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Search of human proteins with 4502553
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
(370 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 758 0.0
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 547 e-156
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 547 e-156
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 458 e-129
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 458 e-129
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 446 e-125
gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens] 306 2e-83
gi|27901803 protein serine kinase H1 [Homo sapiens] 280 1e-75
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 276 3e-74
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 260 2e-69
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 260 2e-69
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 256 2e-68
gi|14916455 protein serine kinase H2 [Homo sapiens] 251 1e-66
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 234 7e-62
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 233 3e-61
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 233 3e-61
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 233 3e-61
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 233 3e-61
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 233 3e-61
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 232 4e-61
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 232 4e-61
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 228 7e-60
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 228 7e-60
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 228 7e-60
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 228 7e-60
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 228 7e-60
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 228 7e-60
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 225 4e-59
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 225 4e-59
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 225 4e-59
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 758 bits (1957), Expect = 0.0
Identities = 370/370 (100%), Positives = 370/370 (100%)
Query: 1 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE 60
MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE
Sbjct: 1 MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE 60
Query: 61 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR 120
GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR
Sbjct: 61 GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR 120
Query: 121 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG 180
LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG
Sbjct: 121 LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG 180
Query: 181 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP 240
TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP
Sbjct: 181 TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP 240
Query: 241 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK 300
YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK
Sbjct: 241 YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK 300
Query: 301 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT 360
SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT
Sbjct: 301 SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT 360
Query: 361 ELSPTLPHQL 370
ELSPTLPHQL
Sbjct: 361 ELSPTLPHQL 370
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 547 bits (1410), Expect = e-156
Identities = 266/323 (82%), Positives = 294/323 (91%)
Query: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70
KQAEDI+ I++F++ LGTGAFSEV+LAE+K T KL A+KCI K+AL+GKE S+ENEIAVL
Sbjct: 14 KQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVL 73
Query: 71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVK 130
KIKH NIVAL+DIYES HLYL+MQLVSGGELFDRIVEKGFYTE+DAS LI QVLDAV
Sbjct: 74 RKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVY 133
Query: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
YLH +GIVHRDLKPENLLYYS DE+SKIMISDFGLSKME G V+STACGTPGYVAPEVL
Sbjct: 134 YLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL 193
Query: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250
AQKPYSKAVDCWSIGVIAYILLCGYPPFYDEND+KLFEQILKAEYEFDSPYWDDISDSAK
Sbjct: 194 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAK 253
Query: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNAT 310
DFIR+LMEKDP KR+TCEQA +HPWIAGDTAL+KNIH+SVS QI+KNFAKSKW+QAFNAT
