Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 4502371

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502371 breast cancer antiestrogen resistance 3 [Homo
sapiens]
         (825 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]    1674   0.0  
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]         554   e-157
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]        552   e-157
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]        548   e-156
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]        547   e-155
gi|208609985 SH2 domain containing 3A [Homo sapiens]                  363   e-100
gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens]        347   3e-95
gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens]        347   3e-95
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]      74   7e-13
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ...    62   3e-09
gi|169790811 SHC (Src homology 2 domain containing) transforming...    62   3e-09
gi|224586793 src homology 2 domain-containing transforming prote...    61   4e-09
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]          61   5e-09
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]            61   5e-09
gi|194239668 SHC (Src homology 2 domain containing) transforming...    60   1e-08
gi|194239664 SHC (Src homology 2 domain containing) transforming...    60   1e-08
gi|194239662 SHC (Src homology 2 domain containing) transforming...    60   1e-08
gi|32261324 SHC (Src homology 2 domain containing) transforming ...    60   1e-08
gi|222446609 rai-like protein [Homo sapiens]                           59   2e-08
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    55   2e-07
gi|5729856 GRB2-related adaptor protein [Homo sapiens]                 54   5e-07
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [...    52   2e-06
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]              52   2e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]                52   2e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]              52   2e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]              52   2e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]              52   2e-06
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ...    52   3e-06
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ...    52   3e-06
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...    49   1e-05

>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
          Length = 825

 Score = 1674 bits (4334), Expect = 0.0
 Identities = 825/825 (100%), Positives = 825/825 (100%)

Query: 1   MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP 60
           MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
Sbjct: 1   MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP 60

Query: 61  IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF 120
           IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
Sbjct: 61  IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF 120

Query: 121 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL 180
           SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
Sbjct: 121 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL 180

Query: 181 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP 240
           SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
Sbjct: 181 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP 240

Query: 241 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE 300
           ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
Sbjct: 241 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE 300

Query: 301 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC 360
           QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
Sbjct: 301 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC 360

Query: 361 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS 420
           PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
Sbjct: 361 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS 420

Query: 421 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD 480
           AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
Sbjct: 421 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD 480

Query: 481 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA 540
           DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
Sbjct: 481 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA 540

Query: 541 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE 600
           KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
Sbjct: 541 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE 600

Query: 601 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT 660
           RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
Sbjct: 601 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT 660

Query: 661 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ 720
           RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
Sbjct: 661 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ 720

Query: 721 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT 780
           AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
Sbjct: 721 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT 780

Query: 781 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
           EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
Sbjct: 781 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825


>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
          Length = 860

 Score =  554 bits (1428), Expect = e-157
 Identities = 331/752 (44%), Positives = 456/752 (60%), Gaps = 59/752 (7%)

Query: 86  TQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLS 145
           T D  +E P +D H E    R     +   +YVKFSKE++I+D +PEKL KELEEEL LS
Sbjct: 156 TGDVEEERPPRDVHSE----RAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLS 211

Query: 146 SEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205
           S DLRSHAWYHGRIPR+VSE LVQR+GDFL+RDSL+S G++VLTC+W+N A HFKIN+ V
Sbjct: 212 STDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVV 271

Query: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEH 265
           ++  E+Y+ +QY FE ESFD +P LVR +VG+R+ +S+QSGAII+ P+NRT PLR LE  
Sbjct: 272 VKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEAS 331

Query: 266 YGTSPGQAREGS-LTKGRPDVA--KRLSLTM-GGVQA----REQNLPRGNLL-RNKEKSG 316
           YG   G ++  S ++   P  +  KR S+TM  G+ A    R    P    L R ++   
Sbjct: 332 YGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIR 391

Query: 317 SQPACLDHMQDRRALSLKAHQSES---YLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPA 373
           S    +D + D  +      +S S   Y  +  ++    +    +  P SPV R  SEP 
Sbjct: 392 SCALSMDQIPDLHSPMSPISESPSSPAYSTV-TRVHAAPAAPSATALPASPVARRSSEPQ 450

Query: 374 LSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELN 433
           L P    +   ++  G     S S    K  P P     L   S P +      +YC+L 
Sbjct: 451 LCPGSAPKTHGESDKGP--HTSPSHTLGKASPSPS----LSSYSDPDS-----GHYCQLQ 499

