLSPEICQNKPYNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKIC 217
Query: 486 DTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
F IS F ++ +L+ +L P DRP+ + IL+
Sbjct: 218 QAHFAP-----------ISPGFSRELHSLISQLFQVSPRDRPSINSILK 255
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 117 bits (294), Expect = 2e-26
Identities = 84/281 (29%), Positives = 134/281 (47%), Gaps = 45/281 (16%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN------EKAEREVKALAKLDHVNI 320
+ ++ IG G FG+ K DG+ YVIK + + E++ REV LA + H NI
Sbjct: 4 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
Query: 321 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 380
V Y ++ +N S L+I M++C+ G L + I
Sbjct: 64 VQYRESFE-----------------------ENGS------LYIVMDYCEGGDLFKRINA 94
Query: 381 RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLK 440
++G + L+ F QI + ++H +K++HRD+K NIFL V++GDFG+ L
Sbjct: 95 QKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLN 154
Query: 441 NDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLR 499
+ + R+ GT Y+SPE ++ Y + D++ALG +L EL AFE +L
Sbjct: 155 STVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELC-TLKHAFEAGS-MKNLV 212
Query: 500 DGIISDIFDKKE-------KTLLQKLLSKKPEDRPNTSEIL 533
IIS F ++L+ +L + P DRP+ + IL
Sbjct: 213 LKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSIL 253
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 115 bits (289), Expect = 8e-26
Identities = 89/287 (31%), Positives = 142/287 (49%), Gaps = 46/287 (16%)
Query: 266 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-EKAER-----EVKALAKLDHVN 319
D++ + IG+G +G+ K + + DGK V K + Y + +AE+ EV L +L H N
Sbjct: 7 DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPN 66
Query: 320 IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIE 379
IV Y YD + R+ T L+I ME+C+ G L I
Sbjct: 67 IVRY----------------------YD----RIIDRTNTT-LYIVMEYCEGGDLASVIT 99
Query: 380 KRRGEK--LDKVLALELFEQITKGVDYIHSKK-----LIHRDLKPSNIFLVDTKQVKIGD 432
K E+ LD+ L + Q+T + H + ++HRDLKP+N+FL + VK+GD
Sbjct: 100 KGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGD 159
Query: 433 FGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCD--TAF 489
FGL L +D ++ GT YMSPEQ++ Y ++ D+++LG +L EL + TAF
Sbjct: 160 FGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAF 219
Query: 490 ETSKFFTDLRDGIISDI---FDKKEKTLLQKLLSKKPEDRPNTSEIL 533
+ +R+G I + + ++ ++L+ K RP+ EIL
Sbjct: 220 SQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEIL 266
>gi|65287717 eukaryotic translation initiation factor 2 alpha kinase 4
[Homo sapiens]
Length = 1649
Score = 115 bits (287), Expect = 1e-25
Identities = 88/254 (34%), Positives = 123/254 (48%), Gaps = 36/254 (14%)
Query: 330 FDYDPETSDDSLESSDYDPENSKNSSRSKTKC-----LFIQMEFCDKGTLEQWIEKRRGE 384
FD + E S + D + +N + S L+IQME+C+K TL I++ G
Sbjct: 761 FDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ--GL 818
Query: 385 KLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTS------ 438
D V LF +I G+ YIH K +IHRDLKP NIFL VKIGDFGL T
Sbjct: 819 YRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSA 878
Query: 439 -----------LKND--GKRTRSKGTLRYMSPEQISS--QDYGKEVDLYALGLILAEL-L 482
+K+D G T GT Y+SPE S Y ++VDL++LG+I E+
Sbjct: 879 DSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSY 938
Query: 483 HVCDTAFETSKFFTDLRDGI---ISDIFD----KKEKTLLQKLLSKKPEDRPNTSEILRT 535
H TA E LRD + FD K+K+++ LL+ P RP +E+L++
Sbjct: 939 HPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKS 998
Query: 536 LTVWKKSPEKNERH 549
+ E++E H
Sbjct: 999 ELLPPPQMEESELH 1012
Score = 57.8 bits (138), Expect = 3e-08
Identities = 26/71 (36%), Positives = 43/71 (60%), Gaps = 5/71 (7%)
