BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] (825 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 1674 0.0 gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens] 554 e-157 gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens] 552 e-157 gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens] 548 e-156 gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens] 547 e-155 gi|208609985 SH2 domain containing 3A [Homo sapiens] 363 e-100 gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens] 347 3e-95 gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens] 347 3e-95 gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 74 7e-13 gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 62 3e-09 gi|169790811 SHC (Src homology 2 domain containing) transforming... 62 3e-09 gi|224586793 src homology 2 domain-containing transforming prote... 61 4e-09 gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 61 5e-09 gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 61 5e-09 gi|194239668 SHC (Src homology 2 domain containing) transforming... 60 1e-08 gi|194239664 SHC (Src homology 2 domain containing) transforming... 60 1e-08 gi|194239662 SHC (Src homology 2 domain containing) transforming... 60 1e-08 gi|32261324 SHC (Src homology 2 domain containing) transforming ... 60 1e-08 gi|222446609 rai-like protein [Homo sapiens] 59 2e-08 gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 55 2e-07 gi|5729856 GRB2-related adaptor protein [Homo sapiens] 54 5e-07 gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 52 2e-06 gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 52 2e-06 gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 52 2e-06 gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 52 2e-06 gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 52 2e-06 gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 52 2e-06 gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 52 3e-06 gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 52 3e-06 gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 49 1e-05 >gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] Length = 825 Score = 1674 bits (4334), Expect = 0.0 Identities = 825/825 (100%), Positives = 825/825 (100%) Query: 1 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP 60 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP Sbjct: 1 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP 60 Query: 61 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF 120 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF Sbjct: 61 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF 120 Query: 121 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL 180 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL Sbjct: 121 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL 180 Query: 181 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP 240 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP Sbjct: 181 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP 240 Query: 241 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE 300 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE Sbjct: 241 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE 300 Query: 301 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC 360 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC Sbjct: 301 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC 360 Query: 361 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS 420 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS Sbjct: 361 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS 420 Query: 421 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD 480 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD Sbjct: 421 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD 480 Query: 481 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA 540 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA Sbjct: 481 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA 540 Query: 541 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE 600 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE Sbjct: 541 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE 600 Query: 601 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT 660 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT Sbjct: 601 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT 660 Query: 661 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ 720 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ Sbjct: 661 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ 720 Query: 721 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT 780 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT Sbjct: 721 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT 780 Query: 781 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL Sbjct: 781 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825 >gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens] Length = 860 Score = 554 bits (1428), Expect = e-157 Identities = 331/752 (44%), Positives = 456/752 (60%), Gaps = 59/752 (7%) Query: 86 TQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLS 145 T D +E P +D H E R + +YVKFSKE++I+D +PEKL KELEEEL LS Sbjct: 156 TGDVEEERPPRDVHSE----RAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLS 211 Query: 146 SEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205 S DLRSHAWYHGRIPR+VSE LVQR+GDFL+RDSL+S G++VLTC+W+N A HFKIN+ V Sbjct: 212 STDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVV 271 Query: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEH 265 ++ E+Y+ +QY FE ESFD +P LVR +VG+R+ +S+QSGAII+ P+NRT PLR LE Sbjct: 272 VKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEAS 331 Query: 266 YGTSPGQAREGS-LTKGRPDVA--KRLSLTM-GGVQA----REQNLPRGNLL-RNKEKSG 316 YG G ++ S ++ P + KR S+TM G+ A R P L R ++ Sbjct: 332 YGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIR 391 Query: 317 SQPACLDHMQDRRALSLKAHQSES---YLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPA 373 S +D + D + +S S Y + ++ + + P SPV R SEP Sbjct: 392 SCALSMDQIPDLHSPMSPISESPSSPAYSTV-TRVHAAPAAPSATALPASPVARRSSEPQ 450 Query: 374 LSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELN 433 L P + ++ G S S K P P L S P + +YC+L Sbjct: 451 LCPGSAPKTHGESDKGP--HTSPSHTLGKASPSPS----LSSYSDPDS-----GHYCQLQ 499 Query: 434 PAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQ 493 P RG++ + + S + R+ G ER E + Sbjct: 500 PPV-----RGSREWAATETSSQQA-----------RSYG-----------ERLKELSENG 532 Query: 494 MEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIA 553 +G W K F P++E SSF P F+S +P +N+PLE +L++ KEL D + +A Sbjct: 533 APEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLA 591 Query: 554 QHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDI 613 +HV +DC VARILGV++EM+ MGV G+EL+TLPHG QLRLD++ER +TM+I +AVDI Sbjct: 592 RHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDI 651 Query: 614 LGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQY 673 LGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M QI+RLE+TW LR ++ Sbjct: 652 LGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRH 711 Query: 674 TQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKN 733 T+ AILYEK+LKPF K L+EG+E P +N + P ++PL+TL+E + EG + W Sbjct: 712 TEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLLECDSAPPEGPEPWGST 769 Query: 734 DQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGA 793 + E++L HL AR +A Y NAE L GFQ E+ E+ TEFQMRLLWGS+GA Sbjct: 770 EHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGA 829 Query: 794 QVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825 +Q RYEKF+++LTALS KLE P V+ +EL Sbjct: 830 SSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 860 >gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens] Length = 703 Score = 552 bits (1423), Expect = e-157 Identities = 323/722 (44%), Positives = 445/722 (61%), Gaps = 55/722 (7%) Query: 116 EYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFL 175 +YVKFSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL Sbjct: 25 DYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFL 84 Query: 176 VRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYV 235 +RDSL+S G++VLTC+W+N A HFKIN+ V++ E+Y+ +QY FE ESFD +P LVR +V Sbjct: 85 IRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHV 144 Query: 236 GNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLT 292 G+R+ +S+QSGAII+ P+NRT PLR LE YG G ++ S ++ P + KR S+T Sbjct: 145 GSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVT 204 Query: 293 M-GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLP 343 M G+ A R P L R ++ S +D + D + +S S Y Sbjct: 205 MTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYST 264 Query: 344 IGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKP 403 + ++ + + P SPV R SEP L P + ++ G S S K Sbjct: 265 V-TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKA 321 Query: 404 PPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQN 463 P P L S P + +YC+L P RG++ + + S + Sbjct: 322 SPSPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA------ 361 Query: 464 EAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESK 523 R+ G ER E + +G W K F P++E SSF P F+S Sbjct: 362 -----RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSL 404 Query: 524 FLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGL 583 +P +N+PLE +L++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+ Sbjct: 405 LIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGM 464 Query: 584 ELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGD 643 EL+TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+ Sbjct: 465 ELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGN 524 Query: 644 LYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPN 703 ++SF+A+M AL+M QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P + Sbjct: 525 MFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLS 582 Query: 704 NVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAER 763 N + P ++PL+TL+E + EG + W + E++L HL AR +A Y NAE Sbjct: 583 