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Search of human proteins with 4502819
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
(590 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens] 1187 0.0
gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens] 528 e-150
gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens] 486 e-137
gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens] 408 e-114
gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens] 408 e-114
gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens] 408 e-114
gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens] 408 e-114
gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens] 408 e-114
gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens] 408 e-114
gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens] 408 e-114
gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens] 408 e-114
gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens] 291 1e-78
gi|149158709 histamine receptor H1 [Homo sapiens] 182 6e-46
gi|149158706 histamine receptor H1 [Homo sapiens] 182 6e-46
gi|149158704 histamine receptor H1 [Homo sapiens] 182 6e-46
gi|4504491 histamine receptor H1 [Homo sapiens] 182 6e-46
gi|194018562 histamine receptor H3 [Homo sapiens] 157 3e-38
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 138 1e-32
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 138 2e-32
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 135 8e-32
gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo sa... 134 2e-31
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 132 7e-31
gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens] 131 2e-30
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 128 1e-29
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 126 5e-29
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 125 1e-28
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 125 1e-28
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 125 1e-28
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 125 1e-28
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 125 1e-28
>gi|4502819 cholinergic receptor, muscarinic 3 [Homo sapiens]
Length = 590
Score = 1187 bits (3072), Expect = 0.0
Identities = 590/590 (100%), Positives = 590/590 (100%)
Query: 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL 60
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
Sbjct: 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL 60
Query: 61 GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI 120
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
Sbjct: 61 GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI 120
Query: 121 SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR 180
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
Sbjct: 121 SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR 180
Query: 181 TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF 240
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
Sbjct: 181 TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF 240
Query: 241 YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM 300
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
Sbjct: 241 YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM 300
Query: 301 KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE 360
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
Sbjct: 301 KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE 360
Query: 361 TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF 420
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
Sbjct: 361 TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF 420
Query: 421 PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR 480
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
Sbjct: 421 PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR 480
Query: 481 MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN 540
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
Sbjct: 481 MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN 540
Query: 541 PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 590
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
Sbjct: 541 PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 590
>gi|7108336 cholinergic receptor, muscarinic 5 [Homo sapiens]
Length = 532
Score = 528 bits (1359), Expect = e-150
Identities = 288/545 (52%), Positives = 358/545 (65%), Gaps = 37/545 (6%)
Query: 48 NFSSPDGT--TDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNY 105
N ++ +GT PL H +W+V+ IA +T +++L+TI+GN+LV++SFKVN QLKTVNNY
Sbjct: 8 NATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNY 67
Query: 106 FLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFD 165
+LLSLACADLIIG+ SMNL+TTYI+M RWALG+LACDLWLA+DYVASNASVMNLLVISFD
Sbjct: 68 YLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFD 127
Query: 166 RYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQF 225
RYFSITRPLTYRAKRT KRAG+MIGLAW+ISF+LWAPAIL WQY VGKRTVP EC IQF
Sbjct: 128 RYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQF 187
Query: 226 LSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASG--TEAETENFVHP 283
LSEPTITFGTAIAAFY+PV++MTILY RIY+ETEKRTK+LA LQ S T+AE H
Sbjct: 188 LSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAH- 246
Query: 284 TGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAA 343
RSC + + N+ W +++ ++ + Q S +W +
Sbjct: 247 RALFRSCLRCPRPTLAQRERNQAS------WSSSRRSTSTTGKPSQATGPSANWAKAEQL 300
Query: 344 ASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLER 403
+ + SS++ED T + +V K G + P EE + E
Sbjct: 301 TTCSSYPSSEDED-KPATDPVLQVVYKSQGKES---------------PGEEFSAEETEE 344
Query: 404 KADKLQAQKSVDDGGSF---------PKSFSKLPIQLESAVDTAKTSDVNSSVGK-STAT 453
K + +KS D ++ PKS + + V + N+ K
Sbjct: 345 TFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMP 404
Query: 454 LPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLV 513
P + K Q+TKRKR+ LVKE+KAAQTLSAILLAFIITWTPYNIMVLV
Sbjct: 405 CPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLV 464
Query: 514 NTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQY 573
+TFCD C+P T W+LGYWLCY+NSTVNP+CYALCN+TFR TFKMLLLC+ KKK ++ Y
Sbjct: 465 STFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLY 524
Query: 574 QQRQS 578
Q S
Sbjct: 525 WQGNS 529
>gi|37622910 cholinergic receptor, muscarinic 1 [Homo sapiens]
Length = 460
Score = 486 bits (1252), Expect = e-137