Sbjct: 254 DFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNAT 313
Query: 311 AVVRHMRKLQLGTSQEGQGQTAS 333
AVVRHMRKL LG+S + + S
Sbjct: 314 AVVRHMRKLHLGSSLDSSNASVS 336
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 547 bits (1410), Expect = e-156
Identities = 266/323 (82%), Positives = 294/323 (91%)
Query: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70
KQAEDI+ I++F++ LGTGAFSEV+LAE+K T KL A+KCI K+AL+GKE S+ENEIAVL
Sbjct: 14 KQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVL 73
Query: 71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVK 130
KIKH NIVAL+DIYES HLYL+MQLVSGGELFDRIVEKGFYTE+DAS LI QVLDAV
Sbjct: 74 RKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVY 133
Query: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
YLH +GIVHRDLKPENLLYYS DE+SKIMISDFGLSKME G V+STACGTPGYVAPEVL
Sbjct: 134 YLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL 193
Query: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250
AQKPYSKAVDCWSIGVIAYILLCGYPPFYDEND+KLFEQILKAEYEFDSPYWDDISDSAK
Sbjct: 194 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAK 253
Query: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNAT 310
DFIR+LMEKDP KR+TCEQA +HPWIAGDTAL+KNIH+SVS QI+KNFAKSKW+QAFNAT
Sbjct: 254 DFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNAT 313
Query: 311 AVVRHMRKLQLGTSQEGQGQTAS 333
AVVRHMRKL LG+S + + S
Sbjct: 314 AVVRHMRKLHLGSSLDSSNASVS 336
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 458 bits (1179), Expect = e-129
Identities = 219/319 (68%), Positives = 272/319 (85%), Gaps = 3/319 (0%)
Query: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70
K EDI +Y+ R+ LG+GAFSEV+LA+++ + LVA+KCI K+AL GKE +ENEIAVL
Sbjct: 23 KHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVL 82
Query: 71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVK 130
+I HPNIVAL+D++ES HLYL M+LV+GGELFDRI+E+G YTE+DAS L+ QVL AV
Sbjct: 83 RRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVS 142
Query: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
YLH LGIVHRDLKPENLLY + EDSKIM+SDFGLSK++ G++L TACGTPGYVAPE+L
Sbjct: 143 YLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQ-AGNMLGTACGTPGYVAPELL 201
Query: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250
QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SAK
Sbjct: 202 EQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAK 261
Query: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNAT 310
DFIRHL+E+DP+KRFTC+QAL+H WI+GDTA D++I SVSEQI+KNFA++ WK+AFNAT
Sbjct: 262 DFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNAT 321
Query: 311 AVVRHMRKLQLGTSQEGQG 329
+ +RH+RK LG EG+G
Sbjct: 322 SFLRHIRK--LGQIPEGEG 338
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 458 bits (1179), Expect = e-129
Identities = 219/319 (68%), Positives = 272/319 (85%), Gaps = 3/319 (0%)
Query: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70
K EDI +Y+ R+ LG+GAFSEV+LA+++ + LVA+KCI K+AL GKE +ENEIAVL
Sbjct: 89 KHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVL 148
Query: 71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVK 130
+I HPNIVAL+D++ES HLYL M+LV+GGELFDRI+E+G YTE+DAS L+ QVL AV
Sbjct: 149 RRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVS 208
Query: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
YLH LGIVHRDLKPENLLY + EDSKIM+SDFGLSK++ G++L TACGTPGYVAPE+L
Sbjct: 209 YLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQ-AGNMLGTACGTPGYVAPELL 267
Query: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250
QKPY KAVD W++GVI+YILLCGYPPFYDE+D +LF QIL+A YEFDSP+WDDIS+SAK
Sbjct: 268 EQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAK 327
Query: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNAT 310
DFIRHL+E+DP+KRFTC+QAL+H WI+GDTA D++I SVSEQI+KNFA++ WK+AFNAT
Sbjct: 328 DFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNAT 387
Query: 311 AVVRHMRKLQLGTSQEGQG 329
+ +RH+RK LG EG+G
Sbjct: 388 SFLRHIRK--LGQIPEGEG 404
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 446 bits (1148), Expect = e-125
Identities = 220/317 (69%), Positives = 264/317 (83%), Gaps = 2/317 (0%)
Query: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVL 70
KQ +IR + F +VLG+GAFSEV L + + T KL A+KCI K++ ++ S+ENEIAVL
Sbjct: 14 KQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-KKSPAFRDSSLENEIAVL 72
Query: 71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVK 130
KIKH NIV L+DIYES H YL+MQLVSGGELFDRI+E+G YTE+DAS +I QVL AVK
Sbjct: 73 KKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVK 132
