Search of human proteins with 4504901

Search of human proteins with 4504901

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504901 karyopherin alpha 4 [Homo sapiens]
         (521 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504901 karyopherin alpha 4 [Homo sapiens]                        1039   0.0  
gi|34485722 karyopherin alpha 3 [Homo sapiens]                        905   0.0  
gi|4504897 karyopherin alpha 2 [Homo sapiens]                         514   e-146
gi|6912478 karyopherin alpha 6 [Homo sapiens]                         479   e-135
gi|39812229 karyopherin alpha 5 [Homo sapiens]                        476   e-134
gi|222144293 karyopherin alpha 1 [Homo sapiens]                       462   e-130
gi|224589129 karyopherin 7 [Homo sapiens]                             428   e-120
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]         77   3e-14
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]        77   3e-14
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]     52   2e-06
gi|189409124 armadillo repeat containing 3 [Homo sapiens]              48   2e-05
gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens]     45   2e-04
gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens]     45   2e-04
gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]     45   2e-04
gi|53829376 plakophilin 4 isoform b [Homo sapiens]                     40   0.004
gi|53829374 plakophilin 4 isoform a [Homo sapiens]                     40   0.004
gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]      40   0.005
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD...    39   0.009
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD...    39   0.009
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ...    39   0.009
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]     39   0.012
gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) iso...    38   0.026
gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) iso...    38   0.026
gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isof...    38   0.026
gi|4502247 armadillo repeat protein [Homo sapiens]                     38   0.026
gi|28875784 armadillo repeat containing 5 isoform b [Homo sapiens]     38   0.026
gi|157426856 armadillo repeat containing 5 isoform a [Homo sapiens]    38   0.026
gi|154090976 sterile alpha and TIR motif containing 1 [Homo sapi...    37   0.034
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [...    37   0.044
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [...    37   0.044

>gi|4504901 karyopherin alpha 4 [Homo sapiens]
          Length = 521

 Score = 1039 bits (2687), Expect = 0.0
 Identities = 521/521 (100%), Positives = 521/521 (100%)

Query: 1   MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDS 60
           MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDS
Sbjct: 1   MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDS 60

Query: 61  DIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV 120
           DIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV
Sbjct: 61  DIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV 120

Query: 121 HCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWA 180
           HCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWA
Sbjct: 121 HCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWA 180

Query: 181 LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETI 240
           LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETI
Sbjct: 181 LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETI 240

Query: 241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKV 300
           QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKV
Sbjct: 241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKV 300

Query: 301 QTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQ 360
           QTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQ
Sbjct: 301 QTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQ 360

Query: 361 VQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLL 420
           VQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLL
Sbjct: 361 VQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLL 420

Query: 421 TVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEI 480
           TVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEI
Sbjct: 421 TVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEI 480

Query: 481 IDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF 521
           IDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF
Sbjct: 481 IDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF 521


>gi|34485722 karyopherin alpha 3 [Homo sapiens]
          Length = 521

 Score =  905 bits (2338), Expect = 0.0
 Identities = 447/521 (85%), Positives = 481/521 (92%)

Query: 1   MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDS 60
           MA+N  L+N R+K+FKNKGRD+ETMRR RNEV VELRKNKRDEHLLK+RNVP E+  EDS
Sbjct: 1   MAENPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDS 60

Query: 61  DIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV 120
           D+D D++ QN +LEAI+QNA+SDN  +QLSAVQAARKLLSSDRNPPIDDLIKSGILPILV
Sbjct: 61  DVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILV 120

Query: 121 HCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWA 180
            CLERDDNPSLQFEAAWALTNIASGTS QTQAVVQSNAVPLFLRLL SPHQNVCEQAVWA
Sbjct: 121 KCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWA 180

Query: 181 LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETI 240
           LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWV+VNLCR+KDPPPPMET+
Sbjct: 181 LGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETV 240

Query: 241 QEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKV 300
           QEILPALCVLI+HTD+NILVDTVWALSYLTD GNEQIQMVIDSG+VP LVPLLSHQEVKV
Sbjct: 241 QEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKV 300

Query: 301 QTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQ 360
           QTAALRAVGNIVTGTDEQTQVVLNCD LSHFP LL+HPKEKINKEAVWFLSNITAGNQQQ
Sbjct: 301 QTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQ 360

Query: 361 VQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLL 420
           VQAVIDA L+PMIIH L KGDFGTQKEAAWAISNLTISGRKDQV YL+QQNVIPPFCNLL
Sbjct: 361 VQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLL 420

Query: 421 TVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEI 480
           +VKD+QVVQVVLDGL NIL MA DEA TI  +IEECGGLEKIE LQ HENEDIYKLA+EI
Sbjct: 421 SVKDSQVVQVVLDGLKNILIMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEI 480

Query: 481 IDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF 521
           IDQ+FS DDIDEDP L+PEA QGGT+ F+ +AN+ T+ F F
Sbjct: 481 IDQYFSGDDIDEDPCLIPEATQGGTYNFDPTANLQTKEFNF 521


>gi|4504897 karyopherin alpha 2 [Homo sapiens]
          Length = 529

 Score =  514 bits (1323), Expect = e-146
 Identities = 265/520 (50%), Positives = 356/520 (68%), Gaps = 11/520 (2%)

Query: 3   DNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNV---PHEDICED 59
           +N      RL  FKNKG+D   MRR+R EV VELRK K+D+ +LKRRNV   P +     
Sbjct: 5   ENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPL 64

Query: 60  SDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPIL 119
            +   +    N S++ IV+  +S N   QL A QAARKLLS ++ PPID++I++G++P  
Sbjct: 65  QENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKF 124

Query: 120 VHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVW 179
           V  L R D   +QFE+AWALTNIASGTSEQT+AVV   A+P F+ LL SPH ++ EQAVW
Sbjct: 125 VSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVW 184

Query: 180 ALGNIIGDGPQCRDYVISLGVVKPLLSFIS----PSIPITFLRNVTWVMVNLCRHKDPPP 235
           ALGNI GDG   RD VI  G V PLL+ ++     S+   +LRN+TW + NLCR+K+P P
Sbjct: 185 ALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAP 244

Query: 236 PMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSH 295
           P++ +++ILP L  L+HH D  +L DT WA+SYLTD  NE+I MV+ +G+VP LV LL  
Sbjct: 245 PIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGA 304

Query: 296 QEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITA 355
            E+ + T ALRA+GNIVTGTDEQTQVV++  AL+ FP+LLT+PK  I KEA W +SNITA
Sbjct: 305 SELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 364

Query: 356 GNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 415
           G Q Q+Q V++  LVP ++ +L K DF TQKEA WA++N T  G  +Q+ YL+   +I P
Sbjct: 365 GRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEP 424

Query: 416 FCNLLTVKDAQVVQVVLDGLSNILKMAE--DEAETIGNLIEECGGLEKIEQLQNHENEDI 473
             NLLT KD +++ V+LD +SNI + AE   E E +  +IEECGGL+KIE LQNHENE +
Sbjct: 425 LMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESV 484

Query: 474 YKLAYEIIDQFFSSDDIDEDPSLVPEAI-QGGTFGFNSSA 512
           YK +  +I+++FS ++ +ED ++VPE   +G TF     A
Sbjct: 485 YKASLSLIEKYFSVEE-EEDQNVVPETTSEGYTFQVQDGA 523


