Search of human proteins with 4503199

Search of human proteins with 4503199

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide
1 [Homo sapiens]
         (512 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...  1041   0.0  
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   762   0.0  
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   367   e-101
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   271   1e-72
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   253   2e-67
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  249   5e-66
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   247   2e-65
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   243   2e-64
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   242   7e-64
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   241   1e-63
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   239   4e-63
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   239   4e-63
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   237   2e-62
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   234   1e-61
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   233   3e-61
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   228   1e-59
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   226   4e-59
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   216   5e-56
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   209   5e-54
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   207   2e-53
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   206   3e-53
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   195   7e-50
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   188   1e-47
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   183   4e-46
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   155   6e-38
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   105   1e-22
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   104   2e-22
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   104   2e-22
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   103   5e-22
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   102   6e-22

>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score = 1041 bits (2693), Expect = 0.0
 Identities = 512/512 (100%), Positives = 512/512 (100%)

Query: 1   MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 60
           MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH
Sbjct: 1   MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 60

Query: 61  LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 120
           LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
Sbjct: 61  LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 120

Query: 121 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 180
           MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
Sbjct: 121 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 180

Query: 181 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 240
           PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
Sbjct: 181 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 240

Query: 241 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV 300
           RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV
Sbjct: 241 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANV 300

Query: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360
           QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS
Sbjct: 301 QLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLS 360

Query: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420
           DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL
Sbjct: 361 DRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKL 420

Query: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480
           WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF
Sbjct: 421 WVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480

Query: 481 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 512
           SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
Sbjct: 481 SVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS 512


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  762 bits (1967), Expect = 0.0
 Identities = 371/508 (73%), Positives = 430/508 (84%), Gaps = 3/508 (0%)

Query: 5   ISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALS 64
           +  SATE LLAS IFCLVFWV++  RP+VPKGLK+PP PWGWPL+GH+LTLGKNPHLALS
Sbjct: 7   VPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALS 66

Query: 65  RMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFS 124
           RMSQ+YGDVLQIRIGSTPV+VLS LDTIRQALVRQGDDFKGRPDLYT TLI++GQS++FS
Sbjct: 67  RMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFS 126

Query: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF 184
            DSGPVWAARRRLAQN L +FSIASDPASS+SCYLEEHVSKEA+ LIS LQELMAGPGHF
Sbjct: 127 TDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHF 186

Query: 185 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLP 244
           +PY  VVVSV NVI A+CFG+ +  +  E+LSLV   + F E   SGNP DF PILRYLP
Sbjct: 187 DPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLP 246

Query: 245 NPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSD 304
           NP+L  FK  N++F  F+QK V+EHY+ F+K  +RDIT +L +H   K+    +   +  
Sbjct: 247 NPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKH--SKKGPRASGNLIPQ 304

Query: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364
           EKI+N+V D+FGAGFDTVTTAISWSLMYLV  P +QRKIQ+ELDTVIGR RRPRLSDR  
Sbjct: 305 EKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQ 364

Query: 365 LPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 424
           LPY+EAFILETFRHSSF+PFTIPHSTTRDT+L GFYIPK  CVFVNQWQ+NHD +LW +P
Sbjct: 365 LPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDP 424

Query: 425 SEFLPERFLTPDG-AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483
           SEF PERFLT DG AI+K LSEK+++FGMGKR+CIGE +A+WE+FLFLAILLQ++EFSVP
Sbjct: 425 SEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVP 484

Query: 484 LGVKVDMTPIYGLTMKHACCEHFQMQLR 511
            GVKVD+TPIYGLTMKHA CEH Q +LR
Sbjct: 485 PGVKVDLTPIYGLTMKHARCEHVQARLR 512


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  367 bits (941), Expect = e-101
 Identities = 202/504 (40%), Positives = 294/504 (58%), Gaps = 10/504 (1%)

Query: 2   LFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHL 61
           L P+S+  T  LL   +   V    R  R +  +    PPGP+ WPLIG+   +G+  HL
Sbjct: 13  LNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHL 72

Query: 62  ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSM 121
           + +R++++YGDV QIR+GS P+VVL+G   I QALV+QG  F  RP   +F ++S G+SM
Sbjct: 73  SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSM 132

Query: 122 SFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGP 181
           +F   S   W  +RR A + +++F     P S     LE HV  EA  L++ L    A  
Sbjct: 133 AFGHYSEH-WKVQRRAAHSMMRNF-FTRQPRSRQ--VLEGHVLSEARELVALLVRGSADG 188

Query: 182 GHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILR 241
              +P    VV+V NV+ A+CFG RY H+  E   L++ N  FG  VG+G+  D +P L+
Sbjct: 189 AFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQ 248

Query: 242 YLPNPSLNAFKD---LNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLDEN 297
           Y PNP    F++   LN  F +F+      H ++   G   RD+ D+ I   ++K   ++
Sbjct: 249 YFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDS 308

Query: 298 --ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355
                +L  E +   + D+FGA  DT++TA+ W L+     P VQ ++Q ELD V+GR R
Sbjct: 309 HGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDR 368

Query: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415
            P + D+ +LPY+ AF+ E  R SSFVP TIPH+TT +TS+ G++IPK   VFVNQW +N
Sbjct: 369 LPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVN 428

Query: 416 HDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILL 475
           HD   W NP  F P RFL  DG I+K L+ +V+IF +GKR+CIGE +++ ++FLF++IL 
Sbjct: 429 HDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILA 488

Query: 476 QRVEFSVPLGVKVDMTPIYGLTMK 499
            + +F         M   YGLT+K
Sbjct: 489 HQCDFRANPNEPAKMNFSYGLTIK 512


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  271 bits (693), Expect = 1e-72
 Identities = 154/488 (31%), Positives = 264/488 (54%), Gaps = 44/488 (9%)

Query: 40  PPGPWGWPLI---GHML-----------------------TLGKNPHLALSRMSQQYGDV 73
           PPGP  WPL+   GH+L                        +G  P + L+ +++ YG +
Sbjct: 60  PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIG--PQVLLAHLARVYGSI 117

Query: 74  LQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAA 133
               IG   VVVLS   ++R+ALV+Q + F  RP +   ++++  + + F+   GPVW  
Sbjct: 118 FSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFA-HYGPVWRQ 176

Query: 134 RRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVS 193
           +R+ + + L+ F +           LE  + +E + + + +Q+   G   F P+  +  +
Sbjct: 177 QRKFSHSTLRHFGLG-------KLSLEPKIIEEFKYVKAEMQK--HGEDPFCPFSIISNA 227

Query: 194 VTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNP--ADFIPILRYLPNPSLNAF 251
           V+N+IC++CFG+R+D+ + E   ++   +   E+  +      +  P L YLP       
Sbjct: 228 VSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKEL 287

Query: 252 KDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIV 311
           + + +   SF++K++K+H ++ ++ + +D  D  + H +E++   N+N    +E +  I+
Sbjct: 288 RQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEER-KNNSNSSFDEEYLFYII 346

Query: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 371
            DLF AG DT T ++ W L+Y+ +NP VQ K+ EE++ VIG +R P L+D++ +PY EA 
Sbjct: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEAT 406

