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Search of human proteins with 4502599
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502599 carbonyl reductase 1 [Homo sapiens]
(277 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502599 carbonyl reductase 1 [Homo sapiens] 554 e-158
gi|4502601 carbonyl reductase 3 [Homo sapiens] 406 e-113
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo... 62 7e-10
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo... 60 2e-09
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 59 4e-09
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom... 58 1e-08
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 56 3e-08
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 55 9e-08
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 54 2e-07
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 54 2e-07
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo... 49 4e-06
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom... 49 4e-06
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom... 49 4e-06
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo... 49 4e-06
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 49 6e-06
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 49 6e-06
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 48 8e-06
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 48 1e-05
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 47 1e-05
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 47 1e-05
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 47 1e-05
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 47 2e-05
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 47 2e-05
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 46 3e-05
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 46 4e-05
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 46 4e-05
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 46 4e-05
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 45 5e-05
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 45 5e-05
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 44 1e-04
>gi|4502599 carbonyl reductase 1 [Homo sapiens]
Length = 277
Score = 554 bits (1427), Expect = e-158
Identities = 277/277 (100%), Positives = 277/277 (100%)
Query: 1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH 60
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
Sbjct: 1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH 60
Query: 61 QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD 120
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
Sbjct: 61 QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD 120
Query: 121 VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK 180
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
Sbjct: 121 VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK 180
Query: 181 KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA 240
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
Sbjct: 181 KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA 240
Query: 241 TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW 277
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
Sbjct: 241 TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW 277
>gi|4502601 carbonyl reductase 3 [Homo sapiens]
Length = 277
Score = 406 bits (1043), Expect = e-113
Identities = 199/277 (71%), Positives = 235/277 (84%)
Query: 1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH 60
MSS VALVTG N+GIGLAI R+LCR FSGDVVLTARDV RGQAAVQQLQAEGLSPRFH
Sbjct: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60
Query: 61 QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD 120
