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Search of human proteins with 4504505
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo
sapiens]
(736 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 1466 0.0
gi|30425406 hypothetical protein LOC140856 [Homo sapiens] 124 2e-28
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 102 2e-21
gi|19923233 sterol carrier protein 2 isoform 1 proprotein [Homo ... 89 2e-17
gi|55956779 sterol carrier protein 2 isoform 2 precursor [Homo s... 89 2e-17
gi|55956777 sterol carrier protein 2 isoform 1 precursor [Homo s... 89 2e-17
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 87 4e-17
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 84 5e-16
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 82 2e-15
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 81 3e-15
gi|40254992 carbonic reductase 4 [Homo sapiens] 80 7e-15
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 78 3e-14
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 78 3e-14
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 72 2e-12
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 72 2e-12
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 70 5e-12
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 69 2e-11
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 68 3e-11
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 67 5e-11
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 66 1e-10
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 66 1e-10
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 64 7e-10
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ... 62 2e-09
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 61 4e-09
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 61 4e-09
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 60 6e-09
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens] 60 7e-09
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo... 59 2e-08
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ... 59 2e-08
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 57 5e-08
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 1466 bits (3795), Expect = 0.0
Identities = 736/736 (100%), Positives = 736/736 (100%)
Query: 1 MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE 60
MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE
Sbjct: 1 MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE 60
Query: 61 EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH 120
EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH
Sbjct: 61 EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIH 120
Query: 121 RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI 180
RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI
Sbjct: 121 RVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI 180
Query: 181 EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG 240
EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG
Sbjct: 181 EGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVG 240
Query: 241 AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS 300
AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS
Sbjct: 241 AGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLS 300
Query: 301 KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD 360
KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD
Sbjct: 301 KIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKD 360
Query: 361 LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA 420
LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA
Sbjct: 361 LKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRA 420
Query: 421 GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV 480
GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV
Sbjct: 421 GKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKV 480