Identities = 268/526 (50%), Positives = 325/526 (61%), Gaps = 97/526 (18%)
Query: 51 SPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSL 110
SP+ T P G WQV FI TG+L+L T+ GN+LV++SFKVN +LKTVNNYFLLSL
Sbjct: 10 SPNITVLAP--GKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSL 67
Query: 111 ACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSI 170
ACADLIIG SMNL+TTY++M WALG LACDLWLA+DYVASNASVMNLL+ISFDRYFS+
Sbjct: 68 ACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSV 127
Query: 171 TRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPT 230
TRPL+YRAKRT +RA +MIGLAW++SFVLWAPAILFWQY VG+RTV G+C+IQFLS+P
Sbjct: 128 TRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPI 187
Query: 231 ITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSC 290
ITFGTA+AAFY+PVT+M LYWRIY+ETE R +ELA LQ S T P S
Sbjct: 188 ITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSET---------PGKGGGSS 238
Query: 291 SSYELQQQSMKRSNRRKYGRC------HFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAA 344
SS E Q + S GRC SWK E+ +
Sbjct: 239 SSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDE---------------G 283
Query: 345 SLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERK 404
S+E+ SS+ E+ GSE +V+K+P MVD E +
Sbjct: 284 SMESLTSSEGEEPGSE------VVIKMP-------------------------MVDPEAQ 312
Query: 405 ADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLA 464
A Q +S +T P
Sbjct: 313 APTKQPPRS----------------------------------SPNTVKRPTKKGRDRAG 338
Query: 465 KRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKT 524
K + + Q+ KRK SLVKEKKAA+TLSAILLAFI+TWTPYNIMVLV+TFC C+P+T
Sbjct: 339 KGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPET 398
Query: 525 FWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRK 570
W LGYWLCY+NST+NP+CYALCNK FR TF++LLLC+ DK++ RK
Sbjct: 399 LWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRK 444
>gi|4502817 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 408 bits (1049), Expect = e-114
Identities = 223/499 (44%), Positives = 295/499 (59%), Gaps = 59/499 (11%)
Query: 63 HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122
+ ++VVFI + G L+LVTIIGNILV+VS KVN+ L+TVNNYFL SLACADLIIGV SM
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182
NL+T Y ++ W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY KRTT
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242
K AG+MI AWV+SF+LWAPAILFWQ+ VG RTV GEC+IQF S +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
Query: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
PV IMT+LYW I + ++ R K ++ P + S +Q + +K
Sbjct: 198 PVIIMTVLYWHISRASKSRIK--------------KDKKEPVANQDPVSPSLVQGRIVKP 243
Query: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362
+N PSS+ + + + D EN +E++ +++
Sbjct: 244 NNNN--------------MPSSDDGLEHNKIQNGKAPRDPVT--ENCVQGEEKESSNDST 287
Query: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422
++ ++ + D+ +E L D+ Q + G PK
Sbjct: 288 SVSAVASNM--------------RDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPK 333
Query: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482
S +S T T +V S G++ K+ +A++ T+ K+ S
Sbjct: 334 S--------DSCTPTNTTVEVVGSSGQNG-----DEKQNIVARKIVKMTKQPAKKKPPPS 380
Query: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPV 542
+EKK +T+ AILLAFIITW PYN+MVL+NTFC CIP T W +GYWLCYINST+NP
Sbjct: 381 --REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPA 438
Query: 543 CYALCNKTFRTTFKMLLLC 561
CYALCN TF+ TFK LL+C
Sbjct: 439 CYALCNATFKKTFKHLLMC 457
>gi|54792117 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 408 bits (1049), Expect = e-114
Identities = 223/499 (44%), Positives = 295/499 (59%), Gaps = 59/499 (11%)
Query: 63 HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122
+ ++VVFI + G L+LVTIIGNILV+VS KVN+ L+TVNNYFL SLACADLIIGV SM
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182
NL+T Y ++ W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY KRTT
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242
K AG+MI AWV+SF+LWAPAILFWQ+ VG RTV GEC+IQF S +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
Query: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
PV IMT+LYW I + ++ R K ++ P + S +Q + +K
Sbjct: 198 PVIIMTVLYWHISRASKSRIK--------------KDKKEPVANQDPVSPSLVQGRIVKP 243
Query: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362
+N PSS+ + + + D EN +E++ +++
Sbjct: 244 NNNN--------------MPSSDDGLEHNKIQNGKAPRDPVT--ENCVQGEEKESSNDST 287
Query: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422
++ ++ + D+ +E L D+ Q + G PK
Sbjct: 288 SVSAVASNM--------------RDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPK 333
Query: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482
S +S T T +V S G++ K+ +A++ T+ K+ S
Sbjct: 334 S--------DSCTPTNTTVEVVGSSGQNG-----DEKQNIVARKIVKMTKQPAKKKPPPS 380
Query: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPV 542
+EKK +T+ AILLAFIITW PYN+MVL+NTFC CIP T W +GYWLCYINST+NP
Sbjct: 381 --REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPA 438
Query: 543 CYALCNKTFRTTFKMLLLC 561
CYALCN TF+ TFK LL+C
Sbjct: 439 CYALCNATFKKTFKHLLMC 457
>gi|54792115 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 408 bits (1049), Expect = e-114
Identities = 223/499 (44%), Positives = 295/499 (59%), Gaps = 59/499 (11%)
Query: 63 HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122
+ ++VVFI + G L+LVTIIGNILV+VS KVN+ L+TVNNYFL SLACADLIIGV SM
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182
NL+T Y ++ W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY KRTT
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242
K AG+MI AWV+SF+LWAPAILFWQ+ VG RTV GEC+IQF S +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
Query: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
PV IMT+LYW I + ++ R K ++ P + S +Q + +K
Sbjct: 198 PVIIMTVLYWHISRASKSRIK--------------KDKKEPVANQDPVSPSLVQGRIVKP 243
Query: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362
+N PSS+ + + + D EN +E++ +++
Sbjct: 244 NNNN--------------MPSSDDGLEHNKIQNGKAPRDPVT--ENCVQGEEKESSNDST 287
Query: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422
++ ++ + D+ +E L D+ Q + G PK
Sbjct: 288 SVSAVASNM--------------RDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPK 333
Query: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482
S +S T T +V S G++ K+ +A++ T+ K+ S
Sbjct: 334 S--------DSCTPTNTTVEVVGSSGQNG-----DEKQNIVARKIVKMTKQPAKKKPPPS 380
Query: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPV 542