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV 642 Query: 764 ILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQA 823 L GFQ E+ E+ TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ + Sbjct: 643 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSS 701 Query: 824 EL 825 EL Sbjct: 702 EL 703 >gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens] Length = 700 Score = 548 bits (1413), Expect = e-156 Identities = 321/721 (44%), Positives = 444/721 (61%), Gaps = 55/721 (7%) Query: 117 YVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLV 176 +V+FSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL+ Sbjct: 23 FVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI 82 Query: 177 RDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236 RDSL+S G++VLTC+W+N A HFKIN+ V++ E+Y+ +QY FE ESFD +P LVR +VG Sbjct: 83 RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG 142 Query: 237 NRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLTM 293 +R+ +S+QSGAII+ P+NRT PLR LE YG G ++ S ++ P + KR S+TM Sbjct: 143 SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM 202 Query: 294 -GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLPI 344 G+ A R P L R ++ S +D + D + +S S Y + Sbjct: 203 TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV 262 Query: 345 GCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPP 404 ++ + + P SPV R SEP L P + ++ G S S K Sbjct: 263 -TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKAS 319 Query: 405 PKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNE 464 P P L S P + +YC+L P RG++ + + S + Sbjct: 320 PSPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA------- 358 Query: 465 APGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKF 524 R+ G ER E + +G W K F P++E SSF P F+S Sbjct: 359 ----RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLL 402 Query: 525 LPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLE 584 +P +N+PLE +L++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+E Sbjct: 403 IPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGME 462 Query: 585 LITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDL 644 L+TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG++ Sbjct: 463 LLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNM 522 Query: 645 YSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNN 704 +SF+A+M AL+M QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P +N Sbjct: 523 FSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSN 580 Query: 705 VSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERI 764 + P ++PL+TL+E + EG + W + E++L HL AR +A Y NAE Sbjct: 581 TTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVK 640 Query: 765 LAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAE 824 L GFQ E+ E+ TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ +E Sbjct: 641 LQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSE 699 Query: 825 L 825 L Sbjct: 700 L 700 >gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens] Length = 702 Score = 547 bits (1410), Expect = e-155 Identities = 321/720 (44%), Positives = 443/720 (61%), Gaps = 55/720 (7%) Query: 118 VKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVR 177 V+FSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL+R Sbjct: 26 VQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIR 85 Query: 178 DSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGN 237 DSL+S G++VLTC+W+N A HFKIN+ V++ E+Y+ +QY FE ESFD +P LVR +VG+ Sbjct: 86 DSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGS 145 Query: 238 RRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLTM- 293 R+ +S+QSGAII+ P+NRT PLR LE YG G ++ S ++ P + KR S+TM Sbjct: 146 RKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMT 205 Query: 294 GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLPIG 345 G+ A R P L R ++ S +D + D + +S S Y + Sbjct: 206 DGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV- 264 Query: 346 CKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPP 405 ++ + + P SPV R SEP L P + ++ G S S K P Sbjct: 265 TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKASP 322 Query: 406 KPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEA 465 P L S P + +YC+L P RG++ + + S + Sbjct: 323 SPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA-------- 360 Query: 466 PGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFL 525 R+ G ER E + +G W K F P++E SSF P F+S + Sbjct: 361 ---RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLI 405 Query: 526 PPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLEL 585 P +N+PLE +L++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+EL Sbjct: 406 PRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMEL 465 Query: 586 ITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLY 645 +TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+++ Sbjct: 466 LTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMF 525 Query: 646 SFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNV 705 SF+A+M AL+M QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P +N Sbjct: 526 SFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSNT 583 Query: 706 SVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERIL 765 + P ++PL+TL+E + EG + W + E++L HL AR +A Y NAE L Sbjct: 584 TFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKL 643 Query: 766 AGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825 GFQ E+ E+ TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ +EL Sbjct: 644 QGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 702 >gi|208609985 SH2 domain containing 3A [Homo sapiens] Length = 576 Score = 363 bits (933), Expect = e-100 Identities = 244/674 (36%), Positives = 348/674 (51%), Gaps = 110/674 (16%) Query: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206 EDL WYHG + RQ +E L+Q++GDFLVR S S GN V++C+W+ A HF++ R L Sbjct: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67 Query: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHY 266 R +Q E E F SIP LV Y+ RRP+SQ +GA++ +P+ PLR Sbjct: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLR------ 121 Query: 267 GTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQ 326 E +L G + LR ++ S SQPA L HM Sbjct: 122 ----RSFSEDTLMDGPARIEP---------------------LRARKWSNSQPADLAHMG 156 Query: 327 DRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPAL--SPAVVRRVSS 384 R +G++ S P S + RT S+P L +PA + V+ Sbjct: 157 RSRE--------------------DPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVA- 195 Query: 385 DARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGA 444 ++LR SD QL K P KP + P ++P + YCEL P Sbjct: 196 -----DSLRASDGQLQAKAPTKPPRTPSFELPDASER----PPTYCELVP---------- 236 Query: 445 KLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEF 504 ++PS QG T+ P P E PW A E+ + F Sbjct: 237 RVPS-VQG------TSPSQSCPEP---------------EAPWWEAEEDEEE---ENRCF 271 Query: 505 VTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVA 564 P E SF P++ S L P+N+PLE +L + LF + P A H+L +DC+ Sbjct: 272 TRPQAEI--SFCPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQAT 329 Query: 565 RILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRA 624 +LGV+ + R NMGVSSGLEL+TLPHGH LRL+++ERH T+A+ A+ +LGC+G LE+RA Sbjct: 330 GLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERA 389 Query: 625 ATLSKIIQVAVELK-DSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQ 683 A L ++++A+ L+ + GDL +A+M AL MPQ++RLE TW LR +T+ A+ +E++ Sbjct: 390 AALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQE 449 Query: 684 LKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNH 743 LKP + L EG C P V++P + P+V L+ EG ++ D+SCE +L Sbjct: 450 LKPLMRALDEG-AGPC-DPGEVALPHVAPMVRLL-------EGEEVAGPLDESCERLLRT 500 Query: 744 LATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEK 803 L AR M A +R A + L GF+P+ E+ E T F RLLWGS+GA + ER+EK Sbjct: 501 LHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEK 560 Query: 804 FNQILTALSRKLEP 817 F ++L LS++LEP Sbjct: 561 FQRVLGVLSQRLEP 574 >gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens] Length = 506 Score = 347 bits (889), Expect = 3e-95 Identities = 202/468 (43%), Positives = 282/468 (60%), Gaps = 18/468 (3%) Query: 358 SPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPS 417 S P+SP + T + +PA + A + A R S+ QLCP PK + Sbjct: 57 SESPSSPAYSTVTRVHAAPAAPSATALPA-SPVARRSSEPQLCPGSAPKTHGESDKGPHT 115 Query: 418 SPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLI 477 SPS L + L+ G +L +GS A + + R+ G Sbjct: 116 SPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSRE--WAATETSSQQARSYG----- 168 Query: 478 LDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAML 537 ER E + +G W K F P++E SSF P F+S +P +N+PLE +L Sbjct: 169 ------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLL 221 Query: 538 KRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLD 597 ++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+EL+TLPHG QLRLD Sbjct: 222 RKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLD 281 Query: 598 IIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMP 657 ++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M Sbjct: 282 LLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMA 341 Query: 658 QITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLM 717 QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P +N + P ++PL+TL+ Sbjct: 342 QISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLL 399 Query: 718 ERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEI 777 E + EG + W + E++L HL AR +A Y NAE L GFQ E+ E+ Sbjct: 400 ECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEV 459 Query: 778 CKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825 TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ +EL Sbjct: 460 FSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 506 >gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens] Length = 506 Score = 347 bits (889), Expect = 3e-95 Identities = 202/468 (43%), Positives = 282/468 (60%), Gaps = 18/468 (3%) Query: 358 SPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPS 417 S P+SP + T + +PA + A + A R S+ QLCP PK + Sbjct: 57 