Search of human proteins with 4502835

Search of human proteins with 4502835

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
[Homo sapiens]
         (458 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   925   0.0  
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   612   e-175
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   473   e-133
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    421   e-118
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   417   e-117
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   416   e-116
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     382   e-106
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   374   e-104
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   371   e-103
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   360   1e-99
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   316   3e-86
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   300   1e-81
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   288   9e-78
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   287   1e-77
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   283   2e-76
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   276   2e-74
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   246   4e-65
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   216   3e-56
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   215   6e-56
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   201   1e-51
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              194   2e-49
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   171   1e-42
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   162   8e-40
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   155   7e-38
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              130   3e-30
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...    92   1e-18
gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]    74   4e-13
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...    72   8e-13
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...    72   8e-13
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p...    72   8e-13

>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  925 bits (2391), Expect = 0.0
 Identities = 458/458 (100%), Positives = 458/458 (100%)

Query: 1   MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGL 60
           MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGL
Sbjct: 1   MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGL 60

Query: 61  KISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFEN 120
           KISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFEN
Sbjct: 61  KISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFEN 120

Query: 121 ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTM 180
           ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTM
Sbjct: 121 ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTM 180

Query: 181 VDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFL 240
           VDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFL
Sbjct: 181 VDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFL 240

Query: 241 IIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYL 300
           IIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYL
Sbjct: 241 IIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYL 300

Query: 301 LFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPE 360
           LFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPE
Sbjct: 301 LFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPE 360

Query: 361 KEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWK 420
           KEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWK
Sbjct: 361 KEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWK 420

Query: 421 FVAQVLDRIFLWLFLIVSVTGSVLIFTPALKMWLHSYH 458
           FVAQVLDRIFLWLFLIVSVTGSVLIFTPALKMWLHSYH
Sbjct: 421 FVAQVLDRIFLWLFLIVSVTGSVLIFTPALKMWLHSYH 458


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  612 bits (1577), Expect = e-175
 Identities = 295/431 (68%), Positives = 354/431 (82%), Gaps = 17/431 (3%)

Query: 23  NSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLK 82
           +SIA++ED+LL+ LFQ Y++WVRPV H ND IK+ FGL ISQLVDVDEKNQLMTTNVWLK
Sbjct: 41  SSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLK 100

Query: 83  QEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVV 142
           QEW D KLRWNPDDYGGI  I+VPS+S+W PDIVLF+NADGRFEG+  TK +++ NGTV 
Sbjct: 101 QEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGT-STKTVIRYNGTVT 159

Query: 143 WTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWE 202
           WTPPA+YKSSCT+DVTFFPFD QNCSMKFGSWTYDG+ VD+IL +++VD++DFFDNGEWE
Sbjct: 160 WTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWE 219

Query: 203 ILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG 262
           I++A G KGNR D    YP++TYSFV++RLPLFYTLFLIIPC+GLSFLTVLVFYLPS+EG
Sbjct: 220 IVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEG 279

Query: 263 EKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHH 322
           EK+ L TSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYL+F MIFVTLSI+VTVF IN+HH
Sbjct: 280 EKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHH 339

Query: 323 RSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLS 382
           RSSST++ MAP V+++FL  LPKLLCM+ HVDRY                  +K++ +  
Sbjct: 340 RSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRY----------------FTQKEETESG 383

Query: 383 DGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGS 442
            G K     LE A DSIRYI+RH+ KE+ + +VV+DWKF+AQVLDR+FLW FL VS+ GS
Sbjct: 384 SGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGS 443

Query: 443 VLIFTPALKMW 453
           + +F P +  W
Sbjct: 444 LGLFVPVIYKW 454


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  473 bits (1216), Expect = e-133
 Identities = 248/470 (52%), Positives = 320/470 (68%), Gaps = 46/470 (9%)

Query: 24  SIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQ 83
           S  E ED L +HLF+GY +W RPV +++D + V FGL I+QL+DVDEKNQ+MTTNVWLKQ
Sbjct: 54  SHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQ 113

Query: 84  EWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVW 143
           EW+D+KLRWNP D+G I S++VPSE +W+PDIVL+ NADG F  + MTK  + S GTV W
Sbjct: 114 EWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHW 173

Query: 144 TPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEI 203
            PPA YKSSC++DVTFFPFD+QNC MKFGSWTYD   +DL  + + VD KD++++GEW I
Sbjct: 174 VPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAI 233

Query: 204 LNAKGMKGNRRDGVYS--YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE 261
           +NA G   +++    +  YP +TY+FV+RRLPLFYT+ LIIPCL +S LTVLVFYLPSD 
Sbjct: 234 VNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDC 293

Query: 262 GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVH 321
           GEK++L  SVL+SLTVFLL+I EIIPS+S VIPLIGEYLLF MIFVTLSI++TVFV+NVH
Sbjct: 294 GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVH 353

Query: 322 HRSSSTYHPMAPWVKRLFLQKLPKLLCMKD--------HVDRY----------SSPEKEE 363
           HRS ST H M  WV+   L  +P+ L M          H  R           S+ + EE
Sbjct: 354 HRSPST-HTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEE 412

Query: 364 SQPVVK--------GKVLEK-----------------KKQKQLSDGEKVLVAFLEKAADS 398
            + VV+        G V                    K +  L +GE +L   ++KA + 
Sbjct: 413 REVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEG 472

Query: 399 IRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTP 448
           + YI+ H++ E   S V +DWK+VA V+DRIFLWLF+IV   G++ +F P
Sbjct: 473 VHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLP 522


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  421 bits (1083), Expect = e-118
 Identities = 215/455 (47%), Positives = 303/455 (66%), Gaps = 34/455 (7%)

Query: 29  EDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDH 88
           E+ L   LF  Y +++RPV + +D + V+F + I+QL +VDE NQ+M TN+WL+  W D+
Sbjct: 34  EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDY 93

Query: 89  KLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPAS 148
           KLRW+P +Y GI +++VP++ +W PDIVL+ NA G F+    TK ++K NG + WTPPA 
Sbjct: 94  KLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAI 153

Query: 149 YKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKG 208
           +KSSC MD+TFFPFD QNCS+KFGSWTYD   +DL++I   VD  DF++N EWEI++A G
Sbjct: 154 FKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASG 213

Query: 209 MKGNRRDGVYS--YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLS 266
            K + +       Y  ITYSF +RRLP+FYT+ LIIPCL +SFLTVLVFYLPSD GEK++
Sbjct: 214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVT 273

Query: 267 LSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSS 326
           L  SVL+SLTVFLLVI E IPS+S V+PL+GEYLLF MIFVTLSI+VTVFV+N+H+R+ +
Sbjct: 274 LCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT 333

