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Search of human proteins with 4505815
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505815 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 2 [Homo sapiens]
(549 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505815 phosphatidylinositol-4-phosphate 5-kinase, type I, al... 1103 0.0
gi|208431778 phosphatidylinositol-4-phosphate 5-kinase, type I, ... 1089 0.0
gi|208431774 phosphatidylinositol-4-phosphate 5-kinase, type I, ... 1026 0.0
gi|208431776 phosphatidylinositol-4-phosphate 5-kinase, type I, ... 981 0.0
gi|31317309 phosphatidylinositol-4-phosphate 5-kinase, type I, g... 677 0.0
gi|4505817 phosphatidylinositol-4-phosphate 5-kinase, type I, be... 603 e-172
gi|4505819 phosphatidylinositol-5-phosphate 4-kinase, type II, b... 170 3e-42
gi|6857820 phosphatidylinositol-5-phosphate 4-kinase, type II, a... 164 3e-40
gi|226371739 phosphatidylinositol-5-phosphate 4-kinase, type II,... 163 4e-40
gi|226371737 phosphatidylinositol-5-phosphate 4-kinase, type II,... 163 4e-40
gi|226371741 phosphatidylinositol-5-phosphate 4-kinase, type II,... 156 4e-38
gi|226371743 phosphatidylinositol-5-phosphate 4-kinase, type II,... 132 6e-31
gi|206725454 phosphatidylinositol-4-phosphate 5-kinase-like 1 is... 104 2e-22
gi|27735085 phosphatidylinositol-4-phosphate 5-kinase-like 1 iso... 54 3e-07
gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III ... 53 8e-07
gi|18105056 vacuolar protein sorting 33A [Homo sapiens] 34 0.40
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 33 0.52
gi|157168329 formin 1 [Homo sapiens] 33 0.88
gi|222537754 hypothetical protein LOC375337 [Homo sapiens] 32 1.2
gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens] 32 1.5
gi|221139926 NHS-like 1 [Homo sapiens] 31 2.6
gi|193083221 mast cell immunoreceptor signal transducer [Homo sa... 30 4.4
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 30 5.7
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 30 5.7
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 30 5.7
gi|58530863 melanoma antigen family A, 10 [Homo sapiens] 30 7.5
gi|10567820 melanoma antigen family A, 10 [Homo sapiens] 30 7.5
gi|4504425 high-mobility group box 1 [Homo sapiens] 29 9.8
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 29 9.8
gi|14277690 hypothetical protein LOC9750 isoform 2 [Homo sapiens] 29 9.8
>gi|4505815 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
isoform 2 [Homo sapiens]
Length = 549
Score = 1103 bits (2852), Expect = 0.0
Identities = 549/549 (100%), Positives = 549/549 (100%)
Query: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYASGMPIKKIGHRSVDSSG 60
MASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYASGMPIKKIGHRSVDSSG
Sbjct: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYASGMPIKKIGHRSVDSSG 60
Query: 61 ETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHH 120
ETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHH
Sbjct: 61 ETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHH 120
Query: 121 YNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFII 180
YNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFII
Sbjct: 121 YNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFII 180
Query: 181 KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVK 240
KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVK
Sbjct: 181 KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVK 240
Query: 241 MHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCL 300
MHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCL
Sbjct: 241 MHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCL 300
Query: 301 VLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARR 360
VLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARR
Sbjct: 301 VLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARR 360
Query: 361 GGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHR 420
GGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHR
Sbjct: 361 GGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHR 420
Query: 421 PGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKA 480
PGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKA
Sbjct: 421 PGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKA 480