Query: 481 AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS 540
AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS
Sbjct: 481 AVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFS 540
Query: 541 ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN 600
ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN
Sbjct: 541 ARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISN 600
Query: 601 AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI 660
AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI
Sbjct: 601 AYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNI 660
Query: 661 GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI 720
GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI
Sbjct: 661 GAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNI 720
Query: 721 MLSQKLQMILKDYAKL 736
MLSQKLQMILKDYAKL
Sbjct: 721 MLSQKLQMILKDYAKL 736
>gi|30425406 hypothetical protein LOC140856 [Homo sapiens]
Length = 156
Score = 124 bits (312), Expect = 2e-28
Identities = 67/160 (41%), Positives = 100/160 (62%), Gaps = 6/160 (3%)
Query: 577 MWKEGNRIHFQTKVQ-ETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRL 635
MWK + Q K++ E G +V + L + P E + +S VF++I +
Sbjct: 1 MWKRSDH---QPKIKAEDGPLV--GQFEVLGSVPEPAMPHPLELSEFESFPVFQDIRLHI 55
Query: 636 KDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDF 695
+++G ++VKKVNAVF+ ITK G +WTIDLK+GSG +Y GPA+ ADT + + F
Sbjct: 56 REVGAQLVKKVNAVFQLDITKNGKTILRWTIDLKNGSGDMYPGPARLPADTVFTIPESVF 115
Query: 696 MEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAK 735
ME+VLGK++PQKAF +G+ K G ++LS KL+ + KD+AK
Sbjct: 116 MELVLGKMNPQKAFLAGKFKVSGKVLLSWKLERVFKDWAK 155
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 102 bits (253), Expect = 2e-21
Identities = 86/263 (32%), Positives = 124/263 (47%), Gaps = 41/263 (15%)
Query: 6 RFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRR 65
R + LVTGAG+G+GRA ++ A GA V DL AA + V +
Sbjct: 8 RLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLD---------RAAAQETVRLLGGP 58
Query: 66 GGKA----------VANYDSVEEGEKVVKTALDAFGRI-DVVVNNAGILRDRSFARISDE 114
G K A+ +++ F R VVV+ AGI +D +S++
Sbjct: 59 GSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSED 118
Query: 115 DWDIIHRVHLRGSFQVTRAAWEHMKKQKY-GRIIMTSSASGIYGNFGQANYSAAKLGLLG 173
DWD + V+L+G+F VT+AA + + G II SS G GN GQ NY+A+K G++G
Sbjct: 119 DWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIG 178
Query: 174 LANSLAIEGRKSNIHCNTIAPN-AGSRMTQTVMPEDLVEAL----------KPEYVAPLV 222
L + A E + I CN++ P + MTQ V P+ +V+ + PE VA +V
Sbjct: 179 LTQTAARELGRHGIRCNSVLPGFIATPMTQKV-PQKVVDKITEMIPMGHLGDPEDVADVV 237
Query: 223 LWLCHE--------SCEENGGLF 237
+L E S E GGLF
Sbjct: 238 AFLASEDSGYITGTSVEVTGGLF 260
>gi|19923233 sterol carrier protein 2 isoform 1 proprotein [Homo
sapiens]
Length = 547
Score = 88.6 bits (218), Expect = 2e-17
Identities = 45/114 (39%), Positives = 70/114 (61%), Gaps = 2/114 (1%)
Query: 615 TPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKG-GNIGAKWTIDLKSGSG 673
T S ++ VF+EI ++L++ G + VKK+ +F + + G G A W +D+K+G G
Sbjct: 424 TSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKG 483
Query: 674 KVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQ 727
V K AD TI ++D DF+ ++ GK++PQ AFF G+LK GN+ L+ KLQ
Sbjct: 484 SVLPNSDK-KADCTITMADSDFLALMTGKMNPQSAFFQGKLKITGNMGLAMKLQ 536
>gi|55956779 sterol carrier protein 2 isoform 2 precursor [Homo
sapiens]
Length = 140
Score = 88.6 bits (218), Expect = 2e-17
Identities = 45/114 (39%), Positives = 70/114 (61%), Gaps = 2/114 (1%)
Query: 615 TPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKG-GNIGAKWTIDLKSGSG 673
T S ++ VF+EI ++L++ G + VKK+ +F + + G G A W +D+K+G G
Sbjct: 17 TSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKG 76
Query: 674 KVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQ 727