QLDIDDLQSIRALRDFLRKEYGGL+VLVNNA +AFK DP PF I+AE+T+KTNFF TR+
Sbjct: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120
Query: 121 VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK 180
+C ELLP++KP GRVVN+SS+ +RA ++CS +LQ++F SET+TE +LV LM KFVEDTK
Sbjct: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180
Query: 181 KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA 240
VH++EGWP+S YGV+K+GVTVLSRI AR+L E+RK D+IL+NACCPG V+TDM G +
Sbjct: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240
Query: 241 TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW 277
++ EEGAETPVYLALLPPDA P GQ V +K V+ W
Sbjct: 241 IRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277
>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
sapiens]
Length = 336
Score = 61.6 bits (148), Expect = 7e-10
Identities = 80/305 (26%), Positives = 128/305 (41%), Gaps = 78/305 (25%)
Query: 9 LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAE-------GLSPRF-- 59
L+TG N G+G A +L RL V++ RD R + A QL+ E G P
Sbjct: 47 LITGANSGLGRATAAELLRL-GARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSG 105
Query: 60 ------HQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGI----AFKVADPTPFHIQAEV 109
+LD+ L+S+RA + +E LDVL+NNAGI K D E+
Sbjct: 106 VGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTED------GFEM 159
Query: 110 TMKTNFFGTRDVCTELLPLIKPQ--GRVVNVSSIMSVRALKSCSPELQQKFRSETITEEE 167
N G + LL L+K R+V VSS + ++ I ++
Sbjct: 160 QFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSS---------------KLYKYGDINFDD 204
Query: 168 LVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACC 227
L ++++ ++ S Y +K+ + +R AR+L +G + +N
Sbjct: 205 L---------NSEQSYNK-----SFCYSRSKLANILFTRELARRL----EGTNVTVNVLH 246
Query: 228 PGWVRT----------------DMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSE 271
PG VRT ++ K+P EGA+T +YLA P+ EG G++ +
Sbjct: 247 PGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLA-SSPEVEGVSGRYFGD 305
Query: 272 KRVEQ 276
+ E+
Sbjct: 306 CKEEE 310
>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
sapiens]
Length = 330
Score = 60.5 bits (145), Expect = 2e-09
Identities = 69/284 (24%), Positives = 123/284 (43%), Gaps = 47/284 (16%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 66
VA+VTGG GIG + + L RL V++ + ++ + V +++ E L+ + L D
Sbjct: 45 VAIVTGGTDGIGYSTAKHLARL-GMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFL-YCD 102
Query: 67 LQSIRALRDFLRK---EYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCT 123
L S+ ++R F++K + L VL+NNAG+ T + + N+ G +
Sbjct: 103 LASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGL--NYLGHFLLTN 160
Query: 124 ELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGV 183
LL +K G + + +++V + EL ++D +
Sbjct: 161 LLLDTLKESGSPGHSARVVTVSSATHYVAELN--------------------MDDLQSSA 200
Query: 184 HQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTD--------- 234
P +AY +K+ + VL H ++L +G + N PG V TD
Sbjct: 201 CYS---PHAAYAQSKLAL-VLFTYHLQRLL-AAEGSHVTANVVDPGVVNTDVYKHVFWAT 255
Query: 235 -----MAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKR 273
+ G K+P+EGA T +Y A + P+ EG G ++ ++
Sbjct: 256 RLAKKLLGWLLFKTPDEGAWTSIY-AAVTPELEGVGGHYLYNEK 298
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 59.3 bits (142), Expect = 4e-09
Identities = 69/271 (25%), Positives = 121/271 (44%), Gaps = 59/271 (21%)
Query: 9 LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQ 68
+VTG N GIG +L R G+++L RD+ + +AA + ++ E L+ + +D L
Sbjct: 42 IVTGANTGIGKQTALELARR-GGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD-LA 99
Query: 69 SIRALRDFLRK---EYGGLDVLVNNAGIAFKVADPTP--FHIQAEVTMKTNFFGTRDVCT 123
S++++R+F K E +D+L+NNAG+ T F +Q V +F T +
