Search of human proteins with 4505531

Search of human proteins with 4505531

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505531 oxysterol binding protein [Homo sapiens]
         (807 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505531 oxysterol binding protein [Homo sapiens]                  1653   0.0  
gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens]      949   0.0  
gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo sa...   331   2e-90
gi|21735584 oxysterol-binding protein-like protein 3 isoform d [...   310   3e-84
gi|21735582 oxysterol-binding protein-like protein 3 isoform c [...   293   4e-79
gi|21735580 oxysterol-binding protein-like protein 3 isoform b [...   293   4e-79
gi|14149704 oxysterol-binding protein-like protein 3 isoform a [...   293   4e-79
gi|19718746 oxysterol-binding protein-like 1A isoform A [Homo sa...   290   4e-78
gi|21450853 oxysterol-binding protein-like protein 2 isoform 2 [...   282   8e-76
gi|7662298 oxysterol-binding protein-like protein 2 isoform 1 [H...   282   8e-76
gi|14210532 oxysterol-binding protein-like protein 6 isoform a [...   270   4e-72
gi|22035612 oxysterol-binding protein-like protein 6 isoform b [...   268   1e-71
gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens]   257   3e-68
gi|20070331 oxysterol binding protein-like 9 isoform e [Homo sap...   115   2e-25
gi|22547173 oxysterol binding protein-like 9 isoform d [Homo sap...   115   2e-25
gi|19923592 oxysterol binding protein-like 11 [Homo sapiens]          114   4e-25
gi|22547176 oxysterol binding protein-like 9 isoform f [Homo sap...   114   4e-25
gi|19923812 oxysterol-binding protein-like protein 10 [Homo sapi...   110   4e-24
gi|14149740 oxysterol-binding protein-like protein 5 isoform a [...   102   1e-21
gi|221136766 oxysterol-binding protein-like protein 5 isoform b ...   102   1e-21
gi|22035609 oxysterol-binding protein-like protein 5 isoform b [...   102   1e-21
gi|51243032 oxysterol-binding protein-like protein 8 isoform b [...   100   7e-21
gi|18079218 oxysterol-binding protein-like protein 8 isoform a [...   100   7e-21
gi|54792084 pleckstrin homology domain containing, family A (pho...    96   1e-19
gi|14249174 pleckstrin homology domain containing, family A (pho...    88   3e-17
gi|194294543 alpha 3 type IV collagen binding protein isoform 3 ...    87   5e-17
gi|14165452 alpha 3 type IV collagen binding protein isoform 2 [...    83   1e-15
gi|5031717 alpha 3 type IV collagen binding protein isoform 1 [H...    83   1e-15
gi|22547171 oxysterol binding protein-like 9 isoform c [Homo sap...    64   4e-10
gi|22547169 oxysterol binding protein-like 9 isoform b [Homo sap...    64   4e-10

>gi|4505531 oxysterol binding protein [Homo sapiens]
          Length = 807

 Score = 1653 bits (4280), Expect = 0.0
 Identities = 807/807 (100%), Positives = 807/807 (100%)

Query: 1   MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGP 60
           MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGP
Sbjct: 1   MAATELRGVVGPGPAAIAALGGGGAGPPVVGGGGGRGDAGPGSGAASGTVVAAAAGGPGP 60

Query: 61  GAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYY 120
           GAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYY
Sbjct: 61  GAGGVAAAGPAPAPPTGGSGGSGAGGSGSAREGWLFKWTNYIKGYQRRWFVLSNGLLSYY 120

Query: 121 RSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAK 180
           RSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAK
Sbjct: 121 RSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAK 180

Query: 181 AKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLS 240
           AKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLS
Sbjct: 181 AKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLS 240

Query: 241 ELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQ 300
           ELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQ
Sbjct: 241 ELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQ 300

Query: 301 RIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFF 360
           RIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFF
Sbjct: 301 RIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFF 360

Query: 361 DAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLW 420
           DAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLW
Sbjct: 361 DAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLW 420

Query: 421 SIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFT 480
           SIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFT
Sbjct: 421 SIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFT 480

Query: 481 VSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLR 540
           VSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLR
Sbjct: 481 VSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLR 540

Query: 541 QEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDI 600
           QEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDI
Sbjct: 541 QEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDI 600

Query: 601 VNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIG 660
           VNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIG
Sbjct: 601 VNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIG 660

Query: 661 ENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPD 720
           ENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPD
Sbjct: 661 ENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPD 720

Query: 721 QRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVT 780
           QRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVT
Sbjct: 721 QRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVT 780

Query: 781 KELTHIYRGEYWECKEKQDWSSCPDIF 807
           KELTHIYRGEYWECKEKQDWSSCPDIF
Sbjct: 781 KELTHIYRGEYWECKEKQDWSSCPDIF 807


>gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens]
          Length = 916

 Score =  949 bits (2453), Expect = 0.0
 Identities = 496/827 (59%), Positives = 606/827 (73%), Gaps = 46/827 (5%)

Query: 24  GAGPPVVGGGGGRGDAGPGSGAASGTVVAAA------AGGPG----PGAGGVAAAGPAPA 73
           GAG P     G R  +   SG  +G    AA      A G      P +G + A  P P 
Sbjct: 93  GAGQPSELLQGSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPL 152

Query: 74  PPTG------GSGGSGAGGSGSAR---------EGWLFKWTNYIKGYQRRWFVLSNGLLS 118
              G      G   SG G + SA          EGWL KWTNY+KGYQRRWFVL NGLLS
Sbjct: 153 LRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLS 212

Query: 119 YYRSKAEMRHTCRGTINLATANITVEDSCNFIISNGGAQTYHLKASSEVERQRWVTALEL 178
           YYR++ EM HTCRGTINL+TA+I  EDSC  ++++G A++YHLKASSEV+RQ+W+TALEL
Sbjct: 213 YYRNQGEMAHTCRGTINLSTAHIDTEDSCGILLTSG-ARSYHLKASSEVDRQQWITALEL 271

Query: 179 AKAKAVKML-AESDESGDE-ESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQ 236
           AKAKAV+++   SD+SGD+ E+ +  DK+EL +TL+ LS K++DLSTCNDLIAKHG ALQ
Sbjct: 272 AKAKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQ 331

Query: 237 RSLSELESLKLPAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQY 296
           RSL+EL+ LK+P+ES EK+K VNERATLFRITSNAMINACRDFL LA+ HS+KWQ++LQY
Sbjct: 332 RSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQY 391

Query: 297 ERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDEDDE 356
           E++QR+ LEET+EQLAKQHN LERAF  A   PAN   +   G     + KG+ S+ED++
Sbjct: 392 EQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGS--LLTPKGEDSEEDED 449

Query: 357 NEFFDAPE-------IITMPENLGHKRTGS----NISGASSDISLDEQYKHQLEETKKEK 405
            E+FDA E       +IT  +    K  GS    ++  +S+D  LD         +K ++
Sbjct: 450 TEYFDAMEDSTSFITVITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKR 509

Query: 406 RTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAK 465
           R RIP KPNYSLNLWSIMKNCIG+ELS+IPMPVNFNEPLSMLQRLTEDLEYH LLD+A  
Sbjct: 510 RVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVH 569

Query: 466 CENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPP 525
           C +S+EQ+C VAAF+VSSYSTTV R +KPFNP+LGETFELDRL++ G RSLCEQVSHHPP
Sbjct: 570 CTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPP 629

Query: 526 AAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNI 585
           +AAH+  SK+GW+L QEI I+SKFRGKY+SIMPLG IH  F A+G+HY W+K T+TVHNI
Sbjct: 630 SAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNI 689

Query: 586 IVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGT 645
           IVGKLWIDQSG+I+IVNHKT D+C LKF+PYSYFS++ ARKVTG V+D  GK H+ L G+
Sbjct: 690 IVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGS 749

Query: 646 WDEKMECFKVQPVIGEN-GGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLN 704
           WDE+MEC KV      +   D +Q+      S  +LWK+ PLP+NAENMYYFSELALTLN
Sbjct: 750 WDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLN 809

Query: 705 AWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKR-EA---EAMKATED 760
             E G APTDSRLRPDQRLME GRWDEAN EKQRLEEKQRLSR++R EA    +  ++E+
Sbjct: 810 EHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEE 869

Query: 761 GTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSSCPDIF 807
               D Y  LWFE++ DP+T E+  +Y+G YWE KEKQDW  CP+IF
Sbjct: 870 EKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF 916


>gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo
           sapiens]
          Length = 950

 Score =  331 bits (848), Expect = 2e-90
 Identities = 258/770 (33%), Positives = 372/770 (48%), Gaps = 112/770 (14%)

Query: 92  EGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTC--RGTINLATANITVE--DSC 147
           EG L+K + +  G++  W VL +G+LS+YR + +  H    +G  +L  A  TV+  DSC
Sbjct: 239 EGPLWKSSRFF-GWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSC 297

Query: 148 NFIISNGGAQTYHL---KASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDK 204
            F I       +     K S +  R+ W+ A+E   A +    ++ D+  DEE       
Sbjct: 298 LFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQ-DQLTDEEEEDTVSA 356

Query: 205 TELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESN-EKIKQVNERAT 263
            +L+ +L       E   +C   + +  +   + + E +  K    S  +K++ V+E   
Sbjct: 357 ADLKKSL-------EKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSE--- 406

Query: 264 LFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFR 323
                S     A  D L L           L+ E+++   L E LE LA +H+ LE++  
Sbjct: 407 ----ASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQS-- 460

Query: 324 GATVLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISG 383
              ++  + P ++ S                 E+EF+DA        +L      +  S 
Sbjct: 461 ---LVKGSPPASILS-----------------EDEFYDALSDSESERSLSRLEAVTARSF 500

Query: 384 ASSDISLDEQYKHQLEETK------------KEKRTRIPYKPNYSLN---LWSIMKNCIG 428
                 L  + KH++ E K            K+ RT +P  P +S N   +WSI++ CIG
Sbjct: 501 EEEGEHLGSR-KHRMSEEKDCGGGDALSNGIKKHRTSLP-SPMFSRNDFSIWSILRKCIG 558

Query: 429 KELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTV 488
            ELSKI MPV FNEPLS LQRLTE +E+  L+ +A+   + +E++  VAAF VS+ ++  
Sbjct: 559 MELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQW 618