V K AD TI ++D DF+ ++ GK++PQ AFF G+LK GN+ L+ KLQ
Sbjct: 77 SVLPNSDK-KADCTITMADSDFLALMTGKMNPQSAFFQGKLKITGNMGLAMKLQ 129
>gi|55956777 sterol carrier protein 2 isoform 1 precursor [Homo
sapiens]
Length = 143
Score = 88.6 bits (218), Expect = 2e-17
Identities = 45/114 (39%), Positives = 70/114 (61%), Gaps = 2/114 (1%)
Query: 615 TPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKG-GNIGAKWTIDLKSGSG 673
T S ++ VF+EI ++L++ G + VKK+ +F + + G G A W +D+K+G G
Sbjct: 20 TSSASDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKG 79
Query: 674 KVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQ 727
V K AD TI ++D DF+ ++ GK++PQ AFF G+LK GN+ L+ KLQ
Sbjct: 80 SVLPNSDK-KADCTITMADSDFLALMTGKMNPQSAFFQGKLKITGNMGLAMKLQ 132
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 87.4 bits (215), Expect = 4e-17
Identities = 55/190 (28%), Positives = 93/190 (48%), Gaps = 16/190 (8%)
Query: 6 RFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRR 65
R DG+V+++T A G+G+A ALAFA GA V+ D+ + ++E+ +
Sbjct: 3 RLDGKVIILTAAAQGIGQAAALAFAREGAKVIATDIN-------------ESKLQELEKY 49
Query: 66 GGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLR 125
G D + +K + + R+DV+ N AG + + ++DWD +++R
Sbjct: 50 PGIQTRVLDVTK--KKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVR 107
Query: 126 GSFQVTRAAWEHMKKQKYGRII-MTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRK 184
+ + +A M QK G II M+S AS + G + YS K ++GL S+A + +
Sbjct: 108 SMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ 167
Query: 185 SNIHCNTIAP 194
I CN + P
Sbjct: 168 QGIRCNCVCP 177
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 84.0 bits (206), Expect = 5e-16
Identities = 70/238 (29%), Positives = 107/238 (44%), Gaps = 31/238 (13%)
Query: 9 GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGG---------------DFKGVGKGSL 53
G+V L+TGAG+GLGR +AL FA R AL+V+ D+ D + +L
Sbjct: 36 GQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAAL 95
Query: 54 AADKVVEEIRRRGGKAVANYD-SVEEGEKVVKTA---LDAFGRIDVVVNNAGILRDRSFA 109
A EEI V Y V + E V TA G + V+VNNAG++
Sbjct: 96 QAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLL 155
Query: 110 RISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKL 169
DE + V+ F T+A M + +G I+ +S+ G++ G +Y A+K
Sbjct: 156 ECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKF 215
Query: 170 GLLGLANSLAIE-------GRKSNIHCNTIAPNA---GSRMTQTVMPEDLVEALKPEY 217
G++G SL+ E G K+ + C + G R+ + + P + LKP+Y
Sbjct: 216 GVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEP--FLPPLKPDY 271
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 81.6 bits (200), Expect = 2e-15
Identities = 63/236 (26%), Positives = 107/236 (45%), Gaps = 23/236 (9%)
Query: 4 PLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIR 63
PL G V+VTG +G+G+ A+ ++GA + + D L K E+
Sbjct: 27 PLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNED-------KLLQAKKEIEMH 79
Query: 64 RRGGKAVANYDSVE------EGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWD 117
K V SV+ + E V+K A + G +D++VN AG+ F + ++
Sbjct: 80 SINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFE 139
Query: 118 IIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANS 177
+ ++ GS +RA MK+++ GRI+ SS +G G FG YSA+K + GLA +
Sbjct: 140 RLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEA 199
Query: 178 LAIEGRKSNIHCNTIAP----------NAGSRMTQTVMPEDLVEALKPEYVAPLVL 223
L +E + N++ P ++ +T + + KPE VA ++
Sbjct: 200 LQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIV 255
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 81.3 bits (199), Expect = 3e-15
Identities = 74/255 (29%), Positives = 119/255 (46%), Gaps = 26/255 (10%)
Query: 10 RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKA 69
+V LVT + G+G A A A+ GA VVV+ + D+ V ++ G
Sbjct: 33 KVALVTASTDGIGFAIARRLAQDGAHVVVSS---------RKQQNVDQAVATLQGEGLSV 83
Query: 70 ---VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRD-RSFARISDEDWDIIHRVHLR 125