Query: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-----EKAEREVKALAKLD 316
R+ ++F+E++L+G G FG V K ++++DG Y +KR+ N + + EV L++L
Sbjct: 585 RYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLH 644
Query: 317 HVNIVHYNGCW 327
H NIV Y W
Sbjct: 645 HENIVRYYNAW 655
Score = 43.1 bits (100), Expect = 7e-04
Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 397 QITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMS 456
Q+ G+DY+HS ++H+ L SN+ + VKI D+ + L + K + T R
Sbjct: 408 QLLSGLDYLHSNSVVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQT-RVRF 466
Query: 457 PEQISSQDYGKEVDLYALGLILAEL 481
+ GK+ D++ LGL+L L
Sbjct: 467 SDNALPYKTGKKGDVWRLGLLLLSL 491
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 113 bits (282), Expect = 5e-25
Identities = 84/280 (30%), Positives = 131/280 (46%), Gaps = 43/280 (15%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRV------KYNNEKAEREVKALAKLDHVNI 320
++ I ++G G FG V + D K +IK++ K + A+ E + L L+H N+
Sbjct: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Query: 321 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 380
+ Y ++ F D K L I ME+ GTL ++I+K
Sbjct: 64 IEY---YENFLED--------------------------KALMIAMEYAPGGTLAEFIQK 94
Query: 381 RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ-VKIGDFGLVTSL 439
R L++ L F QI + ++H+ ++HRDLK NI L + VKIGDFG+ L
Sbjct: 95 RCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKIL 154
Query: 440 KNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSK---FFT 496
+ K GT Y+SPE + Y ++ D++ALG +L EL + AFE +
Sbjct: 155 SSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASL-KRAFEAANLPALVL 213
Query: 497 DLRDGI---ISDIFDKKEKTLLQKLLSKKPEDRPNTSEIL 533
+ G ISD + + + L+ LLS +P RP S I+
Sbjct: 214 KIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIM 253
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 112 bits (280), Expect = 9e-25
Identities = 77/279 (27%), Positives = 132/279 (47%), Gaps = 40/279 (14%)
Query: 266 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY-----NNEKAEREVKALAKLDHVNI 320
D+ + +IG G FG+ +H + + +K ++ N + + +E LAK+ H NI
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNI 62
Query: 321 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 380
V + +S E+ + L+I ME+CD G L Q I++
Sbjct: 63 VAFK--------------ESFEAEGH---------------LYIVMEYCDGGDLMQKIKQ 93
Query: 381 RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLK 440
++G+ + + L F Q+ GV++IH K+++HRD+K NIFL +VK+GDFG L
Sbjct: 94 QKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLS 153
Query: 441 ND-GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL--LHVCDTAFETSKFFTD 497
N GT Y+ PE + Y + D+++LG IL EL L A
Sbjct: 154 NPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILK 213
Query: 498 LRDGIISDI---FDKKEKTLLQKLLSKKPEDRPNTSEIL 533
+ G IS + + + + L++++ + P RP+ + +L
Sbjct: 214 VCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLL 252
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 112 bits (280), Expect = 9e-25
Identities = 77/279 (27%), Positives = 132/279 (47%), Gaps = 40/279 (14%)
Query: 266 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY-----NNEKAEREVKALAKLDHVNI 320
D+ + +IG G FG+ +H + + +K ++ N + + +E LAK+ H NI
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNI 62
Query: 321 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 380
V + +S E+ + L+I ME+CD G L Q I++
Sbjct: 63 VAFK--------------ESFEAEGH---------------LYIVMEYCDGGDLMQKIKQ 93
Query: 381 RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLK 440
++G+ + + L F Q+ GV++IH K+++HRD+K NIFL +VK+GDFG L