Query: 131 YLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL 190
YLH+ GIVHRDLKPENLLY + +E+SKIMI+DFGLSKME G ++STACGTPGYVAPEVL
Sbjct: 133 YLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNG-IMSTACGTPGYVAPEVL 191
Query: 191 AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAK 250
AQKPYSKAVDCWSIGVI YILLCGYPPFY+E ++KLFE+I + YEF+SP+WDDIS+SAK
Sbjct: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 251
Query: 251 DFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNAT 310
DFI HL+EKDP +R+TCE+AL HPWI G+TAL ++I+ SVS QI+KNFAKSKW+QAFNA
Sbjct: 252 DFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFAKSKWRQAFNAA 311
Query: 311 AVVRHMRKLQLGTSQEG 327
AVV HMRKL + G
Sbjct: 312 AVVHHMRKLHMNLHSPG 328
>gi|83776596 CaM kinase-like vesicle-associated [Homo sapiens]
Length = 501
Score = 306 bits (784), Expect = 2e-83
Identities = 156/357 (43%), Positives = 225/357 (63%), Gaps = 12/357 (3%)
Query: 10 WKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAV 69
+ Q ++ D YD V+ T F E+ A+DK T KL K K + +NEI +
Sbjct: 14 YNQPSEVTDRYDLGQVIKTEEFCEIFRAKDKTTGKLHTCKKFQKRDGRKVRKAAKNEIGI 73
Query: 70 LHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAV 129
L +KHPNI+ L D++ + ++ ++L +G E+FD I+++G+Y+ERD S ++ QVL+AV
Sbjct: 74 LKMVKHPNILQLVDVFVTRKEYFIFLELATGREVFDWILDQGYYSERDTSNVVRQVLEAV 133
Query: 130 KYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEV 189
YLH L IVHR+LK ENL+YY+ ++SKI+ISDF L+K+E+ ++ CGTP Y+APEV
Sbjct: 134 AYLHSLKIVHRNLKLENLVYYNRLKNSKIVISDFHLAKLEN--GLIKEPCGTPEYLAPEV 191
Query: 190 LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDE--------NDAKLFEQILKAEYEFDSPY 241
+ ++ Y + VDCW+IGVI YILL G PPFY+E +D LF +IL +YEFDSPY
Sbjct: 192 VGRQRYGRPVDCWAIGVIMYILLSGNPPFYEEVEEDDYENHDKNLFRKILAGDYEFDSPY 251
Query: 242 WDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKS 301
WDDIS +AKD + LME + ++R T E+A+ H WI+G+ A DKNI V QI+KNFA++
Sbjct: 252 WDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWISGNAASDKNIKDGVCAQIEKNFARA 311
Query: 302 KWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEP 358
KWK+A T +++ +R + S Q+AS + TP A G A P
Sbjct: 312 KWKKAVRVTTLMKRLRAPE--QSSTAAAQSASATDTATPGAAGGATAAAASGATSAP 366
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 280 bits (717), Expect = 1e-75
Identities = 136/281 (48%), Positives = 194/281 (69%), Gaps = 5/281 (1%)
Query: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79
YD + ++G G+FS V+ E + T++ AIK I + EG+E E+E+ VL +++H NI+
Sbjct: 98 YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGRE-VCESELRVLRRVRHANII 156
Query: 80 ALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVH 139
L +++E+ +Y++M+L +GGELFDRI+ KG +TERDA+R++ VLD V+YLH LGI H
Sbjct: 157 QLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITH 216
Query: 140 RDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS--VLSTACGTPGYVAPEVLAQKPYSK 197
RDLKPENLLYY DSKI+I+DFGL+ G ++ T CGTP Y+APEVL +KPY+
Sbjct: 217 RDLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTN 276
Query: 198 AVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLM 257
+VD W++GVIAYILL G PF D+N +L+ QIL+ +Y + W +S+ AKDFI L+
Sbjct: 277 SVDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLL 336
Query: 258 EKDPEKRFTCEQALQHPWIAGDTALD--KNIHQSVSEQIKK 296
DP R T QAL+HPW+ A KN+H+S+S+ + K
Sbjct: 337 TVDPGARMTALQALRHPWVVSMAASSSMKNLHRSISQNLLK 377
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 276 bits (705), Expect = 3e-74
Identities = 147/323 (45%), Positives = 208/323 (64%), Gaps = 16/323 (4%)
Query: 16 IRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKH 75
+ D ++ LG GA S V + K TQK A+K + K+ ++ K + EI VL ++ H
Sbjct: 42 LSDFFEVESELGRGATSIVYRCKQKGTQKPYALK-VLKKTVDKK--IVRTEIGVLLRLSH 98
Query: 76 PNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDL 135
PNI+ L +I+E+ + L+++LV+GGELFDRIVEKG+Y+ERDA+ + Q+L+AV YLH+
Sbjct: 99 PNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158
Query: 136 GIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
GIVHRDLKPENLLY + D+ + I+DFGLSK+ + ++ T CGTPGY APE+L Y
Sbjct: 159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAY 218
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDE-NDAKLFEQILKAEYEFDSPYWDDISDSAKDFIR 254
VD WS+G+I YILLCG+ PFYDE D +F +IL EY F SP+WD++S +AKD +R
Sbjct: 219 GPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVR 278
Query: 255 HLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVR 314
L+ DP+KR T QALQHPW+ G A +H ++ K Q FNA ++
Sbjct: 279 KLIVLDPKKRLTTFQALQHPWVTGKAA--NFVHMDTAQ---------KKLQEFNARRKLK 327
Query: 315 HMRKLQLGTSQEGQGQTASHGEL 337
K + +S+ G ++SHG +
