Search of human proteins with 4503677

Search of human proteins with 4503677

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
isoform 1 [Homo sapiens]
         (244 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503677 membrane-spanning 4-domains, subfamily A, member 2 is...   481   e-136
gi|214831008 membrane-spanning 4-domains, subfamily A, member 2 ...   355   3e-98
gi|8923206 membrane-spanning 4-domains, subfamily A, member 12 [...    73   2e-13
gi|20070328 membrane-spanning 4-domains, subfamily A, member 4 i...    72   3e-13
gi|23110995 membrane-spanning 4-domains, subfamily A, member 4 i...    72   3e-13
gi|73486649 membrane-spanning 4-domains, subfamily A, member 3 i...    71   7e-13
gi|149588599 membrane-spanning 4-domains, subfamily A, member 15...    69   4e-12
gi|119226217 membrane-spanning 4-domains, subfamily A, member 14...    69   5e-12
gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B ...    67   2e-11
gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A...    64   1e-10
gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A...    64   1e-10
gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A...    63   3e-10
gi|11139299 membrane-spanning 4-domains, subfamily A, member 7 i...    63   3e-10
gi|46249357 membrane-spanning 4-domains, subfamily A, member 7 i...    63   3e-10
gi|119226220 membrane-spanning 4-domains, subfamily A, member 14...    53   2e-07
gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A ...    53   3e-07
gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A ...    53   3e-07
gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A ...    52   6e-07
gi|22749421 membrane-spanning 4-domains, subfamily A, member 15 ...    51   1e-06
gi|23110997 membrane-spanning 4-domains, subfamily A, member 5 [...    48   9e-06
gi|167466260 membrane-spanning 4-domains, subfamily A, member 10...    47   2e-05
gi|23110987 membrane-spanning 4-domains, subfamily A, member 1 [...    45   8e-05
gi|23110989 membrane-spanning 4-domains, subfamily A, member 1 [...    45   8e-05
gi|169202868 PREDICTED: similar to membrane-spanning 4-domains, ...    44   1e-04
gi|169203526 PREDICTED: similar to membrane-spanning 4-domains, ...    44   1e-04
gi|169202217 PREDICTED: similar to membrane-spanning 4-domains, ...    44   1e-04
gi|73486653 membrane-spanning 4-domains, subfamily A, member 3 i...    38   0.009
gi|46249347 membrane-spanning 4-domains, subfamily A, member 7 i...    36   0.035
gi|46249359 membrane-spanning 4-domains, subfamily A, member 7 i...    36   0.035
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap...    34   0.13 

>gi|4503677 membrane-spanning 4-domains, subfamily A, member 2
           isoform 1 [Homo sapiens]
          Length = 244

 Score =  481 bits (1238), Expect = e-136
 Identities = 244/244 (100%), Positives = 244/244 (100%)

Query: 1   MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF 60
           MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF
Sbjct: 1   MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF 60

Query: 61  LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISER 120
           LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISER
Sbjct: 61  LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISER 120

Query: 121 RNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTE 180
           RNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTE
Sbjct: 121 RNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTE 180

Query: 181 IVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSP 240
           IVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSP
Sbjct: 181 IVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSP 240

Query: 241 PIDL 244
           PIDL
Sbjct: 241 PIDL 244


>gi|214831008 membrane-spanning 4-domains, subfamily A, member 2
           isoform 2 [Homo sapiens]
          Length = 195

 Score =  355 bits (910), Expect = 3e-98
 Identities = 179/179 (100%), Positives = 179/179 (100%)

Query: 1   MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF 60
           MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF
Sbjct: 1   MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF 60

Query: 61  LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISER 120
           LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISER
Sbjct: 61  LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISER 120

Query: 121 RNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFST 179
           RNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFST
Sbjct: 121 RNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFST 179


>gi|8923206 membrane-spanning 4-domains, subfamily A, member 12
           [Homo sapiens]
          Length = 267

 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 1/110 (0%)

Query: 44  SPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSV-LDISHIEGDIFSSFKAGYPF 102
           +P + T +   K+E + LGV QI+  ++ + FG V+C +      + G   ++   GYPF
Sbjct: 74  NPSVGTAVMNFKEEAKALGVIQIMVGLMHIGFGIVLCLISFSFREVLGFASTAVIGGYPF 133