Query: 489 FRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAES-KNGWTLRQEIKITS 547
            RT KPFNPLLGET+EL R ++ G+R + EQVSHHPP +A HAE   N +     I    
Sbjct: 619 ERTGKPFNPLLGETYELVR-DDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKL 677

Query: 548 KFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGD 607
           KF GK +   P GTI          YTW   T  VHNIIVGKLWI+Q G ++I+NHKTGD
Sbjct: 678 KFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGD 737

Query: 608 KCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVI-------- 659
           KC L F P   F +++  KV G + D S K   AL G W E +  + V P          
Sbjct: 738 KCVLNFKPCGLFGKEL-HKVEGYIQDKSKKKLCALYGKWTECL--YSVDPATFDAYKKND 794

Query: 660 ---GENGGDARQRGHEAE---------------ESRVMLWKRNPLPKNAENMYYFSELAL 701
               E   +++Q     E                  V+LW+  P P N+  MY F+  A+
Sbjct: 795 KKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAM 854

Query: 702 TLNA----WESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKA 757
            LN      ES    TD RLRPD R MENG  D+A+ EK+RLEEKQR +RK R     K+
Sbjct: 855 VLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRS----KS 910

Query: 758 TEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSSCPDIF 807
            ED      +K  WF +  +P       IY G YW+    +++ + PDI+
Sbjct: 911 EED------WKTRWFHQGPNPYNGAQDWIYSGSYWD----RNYFNLPDIY 950


>gi|21735584 oxysterol-binding protein-like protein 3 isoform d
           [Homo sapiens]
          Length = 820

 Score =  310 bits (794), Expect = 3e-84
 Identities = 225/747 (30%), Positives = 363/747 (48%), Gaps = 109/747 (14%)

Query: 91  REGWLFKWTNY-IKGYQRRWFVLSNGLLSYYRSKAEM-RHTCRGTINLATANITVEDSCN 148
           ++G+L K   + +KG+ +R+F L  G+L Y +S+ ++ R    G I++  + ++V+ S  
Sbjct: 54  QKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSK 113

Query: 149 FIISNGGAQTYHLKASSEVERQRWVTALE---LAKAKAVKMLAES------------DES 193
            I  +     YHLK  SE     WV+ L    + +   + M                  S
Sbjct: 114 CIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHRMYRQNEIAMFPHEVNHFFSGSTITDSSS 173

Query: 194 GDEESVSQTDKTEL--QNTLRTLSSKV-----------------------EDLSTCNDLI 228
           G  +S+S   ++ +  QN  +T S+                         +DL+ C+  +
Sbjct: 174 GVFDSISSRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSEDMEKCSKDLAHCHAYL 233

Query: 229 AKHGTALQR--------SLSELESLKLPAESNEKIKQVNERATLFRI------------- 267
            +    LQ         S   + ++++P   +  ++  +    L  +             
Sbjct: 234 VEMSQLLQSMDVLHRTYSAPAINAIQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSE 293

Query: 268 TSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGATV 327
           TS+       D   +A       + +      +R +L++ +EQ A      +        
Sbjct: 294 TSSEFSKMQEDLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQ-VIGLKNA 352

Query: 328 LPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTG--SNISGAS 385
           L +    +         S +  +S  D  +EFFDA E++  P +  ++ +   S +S  S
Sbjct: 353 LSSENSRDENRALVHQLSNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDIS 412

Query: 386 SDISLD------EQYKHQL-------EETKKEKRTRIPYK--PNYSLNLWSIMKNCIGKE 430
            ++SLD      +  +  L        E K  +RT +P     + +++LW+I++N IGK+
Sbjct: 413 DNLSLDNLSNDLDNERQTLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKD 472

Query: 431 LSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFR 490
           LSK+ MPV  NEPL+ LQRL E+LEY ELLD+AA+  + LE++ YVAAF +S+Y+++ +R
Sbjct: 473 LSKVAMPVELNEPLNTLQRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYR 532

Query: 491 T-SKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKF 549
             SKPFNP+LGET+E  R E+ G++   EQVSHHPP +A HAES+N +   Q+++  +KF
Sbjct: 533 AGSKPFNPVLGETYECIR-EDKGFQFFSEQVSHHPPISACHAESRN-FVFWQDVRWKNKF 590

Query: 550 RGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVN-HKTGDK 608
            GK + I+P+GT H      G H+ W KVT+ +HNI+ G+ WI+  GEI I N H     
Sbjct: 591 WGKSMEIVPIGTTHVTLPVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCY 650

Query: 609 CNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQ 668
           C + F+   Y+S + A ++ G V D SGK    L G W E + C          GG    
Sbjct: 651 CKVNFIKAKYWSTN-AHEIEGTVFDRSGKAVHRLFGKWHESIYC---------GGG---- 696

Query: 669 RGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGT----APTDSRLRPDQRLM 724
                  S   +W+ NP+PK  E  Y F++ AL LN  +  +     PTD+R RPDQR +
Sbjct: 697 ------SSSACVWRANPMPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFL 750

Query: 725 ENGRWDEANAEKQRLEEKQRLSRKKRE 751
           E G  +EA  +KQR+E+ QR  R+  E
Sbjct: 751 EEGNLEEAEIQKQRIEQLQRERRRVLE 777


>gi|21735582 oxysterol-binding protein-like protein 3 isoform c
           [Homo sapiens]
          Length = 851

 Score =  293 bits (750), Expect = 4e-79
 Identities = 171/430 (39%), Positives = 251/430 (58%), Gaps = 45/430 (10%)

Query: 345 SGKGDMSDEDDENEFFDAPEIITMPENLGHKRTG--SNISGASSDISLD------EQYKH 396
           S +  +S  D  +EFFDA E++  P +  ++ +   S +S  S ++SLD      +  + 
Sbjct: 401 SNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQ 460

Query: 397 QL-------EETKKEKRTRIPYK--PNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSML 447
            L        E K  +RT +P     + +++LW+I++N IGK+LSK+ MPV  NEPL+ L
Sbjct: 461 TLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTL 520

Query: 448 QRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRT-SKPFNPLLGETFELD 506
           QRL E+LEY ELLD+AA+  + LE++ YVAAF +S+Y+++ +R  SKPFNP+LGET+E  
Sbjct: 521 QRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECI 580

Query: 507 RLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIF 566
           R E+ G++   EQVSHHPP +A HAES+N +   Q+++  +KF GK + I+P+GT H   
Sbjct: 581 R-EDKGFQFFSEQVSHHPPISACHAESRN-FVFWQDVRWKNKFWGKSMEIVPIGTTHVTL 638

Query: 567 HATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVN-HKTGDKCNLKFVPYSYFSRDVAR 625
              G H+ W KVT+ +HNI+ G+ WI+  GEI I N H     C + F+   Y+S + A 
Sbjct: 639 PVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTN-AH 697

Query: 626 KVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNP 685
           ++ G V D SGK    L G W E + C          GG           S   +W+ NP
Sbjct: 698 EIEGTVFDRSGKAVHRLFGKWHESIYC---------GGG----------SSSACVWRANP 738

Query: 686 LPKNAENMYYFSELALTLNAWESGT----APTDSRLRPDQRLMENGRWDEANAEKQRLEE 741
           +PK  E  Y F++ AL LN  +  +     PTD+R RPDQR +E G  +EA  +KQR+E+
Sbjct: 739 MPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQ 798

Query: 742 KQRLSRKKRE 751
            QR  R+  E
Sbjct: 799 LQRERRRVLE 808



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 27/88 (30%), Positives = 48/88 (54%), Gaps = 2/88 (2%)

Query: 91  REGWLFKWTNY-IKGYQRRWFVLSNGLLSYYRSKAEM-RHTCRGTINLATANITVEDSCN 148
           ++G+L K   + +KG+ +R+F L  G+L Y +S+ ++ R    G I++  + ++V+ S  
Sbjct: 54  QKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSK 113

Query: 149 FIISNGGAQTYHLKASSEVERQRWVTAL 176
            I  +     YHLK  SE     WV+ L
Sbjct: 114 CIDLDTEEHIYHLKVKSEEVFDEWVSKL 141


>gi|21735580 oxysterol-binding protein-like protein 3 isoform b
           [Homo sapiens]
          Length = 856

 Score =  293 bits (750), Expect = 4e-79
 Identities = 171/430 (39%), Positives = 251/430 (58%), Gaps = 45/430 (10%)

Query: 345 SGKGDMSDEDDENEFFDAPEIITMPENLGHKRTG--SNISGASSDISLD------EQYKH 396
           S +  +S  D  +EFFDA E++  P +  ++ +   S +S  S ++SLD      +  + 
Sbjct: 406 SNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQ 465

Query: 397 QL-------EETKKEKRTRIPYK--PNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSML 447
            L        E K  +RT +P     + +++LW+I++N IGK+LSK+ MPV  NEPL+ L
Sbjct: 466 TLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTL 525

Query: 448 QRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRT-SKPFNPLLGETFELD 506
           QRL E+LEY ELLD+AA+  + LE++ YVAAF +S+Y+++ +R  SKPFNP+LGET+E  
Sbjct: 526 QRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECI 585

Query: 507 RLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIF 566
           R E+ G++   EQVSHHPP +A HAES+N +   Q+++  +KF GK + I+P+GT H   
Sbjct: 586 R-EDKGFQFFSEQVSHHPPISACHAESRN-FVFWQDVRWKNKFWGKSMEIVPIGTTHVTL 643

Query: 567 HATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVN-HKTGDKCNLKFVPYSYFSRDVAR 625
              G H+ W KVT+ +HNI+ G+ WI+  GEI I N H     C + F+   Y+S + A 
Sbjct: 644 PVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTN-AH 702

Query: 626 KVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNP 685
           ++ G V D SGK    L G W E + C          GG           S   +W+ NP
Sbjct: 703 EIEGTVFDRSGKAVHRLFGKWHESIYC---------GGG----------SSSACVWRANP 743

Query: 686 LPKNAENMYYFSELALTLNAWESGT----APTDSRLRPDQRLMENGRWDEANAEKQRLEE 741
           +PK  E  Y F++ AL LN  +  +     PTD+R RPDQR +E G  +EA  +KQR+E+
Sbjct: 744 MPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQ 803

Query: 742 KQRLSRKKRE 751
            QR  R+  E
Sbjct: 804 LQRERRRVLE 813



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 27/88 (30%), Positives = 48/88 (54%), Gaps = 2/88 (2%)