+EKK +T+ AILLAFIITW PYN+MVL+NTFC CIP T W +GYWLCYINST+NP
Sbjct: 381 --REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPA 438
Query: 543 CYALCNKTFRTTFKMLLLC 561
CYALCN TF+ TFK LL+C
Sbjct: 439 CYALCNATFKKTFKHLLMC 457
>gi|54792113 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 408 bits (1049), Expect = e-114
Identities = 223/499 (44%), Positives = 295/499 (59%), Gaps = 59/499 (11%)
Query: 63 HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122
+ ++VVFI + G L+LVTIIGNILV+VS KVN+ L+TVNNYFL SLACADLIIGV SM
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182
NL+T Y ++ W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY KRTT
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242
K AG+MI AWV+SF+LWAPAILFWQ+ VG RTV GEC+IQF S +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
Query: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
PV IMT+LYW I + ++ R K ++ P + S +Q + +K
Sbjct: 198 PVIIMTVLYWHISRASKSRIK--------------KDKKEPVANQDPVSPSLVQGRIVKP 243
Query: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362
+N PSS+ + + + D EN +E++ +++
Sbjct: 244 NNNN--------------MPSSDDGLEHNKIQNGKAPRDPVT--ENCVQGEEKESSNDST 287
Query: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422
++ ++ + D+ +E L D+ Q + G PK
Sbjct: 288 SVSAVASNM--------------RDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPK 333
Query: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482
S +S T T +V S G++ K+ +A++ T+ K+ S
Sbjct: 334 S--------DSCTPTNTTVEVVGSSGQNG-----DEKQNIVARKIVKMTKQPAKKKPPPS 380
Query: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPV 542
+EKK +T+ AILLAFIITW PYN+MVL+NTFC CIP T W +GYWLCYINST+NP
Sbjct: 381 --REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPA 438
Query: 543 CYALCNKTFRTTFKMLLLC 561
CYALCN TF+ TFK LL+C
Sbjct: 439 CYALCNATFKKTFKHLLMC 457
>gi|54792111 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 408 bits (1049), Expect = e-114
Identities = 223/499 (44%), Positives = 295/499 (59%), Gaps = 59/499 (11%)
Query: 63 HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122
+ ++VVFI + G L+LVTIIGNILV+VS KVN+ L+TVNNYFL SLACADLIIGV SM
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182
NL+T Y ++ W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY KRTT
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242
K AG+MI AWV+SF+LWAPAILFWQ+ VG RTV GEC+IQF S +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
Query: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
PV IMT+LYW I + ++ R K ++ P + S +Q + +K
Sbjct: 198 PVIIMTVLYWHISRASKSRIK--------------KDKKEPVANQDPVSPSLVQGRIVKP 243
Query: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362
+N PSS+ + + + D EN +E++ +++
Sbjct: 244 NNNN--------------MPSSDDGLEHNKIQNGKAPRDPVT--ENCVQGEEKESSNDST 287
Query: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422
++ ++ + D+ +E L D+ Q + G PK
Sbjct: 288 SVSAVASNM--------------RDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPK 333
Query: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482
S +S T T +V S G++ K+ +A++ T+ K+ S
Sbjct: 334 S--------DSCTPTNTTVEVVGSSGQNG-----DEKQNIVARKIVKMTKQPAKKKPPPS 380
Query: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPV 542
+EKK +T+ AILLAFIITW PYN+MVL+NTFC CIP T W +GYWLCYINST+NP
Sbjct: 381 --REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPA 438
Query: 543 CYALCNKTFRTTFKMLLLC 561
CYALCN TF+ TFK LL+C
Sbjct: 439 CYALCNATFKKTFKHLLMC 457
>gi|54792109 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 408 bits (1049), Expect = e-114
Identities = 223/499 (44%), Positives = 295/499 (59%), Gaps = 59/499 (11%)
Query: 63 HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122
+ ++VVFI + G L+LVTIIGNILV+VS KVN+ L+TVNNYFL SLACADLIIGV SM
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182
NL+T Y ++ W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY KRTT
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242
K AG+MI AWV+SF+LWAPAILFWQ+ VG RTV GEC+IQF S +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
Query: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
PV IMT+LYW I + ++ R K ++ P + S +Q + +K
Sbjct: 198 PVIIMTVLYWHISRASKSRIK--------------KDKKEPVANQDPVSPSLVQGRIVKP 243
Query: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362
+N PSS+ + + + D EN +E++ +++
Sbjct: 244 NNNN--------------MPSSDDGLEHNKIQNGKAPRDPVT--ENCVQGEEKESSNDST 287
Query: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422
++ ++ + D+ +E L D+ Q + G PK
Sbjct: 288 SVSAVASNM--------------RDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPK 333
Query: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482
S +S T T +V S G++ K+ +A++ T+ K+ S
Sbjct: 334 S--------DSCTPTNTTVEVVGSSGQNG-----DEKQNIVARKIVKMTKQPAKKKPPPS 380
Query: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPV 542
+EKK +T+ AILLAFIITW PYN+MVL+NTFC CIP T W +GYWLCYINST+NP
Sbjct: 381 --REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPA 438
Query: 543 CYALCNKTFRTTFKMLLLC 561
CYALCN TF+ TFK LL+C
Sbjct: 439 CYALCNATFKKTFKHLLMC 457
>gi|54792107 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 408 bits (1049), Expect = e-114
Identities = 223/499 (44%), Positives = 295/499 (59%), Gaps = 59/499 (11%)
Query: 63 HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122
+ ++VVFI + G L+LVTIIGNILV+VS KVN+ L+TVNNYFL SLACADLIIGV SM
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182
NL+T Y ++ W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY KRTT
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242
K AG+MI AWV+SF+LWAPAILFWQ+ VG RTV GEC+IQF S +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
Query: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
PV IMT+LYW I + ++ R K ++ P + S +Q + +K
Sbjct: 198 PVIIMTVLYWHISRASKSRIK--------------KDKKEPVANQDPVSPSLVQGRIVKP 243
Query: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362
+N PSS+ + + + D EN +E++ +++
Sbjct: 244 NNNN--------------MPSSDDGLEHNKIQNGKAPRDPVT--ENCVQGEEKESSNDST 287
Query: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422
++ ++ + D+ +E L D+ Q + G PK
Sbjct: 288 SVSAVASNM--------------RDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPK 333
Query: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482
S +S T T +V S G++ K+ +A++ T+ K+ S
Sbjct: 334 S--------DSCTPTNTTVEVVGSSGQNG-----DEKQNIVARKIVKMTKQPAKKKPPPS 380
Query: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPV 542
+EKK +T+ AILLAFIITW PYN+MVL+NTFC CIP T W +GYWLCYINST+NP
Sbjct: 381 --REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPA 438