Query: 372 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPER 431
           I+E  R +  VP  IPH T+ +T L+G+ IPKG  +  N W ++ D  +W  P +F P R
Sbjct: 407 IMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNR 466

Query: 432 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVD-M 490
           FL   G + K   E  I FG+GKR C+GE +A+ E+FL    L+Q   F++P   K   +
Sbjct: 467 FLDDQGQLIK--KETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLL 524

Query: 491 TPIYGLTM 498
           T  +GLT+
Sbjct: 525 TGRFGLTL 532


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  253 bits (647), Expect = 2e-67
 Identities = 157/491 (31%), Positives = 260/491 (52%), Gaps = 21/491 (4%)

Query: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSR 65
           M A+  LL +++ CL   V+ +   Q     K PPGP   P IG+ L L  +  + +L +
Sbjct: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 66  MSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSP 125
           +S++YG V  I +G   VVVL G D +++ALV Q ++F GR +  TF  +  G  ++FS 
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFS- 119

Query: 126 DSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFN 185
            +G      RR +   L+ F +           +EE + +EA  LI  L+       + +
Sbjct: 120 -NGERAKQLRRFSIATLRGFGVGKRG-------IEERIQEEAGFLIDALRGTHGA--NID 169

Query: 186 PYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRY 242
           P  ++  +V+NVI +I FG R+D+  +E LSL+ +     +   +        F  ++++
Sbjct: 170 PTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKH 229

Query: 243 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQL 302
           LP P   AFK+L +    F+ K V+ + +T +    RD  DS +   QE++  +N N + 
Sbjct: 230 LPGPQQQAFKEL-QGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEE--KNPNTEF 286

Query: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362
             + ++   L+LF AG +TV+T + +  + L+ +P V+ K+ EE+D VIG++R+P+  DR
Sbjct: 287 YLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR 346

Query: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422
           + +PY EA I E  R    +P  + H   +DT  + F++PKG  VF     +  D + + 
Sbjct: 347 AKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFS 406

Query: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482
           NP +F P+ FL   G   K  S+  + F +GKR C GE +AR E+FLF   ++Q   F  
Sbjct: 407 NPRDFNPQHFLDKKGQFKK--SDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKS 464

Query: 483 PLGVK-VDMTP 492
           P   K +D++P
Sbjct: 465 PQSPKDIDVSP 475


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  249 bits (635), Expect = 5e-66
 Identities = 152/459 (33%), Positives = 241/459 (52%), Gaps = 25/459 (5%)

Query: 36  GLKNPPGPWGWPLIGHMLTLGKNPHLALS--RMSQQYGDVLQIRIGSTPVVVLSGLDTIR 93
           G K P      PL+G +  L ++ H+  +  ++ ++YG +  +R+G+   V++      +
Sbjct: 24  GAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAK 83

Query: 94  QALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPAS 153
           + L+++G DF GRP + T  + SN +      DSG  W   RRLA   + +F++  D   
Sbjct: 84  EVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLA---MATFALFKDGDQ 140

Query: 154 STSCYLEEHVSKEAEVLISTLQELMAGP-GHFNPYRY-VVVSVTNVICAICFGRRYDHNH 211
                LE+ + +E    ISTL +++A   G      + V V+VTNVI  ICF   Y +  
Sbjct: 141 K----LEKIICQE----ISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGD 192

Query: 212 QELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 271
            EL  + N N    + +   +  D +P L+  PN +L   K   +     + K+++ + +
Sbjct: 193 PELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKE 252

Query: 272 TFEKGHIRDITDSLIEHCQEKQLDENANVQ-------LSDEKIINIVLDLFGAGFDTVTT 324
            F    I ++ D+L+   Q K   +N N         LSD  I+  + D+FGAG +T T+
Sbjct: 253 KFRSDSITNMLDTLM---QAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS 309

Query: 325 AISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPF 384
            + W+L +L+ NP+V++K+ EE+D  +G SR P +SDR+ L  +EA I E  R     P 
Sbjct: 310 VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM 369

Query: 385 TIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLS 444
            IPH    D+S+  F + KG  V +N W ++H++K W  P +F+PERFL P G      S
Sbjct: 370 LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS 429

Query: 445 EKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483
              + FG G R CIGE +AR E+FL +A LLQR +  VP
Sbjct: 430 VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVP 468


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  247 bits (630), Expect = 2e-65
 Identities = 154/491 (31%), Positives = 256/491 (52%), Gaps = 21/491 (4%)

Query: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSR 65
           M A+  LL +++ CL   V+ +   Q     K PPGP   P IG+ L L  +  + +L +
Sbjct: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 66  MSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSP 125
           +S++YG V  I +G   VVVL G D +R+ALV Q ++F GR +  TF  +  G  + FS 
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFS- 119

Query: 126 DSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFN 185
            +G      RR +   L+ F +           +EE + +EA  LI  L+    G  + +
Sbjct: 120 -NGERAKQLRRFSIATLRDFGVGKRG-------IEERIQEEAGFLIDALRG--TGGANID 169

Query: 186 PYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRY 242
           P  ++  +V+NVI +I FG R+D+  +E LSL+ +     +   +        F  ++++
Sbjct: 170 PTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKH 229

Query: 243 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQL 302
           LP P   AF+ L +    F+ K V+ + +T +    RD  DS +   QE++  +N N + 
Sbjct: 230 LPGPQQQAFQ-LLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEE--KNPNTEF 286

Query: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362
             + ++   L+LF  G +TV+T + +  + L+ +P V+ K+ EE+D VIG++R+P+  DR
Sbjct: 287 YLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR 346

Query: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422
           + +PYMEA I E  R    +P ++     +DT  + F++PKG  V+     +  D   + 
Sbjct: 347 AKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFS 406

Query: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482
           NP +F P+ FL   G   K  S+  + F +GKR C GE +AR E+FLF   ++Q      
Sbjct: 407 NPQDFNPQHFLNEKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKS 464

Query: 483 PLGVK-VDMTP 492
               K +D++P
Sbjct: 465 SQSPKDIDVSP 475


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  243 bits (621), Expect = 2e-64
 Identities = 154/492 (31%), Positives = 256/492 (52%), Gaps = 23/492 (4%)

Query: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHL--ALS 64
           M A+  LL +++ CL   V+ +   Q     K PPGP   P IG+ L L    H+  ++ 
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTE-HICDSIM 59

Query: 65  RMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFS 124
           + S+ YG V  I +G   VVVL G D +R+ALV Q ++F GR +  TF  +  G  ++FS
Sbjct: 60  KFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFS 119

Query: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF 184
             +G       R A   L+ F +           +EE + +E+  LI  ++       + 
Sbjct: 120 --NGERAKQLLRFAIATLRDFGVGKRG-------IEERIQEESGFLIEAIRSTHGA--NI 168

Query: 185 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILR 241
           +P  ++  +V+NVI +I FG R+D+  +E LSL+++     +   +        F  +++
Sbjct: 169 DPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMK 228

Query: 242 YLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ 301
           +LP P   AFK L +    F+ K V+ + +T +    +D  DS + H QE++  +N N +
Sbjct: 229 HLPGPQQQAFK-LLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEE--KNPNTE 285

Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361
              + ++   L+LF AG +TV+T + +  + L+ +P V+ K+ EE+D VIG++R+P+  D
Sbjct: 286 FYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFED 345