>gi|6912478 karyopherin alpha 6 [Homo sapiens]
          Length = 536

 Score =  479 bits (1233), Expect = e-135
 Identities = 253/528 (47%), Positives = 352/528 (66%), Gaps = 17/528 (3%)

Query: 8   DNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVP--HEDICEDSDIDGD 65
           DN R+K++KN   + E MRR+R E  ++LRK KR++ L KRRNV   +E+      +  D
Sbjct: 10  DNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMD 69

Query: 66  YRVQNTSLEAI-----VQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSG-ILPIL 119
             V +T+ E++     V+   SD+  +QL+  Q  RKLLS + +PPID++I +  ++   
Sbjct: 70  SYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRF 129

Query: 120 VHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVW 179
           V  L+R++N +LQFEAAWALTNIASGTS+QT+ V+++ AVP+F+ LL+S  ++V EQAVW
Sbjct: 130 VEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQEQAVW 189

Query: 180 ALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMET 239
           ALGNI GD   CRDYV++  ++ PLL+ ++ S  +T  RN  W + NLCR K+PPP    
Sbjct: 190 ALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAK 249

Query: 240 IQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVK 299
           +   LP L  L+  +D ++L D  WALSYL+D  NE+IQ VIDSG+   LV LL H + K
Sbjct: 250 VSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYK 309

Query: 300 VQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQ 359
           V + ALRAVGNIVTG D QTQV+LNC AL     LL+ PKE I KEA W +SNITAGN+ 
Sbjct: 310 VASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRA 369

Query: 360 QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNL 419
           Q+QAVIDAN+ P++I +L K +F T+KEAAWAI+N T  G  +Q+ YL+    I P C+L
Sbjct: 370 QIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDL 429

Query: 420 LTVKDAQVVQVVLDGLSNILKMAEDEAETIGN-------LIEECGGLEKIEQLQNHENED 472
           LTV D+++VQV L+GL NIL++ E E +  G+       LIEE  GL+KIE LQ+HEN++
Sbjct: 430 LTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQE 489

Query: 473 IYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQ 520
           IY+ A+++I+ +F  +  D+D SL P+  +            P EGFQ
Sbjct: 490 IYQKAFDLIEHYFGVE--DDDSSLAPQVDETQQQFIFQQPEAPMEGFQ 535


>gi|39812229 karyopherin alpha 5 [Homo sapiens]
          Length = 539

 Score =  476 bits (1226), Expect = e-134
 Identities = 255/531 (48%), Positives = 350/531 (65%), Gaps = 20/531 (3%)

Query: 8   DNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNV--PHEDIC------ED 59
           DN R+K++KNK  + + MRR+R E  ++LRK KR+E L KRRNV  P  D        +D
Sbjct: 10  DNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQD 69

Query: 60  SDIDGDYRVQNTSLEA--IVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLI-KSGIL 116
            DI     +    +    +VQ   S+N   QL+A Q  RKLLS + NPPID +I K G++
Sbjct: 70  PDISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVV 129

Query: 117 PILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQ 176
              V  LER++N +LQFEAAWALTNIASGT   T+ V+++ AVP+F++LL+S H++V EQ
Sbjct: 130 QRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQ 189

Query: 177 AVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPP 236
           AVWALGNI GD  +CRD+V++  ++ PLL  ++ S  +T  RN  W + NLCR K+PPP 
Sbjct: 190 AVWALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPN 249

Query: 237 METIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQ 296
              +   L  L  L+  +D ++L D  WALSYL+D  N++IQ VIDSG+   LV LL H 
Sbjct: 250 FSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLMHN 309

Query: 297 EVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAG 356
           + KV + ALRAVGNIVTG D QTQV+LNC AL     LL+ PKE I KEA W +SNITAG
Sbjct: 310 DYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNITAG 369

Query: 357 NQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPF 416
           N+ Q+QAVIDAN+ P++I +L K +F T+KEAAWAI+N T  G  +Q+ YL+    I P 
Sbjct: 370 NRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIKPL 429

Query: 417 CNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIG-------NLIEECGGLEKIEQLQNHE 469
           C+LLTV D+++VQV L+GL NIL++ E E++  G        LIEE  GL+KIE LQ+HE
Sbjct: 430 CDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQSHE 489

Query: 470 NEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQ 520
           N++IY+ A+++I+ +F  +  ++DPS+VP+  +            P +GFQ
Sbjct: 490 NQEIYQKAFDLIEHYFGVE--EDDPSIVPQVDENQQQFIFQQQEAPMDGFQ 538


>gi|222144293 karyopherin alpha 1 [Homo sapiens]
          Length = 538

 Score =  462 bits (1190), Expect = e-130
 Identities = 251/533 (47%), Positives = 341/533 (63%), Gaps = 22/533 (4%)

Query: 8   DNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVP--HEDICEDSDIDGD 65
           +N RLK++KNK  + + MRR+R E  ++LRK KR+E L KRRNV    E+  E+   DG 
Sbjct: 7   ENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGG 66

Query: 66  YR-VQNTSLEA---------IVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKS-G 114
           +   Q +++E          +++   S +   QLSA Q  RKLLS + NPPID++I + G
Sbjct: 67  FHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPG 126

Query: 115 ILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVC 174
           ++   V  L+R +N +LQFE+AW LTNIASG S QT+ V+Q+ AVP+F+ LL S  ++V 
Sbjct: 127 VVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQ 186

Query: 175 EQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPP 234
           EQAVWALGNI GD   CRDYV+   ++ PLL   S    +T  RN  W + NLCR K PP
Sbjct: 187 EQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPP 246

Query: 235 PPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLS 294
           P    +   L  L  L+  +D ++L D  WALSYL+D  N++IQ VID+G+   LV LL 
Sbjct: 247 PEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLM 306

Query: 295 HQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNIT 354
           H + KV + ALRAVGNIVTG D QTQV+LNC AL     LL+ PKE I KEA W +SNIT
Sbjct: 307 HNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNIT 366

Query: 355 AGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIP 414
           AGN+ Q+Q VIDAN+ P +I +L   +F T+KEAAWAI+N T  G  +Q+ YL++   I 
Sbjct: 367 AGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIK 426

Query: 415 PFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGN-------LIEECGGLEKIEQLQN 467
           P C+LLTV D+++VQV L+GL NIL++ E EA+  G        LIEE  GL+KIE LQ+
Sbjct: 427 PLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQS 486

Query: 468 HENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQ 520
           HEN++IY+ A+++I+ +F ++  DED S+ P+               P EGFQ
Sbjct: 487 HENQEIYQKAFDLIEHYFGTE--DEDSSIAPQVDLNQQQYIFQQCEAPMEGFQ 537


>gi|224589129 karyopherin 7 [Homo sapiens]
          Length = 516

 Score =  428 bits (1100), Expect = e-120
 Identities = 224/496 (45%), Positives = 322/496 (64%), Gaps = 7/496 (1%)

Query: 10  QRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYR-- 67
           +R + FK +G+D+   R+QR  V +ELRK K+DE  LKRRN+     C D+  +   +  
Sbjct: 9   ERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNIT--SFCPDTPSEKTAKGV 66