Sbjct: 100 SLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLD 159
Query: 124 ELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGV 183
+L R++N+SS+ V + I ++L K+ +TK
Sbjct: 160 KL--KASAPSRIINLSSLAHV---------------AGHIDFDDLNWQTRKY--NTK--- 197
Query: 184 HQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMA------- 236
+AY +K+ + + + ++LS + +G + +NA PG RT++
Sbjct: 198 --------AAYCQSKLAIVLFT----KELSRRLQGSGVTVNALHPGVARTELGRHTGIHG 245
Query: 237 --------GP---KATKSPEEGAETPVYLAL 256
GP KSPE A+ YLA+
Sbjct: 246 STFSSTTLGPIFWLLVKSPELAAQPSTYLAV 276
>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
sapiens]
Length = 377
Score = 57.8 bits (138), Expect = 1e-08
Identities = 77/289 (26%), Positives = 113/289 (39%), Gaps = 58/289 (20%)
Query: 8 ALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPR--FHQLDID 65
A+VTG N GIG +L R VVL R RG+AA L+ E + F LD+
Sbjct: 39 AVVTGANSGIGKMTALELARR-GARVVLACRSQERGEAAAFDLRQESGNNEVIFMALDLA 97
Query: 66 DLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTEL 125
L S+RA LD+L++NAGI+ F++ ++ N G + L
Sbjct: 98 SLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREAFNL----LLRVNHIGPFLLTHLL 153
Query: 126 LPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQ 185
LP LK+C+P S L D K+
Sbjct: 154 LP------------------CLKACAPSRVVVVASAAHCRGRL---------DFKRLDRP 186
Query: 186 KEGWPSS--AYGVTKIGVTVLSRIHARKLSEQRKGDKILLNAC-------------CPGW 230
GW AY TK+ + + AR+L+ Q + + A PGW
Sbjct: 187 VVGWRQELRAYADTKLA----NVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVPGW 242
Query: 231 VRTDMAGPKA---TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQ 276
+R + P A ++P GA+TP+Y A L E G++ + VE+
Sbjct: 243 LRP-LLRPLAWLVLRAPRGGAQTPLYCA-LQEGIEPLSGRYFANCHVEE 289
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 56.2 bits (134), Expect = 3e-08
Identities = 44/141 (31%), Positives = 68/141 (48%), Gaps = 11/141 (7%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRF--HQLDI 64
V ++TG N GIG R+L V + RDV +G++A +++ + + + +LD+
Sbjct: 41 VVVITGANTGIGKETARELASR-GARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDL 99
Query: 65 DDLQSIRALRDFLRKEYGGLDVLVNNAGIAF----KVADPTPFHIQAEVTMKTNFFGTRD 120
D +SIRA + E L +L+NNAG+ K AD H+ F
Sbjct: 100 SDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVN---HLGHFLLTY 156
Query: 121 VCTELLPLIKPQGRVVNVSSI 141
+ E L + P RVVNVSS+
Sbjct: 157 LLLERLKVSAP-ARVVNVSSV 176
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 54.7 bits (130), Expect = 9e-08
Identities = 47/143 (32%), Positives = 67/143 (46%), Gaps = 15/143 (10%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRF--HQLDI 64
V +VTG N GIG ++L + V L RDV +G+ +++Q + + +LD+
Sbjct: 43 VVVVTGANTGIGKETAKELAQR-GARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDL 101
Query: 65 DDLQSIRALRDFLRKEYGGLDVLVNNAGIAF----KVADPTPFHIQAEVTMKTNFFGTRD 120
D +SIRA E L VL+NNAG+ K AD HI N G
Sbjct: 102 SDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHI------GVNHLGHFL 155
Query: 121 VCTELLPLIKPQ--GRVVNVSSI 141
+ LL +K R+VNVSS+
Sbjct: 156 LTHLLLEKLKESAPSRIVNVSSL 178
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 53.5 bits (127), Expect = 2e-07
Identities = 46/153 (30%), Positives = 67/153 (43%), Gaps = 7/153 (4%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 66
V +VTGG +GIG IVR VV+ +D + G+A Q+L F D+
Sbjct: 11 VVVVTGGGRGIGAGIVRAFVN-SGARVVICDKDESGGRALEQELP----GAVFILCDVTQ 65
Query: 67 LQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQA-EVTMKTNFFGTRDVCTEL 125
++ L + +G LD +VNNAG P Q ++ N GT +
Sbjct: 66 EDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLA 125
Query: 126 LP-LIKPQGRVVNVSSIMSVRALKSCSPELQQK 157
LP L K QG V+N+SS++ P + K
Sbjct: 126 LPYLRKSQGNVINISSLVGAIGQAQAVPYVATK 158
