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Search of human proteins with 4505695
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505695 3-phosphoinositide dependent protein kinase-1
isoform 1 [Homo sapiens]
(556 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform... 1137 0.0
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ... 740 0.0
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ... 710 0.0
gi|47680169 3-phosphoinositide dependent protein kinase-1 isofor... 663 0.0
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 216 4e-56
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 216 4e-56
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 216 4e-56
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 216 4e-56
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 214 2e-55
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 214 2e-55
gi|4826948 protein kinase, X-linked [Homo sapiens] 214 2e-55
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 211 1e-54
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 211 1e-54
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 207 2e-53
gi|4502023 AKT2 kinase [Homo sapiens] 202 9e-52
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 201 1e-51
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 201 1e-51
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 198 9e-51
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 196 4e-50
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 196 4e-50
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 196 5e-50
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 196 5e-50
gi|62241015 AKT1 kinase [Homo sapiens] 196 6e-50
gi|62241013 AKT1 kinase [Homo sapiens] 196 6e-50
gi|62241011 AKT1 kinase [Homo sapiens] 196 6e-50
gi|5453976 protein kinase C, theta [Homo sapiens] 194 2e-49
gi|4506067 protein kinase C, alpha [Homo sapiens] 192 9e-49
gi|28557781 protein kinase C, eta [Homo sapiens] 191 1e-48
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 191 1e-48
gi|4885563 protein kinase C, epsilon [Homo sapiens] 191 2e-48
>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
[Homo sapiens]
Length = 556
Score = 1137 bits (2941), Expect = 0.0
Identities = 556/556 (100%), Positives = 556/556 (100%)
Query: 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP 60
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
Sbjct: 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP 60
Query: 61 GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK 120
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK
Sbjct: 61 GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIK 120
Query: 121 ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET 180
ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET
Sbjct: 121 ENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDET 180
Query: 181 CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN 240
CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN
Sbjct: 181 CTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARAN 240
Query: 241 SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD 300
SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD
Sbjct: 241 SFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYD 300
Query: 301 FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA 360
FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
Sbjct: 301 FPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA 360
Query: 361 YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD 420
YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD
Sbjct: 361 YLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLD 420
Query: 421 SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE 480
SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE
Sbjct: 421 SNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTE 480
Query: 481 GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ 540
GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ
Sbjct: 481 GPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQ 540
Query: 541 EVWRQRYQSHPDAAVQ 556
EVWRQRYQSHPDAAVQ
Sbjct: 541 EVWRQRYQSHPDAAVQ 556
>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
protein kinase-1 [Homo sapiens]
Length = 471
Score = 740 bits (1911), Expect = 0.0
Identities = 363/367 (98%), Positives = 364/367 (99%)
Query: 9 YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA 68
YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA
Sbjct: 28 YDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHA 87
Query: 69 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT 128
QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT
Sbjct: 88 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT 147
Query: 129 RERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 188
RERDVMSRLDHPFFVKLYFTFQ +LYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE
Sbjct: 148 RERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 207
Query: 189 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 248
IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY
Sbjct: 208 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 267
Query: 249 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 308
VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK
Sbjct: 268 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 327
Query: 309 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSED 368
ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSED
Sbjct: 328 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSED 387
Query: 369 DEDCYGN 375
DEDCYGN
Sbjct: 388 DEDCYGN 394
>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
sapiens]
Length = 396
Score = 710 bits (1832), Expect = 0.0
Identities = 348/348 (100%), Positives = 348/348 (100%)
Query: 28 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 87
MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI
Sbjct: 1 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 60
Query: 88 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 147
LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF
Sbjct: 61 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 120
Query: 148 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 207
TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK
Sbjct: 121 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 180
Query: 208 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 267
PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA
Sbjct: 181 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 240
Query: 268 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 327
LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC
Sbjct: 241 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 300
Query: 328 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN 375
EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN
Sbjct: 301 EEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGN 348
>gi|47680169 3-phosphoinositide dependent protein kinase-1 isoform 2
[Homo sapiens]
Length = 429
Score = 663 bits (1710), Expect = 0.0
Identities = 319/319 (100%), Positives = 319/319 (100%)
Query: 238 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 297
RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL
Sbjct: 111 RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKL 170
Query: 298 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 357
EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK
Sbjct: 171 EYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPK 230
Query: 358 LTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIH 417
LTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIH
Sbjct: 231 LTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIH 290
Query: 418 DLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLL 477
DLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLL
Sbjct: 291 DLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLL 350
Query: 478 LTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCR 537
LTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCR
Sbjct: 351 LTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCR 410
Query: 538 KIQEVWRQRYQSHPDAAVQ 556
KIQEVWRQRYQSHPDAAVQ
Sbjct: 411 KIQEVWRQRYQSHPDAAVQ 429
Score = 223 bits (567), Expect = 5e-58
Identities = 109/111 (98%), Positives = 110/111 (99%)
Query: 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP 60
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP
Sbjct: 1 MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRP 60
Query: 61 GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIK 111
GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYA +
Sbjct: 61 GAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYATR 111
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 216 bits (550), Expect = 4e-56
Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)
Query: 47 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 106
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 64 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 122
Query: 107 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 165
YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQ +KLYF L Y G
Sbjct: 123 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 182
Query: 166 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 225
EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG
Sbjct: 183 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 242
Query: 226 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 285
K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF +
Sbjct: 243 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 300
Query: 286 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 345
N ++ I+ AR L+E LL D TKRLG + + + +K+H FF +
Sbjct: 301 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 358
Query: 346 TWENLHQQ--TPP 356
W++L + TPP
Sbjct: 359 NWDDLINKKITPP 371
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 216 bits (550), Expect = 4e-56
Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)
Query: 47 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 106