Query: 481 QVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKL 540
QVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKL
Sbjct: 481 QVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKL 540
Query: 541 EVAESEFTH 549
EVAESEFTH
Sbjct: 541 EVAESEFTH 549
>gi|208431778 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 1 [Homo sapiens]
Length = 562
Score = 1089 bits (2817), Expect = 0.0
Identities = 549/562 (97%), Positives = 549/562 (97%), Gaps = 13/562 (2%)
Query: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSA-SGIKRPMASEV------------PYASGMP 47
MASASSGPSSSVGFSSFDPAVPSCTLSSA SGIKRPMASEV PYASGMP
Sbjct: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMP 60
Query: 48 IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF 107
IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF
Sbjct: 61 IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF 120
Query: 108 FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG 167
FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG
Sbjct: 121 FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG 180
Query: 168 SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR 227
SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR
Sbjct: 181 SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR 240
Query: 228 IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM 287
IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM
Sbjct: 241 IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM 300
Query: 288 YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY 347
YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY
Sbjct: 301 YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY 360
Query: 348 STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWK 407
STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWK
Sbjct: 361 STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWK 420
Query: 408 ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC 467
ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC
Sbjct: 421 ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC 480
Query: 468 ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET 527
ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET
Sbjct: 481 ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET 540
Query: 528 LQMLTTSTTLEKLEVAESEFTH 549
LQMLTTSTTLEKLEVAESEFTH
Sbjct: 541 LQMLTTSTTLEKLEVAESEFTH 562
>gi|208431774 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 3 [Homo sapiens]
Length = 522
Score = 1026 bits (2654), Expect = 0.0
Identities = 520/550 (94%), Positives = 521/550 (94%), Gaps = 29/550 (5%)
Query: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSA-SGIKRPMASEVPYASGMPIKKIGHRSVDSS 59
MASASSGPSSSVGFSSFDPAVPSCTLSSA SGIKRPMASEVPYASGMPIKKIGHRSVDSS
Sbjct: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVPYASGMPIKKIGHRSVDSS 60
Query: 60 GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH 119
GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH
Sbjct: 61 GETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAH 120
Query: 120 HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI 179
HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI
Sbjct: 121 HYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFI 180
Query: 180 IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV 239
IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV
Sbjct: 181 IKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSV 240
Query: 240 KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC 299
KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC
Sbjct: 241 KMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDC 300
Query: 300 LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR 359
LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR
Sbjct: 301 LVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEAR 360
Query: 360 RGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVH 419
RGGTMETDD +FVKKLEHSWKALVHDGDTVSVH
Sbjct: 361 RGGTMETDD----------------------------QFVKKLEHSWKALVHDGDTVSVH 392
Query: 420 RPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHK 479
RPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHK
Sbjct: 393 RPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHK 452
Query: 480 AQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEK 539
AQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEK
Sbjct: 453 AQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEK 512
Query: 540 LEVAESEFTH 549
LEVAESEFTH
Sbjct: 513 LEVAESEFTH 522
>gi|208431776 phosphatidylinositol-4-phosphate 5-kinase, type I,
alpha isoform 4 [Homo sapiens]
Length = 500
Score = 981 bits (2535), Expect = 0.0
Identities = 499/549 (90%), Positives = 499/549 (90%), Gaps = 49/549 (8%)
Query: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYASGMPIKKIGHRSVDSSG 60
MASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYASGMPIKKIGHRSVDSSG
Sbjct: 1 MASASSGPSSSVGFSSFDPAVPSCTLSSASGIKRPMASEVPYASGMPIKKIGHRSVDSSG 60
Query: 61 ETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHH 120
ETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHH
Sbjct: 61 ETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHH 120
Query: 121 YNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFII 180
YNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFII
Sbjct: 121 YNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFII 180
Query: 181 KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVK 240
KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVK
Sbjct: 181 KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVK 240
Query: 241 MHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCL 300
MHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCL
Sbjct: 241 MHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCL 300
Query: 301 VLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARR 360
VLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARR
Sbjct: 301 VLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARR 360
Query: 361 GGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHR 420
GGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHR
Sbjct: 361 GGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHR 420
Query: 421 PGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKA 480
PGFYAERFQRFMCNTVFKKIP
Sbjct: 421 PGFYAERFQRFMCNTVFKKIPC-------------------------------------- 442
Query: 481 QVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKL 540
VHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKL
Sbjct: 443 -----------VHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKL 491
Query: 541 EVAESEFTH 549
EVAESEFTH
Sbjct: 492 EVAESEFTH 500
>gi|31317309 phosphatidylinositol-4-phosphate 5-kinase, type I,
gamma [Homo sapiens]
Length = 668
Score = 677 bits (1748), Expect = 0.0
Identities = 343/468 (73%), Positives = 388/468 (82%), Gaps = 3/468 (0%)
Query: 49 KKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFF 108
KK+GHR VD+SGETTYKKTTSS LKGAIQLGI +TVG LS+KPERDVLMQDFYVVESIFF
Sbjct: 56 KKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFF 115
Query: 109 PSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGS 168
PSEGSNLTPAHH+ DFRFKTYAPVAFRYFRELFGIRPDDYLYSLC+EPLIEL + GASGS
Sbjct: 116 PSEGSNLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGS 175
Query: 169 LFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRI 228
LFYV+SDDEFIIKTV HKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQ+GGKNIR+
Sbjct: 176 LFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRV 235
Query: 229 VVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMY 288
VVMNN+LPR VKMH+K+DLKGSTYKRRAS+KE+EK PT+KDLDF+QD+P+GL LDAD +
Sbjct: 236 VVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTF 295
Query: 289 NALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYS 348
+AL KTLQRDCLVL+SFKIMDYSLL+ +HNID +RE + Q + D +RP QKALYS
Sbjct: 296 SALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYS 355
Query: 349 TAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKA 408
TAMESIQG A RG +E+DD MGGIPA N +GERLLL+IGIIDILQSYRF+KKLEH+WKA
Sbjct: 356 TAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKA 415
Query: 409 LVHDGDTVSVHRPGFYAERFQRFMCNTVFKK-IPLKPSPSKKFRSGSSFS-RRAGSSGNS 466
LVHDGDTVSVHRP FYAERF +FM NTVF+K LK SPSKK R G+ + + G +
Sbjct: 416 LVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAF 475
Query: 467 CITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPP-LEEISEGS 513
+ PS E + + GRPD+LP TPP EE + S
Sbjct: 476 SASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPSFEEATTAS 523
>gi|4505817 phosphatidylinositol-4-phosphate 5-kinase, type I, beta
isoform 2 [Homo sapiens]