Query: 68  VQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDD 127
             + +L  I++  +S +  +   A Q ARK+LS ++NPP+  +I++G++P +V  L+   
Sbjct: 67  AVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSL 126

Query: 128 NPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGD 187
            P LQFEAAWALTNIASGTSEQT+AVV+  A+   + LL S +  VCEQAVWALGNI GD
Sbjct: 127 YPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGD 186

Query: 188 GPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPAL 247
           GP+ RD VI+   +  LL+ ISP++PITFLRN+TW + NLCR+K+P P    +++ILPAL
Sbjct: 187 GPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPAL 246

Query: 248 CVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRA 307
             L+ H D  +L D  WALSYLTD  N++I  V+++G++P LV L++  E+ V T +LR 
Sbjct: 247 LHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRT 306

Query: 308 VGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDA 367
           VGNIVTGTDEQTQ+ ++   L+  P LL H K  I KEA W LSN+ AG    +Q ++  
Sbjct: 307 VGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAY 366

Query: 368 NLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQV 427
           +++P ++ LL  G+F  QKEA W ++N       DQ+  L+   V+ P  NLLT  D ++
Sbjct: 367 DVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKI 426

Query: 428 VQVVLDGLSNILKMAE--DEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFF 485
           V ++LD +S IL+ AE   E E +  LIEE GG+++IE LQ HEN  I + A  II++ F
Sbjct: 427 VLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQSALNIIEKHF 486

Query: 486 SSDDIDEDPSLVPEAI 501
             ++ DE  +L+ + I
Sbjct: 487 GEEE-DESQTLLSQVI 501


>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
          Length = 509

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 62/269 (23%), Positives = 113/269 (42%), Gaps = 5/269 (1%)

Query: 110 LIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSP 169
           ++  G L  LV CLE D +P ++  AAWAL  IA   +E +QAVV + AVPL +  +  P
Sbjct: 121 IVDCGALDTLVICLE-DFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179

Query: 170 HQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVMVNLC 228
              +   A  AL +I    P+    V+  G V  L   I +P   +     +   +  + 
Sbjct: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237

Query: 229 RHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPH 288
           +H      M    EI P +   +   D  +  +    +  +     E  Q+V+++G V  
Sbjct: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297

Query: 289 LVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLT-HPKEKINKEAV 347
           ++  +   +   +   +  +G +   ++     V+    +      L+  P++ I   A 
Sbjct: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357

Query: 348 WFLSNITAGNQQQVQAVIDANLVPMIIHL 376
           W L  I     +  +AV   N +P+++ L
Sbjct: 358 WALGQIGRHTPEHARAVAVTNTLPVLLSL 386



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 46/304 (15%)

Query: 92  VQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQ 151
           VQ   +L +  +N  I+ L  +G++ +L   L  D  P++Q  AA AL  +A+   +  +
Sbjct: 21  VQMVAELATRPQN--IETLQNAGVMSLL-RTLLLDVVPTIQQTAALALGRLANYNDDLAE 77

Query: 152 AVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS 211
           AVV+ + +P  +  L   ++   + A + L  +    PQ    ++  G            
Sbjct: 78  AVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGA----------- 126

Query: 212 IPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD 271
                                           L  L + +   D  +     WAL Y+  
Sbjct: 127 --------------------------------LDTLVICLEDFDPGVKEAAAWALRYIAR 154

Query: 272 AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHF 331
              E  Q V+D+G VP LV  +   E+ ++  A  A+ +I   + E  Q V++  A++H 
Sbjct: 155 HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHL 214

Query: 332 PALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWA 391
             ++ +P  K+  + +  LS ++  +    + V++A + P+++  L   D   +K A+  
Sbjct: 215 AQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTL 274

Query: 392 ISNL 395
           I  +
Sbjct: 275 IREI 278



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 2/137 (1%)

Query: 32  VVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSA 91
           VV+   K+K DE++ K  +    +I + +       V    + A++    S     +L  
Sbjct: 255 VVLTCLKDK-DEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPG 313

Query: 92  VQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQ 151
           +     + +   N  +  +I  G+ P L  CL  +    ++  AAWAL  I   T E  +
Sbjct: 314 IMMLGYVAAHSENLAMAVIISKGV-PQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHAR 372

Query: 152 AVVQSNAVPLFLRLLHS 168
           AV  +N +P+ L L  S
Sbjct: 373 AVAVTNTLPVLLSLYMS 389


>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
          Length = 458

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 62/269 (23%), Positives = 113/269 (42%), Gaps = 5/269 (1%)

Query: 110 LIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSP 169
           ++  G L  LV CLE D +P ++  AAWAL  IA   +E +QAVV + AVPL +  +  P
Sbjct: 121 IVDCGALDTLVICLE-DFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEP 179

Query: 170 HQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVMVNLC 228
              +   A  AL +I    P+    V+  G V  L   I +P   +     +   +  + 
Sbjct: 180 EIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLK--HQILSALSQVS 237

Query: 229 RHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPH 288
           +H      M    EI P +   +   D  +  +    +  +     E  Q+V+++G V  
Sbjct: 238 KHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAA 297

Query: 289 LVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLT-HPKEKINKEAV 347
           ++  +   +   +   +  +G +   ++     V+    +      L+  P++ I   A 
Sbjct: 298 VIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAA 357

Query: 348 WFLSNITAGNQQQVQAVIDANLVPMIIHL 376
           W L  I     +  +AV   N +P+++ L
Sbjct: 358 WALGQIGRHTPEHARAVAVTNTLPVLLSL 386



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 46/304 (15%)

Query: 92  VQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQ 151
           VQ   +L +  +N  I+ L  +G++ +L   L  D  P++Q  AA AL  +A+   +  +
Sbjct: 21  VQMVAELATRPQN--IETLQNAGVMSLL-RTLLLDVVPTIQQTAALALGRLANYNDDLAE 77

Query: 152 AVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPS 211
           AVV+ + +P  +  L   ++   + A + L  +    PQ    ++  G            
Sbjct: 78  AVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGA----------- 126

Query: 212 IPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTD 271
                                           L  L + +   D  +     WAL Y+  
Sbjct: 127 --------------------------------LDTLVICLEDFDPGVKEAAAWALRYIAR 154

Query: 272 AGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHF 331
              E  Q V+D+G VP LV  +   E+ ++  A  A+ +I   + E  Q V++  A++H 
Sbjct: 155 HNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHL 214

Query: 332 PALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWA 391
             ++ +P  K+  + +  LS ++  +    + V++A + P+++  L   D   +K A+  
Sbjct: 215 AQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTL 274

Query: 392 ISNL 395
           I  +
Sbjct: 275 IREI 278



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 34/137 (24%), Positives = 59/137 (43%), Gaps = 2/137 (1%)

Query: 32  VVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSA 91
           VV+   K+K DE++ K  +    +I + +       V    + A++    S     +L  
Sbjct: 255 VVLTCLKDK-DEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPG 313

Query: 92  VQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQ 151
           +     + +   N  +  +I  G+ P L  CL  +    ++  AAWAL  I   T E  +
Sbjct: 314 IMMLGYVAAHSENLAMAVIISKGV-PQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHAR 372