Query: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421
           R+ +PYMEA I E  R    +P ++     +DT  + F++PKG  VF     +  D   +
Sbjct: 346 RTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFF 405

Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481
            NP +F P+ FL   G   K  S+  + F +GKR C GE +AR E+FLF   ++Q     
Sbjct: 406 SNPQDFNPQHFLDDKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463

Query: 482 VPLGVK-VDMTP 492
                K +D++P
Sbjct: 464 SSQSPKDIDVSP 475


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  242 bits (617), Expect = 7e-64
 Identities = 145/453 (32%), Positives = 241/453 (53%), Gaps = 22/453 (4%)

Query: 40  PPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 98
           PPGP   P +G++L +  +N      ++ +++GDV  +++  TPVVVL+GL  +R+ALV 
Sbjct: 34  PPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT 93

Query: 99  QGDDFKGRPDLYTFTLISNGQSMS--FSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156
            G+D   RP +    ++  G      F    GP W  +RR + + L++  +         
Sbjct: 94  HGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKS----- 148

Query: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216
             LE+ V++EA  L +        P  F P   +  +V+NVI ++  GRR++++    L 
Sbjct: 149 --LEQWVTEEAACLCAAFANHSGRP--FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLR 204

Query: 217 LVNLNNNFGEVVGSG---NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF 273
           L++L    G    SG      + +P+L ++P  +    +   + F + + +++ EH  T+
Sbjct: 205 LLDLAQE-GLKEESGFLREVLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTW 262

Query: 274 EKGHI-RDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332
           +     RD+T++ +   ++ +   N     +DE +  +V DLF AG  T +T ++W L+ 
Sbjct: 263 DPAQPPRDLTEAFLAEMEKAK--GNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLL 320

Query: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 392
           ++++P VQR++Q+E+D VIG+ RRP + D++H+PY  A I E  R    VP  + H T+R
Sbjct: 321 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 380

Query: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452
           D  ++GF IPKG  +  N   +  D+ +W  P  F PE FL   G    V  E  + F  
Sbjct: 381 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF--VKPEAFLPFSA 438

Query: 453 GKRKCIGETIARWEVFLFLAILLQRVEFSVPLG 485
           G+R C+GE +AR E+FLF   LLQ   FSVP G
Sbjct: 439 GRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 471


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  241 bits (615), Expect = 1e-63
 Identities = 155/494 (31%), Positives = 267/494 (54%), Gaps = 29/494 (5%)

Query: 6   SMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHL-ALS 64
           S+S    LL   + CL+  +  +SR    KG K PPGP    ++G++L L     L +L+
Sbjct: 3   SISTAILLLLLALVCLLLTL--SSRD---KG-KLPPGPRPLSILGNLLLLCSQDMLTSLT 56

Query: 65  RMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFS 124
           ++S++YG +  + +G   VVVLSG   +++ALV QG++F GR D   F   + G  ++FS
Sbjct: 57  KLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFS 116

Query: 125 PDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHF 184
             SG  W   R+ +   L++F +           +EE + +E   L++ L++    P  F
Sbjct: 117 --SGDRWKVLRQFSIQILRNFGMGKRS-------IEERILEEGSFLLAELRKTEGEP--F 165

Query: 185 NPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGS--GNPADFIP-ILR 241
           +P   +  SV+N+IC++ FG R+D++ + LL+++ L N+  +++ S  G   D  P +L 
Sbjct: 166 DPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLD 225

Query: 242 YLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQ 301
           ++P P    F++  +     +   V +H  + +    RD     +    E++ D  ++  
Sbjct: 226 WVPGPHQRIFQNF-KCLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFH 284

Query: 302 LSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSD 361
           +  + ++    +L   G  TV+T +  + + L+  P+VQ ++QEE+D V+GR+R P L D
Sbjct: 285 M--DTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKD 342

Query: 362 RSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLW 421
           R+ +PY +A I E  R +  +P  +PH  TRDT+ +GF IPKG  V      +++D   +
Sbjct: 343 RAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQF 402

Query: 422 VNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFS 481
           + P EF PE FL  + +  K  S   + F  G+R C+GE++AR E+FL+L  +LQ     
Sbjct: 403 LTPQEFNPEHFLDANQSFKK--SPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQ 460

Query: 482 VPLGV--KVDMTPI 493
            PLG    +D+TP+
Sbjct: 461 -PLGAPEDIDLTPL 473


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  239 bits (610), Expect = 4e-63
 Identities = 150/485 (30%), Positives = 257/485 (52%), Gaps = 21/485 (4%)

Query: 14  LASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGD 72
           L  ++ CL   ++ +   Q     K PPGP   P+IG++L +G K+   +L+ +S+ YG 
Sbjct: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63

Query: 73  VLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWA 132
           V  +  G  P+VVL G + +++AL+  G++F GR         + G  + FS  +G  W 
Sbjct: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWK 121

Query: 133 ARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVV 192
             RR +   L++F +           +E+ V +EA  L+  L++  A P   +P   +  
Sbjct: 122 EIRRFSLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTKASP--CDPTFILGC 172

Query: 193 SVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRYLPNPSLN 249
           +  NVIC+I F +R+D+  Q+ L+L+   N   +++ S       +F PI+ Y P     
Sbjct: 173 APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNK 232

Query: 250 AFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIIN 309
             K++     S++ + VKEH ++ +  + +D  D  +   ++++   N   + + E + N
Sbjct: 233 LLKNV-AFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEK--HNQPSEFTIESLEN 289

Query: 310 IVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYME 369
             +DLFGAG +T +T + ++L+ L+ +P V  K+QEE++ VIGR+R P + DRSH+PY +
Sbjct: 290 TAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTD 349

Query: 370 AFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLP 429
           A + E  R+   +P ++PH+ T D   + + IPKG  + ++   + HD K + NP  F P
Sbjct: 350 AVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDP 409

Query: 430 ERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-V 488
             FL   G   K  S+  + F  GKR C+GE +A  E+FLFL  +LQ       +  K +
Sbjct: 410 HHFLDEGGNFKK--SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNL 467

Query: 489 DMTPI 493
           D TP+
Sbjct: 468 DTTPV 472


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  239 bits (610), Expect = 4e-63
 Identities = 149/501 (29%), Positives = 251/501 (50%), Gaps = 35/501 (6%)

Query: 13  LLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYG 71
           LL +V F L    ++  RP+       PPGPW  P +G+   +  +  HL +    ++YG
Sbjct: 22  LLGTVAFLLAADFLKRRRPK-----NYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYG 76

Query: 72  DVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRP--DLYTFTLISNGQSMSFSPDSGP 129
           ++  + +G    V+++GL  I++AL+    +F  RP   +       NG  MS    SG 
Sbjct: 77  NLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMS----SGQ 132

Query: 130 VWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRY 189
            W  +RR     L++F +           LEE + +EA+ L   ++E    P  F+P+  
Sbjct: 133 AWKEQRRFTLTALRNFGLGKKS-------LEERIQEEAQHLTEAIKEENGQP--FDPHFK 183