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 78 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 136
Query: 107 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 165
YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQ +KLYF L Y G
Sbjct: 137 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 196
Query: 166 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 225
EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG
Sbjct: 197 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 256
Query: 226 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 285
K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF +
Sbjct: 257 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 314
Query: 286 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 345
N ++ I+ AR L+E LL D TKRLG + + + +K+H FF +
Sbjct: 315 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 372
Query: 346 TWENLHQQ--TPP 356
W++L + TPP
Sbjct: 373 NWDDLINKKITPP 385
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 216 bits (550), Expect = 4e-56
Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)
Query: 47 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 106
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 92 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 150
Query: 107 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 165
YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQ +KLYF L Y G
Sbjct: 151 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 210
Query: 166 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 225
EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG
Sbjct: 211 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 270
Query: 226 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 285
K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF +
Sbjct: 271 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 328
Query: 286 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 345
N ++ I+ AR L+E LL D TKRLG + + + +K+H FF +
Sbjct: 329 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 386
Query: 346 TWENLHQQ--TPP 356
W++L + TPP
Sbjct: 387 NWDDLINKKITPP 399
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 216 bits (550), Expect = 4e-56
Identities = 120/313 (38%), Positives = 180/313 (57%), Gaps = 8/313 (2%)
Query: 47 QGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSR 106
Q P + P P + P P K P DF F K++G+GSF V+LAR A
Sbjct: 159 QEPELMNANPSPPPSPSQQINLGPSSNPHAK-PSDFHFLKVIGKGSFGKVLLARHKAEEV 217
Query: 107 EYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNG 165
YA+K+L+K+ I+K+ + ++ ER+V+ + + HPF V L+F+FQ +KLYF L Y G
Sbjct: 218 FYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGG 277
Query: 166 ELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFG 225
EL ++++ F E RFY AEI SAL YLH I++RDLKPENILL+ HI +TDFG
Sbjct: 278 ELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFG 337
Query: 226 TAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAG 285
K + ++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF +
Sbjct: 338 LCK--ENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSR 395
Query: 286 NEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 345
N ++ I+ AR L+E LL D TKRLG + + + +K+H FF +
Sbjct: 396 NTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHVFFSLI 453
Query: 346 TWENLHQQ--TPP 356
W++L + TPP
Sbjct: 454 NWDDLINKKITPP 466
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 214 bits (545), Expect = 2e-55
Identities = 106/274 (38%), Positives = 165/274 (60%), Gaps = 6/274 (2%)
Query: 80 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 139
EDF+ K LG GSF V+L + AT + YA+KIL+K+ ++K ++ + E+ ++ ++
Sbjct: 42 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101
Query: 140 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 199
PF V+L + F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH
Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
Query: 200 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 259
+I+RDLKPEN+L++ +IQ+TDFG AK + + R + GT +Y++PE++ K
Sbjct: 162 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216
Query: 260 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 319
K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL +
Sbjct: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276
Query: 320 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 353
D TKR G G +K H +F + W ++Q+
Sbjct: 277 DLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 309
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 214 bits (545), Expect = 2e-55
Identities = 106/274 (38%), Positives = 165/274 (60%), Gaps = 6/274 (2%)
Query: 80 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 139
EDF+ K LG GSF V+L + AT + YA+KIL+K+ ++K ++ + E+ ++ ++
Sbjct: 89 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 148
Query: 140 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 199
PF V+L + F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH
Sbjct: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 208
Query: 200 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 259
+I+RDLKPEN+L++ +IQ+TDFG AK + + R + GT +Y++PE++ K