Length = 540
Score = 603 bits (1556), Expect = e-172
Identities = 315/460 (68%), Positives = 363/460 (78%), Gaps = 18/460 (3%)
Query: 61 ETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHH 120
E TYKKT SSA+KGAIQLGI +TVG+L++KPERDVLMQDFYVVES+F PSEGSNLTPAHH
Sbjct: 18 EKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHH 77
Query: 121 YNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFII 180
Y DFRFKTYAP+AFRYFRELFGI+PDDYLYS+CSEPLIEL + GASGSLF+V+SDDEFII
Sbjct: 78 YPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFVTSDDEFII 137
Query: 181 KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVK 240
KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYC+Q+GG NIRIVVMNN+LPRS++
Sbjct: 138 KTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRSMR 197
Query: 241 MHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCL 300
MH YDLKGSTYKRRAS+KEREK PTFKDLDFLQD+ +GL+ D + YNAL KTLQRDC
Sbjct: 198 MHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCR 257
Query: 301 VLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQGEARR 360
VL+SFKIMDYSLL+ IH +DH+ +E Q D +R QK LYSTAMESIQG +
Sbjct: 258 VLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQKVLYSTAMESIQGPGKS 317
Query: 361 GGTM--ETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSV 418
G + E D MGGIPA++ +GE+LLL++GIIDILQSYR +KKLEHSWKALV+DGDTVSV
Sbjct: 318 GDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSV 377
Query: 419 HRPGFYAERFQRFMCNTVFKKI-PLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGE 477
HRP FYA+RF +FM + VFKKI LK SPSKK R S + +A S S+S E
Sbjct: 378 HRPSFYADRFLKFMNSRVFKKIQALKASPSKK-RCNSIAALKATSQ-----EIVSSISQE 431
Query: 478 HK---------AQVTTKAEVEPGVHLGRPDVLPQTPPLEE 508
K Q + + E RPD++P TP L E
Sbjct: 432 WKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFE 471
>gi|4505819 phosphatidylinositol-5-phosphate 4-kinase, type II, beta
[Homo sapiens]
Length = 416
Score = 170 bits (431), Expect = 3e-42
Identities = 125/383 (32%), Positives = 185/383 (48%), Gaps = 25/383 (6%)
Query: 69 SSALKGAIQLGITHTVGSLSTKPERDVLMQDFYV------VESIFFPSEGSNLTPAHHYN 122
S + + G+ HT+ LS P +LM D + V++ F E NL +
Sbjct: 39 SEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKE--NLP-----S 91
Query: 123 DFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKT 182
F+FK Y P+ FR RE FGI DY S+ I S G G+ F + D F+IKT
Sbjct: 92 RFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKT 151
Query: 183 VQHKEAEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKM 241
V ++ + +L Y+ + + + TLLP+F G+Y + G +VV N+ + +
Sbjct: 152 VSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTV 211
Query: 242 HIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLV 301
H KYDLKGST R AS KE+ K LPTFKD DFL + L + + + L+RD
Sbjct: 212 HRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNE-GQKLHVGEESKKNFLEKLKRDVEF 270
Query: 302 LQSFKIMDYSLLMSIHNIDHAQREPLS----SETQYSVDTRRPAPQKALYSTAMES---I 354
L KIMDYSLL+ IH++D A++E + +E + + Y T +S +
Sbjct: 271 LAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNL 330
Query: 355 QGEARRGGTMETDDHMG--GIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHD 412
R G E D + + + S ++ + ++ IIDIL Y KK H+ K + H
Sbjct: 331 LSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHG 390
Query: 413 -GDTVSVHRPGFYAERFQRFMCN 434
G +S P Y++RF FM N
Sbjct: 391 AGAEISTVNPEQYSKRFNEFMSN 413
>gi|6857820 phosphatidylinositol-5-phosphate 4-kinase, type II,
alpha [Homo sapiens]
Length = 406
Score = 164 bits (414), Expect = 3e-40
Identities = 115/383 (30%), Positives = 185/383 (48%), Gaps = 34/383 (8%)
Query: 69 SSALKGAIQLGITHTVGSLSTKPERDVLMQDFYV------VESIFFPSEGSNLTPAHHYN 122
S L + G+ H++ LS +LM D + V++ F E P+H
Sbjct: 34 SDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENM---PSH--- 87
Query: 123 DFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKT 182
F+FK Y P+ FR RE FGI D+ SL + S SG+ F+ S D +IIKT
Sbjct: 88 -FKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKT 146
Query: 183 VQHKEAEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKM 241
+ ++ + +L Y+ + + + TLLP+F G+Y + G I ++V N+ + +
Sbjct: 147 ITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSV 206
Query: 242 HIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLV 301
+ KYDLKGST R AS KE+ K LPT KD DF+ + +++D + + L++D
Sbjct: 207 YRKYDLKGSTVAREASDKEKAKELPTLKDNDFINE-GQKIYIDDNNKKVFLEKLKKDVEF 265