Query: 190 VVVSVTNVICAICFGRRYDHNH---QELLSLVNLNNNFGEVVGSGNPADFIP-ILRYLPN 245
           +  +V+N+IC+I FG R+++     Q+LL L++    + E   +    +  P I+++LP 
Sbjct: 184 INNAVSNIICSITFGERFEYQDSWFQQLLKLLD-EVTYLEASKTCQLYNVFPWIMKFLPG 242

Query: 246 PSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDE 305
           P    F +  +K   F+  M+ +H K +     RD  D+ ++   +     N      +E
Sbjct: 243 PHQTLFSNW-KKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHT--GNPTSSFHEE 299

Query: 306 KIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHL 365
            +I   LDLF AG +T +T + W+L+Y+ + P +Q K+Q E+D VIG+ ++P  + R  +
Sbjct: 300 NLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESM 359

Query: 366 PYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPS 425
           PY  A I E  R  + +P  +P   T DT+L G+++PKG  +  N   ++ D   W  P 
Sbjct: 360 PYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPD 419

Query: 426 EFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLG 485
            F P+ FL  +G   K   E  + F +GKR C+GE +AR E+F+F   L+Q+  F  P  
Sbjct: 420 TFNPDHFL-ENGQFKK--REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNN 476

Query: 486 VKVDMTPIYGLT---MKHACC 503
            K+ +    G+T   + H  C
Sbjct: 477 EKLSLKFRMGITISPVSHRLC 497


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  237 bits (604), Expect = 2e-62
 Identities = 155/487 (31%), Positives = 249/487 (51%), Gaps = 29/487 (5%)

Query: 13  LLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYG 71
           L  S +F L  W   + R ++P G      P   P+IG++L L  K+   +L+  S+ YG
Sbjct: 9   LCLSCLFLLSLWRQSSGRGRLPSG------PTPLPIIGNILQLDVKDMSKSLTNFSKVYG 62

Query: 72  DVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVW 131
            V  +  G  P+VVL G + +++AL+  G++F GR        ++ G  + FS  +G  W
Sbjct: 63  PVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFS--NGKRW 120

Query: 132 AARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVV 191
              RR     L++F +           +E+ V +EA  L+  L++  A P   +P   + 
Sbjct: 121 KEIRRFCLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTNASP--CDPTFILG 171

Query: 192 VSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRYLPNPSL 248
            +  NVIC++ F  R+D+  Q  L+L+   N    ++ S       +F  ++ YLP  S 
Sbjct: 172 CAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPG-SH 230

Query: 249 NAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDS-LIEHCQEKQLDENANVQLSDEKI 307
           N   +      S++ + +KEH ++ +    RD  D  LI+  QEK    N   + + E +
Sbjct: 231 NKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKH---NQQSEFTVESL 287

Query: 308 INIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367
           I  V D+FGAG +T +T + + L+ L+  P V  K+QEE++ V+GR+R P + DRSH+PY
Sbjct: 288 IATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPY 347

Query: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF 427
            +A + E  R+   +P  +PH+ T D   K + IPKG  +  +   + H+ K + NP  F
Sbjct: 348 TDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMF 407

Query: 428 LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK 487
            P  FL   G   K  S+  + F  GKR C+GE +AR E+FLFL  +LQ       +  K
Sbjct: 408 DPGHFLDKSGNFKK--SDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPK 465

Query: 488 -VDMTPI 493
            +D+TPI
Sbjct: 466 DIDITPI 472


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  234 bits (597), Expect = 1e-61
 Identities = 151/469 (32%), Positives = 245/469 (52%), Gaps = 30/469 (6%)

Query: 17  VIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQ 75
           ++ CL F ++ +   Q  +  K PPGP   P+IG+ML +  K+   + +  S+ YG V  
Sbjct: 7   LVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFT 66

Query: 76  IRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARR 135
           +  G  P+VV  G + +++AL+  G++F GR +      I+ G  +  S  +G  W   R
Sbjct: 67  VYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISS--NGKRWKEIR 124

Query: 136 RLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT 195
           R +   L++F +           +E+ V +EA  L+  L++  A P   +P   +  +  
Sbjct: 125 RFSLTTLRNFGMGKRS-------IEDRVQEEAHCLVEELRKTKASP--CDPTFILGCAPC 175

Query: 196 NVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLN 255
           NVIC++ F +R+D+  Q  L+L+   N    ++ S     +I +    P   ++ F   +
Sbjct: 176 NVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNS----PWIQVCNNFPL-LIDCFPGTH 230

Query: 256 EKFY-------SFMQKMVKEHYKTFEKGHIRDITDS-LIEHCQEKQLDENANVQLSDEKI 307
            K         S++++ VKEH  + +  + RD  D  LI+  QEK   +N   + + E +
Sbjct: 231 NKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEK---DNQKSEFNIENL 287

Query: 308 INIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPY 367
           +  V DLF AG +T +T + + L+ L+ +P V  K+QEE+D VIGR R P + DRSH+PY
Sbjct: 288 VGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPY 347

Query: 368 MEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF 427
            +A + E  R+S  VP  +PH+ T DT  + + IPKG  +      + HD K + NP+ F
Sbjct: 348 TDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIF 407

Query: 428 LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476
            P  FL  +G   K  S+  + F  GKR C GE +AR E+FLFL  +LQ
Sbjct: 408 DPGHFLDKNGNFKK--SDYFMPFSAGKRICAGEGLARMELFLFLTTILQ 454


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  233 bits (594), Expect = 3e-61
 Identities = 146/459 (31%), Positives = 243/459 (52%), Gaps = 23/459 (5%)

Query: 40  PPGPWGWPLIGHMLTLGKNPHL-ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 98
           PPGP   PL+G++L + +   L +  R  ++YGDV  + +G  PVV+L G++ IR+ALV 
Sbjct: 31  PPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVD 90

Query: 99  QGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 158
           + + F GR  +        G  + F+  +G  W   RR +   ++ F +           
Sbjct: 91  KAEAFSGRGKIAMVDPFFRGYGVIFA--NGNRWKVLRRFSVTTMRDFGMGKRS------- 141

Query: 159 LEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT-NVICAICFGRRYDHNHQELLSL 217
           +EE + +EA+ LI   +EL    G      ++  S+T N+IC+I FG+R+ +  QE L +
Sbjct: 142 VEERIQEEAQCLI---EELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKM 198

Query: 218 VNLNNNFGEVVGS--GNPAD-FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFE 274
           +NL      ++ S  G   + F   L+Y P      +K+L E   +++   V++H +T +
Sbjct: 199 LNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE-INAYIGHSVEKHRETLD 257

Query: 275 KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334
               +D+ D+ + H ++++   NA+ + S + +    L LF AG +T +T + +  + ++
Sbjct: 258 PSAPKDLIDTYLLHMEKEK--SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLML 315

Query: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 394
             P V  ++  E++ VIG  R P L DR+ +PY EA I E  R S  +P  +PH  T+ T
Sbjct: 316 KYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHT 375

Query: 395 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 454
           S +G+ IPK   VF+      HD   +  P  F P+ FL  +GA+ K  +E  I F +GK
Sbjct: 376 SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK--TEAFIPFSLGK 433

Query: 455 RKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTP 492
           R C+GE IAR E+FLF   +LQ    + P+  + +D+TP
Sbjct: 434 RICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTP 472


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  228 bits (581), Expect = 1e-59
 Identities = 148/462 (32%), Positives = 241/462 (52%), Gaps = 23/462 (4%)