Query: 103 WGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINL 152
           WG + F ISG LS+ + +  +  LV+GSLG N  SSI    G+ +L++++
Sbjct: 134 WGGLSFIISGSLSVSASKELSRCLVKGSLGMNIVSSILAFIGVILLLVDM 183


>gi|20070328 membrane-spanning 4-domains, subfamily A, member 4
           isoform a [Homo sapiens]
          Length = 220

 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 58/155 (37%), Positives = 79/155 (50%), Gaps = 12/155 (7%)

Query: 54  LKKEQEFLGVTQILTAMICLCFG-TVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISG 112
           LK E + LGV QILTA++ L  G T++C     S+  G    S   GY  WG++ F ISG
Sbjct: 40  LKGEPKVLGVVQILTALMSLSMGITMMCMA---SNTYGSNPISVYIGYTIWGSVMFIISG 96

Query: 113 MLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHS--CQKFFET 170
            LSI +  R    LVRGSLG N  SS+   +GI I       SLA+   H   C  +  +
Sbjct: 97  SLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTF----SLAFYSFHHPYCNYYGNS 152

Query: 171 KCFMASFSTEIVV--MMLFLTILGLGSAVSLTICG 203
                + S  + +  M+L L++L    AVSL+  G
Sbjct: 153 NNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFG 187


>gi|23110995 membrane-spanning 4-domains, subfamily A, member 4
           isoform b [Homo sapiens]
          Length = 239

 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 58/155 (37%), Positives = 79/155 (50%), Gaps = 12/155 (7%)

Query: 54  LKKEQEFLGVTQILTAMICLCFG-TVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISG 112
           LK E + LGV QILTA++ L  G T++C     S+  G    S   GY  WG++ F ISG
Sbjct: 59  LKGEPKVLGVVQILTALMSLSMGITMMCMA---SNTYGSNPISVYIGYTIWGSVMFIISG 115

Query: 113 MLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHS--CQKFFET 170
            LSI +  R    LVRGSLG N  SS+   +GI I       SLA+   H   C  +  +
Sbjct: 116 SLSIAAGIRTTKGLVRGSLGMNITSSVLAASGILINTF----SLAFYSFHHPYCNYYGNS 171

Query: 171 KCFMASFSTEIVV--MMLFLTILGLGSAVSLTICG 203
                + S  + +  M+L L++L    AVSL+  G
Sbjct: 172 NNCHGTMSILMGLDGMVLLLSVLEFCIAVSLSAFG 206


>gi|73486649 membrane-spanning 4-domains, subfamily A, member 3
           isoform a [Homo sapiens]
          Length = 214

 Score = 71.2 bits (173), Expect = 7e-13
 Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 8/174 (4%)

Query: 27  EISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDIS 86
           E  P+E+++        SP         K + + LG  QIL A + L  G  + S+    
Sbjct: 23  EAGPEELNTSVYQPIDGSPDYQ------KAKLQVLGAIQILNAAMILALGVFLGSLQYPY 76

Query: 87  HIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGI 145
           H +   F  +F  GYP WGA+FF  SG LS+++  +     ++ S G N AS+     G 
Sbjct: 77  HFQKHFFFFTFYTGYPIWGAVFFCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGT 136

Query: 146 TILIINLKKSLAYIH-IHSCQKFFETKCFMASFSTEIVVMMLFLTILGLGSAVS 198
             L +N+  ++  +   HS  +  +   +M S S  +V ++L LT+L L   +S
Sbjct: 137 AFLSLNIAVNIQSLRSCHSSSESPDLCNYMGSISNGMVSLLLILTLLELCVTIS 190


>gi|149588599 membrane-spanning 4-domains, subfamily A, member 15
           isoform 1 [Homo sapiens]
          Length = 240

 Score = 68.9 bits (167), Expect = 4e-12
 Identities = 50/143 (34%), Positives = 68/143 (47%), Gaps = 15/143 (10%)

Query: 13  LPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMIC 72
           LP      P     E  P    + R  +     P+ T+LT    E + LG  QIL  +I 
Sbjct: 29  LPTSMCQPPGIMQFEEPPLGAQTPRATQPPDLRPVETFLT---GEPKVLGTVQILIGLIH 85

Query: 73  LCFGTVVCSV----LDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVR 128
           L FG+V+  V    + I  IEG        G PFWG   F ISG LS+ +E+ + + LVR
Sbjct: 86  LGFGSVLLMVRRGHVGIFFIEG--------GVPFWGGACFIISGSLSVAAEKNHTSCLVR 137