Query: 91  REGWLFKWTNY-IKGYQRRWFVLSNGLLSYYRSKAEM-RHTCRGTINLATANITVEDSCN 148
           ++G+L K   + +KG+ +R+F L  G+L Y +S+ ++ R    G I++  + ++V+ S  
Sbjct: 54  QKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSK 113

Query: 149 FIISNGGAQTYHLKASSEVERQRWVTAL 176
            I  +     YHLK  SE     WV+ L
Sbjct: 114 CIDLDTEEHIYHLKVKSEEVFDEWVSKL 141


>gi|14149704 oxysterol-binding protein-like protein 3 isoform a
           [Homo sapiens]
          Length = 887

 Score =  293 bits (750), Expect = 4e-79
 Identities = 171/430 (39%), Positives = 251/430 (58%), Gaps = 45/430 (10%)

Query: 345 SGKGDMSDEDDENEFFDAPEIITMPENLGHKRTG--SNISGASSDISLD------EQYKH 396
           S +  +S  D  +EFFDA E++  P +  ++ +   S +S  S ++SLD      +  + 
Sbjct: 437 SNESRLSITDSLSEFFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQ 496

Query: 397 QL-------EETKKEKRTRIPYK--PNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSML 447
            L        E K  +RT +P     + +++LW+I++N IGK+LSK+ MPV  NEPL+ L
Sbjct: 497 TLGPVLDSGREAKSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTL 556

Query: 448 QRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRT-SKPFNPLLGETFELD 506
           QRL E+LEY ELLD+AA+  + LE++ YVAAF +S+Y+++ +R  SKPFNP+LGET+E  
Sbjct: 557 QRLCEELEYSELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECI 616

Query: 507 RLEENGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIF 566
           R E+ G++   EQVSHHPP +A HAES+N +   Q+++  +KF GK + I+P+GT H   
Sbjct: 617 R-EDKGFQFFSEQVSHHPPISACHAESRN-FVFWQDVRWKNKFWGKSMEIVPIGTTHVTL 674

Query: 567 HATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVN-HKTGDKCNLKFVPYSYFSRDVAR 625
              G H+ W KVT+ +HNI+ G+ WI+  GEI I N H     C + F+   Y+S + A 
Sbjct: 675 PVFGDHFEWNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTN-AH 733

Query: 626 KVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNP 685
           ++ G V D SGK    L G W E + C          GG           S   +W+ NP
Sbjct: 734 EIEGTVFDRSGKAVHRLFGKWHESIYC---------GGG----------SSSACVWRANP 774

Query: 686 LPKNAENMYYFSELALTLNAWESGT----APTDSRLRPDQRLMENGRWDEANAEKQRLEE 741
           +PK  E  Y F++ AL LN  +  +     PTD+R RPDQR +E G  +EA  +KQR+E+
Sbjct: 775 MPKGYEQYYSFTQFALELNEMDPSSKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQ 834

Query: 742 KQRLSRKKRE 751
            QR  R+  E
Sbjct: 835 LQRERRRVLE 844



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 27/88 (30%), Positives = 48/88 (54%), Gaps = 2/88 (2%)

Query: 91  REGWLFKWTNY-IKGYQRRWFVLSNGLLSYYRSKAEM-RHTCRGTINLATANITVEDSCN 148
           ++G+L K   + +KG+ +R+F L  G+L Y +S+ ++ R    G I++  + ++V+ S  
Sbjct: 54  QKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVGLSVMSVKKSSK 113

Query: 149 FIISNGGAQTYHLKASSEVERQRWVTAL 176
            I  +     YHLK  SE     WV+ L
Sbjct: 114 CIDLDTEEHIYHLKVKSEEVFDEWVSKL 141


>gi|19718746 oxysterol-binding protein-like 1A isoform A [Homo
           sapiens]
          Length = 437

 Score =  290 bits (742), Expect = 4e-78
 Identities = 183/439 (41%), Positives = 241/439 (54%), Gaps = 53/439 (12%)

Query: 403 KEKRTRIPYKPNYSLN---LWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHEL 459
           K+ RT +P  P +S N   +WSI++ CIG ELSKI MPV FNEPLS LQRLTE +E+  L
Sbjct: 18  KKHRTSLP-SPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYL 76

Query: 460 LDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQ 519
           + +A+   + +E++  VAAF VS+ ++   RT KPFNPLLGET+EL R ++ G+R + EQ
Sbjct: 77  IHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVR-DDLGFRLISEQ 135

Query: 520 VSHHPPAAAHHAES-KNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKV 578
           VSHHPP +A HAE   N +     I    KF GK +   P GTI          YTW   
Sbjct: 136 VSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNP 195

Query: 579 TTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKV 638
           T  VHNIIVGKLWI+Q G ++I+NHKTGDKC L F P   F +++  KV G + D S K 
Sbjct: 196 TCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKEL-HKVEGYIQDKSKKK 254

Query: 639 HFALLGTWDEKMECFKVQPVI-----------GENGGDARQRGHEAE------------- 674
             AL G W E +  + V P              E   +++Q     E             
Sbjct: 255 LCALYGKWTECL--YSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVF 312

Query: 675 --ESRVMLWKRNPLPKNAENMYYFSELALTLNA----WESGTAPTDSRLRPDQRLMENGR 728
                V+LW+  P P N+  MY F+  A+ LN      ES    TD RLRPD R MENG 
Sbjct: 313 IIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGE 372

Query: 729 WDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYR 788
            D+A+ EK+RLEEKQR +RK R     K+ ED      +K  WF +  +P       IY 
Sbjct: 373 IDQASEEKKRLEEKQRAARKNRS----KSEED------WKTRWFHQGPNPYNGAQDWIYS 422

Query: 789 GEYWECKEKQDWSSCPDIF 807
           G YW+    +++ + PDI+
Sbjct: 423 GSYWD----RNYFNLPDIY 437


>gi|21450853 oxysterol-binding protein-like protein 2 isoform 2
           [Homo sapiens]
          Length = 480

 Score =  282 bits (722), Expect = 8e-76
 Identities = 183/499 (36%), Positives = 263/499 (52%), Gaps = 69/499 (13%)

Query: 356 ENEFFDAPEIITMPENLGH-KRTGSNISGASSDISLDEQYKHQLEETKK---------EK 405
           E EFFDA        + G        ++G    I LD    +++ +T +         + 
Sbjct: 4   EEEFFDAVTGFDSDNSSGEFSEANQKVTGM---IDLDTSKNNRIGKTGERPSQENGIQKH 60

Query: 406 RTRIPYKPNYS---LNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDR 462
           RT +P  P +S    ++W+I+K C+G ELSKI MP+ FNEPLS LQR+TE +E+  L+ R
Sbjct: 61  RTSLP-APMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHR 119

Query: 463 AAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSH 522
           A+     LE++  VAAF VS+ ++   RT KPFNPLLGET+EL R E+ G+R + EQVSH
Sbjct: 120 ASCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIR-EDLGFRFISEQVSH 178

Query: 523 HPPAAAHHAESKN-GWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTT 581
           HPP +A H+E  N  +     I    KF GK +   P GTI          YTW   T  
Sbjct: 179 HPPISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCC 238

Query: 582 VHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFA 641
           VHN+I+GKLWI+Q G ++I+NH+TG KC L F P   F +++  KV G + D + K  F 
Sbjct: 239 VHNVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKEL-HKVEGHIQDKNKKKLFM 297

Query: 642 LLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRV----------------------- 678
           + G W E +  + + PV  E+     +RG    ++++                       
Sbjct: 298 IYGKWTECL--WGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQ 355

Query: 679 ------MLWKRNPLPKNAENMYYFSELALTLNAWESGTA----PTDSRLRPDQRLMENGR 728
                 +LW+ N  P N+  MY F+   ++LN  E+G      PTD RLRPD R MENG 
Sbjct: 356 VIPGSKLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGN 415

Query: 729 WDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYR 788
            D A+ EK+RLEEKQR +R++R  E  +          ++  WF    +P T     +Y 
Sbjct: 416 MDLASQEKERLEEKQREARRERAKEEAE----------WQTRWFYPGNNPYTGTPDWLYA 465

Query: 789 GEYWECKEKQDWSSCPDIF 807
           G+Y+E    +++S CPDI+
Sbjct: 466 GDYFE----RNFSDCPDIY 480


>gi|7662298 oxysterol-binding protein-like protein 2 isoform 1 [Homo
           sapiens]
          Length = 468

 Score =  282 bits (722), Expect = 8e-76
 Identities = 183/490 (37%), Positives = 260/490 (53%), Gaps = 63/490 (12%)

Query: 356 ENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEK-RTRIPYKPN 414
           E EFFDA            K TG      S +  + +  +   +E   +K RT +P  P 
Sbjct: 4   EEEFFDAVT------EANQKVTGMIDLDTSKNNRIGKTGERPSQENGIQKHRTSLP-APM 56

Query: 415 YS---LNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLE 471
           +S    ++W+I+K C+G ELSKI MP+ FNEPLS LQR+TE +E+  L+ RA+     LE
Sbjct: 57  FSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRASCQPQPLE 116

Query: 472 QLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFELDRLEENGYRSLCEQVSHHPPAAAHHA 531
           ++  VAAF VS+ ++   RT KPFNPLLGET+EL R E+ G+R + EQVSHHPP +A H+
Sbjct: 117 RMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIR-EDLGFRFISEQVSHHPPISAFHS 175

Query: 532 ESKN-GWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKL 590
           E  N  +     I    KF GK +   P GTI          YTW   T  VHN+I+GKL
Sbjct: 176 EGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVIIGKL 235

Query: 591 WIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHFALLGTWDEKM 650
           WI+Q G ++I+NH+TG KC L F P   F +++  KV G + D + K  F + G W E +
Sbjct: 236 WIEQYGTVEILNHRTGHKCVLHFKPCGLFGKEL-HKVEGHIQDKNKKKLFMIYGKWTECL 294

Query: 651 ECFKVQPVIGENGGDARQRGHEAEESRV-----------------------------MLW 681
             + + PV  E+     +RG    ++++                             +LW
Sbjct: 295 --WGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGSKLLW 352