Query: 434 PAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQ 493
           P       RG++  +  + S  +            R+ G           ER  E +   
Sbjct: 500 PPV-----RGSREWAATETSSQQA-----------RSYG-----------ERLKELSENG 532

Query: 494 MEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIA 553
             +G W K  F  P++E  SSF P  F+S  +P +N+PLE  +L++ KEL    D + +A
Sbjct: 533 APEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLA 591

Query: 554 QHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDI 613
           +HV  +DC VARILGV++EM+  MGV  G+EL+TLPHG QLRLD++ER +TM+I +AVDI
Sbjct: 592 RHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDI 651

Query: 614 LGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQY 673
           LGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M QI+RLE+TW  LR ++
Sbjct: 652 LGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRH 711

Query: 674 TQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKN 733
           T+ AILYEK+LKPF K L+EG+E    P +N + P ++PL+TL+E  +   EG + W   
Sbjct: 712 TEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLLECDSAPPEGPEPWGST 769

Query: 734 DQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGA 793
           +   E++L HL  AR +A     Y  NAE  L GFQ   E+ E+  TEFQMRLLWGS+GA
Sbjct: 770 EHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGA 829

Query: 794 QVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
             +Q  RYEKF+++LTALS KLE P V+ +EL
Sbjct: 830 SSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 860


>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
          Length = 703

 Score =  552 bits (1423), Expect = e-157
 Identities = 323/722 (44%), Positives = 445/722 (61%), Gaps = 55/722 (7%)

Query: 116 EYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFL 175
           +YVKFSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL
Sbjct: 25  DYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFL 84

Query: 176 VRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYV 235
           +RDSL+S G++VLTC+W+N A HFKIN+ V++  E+Y+ +QY FE ESFD +P LVR +V
Sbjct: 85  IRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHV 144

Query: 236 GNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLT 292
           G+R+ +S+QSGAII+ P+NRT PLR LE  YG   G ++  S ++   P  +  KR S+T
Sbjct: 145 GSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVT 204

Query: 293 M-GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLP 343
           M  G+ A    R    P    L R ++   S    +D + D  +      +S S   Y  
Sbjct: 205 MTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYST 264

Query: 344 IGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKP 403
           +  ++    +    +  P SPV R  SEP L P    +   ++  G     S S    K 
Sbjct: 265 V-TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKA 321

Query: 404 PPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQN 463
            P P     L   S P +      +YC+L P       RG++  +  + S  +       
Sbjct: 322 SPSPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA------ 361

Query: 464 EAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESK 523
                R+ G           ER  E +     +G W K  F  P++E  SSF P  F+S 
Sbjct: 362 -----RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSL 404

Query: 524 FLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGL 583
            +P +N+PLE  +L++ KEL    D + +A+HV  +DC VARILGV++EM+  MGV  G+
Sbjct: 405 LIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGM 464

Query: 584 ELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGD 643
           EL+TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+
Sbjct: 465 ELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGN 524

Query: 644 LYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPN 703
           ++SF+A+M AL+M QI+RLE+TW  LR ++T+ AILYEK+LKPF K L+EG+E    P +
Sbjct: 525 MFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLS 582

Query: 704 NVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAER 763
           N + P ++PL+TL+E  +   EG + W   +   E++L HL  AR +A     Y  NAE 
Sbjct: 583 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV 642

Query: 764 ILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQA 823
            L GFQ   E+ E+  TEFQMRLLWGS+GA  +Q  RYEKF+++LTALS KLE P V+ +
Sbjct: 643 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSS 701

Query: 824 EL 825
           EL
Sbjct: 702 EL 703


>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
          Length = 700

 Score =  548 bits (1413), Expect = e-156
 Identities = 321/721 (44%), Positives = 444/721 (61%), Gaps = 55/721 (7%)

Query: 117 YVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLV 176
           +V+FSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL+
Sbjct: 23  FVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI 82

Query: 177 RDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
           RDSL+S G++VLTC+W+N A HFKIN+ V++  E+Y+ +QY FE ESFD +P LVR +VG
Sbjct: 83  RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG 142

Query: 237 NRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLTM 293
           +R+ +S+QSGAII+ P+NRT PLR LE  YG   G ++  S ++   P  +  KR S+TM
Sbjct: 143 SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM 202

Query: 294 -GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLPI 344
             G+ A    R    P    L R ++   S    +D + D  +      +S S   Y  +
Sbjct: 203 TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV 262