V + E+ E++V TA+ G ID++V+NA + S +++E WD ++++
Sbjct: 84 TGTVCHVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVK 143
Query: 126 GSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKS 185
+T+A M+K+ G +++ SS + + G + Y+ +K LLGL +LAIE
Sbjct: 144 APALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPR 203
Query: 186 NIHCNTIAP----NAGSRM--TQTVMPEDLVEALK------PEYVAPLVLWLCHESCEE- 232
NI N +AP + SRM E + E L+ PE A +V +LC E
Sbjct: 204 NIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFLCSEDASYI 263
Query: 233 NGGLFEVGAGWIGKL 247
G VG G +L
Sbjct: 264 TGETVVVGGGTPSRL 278
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 80.1 bits (196), Expect = 7e-15
Identities = 66/202 (32%), Positives = 91/202 (45%), Gaps = 13/202 (6%)
Query: 10 RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKA 69
+V V G G+GRA A A +G + V + G L D +
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 62
Query: 70 VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQ 129
V N + EE EK + GR++ +VN AGI RD R ED +L GS
Sbjct: 63 VQN--TFEELEKHL-------GRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSML 113
Query: 130 VTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHC 189
+AA M +Q+ G I+ S G+ GN GQ+ YSA+K GL+G + +LA E + I
Sbjct: 114 TCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRV 173
Query: 190 NTIAPNAGSRMTQTVMPEDLVE 211
N +AP T M +DL E
Sbjct: 174 NVVAPG----FVHTDMTKDLKE 191
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 78.2 bits (191), Expect = 3e-14
Identities = 67/232 (28%), Positives = 109/232 (46%), Gaps = 26/232 (11%)
Query: 9 GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGK 68
G +VL TGAG+GLGR A+ FA GA++V+ D+ + G++ ++ +E +GGK
Sbjct: 36 GEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQE------GNMETCRLAKE---KGGK 86
Query: 69 AVANY----DSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHL 124
V Y + +E +V FG + ++VNNA ++ + F I D + V+
Sbjct: 87 KVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNA 146
Query: 125 RGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQAN-------YSAAKLGLLGLANS 177
F +A + K +G ++ SS +G+ G G ++ YSA+K G A S
Sbjct: 147 ITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAES 206
Query: 178 LAIE---GRKSNIHCNTIAP---NAGSRMTQTVMPEDLVEALKPEYVAPLVL 223
L E +K+ + + P N G T L+ L+ EYVA +L
Sbjct: 207 LFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILEQEYVAKKIL 258
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 78.2 bits (191), Expect = 3e-14
Identities = 62/226 (27%), Positives = 102/226 (45%), Gaps = 21/226 (9%)
Query: 9 GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGK 68
G +VL+TGAG+GLGR AL FA G+++V+ D+ + ++ + R G
Sbjct: 40 GEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKE---------GNEETCKMAREAGAT 90
Query: 69 AVANYD---SVEEGE-KVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHL 124
V Y S +EG +V G + +++NNAGI+ + F DE + V+
Sbjct: 91 RVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNF 150
Query: 125 RGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIE--- 181
+ +A M +G ++ SS++G+ G G A+Y A+K G A S+ +E
Sbjct: 151 KAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFV 210
Query: 182 ----GRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVL 223
G K+ I C T P L+ L+P+Y ++
Sbjct: 211 QKQKGIKTTIVCPFFIKTGMFEGCTTGCP-SLLPILEPKYAVEKIV 255
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 72.0 bits (175), Expect = 2e-12
Identities = 59/199 (29%), Positives = 95/199 (47%), Gaps = 16/199 (8%)
Query: 3 SPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEI 62
+P G+V +VTG G+G+A E G+ VV+ + + + AAD++ +
Sbjct: 12 APGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIAS-----RKLERLKSAADELQANL 66
Query: 63 ----RRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDI 118
+ R N + EE +VK+ LD FG+I+ +VNN G IS + W