Query: 302 LQSFKIMDYSLLMSIHNIDHAQREPL-----------SSETQYSVDTRRPAPQKALYSTA 350
L K+MDYSLL+ IH+++ A++E + S+ + V T +P L S+
Sbjct: 266 LAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSS- 324
Query: 351 MESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALV 410
G + + + GI + + + ++ IIDIL Y KK H+ K +
Sbjct: 325 ------PPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVK 378
Query: 411 HD-GDTVSVHRPGFYAERFQRFM 432
H G +S P Y++RF F+
Sbjct: 379 HGAGAEISTVNPEQYSKRFLDFI 401
>gi|226371739 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform a [Homo sapiens]
Length = 421
Score = 163 bits (412), Expect = 4e-40
Identities = 125/381 (32%), Positives = 182/381 (47%), Gaps = 27/381 (7%)
Query: 72 LKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEG----SNLTPAHHYNDFRFK 127
L G G+ H++ LS P +L+ D + S + NL P+H F+FK
Sbjct: 47 LVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL-PSH----FKFK 101
Query: 128 TYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKE 187
Y P FR R+ FGI DYL SL P E S G+ G F +S D +IK V ++
Sbjct: 102 EYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSED 158
Query: 188 AEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYD 246
+ L Y+ + + + TLLP+F G+Y V ++ ++VM N+ + +H KYD
Sbjct: 159 IADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD 218
Query: 247 LKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFK 306
LKGS R AS KE+ K LPT KD+DFL +++ + + L+RD L K
Sbjct: 219 LKGSLVSREASDKEKVKELPTLKDMDFLNK-NQKVYIGEEEKKIFLEKLKRDVEFLVQLK 277
Query: 307 IMDYSLLMSIHNI-------DHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQG--- 356
IMDYSLL+ IH+I + A SE P Y T+ E I G
Sbjct: 278 IMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIH 337
Query: 357 EARRGGTMETDDHMGGIPARNSKG--ERLLLYIGIIDILQSYRFVKKLEHSWKALVHD-G 413
R G E + + R+++G ++ + ++G+IDIL Y KK H+ K + H G
Sbjct: 338 SHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAG 397
Query: 414 DTVSVHRPGFYAERFQRFMCN 434
+S P YA+RF F+ N
Sbjct: 398 AEISTVHPEQYAKRFLDFITN 418
>gi|226371737 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform a [Homo sapiens]
Length = 421
Score = 163 bits (412), Expect = 4e-40
Identities = 125/381 (32%), Positives = 182/381 (47%), Gaps = 27/381 (7%)
Query: 72 LKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEG----SNLTPAHHYNDFRFK 127
L G G+ H++ LS P +L+ D + S + NL P+H F+FK
Sbjct: 47 LVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL-PSH----FKFK 101
Query: 128 TYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKE 187
Y P FR R+ FGI DYL SL P E S G+ G F +S D +IK V ++
Sbjct: 102 EYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSED 158
Query: 188 AEFLQKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYD 246
+ L Y+ + + + TLLP+F G+Y V ++ ++VM N+ + +H KYD
Sbjct: 159 IADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYD 218
Query: 247 LKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFK 306
LKGS R AS KE+ K LPT KD+DFL +++ + + L+RD L K
Sbjct: 219 LKGSLVSREASDKEKVKELPTLKDMDFLNK-NQKVYIGEEEKKIFLEKLKRDVEFLVQLK 277
Query: 307 IMDYSLLMSIHNI-------DHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQG--- 356
IMDYSLL+ IH+I + A SE P Y T+ E I G
Sbjct: 278 IMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIH 337
Query: 357 EARRGGTMETDDHMGGIPARNSKG--ERLLLYIGIIDILQSYRFVKKLEHSWKALVHD-G 413
R G E + + R+++G ++ + ++G+IDIL Y KK H+ K + H G
Sbjct: 338 SHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAG 397
Query: 414 DTVSVHRPGFYAERFQRFMCN 434
+S P YA+RF F+ N
Sbjct: 398 AEISTVHPEQYAKRFLDFITN 418
>gi|226371741 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform b [Homo sapiens]
Length = 403
Score = 156 bits (395), Expect = 4e-38
Identities = 119/377 (31%), Positives = 174/377 (46%), Gaps = 37/377 (9%)
Query: 72 LKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAP 131
L G G+ H++ LS P +L+ D + S + K Y P
Sbjct: 47 LVGVFLWGVAHSINELSQVPPPVMLLPDDFKASS-------------------KIKEYCP 87
Query: 132 VAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKEAEFL 191
FR R+ FGI DYL SL P E S G+ G F +S D +IK V ++ +
Sbjct: 88 QVFRNLRDRFGIDDQDYLVSLTRNPPSE--SEGSDGR-FLISYDRTLVIKEVSSEDIADM 144
Query: 192 QKLLPGYYMNLNQ-NPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDLKGS 250
L Y+ + + + TLLP+F G+Y V ++ ++VM N+ + +H KYDLKGS
Sbjct: 145 HSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGS 204