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 53.5 bits (127), Expect = 2e-07
Identities = 60/260 (23%), Positives = 107/260 (41%), Gaps = 48/260 (18%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRF------H 60
+ALVTG + GIG A+ R L + VV AR V +++L AE S + +
Sbjct: 13 LALVTGASGGIGAAVARALVQQ-GLKVVGCARTVGN----IEELAAECKSAGYPGTLIPY 67
Query: 61 QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD 120
+ D+ + + I ++ +R ++ G+D+ +NNAG+A + + + + G +D
Sbjct: 68 RCDLSNEEDILSMFSAIRSQHSGVDICINNAGLA-----------RPDTLLSGSTSGWKD 116
Query: 121 VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK 180
+ ++V AL C+ E Q + + + ++ + ++
Sbjct: 117 MFN------------------VNVLALSICTREAYQSMKERNVDDGHIINI------NSM 152
Query: 181 KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA 240
G + Y TK VT L+ ++L E + I PG V T A
Sbjct: 153 SGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQ--THIRATCISPGVVETQFAFKLH 210
Query: 241 TKSPEEGAETPVYLALLPPD 260
K PE+ A T + L P+
Sbjct: 211 DKDPEKAAATYEQMKCLKPE 230
>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 49.3 bits (116), Expect = 4e-06
Identities = 43/137 (31%), Positives = 70/137 (51%), Gaps = 10/137 (7%)
Query: 10 VTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQS 69
+TG + G G R + G V+ A G A++ +E L R LD+ D ++
Sbjct: 34 ITGCDSGFGNLAARTFDK--KGFHVIAACLTESGSTALKAETSERL--RTVLLDVTDPEN 89
Query: 70 IRALRDFLRKEYG--GLDVLVNNAGIAFKVADPTPFHIQAEVT--MKTNFFGTRDVCTEL 125
++ +++ + G GL L+NNAG+ +A PT + + ++ N FG V +
Sbjct: 90 VKRTAQWVKNQVGEKGLWGLINNAGVPGVLA-PTDWLTLEDYREPIEVNLFGLISVTLNM 148
Query: 126 LPLIKP-QGRVVNVSSI 141
LPL+K QGRV+NVSS+
Sbjct: 149 LPLVKKAQGRVINVSSV 165
>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 49.3 bits (116), Expect = 4e-06
Identities = 43/137 (31%), Positives = 70/137 (51%), Gaps = 10/137 (7%)
Query: 10 VTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQS 69
+TG + G G R + G V+ A G A++ +E L R LD+ D ++
Sbjct: 34 ITGCDSGFGNLAARTFDK--KGFHVIAACLTESGSTALKAETSERL--RTVLLDVTDPEN 89
Query: 70 IRALRDFLRKEYG--GLDVLVNNAGIAFKVADPTPFHIQAEVT--MKTNFFGTRDVCTEL 125
++ +++ + G GL L+NNAG+ +A PT + + ++ N FG V +
Sbjct: 90 VKRTAQWVKNQVGEKGLWGLINNAGVPGVLA-PTDWLTLEDYREPIEVNLFGLISVTLNM 148
Query: 126 LPLIKP-QGRVVNVSSI 141
LPL+K QGRV+NVSS+
Sbjct: 149 LPLVKKAQGRVINVSSV 165
>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 49.3 bits (116), Expect = 4e-06
Identities = 43/137 (31%), Positives = 70/137 (51%), Gaps = 10/137 (7%)
Query: 10 VTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQS 69
+TG + G G R + G V+ A G A++ +E L R LD+ D ++
Sbjct: 34 ITGCDSGFGNLAARTFDK--KGFHVIAACLTESGSTALKAETSERL--RTVLLDVTDPEN 89
Query: 70 IRALRDFLRKEYG--GLDVLVNNAGIAFKVADPTPFHIQAEVT--MKTNFFGTRDVCTEL 125
++ +++ + G GL L+NNAG+ +A PT + + ++ N FG V +
Sbjct: 90 VKRTAQWVKNQVGEKGLWGLINNAGVPGVLA-PTDWLTLEDYREPIEVNLFGLISVTLNM 148
Query: 126 LPLIKP-QGRVVNVSSI 141
LPL+K QGRV+NVSS+
Sbjct: 149 LPLVKKAQGRVINVSSV 165
>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
sapiens]
Length = 319
Score = 49.3 bits (116), Expect = 4e-06
Identities = 43/137 (31%), Positives = 70/137 (51%), Gaps = 10/137 (7%)
Query: 10 VTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQS 69
+TG + G G R + G V+ A G A++ +E L R LD+ D ++
Sbjct: 34 ITGCDSGFGNLAARTFDK--KGFHVIAACLTESGSTALKAETSERL--RTVLLDVTDPEN 89
Query: 70 IRALRDFLRKEYG--GLDVLVNNAGIAFKVADPTPFHIQAEVT--MKTNFFGTRDVCTEL 125
++ +++ + G GL L+NNAG+ +A PT + + ++ N FG V +
Sbjct: 90 VKRTAQWVKNQVGEKGLWGLINNAGVPGVLA-PTDWLTLEDYREPIEVNLFGLISVTLNM 148
Query: 126 LPLIKP-QGRVVNVSSI 141
LPL+K QGRV+NVSS+
Sbjct: 149 LPLVKKAQGRVINVSSV 165
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 48.5 bits (114), Expect = 6e-06
Identities = 46/143 (32%), Positives = 73/143 (51%), Gaps = 16/143 (11%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH------ 60