Query: 129 GSLGANTASSIAGGTGITILIIN 151
            SLG N  S +A   G  IL+++
Sbjct: 138 SSLGTNILSVMAAFAGTAILLMD 160


>gi|119226217 membrane-spanning 4-domains, subfamily A, member 14
           isoform 1 [Homo sapiens]
          Length = 679

 Score = 68.6 bits (166), Expect = 5e-12
 Identities = 53/167 (31%), Positives = 80/167 (47%), Gaps = 15/167 (8%)

Query: 22  AFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCS 81
           A  V+ I P E     +L +    P  + L  LK E   LG TQIL A+I + FGT+   
Sbjct: 10  ATHVITIKPNET----VLTAFPYRPHSSLLDFLKGEPRVLGATQILLALIIVGFGTIFA- 64

Query: 82  VLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAG 141
            L+       +      GYPFWGA+ F ++G L++  ++  +  L +G  G N  SS+  
Sbjct: 65  -LNYIGFSQRLPLVVLTGYPFWGALIFILTGYLTVTDKK--SKLLGQGVTGMNVISSLVA 121

Query: 142 GTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFL 188
            TGIT  I++ +    Y  + S    FE  C    FS  + +++ FL
Sbjct: 122 ITGITFTILSYRHQDKYCQMPS----FEEICV---FSRTLFIVLFFL 161


>gi|13899295 membrane-spanning 4-domains, subfamily A, member 8B
           [Homo sapiens]
          Length = 250

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 16/142 (11%)

Query: 13  LPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMIC 72
           +P  P+S P   ++  +P       L+ + +  P+   L    KE + LG  QI+  +  
Sbjct: 33  VPLYPNSQPQVHLVPGNPPS-----LVSNVNGQPVQKAL----KEGKTLGAIQIIIGLAH 83

Query: 73  LCFGTVVCSVLDISHIEGDIFS-SFKAGYPFWGAIFFSISGMLSIISERRNATY-LVRGS 130
           +  G+++ +VL      G+  S SF  G+PFWG ++F ISG LS+ +E +  +Y L+ GS
Sbjct: 84  IGLGSIMATVL-----VGEYLSISFYGGFPFWGGLWFIISGSLSVAAENQPYSYCLLSGS 138

Query: 131 LGANTASSIAGGTGITILIINL 152
           LG N  S+I    G+ + I +L
Sbjct: 139 LGLNIVSAICSAVGVILFITDL 160


>gi|239755562 PREDICTED: membrane-spanning 4-domains, subfamily A,
           member 4E isoform 1 [Homo sapiens]
          Length = 243

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 51/151 (33%), Positives = 74/151 (49%), Gaps = 6/151 (3%)

Query: 55  KKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGML 114
           K++ + LGV +IL A++ L  G ++  V   S+ E  IF      Y  WG++ F IS  L
Sbjct: 64  KRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIF--VYVAYTIWGSVMFIISVSL 121

Query: 115 SIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSC-QKFFETKCF 173
           S+ +  R    LV GSLG N  SS+   +GI I  I+L  +      H C      + C+
Sbjct: 122 SVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISL--TFYSFRYHYCNHDQLSSNCY 179

Query: 174 MA-SFSTEIVVMMLFLTILGLGSAVSLTICG 203
           M  S       M+L L++L    AVSL+  G
Sbjct: 180 MTMSILMGTDGMVLLLSVLEFCIAVSLSAFG 210


>gi|239750062 PREDICTED: membrane-spanning 4-domains, subfamily A,
           member 4E isoform 3 [Homo sapiens]
          Length = 243

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 51/151 (33%), Positives = 74/151 (49%), Gaps = 6/151 (3%)

Query: 55  KKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGML 114
           K++ + LGV +IL A++ L  G ++  V   S+ E  IF      Y  WG++ F IS  L
Sbjct: 64  KRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIF--VYVAYTIWGSVMFIISVSL 121

Query: 115 SIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSC-QKFFETKCF 173
           S+ +  R    LV GSLG N  SS+   +GI I  I+L  +      H C      + C+
Sbjct: 122 SVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISL--TFYSFRYHYCNHDQLSSNCY 179