Query: 543 CYALCNKTFRTTFKMLLLC 561
CYALCN TF+ TFK LL+C
Sbjct: 439 CYALCNATFKKTFKHLLMC 457
>gi|54792105 cholinergic receptor, muscarinic 2 [Homo sapiens]
Length = 466
Score = 408 bits (1049), Expect = e-114
Identities = 223/499 (44%), Positives = 295/499 (59%), Gaps = 59/499 (11%)
Query: 63 HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122
+ ++VVFI + G L+LVTIIGNILV+VS KVN+ L+TVNNYFL SLACADLIIGV SM
Sbjct: 18 YKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSM 77
Query: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182
NL+T Y ++ W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY KRTT
Sbjct: 78 NLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTT 137
Query: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242
K AG+MI AWV+SF+LWAPAILFWQ+ VG RTV GEC+IQF S +TFGTAIAAFY+
Sbjct: 138 KMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYL 197
Query: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
PV IMT+LYW I + ++ R K ++ P + S +Q + +K
Sbjct: 198 PVIIMTVLYWHISRASKSRIK--------------KDKKEPVANQDPVSPSLVQGRIVKP 243
Query: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362
+N PSS+ + + + D EN +E++ +++
Sbjct: 244 NNNN--------------MPSSDDGLEHNKIQNGKAPRDPVT--ENCVQGEEKESSNDST 287
Query: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422
++ ++ + D+ +E L D+ Q + G PK
Sbjct: 288 SVSAVASNM--------------RDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPK 333
Query: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482
S +S T T +V S G++ K+ +A++ T+ K+ S
Sbjct: 334 S--------DSCTPTNTTVEVVGSSGQNG-----DEKQNIVARKIVKMTKQPAKKKPPPS 380
Query: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPV 542
+EKK +T+ AILLAFIITW PYN+MVL+NTFC CIP T W +GYWLCYINST+NP
Sbjct: 381 --REKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPA 438
Query: 543 CYALCNKTFRTTFKMLLLC 561
CYALCN TF+ TFK LL+C
Sbjct: 439 CYALCNATFKKTFKHLLMC 457
>gi|52426748 cholinergic receptor, muscarinic 4 [Homo sapiens]
Length = 479
Score = 291 bits (745), Expect = 1e-78
Identities = 144/217 (66%), Positives = 173/217 (79%), Gaps = 13/217 (5%)
Query: 67 QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT 126
++VFIA +TG L+LVT++GNILV++S KVN+QL+TVNNYFL SLACADLIIG SMNL+T
Sbjct: 31 EMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYT 90
Query: 127 TYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAG 186
YII W LG + CDLWLA+DYV SNASVMNLL+ISFDRYF +T+PLTY A+RTTK AG
Sbjct: 91 VYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAG 150
Query: 187 VMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTI 246
+MI AWV+SFVLWAPAILFWQ+ VGKRTVP +CFIQFLS P +TFGTAIAAFY+PV I
Sbjct: 151 LMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVI 210
Query: 247 MTILY--------WRIYKE-----TEKRTKELAGLQA 270
MT+LY R++K EK+ K LA L++
Sbjct: 211 MTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKS 247
Score = 150 bits (380), Expect = 2e-36
Identities = 64/102 (62%), Positives = 85/102 (83%), Gaps = 1/102 (0%)
Query: 461 ATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC 520
A +A++FA R+Q+ K+++M+ +E+K +T+ AILLAFI+TWTPYN+MVLVNTFC SC
Sbjct: 371 ANVARKFASIARNQVRKKRQMA-ARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSC 429
Query: 521 IPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQ 562
IP T W++GYWLCY+NST+NP CYALCN TF+ TF+ LLLCQ
Sbjct: 430 IPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQ 471
>gi|149158709 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 182 bits (463), Expect = 6e-46
Identities = 137/500 (27%), Positives = 233/500 (46%), Gaps = 49/500 (9%)
Query: 67 QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT 126
Q++ + + + LVT+ N+LV+ + + ++L TV N +++SL+ ADLI+G + M +
Sbjct: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
Query: 127 TYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAG 186
Y++M++W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA
Sbjct: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
Query: 187 VMIGLAWVISFVLWAPAILFWQYFVGKRTV-PPGECFIQFLSEPTITFGTAIAAFYMPVT 245
I AW +SF LW IL W +F+ + +V +C F TAI FY+P
Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
Query: 246 IMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNR 305
+M Y +IYK + + + S S S +L+ ++ K +
Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINR---------------SLPSFSEIKLRPENPK-GDA 248
Query: 306 RKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIY 365
+K G+ W+ + S + + +++ +ED E +Y
Sbjct: 249 KKPGK------ESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQED-DREVDKLY 301
Query: 366 SIVLKLPGHSTILNSTK----LPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFP 421
L + + + + Q+ +E G+ A ++ + + D SF
Sbjct: 302 CFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGL--NTHGASEISEDQMLGDSQSF- 358
Query: 422 KSFSKLPIQLESAVDTAKTSDVNSSVGK--STATLPLSFKEATLAKRFALKTRSQITKRK 479
S D+ T++ GK S + L + + T KR +R ++
Sbjct: 359 -----------SRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTW-KRLRSHSRQYVS--- 403
Query: 480 RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTV 539
+ + +E+KAA+ L I+ AFI+ W PY I +V FC +C + WL YINST+
Sbjct: 404 GLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTL 463
Query: 540 NPVCYALCNKTFRTTFKMLL 559
NP+ Y LCN+ F+ TFK +L
Sbjct: 464 NPLIYPLCNENFKKTFKRIL 483
>gi|149158706 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 182 bits (463), Expect = 6e-46
Identities = 137/500 (27%), Positives = 233/500 (46%), Gaps = 49/500 (9%)
Query: 67 QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT 126
Q++ + + + LVT+ N+LV+ + + ++L TV N +++SL+ ADLI+G + M +
Sbjct: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
Query: 127 TYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAG 186
Y++M++W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA
Sbjct: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
Query: 187 VMIGLAWVISFVLWAPAILFWQYFVGKRTV-PPGECFIQFLSEPTITFGTAIAAFYMPVT 245
I AW +SF LW IL W +F+ + +V +C F TAI FY+P
Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
Query: 246 IMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNR 305
+M Y +IYK + + + S S S +L+ ++ K +
Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINR---------------SLPSFSEIKLRPENPK-GDA 248
Query: 306 RKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIY 365
+K G+ W+ + S + + +++ +ED E +Y
Sbjct: 249 KKPGK------ESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQED-DREVDKLY 301