Query: 682 KRNPLPKNAENMYYFSELALTLNAWESGTA----PTDSRLRPDQRLMENGRWDEANAEKQ 737
           + N  P N+  MY F+   ++LN  E+G      PTD RLRPD R MENG  D A+ EK+
Sbjct: 353 RINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKE 412

Query: 738 RLEEKQRLSRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEK 797
           RLEEKQR +R++R  E  +          ++  WF    +P T     +Y G+Y+E    
Sbjct: 413 RLEEKQREARRERAKEEAE----------WQTRWFYPGNNPYTGTPDWLYAGDYFE---- 458

Query: 798 QDWSSCPDIF 807
           +++S CPDI+
Sbjct: 459 RNFSDCPDIY 468


>gi|14210532 oxysterol-binding protein-like protein 6 isoform a
           [Homo sapiens]
          Length = 934

 Score =  270 bits (690), Expect = 4e-72
 Identities = 207/647 (31%), Positives = 318/647 (49%), Gaps = 80/647 (12%)

Query: 197 ESVSQTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIK 256
           +SVS+  K +LQ       S V   S+  +L A      Q   S L     P ES+    
Sbjct: 318 KSVSKDTKIQLQVPFSATMSPVRLHSSNPNLCAD--IEFQTPPSHLTD---PLESSTDYT 372

Query: 257 QVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERD---QRIRLEETLEQLAK 313
           ++ E   L     ++++ +  + + + +   K+      + +    Q  RL ++L Q   
Sbjct: 373 KLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALN 432

Query: 314 QHNHLERAFR-------------GATVLP----ANTPGNVGSGKDQCCSGKGDMSDEDDE 356
           Q+  L                     ++P    A    +V     Q  + +  +S  +  
Sbjct: 433 QNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESV 492

Query: 357 NEFFDAPEIITMPENLGHKRTG--SNISGASSDISLD-----EQYKHQL---EET----K 402
           +EFFDA E++    +  ++ +   S IS  S +IS D     +    Q+   E T    +
Sbjct: 493 SEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFR 552

Query: 403 KEKRTRIPYK-PNYS-LNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELL 460
             +R  +P   P+ S +NLW+I++N IGK+LSK+ MPV  NEPL+ LQ L E++EY ELL
Sbjct: 553 NGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELL 612

Query: 461 DRAAKCENSLEQLCYVAAFTVSSYSTTVFRT-SKPFNPLLGETFELDRLEENGYRSLCEQ 519
           D+A++ ++  E++  VAAF VS Y +T FR  SKPFNP+LGET+E  R E+ G+R   EQ
Sbjct: 613 DKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIR-EDKGFRFFSEQ 671

Query: 520 VSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVT 579
           VSHHPP +A H ESKN +   Q+I+  +KF GK + I+P+GT++ +    G +Y W KVT
Sbjct: 672 VSHHPPISACHCESKN-FVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVT 730

Query: 580 TTVHNIIVGKLWIDQSGEIDIVNHKTG-DKCNLKFVPYSYFSRDVARKVTGEVTDPSGKV 638
           T +HNI+ G+ WI+  GE+ I N K+    C L FV  +Y++ ++  +V G V D  GK 
Sbjct: 731 TCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNM-NEVQGVVIDQEGKA 789

Query: 639 HFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSE 698
            + L G W E + C  V P                  S   +W+   +P N E  Y F+ 
Sbjct: 790 VYRLFGKWHEGLYC-GVAP------------------SAKCIWRPGSMPTNYELYYGFTR 830

Query: 699 LALTLN----AWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEA 754
            A+ LN      +    PTD+R RPDQR +E G  + A +EKQR+EE QR  R+  E   
Sbjct: 831 FAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYME--- 887

Query: 755 MKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWS 801
               E+   + P     F +K     +    +    YWE ++   +S
Sbjct: 888 ----ENNLEHIPK----FFKKVIDANQREAWVSNDTYWELRKDPGFS 926



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 24/87 (27%), Positives = 48/87 (55%), Gaps = 2/87 (2%)

Query: 92  EGWLFKWTNY-IKGYQRRWFVLSNGLLSYYRSKAEM-RHTCRGTINLATANITVEDSCNF 149
           EG++ K   + +KG+ +R+FVL NG+L Y ++  ++ +    G+I++  + ++++     
Sbjct: 90  EGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARR 149

Query: 150 IISNGGAQTYHLKASSEVERQRWVTAL 176
           I  +     YHLK  S+     WV+ L
Sbjct: 150 IDLDTEEHIYHLKVKSQDWFDAWVSKL 176


>gi|22035612 oxysterol-binding protein-like protein 6 isoform b
           [Homo sapiens]
          Length = 938

 Score =  268 bits (685), Expect = 1e-71
 Identities = 193/596 (32%), Positives = 299/596 (50%), Gaps = 75/596 (12%)

Query: 248 PAESNEKIKQVNERATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERD---QRIRL 304
           P ES+    ++ E   L     ++++ +  + + + +   K+      + +    Q  RL
Sbjct: 368 PLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARL 427

Query: 305 EETLEQLAKQHNHLERAFR-------------GATVLP----ANTPGNVGSGKDQCCSGK 347
            ++L Q   Q+  L                     ++P    A    +V     Q  + +
Sbjct: 428 RQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANE 487

Query: 348 GDMSDEDDENEFFDAPEIITMPENLGHKRTG--SNISGASSDISLD-----EQYKHQL-- 398
             +S  +  +EFFDA E++    +  ++ +   S IS  S +IS D     +    Q+  
Sbjct: 488 SRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILN 547

Query: 399 -EET----KKEKRTRIPYK-PNYS-LNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLT 451
            E T    +  +R  +P   P+ S +NLW+I++N IGK+LSK+ MPV  NEPL+ LQ L 
Sbjct: 548 GELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLC 607

Query: 452 EDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRT-SKPFNPLLGETFELDRLEE 510
           E++EY ELLD+A++ ++  E++  VAAF VS Y +T FR  SKPFNP+LGET+E  R E+
Sbjct: 608 EEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIR-ED 666

Query: 511 NGYRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATG 570
            G+R   EQVSHHPP +A H ESKN +   Q+I+  +KF GK + I+P+GT++ +    G
Sbjct: 667 KGFRFFSEQVSHHPPISACHCESKN-FVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYG 725

Query: 571 HHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTG-DKCNLKFVPYSYFSRDVARKVTG 629
            +Y W KVTT +HNI+ G+ WI+  GE+ I N K+    C L FV  +Y++ ++  +V G
Sbjct: 726 DYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNM-NEVQG 784

Query: 630 EVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKN 689
            V D  GK  + L G W E + C  V P                  S   +W+   +P N
Sbjct: 785 VVIDQEGKAVYRLFGKWHEGLYC-GVAP------------------SAKCIWRPGSMPTN 825

Query: 690 AENMYYFSELALTLN----AWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRL 745
            E  Y F+  A+ LN      +    PTD+R RPDQR +E G  + A +EKQR+EE QR 
Sbjct: 826 YELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRS 885

Query: 746 SRKKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWS 801
            R+  E       E+   + P     F +K     +    +    YWE ++   +S
Sbjct: 886 RRRYME-------ENNLEHIPK----FFKKVIDANQREAWVSNDTYWELRKDPGFS 930



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 24/87 (27%), Positives = 48/87 (55%), Gaps = 2/87 (2%)

Query: 92  EGWLFKWTNY-IKGYQRRWFVLSNGLLSYYRSKAEM-RHTCRGTINLATANITVEDSCNF 149
           EG++ K   + +KG+ +R+FVL NG+L Y ++  ++ +    G+I++  + ++++     
Sbjct: 69  EGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARR 128

Query: 150 IISNGGAQTYHLKASSEVERQRWVTAL 176
           I  +     YHLK  S+     WV+ L
Sbjct: 129 IDLDTEEHIYHLKVKSQDWFDAWVSKL 155


>gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens]
          Length = 842

 Score =  257 bits (657), Expect = 3e-68
 Identities = 168/475 (35%), Positives = 252/475 (53%), Gaps = 55/475 (11%)

Query: 350 MSDEDDENEFFDAPEII---TMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKK--- 403
           +S  D   EFFDA E++   +  EN G +   S  S  ++ +S +       E  +K   
Sbjct: 394 LSLADSHTEFFDACEVLLSASSSENEGSEEEESCTSEITTSLSEEMLDLRGAERCQKGGC 453

Query: 404 --------EKRTRIPYK--PNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTED 453
                    +R  +P    P   ++LW+I++N IGK+LSK+ MPV  NEPL+ LQRL E+
Sbjct: 454 VPGRPMGPPRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQRLCEE 513

Query: 454 LEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTS-KPFNPLLGETFELDRLEENG 512
           LEY  LLD+A++  +  E++ Y+AAF VS+YS+T  R   KPFNP+LGET+E +R  + G
Sbjct: 514 LEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYECER-PDRG 572

Query: 513 YRSLCEQVSHHPPAAAHHAESKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHH 572
           +R + EQVSHHPP +A HAES+N +   Q++K  +KF GK L I+P+GT++      G H
Sbjct: 573 FRFISEQVSHHPPISACHAESEN-FAFWQDMKWKNKFWGKSLEIVPVGTVNVSLPRFGDH 631

Query: 573 YTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGD-KCNLKFVPYSYFSRDVARKVTGEV 631
           + W KVT+ +HN++ G+ WI+  GE+ I N +     C + F    Y+S +V  +V G V
Sbjct: 632 FEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSNV-HEVQGAV 690

Query: 632 TDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAE 691
              SG+V   L G W E +                  RG         +WK N +P + E
Sbjct: 691 LSRSGRVLHRLFGKWHEGL-----------------YRG--PTPGGQCIWKPNSMPPDHE 731

Query: 692 NMYYFSELALTLN----AWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSR 747
             + F++ AL LN      +     TD+RLRPDQR +E G    A A+K+R+E+ QR  R
Sbjct: 732 RNFGFTQFALELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRR 791

Query: 748 KKREAEAMKATEDGTPYDPYKALWFERKKDPVTKELTHIYRGEYWECKEKQDWSS 802
           K  E   +           ++A +F R+ D   KE   +    YW  + +  + +
Sbjct: 792 KVMEENNI----------VHQARFFRRQTDSSGKE-WWVTNNTYWRLRAEPGYGN 835



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 25/88 (28%), Positives = 47/88 (53%), Gaps = 2/88 (2%)