Query: 345 GCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPP 404
             ++    +    +  P SPV R  SEP L P    +   ++  G     S S    K  
Sbjct: 263 -TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKAS 319

Query: 405 PKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNE 464
           P P     L   S P +      +YC+L P       RG++  +  + S  +        
Sbjct: 320 PSPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA------- 358

Query: 465 APGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKF 524
               R+ G           ER  E +     +G W K  F  P++E  SSF P  F+S  
Sbjct: 359 ----RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLL 402

Query: 525 LPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLE 584
           +P +N+PLE  +L++ KEL    D + +A+HV  +DC VARILGV++EM+  MGV  G+E
Sbjct: 403 IPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGME 462

Query: 585 LITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDL 644
           L+TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG++
Sbjct: 463 LLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNM 522

Query: 645 YSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNN 704
           +SF+A+M AL+M QI+RLE+TW  LR ++T+ AILYEK+LKPF K L+EG+E    P +N
Sbjct: 523 FSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSN 580

Query: 705 VSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERI 764
            + P ++PL+TL+E  +   EG + W   +   E++L HL  AR +A     Y  NAE  
Sbjct: 581 TTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVK 640

Query: 765 LAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAE 824
           L GFQ   E+ E+  TEFQMRLLWGS+GA  +Q  RYEKF+++LTALS KLE P V+ +E
Sbjct: 641 LQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSE 699

Query: 825 L 825
           L
Sbjct: 700 L 700


>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
          Length = 702

 Score =  547 bits (1410), Expect = e-155
 Identities = 321/720 (44%), Positives = 443/720 (61%), Gaps = 55/720 (7%)

Query: 118 VKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVR 177
           V+FSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL+R
Sbjct: 26  VQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIR 85

Query: 178 DSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGN 237
           DSL+S G++VLTC+W+N A HFKIN+ V++  E+Y+ +QY FE ESFD +P LVR +VG+
Sbjct: 86  DSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGS 145

Query: 238 RRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLTM- 293
           R+ +S+QSGAII+ P+NRT PLR LE  YG   G ++  S ++   P  +  KR S+TM 
Sbjct: 146 RKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMT 205

Query: 294 GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLPIG 345
            G+ A    R    P    L R ++   S    +D + D  +      +S S   Y  + 
Sbjct: 206 DGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV- 264

Query: 346 CKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPP 405
            ++    +    +  P SPV R  SEP L P    +   ++  G     S S    K  P
Sbjct: 265 TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKASP 322

Query: 406 KPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEA 465
            P     L   S P +      +YC+L P       RG++  +  + S  +         
Sbjct: 323 SPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA-------- 360

Query: 466 PGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFL 525
              R+ G           ER  E +     +G W K  F  P++E  SSF P  F+S  +
Sbjct: 361 ---RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLI 405

Query: 526 PPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLEL 585
           P +N+PLE  +L++ KEL    D + +A+HV  +DC VARILGV++EM+  MGV  G+EL
Sbjct: 406 PRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMEL 465

Query: 586 ITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLY 645
           +TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+++
Sbjct: 466 LTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMF 525

Query: 646 SFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNV 705
           SF+A+M AL+M QI+RLE+TW  LR ++T+ AILYEK+LKPF K L+EG+E    P +N 
Sbjct: 526 SFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSNT 583

Query: 706 SVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERIL 765
           + P ++PL+TL+E  +   EG + W   +   E++L HL  AR +A     Y  NAE  L
Sbjct: 584 TFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKL 643

Query: 766 AGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
            GFQ   E+ E+  TEFQMRLLWGS+GA  +Q  RYEKF+++LTALS KLE P V+ +EL
Sbjct: 644 QGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 702


>gi|208609985 SH2 domain containing 3A [Homo sapiens]
          Length = 576

 Score =  363 bits (933), Expect = e-100
 Identities = 244/674 (36%), Positives = 348/674 (51%), Gaps = 110/674 (16%)

Query: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206
           EDL    WYHG + RQ +E L+Q++GDFLVR S S  GN V++C+W+  A HF++ R  L
Sbjct: 8   EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67

Query: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHY 266
           R         +Q E E F SIP LV  Y+  RRP+SQ +GA++ +P+    PLR      
Sbjct: 68  RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLR------ 121