Sbjct: 328 AAVKAVVASSRLGSA-SSSHGSI 349
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 260 bits (664), Expect = 2e-69
Identities = 135/329 (41%), Positives = 204/329 (62%), Gaps = 10/329 (3%)
Query: 5 VEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME 64
V G R ++ + + Y V+G G F+ V D+ T K A+K I K GKE +E
Sbjct: 378 VNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIE 437
Query: 65 NEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQ 124
NE+++L ++KHPNI+ L + E+ L+L+M+LV GG+LFD I YTERD S +++
Sbjct: 438 NEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYN 497
Query: 125 VLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSK-IMISDFGLSKMEDPGSVLSTACGTPG 183
+ +A++YLH L IVHRD+KPENLL + +K + + DFGL+ + + L T CGTP
Sbjct: 498 LANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE--GPLYTVCGTPT 555
Query: 184 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAK--LFEQILKAEYEFDSPY 241
YVAPE++A+ Y VD W+ GVI YILLCG+PPF EN+ + LF+QIL + EF +PY
Sbjct: 556 YVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPY 615
Query: 242 WDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKS 301
WD+I+DSAK+ I +++ + E R T Q L HPW++ D + + N+ V+ ++K++F +
Sbjct: 616 WDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNA 675
Query: 302 KWKQAFNATAVVRHMRKLQLGTSQEGQGQ 330
KQ T V + + T+ + +GQ
Sbjct: 676 LPKQNSTTTGV-----SVIMNTALDKEGQ 699
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 260 bits (664), Expect = 2e-69
Identities = 135/329 (41%), Positives = 204/329 (62%), Gaps = 10/329 (3%)
Query: 5 VEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME 64
V G R ++ + + Y V+G G F+ V D+ T K A+K I K GKE +E
Sbjct: 379 VNGNRCSESSTLLEKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIE 438
Query: 65 NEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQ 124
NE+++L ++KHPNI+ L + E+ L+L+M+LV GG+LFD I YTERD S +++
Sbjct: 439 NEVSILRRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYN 498
Query: 125 VLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSK-IMISDFGLSKMEDPGSVLSTACGTPG 183
+ +A++YLH L IVHRD+KPENLL + +K + + DFGL+ + + L T CGTP
Sbjct: 499 LANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE--GPLYTVCGTPT 556
Query: 184 YVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAK--LFEQILKAEYEFDSPY 241
YVAPE++A+ Y VD W+ GVI YILLCG+PPF EN+ + LF+QIL + EF +PY
Sbjct: 557 YVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPY 616
Query: 242 WDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKS 301
WD+I+DSAK+ I +++ + E R T Q L HPW++ D + + N+ V+ ++K++F +
Sbjct: 617 WDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQENNMQAEVTGKLKQHFNNA 676
Query: 302 KWKQAFNATAVVRHMRKLQLGTSQEGQGQ 330
KQ T V + + T+ + +GQ
Sbjct: 677 LPKQNSTTTGV-----SVIMNTALDKEGQ 700
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 256 bits (655), Expect = 2e-68
Identities = 133/287 (46%), Positives = 186/287 (64%), Gaps = 7/287 (2%)
Query: 16 IRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKH 75
I + Y +G G F+ V ++ T + A+K I K GKE ++NE+++L ++KH
Sbjct: 386 ITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKH 445
Query: 76 PNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDL 135
PNIV L + + LYL+M+LV GG+LFD I YTERDAS +++ + A+KYLH L
Sbjct: 446 PNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSL 505
Query: 136 GIVHRDLKPENLLYYSLDEDSK-IMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKP 194
IVHRD+KPENLL Y + SK + + DFGL+ + D L T CGTP YVAPE++A+
Sbjct: 506 NIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVD--GPLYTVCGTPTYVAPEIIAETG 563
Query: 195 YSKAVDCWSIGVIAYILLCGYPPFYDENDAK--LFEQILKAEYEFDSPYWDDISDSAKDF 252
Y VD W+ GVI YILLCG+PPF D + LF+QIL + +F SPYWD++SDSAK+
Sbjct: 564 YGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKEL 623
Query: 253 IRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQ-SVSEQIKKNF 298
I ++ D ++RF+ Q L+HPW+ D L +N HQ SV+ +IKK+F
Sbjct: 624 ITMMLLVDVDQRFSAVQVLEHPWV-NDDGLPENEHQLSVAGKIKKHF 669
>gi|14916455 protein serine kinase H2 [Homo sapiens]
Length = 385
Score = 251 bits (640), Expect = 1e-66
Identities = 127/281 (45%), Positives = 185/281 (65%), Gaps = 9/281 (3%)
Query: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIV 79
YD + ++GTG+FS V+ E K T+K AIK + EG+E + +E++VL ++ H IV
Sbjct: 63 YDIKALIGTGSFSRVVRVEQKTTKKPFAIKVMETREREGREACV-SELSVLRRVSHRYIV 121
Query: 80 ALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVH 139
L +I+E+ +Y++M+L +GGELFDR++ +G +TERDA R++ V D ++YLH L I H
Sbjct: 122 QLMEIFETEDQVYMVMELATGGELFDRLIAQGSFTERDAVRILQMVADGIRYLHALQITH 181