Query: 152 AVVQSNAVPLFLRLLHS 168
           AV  +N +P+ L L  S
Sbjct: 373 AVAVTNTLPVLLSLYMS 389


>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
          Length = 493

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 102/488 (20%), Positives = 187/488 (38%), Gaps = 65/488 (13%)

Query: 22  LETMRRQRNEVVVELRKNKRDEHLLKR---RNVPHEDICED--SDIDGDYRVQNTSLEAI 76
           +E +RR+R E    LRK +R++ L+ +   RN   E+  E   + I G+  VQ    +A 
Sbjct: 16  VEELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQ 75

Query: 77  VQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAA 136
                 + +G   + V   R L   +       L   G +  LV  L   +   LQ EAA
Sbjct: 76  RGTEEKEREG---ALVSLRRGLQHPETQQTFIRL--EGSMRTLVGLL-TSNQALLQLEAA 129

Query: 137 WALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVI 196
             L  + S + + T A     A    L  L S   +  E  ++ LGN+I +    R  ++
Sbjct: 130 RCLHEL-SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLL 188

Query: 197 SLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPP-----------PMETIQEILP 245
             G+V P L+    S  +  L  + + +  L + ++ P            P   +Q + P
Sbjct: 189 PQGIV-PALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPSILASTLPQHMLQMLQP 247

Query: 246 ALCVLIHHTDVNILVDTVWALSYL--TDAGNE--------------------QIQMVIDS 283
                    +  + V+  W L Y+  +   N                      +Q   D+
Sbjct: 248 G-----PKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQKTEDA 302

Query: 284 GIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKIN 343
           G+     P+L      +  AA+  VG  +   DE+        AL          +  + 
Sbjct: 303 GLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVA-----ALFILLQFFFQKQPSLL 357

Query: 344 KEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQ 403
            E +W L+N+TA +     +++  +L+  ++ LL   +          + N+   G    
Sbjct: 358 PEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNV-VSVMVLTVLCNVAEKG-PAY 415

Query: 404 VAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIE 463
              L    ++P   + L   D +VV   L+ L ++L + + EA  +   +++ G    ++
Sbjct: 416 CQRLWPGPLLPALLHTLAFSDTEVVGQSLE-LLHLLFLYQPEAVQV--FLQQSG----LQ 468

Query: 464 QLQNHENE 471
            L+ H+ E
Sbjct: 469 ALERHQEE 476


>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
          Length = 872

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 76/384 (19%), Positives = 141/384 (36%), Gaps = 53/384 (13%)

Query: 135 AAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 194
           A+  L N+++  + + Q        PL +RLL SP  +V + ++  + N++ D  QCR  
Sbjct: 129 ASLCLANMSAEYTSKVQIFEHGGLEPL-IRLLSSPDPDVKKNSMECIYNLVQDF-QCRAK 186

Query: 195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQ------------- 241
           +  L  + P+L  +    P+  L  +  + V +   K+    +   Q             
Sbjct: 187 LQELNAIPPILDLLKSEYPVIQLLALKTLGV-IANDKESRTMLRDNQGLDHLIKILETKE 245

Query: 242 ------EILPALCVLIHHTDVNILVDTVWAL---------SYLTDAGNEQIQMVIDSGIV 286
                 E L  +   +   D  + +     L         S + D      + +  +   
Sbjct: 246 LNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKAAYD 305

Query: 287 PHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCD-----------ALSHFPALL 335
           P    L   QEV+    AL    N  T       +   C+            +     LL
Sbjct: 306 PENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNNQGIPQLIQLL 365

Query: 336 THPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNL 395
               E++ + A   L+N+T  N     A  +A+ +  +I+LL     G    AA  ++N+
Sbjct: 366 KSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIANAATVLTNM 425

Query: 396 TISG--RKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLI 453
            +    R +   + I   +I P  +  TV  ++    V     ++      EA T    +
Sbjct: 426 AMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACDV------EART---EL 476

Query: 454 EECGGLEKIEQLQNHENEDIYKLA 477
              GGLE + +L   +N+++ K A
Sbjct: 477 RNSGGLEPLVELLRSKNDEVRKHA 500



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 60/256 (23%), Positives = 113/256 (44%), Gaps = 17/256 (6%)

Query: 234 PPPMETIQEIL------PALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVP 287
           PPP +    ++        + ++++  +  IL     A+      G E    +++ G V 
Sbjct: 11  PPPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVE 70

Query: 288 HLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKE-A 346
            L  LL+H++  V+  A    G I+   ++  +++   D ++   A L   +E +  E A
Sbjct: 71  PLTKLLTHEDKIVRRNATMIFG-ILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFA 129

Query: 347 VWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAY 406
              L+N++A    +VQ      L P +I LL   D   +K +   I NL    +    A 
Sbjct: 130 SLCLANMSAEYTSKVQIFEHGGLEP-LIRLLSSPDPDVKKNSMECIYNLVQDFQCR--AK 186

Query: 407 LIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEK-IEQL 465
           L + N IPP  +LL   +  V+Q++   L  +  +A D+      ++ +  GL+  I+ L
Sbjct: 187 LQELNAIPPILDLLK-SEYPVIQLL--ALKTLGVIANDKESR--TMLRDNQGLDHLIKIL 241

Query: 466 QNHENEDIYKLAYEII 481
           +  E  D++  A  +I
Sbjct: 242 ETKELNDLHIEALAVI 257



 Score = 38.1 bits (87), Expect = 0.020
 Identities = 32/160 (20%), Positives = 70/160 (43%), Gaps = 2/160 (1%)

Query: 153 VVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSI 212
           +++S      + +L+SP + +  +A  A+      G + +  ++ LG V+PL   ++   
Sbjct: 21  MIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHED 80

Query: 213 PITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDA 272
            I   RN T +   L  + D    +  +  +   +  L    +V I       L+ ++  
Sbjct: 81  KIV-RRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAE 139

Query: 273 GNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIV 312
              ++Q+    G+ P L+ LLS  +  V+  ++  + N+V
Sbjct: 140 YTSKVQIFEHGGLEP-LIRLLSSPDPDVKKNSMECIYNLV 178


>gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens]
          Length = 385

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 67/311 (21%), Positives = 124/311 (39%), Gaps = 20/311 (6%)

Query: 164 RLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWV 223
           RL     Q V +  +     +IG+  Q  + ++ LG V  LL  +      T L+    V
Sbjct: 13  RLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIV-LGAVPRLLYLLQQETSSTELKTECAV 71

Query: 224 MV-NLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWAL-SYLTDAGNEQIQMVI 281
           ++ +L    +          I+PAL   +   D+  +   +  L +  T     +  +  
Sbjct: 72  VLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYT 131

Query: 282 DSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEK 341
           D+ ++PHL+ LLS      Q    +   +   G D QT ++ N  A+ +   LLT    K
Sbjct: 132 DATVIPHLMALLSRSRY-TQEYICQIFSHCCKGPDHQT-ILFNHGAVQNIAHLLTSLSYK 189

Query: 342 INKEAVWFLSNITAGNQQ----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTI 397
           +  +A+   S +   N Q     V  ++D  L+P I   + + D   + +   A      
Sbjct: 190 VRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSA------ 243