Sbjct: 94 QKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLS 153
Query: 441 ND-GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL--LHVCDTAFETSKFFTD 497
N GT Y+ PE + Y + D+++LG IL EL L A
Sbjct: 154 NPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILK 213
Query: 498 LRDGIISDI---FDKKEKTLLQKLLSKKPEDRPNTSEIL 533
+ G IS + + + + L++++ + P RP+ + +L
Sbjct: 214 VCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLL 252
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 112 bits (280), Expect = 9e-25
Identities = 77/279 (27%), Positives = 132/279 (47%), Gaps = 40/279 (14%)
Query: 266 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY-----NNEKAEREVKALAKLDHVNI 320
D+ + +IG G FG+ +H + + +K ++ N + + +E LAK+ H NI
Sbjct: 3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNI 62
Query: 321 VHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEK 380
V + +S E+ + L+I ME+CD G L Q I++
Sbjct: 63 VAFK--------------ESFEAEGH---------------LYIVMEYCDGGDLMQKIKQ 93
Query: 381 RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLK 440
++G+ + + L F Q+ GV++IH K+++HRD+K NIFL +VK+GDFG L
Sbjct: 94 QKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLS 153
Query: 441 ND-GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAEL--LHVCDTAFETSKFFTD 497
N GT Y+ PE + Y + D+++LG IL EL L A
Sbjct: 154 NPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILK 213
Query: 498 LRDGIISDI---FDKKEKTLLQKLLSKKPEDRPNTSEIL 533
+ G IS + + + + L++++ + P RP+ + +L
Sbjct: 214 VCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLL 252
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 105 bits (261), Expect = 1e-22
Identities = 74/293 (25%), Positives = 139/293 (47%), Gaps = 45/293 (15%)
Query: 255 TKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-------EKAER 307
++ VD G + +++G GGF + ++ + K Y K + ++ EK ++
Sbjct: 70 SRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDK 129
Query: 308 EVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQME 367
E++ L H ++V + ++ D EN ++I +E
Sbjct: 130 EIELHRILHHKHVVQFYHYFE------------------DKEN-----------IYILLE 160
Query: 368 FCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQ 427
+C + ++ ++ R+ L + QI G+ Y+H ++++HRDLK N F+ + +
Sbjct: 161 YCSRRSMAHILKARK--VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAME 218
Query: 428 VKIGDFGLVTSLKN-DGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL---- 482
+K+GDFGL L+ + +R GT Y+SPE ++ Q +G E D++ALG ++ +L
Sbjct: 219 LKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRP 278
Query: 483 -HVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
ET + + R + S + K L+ +LSK PEDRP+ +I+R
Sbjct: 279 PFETTNLKETYRCIREARYTMPSSLL-APAKHLIASMLSKNPEDRPSLDDIIR 330
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 104 bits (259), Expect = 2e-22
Identities = 87/303 (28%), Positives = 141/303 (46%), Gaps = 45/303 (14%)
Query: 244 APRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK---- 299
AP P + + VD R + +G GGF + F+ + + K V
Sbjct: 30 APAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLL 89
Query: 300 ---YNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSR 356
+ EK E+ L H ++V ++G ++ D+
Sbjct: 90 LKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDF------------------------ 125
Query: 357 SKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLK 416
+F+ +E C + +L + + KRR + L + A QI G Y+H ++IHRDLK
Sbjct: 126 -----VFVVLELCRRRSLLE-LHKRR-KALTEPEARYYLRQIVLGCQYLHRNRVIHRDLK 178
Query: 417 PSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSK-GTLRYMSPEQISSQDYGKEVDLYALG 475
N+FL + +VKIGDFGL T ++ DG+R ++ GT Y++PE +S + + EVD++++G
