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Search of human proteins with 4502371
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502371 breast cancer antiestrogen resistance 3 [Homo
sapiens]
(825 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 1674 0.0
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens] 554 e-157
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens] 552 e-157
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens] 548 e-156
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens] 547 e-155
gi|208609985 SH2 domain containing 3A [Homo sapiens] 363 e-100
gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens] 347 3e-95
gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens] 347 3e-95
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 74 7e-13
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 62 3e-09
gi|169790811 SHC (Src homology 2 domain containing) transforming... 62 3e-09
gi|224586793 src homology 2 domain-containing transforming prote... 61 4e-09
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 61 5e-09
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 61 5e-09
gi|194239668 SHC (Src homology 2 domain containing) transforming... 60 1e-08
gi|194239664 SHC (Src homology 2 domain containing) transforming... 60 1e-08
gi|194239662 SHC (Src homology 2 domain containing) transforming... 60 1e-08
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 60 1e-08
gi|222446609 rai-like protein [Homo sapiens] 59 2e-08
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 55 2e-07
gi|5729856 GRB2-related adaptor protein [Homo sapiens] 54 5e-07
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 52 2e-06
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 52 2e-06
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 52 2e-06
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 52 2e-06
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 52 2e-06
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 52 2e-06
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 52 3e-06
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 52 3e-06
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 49 1e-05
>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
Length = 825
Score = 1674 bits (4334), Expect = 0.0
Identities = 825/825 (100%), Positives = 825/825 (100%)
Query: 1 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP 60
MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
Sbjct: 1 MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP 60
Query: 61 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF 120
IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
Sbjct: 61 IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF 120
Query: 121 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL 180
SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
Sbjct: 121 SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL 180
Query: 181 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP 240
SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
Sbjct: 181 SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP 240
Query: 241 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE 300
ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
Sbjct: 241 ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE 300
Query: 301 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC 360
QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
Sbjct: 301 QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC 360
Query: 361 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS 420
PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
Sbjct: 361 PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS 420
Query: 421 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD 480
AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
Sbjct: 421 AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD 480
Query: 481 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA 540
DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
Sbjct: 481 DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA 540
Query: 541 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE 600
KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
Sbjct: 541 KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE 600
Query: 601 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT 660
RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
Sbjct: 601 RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT 660
Query: 661 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ 720
RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
Sbjct: 661 RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ 720