Query: 174 MA-SFSTEIVVMMLFLTILGLGSAVSLTICG 203
           M  S       M+L L++L    AVSL+  G
Sbjct: 180 MTMSILMGTDGMVLLLSVLEFCIAVSLSAFG 210


>gi|239744375 PREDICTED: membrane-spanning 4-domains, subfamily A,
           member 4E isoform 3 [Homo sapiens]
          Length = 243

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 50/151 (33%), Positives = 74/151 (49%), Gaps = 6/151 (3%)

Query: 55  KKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGML 114
           K++ + LGV +IL A++ L  G ++  V   S+ E  IF      Y  WG++ F IS  L
Sbjct: 64  KRKPKVLGVVRILIALMSLSMGIIMMCVAFSSYEEHPIF--VYVAYTIWGSVMFIISVSL 121

Query: 115 SIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSC-QKFFETKCF 173
           S+ +  R    LV GSLG N  SS+   +GI I  I+L  +      H C      + C+
Sbjct: 122 SVAAGIRTTKGLVGGSLGKNITSSVLAISGILINAISL--TFYSFRYHYCNHDQLSSNCY 179

Query: 174 MA-SFSTEIVVMMLFLTILGLGSAVSLTICG 203
           M  S       M+L L++L    AV+L+  G
Sbjct: 180 MTMSILMGTDGMVLLLSVLEFCIAVALSAFG 210


>gi|11139299 membrane-spanning 4-domains, subfamily A, member 7
           isoform 1 [Homo sapiens]
          Length = 240

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 48/158 (30%), Positives = 73/158 (46%), Gaps = 20/158 (12%)

Query: 54  LKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGM 113
           L  E   LG  QIL  ++    G ++      SH    I ++  +GYPF GA+ F I+G 
Sbjct: 41  LPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGS 100

Query: 114 LSIISERRNATYLVRGSLGANTASSIAGGTGITILI----------------INLKKSLA 157
           LSIIS +++       SL +N  SS+  G G+ +L                 ++   SL 
Sbjct: 101 LSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLP 160

Query: 158 YIHIHSCQKFFETK-CFMASFS-TEIVVMMLFLTILGL 193
           Y   +     +E K C + S S T ++V+ML  T+L L
Sbjct: 161 YSEYY--YPIYEIKDCLLTSVSLTGVLVVMLIFTVLEL 196


>gi|46249357 membrane-spanning 4-domains, subfamily A, member 7
           isoform 1 [Homo sapiens]
          Length = 240

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 48/158 (30%), Positives = 73/158 (46%), Gaps = 20/158 (12%)

Query: 54  LKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGM 113
           L  E   LG  QIL  ++    G ++      SH    I ++  +GYPF GA+ F I+G 
Sbjct: 41  LPTETTVLGTVQILCCLLISSLGAILVFAPYPSHFNPAISTTLMSGYPFLGALCFGITGS 100

Query: 114 LSIISERRNATYLVRGSLGANTASSIAGGTGITILI----------------INLKKSLA 157
           LSIIS +++       SL +N  SS+  G G+ +L                 ++   SL 
Sbjct: 101 LSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMDYLSSLP 160

Query: 158 YIHIHSCQKFFETK-CFMASFS-TEIVVMMLFLTILGL 193
           Y   +     +E K C + S S T ++V+ML  T+L L
Sbjct: 161 YSEYY--YPIYEIKDCLLTSVSLTGVLVVMLIFTVLEL 196


>gi|119226220 membrane-spanning 4-domains, subfamily A, member 14
           isoform 2 [Homo sapiens]
          Length = 662

 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 49/167 (29%), Positives = 70/167 (41%), Gaps = 32/167 (19%)

Query: 22  AFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCS 81
           A  V+ I P E     +L +    P  + L  LK E   LG TQIL A+I + FGT+   
Sbjct: 10  ATHVITIKPNET----VLTAFPYRPHSSLLDFLKGEPRVLGATQILLALIIVGFGTIF-- 63

Query: 82  VLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAG 141
            L+       +      GYPFWGA+                   + +G  G N  SS+  
Sbjct: 64  ALNYIGFSQRLPLVVLTGYPFWGAL-------------------IGQGVTGMNVISSLVA 104

Query: 142 GTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFL 188
            TGIT  I++ +    Y  + S    FE  C    FS  + +++ FL
Sbjct: 105 ITGITFTILSYRHQDKYCQMPS----FEEICV---FSRTLFIVLFFL 144