Sbjct: 179 LGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIG 238
Query: 476 LILAELLHVCDTAFETSKF-FTDLR----DGIISDIFDKKEKTLLQKLLSKKPEDRPNTS 530
I+ LL V FETS T LR + I + +L+QK+L P RP +
Sbjct: 239 CIMYTLL-VGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIN 297
Query: 531 EIL 533
E+L
Sbjct: 298 ELL 300
>gi|197245437 eukaryotic translation initiation factor 2-alpha
kinase 1 isoform b [Homo sapiens]
Length = 629
Score = 103 bits (258), Expect = 3e-22
Identities = 75/230 (32%), Positives = 118/230 (51%), Gaps = 30/230 (13%)
Query: 335 ETSDDSLESSDYDPENSKNSSRSKTKC-LFIQMEFCDKGTLEQWI---EKRRGEKLDKV- 389
E S S E S + N + ++ L IQM+ C+ +L WI KR E +D+
Sbjct: 351 EESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESA 409
Query: 390 -------LALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS--- 438
+A ++F+++ +GV YIH+ ++HRDLKP NIFL +QVKIGDFGL +
Sbjct: 410 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 469
Query: 439 ------LKNDGKRTRSK----GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTA 488
+GKRT + GT Y SPEQ+ +Y + D+Y+LG++L EL T
Sbjct: 470 QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTE 529
Query: 489 FETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPEDRPNTSEILRT 535
E ++ T LR G + + K+ + +Q L + RP+ ++L++
Sbjct: 530 MERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQS 579
Score = 60.5 bits (145), Expect = 4e-09
Identities = 28/72 (38%), Positives = 45/72 (62%), Gaps = 6/72 (8%)
Query: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE------KAEREVKALAKL 315
R+ +F+E+ ++G GG+G+V+K ++++DG+ Y IK++ K REVK LA L
Sbjct: 162 RYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGL 221
Query: 316 DHVNIVHYNGCW 327
H NIV Y+ W
Sbjct: 222 QHPNIVGYHTAW 233
>gi|11125768 eukaryotic translation initiation factor 2-alpha kinase
1 isoform a [Homo sapiens]
Length = 630
Score = 103 bits (258), Expect = 3e-22
Identities = 75/230 (32%), Positives = 118/230 (51%), Gaps = 30/230 (13%)
Query: 335 ETSDDSLESSDYDPENSKNSSRSKTKC-LFIQMEFCDKGTLEQWI---EKRRGEKLDKV- 389
E S S E S + N + ++ L IQM+ C+ +L WI KR E +D+
Sbjct: 352 EESFTSTEESSEENVNFLGQTEAQYHLMLHIQMQLCEL-SLWDWIVERNKRGREYVDESA 410
Query: 390 -------LALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDT-KQVKIGDFGLVTS--- 438
+A ++F+++ +GV YIH+ ++HRDLKP NIFL +QVKIGDFGL +
Sbjct: 411 CPYVMANVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDIL 470
Query: 439 ------LKNDGKRTRSK----GTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTA 488
+GKRT + GT Y SPEQ+ +Y + D+Y+LG++L EL T
Sbjct: 471 QKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTE 530
Query: 489 FETSKFFTDLRDGIISDIFDKK---EKTLLQKLLSKKPEDRPNTSEILRT 535
E ++ T LR G + + K+ + +Q L + RP+ ++L++
Sbjct: 531 MERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQS 580
Score = 60.5 bits (145), Expect = 4e-09
Identities = 28/72 (38%), Positives = 45/72 (62%), Gaps = 6/72 (8%)
Query: 262 RFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE------KAEREVKALAKL 315
R+ +F+E+ ++G GG+G+V+K ++++DG+ Y IK++ K REVK LA L
Sbjct: 162 RYLNEFEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGL 221
Query: 316 DHVNIVHYNGCW 327
H NIV Y+ W
Sbjct: 222 QHPNIVGYHTAW 233
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 103 bits (257), Expect = 4e-22
Identities = 76/284 (26%), Positives = 134/284 (47%), Gaps = 39/284 (13%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE---REVKALAKLDHV-NIVH 322
F+ +EL+G+G +GQV+K +H G+ IK + ++ E +E+ L K H NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 84
Query: 323 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 382
Y G + +P DD L ++ MEFC G++ I+ +