Sbjct: 67 PPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHA 126
Query: 119 IHRVHLRGSFQVTRAAWEHMKKQKYGRI--IMTSSASGIYGNFGQANYS-AAKLGLLGLA 175
+ +L G+F + +A + K+ G I I+ + +G F A +S AA+ G+ L
Sbjct: 127 VLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAG----FPLAVHSGAARAGVYNLT 182
Query: 176 NSLAIEGRKSNIHCNTIAP 194
SLA+E S I N +AP
Sbjct: 183 KSLALEWACSGIRINCVAP 201
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 71.6 bits (174), Expect = 2e-12
Identities = 51/183 (27%), Positives = 87/183 (47%), Gaps = 18/183 (9%)
Query: 550 DNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIV-ISNAYVDLAPT 608
D ++ + + I+ + PG LQ + + + KV+ TG + + L P
Sbjct: 245 DENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPK 304
Query: 609 SGTSAKTPSEGGKLQSTFVFEEIGRRLKD-IGPEVVKKVNAVFEWHITKGGNIGAKWTID 667
+ A EE R +KD + +VVK A++ + ++ G G W +D
Sbjct: 305 PRSGA--------------VEETFRIVKDSLSDDVVKATQAIYLFELS--GEDGGTWFLD 348
Query: 668 LKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQ 727
LKS G V G AD + ++ +DF+++ GKL P AF SG+LK +GN+ L+ KL+
Sbjct: 349 LKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLE 408
Query: 728 MIL 730
++
Sbjct: 409 KLM 411
Score = 63.9 bits (154), Expect = 5e-10
Identities = 56/198 (28%), Positives = 94/198 (47%), Gaps = 16/198 (8%)
Query: 6 RFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRR 65
R G V +TGA G+G+A AL A+ GA +V+ G++ EEI
Sbjct: 7 RLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYT--AAEEIEAV 64
Query: 66 GGKAVANYDSVEEGEKV---VKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRV 122
GGKA+ V + +++ V+ A+ FG ID++VNNA + + + D++ V
Sbjct: 65 GGKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNV 124
Query: 123 HLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQAN--YSAAKLGL----LGLAN 176
+ RG++ ++A ++KK K I+ S + + + + Y+ AK G+ LG+A
Sbjct: 125 NTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMA- 183
Query: 177 SLAIEGRKSNIHCNTIAP 194
E K I N + P
Sbjct: 184 ----EEFKGEIAVNALWP 197
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 70.5 bits (171), Expect = 5e-12
Identities = 66/227 (29%), Positives = 98/227 (43%), Gaps = 27/227 (11%)
Query: 9 GRVVLVTGAGAGLGRAYALAFAERGALVVVNDL---GGDFKGVGKGSLAADKVVEEIRRR 65
G V ++TG +GLG A A +GA V+ DL GG+ + G+
Sbjct: 10 GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF--------- 60
Query: 66 GGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISD------EDWDII 119
A A+ S ++ + + A FGR+DV VN AGI + ED+ +
Sbjct: 61 ---APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRV 117
Query: 120 HRVHLRGSFQVTRAAWEHMKKQK------YGRIIMTSSASGIYGNFGQANYSAAKLGLLG 173
V+L G+F V R M + + G II T+S + G GQA YSA+K G++G
Sbjct: 118 LDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVG 177
Query: 174 LANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAP 220
+ +A + I TIAP T +PE + L + P
Sbjct: 178 MTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFP 224
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 68.6 bits (166), Expect = 2e-11
Identities = 53/187 (28%), Positives = 92/187 (49%), Gaps = 13/187 (6%)
Query: 10 RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKA 69
+V LVT + G+G A A A+ A VVV+ + D+ V ++ G
Sbjct: 33 KVALVTASTDGIGFAIARRLAQDRAHVVVSS---------RKQQNVDQAVATLQGEGLSV 83
Query: 70 ---VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRD-RSFARISDEDWDIIHRVHLR 125
V + E+ E++V A+ G ID++V+NA + S +++E WD ++++
Sbjct: 84 TGTVCHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVK 143
Query: 126 GSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKS 185
+T+A M+K+ G +++ SS + + G + Y+ +K LLGL N+LAIE
Sbjct: 144 APALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIELAPR 203
Query: 186 NIHCNTI 192
NI N +
Sbjct: 204 NIRVNCL 210
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 67.8 bits (164), Expect = 3e-11
Identities = 56/196 (28%), Positives = 95/196 (48%), Gaps = 19/196 (9%)