Query: 267 GTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQ 326
                   E +L  G   +                       LR ++ S SQPA L HM 
Sbjct: 122 ----RSFSEDTLMDGPARIEP---------------------LRARKWSNSQPADLAHMG 156

Query: 327 DRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPAL--SPAVVRRVSS 384
             R                       +G++ S  P S + RT S+P L  +PA +  V+ 
Sbjct: 157 RSRE--------------------DPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVA- 195

Query: 385 DARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGA 444
                ++LR SD QL  K P KP + P  ++P +          YCEL P          
Sbjct: 196 -----DSLRASDGQLQAKAPTKPPRTPSFELPDASER----PPTYCELVP---------- 236

Query: 445 KLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEF 504
           ++PS  QG      T+     P P               E PW  A    E+   +   F
Sbjct: 237 RVPS-VQG------TSPSQSCPEP---------------EAPWWEAEEDEEE---ENRCF 271

Query: 505 VTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVA 564
             P  E   SF P++  S  L P+N+PLE  +L   + LF  + P   A H+L +DC+  
Sbjct: 272 TRPQAEI--SFCPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQAT 329

Query: 565 RILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRA 624
            +LGV+ + R NMGVSSGLEL+TLPHGH LRL+++ERH T+A+  A+ +LGC+G LE+RA
Sbjct: 330 GLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERA 389

Query: 625 ATLSKIIQVAVELK-DSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQ 683
           A L  ++++A+ L+  + GDL   +A+M AL MPQ++RLE TW  LR  +T+ A+ +E++
Sbjct: 390 AALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQE 449

Query: 684 LKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNH 743
           LKP  + L EG    C  P  V++P + P+V L+       EG ++    D+SCE +L  
Sbjct: 450 LKPLMRALDEG-AGPC-DPGEVALPHVAPMVRLL-------EGEEVAGPLDESCERLLRT 500

Query: 744 LATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEK 803
           L  AR M   A  +R  A + L GF+P+ E+ E   T F  RLLWGS+GA   + ER+EK
Sbjct: 501 LHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEK 560

Query: 804 FNQILTALSRKLEP 817
           F ++L  LS++LEP
Sbjct: 561 FQRVLGVLSQRLEP 574


>gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens]
          Length = 506

 Score =  347 bits (889), Expect = 3e-95
 Identities = 202/468 (43%), Positives = 282/468 (60%), Gaps = 18/468 (3%)

Query: 358 SPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPS 417
           S  P+SP + T +    +PA     +  A +  A R S+ QLCP   PK          +
Sbjct: 57  SESPSSPAYSTVTRVHAAPAAPSATALPA-SPVARRSSEPQLCPGSAPKTHGESDKGPHT 115

Query: 418 SPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLI 477
           SPS  L   +    L+       G   +L    +GS      A +  +   R+ G     
Sbjct: 116 SPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSRE--WAATETSSQQARSYG----- 168

Query: 478 LDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAML 537
                 ER  E +     +G W K  F  P++E  SSF P  F+S  +P +N+PLE  +L
Sbjct: 169 ------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLL 221

Query: 538 KRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLD 597
           ++ KEL    D + +A+HV  +DC VARILGV++EM+  MGV  G+EL+TLPHG QLRLD
Sbjct: 222 RKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLD 281

Query: 598 IIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMP 657
           ++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M 
Sbjct: 282 LLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMA 341

Query: 658 QITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLM 717
           QI+RLE+TW  LR ++T+ AILYEK+LKPF K L+EG+E    P +N + P ++PL+TL+
Sbjct: 342 QISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLL 399

Query: 718 ERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEI 777
           E  +   EG + W   +   E++L HL  AR +A     Y  NAE  L GFQ   E+ E+
Sbjct: 400 ECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEV 459

Query: 778 CKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
             TEFQMRLLWGS+GA  +Q  RYEKF+++LTALS KLE P V+ +EL
Sbjct: 460 FSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 506


>gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens]
          Length = 506

 Score =  347 bits (889), Expect = 3e-95
 Identities = 202/468 (43%), Positives = 282/468 (60%), Gaps = 18/468 (3%)

Query: 358 SPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPS 417
           S  P+SP + T +    +PA     +  A +  A R S+ QLCP   PK          +
Sbjct: 57  SESPSSPAYSTVTRVHAAPAAPSATALPA-SPVARRSSEPQLCPGSAPKTHGESDKGPHT 115