Query: 327 TYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEE-----SQPVVKGKVLEK------ 375
           T H M  WVK +FL+ LP++L M+  +D+      +      ++   KGK+         
Sbjct: 334 T-HTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHL 392

Query: 376 ------KKQKQLSDGEKVL--------------VAFLEKAADSIRYISRHVKKEHFISQV 415
                  K  +L+  ++ L                 +E   +S+++I+ ++K  +   +V
Sbjct: 393 KECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEV 452

Query: 416 VQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPAL 450
             DWK+VA V+DR+FLW+F+IV V G+  +F   L
Sbjct: 453 EDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPL 487


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  417 bits (1073), Expect = e-117
 Identities = 208/347 (59%), Positives = 268/347 (77%), Gaps = 4/347 (1%)

Query: 6   MLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQL 65
           +L+L+  G+   A++   + A  E+ LL+ LF GY KW RPV + +D + V FGL I+QL
Sbjct: 15  LLLLLGTGL-LRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQL 73

Query: 66  VDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRF 125
           +DVDEKNQ+MTTNVW+KQEW D+KLRW+P DY  + SI++PSE +W PDIVL+ NADG F
Sbjct: 74  IDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDF 133

Query: 126 EGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLIL 185
             + +TK  +  +G V WTPPA YKSSC++DVTFFPFD+QNC+MKFGSWTYD   +DL+ 
Sbjct: 134 AVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVN 193

Query: 186 INENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS--YPFITYSFVLRRLPLFYTLFLIIP 243
           ++  VD+ DF+++GEW I++A G    R+    +  YP ITY+FV+RRLPLFYT+ LIIP
Sbjct: 194 MHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIP 253

Query: 244 CLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFI 303
           CL +S LTVLVFYLPS+ GEK++L  SVL+SLTVFLL+I EIIPS+S VIPLIGEYLLF 
Sbjct: 254 CLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFT 313

Query: 304 MIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK 350
           MIFVTLSI++TVFV+NVHHRS  T H M  WV+R+FL  +P+LL MK
Sbjct: 314 MIFVTLSIVITVFVLNVHHRSPRT-HTMPTWVRRVFLDIVPRLLLMK 359



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 27/57 (47%), Positives = 41/57 (71%)

Query: 392 LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTP 448
           L +A + ++YI+ H+K E     V +DWK+VA V+DRIFLW+F+IV + G+V +F P
Sbjct: 564 LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLP 620


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  416 bits (1069), Expect = e-116
 Identities = 221/492 (44%), Positives = 308/492 (62%), Gaps = 50/492 (10%)

Query: 3   PDFMLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKI 62
           P  +L+L++L +   A       +E E  L   LF+ Y + +RPV + +D + ++F + +
Sbjct: 14  PPRLLLLLLLSLLPVARA-----SEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSM 68

Query: 63  SQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENAD 122
           SQLV VDE NQ+M TN+WLKQ W D+KL+WNP DYGG   ++VP++ +W PDIVL+ NA 
Sbjct: 69  SQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAV 128

Query: 123 GRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVD 182
           G F+    TK ++K  G V W PPA +KSSC +DVT+FPFD QNC+MKFGSW+YD   +D
Sbjct: 129 GDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKID 188

Query: 183 LILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS--YPFITYSFVLRRLPLFYTLFL 240
           L+LI  +++ KD++++GEW I+ A G K + +       YP ITYS  +RRLPLFYT+ L
Sbjct: 189 LVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINL 248

Query: 241 IIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYL 300
           IIPCL +SFLTVLVFYLPSD GEK++L  SVL+SLTVFLLVI E IPS+S VIPLIGEYL
Sbjct: 249 IIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYL 308

Query: 301 LFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPE 360
           LF MIFVTLSI++TVFV+NVH+R+ +T H M  WVK +FL  LP+++ M        + +
Sbjct: 309 LFTMIFVTLSIVITVFVLNVHYRTPTT-HTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQ 367

Query: 361 K-----------------------EESQPVVKGKV----------------LEKKKQKQL 381
           K                       +E  P   G                  L +    + 
Sbjct: 368 KPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSES 427

Query: 382 SDGEKVLVAF---LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVS 438
            D    L A    +++A  S++YI+ ++K ++   ++  DWK+VA V+DRIFLW+F +V 
Sbjct: 428 VDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVC 487

Query: 439 VTGSVLIFTPAL 450
           + G+  +F   L
Sbjct: 488 ILGTAGLFLQPL 499


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  382 bits (982), Expect = e-106
 Identities = 200/464 (43%), Positives = 286/464 (61%), Gaps = 42/464 (9%)

Query: 25  IAENEDALLRHLFQG--YQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLK 82
           +A  E+ L+  L     Y   +RP   S+  I +   L ++QL+ V+E+ Q+MTTNVWLK
Sbjct: 23  VANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWLK 82

Query: 83  QEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVV 142
           QEWTD++L WN   Y G++ +++P++ +WLPDIVL+ NADG +E S+ T +IV+SNG+V+
Sbjct: 83  QEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSVL 142

Query: 143 WTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWE 202
           W PPA YKS+C ++V +FPFD+QNC++KF SWTYD T +D++L+       DF  +GEW+
Sbjct: 143 WLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTASMDDFTPSGEWD 202

Query: 203 ILNAKGMKG-NRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE 261
           I+   G +  N +D   SY  +TY F+++R PLFYT+ LIIPC+  + L +LVFYLPSD 
Sbjct: 203 IVALPGRRTVNPQDP--SYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPSDC 260

Query: 262 GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVH 321
           GEK++L  SVL++LT FLL+I +I+P +S  +PLIG+YL+F M+ VT SI+ +V V+NVH
Sbjct: 261 GEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVH 320

Query: 322 HRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEK---EESQPVVKGKVLEKKKQ 378
           HRS ST H MAPWVKR FL KLP  L MK      SSP +        V K +       
Sbjct: 321 HRSPST-HTMAPWVKRCFLHKLPTFLFMK-RPGPDSSPARAFPPSKSCVTKPEATATSTS 378

Query: 379 KQLSDGEKVLVAFLEKAA--------------------------------DSIRYISRHV 406
                G  +       AA                                + + +I++H+
Sbjct: 379 PSNFYGNSMYFVNPASAASKSPAGSTPVAIPRDFWLRSSGRFRQDVQEALEGVSFIAQHM 438

Query: 407 KKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPAL 450
           K +     VV+DWK+VA V+DR+FLW+F+ V V G+V +F P L
Sbjct: 439 KNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPL 482