Query: 5 LRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRR 64
+ +G+V LVTGA G+GRA+A A +GA V + D + + + A D+ E +
Sbjct: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVD--WNLEAGVQCKAALDEQFEPQKT 58
Query: 65 RGGKA-VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVH 123
+ VA+ + + + +D FGR+D++VNNAG+ ++++W+ +++
Sbjct: 59 LFIQCDVADQQQLRD---TFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQIN 107
Query: 124 LRGSFQVTRAAWEHMKKQKYGR---IIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI 180
L T ++M KQ G II SS +G+ Q Y A+K G++G S A+
Sbjct: 108 LVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAL 167
Query: 181 EGR--KSNIHCNTIAP 194
S + N I P
Sbjct: 168 AANLMNSGVRLNAICP 183
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 67.4 bits (163), Expect = 5e-11
Identities = 58/220 (26%), Positives = 100/220 (45%), Gaps = 24/220 (10%)
Query: 9 GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGK 68
G +VL+TGAG G+GR FA+R +++V+ D+ +GV ++ E R+ G
Sbjct: 36 GEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINK--RGV-------EETAAECRKLGVT 86
Query: 69 A---VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLR 125
A V + + EE + + G + +VVNNAG + DE+ V++
Sbjct: 87 AHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNIL 146
Query: 126 GSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIE---- 181
G F +T+A M ++ +G I+ +S G G Y ++K +G L E
Sbjct: 147 GHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQAL 206
Query: 182 ---GRKSNIHC----NT-IAPNAGSRMTQTVMPEDLVEAL 213
G K++ C NT N +R+ + +++V +L
Sbjct: 207 GKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSL 246
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 65.9 bits (159), Expect = 1e-10
Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 15/215 (6%)
Query: 12 VLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKA-- 69
VL+TG G G+GR A FAERGA +V G+ + EEIR+ G +
Sbjct: 41 VLITGGGRGIGRQLAREFAERGARKIVL--------WGRTEKCLKETTEEIRQMGTECHY 92
Query: 70 -VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSF 128
+ + + EE + K + G I ++VNNA ++ +S D+ ++ G F
Sbjct: 93 FICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQF 152
Query: 129 QVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRK-SNI 187
T+A M + + G I+ +S + G +Y +K SL + +
Sbjct: 153 WTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGV 212
Query: 188 HCNTIAP-NAGSRMTQ--TVMPEDLVEALKPEYVA 219
T+ P + + M Q V +L LKPE VA
Sbjct: 213 SATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVA 247
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 65.9 bits (159), Expect = 1e-10
Identities = 50/195 (25%), Positives = 90/195 (46%), Gaps = 12/195 (6%)
Query: 1 MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE 60
M + R+ G+VV+VTG G G+G AF GA VV+ D + + +E
Sbjct: 1 MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICD----------KDESGGRALE 50
Query: 61 EIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAG-ILRDRSFARISDEDWDII 119
+ + + ++ + +V + FGR+D VVNNAG + S + + +
Sbjct: 51 QELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQL 110
Query: 120 HRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLA 179
++L G++ +T+ A +++K + G +I SS G G Y A K + + +LA
Sbjct: 111 LELNLLGTYTLTKLALPYLRKSQ-GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALA 169
Query: 180 IEGRKSNIHCNTIAP 194
++ + N I+P
Sbjct: 170 LDESPYGVRVNCISP 184
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 63.5 bits (153), Expect = 7e-10
Identities = 52/179 (29%), Positives = 89/179 (49%), Gaps = 17/179 (9%)
Query: 5 LRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRR 64
+ +G+V LVTGA G+GRA+A A +GA V + D + + + A D+ E +
Sbjct: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVD--WNLEAGVQCKAALDEQFEPQKT 58
Query: 65 RGGKA-VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVH 123
+ VA+ + + + +D FGR+D++VNNAG+ ++++W+ +++