>gi|23238234 membrane-spanning 4-domains, subfamily A, member 6A
           isoform 2 [Homo sapiens]
          Length = 225

 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 44/161 (27%), Positives = 67/161 (41%), Gaps = 17/161 (10%)

Query: 54  LKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGM 113
           L  E + +G  QIL  M+ L  G ++ S     +      +   + YPF G  FF ISG 
Sbjct: 41  LHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGS 100

Query: 114 LSIISERRNATYLVRGSLGANTASSIAGGTGITILII----------------NLKKSLA 157
           LSI +E+R    LV  SL  +  S+++   G  IL +                N   + +
Sbjct: 101 LSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRS 160

Query: 158 YIHIHSCQKFFETKCFMASFS-TEIVVMMLFLTILGLGSAV 197
           Y+        + T C+ A  S    + +ML  T+L    AV
Sbjct: 161 YVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAV 201


>gi|23238238 membrane-spanning 4-domains, subfamily A, member 6A
           isoform 1 [Homo sapiens]
          Length = 248

 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 44/161 (27%), Positives = 67/161 (41%), Gaps = 17/161 (10%)

Query: 54  LKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGM 113
           L  E + +G  QIL  M+ L  G ++ S     +      +   + YPF G  FF ISG 
Sbjct: 41  LHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGS 100

Query: 114 LSIISERRNATYLVRGSLGANTASSIAGGTGITILII----------------NLKKSLA 157
           LSI +E+R    LV  SL  +  S+++   G  IL +                N   + +
Sbjct: 101 LSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRS 160

Query: 158 YIHIHSCQKFFETKCFMASFS-TEIVVMMLFLTILGLGSAV 197
           Y+        + T C+ A  S    + +ML  T+L    AV
Sbjct: 161 YVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAV 201


>gi|23238236 membrane-spanning 4-domains, subfamily A, member 6A
           isoform 3 [Homo sapiens]
          Length = 178

 Score = 51.6 bits (122), Expect = 6e-07
 Identities = 32/97 (32%), Positives = 47/97 (48%)

Query: 54  LKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGM 113
           L  E + +G  QIL  M+ L  G ++ S     +      +   + YPF G  FF ISG 
Sbjct: 41  LHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGS 100

Query: 114 LSIISERRNATYLVRGSLGANTASSIAGGTGITILII 150
           LSI +E+R    LV  SL  +  S+++   G  IL +
Sbjct: 101 LSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSV 137


>gi|22749421 membrane-spanning 4-domains, subfamily A, member 15
           isoform 2 [Homo sapiens]
          Length = 147

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 24/55 (43%), Positives = 34/55 (61%)

Query: 97  KAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIIN 151
           + G PFWG   F ISG LS+ +E+ + + LVR SLG N  S +A   G  IL+++
Sbjct: 13  EGGVPFWGGACFIISGSLSVAAEKNHTSCLVRSSLGTNILSVMAAFAGTAILLMD 67


>gi|23110997 membrane-spanning 4-domains, subfamily A, member 5
           [Homo sapiens]
          Length = 200

 Score = 47.8 bits (112), Expect = 9e-06
 Identities = 48/194 (24%), Positives = 81/194 (41%), Gaps = 8/194 (4%)

Query: 18  SSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKK----EQEFLGVTQILTAMICL 73
           SS     V  + P E+++     +  S    +  + L+K    + + LG  QIL  ++  
Sbjct: 3   SSTAHSPVFLVFPPEITASEYESTELSATTFSTQSPLQKLFARKMKILGTIQILFGIMTF 62

Query: 74  CFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGA 133
            FG +    L   +        F +GYPFWG++ F  SG   I  +R+    L+  S   
Sbjct: 63  SFGVIFLFTLLKPYPRFPFI--FLSGYPFWGSVLFINSGAFLIAVKRKTTETLIILSRIM 120

Query: 134 NTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTEIVVMMLFLTILGL 193
           N  S++    GI +L         YI  +S Q   + K     F   ++ +M F +I+ L
Sbjct: 121 NFLSALGAIAGIILLTFGFILDQNYICGYSHQN-SQCKAVTVLFLGILITLMTF-SIIEL 178

Query: 194 GSAVSLTICGAGEE 207
             ++  +I G   E
Sbjct: 179 FISLPFSILGCHSE 192


>gi|167466260 membrane-spanning 4-domains, subfamily A, member 10
           [Homo sapiens]
          Length = 267