Query: 398 SGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECG 457
                 + Y+ +   I    N + +K    + V +     +L+   + AET+  LIE   
Sbjct: 244 ----KCLTYMCRAGAIRTDDNCIVLKTLPCL-VRMCSKERLLEERVEGAETLAYLIEPDV 298

Query: 458 GLEKIEQLQNH 468
            L++I  + +H
Sbjct: 299 ELQRIASITDH 309


>gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens]
          Length = 385

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 67/311 (21%), Positives = 124/311 (39%), Gaps = 20/311 (6%)

Query: 164 RLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWV 223
           RL     Q V +  +     +IG+  Q  + ++ LG V  LL  +      T L+    V
Sbjct: 13  RLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIV-LGAVPRLLYLLQQETSSTELKTECAV 71

Query: 224 MV-NLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWAL-SYLTDAGNEQIQMVI 281
           ++ +L    +          I+PAL   +   D+  +   +  L +  T     +  +  
Sbjct: 72  VLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYT 131

Query: 282 DSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEK 341
           D+ ++PHL+ LLS      Q    +   +   G D QT ++ N  A+ +   LLT    K
Sbjct: 132 DATVIPHLMALLSRSRY-TQEYICQIFSHCCKGPDHQT-ILFNHGAVQNIAHLLTSLSYK 189

Query: 342 INKEAVWFLSNITAGNQQ----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTI 397
           +  +A+   S +   N Q     V  ++D  L+P I   + + D   + +   A      
Sbjct: 190 VRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSA------ 243

Query: 398 SGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECG 457
                 + Y+ +   I    N + +K    + V +     +L+   + AET+  LIE   
Sbjct: 244 ----KCLTYMCRAGAIRTDDNCIVLKTLPCL-VRMCSKERLLEERVEGAETLAYLIEPDV 298

Query: 458 GLEKIEQLQNH 468
            L++I  + +H
Sbjct: 299 ELQRIASITDH 309


>gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]
          Length = 659

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 67/311 (21%), Positives = 124/311 (39%), Gaps = 20/311 (6%)

Query: 164 RLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWV 223
           RL     Q V +  +     +IG+  Q  + ++ LG V  LL  +      T L+    V
Sbjct: 13  RLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIV-LGAVPRLLYLLQQETSSTELKTECAV 71

Query: 224 MV-NLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWAL-SYLTDAGNEQIQMVI 281
           ++ +L    +          I+PAL   +   D+  +   +  L +  T     +  +  
Sbjct: 72  VLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYT 131

Query: 282 DSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEK 341
           D+ ++PHL+ LLS      Q    +   +   G D QT ++ N  A+ +   LLT    K
Sbjct: 132 DATVIPHLMALLSRSRY-TQEYICQIFSHCCKGPDHQT-ILFNHGAVQNIAHLLTSLSYK 189

Query: 342 INKEAVWFLSNITAGNQQ----QVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTI 397
           +  +A+   S +   N Q     V  ++D  L+P I   + + D   + +   A      
Sbjct: 190 VRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSA------ 243

Query: 398 SGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECG 457
                 + Y+ +   I    N + +K    + V +     +L+   + AET+  LIE   
Sbjct: 244 ----KCLTYMCRAGAIRTDDNCIVLKTLPCL-VRMCSKERLLEERVEGAETLAYLIEPDV 298

Query: 458 GLEKIEQLQNH 468
            L++I  + +H
Sbjct: 299 ELQRIASITDH 309



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 39/219 (17%), Positives = 91/219 (41%), Gaps = 44/219 (20%)

Query: 104 NPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQA-VVQSNAVPLF 162
           +P  + +++SG + +L   L + +NP+L+    WAL N+A    ++ +A +++S +    
Sbjct: 444 SPSKEPILESGAVELLCG-LTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQL 502

Query: 163 LRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTW 222
            RLL     NV  + +  L N++   P     + + G                       
Sbjct: 503 FRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHG----------------------- 539

Query: 223 VMVNLCRHKDPPPPMETIQEILPALCVLIH-HTDVNILVDTVWALSYLTDAGNEQIQMVI 281
                             ++I+ A+ +++    ++ +   T+  L+ + D    +  ++ 
Sbjct: 540 ------------------KQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMT 581

Query: 282 DSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQ 320
           +  I+  +   + H  VK+Q AA+  + N++   +E +Q
Sbjct: 582 NDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQ 620


>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
          Length = 1149

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 12/121 (9%)

Query: 244 LPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTA 303
           LP +  ++ H   ++  +    L +L    N+    V   G + HLV LL H+ ++VQ  
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589

Query: 304 ALRAVGNIVTG--TDEQTQVVLNCDALSHFPALLTHPKEKINKE-------AVWFLSNIT 354
           A  A+ N+V G  TDE    + N   +   PALL   ++ I+ E        +W LS+  
Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGI---PALLRLLRKSIDAEVRELVTGVLWNLSSCD 646

Query: 355 A 355
           A
Sbjct: 647 A 647


>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
          Length = 1192

 Score = 40.4 bits (93), Expect = 0.004
 Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 12/121 (9%)

Query: 244 LPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTA 303
           LP +  ++ H   ++  +    L +L    N+    V   G + HLV LL H+ ++VQ  
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589

Query: 304 ALRAVGNIVTG--TDEQTQVVLNCDALSHFPALLTHPKEKINKE-------AVWFLSNIT 354
           A  A+ N+V G  TDE    + N   +   PALL   ++ I+ E        +W LS+  
Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGI---PALLRLLRKSIDAEVRELVTGVLWNLSSCD 646

Query: 355 A 355
           A
Sbjct: 647 A 647


>gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]
          Length = 1992

 Score = 40.0 bits (92), Expect = 0.005
 Identities = 48/228 (21%), Positives = 91/228 (39%), Gaps = 11/228 (4%)

Query: 70  NTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNP 129
           ++  + ++Q   + ++  QL AV    +LL       +       ++P L+  L+ + N 
Sbjct: 436 SSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNF 495

Query: 130 SLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPH-QNVCEQAVWALGNIIGDG 188
            +   A  ALT +       +  VV  +A+P+FL  L      +V EQA+ AL  +    
Sbjct: 496 DIMNHACRALTYMMEALPRSSAVVV--DAIPVFLEKLQVIQCIDVAEQALTALEML---S 550

Query: 189 PQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALC 248
            +    ++  G +   L ++     I   RN   +  N C+    P     + + LP L 
Sbjct: 551 RRHSKAILQAGGLADCLLYLE-FFSINAQRNALAIAANCCQ-SITPDEFHFVADSLPLLT 608

Query: 249 VLIHHTDVNILVDTVWALSYLTDAGNEQ---IQMVIDSGIVPHLVPLL 293
             + H D   +  T    + L D    +   +Q V    ++ ++  LL
Sbjct: 609 QRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLL 656


>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 39.3 bits (90), Expect = 0.009
 Identities = 39/211 (18%), Positives = 82/211 (38%), Gaps = 6/211 (2%)

Query: 195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHT 254
           +   G +  L+  +   +       +T  + NL  H++       +   L  +  L++ T
Sbjct: 231 IFKSGGIPALVKMLGSPVDSVLFYAIT-TLHNLLLHQEGAKMAVRLAGGLQKMVALLNKT 289