Query: 418 SPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLI 477
           SPS  L   +    L+       G   +L    +GS      A +  +   R+ G     
Sbjct: 116 SPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSRE--WAATETSSQQARSYG----- 168

Query: 478 LDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAML 537
                 ER  E +     +G W K  F  P++E  SSF P  F+S  +P +N+PLE  +L
Sbjct: 169 ------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLL 221

Query: 538 KRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLD 597
           ++ KEL    D + +A+HV  +DC VARILGV++EM+  MGV  G+EL+TLPHG QLRLD
Sbjct: 222 RKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLD 281

Query: 598 IIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMP 657
           ++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M 
Sbjct: 282 LLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMA 341

Query: 658 QITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLM 717
           QI+RLE+TW  LR ++T+ AILYEK+LKPF K L+EG+E    P +N + P ++PL+TL+
Sbjct: 342 QISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLL 399

Query: 718 ERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEI 777
           E  +   EG + W   +   E++L HL  AR +A     Y  NAE  L GFQ   E+ E+
Sbjct: 400 ECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEV 459

Query: 778 CKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
             TEFQMRLLWGS+GA  +Q  RYEKF+++LTALS KLE P V+ +EL
Sbjct: 460 FSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 506


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 44/140 (31%), Positives = 71/140 (50%), Gaps = 14/140 (10%)

Query: 119 KFSKERHIMD---RTPEKL--KKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGD 173
           KF   RH +    R+P+       L + + +S + L    WYHG IPR  ++ L+++ GD
Sbjct: 420 KFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGD 479

Query: 174 FLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRC 233
           FLVR+S   PG +VL+       +HF I          Y    Y+FE   F +IP L+  
Sbjct: 480 FLVRESHGKPGEYVLSVYSDGQRRHFIIQ---------YVDNMYRFEGTGFSNIPQLIDH 530

Query: 234 YVGNRRPISQQSGAIIFQPI 253
           +   ++ I+++SG ++  PI
Sbjct: 531 HYTTKQVITKKSGVVLLNPI 550


>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
           sapiens]
          Length = 475

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 13/99 (13%)

Query: 145 SSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI--N 202
           + E LR   WYHGR+ R+ +E +++ DGDFLVRDS+++PG +VLT       +H  +   
Sbjct: 371 TEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDP 430

Query: 203 RTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI 241
             V+R  +             F+SI  L+  ++ N +PI
Sbjct: 431 EGVVRTKDVL-----------FESISHLIDHHLQNGQPI 458


>gi|169790811 SHC (Src homology 2 domain containing) transforming
           protein 2 [Homo sapiens]
          Length = 582

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 13/99 (13%)

Query: 145 SSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI--N 202
           + E LR   WYHGR+ R+ +E +++ DGDFLVRDS+++PG +VLT       +H  +   
Sbjct: 478 TEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDP 537

Query: 203 RTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI 241
             V+R  +             F+SI  L+  ++ N +PI
Sbjct: 538 EGVVRTKDVL-----------FESISHLIDHHLQNGQPI 565


>gi|224586793 src homology 2 domain-containing transforming protein
           C3 [Homo sapiens]
          Length = 594

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 10/110 (9%)

Query: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206
           E+L++  WY G + R+ +E L+++DGDFLVR S ++PG+FVLT      A+H       L
Sbjct: 492 EELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKH-------L 544

Query: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI-SQQSGAIIFQPINR 255
            L +    ++ +  +  FDSI  L+  ++ +  PI S  S   + QP+ R
Sbjct: 545 LLVDPEGTIRTKDRV--FDSISHLINHHLESSLPIVSAGSELCLQQPVER 592


>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
          Length = 764

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 49/161 (30%), Positives = 76/161 (47%), Gaps = 23/161 (14%)

Query: 149 LRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRL 208
           L    WYHG IPR     L+   GDFLVR+S      +VL+  W  L +HF I +++  L
Sbjct: 397 LHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDGLPRHF-IIQSLDNL 454

Query: 209 SEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVP-----LRCLE 263
                   Y+ E E F SIP L+   +  ++P++++SG +    ++R VP     L   +
Sbjct: 455 --------YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVV----LHRAVPKDKWVLNHED 502

Query: 264 EHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP 304
              G   G+   G +  GR     R   T+  V++  + LP
Sbjct: 503 LVLGEQIGRGNFGEVFSGR----LRADNTLVAVKSCRETLP 539