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  374 bits (961), Expect = e-104
 Identities = 192/434 (44%), Positives = 279/434 (64%), Gaps = 13/434 (2%)

Query: 26  AENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEW 85
           +E+E  L+  LF+ Y   VRPV      ++V  GL++ QL++VDE NQ++TTNV LKQ+W
Sbjct: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQW 80

Query: 86  TDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTP 145
            D+ L+WNPDDYGG+  I +PSE +W PD+VL+ NADG F     TKV+++  G + WTP
Sbjct: 81  VDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTP 140

Query: 146 PASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILN 205
           PA +KS C + VT FPFD QNCSMK G+WTYDG++V +   ++  D  +F ++GEW I  
Sbjct: 141 PAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKE 200

Query: 206 AKGMKGNRRDGVYS------YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPS 259
           ++G K       YS      Y  ITY FV++RLPL++ + +IIPCL  SFLT LVFYLP+
Sbjct: 201 SRGWK---HSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPT 257

Query: 260 DEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVIN 319
           D GEK++LS SVL+SLTVFLLVI E+IPS+S  +PLIG+Y+LF M+FV  SII+TV VIN
Sbjct: 258 DSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVIN 317

Query: 320 VHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK--DHVDRYSSPEKEESQPVVKGKVLEKKK 377
            HHRS ST H M  WV+++F+  +P ++         R    +K  ++ +    +  K  
Sbjct: 318 THHRSPST-HVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPG 376

Query: 378 QKQLSDGEKVLV-AFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLI 436
              +     ++    ++ A + I+YI+  +K +   +    +WK+VA V+D I L +F++
Sbjct: 377 PPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFML 436

Query: 437 VSVTGSVLIFTPAL 450
           V + G++ +F   L
Sbjct: 437 VCIIGTLAVFAGRL 450


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  371 bits (952), Expect = e-103
 Identities = 190/479 (39%), Positives = 293/479 (61%), Gaps = 56/479 (11%)

Query: 27  ENEDALLRHLFQG--YQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQE 84
           + E+ L+ HL     Y K +RP  + ++ + V   + ++QL+ V E+ Q+MTTNVWL QE
Sbjct: 27  DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQE 86

Query: 85  WTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWT 144
           W D++L W P+++  +  +++PS+ +WLPD+VL+ NADG +E S  +  +V  +G++ W 
Sbjct: 87  WEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWL 146

Query: 145 PPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEIL 204
           PPA YKS+C ++V  FPFD+QNC+MKF SWTYD T +DL+L +E     DF  +GEW+I+
Sbjct: 147 PPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIV 206

Query: 205 NAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEK 264
              G +    D   +Y  ITY F++RR PLFYT+ LIIPC+ ++ L +LVFYLPSD GEK
Sbjct: 207 ALPGRRNENPDD-STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEK 265

Query: 265 LSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRS 324
           ++L  SVL++LTVFLL+I +I+P +S  +PL+G+YL+F M+ VT SI+ +V V+NVHHRS
Sbjct: 266 MTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRS 325

Query: 325 SSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQK----- 379
            +T H MAPWVK +FL+KLP LL M+        P    ++  ++ +  +++++      
Sbjct: 326 PTT-HTMAPWVKVVFLEKLPALLFMQ-------QPRHHCARQRLRLRRRQREREGAGALF 377

Query: 380 -QLSDGEKVLVAFLEKAA---------------------------------DSIRYISRH 405
            + + G      F+ +A+                                 D +R+I+ H
Sbjct: 378 FREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADH 437

Query: 406 VKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPAL------KMWLHSYH 458
           ++ E     V +DWK+VA V+DR+FLW+F+ V V G++ +F   L        +LHS H
Sbjct: 438 MRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDH 496


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  360 bits (925), Expect = 1e-99
 Identities = 192/459 (41%), Positives = 279/459 (60%), Gaps = 38/459 (8%)

Query: 26  AENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQ-- 83
           +E+E  L+  LF+ Y   VRPV      ++V  GL++ QL++VDE NQ++TTNV LKQ  
Sbjct: 21  SEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGD 80

Query: 84  -----------------------EWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFEN 120
                                  +W D+ L+WNPDDYGG+  I +PSE +W PD+VL+ N
Sbjct: 81  MVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNN 140

Query: 121 ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTM 180
           ADG F     TKV+++  G + WTPPA +KS C + VT FPFD QNCSMK G+WTYDG++
Sbjct: 141 ADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 200

Query: 181 VDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS------YPFITYSFVLRRLPL 234
           V +   ++  D  +F ++GEW I  ++G K       YS      Y  ITY FV++RLPL
Sbjct: 201 VAINPESDQPDLSNFMESGEWVIKESRGWK---HSVTYSCCPDTPYLDITYHFVMQRLPL 257

Query: 235 FYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIP 294
           ++ + +IIPCL  SFLT LVFYLP+D GEK++LS SVL+SLTVFLLVI E+IPS+S  +P
Sbjct: 258 YFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVP 317

Query: 295 LIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK--DH 352
           LIG+Y+LF M+FV  SII+TV VIN HHRS ST H M  WV+++F+  +P ++       
Sbjct: 318 LIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HVMPNWVRKVFIDTIPNIMFFSTMKR 376

Query: 353 VDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEKVLV-AFLEKAADSIRYISRHVKKEHF 411
             R    +K  ++ +    +  K     +     ++    ++ A + I+YI+  +K +  
Sbjct: 377 PSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQE 436

Query: 412 ISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPAL 450
            +    +WK+VA V+D I L +F++V + G++ +F   L
Sbjct: 437 SNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRL 475


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  316 bits (809), Expect = 3e-86
 Identities = 183/505 (36%), Positives = 283/505 (56%), Gaps = 71/505 (14%)

Query: 1   MLPDFMLVLI-VLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFG 59
           M P  +L+L+  LG P +   G    +E E  L   LF GY   VRP     D ++V  G
Sbjct: 1   MTPGALLMLLGALGAPLAP--GVRG-SEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVG 57

Query: 60  LKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFE 119
           L ++QL+ ++EK++ M+T V+L  EWTD++L W+P ++ GI S+++ +ES+WLPD+VL  
Sbjct: 58  LILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLN 117

Query: 120 NADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGT 179
           N DG F+ +L   V+V S+G+V W PP  Y+SSC++ VT+FPFD QNC+M F S++YD +
Sbjct: 118 NNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSS 177

Query: 180 MVDL-------------ILINENVDRKDFFDNGEWEILNAK------------GMKGNRR 214
            V L             I I+E      F +NG+WEI++              G +G R+
Sbjct: 178 EVSLQTGLGPDGQGHQEIHIHEGT----FIENGQWEIIHKPSRLIQPPGDPRGGREGQRQ 233