Sbjct: 59 LFIQCDVADQQQLRD---TFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQIN 107
Query: 124 LRGSFQVTRAAWEHMKKQKYGR---IIMTSSASGIYGNFGQANYSAAKLGLLGLANSLA 179
L T ++M KQ G II SS +G+ Q Y A+K G++G S A
Sbjct: 108 LVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
[Homo sapiens]
Length = 252
Score = 62.0 bits (149), Expect = 2e-09
Identities = 56/186 (30%), Positives = 84/186 (45%), Gaps = 27/186 (14%)
Query: 9 GRVVLVTGAGAGLGRAYALAFAERGALVVVNDL---GGDFKGVGKGSLAADKVVEEIRRR 65
G V ++TG +GLG A A +GA V+ DL GG+ + G+
Sbjct: 10 GLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVF--------- 60
Query: 66 GGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISD------EDWDII 119
A A+ S ++ + + A FGR+DV VN AGI + ED+ +
Sbjct: 61 ---APADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRV 117
Query: 120 HRVHLRGSFQVTRAAWEHMKKQK------YGRIIMTSSASGIYGNFGQANYSAAKLGLLG 173
V+L G+F V R M + + G II T+S + G GQA YSA+K G++G
Sbjct: 118 LDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVG 177
Query: 174 LANSLA 179
+ +A
Sbjct: 178 MTLPIA 183
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 60.8 bits (146), Expect = 4e-09
Identities = 50/189 (26%), Positives = 90/189 (47%), Gaps = 14/189 (7%)
Query: 10 RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRG--- 66
RV +VTG+ +G+G A A A GA VV++ + D+ + +++ G
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISS---------RKQQNVDRAMAKLQGEGLSV 87
Query: 67 GKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILR-DRSFARISDEDWDIIHRVHLR 125
V + E+ E++V AL+ G +D +V +AG+ S S++ WD I V+++
Sbjct: 88 AGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVK 147
Query: 126 GSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKS 185
+ +M+ ++ G +I+ SS + Y+ +K LLGL +LA+E
Sbjct: 148 SPALLLSQLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPK 206
Query: 186 NIHCNTIAP 194
+I N + P
Sbjct: 207 DIRVNCVVP 215
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 60.8 bits (146), Expect = 4e-09
Identities = 50/189 (26%), Positives = 90/189 (47%), Gaps = 14/189 (7%)
Query: 10 RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRG--- 66
RV +VTG+ +G+G A A A GA VV++ + D+ + +++ G
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISS---------RKQQNVDRAMAKLQGEGLSV 87
Query: 67 GKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILR-DRSFARISDEDWDIIHRVHLR 125
V + E+ E++V AL+ G +D +V +AG+ S S++ WD I V+++
Sbjct: 88 AGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVK 147
Query: 126 GSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKS 185
+ +M+ ++ G +I+ SS + Y+ +K LLGL +LA+E
Sbjct: 148 SPALLLSQLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPK 206
Query: 186 NIHCNTIAP 194
+I N + P
Sbjct: 207 DIRVNCVVP 215
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 60.5 bits (145), Expect = 6e-09
Identities = 58/223 (26%), Positives = 95/223 (42%), Gaps = 30/223 (13%)
Query: 9 GRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGD------FKGVGKGSLAADKVVEEI 62
G +VL+TGAG G+GR A FA+ + +V+ D+ K G G+ VV+
Sbjct: 36 GEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVD-- 93
Query: 63 RRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRV 122
+N + + K VK + G + ++VNNAG++ D + V
Sbjct: 94 -------CSNREDIYSSAKKVKAEI---GDVSILVNNAGVVYTSDLFATQDPQIEKTFEV 143
Query: 123 HLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLA--- 179
++ F T+A M K +G I+ +SA+G Y ++K +G +L
Sbjct: 144 NVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDEL 203
Query: 180 ----IEGRKSNIHC----NT-IAPNAGSRMTQTVMPEDLVEAL 213
I G K+ C NT N + + T+ PE++V L
Sbjct: 204 AALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRL 246
>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
Length = 310
Score = 60.1 bits (144), Expect = 7e-09
Identities = 54/223 (24%), Positives = 100/223 (44%), Gaps = 23/223 (10%)