Sbjct: 85 YYGAF--IKKNPPGMDDQL---------------------WLVMEFCGAGSVTDLIKNTK 121
Query: 383 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL-KN 441
G L + + +I +G+ ++H K+IHRD+K N+ L + +VK+ DFG+ L +
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 442 DGKRTRSKGTLRYMSPEQISSQD-----YGKEVDLYALGLILAELLH----VCDTAFETS 492
G+R GT +M+PE I+ + Y + DL++LG+ E+ +CD +
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 493 KFFTDLRDG--IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
F + S + KK ++ ++ L K RP T ++++
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMK 285
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 103 bits (257), Expect = 4e-22
Identities = 76/284 (26%), Positives = 134/284 (47%), Gaps = 39/284 (13%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE---REVKALAKLDHV-NIVH 322
F+ +EL+G+G +GQV+K +H G+ IK + ++ E +E+ L K H NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 84
Query: 323 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 382
Y G + +P DD L ++ MEFC G++ I+ +
Sbjct: 85 YYGAF--IKKNPPGMDDQL---------------------WLVMEFCGAGSVTDLIKNTK 121
Query: 383 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL-KN 441
G L + + +I +G+ ++H K+IHRD+K N+ L + +VK+ DFG+ L +
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 442 DGKRTRSKGTLRYMSPEQISSQD-----YGKEVDLYALGLILAELLH----VCDTAFETS 492
G+R GT +M+PE I+ + Y + DL++LG+ E+ +CD +
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 493 KFFTDLRDG--IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
F + S + KK ++ ++ L K RP T ++++
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMK 285
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 103 bits (257), Expect = 4e-22
Identities = 76/284 (26%), Positives = 134/284 (47%), Gaps = 39/284 (13%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE---REVKALAKLDHV-NIVH 322
F+ +EL+G+G +GQV+K +H G+ IK + ++ E +E+ L K H NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 84
Query: 323 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 382
Y G + +P DD L ++ MEFC G++ I+ +
Sbjct: 85 YYGAF--IKKNPPGMDDQL---------------------WLVMEFCGAGSVTDLIKNTK 121
Query: 383 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL-KN 441
G L + + +I +G+ ++H K+IHRD+K N+ L + +VK+ DFG+ L +
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 442 DGKRTRSKGTLRYMSPEQISSQD-----YGKEVDLYALGLILAELLH----VCDTAFETS 492
G+R GT +M+PE I+ + Y + DL++LG+ E+ +CD +
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 493 KFFTDLRDG--IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
F + S + KK ++ ++ L K RP T ++++
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMK 285
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 103 bits (257), Expect = 4e-22
Identities = 76/284 (26%), Positives = 134/284 (47%), Gaps = 39/284 (13%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE---REVKALAKLDHV-NIVH 322
F+ +EL+G+G +GQV+K +H G+ IK + ++ E +E+ L K H NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 84
Query: 323 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 382
Y G + +P DD L ++ MEFC G++ I+ +
Sbjct: 85 YYGAF--IKKNPPGMDDQL---------------------WLVMEFCGAGSVTDLIKNTK 121
Query: 383 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL-KN 441
G L + + +I +G+ ++H K+IHRD+K N+ L + +VK+ DFG+ L +
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 442 DGKRTRSKGTLRYMSPEQISSQD-----YGKEVDLYALGLILAELLH----VCDTAFETS 492
G+R GT +M+PE I+ + Y + DL++LG+ E+ +CD +
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 493 KFFTDLRDG--IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
F + S + KK ++ ++ L K RP T ++++