 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 35/120 (29%), Positives = 56/120 (46%), Gaps = 9/120 (7%)

Query: 29  SPQEVSSGRLLKSASSPPLHTWLTVLKKEQEFLGVTQILTAMICLCFGTVVCSVLDISHI 88
           +PQ  +  +LL            ++LK+    LG   I  A++ L FG  + S++   H+
Sbjct: 32  APQNTTQPKLLAPHQHEKSQKKSSLLKE----LGAFHITIALLHLVFGGYLASIVKNLHL 87

Query: 89  EGDIFSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITIL 148
                   K+ YPFWGA  F ISG+L+I  +  + TYL    L  N  S     +G+ ++
Sbjct: 88  V-----VLKSWYPFWGAASFLISGILAITMKTFSKTYLKMLCLMTNLISLFCVLSGLFVI 142


>gi|23110987 membrane-spanning 4-domains, subfamily A, member 1
           [Homo sapiens]
          Length = 297

 Score = 44.7 bits (104), Expect = 8e-05
 Identities = 45/191 (23%), Positives = 78/191 (40%), Gaps = 34/191 (17%)

Query: 30  PQEVSSGRLLKSASSPPLHTWLTVL--------KKEQEFLGVTQILTAMICLCFGTVVCS 81
           P E   G +   +   PL   ++ L         +E + LG  QI+  +  +  G ++  
Sbjct: 13  PAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLM- 71

Query: 82  VLDISHIEGDIFSSF--KAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSI 139
                 I   I++       YP WG I + ISG L   +E+ +   LV+G +  N+ S  
Sbjct: 72  ------IPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLF 125

Query: 140 AGGTGITIL---IINLKKS--------------LAYIHIHSCQKFFETKCFMASFSTEIV 182
           A  +G+ +    I+N+K S                YI+I++C+    ++    S      
Sbjct: 126 AAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYS 185

Query: 183 VMMLFLTILGL 193
           +  LFL IL +
Sbjct: 186 IQSLFLGILSV 196


>gi|23110989 membrane-spanning 4-domains, subfamily A, member 1
           [Homo sapiens]
          Length = 297

 Score = 44.7 bits (104), Expect = 8e-05
 Identities = 45/191 (23%), Positives = 78/191 (40%), Gaps = 34/191 (17%)

Query: 30  PQEVSSGRLLKSASSPPLHTWLTVL--------KKEQEFLGVTQILTAMICLCFGTVVCS 81
           P E   G +   +   PL   ++ L         +E + LG  QI+  +  +  G ++  
Sbjct: 13  PAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLM- 71

Query: 82  VLDISHIEGDIFSSF--KAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSI 139
                 I   I++       YP WG I + ISG L   +E+ +   LV+G +  N+ S  
Sbjct: 72  ------IPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLF 125

Query: 140 AGGTGITIL---IINLKKS--------------LAYIHIHSCQKFFETKCFMASFSTEIV 182
           A  +G+ +    I+N+K S                YI+I++C+    ++    S      
Sbjct: 126 AAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYS 185

Query: 183 VMMLFLTILGL 193
           +  LFL IL +
Sbjct: 186 IQSLFLGILSV 196


>gi|169202868 PREDICTED: similar to membrane-spanning 4-domains,
           subfamily A, member 8B [Homo sapiens]
          Length = 391

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 23/71 (32%), Positives = 41/71 (57%), Gaps = 2/71 (2%)

Query: 93  FSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINL 152
           F ++ +GYP WG + + +SG LS+ + +  +  +V  S+  N  S++    GI I+I +L
Sbjct: 174 FVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIIITDL 233

Query: 153 KKSLAYIHIHS 163
             SL Y+  +S
Sbjct: 234 --SLYYVTTYS 242


>gi|169203526 PREDICTED: similar to membrane-spanning 4-domains,
           subfamily A, member 8B [Homo sapiens]
          Length = 391

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 23/71 (32%), Positives = 41/71 (57%), Gaps = 2/71 (2%)

Query: 93  FSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINL 152
           F ++ +GYP WG + + +SG LS+ + +  +  +V  S+  N  S++    GI I+I +L
Sbjct: 174 FVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIIITDL 233

Query: 153 KKSLAYIHIHS 163
             SL Y+  +S
Sbjct: 234 --SLYYVTTYS 242


>gi|169202217 PREDICTED: similar to membrane-spanning 4-domains,
           subfamily A, member 8B [Homo sapiens]
          Length = 391