Query: 5 LRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRR 64
LR G+ ++TGAG G+G+AY+ A+RG VV+ + + + + EI R
Sbjct: 44 LRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVL---------ISRTLEKLEAIATEIER 94
Query: 65 RGGKAVA------NYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRD---RSFARISDED 115
G++V D + E K L+ I ++VNN G+L + F DE
Sbjct: 95 TTGRSVKIIQADFTKDDIYEHIKEKLAGLE----IGILVNNVGMLPNLLPSHFLNAPDEI 150
Query: 116 WDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLA 175
+IH ++ ++T+ +HM+ ++ G I+ SS ++ + YSA+K + +
Sbjct: 151 QSLIH-CNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFS 209
Query: 176 NSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYV 218
+L E + + + P A S + +++ E+V
Sbjct: 210 KALQEEYKAKEVIIQVLTPYAVSTAMTKYLNTNVITKTADEFV 252
>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 58.5 bits (140), Expect = 2e-08
Identities = 60/207 (28%), Positives = 92/207 (44%), Gaps = 27/207 (13%)
Query: 1 MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE 60
M +P+ +G+V +VTGA G+GR AL + GA V + G+ V +
Sbjct: 1 MAAPM--NGQVCVVTGASRGIGRGIALQLCKAGATVYI---------TGRHLDTLRVVAQ 49
Query: 61 EIRRRGGKAV-ANYDSVEEGEKVVKTALDAF-----GRIDVVVNN--AGI-----LRDRS 107
E + GG+ V DS +E E V++ + GR+DV+VNN AG+ R+++
Sbjct: 50 EAQSLGGQCVPVVCDSSQESE--VRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKA 107
Query: 108 FARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAA 167
F WD I+ V LRG + + M G I++ SS + F Y
Sbjct: 108 FWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMF-NVPYGVG 166
Query: 168 KLGLLGLANSLAIEGRKSNIHCNTIAP 194
K LA A E R+ + C ++ P
Sbjct: 167 KAACDKLAADCAHELRRHGVSCVSLWP 193
>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 58.5 bits (140), Expect = 2e-08
Identities = 60/207 (28%), Positives = 92/207 (44%), Gaps = 27/207 (13%)
Query: 1 MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVE 60
M +P+ +G+V +VTGA G+GR AL + GA V + G+ V +
Sbjct: 1 MAAPM--NGQVCVVTGASRGIGRGIALQLCKAGATVYI---------TGRHLDTLRVVAQ 49
Query: 61 EIRRRGGKAV-ANYDSVEEGEKVVKTALDAF-----GRIDVVVNN--AGI-----LRDRS 107
E + GG+ V DS +E E V++ + GR+DV+VNN AG+ R+++
Sbjct: 50 EAQSLGGQCVPVVCDSSQESE--VRSLFEQVDREQQGRLDVLVNNAYAGVQTILNTRNKA 107
Query: 108 FARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAA 167
F WD I+ V LRG + + M G I++ SS + F Y
Sbjct: 108 FWETPASMWDDINNVGLRGHYFCSVYGARLMVPAGQGLIVVISSPGSLQYMF-NVPYGVG 166
Query: 168 KLGLLGLANSLAIEGRKSNIHCNTIAP 194
K LA A E R+ + C ++ P
Sbjct: 167 KAACDKLAADCAHELRRHGVSCVSLWP 193
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 57.4 bits (137), Expect = 5e-08
Identities = 54/196 (27%), Positives = 85/196 (43%), Gaps = 24/196 (12%)
Query: 11 VVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAV 70
VV++TGA +GLG+ A F GA +V+ G+ A ++++ E+ V
Sbjct: 54 VVVITGATSGLGKECAKVFYAAGAKLVL---------CGRNGGALEELIRELTASHATKV 104
Query: 71 -------ANYDSVEEGEKVVKTA--LDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHR 121
+D + G V A L FG +D++VNNAGI I D D+ R
Sbjct: 105 QTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGI---SYRGTIMDTTVDVDKR 161
Query: 122 V---HLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSL 178
V + G +T+A M K++ G I+ SS G ++ Y+A+K + L
Sbjct: 162 VMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCL 221
Query: 179 AIEGRKSNIHCNTIAP 194
E + I I+P
Sbjct: 222 RAEMEQYEIEVTVISP 237
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,123,239
Number of Sequences: 37866
Number of extensions: 1208214
Number of successful extensions: 2550
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 2427
Number of HSP's gapped (non-prelim): 86
length of query: 736
length of database: 18,247,518
effective HSP length: 110
effective length of query: 626
effective length of database: 14,082,258
effective search space: 8815493508
effective search space used: 8815493508
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.