>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
          Length = 822

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 49/161 (30%), Positives = 76/161 (47%), Gaps = 23/161 (14%)

Query: 149 LRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRL 208
           L    WYHG IPR     L+   GDFLVR+S      +VL+  W  L +HF I +++  L
Sbjct: 455 LHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDGLPRHF-IIQSLDNL 512

Query: 209 SEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVP-----LRCLE 263
                   Y+ E E F SIP L+   +  ++P++++SG +    ++R VP     L   +
Sbjct: 513 --------YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVV----LHRAVPKDKWVLNHED 560

Query: 264 EHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP 304
              G   G+   G +  GR     R   T+  V++  + LP
Sbjct: 561 LVLGEQIGRGNFGEVFSGR----LRADNTLVAVKSCRETLP 597


>gi|194239668 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 4 [Homo sapiens]
          Length = 473

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)

Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178
           S  R + D  P  + L+     + +  +E LR   W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 343 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 402

Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
           S ++PG +VLT       +H  +     V+R  +             F+S+  L+  ++ 
Sbjct: 403 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 451

Query: 237 NRRP-ISQQSGAIIFQPINR 255
           N  P IS  S   + QP+ R
Sbjct: 452 NHLPIISAGSELCLQQPVER 471


>gi|194239664 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 3 [Homo sapiens]
          Length = 584

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)

Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178
           S  R + D  P  + L+     + +  +E LR   W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 454 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 513

Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
           S ++PG +VLT       +H  +     V+R  +             F+S+  L+  ++ 
Sbjct: 514 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 562

Query: 237 NRRP-ISQQSGAIIFQPINR 255
           N  P IS  S   + QP+ R
Sbjct: 563 NHLPIISAGSELCLQQPVER 582


>gi|194239662 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 1 [Homo sapiens]
          Length = 583

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)

Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178
           S  R + D  P  + L+     + +  +E LR   W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 453 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 512

Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
           S ++PG +VLT       +H  +     V+R  +             F+S+  L+  ++ 
Sbjct: 513 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 561

Query: 237 NRRP-ISQQSGAIIFQPINR 255
           N  P IS  S   + QP+ R
Sbjct: 562 NHLPIISAGSELCLQQPVER 581


>gi|32261324 SHC (Src homology 2 domain containing) transforming
           protein 1 isoform 2 [Homo sapiens]
          Length = 474

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)

Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178
           S  R + D  P  + L+     + +  +E LR   W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 344 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 403

Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
           S ++PG +VLT       +H  +     V+R  +             F+S+  L+  ++ 
Sbjct: 404 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 452

Query: 237 NRRP-ISQQSGAIIFQPINR 255
           N  P IS  S   + QP+ R
Sbjct: 453 NHLPIISAGSELCLQQPVER 472


>gi|222446609 rai-like protein [Homo sapiens]
          Length = 630

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 37/110 (33%), Positives = 63/110 (57%), Gaps = 10/110 (9%)

Query: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206
           + L S   YHG++ R+ +E+L+ +DGDFLVR+S +SPG +VL+      A+H       L
Sbjct: 519 QQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKH-------L 571

Query: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP-ISQQSGAIIFQPINR 255
            L +   +V+ +  +  FD++  L+R ++ N  P IS  S   + QP+ +
Sbjct: 572 LLVDPEGKVRTKDHV--FDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 24/59 (40%), Positives = 41/59 (69%), Gaps = 3/59 (5%)

Query: 148 DLRSHAWYHGRIPRQVSENLVQR---DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINR 203
           +++ H W+ G+IPR  +E ++ +   DG FL+R+S S+PG+F L+ ++ N  QHFK+ R
Sbjct: 54  EMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLR 112


>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
          Length = 217

 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 33/89 (37%), Positives = 50/89 (56%), Gaps = 11/89 (12%)

Query: 149 LRSHAWYHGRIPRQVSENLVQRD---GDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205
           ++ H WY GRI RQ++E ++ +    G FL+R+S SSPG F ++  + +  QHFK+    
Sbjct: 55  VKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKV---- 110

Query: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCY 234
             L EA  +  Y    E F+S+  LV  Y
Sbjct: 111 --LREASGK--YFLWEEKFNSLNELVDFY 135


>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
           [Homo sapiens]
          Length = 593

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 52/189 (27%), Positives = 84/189 (44%), Gaps = 23/189 (12%)