Query: 255 DVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTG 314
           +V  L  T   L  L     E   +++ SG    LV ++     +        V  +++ 
Sbjct: 290 NVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSV 349

Query: 315 TDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNIT-AGNQQQVQAVIDANLVPMI 373
                  ++    +      LT P +++ +  +W L N++ A  +Q+        L+  +
Sbjct: 350 CSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGM----EGLLGTL 405

Query: 374 IHLLDKGDFGTQKEAAWAISNLTISGRKDQV 404
           + LL   D      AA  +SNLT +  K+++
Sbjct: 406 VQLLGSDDINVVTCAAGILSNLTCNNYKNKM 436


>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 39.3 bits (90), Expect = 0.009
 Identities = 39/211 (18%), Positives = 82/211 (38%), Gaps = 6/211 (2%)

Query: 195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHT 254
           +   G +  L+  +   +       +T  + NL  H++       +   L  +  L++ T
Sbjct: 231 IFKSGGIPALVKMLGSPVDSVLFYAIT-TLHNLLLHQEGAKMAVRLAGGLQKMVALLNKT 289

Query: 255 DVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTG 314
           +V  L  T   L  L     E   +++ SG    LV ++     +        V  +++ 
Sbjct: 290 NVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSV 349

Query: 315 TDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNIT-AGNQQQVQAVIDANLVPMI 373
                  ++    +      LT P +++ +  +W L N++ A  +Q+        L+  +
Sbjct: 350 CSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGM----EGLLGTL 405

Query: 374 IHLLDKGDFGTQKEAAWAISNLTISGRKDQV 404
           + LL   D      AA  +SNLT +  K+++
Sbjct: 406 VQLLGSDDINVVTCAAGILSNLTCNNYKNKM 436


>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score = 39.3 bits (90), Expect = 0.009
 Identities = 39/211 (18%), Positives = 82/211 (38%), Gaps = 6/211 (2%)

Query: 195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHT 254
           +   G +  L+  +   +       +T  + NL  H++       +   L  +  L++ T
Sbjct: 231 IFKSGGIPALVKMLGSPVDSVLFYAIT-TLHNLLLHQEGAKMAVRLAGGLQKMVALLNKT 289

Query: 255 DVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTG 314
           +V  L  T   L  L     E   +++ SG    LV ++     +        V  +++ 
Sbjct: 290 NVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSV 349

Query: 315 TDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNIT-AGNQQQVQAVIDANLVPMI 373
                  ++    +      LT P +++ +  +W L N++ A  +Q+        L+  +
Sbjct: 350 CSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGM----EGLLGTL 405

Query: 374 IHLLDKGDFGTQKEAAWAISNLTISGRKDQV 404
           + LL   D      AA  +SNLT +  K+++
Sbjct: 406 VQLLGSDDINVVTCAAGILSNLTCNNYKNKM 436


>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
          Length = 1363

 Score = 38.9 bits (89), Expect = 0.012
 Identities = 53/287 (18%), Positives = 114/287 (39%), Gaps = 14/287 (4%)

Query: 135 AAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 194
           A  +L  I     +  + ++ +  +P  + LL S    +  + V  L NI          
Sbjct: 649 AVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNI-STHKSAVHA 707

Query: 195 VISLGVVKPLLSFISPSIPITFLR-NVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHH 253
           ++  G +  L++ +    P    R  V    +  C +KD       I    P+L  L++ 
Sbjct: 708 LVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENKDVIAKYNGI----PSLINLLNL 763

Query: 254 TDVNILVDTVWALSYLTDAGNEQIQMVI-DSGIVPHLVPLLSHQEVKVQTAALRAVGNIV 312
              N+LV+ +  +  L   GNE  Q  + +   +P+L+  LS     ++  +  A+  + 
Sbjct: 764 NIENVLVNVMNCIRVLC-IGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVG 822

Query: 313 TGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPM 372
               E    +    A+    AL    +  +  +    + ++ + N    +A ++ +L   
Sbjct: 823 RDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKY 882

Query: 373 IIHLLDKGDFGTQKEAA---WAISNLTISGRK---DQVAYLIQQNVI 413
           ++ LL       +++ A   WA++  T+  +K   +Q+ Y    N++
Sbjct: 883 LLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGYSFIINML 929



 Score = 35.0 bits (79), Expect = 0.17
 Identities = 36/157 (22%), Positives = 66/157 (42%), Gaps = 24/157 (15%)

Query: 31   EVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLS 90
            E V+ L K+ R         +    ICE + I    R+   S  A         +G  LS
Sbjct: 942  EAVIALSKDSR---------MHQNQICEGNGIAPLVRLLRISTIA---------EGTLLS 983

Query: 91   AVQAARKL---LSSDRNPPIDD-LIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGT 146
             ++A   +   ++   NP     ++     P+L+  L    +P+++ E A++L  I  G 
Sbjct: 984  VIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEVAFSLACIVLGN 1043

Query: 147  SEQTQAVVQSNAVPL--FLRLLHSPHQNVCEQAVWAL 181
                + + ++        L LLHS  +++C +A +AL
Sbjct: 1044 DVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYAL 1080


>gi|209969838 transportin 2 (importin 3, karyopherin beta 2b)
           isoform 1 [Homo sapiens]
          Length = 897

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 55/227 (24%), Positives = 93/227 (40%), Gaps = 27/227 (11%)

Query: 264 WALSYLTDAGNEQIQMVIDSGIVPHLVPLLS----HQEVKVQTAALRAVGNIVTGTDEQT 319
           W L   + A  + +  V    ++PHL+PLL     H E  V+ + +  +G I  G   Q 
Sbjct: 370 WNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGC-MQG 428

Query: 320 QVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDK 379
            V    + + H    L+  K  +   A W LS         V    D +L P++  LL +
Sbjct: 429 MVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA---HWVVSQPPDMHLKPLMTELLKR 485

Query: 380 ---GDFGTQKEAAWAISNLTISGRKDQVAYL--IQQNVIPPF-----CNLLTVKDAQVVQ 429
              G+   Q+ A  A + L      + V YL  I   ++  F      NLL + DA  + 
Sbjct: 486 ILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDA--IG 543

Query: 430 VVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKL 476
            + D + + L   E   + +  LI++   L+        E++D++ L
Sbjct: 544 TLADSVGHHLNQPEYIQKLMPPLIQKWNELK-------DEDKDLFPL 583



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 27/110 (24%), Positives = 52/110 (47%), Gaps = 6/110 (5%)

Query: 112 KSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ 171
           +S I+ +L  C++ D  P ++  +   L ++        +  + +  +P+    L+    
Sbjct: 662 RSNIMTLLFQCMQ-DSMPEVRQSSFALLGDLTKACFIHVKPCI-AEFMPILGTNLNPEFI 719

Query: 172 NVCEQAVWALGNI-IGDGPQCRDYVISLGVVKPLLSFIS-PSIPITFLRN 219
           +VC  A WA+G I +  G + + YV    V+  L+  I+ P+ P T L N
Sbjct: 720 SVCNNATWAIGEICMQMGAEMQPYVQM--VLNNLVEIINRPNTPKTLLEN 767


>gi|209969836 transportin 2 (importin 3, karyopherin beta 2b)
           isoform 3 [Homo sapiens]
          Length = 887