Query: 251 TYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDY 310
R AS KE+ K LPT KD+DFL +++ + + L+RD L KIMDY
Sbjct: 205 LVSREASDKEKVKELPTLKDMDFLNK-NQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDY 263
Query: 311 SLLMSIHNI-------DHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQG---EARR 360
SLL+ IH+I + A SE P Y T+ E I G R
Sbjct: 264 SLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRP 323
Query: 361 GGTMETDDHMGGIPARNSKG--ERLLLYIGIIDILQSYRFVKKLEHSWKALVHD-GDTVS 417
G E + + R+++G ++ + ++G+IDIL Y KK H+ K + H G +S
Sbjct: 324 LGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEIS 383
Query: 418 VHRPGFYAERFQRFMCN 434
P YA+RF F+ N
Sbjct: 384 TVHPEQYAKRFLDFITN 400
>gi|226371743 phosphatidylinositol-5-phosphate 4-kinase, type II,
gamma isoform c [Homo sapiens]
Length = 373
Score = 132 bits (333), Expect = 6e-31
Identities = 113/380 (29%), Positives = 162/380 (42%), Gaps = 73/380 (19%)
Query: 72 LKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEG----SNLTPAHHYNDFRFK 127
L G G+ H++ LS P +L+ D + S + NL P+H F+FK
Sbjct: 47 LVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENL-PSH----FKFK 101
Query: 128 TYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKTVQHKE 187
Y P FR R+ FGI DYLY I+K
Sbjct: 102 EYCPQVFRNLRDRFGIDDQDYLY----------------------------IVKC----- 128
Query: 188 AEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIRIVVMNNLLPRSVKMHIKYDL 247
+ TLLP+F G+Y V ++ ++VM N+ + +H KYDL
Sbjct: 129 -----------------HGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDL 171
Query: 248 KGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKI 307
KGS R AS KE+ K LPT KD+DFL +++ + + L+RD L KI
Sbjct: 172 KGSLVSREASDKEKVKELPTLKDMDFLNK-NQKVYIGEEEKKIFLEKLKRDVEFLVQLKI 230
Query: 308 MDYSLLMSIHNI-------DHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQG---E 357
MDYSLL+ IH+I + A SE P Y T+ E I G
Sbjct: 231 MDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHS 290
Query: 358 ARRGGTMETDDHMGGIPARNSKG--ERLLLYIGIIDILQSYRFVKKLEHSWKALVHD-GD 414
R G E + + R+++G ++ + ++G+IDIL Y KK H+ K + H G
Sbjct: 291 HRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGA 350
Query: 415 TVSVHRPGFYAERFQRFMCN 434
+S P YA+RF F+ N
Sbjct: 351 EISTVHPEQYAKRFLDFITN 370
>gi|206725454 phosphatidylinositol-4-phosphate 5-kinase-like 1
isoform 1 [Homo sapiens]
Length = 394
Score = 104 bits (259), Expect = 2e-22
Identities = 85/322 (26%), Positives = 143/322 (44%), Gaps = 34/322 (10%)
Query: 115 LTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLC-SEPLIELCSSGASGSLFYVS 173
LT H F T A AF + R G+ +DY +L P ++ S+ S + F++S
Sbjct: 88 LTQVHE--GFELGTLAGPAFAWLRRSLGLAEEDYQAALGPGGPYLQFLSTSKSKASFFLS 145
Query: 174 SDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAG-GKNIRIVVMN 232
D F +KT +E + L LP Y +L ++P +LL + G++ ++ GK +VM
Sbjct: 146 HDQRFFLKTQGRREVQALLAHLPRYVQHLQRHPHSLLARLLGVHSLRVDRGKKTYFIVMQ 205
Query: 233 NLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLP-TFKDLDFLQDIPDGLFLDADMYNA- 290
++ + ++ +YD+KG R PL KDL+F G ++ +
Sbjct: 206 SVFYPAGRISERYDIKGCEVSRWVDPAPEGSPLVLVLKDLNF-----QGKTINLGPQRSW 260
Query: 291 LCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTA 350
+ ++ D L+ ++DYSLL++ + +R P SS ++ TA
Sbjct: 261 FLRQMELDTTFLRELNVLDYSLLIAFQRLHEDERGPGSS---------------LIFRTA 305
Query: 351 MESIQG-----EARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHS 405
S+QG E+R D + + +R ++G++D+ Y K+LEH
Sbjct: 306 -RSVQGAQSPEESRAQNRRLLPDAPNALHILDGPEQR--YFLGVVDLATVYGLRKRLEHL 362
Query: 406 WKALVHDGDTVSVHRPGFYAER 427
WK L + G T S P YA R
Sbjct: 363 WKTLRYPGRTFSTVSPARYARR 384
>gi|27735085 phosphatidylinositol-4-phosphate 5-kinase-like 1
isoform 2 [Homo sapiens]
Length = 191
Score = 54.3 bits (129), Expect = 3e-07
Identities = 49/191 (25%), Positives = 79/191 (41%), Gaps = 30/191 (15%)
Query: 244 KYDLKGSTYKRRASQKEREKPLP-TFKDLDFLQDIPDGLFLDADMYNA-LCKTLQRDCLV 301
+YD+KG R PL KDL+F G ++ + + ++ D
Sbjct: 14 RYDIKGCEVSRWVDPAPEGSPLVLVLKDLNF-----QGKTINLGPQRSWFLRQMELDTTF 68
Query: 302 LQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALYSTAMESIQG----- 356
L+ ++DYSLL++ + +R P SS ++ TA S+QG
Sbjct: 69 LRELNVLDYSLLIAFQRLHEDERGPGSS---------------LIFRTA-RSVQGAQSPE 112
Query: 357 EARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTV 416
E+R D + + +R ++G++D+ Y K+LEH WK L + G T