Query: 721 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT 780
AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
Sbjct: 721 AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT 780
Query: 781 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL
Sbjct: 781 EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
Length = 860
Score = 554 bits (1428), Expect = e-157
Identities = 331/752 (44%), Positives = 456/752 (60%), Gaps = 59/752 (7%)
Query: 86 TQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLS 145
T D +E P +D H E R + +YVKFSKE++I+D +PEKL KELEEEL LS
Sbjct: 156 TGDVEEERPPRDVHSE----RAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLS 211
Query: 146 SEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205
S DLRSHAWYHGRIPR+VSE LVQR+GDFL+RDSL+S G++VLTC+W+N A HFKIN+ V
Sbjct: 212 STDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVV 271
Query: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEH 265
++ E+Y+ +QY FE ESFD +P LVR +VG+R+ +S+QSGAII+ P+NRT PLR LE
Sbjct: 272 VKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEAS 331
Query: 266 YGTSPGQAREGS-LTKGRPDVA--KRLSLTM-GGVQA----REQNLPRGNLL-RNKEKSG 316
YG G ++ S ++ P + KR S+TM G+ A R P L R ++
Sbjct: 332 YGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIR 391
Query: 317 SQPACLDHMQDRRALSLKAHQSES---YLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPA 373
S +D + D + +S S Y + ++ + + P SPV R SEP
Sbjct: 392 SCALSMDQIPDLHSPMSPISESPSSPAYSTV-TRVHAAPAAPSATALPASPVARRSSEPQ 450
Query: 374 LSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELN 433
L P + ++ G S S K P P L S P + +YC+L
Sbjct: 451 LCPGSAPKTHGESDKGP--HTSPSHTLGKASPSPS----LSSYSDPDS-----GHYCQLQ 499
Query: 434 PAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQ 493
P RG++ + + S + R+ G ER E +
Sbjct: 500 PPV-----RGSREWAATETSSQQA-----------RSYG-----------ERLKELSENG 532
Query: 494 MEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIA 553
+G W K F P++E SSF P F+S +P +N+PLE +L++ KEL D + +A
Sbjct: 533 APEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLA 591
Query: 554 QHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDI 613
+HV +DC VARILGV++EM+ MGV G+EL+TLPHG QLRLD++ER +TM+I +AVDI
Sbjct: 592 RHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDI 651
Query: 614 LGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQITRLEKTWTALRHQY 673
LGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M QI+RLE+TW LR ++
Sbjct: 652 LGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRH 711
Query: 674 TQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKN 733
T+ AILYEK+LKPF K L+EG+E P +N + P ++PL+TL+E + EG + W
Sbjct: 712 TEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLLECDSAPPEGPEPWGST 769
Query: 734 DQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGA 793
+ E++L HL AR +A Y NAE L GFQ E+ E+ TEFQMRLLWGS+GA
Sbjct: 770 EHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGA 829
Query: 794 QVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
+Q RYEKF+++LTALS KLE P V+ +EL
Sbjct: 830 SSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 860
>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
Length = 703
Score = 552 bits (1423), Expect = e-157
Identities = 323/722 (44%), Positives = 445/722 (61%), Gaps = 55/722 (7%)
Query: 116 EYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFL 175
+YVKFSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL
Sbjct: 25 DYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFL 84
Query: 176 VRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYV 235
+RDSL+S G++VLTC+W+N A HFKIN+ V++ E+Y+ +QY FE ESFD +P LVR +V
Sbjct: 85 IRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHV 144
Query: 236 GNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLT 292
G+R+ +S+QSGAII+ P+NRT PLR LE YG G ++ S ++ P + KR S+T
Sbjct: 145 GSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVT 204
Query: 293 M-GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLP 343
M G+ A R P L R ++ S +D + D + +S S Y
Sbjct: 205 MTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYST 264
Query: 344 IGCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKP 403
+ ++ + + P SPV R SEP L P + ++ G S S K
Sbjct: 265 V-TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKA 321
Query: 404 PPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQN 463
P P L S P + +YC+L P RG++ + + S +
Sbjct: 322 SPSPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA------ 361
Query: 464 EAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESK 523
R+ G ER E + +G W K F P++E SSF P F+S
Sbjct: 362 -----RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSL 404
Query: 524 FLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGL 583