Query: 215 DGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVS 274
           +       + +  ++RR PLFY + +I PC+ ++ L + VFYLP D GEK+ LS   L++
Sbjct: 234 E-------VIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLT 286

Query: 275 LTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPW 334
           LTVFLL++ + +P +S  +P+I +YL+F M+ VT S+I++V V+N+HHRS  T H M  W
Sbjct: 287 LTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHT-HQMPLW 345

Query: 335 VKRLFLQKLPKLLCMK-DHVDRYSSPEKEESQPVVKG----------------------- 370
           V+++F+ KLP  L +K    +R   PE         G                       
Sbjct: 346 VRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPN 405

Query: 371 ---KVLEKKKQKQLSDGEKVLVAF---LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQ 424
                L     ++  DG    VA    L +   SI YI+R ++++     + +DW+FVA 
Sbjct: 406 RFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAM 465

Query: 425 VLDRIFLWLFLIVSVTGSVLIFTPA 449
           V+DR+FLW F+I +  G+++IF  A
Sbjct: 466 VVDRLFLWTFIIFTSVGTLVIFLDA 490


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  300 bits (769), Expect = 1e-81
 Identities = 168/466 (36%), Positives = 266/466 (57%), Gaps = 49/466 (10%)

Query: 29  EDALLRHLFQ--GYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWT 86
           E+ L+RHLFQ  GY K +RPV H  +++ V   L +S L+ + E  + +TTNVW++  WT
Sbjct: 25  EERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWT 84

Query: 87  DHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPP 146
           D++L+WN +++G I  +++P + +WLP+IVL  N DG F+ S    V+V   G V W PP
Sbjct: 85  DNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPP 144

Query: 147 ASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLIL---INEN---------VDRKD 194
           A ++SSC + VT+FPFD QNCS+KF S  Y    + L L     EN         +D + 
Sbjct: 145 AIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWIIIDPEG 204

Query: 195 FFDNGEWEILNAKGMKGNRRDGVYSYPF---ITYSFVLRRLPLFYTLFLIIPCLGLSFLT 251
           F +NGEWEI++               P    IT+  ++RR PLFY + +++PC+ +SF+ 
Sbjct: 205 FTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMV 264

Query: 252 VLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSI 311
            LVFYLP+D GEK S++ SVL++ +VFLL+I + +P++S  IPLIG++LLF M+ VT+ +
Sbjct: 265 NLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVV 324

Query: 312 IVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSP------------ 359
           ++ V V+N+H R+ ST H ++  VK+LFL+ LP+LL M    +   SP            
Sbjct: 325 VICVIVLNIHFRTPST-HVLSEGVKKLFLETLPELLHMSRPAEDGPSPGALVRRSSSLGY 383

Query: 360 -EKEESQPVVKGK---VLEKKKQK---------------QLSDGEKVLVAFLEKAADSIR 400
             K E   ++K +   + EK+ ++                    ++ L   L+ A D   
Sbjct: 384 ISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQAQQELFNELKPAVDGAN 443

Query: 401 YISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIF 446
           +I  H++ ++  ++    W  VA+ +DR+ L++   V V G+  IF
Sbjct: 444 FIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIF 489


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  288 bits (736), Expect = 9e-78
 Identities = 153/448 (34%), Positives = 251/448 (56%), Gaps = 33/448 (7%)

Query: 32  LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLR 91
           L   LF+ Y   +RPV  ++  + V   + +SQ+ D+DE+NQ++T  +W++Q W D  L 
Sbjct: 34  LFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLT 93

Query: 92  WNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKS 151
           W+ D Y G+ SI++PS+ +W PDIVL+  AD      + T V+++ +G + W  PA  KS
Sbjct: 94  WDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKS 153

Query: 152 SCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKG 211
           SC +DVT+FPFD Q C++ FGSWTY+G  VD+    ++ D  DF ++ EWE+     +K 
Sbjct: 154 SCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKN 213

Query: 212 NRRDGVYS--YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLST 269
               G  S  YP +T++ +L+R   FY + L+IPC+ +SFL  L FYLP+  GEK+SL  
Sbjct: 214 VISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGV 273

Query: 270 SVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYH 329
           ++L+++TVF L++ EI+P+S  V PLIG+Y +  M  +T S  +T+ V+N+H   +    
Sbjct: 274 TILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTALTIMVMNIHFCGAEA-R 331

Query: 330 PMAPWVKRLFLQKLPKLL--------CM-------KDHVDRYSSPEKEESQPVVKGKVLE 374
           P+  W + + L+ + ++L        C+       +DH+ +  S   E +    + K L 
Sbjct: 332 PVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLS 391

Query: 375 KKKQ-------------KQLSDGEKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKF 421
           +KK              K   + E     + +    +I YI++ +K     +    +WK 
Sbjct: 392 RKKDMNKRLKNDLGCQGKNPQEAESYCAQY-KVLTRNIEYIAKCLKDHKATNSKGSEWKK 450

Query: 422 VAQVLDRIFLWLFLIVSVTGSVLIFTPA 449
           VA+V+DR F+W+F I+    ++LI   A
Sbjct: 451 VAKVIDRFFMWIFFIMVFVMTILIIARA 478


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  287 bits (735), Expect = 1e-77
 Identities = 161/473 (34%), Positives = 249/473 (52%), Gaps = 56/473 (11%)

Query: 27  ENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWT 86
           E +  L + L + Y    RPV + +  + VYF L + Q++DVDEKNQ++TTN+WL+  WT
Sbjct: 24  EFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWT 83

Query: 87  DHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPP 146
           DH L+WN  +Y G+ +++ P   +W PDI+L+ +AD RF+ +  T V+V S+G   + PP
Sbjct: 84  DHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPP 143

Query: 147 ASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNA 206
             +KSSC +DV +FPFD Q+C +KFGSW+Y G  +DL +  +  D   +  NGEW+++  
Sbjct: 144 GIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM--QEADISGYIPNGEWDLV-- 199

Query: 207 KGMKGNRRDGVYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE 261
            G+ G R +  Y      YP +T++  +RR  L+Y L L+IPC+ +S L +LVF LP+D 
Sbjct: 200 -GIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADS 258

Query: 262 GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVH 321
           GEK+SL  +VL+SLTVF+L++ EI+P++S  +PLI +Y    MI V LS++VTV V+  H
Sbjct: 259 GEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYH 318

Query: 322 HRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKK--KQK 379
           H        M  W + + L      L MK   +    P  +  Q       +E       
Sbjct: 319 HHDPDG-GKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPP 377