Sbjct: 113 ESRAQNRRLLPDAPNALHILDGPEQRY--FLGVVDLATVYGLRKRLEHLWKTLRYPGRTF 170
Query: 417 SVHRPGFYAER 427
S P YA R
Sbjct: 171 STVSPARYARR 181
>gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III
isoform 2 [Homo sapiens]
Length = 2098
Score = 52.8 bits (125), Expect = 8e-07
Identities = 55/204 (26%), Positives = 86/204 (42%), Gaps = 15/204 (7%)
Query: 124 FRFKTYAPVAFRYFRE-LFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEFIIKT 182
F + Y F RE + +D++ SL + G SG+ FY + DD FI+K
Sbjct: 1820 FYCRLYYAGEFHKMREVILDSSEEDFIRSLSHSSPWQ-ARGGKSGAAFYATEDDRFILKQ 1878
Query: 183 VQHKEAEFLQKLLPGYYMNL----NQNPRTLLPKFYGLYCV------QAGGKNIRIVVMN 232
+ E + P Y+ + Q T L K G+Y + K + ++VM
Sbjct: 1879 MPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVME 1938
Query: 233 NLLPRSVKMHIKYDLKGSTYKRRA-SQKEREKPLPTFKDLDFLQDIPDG-LFLDADMYNA 290
NL KM +DLKGS R + +E D + L+ + D L++ +
Sbjct: 1939 NLF-YGRKMAQVFDLKGSLRNRNVKTDTGKESCDVVLLDENLLKMVRDNPLYIRSHSKAV 1997
Query: 291 LCKTLQRDCLVLQSFKIMDYSLLM 314
L ++ D L S I+DYSLL+
Sbjct: 1998 LRTSIHSDSHFLSSHLIIDYSLLV 2021
>gi|18105056 vacuolar protein sorting 33A [Homo sapiens]
Length = 596
Score = 33.9 bits (76), Expect = 0.40
Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 7/85 (8%)
Query: 342 PQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKK 401
P+ L E++ E RRG T D H+ +P R+ E+ L +G++ F+ +
Sbjct: 85 PRLELMDIIAENVLSEDRRGPTR--DFHILFVPRRSLLCEQRLKDLGVLG-----SFIHR 137
Query: 402 LEHSWKALVHDGDTVSVHRPGFYAE 426
E+S + DGD +S+ G + E
Sbjct: 138 EEYSLDLIPFDGDLLSMESEGAFKE 162
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 33.5 bits (75), Expect = 0.52
Identities = 27/112 (24%), Positives = 48/112 (42%), Gaps = 7/112 (6%)
Query: 437 FKKIPLKPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGR 496
F + + S S S+ SR + S ++ ++ S + A+ +T A L R
Sbjct: 392 FNTLDVGASGLNTSHSPSASSRSSHKSSHTAMSEPTSTPTKLMAEASTPA-------LPR 444
Query: 497 PDVLPQTPPLEEISEGSPIPDPSFSPLVGETLQMLTTSTTLEKLEVAESEFT 548
LPQ P+ +S+ + +P P SP + Q L T L+ ++F+
Sbjct: 445 SATLPQELPVPGLSQAATMPAPLPSPSSCDLTQQLLPQTVLQSTPAPMAQFS 496
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 32.7 bits (73), Expect = 0.88
Identities = 38/165 (23%), Positives = 62/165 (37%), Gaps = 27/165 (16%)
Query: 379 KGERLLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFK 438
+GE ++ + + +++ + +LEH W+ + V + + R +C +
Sbjct: 529 RGEHAMITARLEETIENLKH--ELEHRWRGGCEERKDVCISTDDDCPPKTFRNVCVQTDR 586
Query: 439 KIPLKP--SPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHK------------AQVTT 484
+ LKP S SK RS ++ S S Q S +HK A
Sbjct: 587 ETFLKPCESESKTTRSNQLVPKKLNISSLS----QLSPPNDHKDIHAALQPMEGMASNQQ 642
Query: 485 KAEVEPGVHLGRPDVLPQ-------TPPLEEISEGSPIPDPSFSP 522
KA P + P LP PP+ +S G P+P P P
Sbjct: 643 KALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPP 687
>gi|222537754 hypothetical protein LOC375337 [Homo sapiens]
Length = 1692
Score = 32.3 bits (72), Expect = 1.2
Identities = 11/46 (23%), Positives = 29/46 (63%)
Query: 271 LDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSI 316
+++ + P G++ D + N L +L + CL+ + F+I++ S+++ +
Sbjct: 1150 MEYYRKFPPGVYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKM 1195
>gi|33457336 chromosome 14 open reading frame 4 [Homo sapiens]
Length = 796
Score = 32.0 bits (71), Expect = 1.5
Identities = 26/83 (31%), Positives = 34/83 (40%), Gaps = 5/83 (6%)
Query: 443 KPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVHLGRPD---V 499
+ SP+ + S SRR G +T P+ G Q+T + P L P V
Sbjct: 213 RQSPNSSSAAASVASRRGTHGG--LVTGLPNPGGGGGPQLTVPPNLLPQTLLNGPASAAV 270
Query: 500 LPQTPPLEEISEGSPIPDPSFSP 522
LP PP S G P P P +P
Sbjct: 271 LPPPPPHALGSRGPPTPAPPGAP 293
>gi|221139926 NHS-like 1 [Homo sapiens]
Length = 1606
Score = 31.2 bits (69), Expect = 2.6
Identities = 27/100 (27%), Positives = 37/100 (37%), Gaps = 14/100 (14%)
Query: 443 KPSPSKKFRSGSSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPGVH--------- 493
KP P R S S + SS ++ ++ S G + A P
Sbjct: 880 KPKPKVPERKSSLISSVSISSSSTSLSSSTSTEGSGTMKKLDPAVGSPPAPPPPPVPSPP 939
Query: 494 ----LGRPDVLPQTPPLEEISEGSPIP-DPSFSPLVGETL 528
R LP PP+ + S+GSP+P P F P E L
Sbjct: 940 FPCPADRSPFLPPPPPVTDCSQGSPLPHSPVFPPPPPEAL 979
>gi|193083221 mast cell immunoreceptor signal transducer [Homo
sapiens]
Length = 428
Score = 30.4 bits (67), Expect = 4.4
Identities = 21/82 (25%), Positives = 36/82 (43%), Gaps = 2/82 (2%)