+P +N+PLE +L++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+
Sbjct: 405 LIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGM 464
Query: 584 ELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGD 643
EL+TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+
Sbjct: 465 ELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGN 524
Query: 644 LYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPN 703
++SF+A+M AL+M QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P +
Sbjct: 525 MFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLS 582
Query: 704 NVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAER 763
N + P ++PL+TL+E + EG + W + E++L HL AR +A Y NAE
Sbjct: 583 NTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEV 642
Query: 764 ILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQA 823
L GFQ E+ E+ TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ +
Sbjct: 643 KLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSS 701
Query: 824 EL 825
EL
Sbjct: 702 EL 703
>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
Length = 700
Score = 548 bits (1413), Expect = e-156
Identities = 321/721 (44%), Positives = 444/721 (61%), Gaps = 55/721 (7%)
Query: 117 YVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLV 176
+V+FSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL+
Sbjct: 23 FVQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLI 82
Query: 177 RDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
RDSL+S G++VLTC+W+N A HFKIN+ V++ E+Y+ +QY FE ESFD +P LVR +VG
Sbjct: 83 RDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVG 142
Query: 237 NRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLTM 293
+R+ +S+QSGAII+ P+NRT PLR LE YG G ++ S ++ P + KR S+TM
Sbjct: 143 SRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTM 202
Query: 294 -GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLPI 344
G+ A R P L R ++ S +D + D + +S S Y +
Sbjct: 203 TDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV 262
Query: 345 GCKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPP 404
++ + + P SPV R SEP L P + ++ G S S K
Sbjct: 263 -TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKAS 319
Query: 405 PKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNE 464
P P L S P + +YC+L P RG++ + + S +
Sbjct: 320 PSPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA------- 358
Query: 465 APGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKF 524
R+ G ER E + +G W K F P++E SSF P F+S
Sbjct: 359 ----RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLL 402
Query: 525 LPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLE 584
+P +N+PLE +L++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+E
Sbjct: 403 IPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGME 462
Query: 585 LITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDL 644
L+TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG++
Sbjct: 463 LLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNM 522
Query: 645 YSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNN 704
+SF+A+M AL+M QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P +N
Sbjct: 523 FSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSN 580
Query: 705 VSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERI 764
+ P ++PL+TL+E + EG + W + E++L HL AR +A Y NAE
Sbjct: 581 TTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVK 640
Query: 765 LAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAE 824
L GFQ E+ E+ TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ +E
Sbjct: 641 LQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSE 699
Query: 825 L 825
L
Sbjct: 700 L 700
>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
Length = 702
Score = 547 bits (1410), Expect = e-155
Identities = 321/720 (44%), Positives = 443/720 (61%), Gaps = 55/720 (7%)
Query: 118 VKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVR 177
V+FSKE++I+D +PEKL KELEEEL LSS DLRSHAWYHGRIPR+VSE LVQR+GDFL+R
Sbjct: 26 VQFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIR 85
Query: 178 DSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGN 237
DSL+S G++VLTC+W+N A HFKIN+ V++ E+Y+ +QY FE ESFD +P LVR +VG+
Sbjct: 86 DSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGS 145
Query: 238 RRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGS-LTKGRPDVA--KRLSLTM- 293
R+ +S+QSGAII+ P+NRT PLR LE YG G ++ S ++ P + KR S+TM
Sbjct: 146 RKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMT 205
Query: 294 GGVQA----REQNLPRGNLL-RNKEKSGSQPACLDHMQDRRALSLKAHQSES---YLPIG 345
G+ A R P L R ++ S +D + D + +S S Y +
Sbjct: 206 DGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTV- 264
Query: 346 CKLPPQSSGVDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPP 405
++ + + P SPV R SEP L P + ++ G S S K P