SESPSSPAYSTVTRVHAAPAAPSATALPA-SPVARRSSEPQLCPGSAPKTHGESDKGPHT 115 Query: 418 SPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLI 477 SPS L + L+ G +L +GS A + + R+ G Sbjct: 116 SPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSRE--WAATETSSQQARSYG----- 168 Query: 478 LDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAML 537 ER E + +G W K F P++E SSF P F+S +P +N+PLE +L Sbjct: 169 ------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLL 221 Query: 538 KRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLD 597 ++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+EL+TLPHG QLRLD Sbjct: 222 RKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLD 281 Query: 598 IIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMP 657 ++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M Sbjct: 282 LLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMA 341 Query: 658 QITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLM 717 QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P +N + P ++PL+TL+ Sbjct: 342 QISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLL 399 Query: 718 ERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEI 777 E + EG + W + E++L HL AR +A Y NAE L GFQ E+ E+ Sbjct: 400 ECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEV 459 Query: 778 CKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825 TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ +EL Sbjct: 460 FSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 506 >gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] Length = 822 Score = 73.6 bits (179), Expect = 7e-13 Identities = 44/140 (31%), Positives = 71/140 (50%), Gaps = 14/140 (10%) Query: 119 KFSKERHIMD---RTPEKL--KKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGD 173 KF RH + R+P+ L + + +S + L WYHG IPR ++ L+++ GD Sbjct: 420 KFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGD 479 Query: 174 FLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRC 233 FLVR+S PG +VL+ +HF I Y Y+FE F +IP L+ Sbjct: 480 FLVRESHGKPGEYVLSVYSDGQRRHFIIQ---------YVDNMYRFEGTGFSNIPQLIDH 530 Query: 234 YVGNRRPISQQSGAIIFQPI 253 + ++ I+++SG ++ PI Sbjct: 531 HYTTKQVITKKSGVVLLNPI 550 >gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo sapiens] Length = 475 Score = 61.6 bits (148), Expect = 3e-09 Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 13/99 (13%) Query: 145 SSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI--N 202 + E LR WYHGR+ R+ +E +++ DGDFLVRDS+++PG +VLT +H + Sbjct: 371 TEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDP 430 Query: 203 RTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI 241 V+R + F+SI L+ ++ N +PI Sbjct: 431 EGVVRTKDVL-----------FESISHLIDHHLQNGQPI 458 >gi|169790811 SHC (Src homology 2 domain containing) transforming protein 2 [Homo sapiens] Length = 582 Score = 61.6 bits (148), Expect = 3e-09 Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 13/99 (13%) Query: 145 SSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI--N 202 + E LR WYHGR+ R+ +E +++ DGDFLVRDS+++PG +VLT +H + Sbjct: 478 TEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDP 537 Query: 203 RTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI 241 V+R + F+SI L+ ++ N +PI Sbjct: 538 EGVVRTKDVL-----------FESISHLIDHHLQNGQPI 565 >gi|224586793 src homology 2 domain-containing transforming protein C3 [Homo sapiens] Length = 594 Score = 61.2 bits (147), Expect = 4e-09 Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 10/110 (9%) Query: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206 E+L++ WY G + R+ +E L+++DGDFLVR S ++PG+FVLT A+H L Sbjct: 492 EELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKH-------L 544 Query: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI-SQQSGAIIFQPINR 255 L + ++ + + FDSI L+ ++ + PI S S + QP+ R Sbjct: 545 LLVDPEGTIRTKDRV--FDSISHLINHHLESSLPIVSAGSELCLQQPVER 592 >gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] Length = 764 Score = 60.8 bits (146), Expect = 5e-09 Identities = 49/161 (30%), Positives = 76/161 (47%), Gaps = 23/161 (14%) Query: 149 LRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRL 208 L WYHG IPR L+ GDFLVR+S +VL+ W L +HF I +++ L Sbjct: 397 LHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDGLPRHF-IIQSLDNL 454 Query: 209 SEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVP-----LRCLE 263 Y+ E E F SIP L+ + ++P++++SG + ++R VP L + Sbjct: 455 --------YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVV----LHRAVPKDKWVLNHED 502 Query: 264 EHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP 304 G G+ G + GR R T+ V++ + LP Sbjct: 503 LVLGEQIGRGNFGEVFSGR----LRADNTLVAVKSCRETLP 539 >gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] Length = 822 Score = 60.8 bits (146), Expect = 5e-09 Identities = 49/161 (30%), Positives = 76/161 (47%), Gaps = 23/161 (14%) Query: 149 LRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRL 208 L WYHG IPR L+ GDFLVR+S +VL+ W L +HF I +++ L Sbjct: 455 LHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDGLPRHF-IIQSLDNL 512 Query: 209 SEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVP-----LRCLE 263 Y+ E E F SIP L+ + ++P++++SG + ++R VP L + Sbjct: 513 --------YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVV----LHRAVPKDKWVLNHED 560 Query: 264 EHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP 304 G G+ G + GR R T+ V++ + LP Sbjct: 561 LVLGEQIGRGNFGEVFSGR----LRADNTLVAVKSCRETLP 597 >gi|194239668 SHC (Src homology 2 domain containing) transforming protein 1 isoform 4 [Homo sapiens] Length = 473 Score = 59.7 bits (143), Expect = 1e-08 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%) Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178 S R + D P + L+ + + +E LR W+HG++ R+ +E L+Q +GDFLVR+ Sbjct: 343 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 402 Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236 S ++PG +VLT +H + V+R + F+S+ L+ ++ Sbjct: 403 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 451 Query: 237 NRRP-ISQQSGAIIFQPINR 255 N P IS S + QP+ R Sbjct: 452 NHLPIISAGSELCLQQPVER 471 >gi|194239664 SHC (Src homology 2 domain containing) transforming protein 1 isoform 3 [Homo sapiens] Length = 584 Score = 59.7 bits (143), Expect = 1e-08 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%) Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178 S R + D P + L+ + + +E LR W+HG++ R+ +E L+Q +GDFLVR+ Sbjct: 454 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 513 Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236 S ++PG +VLT +H + V+R + F+S+ L+ ++ Sbjct: 514 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 562 Query: 237 NRRP-ISQQSGAIIFQPINR 255 N P IS S + QP+ R Sbjct: 563 NHLPIISAGSELCLQQPVER 582 >gi|194239662 SHC (Src homology 2 domain containing) transforming protein 1 isoform 1 [Homo sapiens] Length = 583 Score = 59.7 bits (143), Expect = 1e-08 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%) Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178 S R + D P + L+ + + +E LR W+HG++ R+ +E L+Q +GDFLVR+ Sbjct: 453 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 512 Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236 S ++PG +VLT +H + V+R + F+S+ L+ ++ Sbjct: 513 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 561 Query: 237 NRRP-ISQQSGAIIFQPINR 255 N P IS S + QP+ R Sbjct: 562 NHLPIISAGSELCLQQPVER 581 >gi|32261324 SHC (Src homology 2 domain containing) transforming protein 1 isoform 2 [Homo sapiens] Length = 474 Score = 59.7 bits (143), Expect = 1e-08 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%) Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178 S R + D P + L+ + + +E LR W+HG++ R+ +E L+Q +GDFLVR+ Sbjct: 344 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 403 Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236 S ++PG +VLT +H + V+R + F+S+ L+ ++ Sbjct: 404 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 452 Query: 237 NRRP-ISQQSGAIIFQPINR 255 N P IS S + QP+ R Sbjct: 453 NHLPIISAGSELCLQQPVER 472 >gi|222446609 rai-like protein [Homo sapiens] Length = 630 Score = 58.5 bits (140), Expect = 2e-08 Identities = 37/110 (33%), Positives = 63/110 (57%), Gaps = 10/110 (9%) Query: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206 + L S YHG++ R+ +E+L+ +DGDFLVR+S +SPG +VL+ A+H L Sbjct: 519 QQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKH-------L 571 Query: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP-ISQQSGAIIFQPINR 255 L + +V+ + + FD++ L+R ++ N P IS S + QP+ + Sbjct: 572 LLVDPEGKVRTKDHV--FDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619 >gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo sapiens] Length = 217 Score = 55.5 bits (132), Expect = 2e-07 Identities = 24/59 (40%), Positives = 41/59 (69%), Gaps = 3/59 (5%) Query: 148 DLRSHAWYHGRIPRQVSENLVQR---DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINR 203 +++ H W+ G+IPR +E ++ + DG FL+R+S S+PG+F L+ ++ N QHFK+ R Sbjct: 54 EMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLR 112 >gi|5729856 GRB2-related adaptor protein [Homo sapiens] Length = 217 Score = 54.3 bits (129), Expect = 5e-07 Identities = 33/89 (37%), Positives = 50/89 (56%), Gaps = 11/89 (12%) Query: 149 LRSHAWYHGRIPRQVSENLVQRD---GDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205 ++ H WY GRI RQ++E ++ + G FL+R+S SSPG F ++ + + QHFK+ Sbjct: 55 VKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKV---- 110 Query: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCY 234 L EA + Y E F+S+ LV Y Sbjct: 111 --LREASGK--YFLWEEKFNSLNELVDFY 135 >gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [Homo sapiens] Length = 593 Score = 52.4 bits (124), Expect = 2e-06 Identities = 52/189 (27%), Positives = 84/189 (44%), Gaps = 23/189 (12%) Query: 78 SPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKE 137 S R+N VT IQ + G+ + E V++ E H + EK Sbjct: 44 SVRRNGAVTHIKIQNT------GDYYDLYGGEKFATLAELVQYYMEHH--GQLKEKNGDV 95 Query: 138 LEEELLLSSEDLRSHAWYHGRIPRQVSENLVQ---RDGDFLVRDSLSSPGNFVLTC---- 190 +E + L+ D S W+HG + + +E L+ + G FLVR+S S PG+FVL+ Sbjct: 96 IELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGD 155 Query: 191 -QWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAI- 248 + ++ K+ ++R E V E FDS+ LV Y + P+ + G + Sbjct: 156 DKGESNDGKSKVTHVMIRCQELKYDVG---GGERFDSLTDLVEHY--KKNPMVETLGTVL 210 Query: 249 -IFQPINRT 256 + QP+N T Sbjct: 211 QLKQPLNTT 219 Score = 46.6 bits (109), Expect = 9e-05 Identities = 38/140 (27%), Positives = 62/140 (44%), Gaps = 20/140 (14%) Query: 149 LRSHAWYHGRIPRQVSENLVQR---DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205 + S W+H I +ENL+ DG FL R S S+PG+F L+ + H KI T Sbjct: 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNT- 59 Query: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEE- 264 + Y + E F ++ LV+ Y+ + + +++G + I PL C + Sbjct: 60 ---GDYYD----LYGGEKFATLAELVQYYMEHHGQLKEKNGDV----IELKYPLNCADPT 108 Query: 265 ----HYGTSPGQAREGSLTK 280 +G G+ E LT+ Sbjct: 109 SERWFHGHLSGKEAEKLLTE 128 >gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] Length = 1167 Score = 52.0 bits (123), Expect = 2e-06 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%) Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204 L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210 >gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] Length = 1182 Score = 52.0 bits (123), Expect = 2e-06 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%) Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204 L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225 >gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] Length = 542 Score = 52.0 bits (123), Expect = 2e-06 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%) Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204 L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204 >gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] Length = 1064 Score = 52.0 bits (123), Expect = 2e-06 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%) Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204 L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210 >gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] Length = 1146 Score = 52.0 bits (123), Expect = 2e-06 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%) Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204 L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T Sbjct: 132 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189 >gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a [Homo sapiens] Length = 304 Score = 51.6 bits (122), Expect = 3e-06 Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 35/179 (19%) Query: 153 AWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSE 210 +WY GR+ RQ + L+Q R G FLVRDS +SPG++VL+ + H+ IN + R Sbjct: 12 SWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71 Query: 211 AYSRVQ---------YQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRC 261 S Q + + FDS+P L+ Y I + +P++R Sbjct: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY-----KIHYLDTTTLIEPVSR------ 120 Query: 262 LEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP--RGNLLRNKEKSGSQ 318 +R+GS R + A+ + E++LP +G++LR ++K Q Sbjct: 121 -----------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ 168 >gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b [Homo sapiens] Length = 204 Score = 51.6 bits (122), Expect = 3e-06 Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 35/179 (19%) Query: 153 AWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSE 210 +WY GR+ RQ + L+Q R G FLVRDS +SPG++VL+ + H+ IN + R Sbjct: 12 SWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71 Query: 211 AYSRVQ---------YQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRC 261 S Q + + FDS+P L+ Y I + +P++R Sbjct: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY-----KIHYLDTTTLIEPVSR------ 120 Query: 262 LEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP--RGNLLRNKEKSGSQ 318 +R+GS R + A+ + E++LP +G++LR ++K Q Sbjct: 121 -----------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ 168 >gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a [Homo sapiens] Length = 1130 Score = 49.3 bits (116), Expect = 1e-05 Identities = 22/56 (39%), Positives = 35/56 (62%), Gaps = 2/56 (3%) Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKIN 202 L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN Sbjct: 122 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN 177 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.132 0.395 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 35,051,640 Number of Sequences: 37866 Number of extensions: 1745194 Number of successful extensions: 6026 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 46 Number of HSP's successfully gapped in prelim test: 149 Number of HSP's that attempted gapping in prelim test: 5807 Number of HSP's gapped (non-prelim): 277 length of query: 825 length of database: 18,247,518 effective HSP length: 111 effective length of query: 714 effective length of database: 14,044,392 effective search space: 10027695888 effective search space used: 10027695888 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.