Query: 307 IMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRP--APQKALYSTAMESIQGEARRGGTM 364
+ D S ++ + H QR+P S+ + +T+ A + ++T+ S+Q RGG
Sbjct: 205 LRDLSEVLEAEKVPHNQRKPESTHLLENQNTQEIPLAISSSSFTTSNHSVQNRDHRGGMQ 264
Query: 365 ETDDHMGGIPARNSKGERLLLY 386
PA S E +L Y
Sbjct: 265 PCSPQRCQPPASCSPHENILPY 286
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 30.0 bits (66), Expect = 5.7
Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 6/83 (7%)
Query: 443 KPSPSKKFRSGSSFSRRAGSS-GNSCI----TYQPSVSGEHKAQV-TTKAEVEPGVHLGR 496
+P SK ++ +F R S C TY + S + ++ T E EPG HL
Sbjct: 1073 EPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDP 1132
Query: 497 PDVLPQTPPLEEISEGSPIPDPS 519
P + E + P DPS
Sbjct: 1133 PQFVENVTLPENVDFPDPYQDPS 1155
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 30.0 bits (66), Expect = 5.7
Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 6/83 (7%)
Query: 443 KPSPSKKFRSGSSFSRRAGSS-GNSCI----TYQPSVSGEHKAQV-TTKAEVEPGVHLGR 496
+P SK ++ +F R S C TY + S + ++ T E EPG HL
Sbjct: 1073 EPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDP 1132
Query: 497 PDVLPQTPPLEEISEGSPIPDPS 519
P + E + P DPS
Sbjct: 1133 PQFVENVTLPENVDFPDPYQDPS 1155
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 30.0 bits (66), Expect = 5.7
Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 6/83 (7%)
Query: 443 KPSPSKKFRSGSSFSRRAGSS-GNSCI----TYQPSVSGEHKAQV-TTKAEVEPGVHLGR 496
+P SK ++ +F R S C TY + S + ++ T E EPG HL
Sbjct: 1073 EPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDP 1132
Query: 497 PDVLPQTPPLEEISEGSPIPDPS 519
P + E + P DPS
Sbjct: 1133 PQFVENVTLPENVDFPDPYQDPS 1155
>gi|58530863 melanoma antigen family A, 10 [Homo sapiens]
Length = 369
Score = 29.6 bits (65), Expect = 7.5
Identities = 29/92 (31%), Positives = 40/92 (43%), Gaps = 6/92 (6%)
Query: 454 SSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPG-VHLGRPDVLPQTPPLEEISEG 512
SSF + SS +SC PS E A T + + P V+ PL++ EG
Sbjct: 50 SSFPSSSSSSSSSCYPLIPSTPEEVSADDETPNPPQSAQIACSSPSVVASL-PLDQSDEG 108
Query: 513 SPIPDPSFSPLVGETLQMLTTSTTLEKLEVAE 544
S SP TLQ+L S +L + E+ E
Sbjct: 109 SS-SQKEESP---STLQVLPDSESLPRSEIDE 136
>gi|10567820 melanoma antigen family A, 10 [Homo sapiens]
Length = 369
Score = 29.6 bits (65), Expect = 7.5
Identities = 29/92 (31%), Positives = 40/92 (43%), Gaps = 6/92 (6%)
Query: 454 SSFSRRAGSSGNSCITYQPSVSGEHKAQVTTKAEVEPG-VHLGRPDVLPQTPPLEEISEG 512
SSF + SS +SC PS E A T + + P V+ PL++ EG
Sbjct: 50 SSFPSSSSSSSSSCYPLIPSTPEEVSADDETPNPPQSAQIACSSPSVVASL-PLDQSDEG 108
Query: 513 SPIPDPSFSPLVGETLQMLTTSTTLEKLEVAE 544
S SP TLQ+L S +L + E+ E
Sbjct: 109 SS-SQKEESP---STLQVLPDSESLPRSEIDE 136
>gi|4504425 high-mobility group box 1 [Homo sapiens]
Length = 215
Score = 29.3 bits (64), Expect = 9.8
Identities = 24/88 (27%), Positives = 35/88 (39%), Gaps = 18/88 (20%)
Query: 398 FVKKLEHSWKALVHDGDTVSVHRPGFYAE-------RFQRFMCNTVFKKIPLKPSPSKKF 450
F KK WK T+S G + + R++R M IP K KKF
Sbjct: 41 FSKKCSERWK-------TMSAKEKGKFEDMAKADKARYEREMKTY----IPPKGETKKKF 89
Query: 451 RSGSSFSRRAGSSGNSCITYQPSVSGEH 478
+ ++ R + C Y+P + GEH
Sbjct: 90 KDPNAPKRPPSAFFLFCSEYRPKIKGEH 117
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 29.3 bits (64), Expect = 9.8
Identities = 17/53 (32%), Positives = 33/53 (62%), Gaps = 2/53 (3%)
Query: 246 DLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMY-NALCKTLQR 297
DL+ + + S+ E +P P K LD++QD G+F +A +Y +++ ++L+R
Sbjct: 284 DLENEPWYKFFSELEFGRPPPK-KPLDYVQDHSSGVFNEASLYQSSIDRSLER 335
>gi|14277690 hypothetical protein LOC9750 isoform 2 [Homo sapiens]
Length = 591
Score = 29.3 bits (64), Expect = 9.8
Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 248 KGSTYKRRASQKEREKP-LPTFKDLDFLQDIPDGLF 282
K + +RR S + P PTFKD F ++PD +F
Sbjct: 332 KAAALQRRMSMYSQGTPETPTFKDHSFFSNLPDDIF 367
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,049,064
Number of Sequences: 37866
Number of extensions: 1070442
Number of successful extensions: 3077
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 3026
Number of HSP's gapped (non-prelim): 40
length of query: 549
length of database: 18,247,518
effective HSP length: 107
effective length of query: 442
effective length of database: 14,195,856
effective search space: 6274568352
effective search space used: 6274568352
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.