Query: 91  REGWLFKWTNY-IKGYQRRWFVLSNGLLSYYRSKAEM-RHTCRGTINLATANITVEDSCN 148
           +EG L K   + +KG+ +R+FVL +G+L Y  ++ ++ +    G+I++  + +++     
Sbjct: 50  QEGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINKKAQ 109

Query: 149 FIISNGGAQTYHLKASSEVERQRWVTAL 176
            I  +     YHLK  S+   Q WV  L
Sbjct: 110 RIDLDTEDNIYHLKIKSQDLFQSWVAQL 137


>gi|20070331 oxysterol binding protein-like 9 isoform e [Homo
           sapiens]
          Length = 736

 Score =  115 bits (288), Expect = 2e-25
 Identities = 187/782 (23%), Positives = 307/782 (39%), Gaps = 175/782 (22%)

Query: 89  SAREGWLFKWTNYIKGYQRRWFVL--SNGLLSYYRSKAE-MRHTCRGTINL--ATANITV 143
           S  EG L KWTN +KG+Q RWFVL  + GLLSYY SK + MR + RG + L  A   I  
Sbjct: 3   SIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDD 62

Query: 144 EDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTD 203
           ED   F I+    +T+H +A    ER++W+ ALE    +    L   D SG   SV   D
Sbjct: 63  EDDSTFTIT-VDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLD-SGFVPSVQDFD 120

Query: 204 K--TELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNER 261
           K  TE    L+ L   +E L   +D              +L++ K   E  +KI+ + E 
Sbjct: 121 KKLTEADAYLQIL---IEQLKLFDD--------------KLQNCK-EDEQRKKIETLKE- 161

Query: 262 ATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLE-- 319
                 T+N+M+ + +  ++L Q    K Q + +   D  I     ++ +  Q + LE  
Sbjct: 162 ------TTNSMVESIKHCIVLLQI--AKDQSNAEKHADGMISTINPVDAI-YQPSPLEPV 212

Query: 320 -RAFRGATVLPAN-----------------------------TPGNVGSGKDQCCSG--- 346
                  TVLP                               TP + GSG     S    
Sbjct: 213 ISTMPSQTVLPPEPVQLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTS 272

Query: 347 ----------KGDMSDEDDENEFFDAPEIITMPEN-------------LGHKRTG----- 378
                       + S    E+EF+DA E      +             L H  +G     
Sbjct: 273 PSHVNLSPNTVPEFSYSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKR 332

Query: 379 --------SNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKE 430
                   S++S  +SD  L + +  + ++ +         + + S+ +  + +  +G +
Sbjct: 333 PDTTESLNSSLSNGTSDADLFDSHDDRDDDAEAGS-----VEEHKSVIMHLLSQVRLGMD 387

Query: 431 LSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSY--STTV 488
           L+K+ +P    E  S+L+   +   + +L    +  ++  +++  V  + +S++      
Sbjct: 388 LTKVVLPTFILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKG 447

Query: 489 FRTSKPFNPLLGETFE--------------------LDRLEENGYRSLCEQVSHHPPAAA 528
               KP+NP+LGE F+                    +  + +N    + EQVSHHPP +A
Sbjct: 448 SVAKKPYNPILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISA 507

Query: 529 HHAESKN-GWTLRQEIKITSKFRGKYLSIMPL--GTIHCIFHATGHHYTWKKVTTTVHNI 585
            +AE  N        I   SKF G  + +  +  G + C+ +    HY          +I
Sbjct: 508 FYAECFNKKIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY--DEHYILTFPNGYGRSI 565

Query: 586 IVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHF-ALLG 644
           +    W++  GE +I   KTG   N+ F    ++      ++T E+  P+ K  F ++ G
Sbjct: 566 LTVP-WVELGGECNINCSKTGYSANIIFHTKPFYG-GKKHRITAEIFSPNDKKSFCSIEG 623

Query: 645 TWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLN 704
            W+  M     +   GEN           +  ++ + K+       +N Y    L     
Sbjct: 624 EWNGVM---YAKYATGEN-------TVFVDTKKLPIIKKKVRKLEDQNEYESRSL----- 668

Query: 705 AWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRL-SRKKREAEAMKAT----E 759
            W+  T     R             D A   K RLEE+QR  +R+++E E    T    E
Sbjct: 669 -WKDVTFNLKIR-----------DIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHE 716

Query: 760 DG 761
           DG
Sbjct: 717 DG 718


>gi|22547173 oxysterol binding protein-like 9 isoform d [Homo
           sapiens]
          Length = 723

 Score =  115 bits (287), Expect = 2e-25
 Identities = 185/751 (24%), Positives = 298/751 (39%), Gaps = 126/751 (16%)

Query: 89  SAREGWLFKWTNYIKGYQRRWFVL--SNGLLSYYRSKAE-MRHTCRGTINL--ATANITV 143
           S  EG L KWTN +KG+Q RWFVL  + GLLSYY SK + MR + RG + L  A   I  
Sbjct: 3   SIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDD 62

Query: 144 EDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTD 203
           ED   F I+    +T+H +A    ER++W+ ALE    +    L   D SG   SV   D
Sbjct: 63  EDDSTFTIT-VDQKTFHFQARDADEREKWIHALEETILRHTLQLQGLD-SGFVPSVQDFD 120

Query: 204 K--TELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESN-EKIKQVNE 260
           K  TE    L+ L   +E L   +D +       QR   ++E+LK    S  E IK    
Sbjct: 121 KKLTEADAYLQIL---IEQLKLFDDKLQNCKEDEQR--KKIETLKETTNSMVESIKHCIV 175

Query: 261 RATLFRITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLER 320
              + + T N +    +   +     +   Q  L  E  Q  + E+    L         
Sbjct: 176 LLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPVQLCKSEQRPSSLPVGP---VL 232

Query: 321 AFRGATVLPANTPGNVGSGKDQCCSG-------------KGDMSDEDDENEFFDAPEIIT 367
           A  G    P  TP + GSG     S                + S    E+EF+DA E   
Sbjct: 233 ATLGHHQTP--TPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFSYSSSEDEFYDADEFHQ 290

Query: 368 MPEN-------------LGHKRTG-------------SNISGASSDISLDEQYKHQLEET 401
              +             L H  +G             S++S  +SD  L + +  + ++ 
Sbjct: 291 SGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGTSDADLFDSHDDRDDDA 350

Query: 402 KKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLD 461
           +         + + S+ +  + +  +G +L+K+ +P    E  S+L+   +   + +L  
Sbjct: 351 EAGS-----VEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRSLLEMYADFFAHPDLFV 405

Query: 462 RAAKCENSLEQLCYVAAFTVSSY--STTVFRTSKPFNPLLGETFE--------------- 504
             +  ++  +++  V  + +S++          KP+NP+LGE F+               
Sbjct: 406 SISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIFQCHWTLPNDTEENTEL 465

Query: 505 -----LDRLEENGYRSLCEQVSHHPPAAAHHAESKN-GWTLRQEIKITSKFRGKYLSIMP 558
                +  + +N    + EQVSHHPP +A +AE  N        I   SKF G  + +  
Sbjct: 466 VSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAHIWTKSKFLGMSIGVHN 525

Query: 559 L--GTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPY 616
           +  G + C+ +    HY          +I+    W++  GE +I   KTG   N+ F   
Sbjct: 526 IGQGCVSCLDY--DEHYILTFPNGYGRSILTVP-WVELGGECNINCSKTGYSANIIFHTK 582

Query: 617 SYFSRDVARKVTGEVTDPSGKVHF-ALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEE 675
            ++      ++T E+  P+ K  F ++ G W+  M     +   GEN           + 
Sbjct: 583 PFYG-GKKHRITAEIFSPNDKKSFCSIEGEWNGVM---YAKYATGEN-------TVFVDT 631

Query: 676 SRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAE 735
            ++ + K+       +N Y    L      W+  T     R             D A   
Sbjct: 632 KKLPIIKKKVRKLEDQNEYESRSL------WKDVTFNLKIR-----------DIDAATEA 674

Query: 736 KQRLEEKQRL-SRKKREAEAMKAT----EDG 761
           K RLEE+QR  +R+++E E    T    EDG
Sbjct: 675 KHRLEERQRAEARERKEKEIQWETRLFHEDG 705


>gi|19923592 oxysterol binding protein-like 11 [Homo sapiens]
          Length = 747

 Score =  114 bits (285), Expect = 4e-25
 Identities = 161/790 (20%), Positives = 302/790 (38%), Gaps = 157/790 (19%)

Query: 63  GGVAAAGPAPAPPTGGSGGSGAGGSGSAREGW------------LFKWTNYIKGYQRRWF 110
           G   A  P      GG   S +   G + +GW            L K+TN + G+Q R+F
Sbjct: 21  GQATAVTPNKNSSCGGGISSSSSSRGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFF 80

Query: 111 VLSN--GLLSYYRSKAEMRHTCRGTINLATANITV--EDSCNFIISNGGAQTYHLKASSE 166
           VL+N  GLL Y+ ++       RGT+ LA A I+   EDS  F ++    + Y L+A+  
Sbjct: 81  VLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDA 140

Query: 167 VERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLS----------- 215
            ERQ WV+ L++      + + +++      S S    +    + R  S           
Sbjct: 141 KERQHWVSRLQICTQHHTEAIGKNNPPLKSRSFSLASSSNSPISQRRPSQNAISFFNVGH 200

Query: 216 SKVEDLSTCNDLIAKHGTALQRSLSELESLK---------LPAESNEKIKQVNERATLFR 266
           SK++ LS   +L   H   ++  +S  E  +         LP   +  +  +++   + +
Sbjct: 201 SKLQSLSKRTNLPPDHLVEVREMMSHAEGQQRDLIRRIECLPTSGH--LSSLDQDLLMLK 258

Query: 267 ITSNAMINACRDFLMLAQTHSKKWQKSLQYERDQRIRLEETLEQLAKQHNHLERAFRGAT 326
            TS A +N   D   + Q      QK           LE  +       N  ++ F    
Sbjct: 259 ATSMATMNCLNDCFHILQLQHASHQKGSLPSGTTIEWLEPKISLSNHYKNGADQPFATDQ 318