Query: 38  KNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96
           K PPGP   P+IG++L +  K+   +L+ +S+ YG V  +  G   +VVL G + +++AL
Sbjct: 28  KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 87

Query: 97  VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156
           +  G++F GR         + G  + FS  +G  W   RR +   L++F +         
Sbjct: 88  IDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMGKRS----- 140

Query: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216
             +E+ V +EA  L+  L++  A P   +P   +  +  NVIC+I F +R+D+  Q+ L+
Sbjct: 141 --IEDRVQEEARCLVEELRKTKASP--CDPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 196

Query: 217 LVNLNNNFGEVVGSGNPA---DFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF 273
           L+   N    +V +       +F  I+ Y P       K+L       ++K VKEH ++ 
Sbjct: 197 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESM 255

Query: 274 EKGHIRDITDS-LIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332
           +  + RD  D  LI+  +EKQ   N   + + E ++    DL GAG +T +T + ++L+ 
Sbjct: 256 DINNPRDFIDCFLIKMEKEKQ---NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLL 312

Query: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 392
           L+ +P V  K+QEE++ VIGR+R P + DR H+PY +A + E  R+   +P ++PH+ T 
Sbjct: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC 372

Query: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452
           D   + + IPKG  +  +   + HD K + NP  F P  FL   G   K  S   + F  
Sbjct: 373 DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--SNYFMPFSA 430

Query: 453 GKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPI 493
           GKR C+GE +AR E+FLFL  +LQ       +  K +D TP+
Sbjct: 431 GKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  226 bits (576), Expect = 4e-59
 Identities = 152/493 (30%), Positives = 254/493 (51%), Gaps = 23/493 (4%)

Query: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSR 65
           MSA    +A +++     ++   R QV      PPGP+  P+IG++  L  KN   + +R
Sbjct: 1   MSALGVTVALLVWAAFLLLVSMWR-QVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTR 59

Query: 66  MSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSP 125
           ++Q++G V  + +GS  +VV+ G   +++AL+   D+F GR DL  F      + + F+ 
Sbjct: 60  LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHA-HRDRGIIFN- 117

Query: 126 DSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFN 185
            +GP W   RR +   L+++ +            E  + +EA  L+  L++    P  F+
Sbjct: 118 -NGPTWKDIRRFSLTTLRNYGMGKQGN-------ESRIQREAHFLLEALRKTQGQP--FD 167

Query: 186 PYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNL-NNNFGEVVGSGNPA--DFIPILRY 242
           P   +  +  NVI  I F + +D+N ++ L L+ L N NF  +         +F   L Y
Sbjct: 168 PTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHY 227

Query: 243 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQL 302
           LP       K++ E    ++ + VKEH+++ +    RD+TD L+   ++++   +A    
Sbjct: 228 LPGSHRKVIKNVAE-VKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEK--HSAERLY 284

Query: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362
           + + I   V DLF AG +T +T + + L+ L+  P ++ K+ EE+D VIG SR P + DR
Sbjct: 285 TMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDR 344

Query: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422
             +PYM+A + E  R  + VP  +PH  TRDT  +G+ IPKG  V      + +D + + 
Sbjct: 345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFP 404

Query: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482
           +P +F PE FL  +G      S+    F  GKR C GE +AR E+FL L  +LQ      
Sbjct: 405 DPEKFKPEHFLNENGKFK--YSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKP 462

Query: 483 PLGVK-VDMTPIY 494
            +  K +D++PI+
Sbjct: 463 LVDPKDIDLSPIH 475


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  216 bits (549), Expect = 5e-56
 Identities = 138/496 (27%), Positives = 246/496 (49%), Gaps = 29/496 (5%)

Query: 14  LASVIFCLVF--WVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKN---PHLALSRMSQ 68
           L   +F L+F   V +  + + P G   PPGP G P IG++ +L  +   PH+ + + SQ
Sbjct: 14  LGGALFLLLFALGVRQLLKQRRPMGF--PPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ 71

Query: 69  QYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSG 128
            YG++  + +G    VVL+G D +++ LV Q + F  RP L  F  ++    +  +   G
Sbjct: 72  VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGL-LNSRYG 130

Query: 129 PVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYR 188
             W   RRLA N  + F              E  + +E +     ++     P  F   +
Sbjct: 131 RGWVDHRRLAVNSFRYFGYGQKS-------FESKILEETKFFNDAIETYKGRPFDFK--Q 181

Query: 189 YVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG-----NPADFIPILRYL 243
            +  +V+N+   I FG R+ +   +   ++ L +   E+  S      N   +I IL + 
Sbjct: 182 LITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFG 241

Query: 244 PNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLS 303
            +  L  F++     Y F+ +++++     +    +   D+ ++   + + D ++    S
Sbjct: 242 KHQQL--FRNA-AVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSST--FS 296

Query: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363
            E +I  V +L  AG +T T  + W+++++ + P +Q ++Q+E+D ++G + +P   D+ 
Sbjct: 297 KENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKC 356

Query: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423
            +PY EA + E  R  + VP  I H+T+ D  ++G+ IPKG  V  N + ++ D+K W +
Sbjct: 357 KMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRD 416

Query: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483
           P  F PERFL   G   K   E ++ F +G+R C+GE +AR E+FLF   LLQR     P
Sbjct: 417 PEVFHPERFLDSSGYFAK--KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 474

Query: 484 LGVKVDMTPIYGLTMK 499
             +  D+ P  G+T++
Sbjct: 475 HELVPDLKPRLGMTLQ 490


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  209 bits (532), Expect = 5e-54
 Identities = 138/451 (30%), Positives = 222/451 (49%), Gaps = 69/451 (15%)

Query: 40  PPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 98
           PPGP   P +G++L +  +N      ++ +++GDV  +++  TPVVVL+GL  +R+ALV 
Sbjct: 34  PPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT 93

Query: 99  QGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCY 158
            G+D   RP       +   Q + F P S       R    NGL                
Sbjct: 94  HGEDTADRPP------VPITQILGFGPRS-----QGRPFRPNGL---------------- 126

Query: 159 LEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLV 218
           L++ VS                               NVI ++  GRR++++    L L+
Sbjct: 127 LDKAVS-------------------------------NVIASLTCGRRFEYDDPRFLRLL 155

Query: 219 NLNNNFGEVVGSG---NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 275
           +L    G    SG      + +P+L ++P  +    +   + F + + +++ EH  T++ 
Sbjct: 156 DLAQE-GLKEESGFLREVLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDP 213

Query: 276 GH-IRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV 334
               RD+T++ +   ++ +   N     +DE +  +V DLF AG  T +T ++W L+ ++
Sbjct: 214 AQPPRDLTEAFLAEMEKAK--GNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMI 271

Query: 335 MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDT 394
           ++P VQR++Q+E+D VIG+ RRP + D++H+PY  A I E  R    VP  + H T+RD 
Sbjct: 272 LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDI 331

Query: 395 SLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGK 454
            ++GF IPKG  +  N   +  D+ +W  P  F PE FL   G    V  E  + F  G+
Sbjct: 332 EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF--VKPEAFLPFSAGR 389