Sbjct: 265 TRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGP--HTSPSHTLGKASP 322
Query: 406 KPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEA 465
P L S P + +YC+L P RG++ + + S +
Sbjct: 323 SPS----LSSYSDPDS-----GHYCQLQPPV-----RGSREWAATETSSQQA-------- 360
Query: 466 PGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFL 525
R+ G ER E + +G W K F P++E SSF P F+S +
Sbjct: 361 ---RSYG-----------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLI 405
Query: 526 PPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLEL 585
P +N+PLE +L++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+EL
Sbjct: 406 PRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMEL 465
Query: 586 ITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLY 645
+TLPHG QLRLD++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+++
Sbjct: 466 LTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMF 525
Query: 646 SFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNV 705
SF+A+M AL+M QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P +N
Sbjct: 526 SFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSNT 583
Query: 706 SVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERIL 765
+ P ++PL+TL+E + EG + W + E++L HL AR +A Y NAE L
Sbjct: 584 TFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKL 643
Query: 766 AGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
GFQ E+ E+ TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ +EL
Sbjct: 644 QGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 702
>gi|208609985 SH2 domain containing 3A [Homo sapiens]
Length = 576
Score = 363 bits (933), Expect = e-100
Identities = 244/674 (36%), Positives = 348/674 (51%), Gaps = 110/674 (16%)
Query: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206
EDL WYHG + RQ +E L+Q++GDFLVR S S GN V++C+W+ A HF++ R L
Sbjct: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
Query: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHY 266
R +Q E E F SIP LV Y+ RRP+SQ +GA++ +P+ PLR
Sbjct: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLR------ 121
Query: 267 GTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPACLDHMQ 326
E +L G + LR ++ S SQPA L HM
Sbjct: 122 ----RSFSEDTLMDGPARIEP---------------------LRARKWSNSQPADLAHMG 156
Query: 327 DRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPCPNSPVFRTGSEPAL--SPAVVRRVSS 384
R +G++ S P S + RT S+P L +PA + V+
Sbjct: 157 RSRE--------------------DPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVA- 195
Query: 385 DARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPSAWLNSEANYCELNPAFATGCGRGA 444
++LR SD QL K P KP + P ++P + YCEL P
Sbjct: 196 -----DSLRASDGQLQAKAPTKPPRTPSFELPDASER----PPTYCELVP---------- 236
Query: 445 KLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEF 504
++PS QG T+ P P E PW A E+ + F
Sbjct: 237 RVPS-VQG------TSPSQSCPEP---------------EAPWWEAEEDEEE---ENRCF 271
Query: 505 VTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVA 564
P E SF P++ S L P+N+PLE +L + LF + P A H+L +DC+
Sbjct: 272 TRPQAEI--SFCPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQAT 329
Query: 565 RILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIERHNTMAIGIAVDILGCTGTLEDRA 624
+LGV+ + R NMGVSSGLEL+TLPHGH LRL+++ERH T+A+ A+ +LGC+G LE+RA
Sbjct: 330 GLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERA 389
Query: 625 ATLSKIIQVAVELK-DSMGDLYSFSALMKALEMPQITRLEKTWTALRHQYTQTAILYEKQ 683
A L ++++A+ L+ + GDL +A+M AL MPQ++RLE TW LR +T+ A+ +E++
Sbjct: 390 AALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQE 449
Query: 684 LKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQAVTFEGTDMWEKNDQSCEIMLNH 743
LKP + L EG C P V++P + P+V L+ EG ++ D+SCE +L
Sbjct: 450 LKPLMRALDEG-AGPC-DPGEVALPHVAPMVRLL-------EGEEVAGPLDESCERLLRT 500
Query: 744 LATARFMAEAADSYRMNAERILAGFQPDEEMNEICKTEFQMRLLWGSKGAQVNQTERYEK 803
L AR M A +R A + L GF+P+ E+ E T F RLLWGS+GA + ER+EK
Sbjct: 501 LHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEK 560
Query: 804 FNQILTALSRKLEP 817
F ++L LS++LEP
Sbjct: 561 FQRVLGVLSQRLEP 574
>gi|216547779 SH2 domain containing 3C isoform c [Homo sapiens]
Length = 506
Score = 347 bits (889), Expect = 3e-95
Identities = 202/468 (43%), Positives = 282/468 (60%), Gaps = 18/468 (3%)
Query: 358 SPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPS 417
S P+SP + T + +PA + A + A R S+ QLCP PK +
Sbjct: 57 SESPSSPAYSTVTRVHAAPAAPSATALPA-SPVARRSSEPQLCPGSAPKTHGESDKGPHT 115
Query: 418 SPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLI 477
SPS L + L+ G +L +GS A + + R+ G
Sbjct: 116 SPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSRE--WAATETSSQQARSYG----- 168
Query: 478 LDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAML 537
ER E + +G W K F P++E SSF P F+S +P +N+PLE +L