Query: 140 RDLKPENLLYYSLDEDSKIMISDFGL--SKMEDPGSVLSTACGTPGYVAPEVLAQKPYSK 197
R+LKPENLLYY E+SKI+I+DFGL S + + T CGTP Y+APEVL +KPY+
Sbjct: 182 RNLKPENLLYYHPGEESKILITDFGLAYSGKKSGDWTMKTLCGTPEYIAPEVLLRKPYTS 241
Query: 198 AVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLM 257
AVD W++GVI Y LL G+ PF DE+ +L+ +ILK +Y + W IS AKDFI L+
Sbjct: 242 AVDMWALGVITYALLSGFLPFDDESQTRLYRKILKGKYNYTGEPWPSISHLAKDFIDKLL 301
Query: 258 EKDPEKRFTCEQALQHPWI----AGDTALDKNIHQSVSEQI 294
+ R + QAL HPW+ AG + KN+ +++S +
Sbjct: 302 ILEAGHRMSAGQALDHPWVITMAAGSSM--KNLQRAISRNL 340
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 234 bits (598), Expect = 7e-62
Identities = 121/273 (44%), Positives = 175/273 (64%), Gaps = 7/273 (2%)
Query: 13 AEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHK 72
A ++ Y+ V+G G F+ V + T++ A+K I K L+GKE +++EI ++
Sbjct: 349 AANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQS 408
Query: 73 IKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYL 132
+ HPNIV L ++YE+ +YLI++ V GG+LFD I+E + E DA+ +I + A+ ++
Sbjct: 409 LSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHM 468
Query: 133 HDLGIVHRDLKPENLLYY-SLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLA 191
HD IVHRDLKPENLL + D+ + + ++DFGL+K + T CGTP YVAPE+L+
Sbjct: 469 HDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAK--HVVRPIFTVCGTPTYVAPEILS 526
Query: 192 QKPYSKAVDCWSIGVIAYILLCGYPPFY--DENDAKLFEQILKAEYEFDSPYWDDISDSA 249
+K Y VD W+ GVI YILLCG+PPF + + +LF I +EF PYWD+ISD+A
Sbjct: 527 EKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNISDAA 586
Query: 250 KDFIRHLMEKDPEKRFTCEQALQHPWI--AGDT 280
KD + L+ DP+KR+T Q LQHPWI AG T
Sbjct: 587 KDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKT 619
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 233 bits (593), Expect = 3e-61
Identities = 125/299 (41%), Positives = 179/299 (59%), Gaps = 3/299 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V K + + A K I + L ++ +E E + +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I
Sbjct: 192 GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNATAVV 313
++ +P KR T +QAL+HPW+ + + +H Q E ++K A+ K K A T +V
Sbjct: 252 MLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLV 310
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 233 bits (593), Expect = 3e-61
Identities = 125/299 (41%), Positives = 179/299 (59%), Gaps = 3/299 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V K + + A K I + L ++ +E E + +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I
Sbjct: 192 GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNATAVV 313
++ +P KR T +QAL+HPW+ + + +H Q E ++K A+ K K A T +V
Sbjct: 252 MLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLV 310
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 233 bits (593), Expect = 3e-61
Identities = 125/299 (41%), Positives = 179/299 (59%), Gaps = 3/299 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V K + + A K I + L ++ +E E + +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I
Sbjct: 192 GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNATAVV 313
++ +P KR T +QAL+HPW+ + + +H Q E ++K A+ K K A T +V
Sbjct: 252 MLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLV 310
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 233 bits (593), Expect = 3e-61
Identities = 125/299 (41%), Positives = 179/299 (59%), Gaps = 3/299 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V K + + A K I + L ++ +E E + +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I
Sbjct: 192 GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNATAVV 313
++ +P KR T +QAL+HPW+ + + +H Q E ++K A+ K K A T +V
Sbjct: 252 MLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLV 310
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 233 bits (593), Expect = 3e-61
Identities = 125/299 (41%), Positives = 179/299 (59%), Gaps = 3/299 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V K + + A K I + L ++ +E E + +KHP
Sbjct: 12 DDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V ++H
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHD 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I
Sbjct: 192 GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNATAVV 313
++ +P KR T +QAL+HPW+ + + +H Q E ++K A+ K K A T +V
Sbjct: 252 MLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLV 310
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 232 bits (592), Expect = 4e-61
Identities = 126/294 (42%), Positives = 176/294 (59%), Gaps = 3/294 (1%)
Query: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHPNI 78