Query: 366 SIVLKLPGHSTILNSTK----LPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFP 421
L + + + + Q+ +E G+ A ++ + + D SF
Sbjct: 302 CFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGL--NTHGASEISEDQMLGDSQSF- 358
Query: 422 KSFSKLPIQLESAVDTAKTSDVNSSVGK--STATLPLSFKEATLAKRFALKTRSQITKRK 479
S D+ T++ GK S + L + + T KR +R ++
Sbjct: 359 -----------SRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTW-KRLRSHSRQYVS--- 403
Query: 480 RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTV 539
+ + +E+KAA+ L I+ AFI+ W PY I +V FC +C + WL YINST+
Sbjct: 404 GLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTL 463
Query: 540 NPVCYALCNKTFRTTFKMLL 559
NP+ Y LCN+ F+ TFK +L
Sbjct: 464 NPLIYPLCNENFKKTFKRIL 483
>gi|149158704 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 182 bits (463), Expect = 6e-46
Identities = 137/500 (27%), Positives = 233/500 (46%), Gaps = 49/500 (9%)
Query: 67 QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT 126
Q++ + + + LVT+ N+LV+ + + ++L TV N +++SL+ ADLI+G + M +
Sbjct: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
Query: 127 TYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAG 186
Y++M++W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA
Sbjct: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
Query: 187 VMIGLAWVISFVLWAPAILFWQYFVGKRTV-PPGECFIQFLSEPTITFGTAIAAFYMPVT 245
I AW +SF LW IL W +F+ + +V +C F TAI FY+P
Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
Query: 246 IMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNR 305
+M Y +IYK + + + S S S +L+ ++ K +
Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINR---------------SLPSFSEIKLRPENPK-GDA 248
Query: 306 RKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIY 365
+K G+ W+ + S + + +++ +ED E +Y
Sbjct: 249 KKPGK------ESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQED-DREVDKLY 301
Query: 366 SIVLKLPGHSTILNSTK----LPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFP 421
L + + + + Q+ +E G+ A ++ + + D SF
Sbjct: 302 CFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGL--NTHGASEISEDQMLGDSQSF- 358
Query: 422 KSFSKLPIQLESAVDTAKTSDVNSSVGK--STATLPLSFKEATLAKRFALKTRSQITKRK 479
S D+ T++ GK S + L + + T KR +R ++
Sbjct: 359 -----------SRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTW-KRLRSHSRQYVS--- 403
Query: 480 RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTV 539
+ + +E+KAA+ L I+ AFI+ W PY I +V FC +C + WL YINST+
Sbjct: 404 GLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTL 463
Query: 540 NPVCYALCNKTFRTTFKMLL 559
NP+ Y LCN+ F+ TFK +L
Sbjct: 464 NPLIYPLCNENFKKTFKRIL 483
>gi|4504491 histamine receptor H1 [Homo sapiens]
Length = 487
Score = 182 bits (463), Expect = 6e-46
Identities = 137/500 (27%), Positives = 233/500 (46%), Gaps = 49/500 (9%)
Query: 67 QVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFT 126
Q++ + + + LVT+ N+LV+ + + ++L TV N +++SL+ ADLI+G + M +
Sbjct: 26 QLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNI 85
Query: 127 TYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAG 186
Y++M++W+LG C WL++DYVAS AS+ ++ ++ DRY S+ +PL Y RT RA
Sbjct: 86 LYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRAS 145
Query: 187 VMIGLAWVISFVLWAPAILFWQYFVGKRTV-PPGECFIQFLSEPTITFGTAIAAFYMPVT 245
I AW +SF LW IL W +F+ + +V +C F TAI FY+P
Sbjct: 146 ATILGAWFLSF-LWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTL 204
Query: 246 IMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNR 305
+M Y +IYK + + + S S S +L+ ++ K +
Sbjct: 205 LMLWFYAKIYKAVRQHCQHRELINR---------------SLPSFSEIKLRPENPK-GDA 248
Query: 306 RKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIY 365
+K G+ W+ + S + + +++ +ED E +Y
Sbjct: 249 KKPGK------ESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQED-DREVDKLY 301
Query: 366 SIVLKLPGHSTILNSTK----LPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFP 421
L + + + + Q+ +E G+ A ++ + + D SF
Sbjct: 302 CFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGL--NTHGASEISEDQMLGDSQSF- 358
Query: 422 KSFSKLPIQLESAVDTAKTSDVNSSVGK--STATLPLSFKEATLAKRFALKTRSQITKRK 479
S D+ T++ GK S + L + + T KR +R ++
Sbjct: 359 -----------SRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTW-KRLRSHSRQYVS--- 403
Query: 480 RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTV 539
+ + +E+KAA+ L I+ AFI+ W PY I +V FC +C + WL YINST+
Sbjct: 404 GLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTL 463
Query: 540 NPVCYALCNKTFRTTFKMLL 559
NP+ Y LCN+ F+ TFK +L
Sbjct: 464 NPLIYPLCNENFKKTFKRIL 483
>gi|194018562 histamine receptor H3 [Homo sapiens]
Length = 445
Score = 157 bits (396), Expect = 3e-38
Identities = 80/237 (33%), Positives = 133/237 (56%), Gaps = 4/237 (1%)
Query: 45 AAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNN 104
A+G + G W V +A L +L + T++GN LV+++F + L+T NN
Sbjct: 12 ASGALAGEAAAAGGARGFSAAWTAV-LAALMALLIVATVLGNALVMLAFVADSSLRTQNN 70
Query: 105 YFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISF 164
+FLL+LA +D ++G + L+ Y++ RW G C LWL +DY+ +S N+++IS+
Sbjct: 71 FFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISY 130
Query: 165 DRYFSITRPLTYRAKR-TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFI 223
DR+ S+TR ++YRA++ T+RA + L WV++F+L+ PAIL W+Y G ++P G C+
Sbjct: 131 DRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYA 190
Query: 224 QFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTK-ELAGL-QASGTEAETE 278
+F + F+ P +T IY ++RT+ L G +A+G E E
Sbjct: 191 EFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPE 247
Score = 75.5 bits (184), Expect = 1e-13
Identities = 38/107 (35%), Positives = 64/107 (59%), Gaps = 4/107 (3%)
Query: 457 SFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTF 516
S A+L KR + ++S T+R R+S +++K A++L+ I+ F + W PY +++++
Sbjct: 327 SASSASLEKRMKMVSQS-FTQRFRLS--RDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAA 383
Query: 517 CDS-CIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQ 562
C C+P ++ +WL + NS VNPV Y LC+ +FR F LL Q
Sbjct: 384 CHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQ 430
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 138 bits (348), Expect = 1e-32
Identities = 82/233 (35%), Positives = 119/233 (51%), Gaps = 8/233 (3%)
Query: 30 PPGTVTHFGSYNVSRAAG-NFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNIL 88
P G+ T N+S A N S+ D D + W+V+ + L ++ L T + N
Sbjct: 13 PAGSETWVPQANLSSAPSQNCSAKDYIYQDSIS--LPWKVLLVMLLA-LITLATTLSNAF 69
Query: 89 VIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAID 148
VI + ++L T NY + SLA DL++ ++ M + T Y + RW LG + CD WL+ D