Sbjct: 209 DLIYRDLKPENLLIDHQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 263
Query: 260 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 319
K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL +
Sbjct: 264 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 323
Query: 320 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 353
D TKR G G +K H +F + W ++Q+
Sbjct: 324 DLTKRFG-NLKNGVSDIKTHKWFATTDWIAIYQR 356
>gi|4826948 protein kinase, X-linked [Homo sapiens]
Length = 358
Score = 214 bits (545), Expect = 2e-55
Identities = 110/282 (39%), Positives = 169/282 (59%), Gaps = 6/282 (2%)
Query: 72 PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRER 131
P+P +DF +G G+F V L +E +A+K++ +I+ + +V E+
Sbjct: 39 PEPPVYSLQDFDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEK 98
Query: 132 DVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 191
V+ + HPF ++L++T+ D+ LY + Y GEL Y+R G F T FY+AEI+
Sbjct: 99 SVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIIC 158
Query: 192 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 251
A+EYLH K I++RDLKPENILL+ D HI++TDFG AK L R + GT +Y++P
Sbjct: 159 AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD-----RTWTLCGTPEYLAP 213
Query: 252 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 311
E++ K ++ D WALG +I+++++G PPF N + I+QKI+ + DFP +D
Sbjct: 214 EVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKD 273
Query: 312 LVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 353
L++KLLV+D T+RLG G +K H +F SV WE + Q+
Sbjct: 274 LIKKLLVVDRTRRLG-NMKNGANDVKHHRWFRSVDWEAVPQR 314
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 211 bits (537), Expect = 1e-54
Identities = 105/274 (38%), Positives = 164/274 (59%), Gaps = 6/274 (2%)
Query: 80 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 139
+ F+ K LG GSF V+L + T YA+KIL+K+ ++K ++ + E+ ++ ++
Sbjct: 34 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 93
Query: 140 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 199
PF VKL F+F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH
Sbjct: 94 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 153
Query: 200 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 259
+I+RDLKPEN+L+++ +IQ+TDFG AK + + R + GT +Y++PE++ K
Sbjct: 154 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 208
Query: 260 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 319
K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL +
Sbjct: 209 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 268
Query: 320 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 353
D TKR G G +K H +F + W ++Q+
Sbjct: 269 DLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 301
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 211 bits (537), Expect = 1e-54
Identities = 105/274 (38%), Positives = 164/274 (59%), Gaps = 6/274 (2%)
Query: 80 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 139
+ F+ K LG GSF V+L + T YA+KIL+K+ ++K ++ + E+ ++ ++
Sbjct: 42 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101
Query: 140 PFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGK 199
PF VKL F+F+D+ LY + Y GE+ ++R+IG F E RFY A+IV EYLH
Sbjct: 102 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSL 161
Query: 200 GIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSA 259
+I+RDLKPEN+L+++ +IQ+TDFG AK + + R + GT +Y++PE++ K
Sbjct: 162 DLIYRDLKPENLLIDQQGYIQVTDFGFAKRV-----KGRTWTLCGTPEYLAPEIILSKGY 216
Query: 260 CKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVL 319
K+ D WALG +IY++ AG PPF A I++KI+ + FP F +DL+ LL +
Sbjct: 217 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQV 276
Query: 320 DATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 353
D TKR G G +K H +F + W ++Q+
Sbjct: 277 DLTKRFG-NLKNGVNDIKNHKWFATTDWIAIYQR 309
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 207 bits (528), Expect = 2e-53
Identities = 108/303 (35%), Positives = 171/303 (56%), Gaps = 11/303 (3%)
Query: 72 PQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRER 131
P + F+ + LG GSF V+L R T YA+KIL K+ ++K +V ++ E+
Sbjct: 34 PAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEK 93
Query: 132 DVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 191
++ +D PF VKL F+F+D+ LY + Y GE+ ++++G F E FY A++V
Sbjct: 94 RILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVL 153
Query: 192 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 251
A++YLH +IHRDLKPEN+L+++ ++Q+TDFG AK + + R + GT +Y++P
Sbjct: 154 AVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRV-----KGRTWTLCGTPEYLAP 208
Query: 252 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 311
E++ K K+ D WALG +IY++ G PPF A I++KI+ FP K +
Sbjct: 209 EIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKH 268
Query: 312 LVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTP-----PKLTAYLPAMS 366
L+ LL +D TKR G G G +K H +F + +W ++++ PK T A +
Sbjct: 269 LLRSLLQVDLTKRFG-NLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASN 327
Query: 367 EDD 369
DD
Sbjct: 328 FDD 330
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 202 bits (513), Expect = 9e-52
Identities = 122/348 (35%), Positives = 186/348 (53%), Gaps = 15/348 (4%)