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMK 285
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 103 bits (257), Expect = 4e-22
Identities = 76/284 (26%), Positives = 134/284 (47%), Gaps = 39/284 (13%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE---REVKALAKLDHV-NIVH 322
F+ +EL+G+G +GQV+K +H G+ IK + ++ E +E+ L K H NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 84
Query: 323 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 382
Y G + +P DD L ++ MEFC G++ I+ +
Sbjct: 85 YYGAF--IKKNPPGMDDQL---------------------WLVMEFCGAGSVTDLIKNTK 121
Query: 383 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL-KN 441
G L + + +I +G+ ++H K+IHRD+K N+ L + +VK+ DFG+ L +
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 442 DGKRTRSKGTLRYMSPEQISSQD-----YGKEVDLYALGLILAELLH----VCDTAFETS 492
G+R GT +M+PE I+ + Y + DL++LG+ E+ +CD +
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 493 KFFTDLRDG--IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
F + S + KK ++ ++ L K RP T ++++
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMK 285
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 103 bits (257), Expect = 4e-22
Identities = 76/284 (26%), Positives = 134/284 (47%), Gaps = 39/284 (13%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE---REVKALAKLDHV-NIVH 322
F+ +EL+G+G +GQV+K +H G+ IK + ++ E +E+ L K H NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 84
Query: 323 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 382
Y G + +P DD L ++ MEFC G++ I+ +
Sbjct: 85 YYGAF--IKKNPPGMDDQL---------------------WLVMEFCGAGSVTDLIKNTK 121
Query: 383 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL-KN 441
G L + + +I +G+ ++H K+IHRD+K N+ L + +VK+ DFG+ L +
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 442 DGKRTRSKGTLRYMSPEQISSQD-----YGKEVDLYALGLILAELLH----VCDTAFETS 492
G+R GT +M+PE I+ + Y + DL++LG+ E+ +CD +
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 493 KFFTDLRDG--IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
F + S + KK ++ ++ L K RP T ++++
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMK 285
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 103 bits (257), Expect = 4e-22
Identities = 76/284 (26%), Positives = 134/284 (47%), Gaps = 39/284 (13%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE---REVKALAKLDHV-NIVH 322
F+ +EL+G+G +GQV+K +H G+ IK + ++ E +E+ L K H NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 84
Query: 323 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 382
Y G + +P DD L ++ MEFC G++ I+ +
Sbjct: 85 YYGAF--IKKNPPGMDDQL---------------------WLVMEFCGAGSVTDLIKNTK 121
Query: 383 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL-KN 441
G L + + +I +G+ ++H K+IHRD+K N+ L + +VK+ DFG+ L +
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 442 DGKRTRSKGTLRYMSPEQISSQD-----YGKEVDLYALGLILAELLH----VCDTAFETS 492
G+R GT +M+PE I+ + Y + DL++LG+ E+ +CD +
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 493 KFFTDLRDG--IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
F + S + KK ++ ++ L K RP T ++++
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMK 285
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 103 bits (257), Expect = 4e-22
Identities = 76/284 (26%), Positives = 134/284 (47%), Gaps = 39/284 (13%)
Query: 267 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE---REVKALAKLDHV-NIVH 322
F+ +EL+G+G +GQV+K +H G+ IK + ++ E +E+ L K H NI
Sbjct: 25 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 84
Query: 323 YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRR 382
Y G + +P DD L ++ MEFC G++ I+ +