Query: 327 VLPANTPGNVGSGKDQCCSGKGDMSDEDDENEFFDAPEIITMPENLGHKRTGSNISGASS 386
             P   P      ++Q  +  G ++ E +E                            ++
Sbjct: 319 SKPVAVP------EEQPVAESGLLAREPEE---------------------------INA 345

Query: 387 DISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSM 446
           D  +++   H     K++    +  + +  L+L S +K  +G +L+++ +P    E  S+
Sbjct: 346 DDEIEDTCDH-----KEDDLGAVEEQRSVILHLLSQLK--LGMDLTRVVLPTFILEKRSL 398

Query: 447 LQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSY--STTVFRTSKPFNPLLGETF- 503
           L+   + + + +L         + +++     + ++S+          KP+NP++GETF 
Sbjct: 399 LEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGRKGAIAKKPYNPIIGETFH 458

Query: 504 --------------------------------ELDRLEENGY--RSLCEQVSHHPPAAAH 529
                                            L ++  + Y  R + EQVSHHPP +  
Sbjct: 459 CSWKMPKSEVASSVFSSSSTQGVTNHAPLSGESLTQVGSDCYTVRFVAEQVSHHPPVSGF 518

Query: 530 HAE-SKNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVG 588
           +AE ++    +   +   SKF G  + +  +G         G  YT+        +I+  
Sbjct: 519 YAECTERKMCVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHGEEYTFSLPCAYARSILTV 578

Query: 589 KLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVT-DPSGKVHFALLGTWD 647
             W++  G++ +   KTG   ++ F    ++   + R VT EV  + +  V   + G W+
Sbjct: 579 P-WVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHR-VTAEVKHNITNTVVCRVQGEWN 636

Query: 648 EKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWE 707
             +E          + G+ +      + +++ + K+   P   ++ +    L      W+
Sbjct: 637 SVLE-------FTYSNGETKY----VDLTKLAVTKKRVRPLEKQDPFESRRL------WK 679

Query: 708 SGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRLSRKKREAEAMKATEDGTPYDPY 767
           +    TDS        +     D+A   K  LEE+QR   + R       TE GT   P+
Sbjct: 680 N---VTDS--------LRESEIDKATEHKHTLEERQRTEERHR-------TETGT---PW 718

Query: 768 KALWFERKKD 777
           K  +F ++ D
Sbjct: 719 KTKYFIKEGD 728


>gi|22547176 oxysterol binding protein-like 9 isoform f [Homo
           sapiens]
          Length = 746

 Score =  114 bits (285), Expect = 4e-25
 Identities = 177/767 (23%), Positives = 301/767 (39%), Gaps = 135/767 (17%)

Query: 89  SAREGWLFKWTNYIKGYQRRWFVL--SNGLLSYYRSKAE-MRHTCRGTINL--ATANITV 143
           S  EG L KWTN +KG+Q RWFVL  + GLLSYY SK + MR + RG + L  A   I  
Sbjct: 3   SIMEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDD 62

Query: 144 EDSCNFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTD 203
           ED   F I+    +T+H +A    ER++W+ ALE    +    L  S      +S   + 
Sbjct: 63  EDDSTFTIT-VDQKTFHFQARDADEREKWIHALEETILRHTLQLQISTTLAFFQSSGISP 121

Query: 204 KTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERAT 263
             E    +   S  V  +   +  + +    LQ     +E LKL  +  +  K+  +R  
Sbjct: 122 VLEFSKIIGLDSGFVPSVQDFDKKLTEADAYLQ---ILIEQLKLFDDKLQNCKEDEQRKK 178

Query: 264 L--FRITSNAMINACRDFLMLAQTHSKK-------WQKS-----LQYERDQRIRLEETLE 309
           +   + T+N+M+ + +  ++L Q            +Q S     +     Q +   E + 
Sbjct: 179 IETLKETTNSMVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPPEPV- 237

Query: 310 QLAKQHNHLERAFRGATVLPAN-----TPGNVGSGKDQCCSG-------------KGDMS 351
           QL K          G  +         TP + GSG     S                + S
Sbjct: 238 QLCKSEQRPSSLPVGPVLATLGHHQTPTPNSTGSGHSPPSSSLTSPSHVNLSPNTVPEFS 297

Query: 352 DEDDENEFFDAPEIITMPEN-------------LGHKRTG-------------SNISGAS 385
               E+EF+DA E      +             L H  +G             S++S  +
Sbjct: 298 YSSSEDEFYDADEFHQSGSSPKRLIDSSGSASVLTHSSSGNSLKRPDTTESLNSSLSNGT 357

Query: 386 SDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPVNFNEPLS 445
           SD  L + +  + ++ +         + + S+ +  + +  +G +L+K+ +P    E  S
Sbjct: 358 SDADLFDSHDDRDDDAEAGS-----VEEHKSVIMHLLSQVRLGMDLTKVVLPTFILERRS 412

Query: 446 MLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSY--STTVFRTSKPFNPLLGETF 503
           +L+   +   + +L    +  ++  +++  V  + +S++          KP+NP+LGE F
Sbjct: 413 LLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYNPILGEIF 472

Query: 504 E--------------------LDRLEENGYRSLCEQVSHHPPAAAHHAESKN-GWTLRQE 542
           +                    +  + +N    + EQVSHHPP +A +AE  N        
Sbjct: 473 QCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNKKIQFNAH 532

Query: 543 IKITSKFRGKYLSIMPL--GTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDI 600
           I   SKF G  + +  +  G + C+ +    HY          +I+    W++  GE +I
Sbjct: 533 IWTKSKFLGMSIGVHNIGQGCVSCLDY--DEHYILTFPNGYGRSILTVP-WVELGGECNI 589

Query: 601 VNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHF-ALLGTWDEKMECFKVQPVI 659
              KTG   N+ F    ++      ++T E+  P+ K  F ++ G W+  M     +   
Sbjct: 590 NCSKTGYSANIIFHTKPFYG-GKKHRITAEIFSPNDKKSFCSIEGEWNGVM---YAKYAT 645

Query: 660 GENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRP 719
           GEN           +  ++ + K+       +N Y    L      W+  T     R   
Sbjct: 646 GEN-------TVFVDTKKLPIIKKKVRKLEDQNEYESRSL------WKDVTFNLKIR--- 689

Query: 720 DQRLMENGRWDEANAEKQRLEEKQRL-SRKKREAEAMKAT----EDG 761
                     D A   K RLEE+QR  +R+++E E    T    EDG
Sbjct: 690 --------DIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDG 728


>gi|19923812 oxysterol-binding protein-like protein 10 [Homo
           sapiens]
          Length = 764

 Score =  110 bits (276), Expect = 4e-24
 Identities = 181/797 (22%), Positives = 305/797 (38%), Gaps = 146/797 (18%)

Query: 31  GGGGGRGDAGPGSGAAS-GTVVAAAAGGPG----PGAGGVAAAGPAPAPPTGGSGGSGAG 85
           GGGG    +   S A S G+  + +  G G      A G+   G   +P +  +  SG G
Sbjct: 10  GGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGSVAASPSGGG 69

Query: 86  GSGS--AREGWLFKWTNYIKGYQRRWFVL--SNGLLSYYRSKAEMRHTCRGTINLATANI 141
           G     A EG L K+TN ++G+Q R+FVL    G+L Y+ ++       RG ++L+ A +
Sbjct: 70  GRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIV 129

Query: 142 TVEDSC--NFIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESV 199
           ++ D      ++ +   + + L+A+   E+Q WVT L       ++M ++S  S    S+
Sbjct: 130 SLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKSAPSSRSRSL 189

Query: 200 S----QTDKTELQNTLRTLSSKVEDLSTCNDLIAKHGTALQRS-------LSELESLKLP 248
           +     T  +    + R LS     + T      K   A +R+       L E+  +   
Sbjct: 190 TLLPHGTPNSASPCSQRHLSVGAPGVVTITH--HKSPAAARRAKSQYSGQLHEVREMMNQ 247

Query: 249 AESNEK--------------IKQVNERATLFRITSNAMINACRDFL-MLAQTHSKKWQKS 293
            E  +K              +  +++   L + TS A ++   + L +L Q+  +  Q S
Sbjct: 248 VEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSVHQAGQPS 307

Query: 294 LQYERDQRIRLEETLEQLAKQHNHLERAFRGATVLPANTPGNVGSGKDQCCSGKGDMSDE 353
                 Q+    E +       +H     +  T+      G++ S            S E
Sbjct: 308 ------QKPGASENILGWHGSKSHSTEQLKNGTL------GSLPSASANITWAILPNSAE 355

Query: 354 DDENEFFDAPEIITMPENLGHKRTGSNISGASSDISLDEQYKHQLEETKKEKRTRIPYKP 413
           D++      PE    PE      +GS +   S D   D + K + E    E +  I    
Sbjct: 356 DEQT---SQPE----PE----PNSGSELV-LSEDEKSDNEDKEETELGVMEDQRSI---- 399

Query: 414 NYSLNLWSIMKNCIGKELSKIPMPVNFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQ- 472
              L+L S +K  +G +L+K+ +P    E  S+L+   + + + +LL          E+ 
Sbjct: 400 --ILHLISQLK--LGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERV 455

Query: 473 LCYVAAFTVSSYSTTVFR-------TSKPFNPLLGETFEL-------------------- 505
           +C+V       Y  T F          KP+NP++GETF                      
Sbjct: 456 ICFV------EYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPA 509

Query: 506 ---------DRLEENGYRSLCEQVSHHPPAAAHHAE-SKNGWTLRQEIKITSKFRGKYLS 555
                    D  +    R + EQVSHHPP +  + E  +    +   +   SKF G  + 
Sbjct: 510 SCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVG 569

Query: 556 IMPLGTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVP 615
           +  +G         G  Y +   +    +I+    W++  G++ I   KTG    + F  
Sbjct: 570 VSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIP-WVELGGKVSINCAKTGYSATVIFHT 628

Query: 616 YSYFSRDVARKVTGEVT-DPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAE 674
             ++   V R VT EV  +P+  +     G W+  +E          N G+ +    +  
Sbjct: 629 KPFYGGKVHR-VTAEVKHNPTNTIVCKAHGEWNGTLE-------FTYNNGETKV--IDTT 678

Query: 675 ESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANA 734
              V   K  PL K             + N W   T           R +  G  D A  
Sbjct: 679 TLPVYPKKIRPLEKQGP--------MESRNLWREVT-----------RYLRLGDIDAATE 719