VA+VTGG GIG AIV++L L S +VV+ +R + R ++A +LQA L P
Sbjct: 20 VAIVTGGATGIGKAIVKELLELGS-NVVIASRKLERLKSAADELQA-NLPPTKQARVIPI 77
Query: 61 QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAE---VTMKTNFFG 117
Q +I + + + L +G ++ LVNN G F P HI ++ ++TN G
Sbjct: 78 QCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQF--LSPAE-HISSKGWHAVLETNLTG 134
Query: 118 TRDVCTELLP--LIKPQGRVVNV 138
T +C + + + G +VN+
Sbjct: 135 TFYMCKAVYSSWMKEHGGSIVNI 157
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 48.5 bits (114), Expect = 6e-06
Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 8/137 (5%)
Query: 10 VTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQS 69
+TG + G G + R L G VL A +G ++ ++ L LD+ +S
Sbjct: 34 ITGCDSGFGKLLARQLDA--RGLRVLAACLTEKGAEQLRGQTSDRLETV--TLDVTKTES 89
Query: 70 IRALRDFLRK--EYGGLDVLVNNAGIAFKVADPTPFHIQAEVT-MKTNFFGTRDVCTELL 126
+ A ++++ GL LVNNAGI+ A Q VT + N G DV LL
Sbjct: 90 VAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLL 149
Query: 127 PLIK-PQGRVVNVSSIM 142
PL++ +GRVVNVSS+M
Sbjct: 150 PLVRRARGRVVNVSSVM 166
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 48.1 bits (113), Expect = 8e-06
Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 9 LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQ 68
LVTGG+ G+G A+ + L L G V G A + + SPR L +D +
Sbjct: 86 LVTGGDCGLGHALCKYLDEL--GFTVFAGVLNENGPGAEELRRT--CSPRLSVLQMDITK 141
Query: 69 SIRALRDFLRK-----EYGGLDVLVNNAGI-AFKVADPTPFHIQAEVTMKTNFFGTRDVC 122
++ ++D K + GL ++NNAG+ F + M NFFGT +V
Sbjct: 142 PVQ-IKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVT 200
Query: 123 TELLPLI-KPQGRVVNVSSI 141
LPL+ K +GR+VNVSS+
Sbjct: 201 KTFLPLLRKSKGRLVNVSSM 220
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 47.8 bits (112), Expect = 1e-05
Identities = 43/137 (31%), Positives = 68/137 (49%), Gaps = 8/137 (5%)
Query: 10 VTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQS 69
+TG + G G + R L G VL A +G ++ ++ L LD+ ++S
Sbjct: 34 ITGCDSGFGNLLARQLDA--RGLRVLAACLTEKGAEQLRGQTSDRLETV--TLDVTKMES 89
Query: 70 IRALRDFLRKEYG--GLDVLVNNAGIAFKVADPTPFHIQAEVTM-KTNFFGTRDVCTELL 126
I A ++++ G GL LVNNAGI + + + + M K N G V +L
Sbjct: 90 IAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSML 149
Query: 127 PLIK-PQGRVVNVSSIM 142
PL++ +GR+VNVSSI+
Sbjct: 150 PLVRRARGRIVNVSSIL 166
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 47.4 bits (111), Expect = 1e-05
Identities = 49/174 (28%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 4 GIHVALVTGGNKGIGLAIVRDLCR----LFSGDVVLTARDVTRGQAAVQQLQAEGLSPRF 59
G LVTG + G G ++ + L +F+G ++ +G V++L + S R
Sbjct: 54 GSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKD-----KGHDGVKELDSLN-SDRL 107
Query: 60 HQLDIDDLQS------IRALRDFLRKEYGGLDVLVNNAGIA-FKVADPTPFHIQAEVTMK 112
+ ++ S + +R L+ G+ LVNNAGI+ F + T +V +
Sbjct: 108 RTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVA-E 166
Query: 113 TNFFGTRDVCTELLPLIK-PQGRVVNVSSIMSVRALKSCSPELQQKFRSETITE 165
N +GT + LPLI+ +GRVVN+SS++ A + SP KF E ++
Sbjct: 167 VNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSD 220
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 47.4 bits (111), Expect = 1e-05
Identities = 49/174 (28%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 4 GIHVALVTGGNKGIGLAIVRDLCR----LFSGDVVLTARDVTRGQAAVQQLQAEGLSPRF 59
G LVTG + G G ++ + L +F+G ++ +G V++L + S R
Sbjct: 54 GSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKD-----KGHDGVKELDSLN-SDRL 107
Query: 60 HQLDIDDLQS------IRALRDFLRKEYGGLDVLVNNAGIA-FKVADPTPFHIQAEVTMK 112
+ ++ S + +R L+ G+ LVNNAGI+ F + T +V +
Sbjct: 108 RTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVA-E 166
Query: 113 TNFFGTRDVCTELLPLIK-PQGRVVNVSSIMSVRALKSCSPELQQKFRSETITE 165