Query: 455 RKCIGETIARWEVFLFLAILLQRVEFSVPLG 485
           R C+GE +AR E+FLF   LLQ   FSVP G
Sbjct: 390 RACLGEPLARMELFLFFTSLLQHFSFSVPTG 420


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  207 bits (527), Expect = 2e-53
 Identities = 147/486 (30%), Positives = 243/486 (50%), Gaps = 39/486 (8%)

Query: 40  PPGPWGWPLIGHMLTLGKNP-HLALSRMSQQYGDVLQIRIGS-TPVVVLSGLDTIRQALV 97
           PPGP   PL+G++L L     +  L R+S++YG V  I +G   PVVVL G + +R+AL 
Sbjct: 33  PPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALG 92

Query: 98  RQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSC 157
            Q ++F GR  +       +G  + FS  +G  W   R+     L+   +          
Sbjct: 93  GQAEEFSGRGTVAMLEGTFDGHGVFFS--NGERWRQLRKFTMLALRDLGMGKREG----- 145

Query: 158 YLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSL 217
             EE +  EA  L+ T Q     P  F+P   +  + +NV+C++ FG R+ +  +E  ++
Sbjct: 146 --EELIQAEARCLVETFQGTEGRP--FDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAV 201

Query: 218 VNLNNNFGEVVGSGNPAD-----FIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKT 272
           V      G ++G  +        F   LR LP P       ++    +F  + V++H   
Sbjct: 202 VRAAG--GTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVST-LAAFTVRQVQQHQGN 258

Query: 273 FE-KGHIRDITDS-LIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSL 330
            +  G  RD+ D+ L++  QE+Q   N   + +++ ++  V+ L  AG  TV+T + ++L
Sbjct: 259 LDASGPARDLVDAFLLKMAQEEQ---NPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTL 315

Query: 331 MYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHST 390
           + L+  P VQ+ ++EEL+  +G  + P L DR+ LPY +A + E  R  + VP  IP + 
Sbjct: 316 LLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTL 375

Query: 391 TRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF 450
            R T  +G+ +P+G  VF     I HD  ++ +P EF P+RFL  DG   K   E  + F
Sbjct: 376 MRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRK--HEAFLPF 433

Query: 451 GMGKRKCIGETIARWEVFLFLAILLQRVEFSVP-----LGVKVDMTPIYGLTMKHACCEH 505
            +GKR C+GE +A+ E+FLF   +LQ      P     L +K  ++ ++ +         
Sbjct: 434 SLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIP------PA 487

Query: 506 FQMQLR 511
           FQ+Q+R
Sbjct: 488 FQLQVR 493


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  206 bits (525), Expect = 3e-53
 Identities = 144/484 (29%), Positives = 226/484 (46%), Gaps = 82/484 (16%)

Query: 13  LLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYG 71
           L  S +F L  W   + R ++P G      P   P+IG++L L  K+   +L+  S+ YG
Sbjct: 9   LCLSCLFLLSLWRQSSGRGRLPSG------PTPLPIIGNILQLDVKDMSKSLTNFSKVYG 62

Query: 72  DVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVW 131
            V  +  G  P+VVL G + +++AL+  G++F GR        ++ G  + FS  +G  W
Sbjct: 63  PVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFS--NGKRW 120

Query: 132 AARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVV 191
              RR     L++F +           +E+ V +EA  L+  L++  A P   +P   + 
Sbjct: 121 KEIRRFCLMTLRNFGMGKRS-------IEDRVQEEARCLVEELRKTNASP--CDPTFILG 171

Query: 192 VSVTNVICAICFGRRYDHNHQELLSLVN-LNNNFGEVVGSGNPADFIPILRYLPNPSLNA 250
            +  NVIC++ F  R+D+  Q  L+L+   N N                LR L +P +  
Sbjct: 172 CAPCNVICSVIFHDRFDYKDQRFLNLMEKFNEN----------------LRILSSPWI-- 213

Query: 251 FKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINI 310
                                                  QEK    N   + + E +I  
Sbjct: 214 ---------------------------------------QEKH---NQQSEFTVESLIAT 231

Query: 311 VLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEA 370
           V D+FGAG +T +T + + L+ L+  P V  K+QEE++ V+GR+R P + DRSH+PY +A
Sbjct: 232 VTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDA 291

Query: 371 FILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPE 430
            + E  R+   +P  +PH+ T D   K + IPKG  +  +   + H+ K + NP  F P 
Sbjct: 292 VVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPG 351

Query: 431 RFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VD 489
            FL   G   K  S+  + F  GKR C+GE +AR E+FLFL  +LQ       +  K +D
Sbjct: 352 HFLDKSGNFKK--SDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDID 409

Query: 490 MTPI 493
           +TPI
Sbjct: 410 ITPI 413


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  195 bits (496), Expect = 7e-50
 Identities = 147/498 (29%), Positives = 234/498 (46%), Gaps = 34/498 (6%)

Query: 13  LLASVIFCLVFWVIRASRPQVPK-GLKNPPGPWGWPLIG--HMLTLGKNPHLALSRMSQQ 69
           LL   +  L  W +  +  Q P    + PPGP   PL+G  H+L L +    +L  +S++
Sbjct: 4   LLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDR-SLMELSER 62

Query: 70  YGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGP 129
           YG V  + +G    VVL+G + +++AL   G +   RP +  F LI  G  + FS  SG 
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFS--SGA 120

Query: 130 VWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRY 189
            W A R+     L S  +  +P +       + + +E + L   L      P    P   
Sbjct: 121 RWRAARQFTVRALHSLGVGREPVA-------DKILQELKCLSGQLDGYRGRPF---PLAL 170

Query: 190 VVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSG-----NPADFIPILRYLP 244
           +  + +N+  A+ FGRR+D+     +SL+ L +    ++GS      N   ++  L  L 
Sbjct: 171 LGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLH 230

Query: 245 NPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSD 304
            P L   +++     + ++   + H    +   +    D+LI   Q+ Q D+   +  ++
Sbjct: 231 RPVLRKIEEVRAILRTLLEAR-RPHVCPGDP--VCSYVDALI---QQGQGDDPEGL-FAE 283

Query: 305 EKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSH 364
              +   LD+  AG +T +  + W+ + +  +P VQ ++QEELD V+G  R PRL D+  
Sbjct: 284 ANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQA 343

Query: 365 LPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNP 424
           LPY  A + E  R  + +P  +P  T  DT L GF +PKG  V      +  D+  W  P
Sbjct: 344 LPYTSAVLHEVQRFITLLPH-VPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTP 402

Query: 425 SEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPL 484
            +F P  FL  +G    V  E  + F  G+R C+GE +AR E+FL  A LLQR     P 
Sbjct: 403 GQFNPGHFLDANGHF--VKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPP 460

Query: 485 GV---KVDMTPIYGLTMK 499
           GV    +D TP    TM+
Sbjct: 461 GVSPASLDTTPARAFTMR 478


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  188 bits (477), Expect = 1e-47
 Identities = 135/490 (27%), Positives = 225/490 (45%), Gaps = 70/490 (14%)

Query: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRM 66
           M A+  LL +++ CL   V+ +   Q     K PPGP   P IG+ L L    H+  S M
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTE-HICDSIM 59

Query: 67  SQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPD 126
               G            V  S  +  +Q L                              
Sbjct: 60  KVSQG------------VAFSNGERAKQLL------------------------------ 77