Query: 28 MVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKI 87
MV + P P + G D + E A S A K DF + K+
Sbjct: 105 MVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARA-------KVTMNDFDYLKL 157
Query: 88 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYF 147
LG+G+F V+L RE AT R YA+KIL K II +++V + E V+ HPF L +
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
Query: 148 TFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLK 207
FQ ++L F + YA GEL ++ + F E RFY AEIVSALEYLH + +++RD+K
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
Query: 208 PENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWA 267
EN++L++D HI+ITDFG K S A +F GT +Y++PE+L + ++ D W
Sbjct: 278 LENLMLDKDGHIKITDFGLCK--EGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 335
Query: 268 LGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGC 327
LG ++Y+++ G PF + +F+ I+ E FP P+A+ L+ LL D +RLG
Sbjct: 336 LGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGG 395
Query: 328 EEMEGYGPLKAHPFFESVTWENLHQQT-----PPKLTAYLPAMSEDDE 370
+ ++ H FF S+ W+++ Q+ P++T+ + DDE
Sbjct: 396 GPSDAKEVME-HRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDE 442
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 201 bits (512), Expect = 1e-51
Identities = 108/281 (38%), Positives = 161/281 (57%), Gaps = 7/281 (2%)
Query: 74 PRKKRPEDFKFGKILGEGSFSTVVLARELA---TSREYAIKILEKRHIIKENK-VPYVTR 129
P K RPE F+ ++LG+G + V R++ T + +A+K+L+K I++ K +
Sbjct: 83 PEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA 142
Query: 130 ERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEI 189
ER+++ + HPF V L + FQ KLY L Y GEL + + G F E FY AEI
Sbjct: 143 ERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEI 202
Query: 190 VSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYV 249
AL +LH KGII+RDLKPENI+LN H+++TDFG K + ++F GT +Y+
Sbjct: 203 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDG--TVTHTFCGTIEYM 260
Query: 250 SPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKA 309
+PE+L ++ D W+LG ++Y ++ G PPF N KI+K + + P +A
Sbjct: 261 APEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEA 320
Query: 310 RDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL 350
RDL++KLL +A RLG + G ++AHPFF + WE L
Sbjct: 321 RDLLKKLLKRNAASRLGAGPGDA-GEVQAHPFFRHINWEEL 360
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 201 bits (511), Expect = 1e-51
Identities = 112/323 (34%), Positives = 183/323 (56%), Gaps = 9/323 (2%)
Query: 38 PPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVV 97
PP +P + + P+P + P +P DF F K++G+G++ V+
Sbjct: 51 PPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVL 110
Query: 98 LARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLY 156
LA+ + YA+K+L+K+ I+K+ + ++ ER V+ + + HPF V L ++FQ EKLY
Sbjct: 111 LAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLY 170
Query: 157 FGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNED 216
F L Y GEL ++++ F E RFY AE+ SA+ YLH II+RDLKPENILL+
Sbjct: 171 FVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQ 230
Query: 217 MHIQITDFGTAKV-LSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQL 275
H+ +TDFG K + PE ++F GT +Y++PE+L ++ ++ D W LG ++Y++
Sbjct: 231 GHVVLTDFGLCKEGVEPED---TTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEM 287
Query: 276 VAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGP 335
+ GLPPF + + +++ I+ P A DL++ LL D +RLG + +
Sbjct: 288 LHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK--ADFLE 345
Query: 336 LKAHPFFESVTWENLHQQ--TPP 356
+K H FF + W++L+ + TPP
Sbjct: 346 IKNHVFFSPINWDDLYHKRLTPP 368
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 198 bits (504), Expect = 9e-51
Identities = 109/303 (35%), Positives = 177/303 (58%), Gaps = 9/303 (2%)
Query: 58 PRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRH 117
P+P + P +P DF F K++G+G++ V+LA+ + YA+K+L+K+
Sbjct: 11 PQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKS 70
Query: 118 IIKENKVPYVTRERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGS 176
I+K+ + ++ ER V+ + + HPF V L ++FQ EKLYF L Y GEL ++++
Sbjct: 71 ILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERR 130
Query: 177 FDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKV-LSPESK 235
F E RFY AE+ SA+ YLH II+RDLKPENILL+ H+ +TDFG K + PE
Sbjct: 131 FLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPED- 189
Query: 236 QARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKII 295
++F GT +Y++PE+L ++ ++ D W LG ++Y+++ GLPPF + + +++ I+
Sbjct: 190 --TTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENIL 247
Query: 296 KLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ-- 353
P A DL++ LL D +RLG + + +K H FF + W++L+ +
Sbjct: 248 HQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSK--ADFLEIKNHVFFSPINWDDLYHKRL 305
Query: 354 TPP 356
TPP
Sbjct: 306 TPP 308
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 196 bits (499), Expect = 4e-50
Identities = 107/288 (37%), Positives = 169/288 (58%), Gaps = 6/288 (2%)
Query: 70 PPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR 129
P P K P DF F K++G+GSF V+LA+ + YA+K+L+K+ ++ + ++