Sbjct: 169 ------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLL 221
Query: 538 KRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLD 597
++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+EL+TLPHG QLRLD
Sbjct: 222 RKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLD 281
Query: 598 IIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMP 657
++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M
Sbjct: 282 LLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMA 341
Query: 658 QITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLM 717
QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P +N + P ++PL+TL+
Sbjct: 342 QISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLL 399
Query: 718 ERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEI 777
E + EG + W + E++L HL AR +A Y NAE L GFQ E+ E+
Sbjct: 400 ECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEV 459
Query: 778 CKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ +EL
Sbjct: 460 FSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 506
>gi|216547769 SH2 domain containing 3C isoform c [Homo sapiens]
Length = 506
Score = 347 bits (889), Expect = 3e-95
Identities = 202/468 (43%), Positives = 282/468 (60%), Gaps = 18/468 (3%)
Query: 358 SPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPS 417
S P+SP + T + +PA + A + A R S+ QLCP PK +
Sbjct: 57 SESPSSPAYSTVTRVHAAPAAPSATALPA-SPVARRSSEPQLCPGSAPKTHGESDKGPHT 115
Query: 418 SPSAWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLI 477
SPS L + L+ G +L +GS A + + R+ G
Sbjct: 116 SPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSRE--WAATETSSQQARSYG----- 168
Query: 478 LDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAML 537
ER E + +G W K F P++E SSF P F+S +P +N+PLE +L
Sbjct: 169 ------ERLKELSENGAPEGDWGK-TFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLL 221
Query: 538 KRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLD 597
++ KEL D + +A+HV +DC VARILGV++EM+ MGV G+EL+TLPHG QLRLD
Sbjct: 222 RKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLD 281
Query: 598 IIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMP 657
++ER +TM+I +AVDILGCTG+ E+RAA L K IQ+A EL+ +MG+++SF+A+M AL+M
Sbjct: 282 LLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMA 341
Query: 658 QITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLM 717
QI+RLE+TW LR ++T+ AILYEK+LKPF K L+EG+E P +N + P ++PL+TL+
Sbjct: 342 QISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGP--PLSNTTFPHVLPLITLL 399
Query: 718 ERQAVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEI 777
E + EG + W + E++L HL AR +A Y NAE L GFQ E+ E+
Sbjct: 400 ECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEV 459
Query: 778 CKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL 825
TEFQMRLLWGS+GA +Q RYEKF+++LTALS KLE P V+ +EL
Sbjct: 460 FSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLE-PAVRSSEL 506
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 73.6 bits (179), Expect = 7e-13
Identities = 44/140 (31%), Positives = 71/140 (50%), Gaps = 14/140 (10%)
Query: 119 KFSKERHIMD---RTPEKL--KKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGD 173
KF RH + R+P+ L + + +S + L WYHG IPR ++ L+++ GD
Sbjct: 420 KFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGD 479
Query: 174 FLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRC 233
FLVR+S PG +VL+ +HF I Y Y+FE F +IP L+
Sbjct: 480 FLVRESHGKPGEYVLSVYSDGQRRHFIIQ---------YVDNMYRFEGTGFSNIPQLIDH 530
Query: 234 YVGNRRPISQQSGAIIFQPI 253
+ ++ I+++SG ++ PI
Sbjct: 531 HYTTKQVITKKSGVVLLNPI 550
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 61.6 bits (148), Expect = 3e-09
Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 13/99 (13%)
Query: 145 SSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI--N 202
+ E LR WYHGR+ R+ +E +++ DGDFLVRDS+++PG +VLT +H +
Sbjct: 371 TEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDP 430
Query: 203 RTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI 241
V+R + F+SI L+ ++ N +PI
Sbjct: 431 EGVVRTKDVL-----------FESISHLIDHHLQNGQPI 458
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 61.6 bits (148), Expect = 3e-09
Identities = 34/99 (34%), Positives = 54/99 (54%), Gaps = 13/99 (13%)
Query: 145 SSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKI--N 202
+ E LR WYHGR+ R+ +E +++ DGDFLVRDS+++PG +VLT +H +
Sbjct: 478 TEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDP 537
Query: 203 RTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI 241
V+R + F+SI L+ ++ N +PI
Sbjct: 538 EGVVRTKDVL-----------FESISHLIDHHLQNGQPI 565
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 61.2 bits (147), Expect = 4e-09
Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 10/110 (9%)