Sbjct: 70 VIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSD 129
Query: 149 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQ 208
AS+++L VI+ DRY++IT + Y AKRT KRA VMI L WV S + P FW+
Sbjct: 130 ITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPP-FFWR 188
Query: 209 YFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKR 261
+ V EC + T + + AFY P ++ LY RIY E R
Sbjct: 189 QAKAEEEV--SECVVN-TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSR 238
Score = 71.2 bits (173), Expect = 2e-12
Identities = 39/144 (27%), Positives = 72/144 (50%), Gaps = 6/144 (4%)
Query: 422 KSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRM 481
K ++ + +S T+ + +NS V +P + ++ + ++K++
Sbjct: 249 KRLTRAQLITDSPGSTSSVTSINSRV----PDVPSESGSPVYVNQVKVRVSDALLEKKKL 304
Query: 482 SLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFC-DSC-IPKTFWNLGYWLCYINSTV 539
+E+KA +TL IL AFI+ W P+ I+ LV C D+C ++ WL Y+NS +
Sbjct: 305 MAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLI 364
Query: 540 NPVCYALCNKTFRTTFKMLLLCQC 563
NP+ Y + N+ F+ F L+ +C
Sbjct: 365 NPIIYTMSNEDFKQAFHKLIRFKC 388
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 138 bits (347), Expect = 2e-32
Identities = 80/234 (34%), Positives = 125/234 (53%), Gaps = 11/234 (4%)
Query: 64 TVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMN 123
T+ + + I ++ +T + N+ VI++ K+L NY + SLA DL++ V+ M
Sbjct: 18 TITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMP 77
Query: 124 LFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTK 183
L YI+M+RW LG C++WL++D S+++L VI+ DRY++IT + Y KRT K
Sbjct: 78 LSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAK 137
Query: 184 RAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMP 243
RA +MI W IS + P LFW+ + + PP +C IQ T + + AFY+P
Sbjct: 138 RAALMILTVWTISIFISMPP-LFWRSH-RRLSPPPSQCTIQH-DHVIYTIYSTLGAFYIP 194
Query: 244 VTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQ 297
+T++ ILY+RIY + Q G+ N T S S +S +L Q
Sbjct: 195 LTLILILYYRIYHAAKSL------YQKRGSSRHLSN--RSTDSQNSFASCKLTQ 240
Score = 62.0 bits (149), Expect = 1e-09
Identities = 30/86 (34%), Positives = 50/86 (58%)
Query: 477 KRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYIN 536
+R+++S +E+KAA+ L IL AFI++W P+ I L+ + + WL Y+N
Sbjct: 277 ERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVN 336
Query: 537 STVNPVCYALCNKTFRTTFKMLLLCQ 562
S +NP+ Y N+ F+ FK L+ C+
Sbjct: 337 SLINPLLYTSFNEDFKLAFKKLIRCR 362
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 135 bits (341), Expect = 8e-32
Identities = 83/277 (29%), Positives = 137/277 (49%), Gaps = 18/277 (6%)
Query: 24 PSDAGLPPGT-----VTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGI- 77
P+ G+P G V GS +R++ G D G V +V A G+
Sbjct: 41 PAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVG 100
Query: 78 -----LALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMN 132
L+ + GN+LVI+S N+ L+TV NYF+++LA ADL++ + T ++
Sbjct: 101 VFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG 160
Query: 133 RWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLA 192
WA G CD+W A+D + AS+++L IS DRY + L Y A T ++A ++ L
Sbjct: 161 FWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALL 220
Query: 193 WVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYW 252
WV++ V+ +L W K VPP E F E +++ +FY+P+ ++ ++Y
Sbjct: 221 WVVALVVSVGPLLGW-----KEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYC 275
Query: 253 RIYKETEKRTKEL-AGLQAS-GTEAETENFVHPTGSS 287
R+Y T+ L AG++ G +E +H G++
Sbjct: 276 RVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAA 312
Score = 64.7 bits (156), Expect = 2e-10
Identities = 32/100 (32%), Positives = 58/100 (58%), Gaps = 2/100 (2%)
Query: 472 RSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKT-FWNLGY 530
RS ++ R + +EKKAA+TL+ ++ F++ W P+ ++ + + P + + +
Sbjct: 330 RSSLSVRL-LKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIF 388
Query: 531 WLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRK 570
WL Y NS VNP+ Y ++ F+ F LL CQC +++RR+
Sbjct: 389 WLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRR 428
>gi|55956923 5-hydroxytryptamine (serotonin) receptor 1A [Homo
sapiens]
Length = 422
Score = 134 bits (338), Expect = 2e-31
Identities = 73/246 (29%), Positives = 129/246 (52%), Gaps = 5/246 (2%)
Query: 64 TVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMN 123
TV V + L G L ++GN V+ + + + L+ V NY + SLA DL++ V+ +
Sbjct: 32 TVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP 91
Query: 124 LFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTK 183
+ Y ++N+W LG + CDL++A+D + +S+++L I+ DRY++IT P+ Y KRT +
Sbjct: 92 MAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPR 151
Query: 184 RAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMP 243
RA +I L W+I F++ P +L W+ + P C I + T + AFY+P
Sbjct: 152 RAAALISLTWLIGFLISIPPMLGWR--TPEDRSDPDACTIS--KDHGYTIYSTFGAFYIP 207
Query: 244 VTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRS 303
+ +M +LY RI++ R ++ + T A+T + P + + E ++ +
Sbjct: 208 LLLMLVLYGRIFRAARFRIRKTV-KKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLG 266
Query: 304 NRRKYG 309
K G
Sbjct: 267 VESKAG 272
Score = 73.9 bits (180), Expect = 4e-13
Identities = 42/121 (34%), Positives = 62/121 (51%), Gaps = 5/121 (4%)
Query: 447 VGKSTATLPLSFKEATLA---KRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIIT 503
VG S LPL + F K +++M+L +E+K +TL I+ FI+
Sbjct: 298 VGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILC 357
Query: 504 WTPYNIMVLVNTFCDSC--IPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLC 561
W P+ I+ LV FC+S +P + WL Y NS +NPV YA NK F+ FK ++ C
Sbjct: 358 WLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKC 417
Query: 562 Q 562
+
Sbjct: 418 K 418
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 132 bits (333), Expect = 7e-31
Identities = 65/204 (31%), Positives = 115/204 (56%), Gaps = 4/204 (1%)
Query: 65 VWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNL 124
VW VV + + ++ L + GN+LVI + ++L+TV NYF+ SLACADL++G+ +
Sbjct: 31 VW-VVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPF 89
Query: 125 FTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKR 184
+I+M W GN C+ W +ID + AS+ L VI+ DRYF+IT P Y++ T +
Sbjct: 90 GAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNK 149
Query: 185 AGVMIGLAWVIS-FVLWAPAILFWQYFVGKRTVP--PGECFIQFLSEPTITFGTAIAAFY 241
A V+I + W++S + P + W + + E F + ++I +FY
Sbjct: 150 ARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFY 209