Y + LG GAFS V + A K I + L ++ +E E + +KHPNI
Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72
Query: 79 VALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIV 138
V L D GH YLI LV+GGELF+ IV + +Y+E DAS I Q+L+AV + H +G+V
Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132
Query: 139 HRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPYSK 197
HRDLKPENLL S + + + ++DFGL+ ++E GTPGY++PEVL + PY K
Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK 192
Query: 198 AVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLM 257
VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I ++
Sbjct: 193 PVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML 252
Query: 258 EKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNAT 310
+P KR T +AL+HPWI+ + + +H Q + +KK A+ K K A T
Sbjct: 253 TINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTT 306
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 232 bits (592), Expect = 4e-61
Identities = 126/294 (42%), Positives = 176/294 (59%), Gaps = 3/294 (1%)
Query: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHPNI 78
Y + LG GAFS V + A K I + L ++ +E E + +KHPNI
Sbjct: 13 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 72
Query: 79 VALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIV 138
V L D GH YLI LV+GGELF+ IV + +Y+E DAS I Q+L+AV + H +G+V
Sbjct: 73 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVV 132
Query: 139 HRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPYSK 197
HRDLKPENLL S + + + ++DFGL+ ++E GTPGY++PEVL + PY K
Sbjct: 133 HRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGK 192
Query: 198 AVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLM 257
VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I ++
Sbjct: 193 PVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKML 252
Query: 258 EKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNAT 310
+P KR T +AL+HPWI+ + + +H Q + +KK A+ K K A T
Sbjct: 253 TINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTT 306
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 228 bits (581), Expect = 7e-60
Identities = 125/296 (42%), Positives = 175/296 (59%), Gaps = 3/296 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V T + A K I + L ++ +E E + +KHP
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V + H G
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I
Sbjct: 192 GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNAT 310
++ +P KR T +AL+HPWI + + +H Q + +KK A+ K K A T
Sbjct: 252 MLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTT 307
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 228 bits (581), Expect = 7e-60
Identities = 125/296 (42%), Positives = 175/296 (59%), Gaps = 3/296 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V T + A K I + L ++ +E E + +KHP
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V + H G
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I
Sbjct: 192 GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNAT 310
++ +P KR T +AL+HPWI + + +H Q + +KK A+ K K A T
Sbjct: 252 MLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTT 307
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 228 bits (581), Expect = 7e-60
Identities = 125/296 (42%), Positives = 175/296 (59%), Gaps = 3/296 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V T + A K I + L ++ +E E + +KHP
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V + H G
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I
Sbjct: 192 GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNAT 310
++ +P KR T +AL+HPWI + + +H Q + +KK A+ K K A T
Sbjct: 252 MLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTT 307
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 228 bits (581), Expect = 7e-60
Identities = 125/296 (42%), Positives = 175/296 (59%), Gaps = 3/296 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V T + A K I + L ++ +E E + +KHP
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V + H G
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I
Sbjct: 192 GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNAT 310
++ +P KR T +AL+HPWI + + +H Q + +KK A+ K K A T
Sbjct: 252 MLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTT 307
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 228 bits (581), Expect = 7e-60
Identities = 125/296 (42%), Positives = 175/296 (59%), Gaps = 3/296 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V T + A K I + L ++ +E E + +KHP
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V + H G