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 55/227 (24%), Positives = 93/227 (40%), Gaps = 27/227 (11%)

Query: 264 WALSYLTDAGNEQIQMVIDSGIVPHLVPLLS----HQEVKVQTAALRAVGNIVTGTDEQT 319
           W L   + A  + +  V    ++PHL+PLL     H E  V+ + +  +G I  G   Q 
Sbjct: 370 WNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGC-MQG 428

Query: 320 QVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDK 379
            V    + + H    L+  K  +   A W LS         V    D +L P++  LL +
Sbjct: 429 MVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA---HWVVSQPPDMHLKPLMTELLKR 485

Query: 380 ---GDFGTQKEAAWAISNLTISGRKDQVAYL--IQQNVIPPF-----CNLLTVKDAQVVQ 429
              G+   Q+ A  A + L      + V YL  I   ++  F      NLL + DA  + 
Sbjct: 486 ILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDA--IG 543

Query: 430 VVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKL 476
            + D + + L   E   + +  LI++   L+        E++D++ L
Sbjct: 544 TLADSVGHHLNQPEYIQKLMPPLIQKWNELK-------DEDKDLFPL 583



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 31/144 (21%), Positives = 64/144 (44%), Gaps = 7/144 (4%)

Query: 112 KSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ 171
           +S I+ +L  C++ D  P ++  +   L ++        +  + +  +P+    L+    
Sbjct: 662 RSNIMTLLFQCMQ-DSMPEVRQSSFALLGDLTKACFIHVKPCI-AEFMPILGTNLNPEFI 719

Query: 172 NVCEQAVWALGNI-IGDGPQCRDYVISLGVVKPLLSFIS-PSIPITFLRNVTWVMVNLCR 229
           +VC  A WA+G I +  G + + YV    V+  L+  I+ P+ P T L N T + +    
Sbjct: 720 SVCNNATWAIGEICMQMGAEMQPYVQM--VLNNLVEIINRPNTPKTLLEN-TAITIGRLG 776

Query: 230 HKDPPPPMETIQEILPALCVLIHH 253
           +  P      +Q+ +   C  + +
Sbjct: 777 YVCPQEVAPMLQQFIRPWCTSLRN 800


>gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isoform
           2 [Homo sapiens]
          Length = 887

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 55/227 (24%), Positives = 93/227 (40%), Gaps = 27/227 (11%)

Query: 264 WALSYLTDAGNEQIQMVIDSGIVPHLVPLLS----HQEVKVQTAALRAVGNIVTGTDEQT 319
           W L   + A  + +  V    ++PHL+PLL     H E  V+ + +  +G I  G   Q 
Sbjct: 370 WNLRKCSAAALDVLANVFREELLPHLLPLLKGLLFHPEWVVKESGILVLGAIAEGC-MQG 428

Query: 320 QVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDK 379
            V    + + H    L+  K  +   A W LS         V    D +L P++  LL +
Sbjct: 429 MVPYLPELIPHLIQCLSDKKALVRSIACWTLSRYA---HWVVSQPPDMHLKPLMTELLKR 485

Query: 380 ---GDFGTQKEAAWAISNLTISGRKDQVAYL--IQQNVIPPF-----CNLLTVKDAQVVQ 429
              G+   Q+ A  A + L      + V YL  I   ++  F      NLL + DA  + 
Sbjct: 486 ILDGNKRVQEAACSAFATLEEEACTELVPYLSYILDTLVFAFGKYQHKNLLILYDA--IG 543

Query: 430 VVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKL 476
            + D + + L   E   + +  LI++   L+        E++D++ L
Sbjct: 544 TLADSVGHHLNQPEYIQKLMPPLIQKWNELK-------DEDKDLFPL 583



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 31/144 (21%), Positives = 64/144 (44%), Gaps = 7/144 (4%)

Query: 112 KSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ 171
           +S I+ +L  C++ D  P ++  +   L ++        +  + +  +P+    L+    
Sbjct: 662 RSNIMTLLFQCMQ-DSMPEVRQSSFALLGDLTKACFIHVKPCI-AEFMPILGTNLNPEFI 719

Query: 172 NVCEQAVWALGNI-IGDGPQCRDYVISLGVVKPLLSFIS-PSIPITFLRNVTWVMVNLCR 229
           +VC  A WA+G I +  G + + YV    V+  L+  I+ P+ P T L N T + +    
Sbjct: 720 SVCNNATWAIGEICMQMGAEMQPYVQM--VLNNLVEIINRPNTPKTLLEN-TAITIGRLG 776

Query: 230 HKDPPPPMETIQEILPALCVLIHH 253
           +  P      +Q+ +   C  + +
Sbjct: 777 YVCPQEVAPMLQQFIRPWCTSLRN 800


>gi|4502247 armadillo repeat protein [Homo sapiens]
          Length = 962

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 26/107 (24%), Positives = 49/107 (45%), Gaps = 1/107 (0%)

Query: 333 ALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAI 392
           A+L HP + +   A  +L ++   N+   + V     +P+++ LLD      ++ A  A+
Sbjct: 365 AMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGAL 424

Query: 393 SNLTISGRKDQVAYLIQQNVIPPFCNLL-TVKDAQVVQVVLDGLSNI 438
            NL+     D  A +     +P    LL   +D +V ++V   L N+
Sbjct: 425 RNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNL 471



 Score = 32.7 bits (73), Expect = 0.83
 Identities = 23/93 (24%), Positives = 42/93 (45%), Gaps = 1/93 (1%)

Query: 286 VPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKE 345
           +P ++ +L H    V+  A   + ++    +   + V     L    ALL HP+ ++ + 
Sbjct: 360 LPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRR 419

Query: 346 AVWFLSNITAGNQQQVQAVI-DANLVPMIIHLL 377
           A   L N++ G     +A I D   VP ++ LL
Sbjct: 420 ACGALRNLSYGRDTDNKAAIRDCGGVPALVRLL 452


>gi|28875784 armadillo repeat containing 5 isoform b [Homo sapiens]
          Length = 725

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 30/98 (30%), Positives = 48/98 (48%), Gaps = 6/98 (6%)

Query: 114 GILPI--LVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ 171
           GILP+  ++ C++ D   S+Q   A AL N+A    E    +  + AVPL +  L +   
Sbjct: 154 GILPLVTILQCMKTD---SIQNRTARALGNLAM-EPESCGDIHCAGAVPLLVESLTACQD 209

Query: 172 NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFIS 209
           + C Q+V      + D PQ R  +   G V+PL   ++
Sbjct: 210 SQCLQSVVRALRNLADSPQHRLALAQQGAVRPLAELLA 247



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 36/185 (19%), Positives = 68/185 (36%), Gaps = 9/185 (4%)

Query: 191 CRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVL 250
           CR  V  LG + PL++ +      +        + NL    +    +     +   +  L
Sbjct: 145 CRTEVRRLGGILPLVTILQCMKTDSIQNRTARALGNLAMEPESCGDIHCAGAVPLLVESL 204

Query: 251 IHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGN 310
               D   L   V AL  L D+   ++ +     + P    L +  +  +  A +RA+  
Sbjct: 205 TACQDSQCLQSVVRALRNLADSPQHRLALAQQGAVRPLAELLATAPDAALTLALVRALLE 264