Query: 735 EKQRLEEKQRLSRKKRE 751
           +K+ LEEKQR+  +KRE
Sbjct: 720 QKRHLEEKQRVEERKRE 736


>gi|14149740 oxysterol-binding protein-like protein 5 isoform a
           [Homo sapiens]
          Length = 879

 Score =  102 bits (255), Expect = 1e-21
 Identities = 97/392 (24%), Positives = 166/392 (42%), Gaps = 31/392 (7%)

Query: 392 EQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCI-GKELSKIPMPVNFNEPLSMLQRL 450
           EQ + +L E  +  +     + N SL +W+++K    G +LS++ +P    EP S L +L
Sbjct: 345 EQVQEELGELGEASQVETVSEENKSL-MWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKL 403

Query: 451 TEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFE---LDR 507
           ++   + +LL RAA  E++  ++  V  + +S +        KP+NP+LGETF       
Sbjct: 404 SDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHP 463

Query: 508 LEENGYRSLCEQVSHHPPAAAHHAES-KNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIF 566
             ++    + EQVSHHPP +A H  + K+G+ +   I   S+F G  LS +  G     F
Sbjct: 464 QTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTF 523

Query: 567 HATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVA-R 625
                 YT          I+ G + ++  G++ I   K   +  L+F    +F    +  
Sbjct: 524 LNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSIN 583

Query: 626 KVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNP 685
           +++G++T    +V  +L G WD  +       +  E  G +      + E R    +++ 
Sbjct: 584 QISGKITS-GEEVLASLSGHWDRDVF------IKEEGSGSSALFWTPSGEVRRQRLRQHT 636

Query: 686 LPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRL 745
           +P   +       L      W+  T           R +  G    A  EK  LEE QR 
Sbjct: 637 VPLEEQTELESERL------WQHVT-----------RAISKGDQHRATQEKFALEEAQRQ 679

Query: 746 SRKKREAEAMKATEDGTPYDPYKALWFERKKD 777
             ++R+   M         DP    W  R +D
Sbjct: 680 RARERQESLMPWKPQLFHLDPITQEWHYRYED 711


>gi|221136766 oxysterol-binding protein-like protein 5 isoform b
           [Homo sapiens]
          Length = 811

 Score =  102 bits (255), Expect = 1e-21
 Identities = 97/392 (24%), Positives = 166/392 (42%), Gaps = 31/392 (7%)

Query: 392 EQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCI-GKELSKIPMPVNFNEPLSMLQRL 450
           EQ + +L E  +  +     + N SL +W+++K    G +LS++ +P    EP S L +L
Sbjct: 277 EQVQEELGELGEASQVETVSEENKSL-MWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKL 335

Query: 451 TEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFE---LDR 507
           ++   + +LL RAA  E++  ++  V  + +S +        KP+NP+LGETF       
Sbjct: 336 SDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHP 395

Query: 508 LEENGYRSLCEQVSHHPPAAAHHAES-KNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIF 566
             ++    + EQVSHHPP +A H  + K+G+ +   I   S+F G  LS +  G     F
Sbjct: 396 QTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTF 455

Query: 567 HATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVA-R 625
                 YT          I+ G + ++  G++ I   K   +  L+F    +F    +  
Sbjct: 456 LNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSIN 515

Query: 626 KVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNP 685
           +++G++T    +V  +L G WD  +       +  E  G +      + E R    +++ 
Sbjct: 516 QISGKITS-GEEVLASLSGHWDRDVF------IKEEGSGSSALFWTPSGEVRRQRLRQHT 568

Query: 686 LPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRL 745
           +P   +       L      W+  T           R +  G    A  EK  LEE QR 
Sbjct: 569 VPLEEQTELESERL------WQHVT-----------RAISKGDQHRATQEKFALEEAQRQ 611

Query: 746 SRKKREAEAMKATEDGTPYDPYKALWFERKKD 777
             ++R+   M         DP    W  R +D
Sbjct: 612 RARERQESLMPWKPQLFHLDPITQEWHYRYED 643


>gi|22035609 oxysterol-binding protein-like protein 5 isoform b
           [Homo sapiens]
          Length = 811

 Score =  102 bits (255), Expect = 1e-21
 Identities = 97/392 (24%), Positives = 166/392 (42%), Gaps = 31/392 (7%)

Query: 392 EQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCI-GKELSKIPMPVNFNEPLSMLQRL 450
           EQ + +L E  +  +     + N SL +W+++K    G +LS++ +P    EP S L +L
Sbjct: 277 EQVQEELGELGEASQVETVSEENKSL-MWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKL 335

Query: 451 TEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFE---LDR 507
           ++   + +LL RAA  E++  ++  V  + +S +        KP+NP+LGETF       
Sbjct: 336 SDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHP 395

Query: 508 LEENGYRSLCEQVSHHPPAAAHHAES-KNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIF 566
             ++    + EQVSHHPP +A H  + K+G+ +   I   S+F G  LS +  G     F
Sbjct: 396 QTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTF 455

Query: 567 HATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYFSRDVA-R 625
                 YT          I+ G + ++  G++ I   K   +  L+F    +F    +  
Sbjct: 456 LNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSIN 515

Query: 626 KVTGEVTDPSGKVHFALLGTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRNP 685
           +++G++T    +V  +L G WD  +       +  E  G +      + E R    +++ 
Sbjct: 516 QISGKITS-GEEVLASLSGHWDRDVF------IKEEGSGSSALFWTPSGEVRRQRLRQHT 568

Query: 686 LPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQRL 745
           +P   +       L      W+  T           R +  G    A  EK  LEE QR 
Sbjct: 569 VPLEEQTELESERL------WQHVT-----------RAISKGDQHRATQEKFALEEAQRQ 611

Query: 746 SRKKREAEAMKATEDGTPYDPYKALWFERKKD 777
             ++R+   M         DP    W  R +D
Sbjct: 612 RARERQESLMPWKPQLFHLDPITQEWHYRYED 643


>gi|51243032 oxysterol-binding protein-like protein 8 isoform b
           [Homo sapiens]
          Length = 847

 Score =  100 bits (248), Expect = 7e-21
 Identities = 103/393 (26%), Positives = 167/393 (42%), Gaps = 33/393 (8%)

Query: 392 EQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCI-GKELSKIPMPVNFNEPLSMLQRL 450
           EQ   +L E  +  +T    + N SL +W+++K    G +LSK+ +P    EP S L +L
Sbjct: 339 EQSHEELGEAGEASQTETVSEENKSL-IWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKL 397

Query: 451 TEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFE---LDR 507
           ++   + + L  AA  EN   +L  V  + +S +        KP+NP+LGETF    +  
Sbjct: 398 SDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHP 457

Query: 508 LEENGYRSLCEQVSHHPPAAAHHAES-KNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIF 566
              +    + EQVSHHPP +A +  + K+G+ L   I   SKF G  LS +  G     F
Sbjct: 458 RTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTF 517

Query: 567 HATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYF-SRDVAR 625
              G  Y           I+ G + ++  G ++I   KTG    L+F    +  S D   
Sbjct: 518 LNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVN 577

Query: 626 KVTGEVTDPSGKVHFALL-GTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRN 684
           +++G++    GK   A L G WD   E F                  +  ++  + W  N
Sbjct: 578 QISGKL--KLGKEVLATLEGHWDS--EVFITD---------------KKTDNSEVFW--N 616

Query: 685 PLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQR 744
           P P    ++  +  +  T+   E G   ++   +   R +      EA  EK  LEE QR
Sbjct: 617 PTP----DIKQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQR 672

Query: 745 LSRKKREAEAMKATEDGTPYDPYKALWFERKKD 777
            + + R+ +  + +      DP    W  +  D
Sbjct: 673 QAARDRKTKNEEWSCKLFELDPLTGEWHYKFAD 705


>gi|18079218 oxysterol-binding protein-like protein 8 isoform a
           [Homo sapiens]
          Length = 889

 Score =  100 bits (248), Expect = 7e-21
 Identities = 103/393 (26%), Positives = 167/393 (42%), Gaps = 33/393 (8%)

Query: 392 EQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCI-GKELSKIPMPVNFNEPLSMLQRL 450
           EQ   +L E  +  +T    + N SL +W+++K    G +LSK+ +P    EP S L +L
Sbjct: 381 EQSHEELGEAGEASQTETVSEENKSL-IWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKL 439

Query: 451 TEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRTSKPFNPLLGETFE---LDR 507
           ++   + + L  AA  EN   +L  V  + +S +        KP+NP+LGETF    +  
Sbjct: 440 SDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHP 499

Query: 508 LEENGYRSLCEQVSHHPPAAAHHAES-KNGWTLRQEIKITSKFRGKYLSIMPLGTIHCIF 566
              +    + EQVSHHPP +A +  + K+G+ L   I   SKF G  LS +  G     F
Sbjct: 500 RTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTF 559

Query: 567 HATGHHYTWKKVTTTVHNIIVGKLWIDQSGEIDIVNHKTGDKCNLKFVPYSYF-SRDVAR 625
              G  Y           I+ G + ++  G ++I   KTG    L+F    +  S D   
Sbjct: 560 LNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVN 619

Query: 626 KVTGEVTDPSGKVHFALL-GTWDEKMECFKVQPVIGENGGDARQRGHEAEESRVMLWKRN 684
           +++G++    GK   A L G WD   E F                  +  ++  + W  N
Sbjct: 620 QISGKL--KLGKEVLATLEGHWDS--EVFITD---------------KKTDNSEVFW--N 658

Query: 685 PLPKNAENMYYFSELALTLNAWESGTAPTDSRLRPDQRLMENGRWDEANAEKQRLEEKQR 744
           P P    ++  +  +  T+   E G   ++   +   R +      EA  EK  LEE QR
Sbjct: 659 PTP----DIKQWRLIRHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQR 714

Query: 745 LSRKKREAEAMKATEDGTPYDPYKALWFERKKD 777
            + + R+ +  + +      DP    W  +  D
Sbjct: 715 QAARDRKTKNEEWSCKLFELDPLTGEWHYKFAD 747


>gi|54792084 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 3 [Homo
           sapiens]
          Length = 300

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 60/199 (30%), Positives = 98/199 (49%), Gaps = 20/199 (10%)

Query: 92  EGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVE--DSCNF 149
           EG L+KWTNY+ G+Q RWFVL NG+LSYY S+ ++    +G+I +A   I V   D+   
Sbjct: 2   EGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRM 61