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I
Sbjct: 192 GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNAT 310
++ +P KR T +AL+HPWI + + +H Q + +KK A+ K K A T
Sbjct: 252 MLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTT 307
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 228 bits (581), Expect = 7e-60
Identities = 125/296 (42%), Positives = 175/296 (59%), Gaps = 3/296 (1%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + LG GAFS V T + A K I + L ++ +E E + +KHP
Sbjct: 12 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L++V + H G
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNG 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
IVHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL + PY
Sbjct: 132 IVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ +L++QI Y+F SP WD ++ AKD I
Sbjct: 192 GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINK 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNAT 310
++ +P KR T +AL+HPWI + + +H Q + +KK A+ K K A T
Sbjct: 252 MLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTT 307
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 225 bits (574), Expect = 4e-59
Identities = 126/321 (39%), Positives = 182/321 (56%), Gaps = 3/321 (0%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + +G GAFS V T A K I + L ++ +E E + +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L+AV + H +G
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
+VHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL ++ Y
Sbjct: 132 VVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I
Sbjct: 192 GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNATAVVR 314
++ +P KR T +AL+HPW+ + + +H Q E +KK A+ K K A T +
Sbjct: 252 MLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLAT 311
Query: 315 HMRKLQLGTSQEGQGQTASHG 335
+ T+ TA+ G
Sbjct: 312 RNFSVGRQTTAPATMSTAASG 332
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 225 bits (574), Expect = 4e-59
Identities = 126/321 (39%), Positives = 182/321 (56%), Gaps = 3/321 (0%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + +G GAFS V T A K I + L ++ +E E + +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L+AV + H +G
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
+VHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL ++ Y
Sbjct: 132 VVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I
Sbjct: 192 GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNATAVVR 314
++ +P KR T +AL+HPW+ + + +H Q E +KK A+ K K A T +
Sbjct: 252 MLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLAT 311
Query: 315 HMRKLQLGTSQEGQGQTASHG 335
+ T+ TA+ G
Sbjct: 312 RNFSVGRQTTAPATMSTAASG 332
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 225 bits (574), Expect = 4e-59
Identities = 126/321 (39%), Positives = 182/321 (56%), Gaps = 3/321 (0%)
Query: 18 DIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGS-MENEIAVLHKIKHP 76
D Y + +G GAFS V T A K I + L ++ +E E + +KH
Sbjct: 12 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 71
Query: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLG 136
NIV L D G YL+ LV+GGELF+ IV + +Y+E DAS I Q+L+AV + H +G
Sbjct: 72 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMG 131
Query: 137 IVHRDLKPENLLYYSLDEDSKIMISDFGLS-KMEDPGSVLSTACGTPGYVAPEVLAQKPY 195
+VHRDLKPENLL S + + + ++DFGL+ +++ GTPGY++PEVL ++ Y
Sbjct: 132 VVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY 191
Query: 196 SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255
K VD W+ GVI YILL GYPPF+DE+ KL++QI Y+F SP WD ++ AK+ I
Sbjct: 192 GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQ 251
Query: 256 LMEKDPEKRFTCEQALQHPWIAGDTALDKNIH-QSVSEQIKKNFAKSKWKQAFNATAVVR 314
++ +P KR T +AL+HPW+ + + +H Q E +KK A+ K K A T +
Sbjct: 252 MLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLAT 311
Query: 315 HMRKLQLGTSQEGQGQTASHG 335
+ T+ TA+ G
Sbjct: 312 RNFSVGRQTTAPATMSTAASG 332
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,810,690
Number of Sequences: 37866
Number of extensions: 651236
Number of successful extensions: 4459
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 603
Number of HSP's successfully gapped in prelim test: 207
Number of HSP's that attempted gapping in prelim test: 1900
Number of HSP's gapped (non-prelim): 997
length of query: 370
length of database: 18,247,518
effective HSP length: 104
effective length of query: 266
effective length of database: 14,309,454
effective search space: 3806314764
effective search space used: 3806314764
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.