Query: 127 SGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNP 186
                    R A   L+ F +           +EE + +E+  LI  ++       + +P
Sbjct: 78  ---------RFAIATLRDFGVGKRG-------IEERIQEESGFLIEAIRSTHGA--NIDP 119

Query: 187 YRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRYL 243
             ++  +V+NVI +I FG R+D+  +E LSL+++     +   +        F  ++++L
Sbjct: 120 TFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHL 179

Query: 244 PNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLS 303
           P P   AFK L +    F+ K V+ + +T +    +D  DS + H QE++  +N N +  
Sbjct: 180 PGPQQQAFK-LLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEE--KNPNTEFY 236

Query: 304 DEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRS 363
            + ++   L+LF AG +TV+T + +  + L+ +P V+ K+ EE+D VIG++R+P+  DR+
Sbjct: 237 LKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRT 296

Query: 364 HLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVN 423
            +PYMEA I E  R    +P ++     +DT  + F++PKG  VF     +  D   + N
Sbjct: 297 KMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSN 356

Query: 424 PSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 483
           P +F P+ FL   G   K  S+  + F +GKR C GE +AR E+FLF   ++Q       
Sbjct: 357 PQDFNPQHFLDDKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 414

Query: 484 LGVK-VDMTP 492
              K +D++P
Sbjct: 415 QSPKDIDVSP 424


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  183 bits (464), Expect = 4e-46
 Identities = 123/425 (28%), Positives = 207/425 (48%), Gaps = 42/425 (9%)

Query: 66  MSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSP 125
           ++Q++G + ++ +G   VVVL+   TI +A+V++  DF GRP+  T+ L+S         
Sbjct: 52  LTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLG 111

Query: 126 DSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELM-AGPGHF 184
           D   +W A ++L ++ L                + + +    E L     E M A PG  
Sbjct: 112 DYSLLWKAHKKLTRSALL-------------LGIRDSMEPVVEQLTQEFCERMRAQPGTP 158

Query: 185 NPYRYVVVSVT-NVICAICFGRRYDHNH---------QELLSLVNLNNNFGEVVGSGNPA 234
                    +T ++IC + FG +   ++         QE+L   +          S    
Sbjct: 159 VAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSH--------WSIQIV 210

Query: 235 DFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQL 294
           D IP LR+ PNP L   K   EK    ++  +++H ++   G  RD+ D +++   +  +
Sbjct: 211 DVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSM 270

Query: 295 DENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIG-- 352
           +E +  QL +  +    +DL   G +T    +SW++++L+ +P +Q+++QEELD  +G  
Sbjct: 271 EEGSG-QLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPG 329

Query: 353 -RSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQ 411
             S R    DR+ LP + A I E  R    VP  +PH TTR +S+ G+ IP+G  +  N 
Sbjct: 330 ASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNL 389

Query: 412 WQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471
              + D+ +W  P EF P+RFL P        + + + FG G R C+GE +AR E+F+ L
Sbjct: 390 QGAHLDETVWERPHEFWPDRFLEPG------KNSRALAFGCGARVCLGEPLARLELFVVL 443

Query: 472 AILLQ 476
             LLQ
Sbjct: 444 TRLLQ 448


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  155 bits (393), Expect = 6e-38
 Identities = 83/245 (33%), Positives = 134/245 (54%), Gaps = 10/245 (4%)

Query: 235 DFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQL 294
           D IP LR+ PNP L   K   EK    ++  +++H ++   G  RD+ D +++   +  +
Sbjct: 181 DVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSM 240

Query: 295 DENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIG-- 352
           +E +  QL +  +    +DL   G +T    +SW++++L+ +P +Q+++QEELD  +G  
Sbjct: 241 EEGSG-QLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPG 299

Query: 353 -RSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQ 411
             S R    DR+ LP + A I E  R    VP  +PH TTR +S+ G+ IP+G  +  N 
Sbjct: 300 ASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNL 359

Query: 412 WQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471
              + D+ +W  P EF P+RFL P        + + + FG G R C+GE +AR E+F+ L
Sbjct: 360 QGAHLDETVWERPHEFWPDRFLEPG------KNSRALAFGCGARVCLGEPLARLELFVVL 413

Query: 472 AILLQ 476
             LLQ
Sbjct: 414 TRLLQ 418


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  105 bits (262), Expect = 1e-22
 Identities = 115/459 (25%), Positives = 195/459 (42%), Gaps = 52/459 (11%)

Query: 41  PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQG 100
           PGP   PL+G++L+  +      +   ++YG +     G  PV+ ++  D IR  LV++ 
Sbjct: 39  PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKEC 98

Query: 101 DD-FKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKS------FSIASDPAS 153
              F  R  L     + +  S++   +    W   R L      S      F I +    
Sbjct: 99  YSVFTNRRSLGPVGFMKSAISLAEDEE----WKRIRSLLSPTFTSGKLKEMFPIIAQYGD 154

Query: 154 STSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQE 213
                L     K   V   TL+++      F  Y   V++ T+      FG   D  +  
Sbjct: 155 VLVRNLRREAEKGKPV---TLKDI------FGAYSMDVITGTS------FGVNIDSLNNP 199

Query: 214 LLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLN-AFKDLNEKFY-----SFMQKMVK 267
               V     F +  G  +P  F+ I+ +   P L   F+ LN   +     +F+ K V 
Sbjct: 200 QDPFVESTKKFLKF-GFLDPL-FLSIILF---PFLTPVFEALNVSLFPKDTINFLSKSVN 254

Query: 268 EHYKTF---EKGHIRDITDSLIEHCQEKQLDEN---ANVQLSDEKIINIVLDLFGAGFDT 321
              K+    ++ H  D    +I+    K+ + +   ++++L+ + II I      AG++T
Sbjct: 255 RMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF-----AGYET 309

Query: 322 VTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSF 381
            ++ +S++L  L  +P VQ+K+Q+E+D V+     P       + Y++  + ET R    
Sbjct: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFP- 368

Query: 382 VPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDK 441
           V   +  +  +D  + G +IPKG  V +  + ++HD K W  P EF PERF     +ID 
Sbjct: 369 VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDP 428

Query: 442 VLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480
            +      FG G R CIG   A   + L L  +LQ   F
Sbjct: 429 YIYTP---FGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  104 bits (260), Expect = 2e-22
 Identities = 107/476 (22%), Positives = 200/476 (42%), Gaps = 65/476 (13%)

Query: 41  PGPWGWPLIGHMLTLG-----KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQA 95
           PGP  WPL+G +L +      K  H  L    ++YG + ++++GS   V L G   + +A
Sbjct: 59  PGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GSPCLLEA 117

Query: 96  LVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASST 155
           L R    +               Q +   P     W A R   + G     +  +     
Sbjct: 118 LYRTESAYP--------------QRLEIKP-----WKAYRDYRKEGYGLLILEGEDWQRV 158

Query: 156 SCYLEEHVSKEAEVL-------------ISTLQELMAGPGHFNP-YRYVVVSVTNVICAI 201
               ++ + K  EV+             +  + EL    GH    Y  +       IC +
Sbjct: 159 RSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLV 218