Query: 380 QLSDGEKVLVAF-------------------------------------------LEKAA 396
             S+G  + + F                                           L K  
Sbjct: 378 PASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKIL 437

Query: 397 DSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPA 449
           + +RYI+   + +     V  +WKF A V+DR+ L  F + ++  ++ I   A
Sbjct: 438 EEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  283 bits (724), Expect = 2e-76
 Identities = 154/434 (35%), Positives = 241/434 (55%), Gaps = 31/434 (7%)

Query: 32  LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLR 91
           L R LF  Y   +RPV  ++ T+ V   + +SQ++D+DE+NQ++T  +W++QEWTD  LR
Sbjct: 33  LFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLR 92

Query: 92  WNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKS 151
           W+P+ YGG+ +I++PS  +W PDIVL+  AD +  GS  T V+++ +G V W  PA  +S
Sbjct: 93  WDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRS 152

Query: 152 SCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKG 211
           SC +DV  FPFD Q+C + FGSWT+ G  +D+          DF +N EW +L   GM  
Sbjct: 153 SCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVL---GMPA 209

Query: 212 NRRDGVYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLS 266
            RR   Y      YP +T++ +LRR    Y   L++PC+ +S L  L F+LP+D GEK+S
Sbjct: 210 RRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVS 269

Query: 267 LSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSS 326
           L  +VL++LTVF L++ E +P +  V PLIG+Y +  M  VT S  +T+ ++N+H+   S
Sbjct: 270 LGVTVLLALTVFQLLLAESMPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPS 328

Query: 327 TYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDG-- 384
              P+  W + L L  L + LC+           +E  +P  + +  E     Q  +G  
Sbjct: 329 V-RPVPAWARALLLGHLARGLCV-----------RERGEPCGQSRPPELSPSPQSPEGGA 376

Query: 385 --------EKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLI 436
                   E   +   E     +  I+   +      +  +DWK +A+V+DR FL +F  
Sbjct: 377 GPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFS 436

Query: 437 VSVTGSVLIFTPAL 450
           +++  S+L+   AL
Sbjct: 437 MALVMSLLVLVQAL 450


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  276 bits (707), Expect = 2e-74
 Identities = 156/477 (32%), Positives = 264/477 (55%), Gaps = 42/477 (8%)

Query: 8   VLIVLGIPSSATTGFNSIAENEDA-LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLV 66
           VL++LG+          + +NE+  L  HLF  Y    RPV    DT+ +   + ++ L+
Sbjct: 8   VLLLLGLLG------RGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLI 61

Query: 67  DVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFE 126
            ++EK + +TT+VW+  +W D++L ++ DD+GGI +++VPSE +WLP+IVL  N DG+F 
Sbjct: 62  SLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFG 121

Query: 127 GSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILI 186
            +    V+V   G+V W PPA Y+S C ++VT+FPFD QNCS+ F S TY+   V+    
Sbjct: 122 VAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFA 181

Query: 187 NEN---------VDRKDFFDNGEWEILNAKGMKGNRRDGVYSYP---FITYSFVLRRLPL 234
            +N         +D + + +NGEW I    G+      G    P    + YS ++RR PL
Sbjct: 182 VDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPL 241

Query: 235 FYTLFLIIPCLGLSFLTVLVFYLPSDE-GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVI 293
           FY + +I+PC+ +S L +L ++LP+   G+K ++S +VL++ TVFL +I + IP +S  +
Sbjct: 242 FYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSV 301

Query: 294 PLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCM--KD 351
           PL+G +L+F+M+  TL ++  V V+NV  R+ +T H M+P ++ + L+ LP+LL      
Sbjct: 302 PLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTT-HAMSPRLRHVLLELLPRLLGSPPPP 360

Query: 352 HVDRYSSPEKEESQPVV----KGKVLEKKKQKQLSDGEK-----VLVAFLEK-------- 394
              R +SP +  S   +    +  +L+K + + + +G++        AF +         
Sbjct: 361 EAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSLGAAAPEV 420

Query: 395 --AADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPA 449
               D++ +++   + +    + V DW  +   LD I  W  L++   GS LIF  A
Sbjct: 421 RCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSVGSSLIFLGA 477


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  246 bits (627), Expect = 4e-65
 Identities = 158/498 (31%), Positives = 272/498 (54%), Gaps = 64/498 (12%)

Query: 6   MLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQL 65
           +L+L++L +   A  G N     E+ LL  L Q Y   +RP    +D + V   L ++ L
Sbjct: 8   LLLLLLLAVCLGAQ-GRNQ----EERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNL 62

Query: 66  VDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRF 125
           + ++E+ + +TTNVW++ +W D++LRW+P DY G+  ++VPS  +W PDIVL  N DG F
Sbjct: 63  ISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVF 122

Query: 126 EGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLIL 185
           E +L   V+V  +G + W PPA ++S+C++ VT+FPFD QNCS+ F S TY    +DL L
Sbjct: 123 EVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL 182

Query: 186 INEN--------VDRKDFFDNGEWEILN--AKGMKGNRRDGVYS-YPFITYSFVLRRLPL 234
             E+        +D + F +NGEW I +  AK +         + +  + +  +++R PL
Sbjct: 183 SQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPL 242

Query: 235 FYTLFLIIPCLGLSFLTVLVFYLPSDE-GEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVI 293
           FY + +I PC+ +S + +L+ +LP+   G+K +++ +VL++ TVFL ++ + +P +S+ +
Sbjct: 243 FYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAV 302

Query: 294 PLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHV 353
           PLI +YL F+++   L ++  V V+NV  RS  T H MA  V+++FL+ LP+LL M  HV
Sbjct: 303 PLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHT-HSMARGVRKVFLRLLPQLLRM--HV 359

Query: 354 DRYSSPEKEESQP--------------------VVKGKVLEKKKQKQ---------LSDG 384
              +    +++Q                     + + ++L ++ Q+Q         L  G
Sbjct: 360 RPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKG 419

Query: 385 EKV----LVAFLEKAADSIR---------YISRHVKKEHFISQVVQDWKFVAQVLDRIFL 431
            ++        L++AA +I+           +RH ++ HF     ++W  V +VLDR+  
Sbjct: 420 PELGLSQFCGSLKQAAPAIQACVEACNLIACARH-QQSHF-DNGNEEWFLVGRVLDRVCF 477

Query: 432 WLFLIVSVTGSVLIFTPA 449
              L + + G+  IF  A
Sbjct: 478 LAMLSLFICGTAGIFLMA 495


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  216 bits (550), Expect = 3e-56
 Identities = 131/462 (28%), Positives = 235/462 (50%), Gaps = 27/462 (5%)