Query: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206
E+L++ WY G + R+ +E L+++DGDFLVR S ++PG+FVLT A+H L
Sbjct: 492 EELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKH-------L 544
Query: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI-SQQSGAIIFQPINR 255
L + ++ + + FDSI L+ ++ + PI S S + QP+ R
Sbjct: 545 LLVDPEGTIRTKDRV--FDSISHLINHHLESSLPIVSAGSELCLQQPVER 592
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 60.8 bits (146), Expect = 5e-09
Identities = 49/161 (30%), Positives = 76/161 (47%), Gaps = 23/161 (14%)
Query: 149 LRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRL 208
L WYHG IPR L+ GDFLVR+S +VL+ W L +HF I +++ L
Sbjct: 397 LHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDGLPRHF-IIQSLDNL 454
Query: 209 SEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVP-----LRCLE 263
Y+ E E F SIP L+ + ++P++++SG + ++R VP L +
Sbjct: 455 --------YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVV----LHRAVPKDKWVLNHED 502
Query: 264 EHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP 304
G G+ G + GR R T+ V++ + LP
Sbjct: 503 LVLGEQIGRGNFGEVFSGR----LRADNTLVAVKSCRETLP 539
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 60.8 bits (146), Expect = 5e-09
Identities = 49/161 (30%), Positives = 76/161 (47%), Gaps = 23/161 (14%)
Query: 149 LRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRL 208
L WYHG IPR L+ GDFLVR+S +VL+ W L +HF I +++ L
Sbjct: 455 LHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDGLPRHF-IIQSLDNL 512
Query: 209 SEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVP-----LRCLE 263
Y+ E E F SIP L+ + ++P++++SG + ++R VP L +
Sbjct: 513 --------YRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVV----LHRAVPKDKWVLNHED 560
Query: 264 EHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP 304
G G+ G + GR R T+ V++ + LP
Sbjct: 561 LVLGEQIGRGNFGEVFSGR----LRADNTLVAVKSCRETLP 597
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)
Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178
S R + D P + L+ + + +E LR W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 343 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 402
Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
S ++PG +VLT +H + V+R + F+S+ L+ ++
Sbjct: 403 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 451
Query: 237 NRRP-ISQQSGAIIFQPINR 255
N P IS S + QP+ R
Sbjct: 452 NHLPIISAGSELCLQQPVER 471
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)
Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178
S R + D P + L+ + + +E LR W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 454 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 513
Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
S ++PG +VLT +H + V+R + F+S+ L+ ++
Sbjct: 514 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 562
Query: 237 NRRP-ISQQSGAIIFQPINR 255
N P IS S + QP+ R
Sbjct: 563 NHLPIISAGSELCLQQPVER 582
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)
Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178
S R + D P + L+ + + +E LR W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 453 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 512
Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
S ++PG +VLT +H + V+R + F+S+ L+ ++
Sbjct: 513 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 561
Query: 237 NRRP-ISQQSGAIIFQPINR 255
N P IS S + QP+ R
Sbjct: 562 NHLPIISAGSELCLQQPVER 581
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/140 (29%), Positives = 69/140 (49%), Gaps = 16/140 (11%)
Query: 121 SKERHIMDRTP--EKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRD 178
S R + D P + L+ + + +E LR W+HG++ R+ +E L+Q +GDFLVR+
Sbjct: 344 SAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRE 403
Query: 179 SLSSPGNFVLTCQWKNLAQHFKI--NRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVG 236
S ++PG +VLT +H + V+R + F+S+ L+ ++
Sbjct: 404 STTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKD-----------HRFESVSHLISYHMD 452
Query: 237 NRRP-ISQQSGAIIFQPINR 255
N P IS S + QP+ R
Sbjct: 453 NHLPIISAGSELCLQQPVER 472
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/110 (33%), Positives = 63/110 (57%), Gaps = 10/110 (9%)
Query: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206
+ L S YHG++ R+ +E+L+ +DGDFLVR+S +SPG +VL+ A+H L
Sbjct: 519 QQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKH-------L 571
Query: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP-ISQQSGAIIFQPINR 255
L + +V+ + + FD++ L+R ++ N P IS S + QP+ +
Sbjct: 572 LLVDPEGKVRTKDHV--FDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 55.5 bits (132), Expect = 2e-07
Identities = 24/59 (40%), Positives = 41/59 (69%), Gaps = 3/59 (5%)
Query: 148 DLRSHAWYHGRIPRQVSENLVQR---DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINR 203