Query: 150 IISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQN 209
            +   G Q +++KA +  ERQRW+ AL  +KA       + ++             E+  
Sbjct: 62  ELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEK-------------EISE 108

Query: 210 TLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITS 269
           T  +L +K+ +L    DL+ +    +Q  +   E+   P+  N     +NE ++L   T 
Sbjct: 109 TSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAEN-----MNEASSLLSATC 163

Query: 270 NAMINACRDFLMLAQTHSK 288
           N  I    + + +A    K
Sbjct: 164 NTFITTLEECVKIANAKFK 182


>gi|14249174 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 8 [Homo
           sapiens]
          Length = 440

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 61/194 (31%), Positives = 95/194 (48%), Gaps = 24/194 (12%)

Query: 92  EGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVE--DSCNF 149
           EG L+KWTNY+ G+Q RWF+L  G+LSYY S  +    C+G+I +A   I V   D+   
Sbjct: 2   EGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRM 61

Query: 150 IISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQN 209
            +   G Q ++LKA S  ERQRW+ AL  AKA               +S +Q +K   +N
Sbjct: 62  DLIIPGEQYFYLKARSVAERQRWLVALGSAKACLT------------DSRTQKEKEFAEN 109

Query: 210 TLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITS 269
           T   L +K+ +L    DL       L + + + + +     SN   ++  +  TL + T 
Sbjct: 110 T-ENLKTKMSELRLYCDL-------LVQQVDKTKEVTTTGVSNS--EEGIDVGTLLKSTC 159

Query: 270 NAMINACRDFLMLA 283
           N  +    + + +A
Sbjct: 160 NTFLKTLEECMQIA 173


>gi|194294543 alpha 3 type IV collagen binding protein isoform 3
           [Homo sapiens]
          Length = 752

 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 70/209 (33%), Positives = 101/209 (48%), Gaps = 22/209 (10%)

Query: 42  GSGAASGTVVAAAAGGPGPGAGGVAAAGPAPAPPTGGSGGSGAGGSGSARE--GWLFKWT 99
           G GA+SG   AA   G G   G  A+     +  + GS       SG   E  G L KWT
Sbjct: 106 GLGASSG---AAEGAGAGLLLGCRASMSDNQSWNSSGSEEDPETESGPPVERCGVLSKWT 162

Query: 100 NYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVE--DSCNFIISNGGAQ 157
           NYI G+Q RW VL N  LSYY+S+ E  + CRG+I L+ A IT    D C F IS   + 
Sbjct: 163 NYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFDISVNDS- 221

Query: 158 TYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQNTLRTLSSK 217
            ++L+A     RQ+W+ A+E  K ++          G E S+ +        ++ +L S 
Sbjct: 222 VWYLRAQDPDHRQQWIDAIEQHKTES--------GYGSESSLRR------HGSMVSLVSG 267

Query: 218 VEDLSTCNDLIAKHGTALQRSLSELESLK 246
               S  +    K G +L+  L+E+E+ +
Sbjct: 268 ASGYSATSTSSFKKGHSLREKLAEMETFR 296


>gi|14165452 alpha 3 type IV collagen binding protein isoform 2
           [Homo sapiens]
          Length = 598

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 55/158 (34%), Positives = 82/158 (51%), Gaps = 17/158 (10%)

Query: 91  REGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVE--DSCN 148
           R G L KWTNYI G+Q RW VL N  LSYY+S+ E  + CRG+I L+ A IT    D C 
Sbjct: 26  RCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECR 85

Query: 149 FIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQ 208
           F IS   +  ++L+A     RQ+W+ A+E  K ++          G E S+ +       
Sbjct: 86  FDISVNDS-VWYLRAQDPDHRQQWIDAIEQHKTES--------GYGSESSLRR------H 130

Query: 209 NTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLK 246
            ++ +L S     S  +    K G +L+  L+E+E+ +
Sbjct: 131 GSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFR 168


>gi|5031717 alpha 3 type IV collagen binding protein isoform 1 [Homo
           sapiens]
          Length = 624

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 55/158 (34%), Positives = 82/158 (51%), Gaps = 17/158 (10%)

Query: 91  REGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVE--DSCN 148
           R G L KWTNYI G+Q RW VL N  LSYY+S+ E  + CRG+I L+ A IT    D C 
Sbjct: 26  RCGVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECR 85

Query: 149 FIISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQ 208
           F IS   +  ++L+A     RQ+W+ A+E  K ++          G E S+ +       
Sbjct: 86  FDISVNDS-VWYLRAQDPDHRQQWIDAIEQHKTES--------GYGSESSLRR------H 130

Query: 209 NTLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLK 246
            ++ +L S     S  +    K G +L+  L+E+E+ +
Sbjct: 131 GSMVSLVSGASGYSATSTSSFKKGHSLREKLAEMETFR 168


>gi|22547171 oxysterol binding protein-like 9 isoform c [Homo
           sapiens]
          Length = 626

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 90/414 (21%), Positives = 169/414 (40%), Gaps = 67/414 (16%)

Query: 379 SNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPV 438
           S++S  +SD  L + +  + ++ +         + + S+ +  + +  +G +L+K+ +P 
Sbjct: 231 SSLSNGTSDADLFDSHDDRDDDAEAGS-----VEEHKSVIMHLLSQVRLGMDLTKVVLPT 285

Query: 439 NFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRT--SKPFN 496
              E  S+L+   +   + +L    +  ++  +++  V  + +S++      +   KP+N
Sbjct: 286 FILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYN 345

Query: 497 PLLGETFE--------------------LDRLEENGYRSLCEQVSHHPPAAAHHAESKN- 535
           P+LGE F+                    +  + +N    + EQVSHHPP +A +AE  N 
Sbjct: 346 PILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNK 405

Query: 536 GWTLRQEIKITSKFRGKYLSIMPL--GTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWID 593
                  I   SKF G  + +  +  G + C+ +    HY          +I+    W++
Sbjct: 406 KIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY--DEHYILTFPNGYGRSILTVP-WVE 462

Query: 594 QSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHF-ALLGTWDEKMEC 652
             GE +I   KTG   N+ F    ++      ++T E+  P+ K  F ++ G W+  M  
Sbjct: 463 LGGECNINCSKTGYSANIIFHTKPFYG-GKKHRITAEIFSPNDKKSFCSIEGEWNGVM-- 519

Query: 653 FKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAP 712
              +   GEN           +  ++ + K+       +N Y    L      W+  T  
Sbjct: 520 -YAKYATGEN-------TVFVDTKKLPIIKKKVRKLEDQNEYESRSL------WKDVTFN 565

Query: 713 TDSRLRPDQRLMENGRWDEANAEKQRLEEKQRL-SRKKREAEAMKAT----EDG 761
              R             D A   K RLEE+QR  +R+++E E    T    EDG
Sbjct: 566 LKIR-----------DIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDG 608


>gi|22547169 oxysterol binding protein-like 9 isoform b [Homo
           sapiens]
          Length = 571

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 90/414 (21%), Positives = 169/414 (40%), Gaps = 67/414 (16%)

Query: 379 SNISGASSDISLDEQYKHQLEETKKEKRTRIPYKPNYSLNLWSIMKNCIGKELSKIPMPV 438
           S++S  +SD  L + +  + ++ +         + + S+ +  + +  +G +L+K+ +P 
Sbjct: 176 SSLSNGTSDADLFDSHDDRDDDAEAGS-----VEEHKSVIMHLLSQVRLGMDLTKVVLPT 230

Query: 439 NFNEPLSMLQRLTEDLEYHELLDRAAKCENSLEQLCYVAAFTVSSYSTTVFRT--SKPFN 496
              E  S+L+   +   + +L    +  ++  +++  V  + +S++      +   KP+N
Sbjct: 231 FILERRSLLEMYADFFAHPDLFVSISDQKDPKDRMVQVVKWYLSAFHAGRKGSVAKKPYN 290

Query: 497 PLLGETFE--------------------LDRLEENGYRSLCEQVSHHPPAAAHHAESKN- 535
           P+LGE F+                    +  + +N    + EQVSHHPP +A +AE  N 
Sbjct: 291 PILGEIFQCHWTLPNDTEENTELVSEGPVPWVSKNSVTFVAEQVSHHPPISAFYAECFNK 350

Query: 536 GWTLRQEIKITSKFRGKYLSIMPL--GTIHCIFHATGHHYTWKKVTTTVHNIIVGKLWID 593
                  I   SKF G  + +  +  G + C+ +    HY          +I+    W++
Sbjct: 351 KIQFNAHIWTKSKFLGMSIGVHNIGQGCVSCLDY--DEHYILTFPNGYGRSILTVP-WVE 407

Query: 594 QSGEIDIVNHKTGDKCNLKFVPYSYFSRDVARKVTGEVTDPSGKVHF-ALLGTWDEKMEC 652
             GE +I   KTG   N+ F    ++      ++T E+  P+ K  F ++ G W+  M  
Sbjct: 408 LGGECNINCSKTGYSANIIFHTKPFYG-GKKHRITAEIFSPNDKKSFCSIEGEWNGVM-- 464

Query: 653 FKVQPVIGENGGDARQRGHEAEESRVMLWKRNPLPKNAENMYYFSELALTLNAWESGTAP 712
              +   GEN           +  ++ + K+       +N Y    L      W+  T  
Sbjct: 465 -YAKYATGEN-------TVFVDTKKLPIIKKKVRKLEDQNEYESRSL------WKDVTFN 510

Query: 713 TDSRLRPDQRLMENGRWDEANAEKQRLEEKQRL-SRKKREAEAMKAT----EDG 761
              R             D A   K RLEE+QR  +R+++E E    T    EDG
Sbjct: 511 LKIR-----------DIDAATEAKHRLEERQRAEARERKEKEIQWETRLFHEDG 553


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,471,711
Number of Sequences: 37866
Number of extensions: 1858513
Number of successful extensions: 29658
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 494
Number of HSP's successfully gapped in prelim test: 810
Number of HSP's that attempted gapping in prelim test: 13487
Number of HSP's gapped (non-prelim): 9135
length of query: 807
length of database: 18,247,518
effective HSP length: 110
effective length of query: 697
effective length of database: 14,082,258
effective search space: 9815333826
effective search space used: 9815333826
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.