Query: 242 MPVTIMTILYWRIYKETEKRTKEL 265
+P+ IM +Y R+++E +++ +++
Sbjct: 210 VPLVIMVFVYSRVFQEAKRQLQKI 233
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 1/83 (1%)
Query: 477 KRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYIN 536
+R +KE KA +TL I+ F + W P+ I+ +V+ D+ I K + L W+ Y+N
Sbjct: 259 RRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVN 318
Query: 537 STVNPVCYALCNKTFRTTFKMLL 559
S NP+ Y + FR F+ LL
Sbjct: 319 SGFNPLIYCR-SPDFRIAFQELL 340
>gi|33598960 alpha-2B-adrenergic receptor [Homo sapiens]
Length = 450
Score = 131 bits (329), Expect = 2e-30
Identities = 114/499 (22%), Positives = 209/499 (41%), Gaps = 66/499 (13%)
Query: 63 HTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISM 122
++V IA L L TI GN LVI++ ++ L+ N FL+SLA AD+++ + +
Sbjct: 7 YSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLII 66
Query: 123 NLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT 182
++ W C+++LA+D + +S+++L IS DRY++++R L Y +KRT
Sbjct: 67 PFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTP 126
Query: 183 KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM 242
+R +I W+I+ V+ P ++ Y + P G + E ++I +F+
Sbjct: 127 RRIKCIILTVWLIAAVISLPPLI---YKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFA 183
Query: 243 PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKR 302
P IM ++Y RIY ++ + G +A G + E+ + +S +L +
Sbjct: 184 PCLIMILVYLRIYLIAKRSNRR--GPRAKGGPGQGESKQPRPDHGGALASAKLPALASVA 241
Query: 303 SNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETR 362
S R G H T + + + + + SW A+L NS +E + +
Sbjct: 242 SAREVNG--HSKSTGEKEEGETPEDTGTRALPPSW------AALPNSGQGQKEGVCGAS- 292
Query: 363 AIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPK 422
P + + EEE + E +A + P
Sbjct: 293 ---------------------PEDEAEEEEEEEEEEEECEPQAVPVS-----------PA 320
Query: 423 SFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMS 482
S P+Q T +G+ + + + R+Q+T+ KR +
Sbjct: 321 SACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQW----------WRRRAQLTREKRFT 370
Query: 483 LVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDS-C-IPKTFWNLGYWLCYINSTVN 540
V L+ ++ F++ W P+ + C C +P + +W+ Y NS++N
Sbjct: 371 FV--------LAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLN 422
Query: 541 PVCYALCNKTFRTTFKMLL 559
PV Y + N+ FR F+ +L
Sbjct: 423 PVIYTIFNQDFRRAFRRIL 441
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 128 bits (322), Expect = 1e-29
Identities = 71/245 (28%), Positives = 128/245 (52%), Gaps = 8/245 (3%)
Query: 25 SDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTII 84
S A LP G T + + P + +PL W + L ++ L+ +
Sbjct: 18 SAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQ--W-TAGMGLLMALIVLLIVA 74
Query: 85 GNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLW 144
GN+LVIV+ +L+T+ N F++SLA ADL++G++ + T ++ RW G+ C+LW
Sbjct: 75 GNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELW 134
Query: 145 LAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVIS-FVLWAPA 203
++D + AS+ L VI+ DRY +IT P Y++ T RA ++ W IS V + P
Sbjct: 135 TSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPI 194
Query: 204 ILFW---QYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEK 260
++ W + +R +C F++ +++ +FY+P+ IM +Y R+++E +K
Sbjct: 195 LMHWWRAESDEARRCYNDPKC-CDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQK 253
Query: 261 RTKEL 265
+ K++
Sbjct: 254 QVKKI 258
Score = 54.3 bits (129), Expect = 3e-07
Identities = 30/97 (30%), Positives = 47/97 (48%), Gaps = 1/97 (1%)
Query: 480 RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTV 539
R+ ++E+KA +TL I+ F + W P+ + +V F +P + WL Y NS
Sbjct: 313 RLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAF 372
Query: 540 NPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQR 576
NP+ Y + FR F+ LL C +RR + R
Sbjct: 373 NPIIYCR-SPDFRKAFQGLLCCARRAARRRHATHGDR 408
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 126 bits (317), Expect = 5e-29
Identities = 69/223 (30%), Positives = 113/223 (50%), Gaps = 6/223 (2%)
Query: 69 VFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTY 128
+ +A + ++ L T++ N V+ + + ++L T NY + SLA DL++ ++ M + Y
Sbjct: 39 ISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAY 98
Query: 129 IIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVM 188
I + W G + CD+WL+ D AS+++L VI+ DRY++IT L Y +RT A M
Sbjct: 99 TITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATM 158
Query: 189 IGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMT 248
I + W IS + P LFW+ K +C + S+ + T + AFY+P ++
Sbjct: 159 IAIVWAISICISIPP-LFWRQ--AKAQEEMSDCLVN-TSQISYTIYSTCGAFYIPSVLLI 214
Query: 249 ILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCS 291
ILY RIY+ R L G T + + + S CS
Sbjct: 215 ILYGRIYRAARNRILNPPSLY--GKRFTTAHLITGSAGSSLCS 255
Score = 70.1 bits (170), Expect = 5e-12
Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 10/127 (7%)
Query: 443 VNSSVGKSTATLPLSFKEA--------TLAKRFALKTRSQITKRKRMSLVKEKKAAQTLS 494
+ S G S +L S E +K +RKR+S +E+KA + L
Sbjct: 245 ITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILG 304
Query: 495 AILLAFIITWTPYNIMVLVNTFC-DSC-IPKTFWNLGYWLCYINSTVNPVCYALCNKTFR 552
IL AFII W P+ ++ LV C DSC I ++ WL Y+NS +NP+ Y + N+ FR
Sbjct: 305 IILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFR 364
Query: 553 TTFKMLL 559
F+ ++
Sbjct: 365 QAFQKIV 371
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 125 bits (314), Expect = 1e-28
Identities = 65/232 (28%), Positives = 124/232 (53%), Gaps = 7/232 (3%)
Query: 46 AGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNY 105
+GN S T P + + + + + + G L L ++GNILVI+S ++ L +V +Y
Sbjct: 5 SGNASDSSNCTQPPAPVN-ISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 106 FLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFD 165
++++LA ADL++ + + ++ WA G + C++W A+D + AS+M L +IS D
Sbjct: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123
Query: 166 RYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQF 225
RY ++ PL Y T +R + + W +S V+ + W ++ P E Q
Sbjct: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQI 178
Query: 226 LSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKEL-AGLQASGTEAE 276
EP +A+ +FY+P+ I+ ++Y R+Y ++ ++ L +GL+ +++E
Sbjct: 179 NEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSE 230
Score = 63.2 bits (152), Expect = 7e-10
Identities = 30/100 (30%), Positives = 60/100 (60%), Gaps = 2/100 (2%)
Query: 470 KTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIP-KTFWNL 528
KT++ + R + +EKKAA+TL ++ F++ W P+ +++ + +F P +T + +