Query: 9   LIVLGIPSSATTGFNSIAEN--EDALLR---HLFQGYQKWVRPVLHSNDTIKVYFGLKIS 63
           L+ L +P+    G    + N    ALLR   +L   Y+K VRPV        V   + + 
Sbjct: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74

Query: 64  QLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADG 123
            +++VDEKNQ++TT +W +Q WTD  L+WNP+D+  I  + +P++S+W+PDI++ E  D 
Sbjct: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDV 134

Query: 124 RFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSW--TYDGTMV 181
             +   +  V ++  G V    P    ++C++D+  FPFD QNCS+ F SW  T     +
Sbjct: 135 G-KSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 182 DLILINENV--DRKDFFDNGEWEILNA-KGMKGNRRDGVYSYPFITYSFVLRRLPLFYTL 238
            L  + E V  DR  F + GEWE+L      +    +    Y  + +  V+RR PLFY +
Sbjct: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVV 253

Query: 239 FLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGE 298
            L++P + L  + ++ FYLP + GE++S   ++L+  +VFL+++ + +P+++   PLIG 
Sbjct: 254 SLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGV 313

Query: 299 YLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSS 358
           Y +  M  + +S+  T+F++ + H+      P+  W++ L L+++  LLC+++       
Sbjct: 314 YFVVCMALLVISLAETIFIVRLVHK-QDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRP 372

Query: 359 PEKEESQPVVKGKVL-------------EKKKQKQLSDGEKVLVAFLEKAA--DSIRYIS 403
           P   ++        +             EK  + + S       A L        +  I 
Sbjct: 373 PATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIR 432

Query: 404 RHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLI 445
           + ++K   I +V +DW  V  VLD++   ++L+  +  S+ +
Sbjct: 433 QFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITL 474


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  215 bits (548), Expect = 6e-56
 Identities = 126/438 (28%), Positives = 226/438 (51%), Gaps = 25/438 (5%)

Query: 31  ALLR---HLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTD 87
           ALLR   +L   Y+K VRPV        V   + +  +++VDEKNQ++TT +W +Q WTD
Sbjct: 18  ALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTD 77

Query: 88  HKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPA 147
             L+WNP+D+  I  + +P++S+W+PDI++ E  D   +   +  V ++  G V    P 
Sbjct: 78  EFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVG-KSPNIPYVYIRHQGEVQNYKPL 136

Query: 148 SYKSSCTMDVTFFPFDRQNCSMKFGSW--TYDGTMVDLILINENV--DRKDFFDNGEWEI 203
              ++C++D+  FPFD QNCS+ F SW  T     + L  + E V  DR  F + GEWE+
Sbjct: 137 QVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWEL 196

Query: 204 LNA-KGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG 262
           L      +    +    Y  + +  V+RR PLFY + L++P + L  + ++ FYLP + G
Sbjct: 197 LGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSG 256

Query: 263 EKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHH 322
           E++S   ++L+  +VFL+++ + +P+++   PLIG Y +  M  + +S+  T+F++ + H
Sbjct: 257 ERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVH 316

Query: 323 RSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVL--------- 373
           +      P+  W++ L L+++  LLC+++       P   ++        +         
Sbjct: 317 K-QDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGG 375

Query: 374 ----EKKKQKQLSDGEKVLVAFLEKAA--DSIRYISRHVKKEHFISQVVQDWKFVAQVLD 427
               EK  + + S       A L        +  I + ++K   I +V +DW  V  VLD
Sbjct: 376 PQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLD 435

Query: 428 RIFLWLFLIVSVTGSVLI 445
           ++   ++L+  +  S+ +
Sbjct: 436 KLLFHIYLLAVLAYSITL 453


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  201 bits (510), Expect = 1e-51
 Identities = 131/494 (26%), Positives = 236/494 (47%), Gaps = 59/494 (11%)

Query: 9   LIVLGIPSSATTGFNSIAEN--EDALLR---HLFQGYQKWVRPVLHSNDTIKVYFGLKIS 63
           L+ L +P+    G    + N    ALLR   +L   Y+K VRPV        V   + + 
Sbjct: 15  LLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVY 74

Query: 64  QLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADG 123
            +++VDEKNQ++TT +W +Q WTD  L+WNP+D+  I  + +P++S+W+PDI++ E  D 
Sbjct: 75  AILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDV 134

Query: 124 RFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSW--TYDGTMV 181
             +   +  V ++  G V    P    ++C++D+  FPFD QNCS+ F SW  T     +
Sbjct: 135 G-KSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINI 193

Query: 182 DLILINENV--DRKDFFDNGEWEILNA-KGMKGNRRDGVYSYPFITYSFVLRRLPLFYTL 238
            L  + E V  DR  F + GEWE+L      +    +    Y  + +  V+RR PLFY +
Sbjct: 194 SLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVV 253

Query: 239 FLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGE 298
            L++P + L  + ++ FYLP + GE++S   ++L+  +VFL+++ + +P+++   PLIG+
Sbjct: 254 SLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGK 313

Query: 299 --------------------------------YLLFIMIFVTLSIIVTVFVINVHHRSSS 326
                                           Y +  M  + +S+  T+F++ + H+   
Sbjct: 314 APPGSRAQSGEKPAPSHLLHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHK-QD 372

Query: 327 TYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVL------------- 373
              P+  W++ L L+++  LLC+++       P   ++        +             
Sbjct: 373 LQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDF 432

Query: 374 EKKKQKQLSDGEKVLVAFLEKAA--DSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFL 431
           EK  + + S       A L        +  I + ++K   I +V +DW  V  VLD++  
Sbjct: 433 EKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLF 492

Query: 432 WLFLIVSVTGSVLI 445
            ++L+  +  S+ +
Sbjct: 493 HIYLLAVLAYSITL 506


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  194 bits (492), Expect = 2e-49
 Identities = 122/379 (32%), Positives = 187/379 (49%), Gaps = 56/379 (14%)

Query: 121 ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTM 180
           AD RF+ +  T V+V S+G   + PP  +KSSC +DV +FPFD Q+C +KFGSW+Y G  
Sbjct: 28  ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWS 87

Query: 181 VDLILINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS-----YPFITYSFVLRRLPLF 235
           +DL +  +  D   +  NGEW+++   G+ G R +  Y      YP +T++  +RR  L+
Sbjct: 88  LDLQM--QEADISGYIPNGEWDLV---GIPGKRSERFYECCKEPYPDVTFTVTMRRRTLY 142

Query: 236 YTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPL 295
           Y L L+IPC+ +S L +LVF LP+D GEK+SL  +VL+SLTVF+L++ EI+P++S  +PL
Sbjct: 143 YGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPL 202