N +GT + LPLI+ +GRVVN+SS++ A + SP KF E ++
Sbjct: 167 VNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSD 220
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 47.4 bits (111), Expect = 1e-05
Identities = 49/174 (28%), Positives = 82/174 (47%), Gaps = 19/174 (10%)
Query: 4 GIHVALVTGGNKGIGLAIVRDLCR----LFSGDVVLTARDVTRGQAAVQQLQAEGLSPRF 59
G LVTG + G G ++ + L +F+G ++ +G V++L + S R
Sbjct: 54 GSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKD-----KGHDGVKELDSLN-SDRL 107
Query: 60 HQLDIDDLQS------IRALRDFLRKEYGGLDVLVNNAGIA-FKVADPTPFHIQAEVTMK 112
+ ++ S + +R L+ G+ LVNNAGI+ F + T +V +
Sbjct: 108 RTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSLETYKQVA-E 166
Query: 113 TNFFGTRDVCTELLPLIK-PQGRVVNVSSIMSVRALKSCSPELQQKFRSETITE 165
N +GT + LPLI+ +GRVVN+SS++ A + SP KF E ++
Sbjct: 167 VNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSD 220
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 47.0 bits (110), Expect = 2e-05
Identities = 42/147 (28%), Positives = 67/147 (45%), Gaps = 17/147 (11%)
Query: 7 VALVTGGNKGIGLAIVRD---------LCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSP 57
V ++TG G+G + LC G + R++T A Q P
Sbjct: 54 VVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTH----KP 109
Query: 58 RFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFK-VADPTPFHIQAEVTMKTNFF 116
D+ D +I A + + +G +D+LVNNAGI+++ T + V M+TN+F
Sbjct: 110 YLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRV-METNYF 168
Query: 117 GTRDVCTELLP--LIKPQGRVVNVSSI 141
G + LLP + + QG +V +SSI
Sbjct: 169 GPVALTKALLPSMIKRRQGHIVAISSI 195
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 46.6 bits (109), Expect = 2e-05
Identities = 40/145 (27%), Positives = 73/145 (50%), Gaps = 9/145 (6%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH----QL 62
V VTG + GIG + L +L +VL+AR V + ++ G L
Sbjct: 52 VVWVTGASSGIGEELAYQLSKL-GVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPL 110
Query: 63 DIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFK-VADPTPFHIQAEVTMKTNFFGTRDV 121
D+ D S A + +E+G +D+LVNN G++ + + T + ++ ++ N+ GT +
Sbjct: 111 DLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKL-IELNYLGTVSL 169
Query: 122 CTELLP--LIKPQGRVVNVSSIMSV 144
+LP + + QG++V V+SI+ +
Sbjct: 170 TKCVLPHMIERKQGKIVTVNSILGI 194
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 46.2 bits (108), Expect = 3e-05
Identities = 34/169 (20%), Positives = 73/169 (43%), Gaps = 6/169 (3%)
Query: 9 LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQ 68
L+TGG +GIG + R+ + +VL R + ++++ G + D+ + +
Sbjct: 42 LITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNRE 101
Query: 69 SIRALRDFLRKEYGGLDVLVNNA----GIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTE 124
+ +R++ G + +LVNNA G + +D + F+ T+
Sbjct: 102 EVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPR 161
Query: 125 LLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMN 173
+L L G +V ++S++++ A+ K + E +GL++
Sbjct: 162 MLEL--QNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLD 208
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 45.8 bits (107), Expect = 4e-05
Identities = 47/151 (31%), Positives = 67/151 (44%), Gaps = 8/151 (5%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 66
VALVT GIG AI R L + VV+++R AV LQ EGLS +
Sbjct: 34 VALVTASTDGIGFAIARRLAQ-DGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGK 92
Query: 67 LQSIRALRDFLRKEYGGLDVLVNNAGI---AFKVADPTP--FHIQAEVTMKTNFFGTRDV 121
+ L K +GG+D+LV+NA + + D T + ++ +K T+ V
Sbjct: 93 AEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAV 152
Query: 122 CTELLPLIKPQGRVVNVSSIMSVRALKSCSP 152
E+ + G VV VSSI + SP
Sbjct: 153 VPEMEK--RGGGSVVIVSSIAAFSPSPGFSP 181