Sbjct: 252 KTKTHFSVRL-LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKI 310
Query: 529 GYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKR 568
+WL Y+NS +NP+ Y ++ F+ F+ +L QC +K+
Sbjct: 311 VFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 125 bits (314), Expect = 1e-28
Identities = 65/232 (28%), Positives = 124/232 (53%), Gaps = 7/232 (3%)
Query: 46 AGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNY 105
+GN S T P + + + + + + G L L ++GNILVI+S ++ L +V +Y
Sbjct: 5 SGNASDSSNCTQPPAPVN-ISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 106 FLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFD 165
++++LA ADL++ + + ++ WA G + C++W A+D + AS+M L +IS D
Sbjct: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123
Query: 166 RYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQF 225
RY ++ PL Y T +R + + W +S V+ + W ++ P E Q
Sbjct: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQI 178
Query: 226 LSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKEL-AGLQASGTEAE 276
EP +A+ +FY+P+ I+ ++Y R+Y ++ ++ L +GL+ +++E
Sbjct: 179 NEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSE 230
Score = 63.2 bits (152), Expect = 7e-10
Identities = 30/100 (30%), Positives = 60/100 (60%), Gaps = 2/100 (2%)
Query: 470 KTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIP-KTFWNL 528
KT++ + R + +EKKAA+TL ++ F++ W P+ +++ + +F P +T + +
Sbjct: 252 KTKTHFSVRL-LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKI 310
Query: 529 GYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKR 568
+WL Y+NS +NP+ Y ++ F+ F+ +L QC +K+
Sbjct: 311 VFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 125 bits (314), Expect = 1e-28
Identities = 65/232 (28%), Positives = 124/232 (53%), Gaps = 7/232 (3%)
Query: 46 AGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNY 105
+GN S T P + + + + + + G L L ++GNILVI+S ++ L +V +Y
Sbjct: 5 SGNASDSSNCTQPPAPVN-ISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 106 FLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFD 165
++++LA ADL++ + + ++ WA G + C++W A+D + AS+M L +IS D
Sbjct: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123
Query: 166 RYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQF 225
RY ++ PL Y T +R + + W +S V+ + W ++ P E Q
Sbjct: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQI 178
Query: 226 LSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKEL-AGLQASGTEAE 276
EP +A+ +FY+P+ I+ ++Y R+Y ++ ++ L +GL+ +++E
Sbjct: 179 NEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSE 230
Score = 63.2 bits (152), Expect = 7e-10
Identities = 30/100 (30%), Positives = 60/100 (60%), Gaps = 2/100 (2%)
Query: 470 KTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIP-KTFWNL 528
KT++ + R + +EKKAA+TL ++ F++ W P+ +++ + +F P +T + +
Sbjct: 252 KTKTHFSVRL-LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKI 310
Query: 529 GYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKR 568
+WL Y+NS +NP+ Y ++ F+ F+ +L QC +K+
Sbjct: 311 VFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 125 bits (314), Expect = 1e-28
Identities = 65/232 (28%), Positives = 124/232 (53%), Gaps = 7/232 (3%)
Query: 46 AGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNY 105
+GN S T P + + + + + + G L L ++GNILVI+S ++ L +V +Y
Sbjct: 5 SGNASDSSNCTQPPAPVN-ISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHY 63
Query: 106 FLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFD 165
++++LA ADL++ + + ++ WA G + C++W A+D + AS+M L +IS D
Sbjct: 64 YIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISID 123
Query: 166 RYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQF 225
RY ++ PL Y T +R + + W +S V+ + W ++ P E Q
Sbjct: 124 RYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGW-----RQPAPEDETICQI 178
Query: 226 LSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKEL-AGLQASGTEAE 276
EP +A+ +FY+P+ I+ ++Y R+Y ++ ++ L +GL+ +++E
Sbjct: 179 NEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSE 230
Score = 63.2 bits (152), Expect = 7e-10
Identities = 30/100 (30%), Positives = 60/100 (60%), Gaps = 2/100 (2%)
Query: 470 KTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIP-KTFWNL 528
KT++ + R + +EKKAA+TL ++ F++ W P+ +++ + +F P +T + +
Sbjct: 252 KTKTHFSVRL-LKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKI 310
Query: 529 GYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKR 568
+WL Y+NS +NP+ Y ++ F+ F+ +L QC +K+
Sbjct: 311 VFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQ 350
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 125 bits (314), Expect = 1e-28
Identities = 71/207 (34%), Positives = 112/207 (54%), Gaps = 6/207 (2%)
Query: 50 SSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLS 109
SS T + L +++ L+G LAL+T N LVI + V ++L NY + S
Sbjct: 6 SSDQNLTSEELLNRMPSKILVSLTLSG-LALMTTTINSLVIAAIIVTRKLHHPANYLICS 64
Query: 110 LACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFS 169
LA D ++ V+ M YI+ W +G + CD+WL++D S+++L I+ DRY +
Sbjct: 65 LAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRA 124
Query: 170 ITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEP 229
IT + Y KRT K AG+MI + W+IS + P LFW++ + T EC I+
Sbjct: 125 ITDAVEYARKRTPKHAGIMITIVWIISVFISMPP-LFWRH---QGTSRDDECIIKH-DHI 179
Query: 230 TITFGTAIAAFYMPVTIMTILYWRIYK 256
T + AFY+P+ ++ ILY++IY+
Sbjct: 180 VSTIYSTFGAFYIPLALILILYYKIYR 206
Score = 76.6 bits (187), Expect = 6e-14
Identities = 36/88 (40%), Positives = 55/88 (62%), Gaps = 1/88 (1%)
Query: 477 KRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSC-IPKTFWNLGYWLCYI 535
+R+++S +E+KAA TL IL AF+I W P+ + LV CD C I + N WL Y+
Sbjct: 279 RRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYL 338
Query: 536 NSTVNPVCYALCNKTFRTTFKMLLLCQC 563
NS +NP+ Y + N+ F+ F+ L+ C+C
Sbjct: 339 NSLINPLIYTIFNEDFKKAFQKLVRCRC 366
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,445,964
Number of Sequences: 37866
Number of extensions: 922022
Number of successful extensions: 4916
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 533
Number of HSP's successfully gapped in prelim test: 221
Number of HSP's that attempted gapping in prelim test: 3223
Number of HSP's gapped (non-prelim): 1264
length of query: 590
length of database: 18,247,518
effective HSP length: 108
effective length of query: 482
effective length of database: 14,157,990
effective search space: 6824151180
effective search space used: 6824151180
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.