Query: 296 IGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDR 355
           I +Y    MI V LS++VTV V+  HH        M  W + + L      L MK   + 
Sbjct: 203 IAQYFASTMIIVGLSVVVTVIVLQYHHHDPDG-GKMPKWTRVILLNWCAWFLRMKRPGED 261

Query: 356 YSSPEKEESQPVVKGKVLEKK--KQKQLSDGEKVLVAF---------------------- 391
              P  +  Q       +E         S+G  + + F                      
Sbjct: 262 KVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMA 321

Query: 392 ---------------------LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIF 430
                                L K  + +RYI+   + +     V  +WKF A V+DR+ 
Sbjct: 322 CSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLC 381

Query: 431 LWLFLIVSVTGSVLIFTPA 449
           L  F + ++  ++ I   A
Sbjct: 382 LMAFSVFTIICTIGILMSA 400


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  171 bits (434), Expect = 1e-42
 Identities = 106/330 (32%), Positives = 168/330 (50%), Gaps = 15/330 (4%)

Query: 1   MLPDFMLVLIVLGIPSSATTGFNSIAENEDALLRHL----FQGYQKWVRPVLHSNDTIKV 56
           M P +  +L+  GI ++ T         +D+ L HL     Q Y K VRPV +      V
Sbjct: 6   MAPLWACILVAAGILATDTH------HPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTV 59

Query: 57  YFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIV 116
           Y  L +  ++DVD +NQ++ T+VW ++ W D  L WN   +  I  I +P  ++W PDI+
Sbjct: 60  YLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDII 119

Query: 117 LFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTY 176
           + E  D      L   V V S+GT+    P    S+C+++   FPFD QNCS+ F S  +
Sbjct: 120 INEFVDIERYPDL-PYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILH 178

Query: 177 DGTMVDLILIN--ENV--DRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRL 232
               VDL  +   E++  D+K F ++ EWE+L+        +     +  I ++ V+RR 
Sbjct: 179 TVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRH 238

Query: 233 PLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKV 292
           PL Y + L+IP + L  + +  FYLP +   ++   TSVLV  TVF + +   +P S   
Sbjct: 239 PLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGS 298

Query: 293 IPLIGEYLLFIMIFVTLSIIVTVFVINVHH 322
            PLIG +    M F+ LS+  ++ ++   H
Sbjct: 299 TPLIGHFFTICMAFLVLSLAKSIVLVKFLH 328


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  162 bits (409), Expect = 8e-40
 Identities = 111/408 (27%), Positives = 201/408 (49%), Gaps = 20/408 (4%)

Query: 41  QKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGI 100
           +K  RPV + +   +V     +S ++DV+E+  L+++ +WL+  W +  + WNP++  GI
Sbjct: 66  RKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGI 125

Query: 101 HSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFF 160
             + + +++LWLPDI + E  D       +T   V + G + +  P    S C +D+ +F
Sbjct: 126 TKMSMAAKNLWLPDIFIIELMDVDKTPKGLT-AYVSNEGRIRYKKPMKVDSICNLDIFYF 184

Query: 161 PFDRQNCSMKFGSWTY--DGTMVDL---ILINENVDRKDFFDNGEWEILNAKGMKGNRRD 215
           PFD+QNC++ F S+ Y  D  ++D+   +    +  R     +GEWE+L           
Sbjct: 185 PFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSR 244

Query: 216 GVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSL 275
           G   Y  I +   +RR P  Y + L++P   L  +  L FYLP   G ++    ++L+  
Sbjct: 245 GGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGY 304

Query: 276 TVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWV 335
            VFLL++ +++P+S    PLIG Y    +  +  S++ T+F+ ++ H +++   P+  W+
Sbjct: 305 NVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWL 362

Query: 336 KRLFLQ-KLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQKQLSDGEKVLVAFLEK 394
             L L    P   C        ++P+KE   P +    L   K+ ++S G+    A  E 
Sbjct: 363 HSLLLHCNSPGRCCP-------TAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAEL 415

Query: 395 AADS--IRYISRH-VKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSV 439
              S   R    H  +K+H +   +Q    +  +L R++L LF+  S+
Sbjct: 416 TGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYL-LFMASSI 462


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  155 bits (392), Expect = 7e-38
 Identities = 91/308 (29%), Positives = 155/308 (50%), Gaps = 14/308 (4%)

Query: 41  QKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGI 100
           +K  RP  + +   +V     +S ++ VD + QL+T+ +W+   W +  + WNP +  GI
Sbjct: 51  RKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGI 110

Query: 101 HSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFF 160
           + + V +E+LWLPDI + E+ D     S +T   + S G + +  P    S C +D+ +F
Sbjct: 111 NKLTVLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRVTSICNLDIFYF 169

Query: 161 PFDRQNCSMKFGSWTYDGTMVDLILIN--------ENVDRKDFFDNGEWEILNAKGMKGN 212
           PFD+QNC+  F S+ Y    VD +L+          +  RK     GEWE+L        
Sbjct: 170 PFDQQNCTFTFSSFLY---TVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPK 226

Query: 213 RRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVL 272
              G   Y  I +   +RR P  Y + L++P   L  +  L FYLP++   +     ++L
Sbjct: 227 MSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLL 286

Query: 273 VSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMA 332
           +   VFLL++ +++P+S    PLI  Y    +  + +S++ TVF+  + H +++   PM 
Sbjct: 287 LGYNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMP 344

Query: 333 PWVKRLFL 340
            W+  L L
Sbjct: 345 RWLHSLLL 352


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  130 bits (326), Expect = 3e-30
 Identities = 90/312 (28%), Positives = 142/312 (45%), Gaps = 54/312 (17%)

Query: 188 ENVDRKDFFDNGEWEILNAKGMKGNRRDGVYS-----YPFITYSFVLRRLPLFYTLFLII 242
           +  D   +  NGEW+++   G+ G R +  Y      YP +T++  +RR  L+Y L L+I
Sbjct: 2   QEADISGYIPNGEWDLV---GIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLI 58

Query: 243 PCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLF 302
           PC+ +S L +LVF LP+D GEK+SL  +VL+SLTVF+L++ EI+P++S  +PLI +Y   
Sbjct: 59  PCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAS 118

Query: 303 IMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKE 362
            MI V LS++VTV V+  HH        M  W + + L      L MK   +    P  +
Sbjct: 119 TMIIVGLSVVVTVIVLQYHHHDPDG-GKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQ 177

Query: 363 ESQPVVKGKVLEKK--KQKQLSDGEKVLVAF----------------------------- 391
             Q       +E         S+G  + + F                             
Sbjct: 178 HKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDE 237