Sbjct: 151 PSGNPHAK-PTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMA 209
Query: 130 ERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 188
ER+V+ + + HPF V L+++FQ EKLYF L + GEL ++++ SF E RFY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269
Query: 189 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 248
I SAL YLH I++RDLKPENILL+ H+ +TDFG K + +F GT +Y
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCK--EGIAISDTTTTFCGTPEY 327
Query: 249 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 308
++PE++ ++ + D W LG ++Y+++ GLPPF + ++ I+
Sbjct: 328 LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLT 387
Query: 309 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 356
A ++E+LL D RLG + E + ++ HPFFES++W +L Q+ P
Sbjct: 388 AWSILEELLEKDRQNRLGAK--EDFLEIQNHPFFESLSWADLVQKKIP 433
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 196 bits (499), Expect = 4e-50
Identities = 107/288 (37%), Positives = 169/288 (58%), Gaps = 6/288 (2%)
Query: 70 PPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR 129
P P K P DF F K++G+GSF V+LA+ + YA+K+L+K+ ++ + ++
Sbjct: 151 PSGNPHAK-PTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMA 209
Query: 130 ERDVMSR-LDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 188
ER+V+ + + HPF V L+++FQ EKLYF L + GEL ++++ SF E RFY AE
Sbjct: 210 ERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAE 269
Query: 189 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQY 248
I SAL YLH I++RDLKPENILL+ H+ +TDFG K + +F GT +Y
Sbjct: 270 IASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCK--EGIAISDTTTTFCGTPEY 327
Query: 249 VSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 308
++PE++ ++ + D W LG ++Y+++ GLPPF + ++ I+
Sbjct: 328 LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLT 387
Query: 309 ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPP 356
A ++E+LL D RLG + E + ++ HPFFES++W +L Q+ P
Sbjct: 388 AWSILEELLEKDRQNRLGAK--EDFLEIQNHPFFESLSWADLVQKKIP 433
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 196 bits (498), Expect = 5e-50
Identities = 105/284 (36%), Positives = 166/284 (58%), Gaps = 5/284 (1%)
Query: 75 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 134
++K DF + K+LG+G+F V+L RE A+ + YA+KIL+K II +++V + E V+
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200
Query: 135 SRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 194
HPF L ++FQ ++L F + Y GEL ++ + F E TRFY AEIVSAL+
Sbjct: 201 KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 195 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 254
YLH I++RDLK EN++L++D HI+ITDFG K + A +F GT +Y++PE+L
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK--EGITDAATMKTFCGTPEYLAPEVL 318
Query: 255 TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVE 314
+ ++ D W LG ++Y+++ G PF + +F+ I+ + FP A+ L+
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLS 378
Query: 315 KLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 356
LL+ D KRLG + + H FF V W++++ + PP
Sbjct: 379 GLLIKDPNKRLG-GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 196 bits (498), Expect = 5e-50
Identities = 105/284 (36%), Positives = 166/284 (58%), Gaps = 5/284 (1%)
Query: 75 RKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVM 134
++K DF + K+LG+G+F V+L RE A+ + YA+KIL+K II +++V + E V+
Sbjct: 141 KRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVL 200
Query: 135 SRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALE 194
HPF L ++FQ ++L F + Y GEL ++ + F E TRFY AEIVSAL+
Sbjct: 201 KNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALD 260
Query: 195 YLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 254
YLH I++RDLK EN++L++D HI+ITDFG K + A +F GT +Y++PE+L
Sbjct: 261 YLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCK--EGITDAATMKTFCGTPEYLAPEVL 318
Query: 255 TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVE 314
+ ++ D W LG ++Y+++ G PF + +F+ I+ + FP A+ L+
Sbjct: 319 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLS 378
Query: 315 KLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ--TPP 356
LL+ D KRLG + + H FF V W++++ + PP
Sbjct: 379 GLLIKDPNKRLG-GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP 421
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 196 bits (497), Expect = 6e-50
Identities = 109/310 (35%), Positives = 180/310 (58%), Gaps = 7/310 (2%)
Query: 51 MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 109
MD + P +G+ + +P+ + +F++ K+LG+G+F V+L +E AT R YA
Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177
Query: 110 IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK 169
+KIL+K I+ +++V + E V+ HPF L ++FQ ++L F + YA GEL
Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 170 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 228
++ + F E RFY AEIVSAL+YLH K +++RDLK EN++L++D HI+ITDFG K
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 229 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 288
+ A +F GT +Y++PE+L + ++ D W LG ++Y+++ G PF +
Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355
Query: 289 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 348
+F+ I+ E FP P+A+ L+ LL D +RLG E + H FF + W+
Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414
Query: 349 NLHQQ--TPP 356
+++++ +PP
Sbjct: 415 HVYEKKLSPP 424
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 196 bits (497), Expect = 6e-50
Identities = 109/310 (35%), Positives = 180/310 (58%), Gaps = 7/310 (2%)
Query: 51 MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 109
MD + P +G+ + +P+ + +F++ K+LG+G+F V+L +E AT R YA
Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177
Query: 110 IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK 169
+KIL+K I+ +++V + E V+ HPF L ++FQ ++L F + YA GEL
Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 170 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 228
++ + F E RFY AEIVSAL+YLH K +++RDLK EN++L++D HI+ITDFG K
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 229 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 288
+ A +F GT +Y++PE+L + ++ D W LG ++Y+++ G PF +
Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355
Query: 289 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 348
+F+ I+ E FP P+A+ L+ LL D +RLG E + H FF + W+
Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414
Query: 349 NLHQQ--TPP 356
+++++ +PP
Sbjct: 415 HVYEKKLSPP 424
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 196 bits (497), Expect = 6e-50
Identities = 109/310 (35%), Positives = 180/310 (58%), Gaps = 7/310 (2%)
Query: 51 MDGTAAEPRPGAGSLQHAQPPPQPRKK-RPEDFKFGKILGEGSFSTVVLARELATSREYA 109
MD + P +G+ + +P+ + +F++ K+LG+G+F V+L +E AT R YA
Sbjct: 118 MDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYA 177
Query: 110 IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK 169
+KIL+K I+ +++V + E V+ HPF L ++FQ ++L F + YA GEL
Sbjct: 178 MKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFF 237
Query: 170 YIRKIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHIQITDFGTAK 228
++ + F E RFY AEIVSAL+YLH K +++RDLK EN++L++D HI+ITDFG K
Sbjct: 238 HLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCK 297
Query: 229 VLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEY 288
+ A +F GT +Y++PE+L + ++ D W LG ++Y+++ G PF +
Sbjct: 298 EGIKDG--ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 355
Query: 289 LIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 348
+F+ I+ E FP P+A+ L+ LL D +RLG E + H FF + W+
Sbjct: 356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG-GGSEDAKEIMQHRFFAGIVWQ 414
Query: 349 NLHQQ--TPP 356
+++++ +PP
Sbjct: 415 HVYEKKLSPP 424
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 194 bits (492), Expect = 2e-49
Identities = 120/361 (33%), Positives = 190/361 (52%), Gaps = 30/361 (8%)
Query: 3 RTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAE-PRPG 61
R T Q++ P++ + P ++ + PP +P ++ P G + E P
Sbjct: 305 RDTEQIFREGPVEIGL-------PCSIKNEAR---PPCLPTPGKREP--QGISWESPLDE 352
Query: 62 AGSLQHAQPPPQPRKKRP--------EDFKFGKILGEGSFSTVVLARELATSREYAIKIL 113
+ H P P+ K+RP EDF K+LG+GSF V LA T++ +AIK L
Sbjct: 353 VDKMCHL-PEPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKAL 411
Query: 114 EKRHIIKENKVPYVTRERDVMSRL-DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIR 172
+K ++ ++ V E+ V+S +HPF ++ TFQ E L+F + Y G+L+ +I+
Sbjct: 412 KKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQ 471
Query: 173 KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSP 232
FD + FY AEI+ L++LH KGI++RDLK +NILL++D HI+I DFG K
Sbjct: 472 SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCK--EN 529
Query: 233 ESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQ 292
A+ N+F GT Y++PE+L + S D W+ G ++Y+++ G PF +E +F
Sbjct: 530 MLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFH 589
Query: 293 KIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQ 352
I +P +A+DL+ KL V + KRLG G ++ HP F + WE L +
Sbjct: 590 SIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLGVR-----GDIRQHPLFREINWEELER 644
Query: 353 Q 353
+
Sbjct: 645 K 645
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 192 bits (487), Expect = 9e-49
Identities = 105/286 (36%), Positives = 164/286 (57%), Gaps = 4/286 (1%)
Query: 69 QPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT 128
QP + + DF F +LG+GSF V+LA T YAIKIL+K +I+++ V
Sbjct: 326 QPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTM 385
Query: 129 RERDVMSRLDHP-FFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTA 187
E+ V++ LD P F +L+ FQ ++LYF + Y G+L+ +I+++G F E FY A
Sbjct: 386 VEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAA 445
Query: 188 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 247
EI L +LH +GII+RDLK +N++L+ + HI+I DFG K + R +F GT
Sbjct: 446 EISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTR--TFCGTPD 503
Query: 248 YVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP 307
Y++PE++ + KS D WA G ++Y+++AG PPF +E +FQ I++ +P+
Sbjct: 504 YIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSK 563
Query: 308 KARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQ 353
+A + + L+ KRLGC EG ++ H FF + WE L +
Sbjct: 564 EAVSICKGLMTKHPAKRLGCGP-EGERDVREHAFFRRIDWEKLENR 608
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 191 bits (486), Expect = 1e-48