Query: 311 IVTGTDEQTQVVLNCDA-LSHFPALLTHPKEKINKEAVWFLSNITA--------GNQQQV 361
           +  G        L+    L    +L +HPK  + +  +  L+N+ A        GN   V
Sbjct: 265 LSRGCSRACAEQLSLGGGLGPLVSLASHPKRAVREGTILILANLCAQGLIRPALGNAGGV 324

Query: 362 QAVID 366
           + ++D
Sbjct: 325 EVLVD 329


>gi|157426856 armadillo repeat containing 5 isoform a [Homo sapiens]
          Length = 935

 Score = 37.7 bits (86), Expect = 0.026
 Identities = 30/98 (30%), Positives = 48/98 (48%), Gaps = 6/98 (6%)

Query: 114 GILPI--LVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQ 171
           GILP+  ++ C++ D   S+Q   A AL N+A    E    +  + AVPL +  L +   
Sbjct: 154 GILPLVTILQCMKTD---SIQNRTARALGNLAM-EPESCGDIHCAGAVPLLVESLTACQD 209

Query: 172 NVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFIS 209
           + C Q+V      + D PQ R  +   G V+PL   ++
Sbjct: 210 SQCLQSVVRALRNLADSPQHRLALAQQGAVRPLAELLA 247



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 36/185 (19%), Positives = 68/185 (36%), Gaps = 9/185 (4%)

Query: 191 CRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVL 250
           CR  V  LG + PL++ +      +        + NL    +    +     +   +  L
Sbjct: 145 CRTEVRRLGGILPLVTILQCMKTDSIQNRTARALGNLAMEPESCGDIHCAGAVPLLVESL 204

Query: 251 IHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGN 310
               D   L   V AL  L D+   ++ +     + P    L +  +  +  A +RA+  
Sbjct: 205 TACQDSQCLQSVVRALRNLADSPQHRLALAQQGAVRPLAELLATAPDAALTLALVRALLE 264

Query: 311 IVTGTDEQTQVVLNCDA-LSHFPALLTHPKEKINKEAVWFLSNITA--------GNQQQV 361
           +  G        L+    L    +L +HPK  + +  +  L+N+ A        GN   V
Sbjct: 265 LSRGCSRACAEQLSLGGGLGPLVSLASHPKRAVREGTILILANLCAQGLIRPALGNAGGV 324

Query: 362 QAVID 366
           + ++D
Sbjct: 325 EVLVD 329


>gi|154090976 sterile alpha and TIR motif containing 1 [Homo
           sapiens]
          Length = 724

 Score = 37.4 bits (85), Expect = 0.034
 Identities = 46/196 (23%), Positives = 80/196 (40%), Gaps = 16/196 (8%)

Query: 134 EAAWALTNIASGTSEQT-QAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCR 192
           E AW L  +    ++    A+     + L LRLL +P      QA   L  I+    + R
Sbjct: 100 EEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDR 159

Query: 193 DYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEI-----LPAL 247
              I LGV+   L+      P+   R+V  ++ ++ +H +     ET Q +     L A+
Sbjct: 160 VARIGLGVI---LNLAKEREPVELARSVAGILEHMFKHSE-----ETCQRLVAAGGLDAV 211

Query: 248 CVLIHHTDVNILVDTVWALSYLTDAGNEQIQ-MVIDSGIVPHLVPL-LSHQEVKVQTAAL 305
                 TD  +L     AL      G + +Q  +++      L PL  S ++  ++  A 
Sbjct: 212 LYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHAC 271

Query: 306 RAVGNIVTGTDEQTQV 321
            AV  + T  + + +V
Sbjct: 272 LAVAVLATNKEVEREV 287


>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
           [Homo sapiens]
          Length = 558

 Score = 37.0 bits (84), Expect = 0.044
 Identities = 66/320 (20%), Positives = 131/320 (40%), Gaps = 33/320 (10%)

Query: 99  LSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNA 158
           L+ +     + +  SGIL +    L      S + + A  +  +A     +   V     
Sbjct: 34  LAQNNTETSEKIQASGILQLFASLLTPQS--SCKAKVANIIAEVAKNEFMRIPCVDAGLI 91

Query: 159 VPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLR 218
            PL ++LL+S  Q V  Q   ALGNI  D    +  +I++GV+  L+  +        L 
Sbjct: 92  SPL-VQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALT 150

Query: 219 NVTWV----MVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGN 274
            +  V    +  L   K+        +E++      I H    ++ + +  L     A N
Sbjct: 151 EMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPL-----AEN 205

Query: 275 EQIQM-VIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDAL----- 328
           + I++ ++++G+V  L+ ++   + KV +     +  + TG+D    ++L  +++     
Sbjct: 206 DAIKLQLVEAGLVECLLEIV---QQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFE 262

Query: 329 ----SHFPALLT---HPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDK-- 379
               S F  +L+       ++       ++N  A N      ++D  +V  ++ LLD+  
Sbjct: 263 GGKGSVFQRVLSWIPSNNHQLQLAGALAIANF-ARNDANCIHMVDNGIVEKLMDLLDRHV 321

Query: 380 --GDFGTQKEAAWAISNLTI 397
             G+   Q  A  A+ NL I
Sbjct: 322 EDGNVTVQHAALSALRNLAI 341


>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
           [Homo sapiens]
          Length = 559

 Score = 37.0 bits (84), Expect = 0.044
 Identities = 66/320 (20%), Positives = 131/320 (40%), Gaps = 33/320 (10%)

Query: 99  LSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNA 158
           L+ +     + +  SGIL +    L      S + + A  +  +A     +   V     
Sbjct: 35  LAQNNTETSEKIQASGILQLFASLLTPQS--SCKAKVANIIAEVAKNEFMRIPCVDAGLI 92

Query: 159 VPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLR 218
            PL ++LL+S  Q V  Q   ALGNI  D    +  +I++GV+  L+  +        L 
Sbjct: 93  SPL-VQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALT 151

Query: 219 NVTWV----MVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGN 274
            +  V    +  L   K+        +E++      I H    ++ + +  L     A N
Sbjct: 152 EMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPL-----AEN 206

Query: 275 EQIQM-VIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDAL----- 328
           + I++ ++++G+V  L+ ++   + KV +     +  + TG+D    ++L  +++     
Sbjct: 207 DAIKLQLVEAGLVECLLEIV---QQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFE 263

Query: 329 ----SHFPALLT---HPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDK-- 379
               S F  +L+       ++       ++N  A N      ++D  +V  ++ LLD+  
Sbjct: 264 GGKGSVFQRVLSWIPSNNHQLQLAGALAIANF-ARNDANCIHMVDNGIVEKLMDLLDRHV 322

Query: 380 --GDFGTQKEAAWAISNLTI 397
             G+   Q  A  A+ NL I
Sbjct: 323 EDGNVTVQHAALSALRNLAI 342


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,891,756
Number of Sequences: 37866
Number of extensions: 860873
Number of successful extensions: 2659
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 2381
Number of HSP's gapped (non-prelim): 163
length of query: 521
length of database: 18,247,518
effective HSP length: 107
effective length of query: 414
effective length of database: 14,195,856
effective search space: 5877084384
effective search space used: 5877084384
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.