Query: 202 CFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSF 261
            + +R+            L  N G+        +FI  ++ + +          E   S 
Sbjct: 219 LYEKRFGL----------LQKNAGD-----EAVNFIMAIKTMMSTFGRMMVTPVELHKSL 263

Query: 262 MQKMVKEH---YKTFEKGHIRDITDSLIEHCQEKQLDENANV----QLSDEKIINIVLDL 314
             K+ ++H   + T  K     I + L ++ Q+   D   ++    +LS +++   V +L
Sbjct: 264 NTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTEL 323

Query: 315 FGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILE 374
             A  +T   ++ W L  L  NP+VQ+K+ +E+ +V+  ++ PR  D  ++PY++A + E
Sbjct: 324 QLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKE 383

Query: 375 TFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLT 434
           + R +  VPFT   +  + T L  + +PKG  + +N   +   +  + + S+F PER+L 
Sbjct: 384 SMRLTPSVPFT-TRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQ 442

Query: 435 PDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDM 490
                +K+     + FG+GKR CIG  +A  ++ L L  ++++ +        V+M
Sbjct: 443 EK---EKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEM 495


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  104 bits (259), Expect = 2e-22
 Identities = 112/459 (24%), Positives = 185/459 (40%), Gaps = 57/459 (12%)

Query: 46  WPLIGHMLTL---GKNPHLALSRMSQQYGDV--LQIRIGSTPVVVLSGLDTIRQALVRQG 100
           +PL+GH L +   G+     +   +++Y  +  L++ +G  P+V L   + +   L    
Sbjct: 57  YPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSK 116

Query: 101 DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNG-----LKSF-SIASDPASS 154
              K    +Y F  +     +     +G  W +RR++         L+ F  I ++ A+ 
Sbjct: 117 QIDKS--SMYKF--LEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANI 172

Query: 155 TSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQEL 214
               LE+H+++EA                FN + Y+ +   ++IC    G+       + 
Sbjct: 173 LVKKLEKHINQEA----------------FNCFFYITLCALDIICETAMGKNIGAQSNDD 216

Query: 215 LSLVNLNNNFGEVVGSGNPADFIPI-LRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF 273
              V       E++       ++ + L YL        K   +  ++F   ++ E     
Sbjct: 217 SEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEM 276

Query: 274 E---------------KGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAG 318
                           K   R   D L+        D+  N +LS E I   V      G
Sbjct: 277 NANEDCRGDGRGSAPSKNKRRAFLDLLLS-----VTDDEGN-RLSHEDIREEVDTFMFEG 330

Query: 319 FDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRP-RLSDRSHLPYMEAFILETFR 377
            DT   AI+WSL  L  NP VQ+K+  ELD V G+S RP  + D   L Y+E  I ET R
Sbjct: 331 HDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLR 390

Query: 378 HSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDG 437
               VP     S + D  + G+ + KG    +  + ++ D + + NP EF PERF  P+ 
Sbjct: 391 LFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFF-PEN 448

Query: 438 AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQ 476
           A  +      + F  G R CIG+  A  E    L+ +L+
Sbjct: 449 AQGR-HPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILR 486


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  103 bits (256), Expect = 5e-22
 Identities = 116/458 (25%), Positives = 193/458 (42%), Gaps = 49/458 (10%)

Query: 41  PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQG 100
           PGP   P +G+ L+  K          ++Y  V  I     P++ ++  D I+  LV++ 
Sbjct: 39  PGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKEC 98

Query: 101 DD-FKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYL 159
              F  R        + N  S++   +    W   R L               + TS  L
Sbjct: 99  YSVFTNRRPFGPVGFMKNAISIAEDEE----WKRIRSLLS------------PTFTSGKL 142

Query: 160 EEHV---SKEAEVLISTLQELMAGPGHFNPYRYVVVSVT-NVICAICFGRRYDHNHQELL 215
           +E V   ++  +VL+  L+   A  G     ++V  + + +VI +  FG   D       
Sbjct: 143 KEMVPIIAQYGDVLVRNLRR-EAETGKPVTLKHVFGAYSMDVITSTSFGVSID------- 194

Query: 216 SLVNLNNNFGEVVGS---GNPAD-FIPILRYLP--NPSLNAFKD--LNEKFYSFMQKMVK 267
           SL N  + F E        NP D F+  ++  P   P L A        K  SF+ K VK
Sbjct: 195 SLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVK 254

Query: 268 EHYKTFEKGHIRDITDSLIEHCQ-----EKQLDENANVQLSDEKIINIVLDLFGAGFDTV 322
           +     ++G +++     ++  Q     +   D   +  LSD +++   +    AG++T 
Sbjct: 255 Q----IKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETT 310

Query: 323 TTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFV 382
           ++ +S+ +  L  +P VQ+K+Q+E+DTV+     P       L Y++  + ET R    V
Sbjct: 311 SSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFP-V 369

Query: 383 PFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKV 442
              +     +D  + G +IPKG  V +  + ++HD K W  P +FLPERF   +   D +
Sbjct: 370 AMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNK--DNI 427

Query: 443 LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 480
                  FG G R CIG   A   + L L  +LQ   F
Sbjct: 428 DPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSF 465


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  102 bits (255), Expect = 6e-22
 Identities = 110/470 (23%), Positives = 192/470 (40%), Gaps = 43/470 (9%)

Query: 41  PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQG 100
           PGP   P +G +L   +         +++YG++  +  G  P++V+   D I+  LV++ 
Sbjct: 39  PGPTPLPFLGTILFYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKEC 98

Query: 101 DD-FKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYL 159
              F  +  L     + +  ++SF+ D    W   R L      S          + C  
Sbjct: 99  YSVFTNQMPLGPMGFLKS--ALSFAEDEE--WKRIRTLLSPAFTSVKFKEMVPIISQC-- 152

Query: 160 EEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVN 219
                   ++L+ +L++        N   +      +VI    FG   D       SL N
Sbjct: 153 -------GDMLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLD-------SLNN 198

Query: 220 LNNNFGEVVGSGNPADFI-PILRYLP-----NPSLNAF------KDLNEKFYSFMQKMVK 267
             + F + +      DF+ P L  +       P   A       KD+     + +++M +
Sbjct: 199 PQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKE 258

Query: 268 EHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAIS 327
              K  +K H  D    +I+    K+    ++  LSD +++   + +  A +DT +T + 
Sbjct: 259 SRLKDKQK-HRVDFFQQMIDSQNSKET--KSHKALSDLELVAQSIIIIFAAYDTTSTTLP 315

Query: 328 WSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP 387
           + +  L  +P VQ+K+QEE+D V+             + Y++  + ET R    V   + 
Sbjct: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVS-RVT 374

Query: 388 HSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV 447
               +D  + G +IPKG  V V  + ++HD K W  P +F PERF   +   D +   + 
Sbjct: 375 RVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNK--DSIDLYRY 432

Query: 448 IIFGMGKRKCIGETIARWEVFLFLAILLQRVEF----SVPLGVKVDMTPI 493
           I FG G R CIG   A   + L +   LQ   F       + +K+D  PI
Sbjct: 433 IPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPI 482


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,980,913
Number of Sequences: 37866
Number of extensions: 909542
Number of successful extensions: 2624
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2378
Number of HSP's gapped (non-prelim): 92
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.