Identities = 101/279 (36%), Positives = 163/279 (58%), Gaps = 4/279 (1%)
Query: 80 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-D 138
++F+F ++LG+GSF V+LAR T YA+K+L+K I++++ V E+ ++S +
Sbjct: 353 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 412
Query: 139 HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHG 198
HPF +L+ FQ ++L+F + + G+L+ +I+K FDE RFY AEI+SAL +LH
Sbjct: 413 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHD 472
Query: 199 KGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKS 258
KGII+RDLK +N+LL+ + H ++ DFG K +F GT Y++PE+L E
Sbjct: 473 KGIIYRDLKLDNVLLDHEGHCKLADFGMCK--EGICNGVTTATFCGTPDYIAPEILQEML 530
Query: 259 ACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLV 318
+ D WA+G ++Y+++ G PF A NE +F+ I+ E +P A +++ +
Sbjct: 531 YGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT 590
Query: 319 LDATKRLGCEEMEGYGPLKAHPFFESVTWENL-HQQTPP 356
+ T RLG G + HPFF+ + W L H+Q P
Sbjct: 591 KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEP 629
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 191 bits (486), Expect = 1e-48
Identities = 105/303 (34%), Positives = 175/303 (57%), Gaps = 13/303 (4%)
Query: 76 KKRPEDFKFGKILGEGSFSTVVLARELATS---REYAIKILEKRHIIKENKVPYVTRERD 132
K P F+ K+LG+GSF V L ++++ S + YA+K+L+K + ++V ERD
Sbjct: 62 KADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVR-TKMERD 120
Query: 133 VMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSA 192
++ ++HPF VKL++ FQ + KLY L + + G+L + K F E +FY AE+ A
Sbjct: 121 ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA 180
Query: 193 LEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE 252
L++LH GII+RDLKPENILL+E+ HI++TDFG +K K +A SF GT +Y++PE
Sbjct: 181 LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEK--KAYSFCGTVEYMAPE 238
Query: 253 LLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDL 312
++ + +S+D W+ G ++++++ G PF+ + I+K + P+ P+A+ L
Sbjct: 239 VVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSL 298
Query: 313 VEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQT--PPKLTAYLPAMSEDDE 370
+ L + RLG +G +K H FF ++ W L+++ PP + PA ++
Sbjct: 299 LRMLFKRNPANRLGAGP-DGVEEIKRHSFFSTIDWNKLYRREIHPP----FKPATGRPED 353
Query: 371 DCY 373
Y
Sbjct: 354 TFY 356
Score = 108 bits (270), Expect = 1e-23
Identities = 85/277 (30%), Positives = 131/277 (47%), Gaps = 29/277 (10%)
Query: 88 LGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRL-DHPFFVKLY 146
+G GS+S AT+ E+A+KI++K + P T E +++ R HP + L
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDK-----SKRDP--TEEIEILLRYGQHPNIITLK 480
Query: 147 FTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDL 206
+ D + +Y K GELL I + F E I +EYLH +G++HRDL
Sbjct: 481 DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL 540
Query: 207 KPENILLNEDM----HIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKS 262
KP NIL ++ I+I DFG AK L E+ + TA +V+PE+L + +
Sbjct: 541 KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY--TANFVAPEVLKRQGYDAA 598
Query: 263 SDLWALGCIIYQLVAGLPPFRAGNEYL---IFQKI----IKLEYDFPEKFFPKARDLVEK 315
D+W+LG ++Y ++ G PF G + I +I L + A+DLV K
Sbjct: 599 CDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSK 658
Query: 316 LLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQ 352
+L +D +RL + HP+ V W+ L Q
Sbjct: 659 MLHVDPHQRLTA------ALVLRHPWI--VHWDQLPQ 687
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 191 bits (484), Expect = 2e-48
Identities = 101/283 (35%), Positives = 163/283 (57%), Gaps = 4/283 (1%)
Query: 73 QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERD 132
Q ++ ++F F K+LG+GSF V+LA YA+K+L+K I++++ V E+
Sbjct: 399 QAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKR 458
Query: 133 VMSRL-DHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVS 191
+++ HP+ +LY FQ ++L+F + Y G+L+ I++ FDE +RFY AE+ S
Sbjct: 459 ILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTS 518
Query: 192 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 251
AL +LH G+I+RDLK +NILL+ + H ++ DFG K +F GT Y++P
Sbjct: 519 ALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCK--EGILNGVTTTTFCGTPDYIAP 576
Query: 252 ELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 311
E+L E S D WALG ++Y+++AG PPF A NE +F+ I+ + +P +A
Sbjct: 577 EILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVS 636
Query: 312 LVEKLLVLDATKRLGC-EEMEGYGPLKAHPFFESVTWENLHQQ 353
+++ + + KRLGC G +K HPFF+ + W L Q+
Sbjct: 637 ILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQK 679
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,698,285
Number of Sequences: 37866
Number of extensions: 1219895
Number of successful extensions: 8034
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 759
Number of HSP's successfully gapped in prelim test: 139
Number of HSP's that attempted gapping in prelim test: 5393
Number of HSP's gapped (non-prelim): 1312
length of query: 556
length of database: 18,247,518
effective HSP length: 107
effective length of query: 449
effective length of database: 14,195,856
effective search space: 6373939344
effective search space used: 6373939344
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.