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 45.8 bits (107), Expect = 4e-05
Identities = 52/190 (27%), Positives = 85/190 (44%), Gaps = 12/190 (6%)
Query: 1 MSSGIHVALVTGGNKGIGLAIVRDLCR--LFSGDVVLTARDVTRGQAAVQQL-QAEGLSP 57
M++ L++G + GIGL + L VV T RD+ + + +A G +
Sbjct: 1 MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTL 60
Query: 58 RFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQA-EVTMKTNFF 116
QLD+ +S+ ++ G +DVLVNNAG+ V + A + TNFF
Sbjct: 61 TVAQLDVCSDESVAQCLSCIQ---GEVDVLVNNAGMGL-VGPLEGLSLAAMQNVFDTNFF 116
Query: 117 GTRDVCTELLPLIK--PQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLM-- 172
G + +LP +K QG +V +SS+M ++ + KF E E + L+
Sbjct: 117 GAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQF 176
Query: 173 NKFVEDTKKG 182
N F+ + G
Sbjct: 177 NIFISLVEPG 186
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 45.8 bits (107), Expect = 4e-05
Identities = 32/87 (36%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 66
VALVT GIG AI R L + VV+++R AV LQ EGLS +
Sbjct: 34 VALVTASTDGIGFAIARRLAQ-DRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGK 92
Query: 67 LQSIRALRDFLRKEYGGLDVLVNNAGI 93
+ L K +GG+D+LV+NA +
Sbjct: 93 AEDRERLVAMAVKLHGGIDILVSNAAV 119
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 45.4 bits (106), Expect = 5e-05
Identities = 43/137 (31%), Positives = 64/137 (46%), Gaps = 3/137 (2%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 66
VA+VTG GIG AI R L R VV+++R A+ +LQ EGLS +
Sbjct: 38 VAVVTGSTSGIGFAIARRLAR-DGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGK 96
Query: 67 LQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQA-EVTMKTNFFGTRDVCTEL 125
+ L + GG+D LV +AG+ V Q + + N + ++L
Sbjct: 97 AEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQL 156
Query: 126 LPLIK-PQGRVVNVSSI 141
LP ++ +G V+ VSSI
Sbjct: 157 LPYMENRRGAVILVSSI 173
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 45.4 bits (106), Expect = 5e-05
Identities = 43/137 (31%), Positives = 64/137 (46%), Gaps = 3/137 (2%)
Query: 7 VALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDD 66
VA+VTG GIG AI R L R VV+++R A+ +LQ EGLS +
Sbjct: 38 VAVVTGSTSGIGFAIARRLAR-DGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGK 96
Query: 67 LQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQA-EVTMKTNFFGTRDVCTEL 125
+ L + GG+D LV +AG+ V Q + + N + ++L
Sbjct: 97 AEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQL 156
Query: 126 LPLIK-PQGRVVNVSSI 141
LP ++ +G V+ VSSI
Sbjct: 157 LPYMENRRGAVILVSSI 173
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 44.3 bits (103), Expect = 1e-04
Identities = 41/138 (29%), Positives = 68/138 (49%), Gaps = 10/138 (7%)
Query: 10 VTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQS 69
+TG + G G + L + G VL + G +Q++ + L LDI D QS
Sbjct: 33 ITGCDSGFGRLLALQLDQ--RGFRVLASCLTPSGAEDLQRVASSRLHTTL--LDITDPQS 88
Query: 70 IRALRDFLRKEY--GGLDVLVNNAGIAFKVADPTPFHIQAEV--TMKTNFFGTRDVCTEL 125
++ ++ GL LVNNAG+A + PTP+ + + + N G V L
Sbjct: 89 VQQAAKWVEMHVKEAGLFGLVNNAGVA-GIIGPTPWLTRDDFQRVLNVNTMGPIGVTLAL 147
Query: 126 LPLI-KPQGRVVNVSSIM 142
LPL+ + +GRV+N++S++
Sbjct: 148 LPLLQQARGRVINITSVL 165
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,365,662
Number of Sequences: 37866
Number of extensions: 442370
Number of successful extensions: 1316
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 50
Number of HSP's that attempted gapping in prelim test: 1240
Number of HSP's gapped (non-prelim): 93
length of query: 277
length of database: 18,247,518
effective HSP length: 101
effective length of query: 176
effective length of database: 14,423,052
effective search space: 2538457152
effective search space used: 2538457152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.