 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 23/71 (32%), Positives = 41/71 (57%), Gaps = 2/71 (2%)

Query: 93  FSSFKAGYPFWGAIFFSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINL 152
           F ++ +GYP WG + + +SG LS+ + +  +  +V  S+  N  S++    GI I+I +L
Sbjct: 174 FVTWLSGYPLWGGLSYIVSGSLSVWAAKDPSPCVVNSSISFNIISALFAFAGIFIIITDL 233

Query: 153 KKSLAYIHIHS 163
             SL Y+  +S
Sbjct: 234 --SLYYVTTYS 242


>gi|73486653 membrane-spanning 4-domains, subfamily A, member 3
           isoform b [Homo sapiens]
          Length = 168

 Score = 37.7 bits (86), Expect = 0.009
 Identities = 25/92 (27%), Positives = 45/92 (48%), Gaps = 1/92 (1%)

Query: 108 FSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIH-IHSCQK 166
           F  SG LS+++  +     ++ S G N AS+     G   L +N+  ++  +   HS  +
Sbjct: 53  FCSSGTLSVVAGIKPTRTWIQNSFGMNIASATIALVGTAFLSLNIAVNIQSLRSCHSSSE 112

Query: 167 FFETKCFMASFSTEIVVMMLFLTILGLGSAVS 198
             +   +M S S  +V ++L LT+L L   +S
Sbjct: 113 SPDLCNYMGSISNGMVSLLLILTLLELCVTIS 144


>gi|46249347 membrane-spanning 4-domains, subfamily A, member 7
           isoform 2 [Homo sapiens]
          Length = 195

 Score = 35.8 bits (81), Expect = 0.035
 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 20/104 (19%)

Query: 108 FSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILI----------------IN 151
           F I+G LSIIS +++       SL +N  SS+  G G+ +L                 ++
Sbjct: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109

Query: 152 LKKSLAYIHIHSCQKFFETK-CFMASFS-TEIVVMMLFLTILGL 193
              SL Y   +     +E K C + S S T ++V+ML  T+L L
Sbjct: 110 YLSSLPYSEYY--YPIYEIKDCLLTSVSLTGVLVVMLIFTVLEL 151


>gi|46249359 membrane-spanning 4-domains, subfamily A, member 7
           isoform 2 [Homo sapiens]
          Length = 195

 Score = 35.8 bits (81), Expect = 0.035
 Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 20/104 (19%)

Query: 108 FSISGMLSIISERRNATYLVRGSLGANTASSIAGGTGITILI----------------IN 151
           F I+G LSIIS +++       SL +N  SS+  G G+ +L                 ++
Sbjct: 50  FGITGSLSIISGKQSTKPFDLSSLTSNAVSSVTAGAGLFLLADSMVALRTASQHCGSEMD 109

Query: 152 LKKSLAYIHIHSCQKFFETK-CFMASFS-TEIVVMMLFLTILGL 193
              SL Y   +     +E K C + S S T ++V+ML  T+L L
Sbjct: 110 YLSSLPYSEYY--YPIYEIKDCLLTSVSLTGVLVVMLIFTVLEL 151


>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
           sapiens]
          Length = 839

 Score = 33.9 bits (76), Expect = 0.13
 Identities = 23/84 (27%), Positives = 38/84 (45%), Gaps = 10/84 (11%)

Query: 159 IHIHSCQKFFETKCFMASFSTEIV-----VMMLFLTILGLGSAVSLTICGAGEELKGNKV 213
           + ++ C+    T+C   S ST ++     ++ + L I  L S +   +CG     KG + 
Sbjct: 664 LRVNLCECTHPTQCRATSRSTGVILGKWAILAILLGIALLFSVLLTLVCGVFGATKGKRF 723

Query: 214 PEDRVYEELNIYSATYSELEDPGE 237
           PED   + L I     S  E PG+
Sbjct: 724 PEDLAQQNLII-----SNTEAPGD 742


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,063,122
Number of Sequences: 37866
Number of extensions: 363068
Number of successful extensions: 944
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 902
Number of HSP's gapped (non-prelim): 40
length of query: 244
length of database: 18,247,518
effective HSP length: 99
effective length of query: 145
effective length of database: 14,498,784
effective search space: 2102323680
effective search space used: 2102323680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.