+++ H W+ G+IPR +E ++ + DG FL+R+S S+PG+F L+ ++ N QHFK+ R
Sbjct: 54 EMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLR 112
>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
Length = 217
Score = 54.3 bits (129), Expect = 5e-07
Identities = 33/89 (37%), Positives = 50/89 (56%), Gaps = 11/89 (12%)
Query: 149 LRSHAWYHGRIPRQVSENLVQRD---GDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205
++ H WY GRI RQ++E ++ + G FL+R+S SSPG F ++ + + QHFK+
Sbjct: 55 VKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKV---- 110
Query: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCY 234
L EA + Y E F+S+ LV Y
Sbjct: 111 --LREASGK--YFLWEEKFNSLNELVDFY 135
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 52.4 bits (124), Expect = 2e-06
Identities = 52/189 (27%), Positives = 84/189 (44%), Gaps = 23/189 (12%)
Query: 78 SPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKE 137
S R+N VT IQ + G+ + E V++ E H + EK
Sbjct: 44 SVRRNGAVTHIKIQNT------GDYYDLYGGEKFATLAELVQYYMEHH--GQLKEKNGDV 95
Query: 138 LEEELLLSSEDLRSHAWYHGRIPRQVSENLVQ---RDGDFLVRDSLSSPGNFVLTC---- 190
+E + L+ D S W+HG + + +E L+ + G FLVR+S S PG+FVL+
Sbjct: 96 IELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGD 155
Query: 191 -QWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAI- 248
+ ++ K+ ++R E V E FDS+ LV Y + P+ + G +
Sbjct: 156 DKGESNDGKSKVTHVMIRCQELKYDVG---GGERFDSLTDLVEHY--KKNPMVETLGTVL 210
Query: 249 -IFQPINRT 256
+ QP+N T
Sbjct: 211 QLKQPLNTT 219
Score = 46.6 bits (109), Expect = 9e-05
Identities = 38/140 (27%), Positives = 62/140 (44%), Gaps = 20/140 (14%)
Query: 149 LRSHAWYHGRIPRQVSENLVQR---DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTV 205
+ S W+H I +ENL+ DG FL R S S+PG+F L+ + H KI T
Sbjct: 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNT- 59
Query: 206 LRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEE- 264
+ Y + E F ++ LV+ Y+ + + +++G + I PL C +
Sbjct: 60 ---GDYYD----LYGGEKFATLAELVQYYMEHHGQLKEKNGDV----IELKYPLNCADPT 108
Query: 265 ----HYGTSPGQAREGSLTK 280
+G G+ E LT+
Sbjct: 109 SERWFHGHLSGKEAEKLLTE 128
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T
Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T
Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/58 (39%), Positives = 36/58 (62%), Gaps = 2/58 (3%)
Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRT 204
L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN T
Sbjct: 132 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 35/179 (19%)
Query: 153 AWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSE 210
+WY GR+ RQ + L+Q R G FLVRDS +SPG++VL+ + H+ IN + R
Sbjct: 12 SWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71
Query: 211 AYSRVQ---------YQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRC 261
S Q + + FDS+P L+ Y I + +P++R
Sbjct: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY-----KIHYLDTTTLIEPVSR------ 120
Query: 262 LEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP--RGNLLRNKEKSGSQ 318
+R+GS R + A+ + E++LP +G++LR ++K Q
Sbjct: 121 -----------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ 168
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 35/179 (19%)
Query: 153 AWYHGRIPRQVSENLVQ--RDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSE 210
+WY GR+ RQ + L+Q R G FLVRDS +SPG++VL+ + H+ IN + R
Sbjct: 12 SWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71
Query: 211 AYSRVQ---------YQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRC 261
S Q + + FDS+P L+ Y I + +P++R
Sbjct: 72 PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY-----KIHYLDTTTLIEPVSR------ 120
Query: 262 LEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLP--RGNLLRNKEKSGSQ 318
+R+GS R + A+ + E++LP +G++LR ++K Q
Sbjct: 121 -----------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ 168
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 49.3 bits (116), Expect = 1e-05
Identities = 22/56 (39%), Positives = 35/56 (62%), Gaps = 2/56 (3%)
Query: 149 LRSHAWYHGRIPRQVSENLVQR--DGDFLVRDSLSSPGNFVLTCQWKNLAQHFKIN 202
L H+WYHG + R +E L+ +G FLVR+S SSPG ++ +++ H++IN
Sbjct: 122 LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRIN 177
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,051,640
Number of Sequences: 37866
Number of extensions: 1745194
Number of successful extensions: 6026
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 149
Number of HSP's that attempted gapping in prelim test: 5807
Number of HSP's gapped (non-prelim): 277
length of query: 825
length of database: 18,247,518
effective HSP length: 111
effective length of query: 714
effective length of database: 14,044,392
effective search space: 10027695888
effective search space used: 10027695888
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.