Sbjct: 85 YYGAF--IKKNPPGMDDQL---------------------WLVMEFCGAGSVTDLIKNTK 121
Query: 383 GEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSL-KN 441
G L + + +I +G+ ++H K+IHRD+K N+ L + +VK+ DFG+ L +
Sbjct: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
Query: 442 DGKRTRSKGTLRYMSPEQISSQD-----YGKEVDLYALGLILAELLH----VCDTAFETS 492
G+R GT +M+PE I+ + Y + DL++LG+ E+ +CD +
Sbjct: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
Query: 493 KFFTDLRDG--IISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
F + S + KK ++ ++ L K RP T ++++
Sbjct: 242 LFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMK 285
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 100 bits (250), Expect = 3e-21
Identities = 80/300 (26%), Positives = 135/300 (45%), Gaps = 47/300 (15%)
Query: 249 LPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK-------YN 301
LP + D R G + + L+G GGF + ++A G Y +K + +
Sbjct: 44 LPTSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQ 103
Query: 302 NEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKC 361
EK E++ L H +IV ++ ++ D +N
Sbjct: 104 REKILNEIELHRDLQHRHIVRFSHHFE------------------DADN----------- 134
Query: 362 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 421
++I +E C + +L I K R L+ + L QI G+ Y+H + ++HRDLK N F
Sbjct: 135 IYIFLELCSRKSLAH-IWKARHTLLEPEVRYYL-RQILSGLKYLHQRGILHRDLKLGNFF 192
Query: 422 LVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLILAE 480
+ + ++K+GDFGL L+ +R ++ GT Y++PE + Q +G E D+++LG ++
Sbjct: 193 ITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYT 252
Query: 481 LLHVCDT-AFETSKFFTDLR-----DGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 534
LL C + FET+ R + + LL +L P DRP+ +ILR
Sbjct: 253 LL--CGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILR 310
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 99.8 bits (247), Expect = 6e-21
Identities = 83/321 (25%), Positives = 144/321 (44%), Gaps = 63/321 (19%)
Query: 250 PDMKETKYTVDKRFGM-DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY-------N 301
PD + T+ R + DF+ + IG G F +V+KA +D KT +K+V+
Sbjct: 61 PDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKA 120
Query: 302 NEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKC 361
+ +E+ L +L+H NI+ Y D F D E
Sbjct: 121 RQDCVKEIGLLKQLNHPNIIKY---LDSFIEDNE-------------------------- 151
Query: 362 LFIQMEFCDKGTLEQWIE--KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSN 419
L I +E D G L Q I+ K++ + + + F Q+ V+++HS++++HRD+KP+N
Sbjct: 152 LNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPAN 211
Query: 420 IFLVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLIL 478
+F+ T VK+GD GL ++ S GT YMSPE+I Y + D+++LG +L
Sbjct: 212 VFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLL 271
Query: 479 AELLHVCDTAFETSKFFTDLRD--------------GIISDIFDKKEKTLLQKLLSKKPE 524
E+ A S F+ D + + + + +K + L+ + P
Sbjct: 272 YEM------AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPH 325
Query: 525 DRPN---TSEILRTLTVWKKS 542
RP+ ++ + + +W S
Sbjct: 326 QRPDIGYVHQVAKQMHIWMSS 346
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 99.8 bits (247), Expect = 6e-21
Identities = 83/321 (25%), Positives = 144/321 (44%), Gaps = 63/321 (19%)
Query: 250 PDMKETKYTVDKRFGM-DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY-------N 301
PD + T+ R + DF+ + IG G F +V+KA +D KT +K+V+
Sbjct: 27 PDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKA 86
Query: 302 NEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKC 361
+ +E+ L +L+H NI+ Y D F D E
Sbjct: 87 RQDCVKEIGLLKQLNHPNIIKY---LDSFIEDNE-------------------------- 117