Query: 78  SPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKE 137
           S R+N  VT   IQ +      G+ +            E V++  E H   +  EK    
Sbjct: 44  SVRRNGAVTHIKIQNT------GDYYDLYGGEKFATLAELVQYYMEHH--GQLKEKNGDV 95

Query: 138 LEEELLLSSEDLRSHAWYHGRIPRQVSENLVQ---RDGDFLVRDSLSSPGNFVLTC---- 190
           +E +  L+  D  S  W+HG +  + +E L+    + G FLVR+S S PG+FVL+     
Sbjct: 96  IELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGD 155

Query: 191 -QWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAI- 248
            + ++     K+   ++R  E    V      E FDS+  LV  Y   + P+ +  G + 
Sbjct: 156 DKGESNDGKSKVTHVMIRCQELKYDVG---GGERFDSLTDLVEHY--KKNPMVETLGTVL 210

Query: 249 -IFQPINRT 256
            + QP+N T
Sbjct: 211 QLKQPLNTT 219



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 38/140 (27%), Positives = 62/140 (44%), Gaps = 20/140 (14%)

Query: 149 LRSHAWYHGRIPRQVSENLVQR---DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205
           + S  W+H  I    +ENL+     DG FL R S S+PG+F L+ +      H KI  T 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNT- 59

Query: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEE- 264
               + Y      +  E F ++  LV+ Y+ +   + +++G +    I    PL C +  
Sbjct: 60  ---GDYYD----LYGGEKFATLAELVQYYMEHHGQLKEKNGDV----IELKYPLNCADPT 108

Query: 265 ----HYGTSPGQAREGSLTK 280
                +G   G+  E  LT+
Sbjct: 109 SERWFHGHLSGKEAEKLLTE 128


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)

Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
           L  H+WYHG + R  +E L+    +G FLVR+S SSPG   ++ +++    H++IN T
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)

Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
           L  H+WYHG + R  +E L+    +G FLVR+S SSPG   ++ +++    H++IN T
Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)

Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
           L  H+WYHG + R  +E L+    +G FLVR+S SSPG   ++ +++    H++IN T
Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)

Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
           L  H+WYHG + R  +E L+    +G FLVR+S SSPG   ++ +++    H++IN T
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)

Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
           L  H+WYHG + R  +E L+    +G FLVR+S SSPG   ++ +++    H++IN T
Sbjct: 132 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189


>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
           [Homo sapiens]
          Length = 304

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 35/179 (19%)

Query: 153 AWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSE 210
           +WY GR+ RQ +  L+Q  R G FLVRDS +SPG++VL+    +   H+ IN +  R   
Sbjct: 12  SWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71

Query: 211 AYSRVQ---------YQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRC 261
             S  Q          +   + FDS+P L+  Y      I       + +P++R      
Sbjct: 72  PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY-----KIHYLDTTTLIEPVSR------ 120

Query: 262 LEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP--RGNLLRNKEKSGSQ 318
                      +R+GS    R + A+ +          E++LP  +G++LR ++K   Q
Sbjct: 121 -----------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ 168


>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
           [Homo sapiens]
          Length = 204

 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 35/179 (19%)

Query: 153 AWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSE 210
           +WY GR+ RQ +  L+Q  R G FLVRDS +SPG++VL+    +   H+ IN +  R   
Sbjct: 12  SWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71

Query: 211 AYSRVQ---------YQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRC 261
             S  Q          +   + FDS+P L+  Y      I       + +P++R      
Sbjct: 72  PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY-----KIHYLDTTTLIEPVSR------ 120

Query: 262 LEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP--RGNLLRNKEKSGSQ 318
                      +R+GS    R + A+ +          E++LP  +G++LR ++K   Q
Sbjct: 121 -----------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ 168


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 22/56 (39%), Positives = 35/56 (62%), Gaps = 2/56 (3%)

Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKIN 202
           L  H+WYHG + R  +E L+    +G FLVR+S SSPG   ++ +++    H++IN
Sbjct: 122 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,051,640
Number of Sequences: 37866
Number of extensions: 1745194
Number of successful extensions: 6026
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 5807
Number of HSP's gapped (non-prelim): 277
length of query: 825
length of database: 18,247,518
effective HSP length: 111
effective length of query: 714
effective length of database: 14,044,392
effective search space: 10027695888
effective search space used: 10027695888
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press