Query: 392 --------------LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIV 437
                         L K  + +RYI+   + +     V  +WKF A V+DR+ L  F + 
Sbjct: 238 HLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVF 297

Query: 438 SVTGSVLIFTPA 449
           ++  ++ I   A
Sbjct: 298 TIICTIGILMSA 309


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 65/278 (23%), Positives = 129/278 (46%), Gaps = 8/278 (2%)

Query: 35  HLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNP 94
           +L  GY K++RP     + +++   L I+ +  + E N   T  ++L+Q W D +L +  
Sbjct: 43  NLTAGYNKFLRPNF-GGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101

Query: 95  DDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVK--SNGTVVWTPPASYKSS 152
           +    + +  V  E LW+PD  + E+         +   +++  SNGTV++    +   +
Sbjct: 102 NKSFTLDARLV--EFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVA 159

Query: 153 CTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILI--NENVDRKDFFDNGEWEILNAKGMK 210
           C MD++ +P D Q C ++  SW YDG  V+   +  N++V   +     ++ I     + 
Sbjct: 160 CNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLV 219

Query: 211 GNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDE-GEKLSLST 269
              +    +Y  +   F LRR  L++ L   +P   L  L+ + F++  D    +  +  
Sbjct: 220 TRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGV 279

Query: 270 SVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFV 307
           + ++S+T  ++     +P+++  I  I  YL     FV
Sbjct: 280 TTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFV 317


>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
          Length = 412

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 66/270 (24%), Positives = 120/270 (44%), Gaps = 21/270 (7%)

Query: 62  ISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFEN- 120
           +S + +VD     M++ + L+  W D +L WN   +   H+I +P ESLW P + + E  
Sbjct: 68  VSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRLTILEAL 126

Query: 121 -ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGT 179
             D R +     +  V  +G V      + +++C  ++  FP D  NCS+ F  +    T
Sbjct: 127 WVDWRDQSP---QARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSF--YALSNT 181

Query: 180 MVDLI----LINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLF 235
            ++L     ++NE V  K      E+ + + K     ++      P    +  L+   L 
Sbjct: 182 AMELEFQAHVVNEIVSVKR-----EYVVYDLKTQVPPQQ----LVPCFQVTLRLKNTALK 232

Query: 236 YTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPL 295
             + L++P   L    V    LP    E++    ++L+S  V    + + +PSSS   PL
Sbjct: 233 SIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPL 292

Query: 296 IGEYLLFIMIFVTLSIIVTVFVINVHHRSS 325
           +  Y   +++ + LS I TV +  +  R +
Sbjct: 293 LIYYFTILLLLLFLSTIETVLLAGLLARGN 322


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 51/235 (21%), Positives = 106/235 (45%), Gaps = 14/235 (5%)

Query: 32  LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLR 91
           +L  L  GY   +RP L  + T +V+  + ++    V + +   T +V+ +Q+W D +L+
Sbjct: 45  ILDRLLDGYDNRLRPGLGDSIT-EVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLK 103

Query: 92  WNPDDYGGIHSIKVPS---ESLWLPDIVLFENADGRFEGSLMTKVI--VKSNGTVVWTPP 146
           +     G ++ +++ +     +W PD               M   +  ++ +GT+++T  
Sbjct: 104 FK----GPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMR 159

Query: 147 ASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNG----EWE 202
            + ++ C M +  FP D  +C +KFGS+ Y  + V  I      D      +G    +++
Sbjct: 160 LTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYD 219

Query: 203 ILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYL 257
           +L     K   +     Y  +T  F L+R   ++ +   +PC+    L+ + F+L
Sbjct: 220 LLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWL 274


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 51/235 (21%), Positives = 106/235 (45%), Gaps = 14/235 (5%)

Query: 32  LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHKLR 91
           +L  L  GY   +RP L  + T +V+  + ++    V + +   T +V+ +Q+W D +L+
Sbjct: 45  ILDRLLDGYDNRLRPGLGDSIT-EVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLK 103

Query: 92  WNPDDYGGIHSIKVPS---ESLWLPDIVLFENADGRFEGSLMTKVI--VKSNGTVVWTPP 146
           +     G ++ +++ +     +W PD               M   +  ++ +GT+++T  
Sbjct: 104 FK----GPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMR 159

Query: 147 ASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNG----EWE 202
            + ++ C M +  FP D  +C +KFGS+ Y  + V  I      D      +G    +++
Sbjct: 160 LTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYD 219

Query: 203 ILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYL 257
           +L     K   +     Y  +T  F L+R   ++ +   +PC+    L+ + F+L
Sbjct: 220 LLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWL 274


>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
           precursor [Homo sapiens]
          Length = 474

 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 66/329 (20%), Positives = 144/329 (43%), Gaps = 36/329 (10%)

Query: 6   MLVLIVLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQL 65
           M+ ++     ++  +  + + E  D LL+    GY   +RP       + V   + ++ +
Sbjct: 18  MITMVCCAHSTNEPSNMSYVKETVDRLLK----GYDIRLRPDF-GGPPVDVGMRIDVASI 72

Query: 66  VDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRF 125
             V E N   T  ++ +Q W D +L ++          +V ++ LW+PD     +     
Sbjct: 73  DMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRV-ADQLWVPDTYFLNDKKSFV 131

Query: 126 EGSLMTKVIVK--SNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDL 183
            G  +   +++   +GTV++    +  ++C MD+  +P D QNC+++  S+ Y       
Sbjct: 132 HGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGY------- 184

Query: 184 ILINENVDRKDFFDNG--------------EWEILNAKGMKGNRRDGVYSYPFITYSFVL 229
                  D  +F+ NG              ++ I++ K +         +YP ++ SF L
Sbjct: 185 -----TTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRL 239

Query: 230 RRLPLFYTLFLIIPCLGLSFLTVLVFYLPSD-EGEKLSLSTSVLVSLTVFLLVIEEIIPS 288
           +R   ++ L   +P   ++ L+ + F++  D    +++L  + ++++T     + E +P 
Sbjct: 240 KRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLP- 298

Query: 289 SSKVIPLIGEYLLFIMIFVTLSIIVTVFV 317
               +  I  YL+   +FV L+++   FV
Sbjct: 299 KIPYVKAIDIYLMGCFVFVFLALLEYAFV 327


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,871,531
Number of Sequences: 37866
Number of extensions: 727092
Number of successful extensions: 2719
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2525
Number of HSP's gapped (non-prelim): 91
length of query: 458
length of database: 18,247,518
effective HSP length: 106
effective length of query: 352
effective length of database: 14,233,722
effective search space: 5010270144
effective search space used: 5010270144
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.