Query: 362 LFIQMEFCDKGTLEQWIE--KRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSN 419
L I +E D G L Q I+ K++ + + + F Q+ V+++HS++++HRD+KP+N
Sbjct: 118 LNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPAN 177
Query: 420 IFLVDTKQVKIGDFGLVTSLKNDGKRTRS-KGTLRYMSPEQISSQDYGKEVDLYALGLIL 478
+F+ T VK+GD GL ++ S GT YMSPE+I Y + D+++LG +L
Sbjct: 178 VFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLL 237
Query: 479 AELLHVCDTAFETSKFFTDLRD--------------GIISDIFDKKEKTLLQKLLSKKPE 524
E+ A S F+ D + + + + +K + L+ + P
Sbjct: 238 YEM------AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPH 291
Query: 525 DRPN---TSEILRTLTVWKKS 542
RP+ ++ + + +W S
Sbjct: 292 QRPDIGYVHQVAKQMHIWMSS 312
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 98.6 bits (244), Expect = 1e-20
Identities = 75/272 (27%), Positives = 128/272 (47%), Gaps = 47/272 (17%)
Query: 270 IELIGSGGFGQVFKAKHRIDGKTYVIKRVK----YNNEKAEREVKALAKLDHVNIVHYNG 325
+E++GSG F +VF K R+ GK + +K +K + + E E+ L K+ H NIV
Sbjct: 26 MEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIV---- 81
Query: 326 CWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEK 385
T +D ES+ + ++ M+ G L I RG
Sbjct: 82 ----------TLEDIYESTTH---------------YYLVMQLVSGGELFDRI-LERGVY 115
Query: 386 LDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV---DTKQVKIGDFGLVTSLKND 442
+K +L + +Q+ V Y+H ++HRDLKP N+ + + ++ I DFGL + ++ +
Sbjct: 116 TEKDASL-VIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGL-SKMEQN 173
Query: 443 GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFE--TSKFFTDLRD 500
G + + GT Y++PE ++ + Y K VD +++G+I LL +E SK F +++
Sbjct: 174 GIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKE 233
Query: 501 GIIS------DIFDKKEKTLLQKLLSKKPEDR 526
G D + K + LL K P +R
Sbjct: 234 GYYEFESPFWDDISESAKDFICHLLEKDPNER 265
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 97.4 bits (241), Expect = 3e-20
Identities = 83/304 (27%), Positives = 132/304 (43%), Gaps = 61/304 (20%)
Query: 249 LPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN------ 302
LP M+ K ++ F ++E IG G FG+VFK ID +T + +K +
Sbjct: 10 LPGMQNLKADPEELF----TKLEKIGKGSFGEVFKG---IDNRTQKVVAIKIIDLEEAED 62
Query: 303 --EKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK 360
E ++E+ L++ D + Y G S K
Sbjct: 63 EIEDIQQEITVLSQCDSPYVTKYYG-----------------------------SYLKDT 93
Query: 361 CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI 420
L+I ME+ G+ +E LD+ + +I KG+DY+HS+K IHRD+K +N+
Sbjct: 94 KLWIIMEYLGGGSALDLLEPG---PLDETQIATILREILKGLDYLHSEKKIHRDIKAANV 150
Query: 421 FLVDTKQVKIGDFGLVTSLKNDG-KRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILA 479
L + +VK+ DFG+ L + KR GT +M+PE I Y + D+++LG+
Sbjct: 151 LLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAI 210
Query: 480 EL---------LHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTS 530
EL LH F K +G + K K ++ L+K+P RP
Sbjct: 211 ELARGEPPHSELHPMKVLFLIPKNNPPTLEG----NYSKPLKEFVEACLNKEPSFRPTAK 266
Query: 531 EILR 534
E+L+
Sbjct: 267 ELLK 270
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,529,578
Number of Sequences: 37866
Number of extensions: 833751
Number of successful extensions: 4808
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 735
Number of HSP's successfully gapped in prelim test: 132
Number of HSP's that attempted gapping in prelim test: 2471
Number of HSP's gapped (non-prelim): 1570
length of query: 551
length of database: 18,247,518
effective HSP length: 107
effective length of query: 444
effective length of database: 14,195,856
effective search space: 6302960064
effective search space used: 6302960064
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.