Search of human proteins with 42794771

Search of human proteins with 42794771

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42794771 thioredoxin domain containing 5 isoform 1 precursor
[Homo sapiens]
         (432 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42794771 thioredoxin domain containing 5 isoform 1 precursor ...   903   0.0  
gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo sap...   674   0.0  
gi|5031973 protein disulfide isomerase A6 [Homo sapiens]              145   5e-35
gi|4758304 protein disulfide isomerase A4 [Homo sapiens]              144   1e-34
gi|5803121 protein disulfide isomerase A5 [Homo sapiens]              132   5e-31
gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo s...   120   2e-27
gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]   101   1e-21
gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s...    86   5e-17
gi|38505222 thioredoxin domain containing 10 [Homo sapiens]            82   7e-16
gi|94966757 protein disulfide isomerase A2 [Homo sapiens]              80   5e-15
gi|52487191 thioredoxin domain containing 4 (endoplasmic reticul...    68   2e-11
gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo sap...    64   3e-10
gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo sap...    64   3e-10
gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]           61   2e-09
gi|21361403 thioredoxin 2 precursor [Homo sapiens]                     54   2e-07
gi|28372543 protein disulfide isomerase-like, testis expressed [...    54   2e-07
gi|151101292 thioredoxin domain containing 1 [Homo sapiens]            53   5e-07
gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sa...    53   5e-07
gi|50592994 thioredoxin [Homo sapiens]                                 51   2e-06
gi|4759274 thioredoxin-like 1 [Homo sapiens]                           48   2e-05
gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo sa...    47   4e-05
gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo sa...    47   4e-05
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap...    47   4e-05
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap...    47   4e-05
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi...    47   4e-05
gi|94421469 disulfide isomerase [Homo sapiens]                         45   1e-04
gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo sa...    43   5e-04
gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo sapi...    43   5e-04
gi|95113651 glutaredoxin 3 [Homo sapiens]                              42   0.001
gi|54633317 thioredoxin domain containing 11 [Homo sapiens]            39   0.012

>gi|42794771 thioredoxin domain containing 5 isoform 1 precursor
           [Homo sapiens]
          Length = 432

 Score =  903 bits (2334), Expect = 0.0
 Identities = 432/432 (100%), Positives = 432/432 (100%)

Query: 1   MPARPGRLLPLLARPAALTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAADGEDGQDP 60
           MPARPGRLLPLLARPAALTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAADGEDGQDP
Sbjct: 1   MPARPGRLLPLLARPAALTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAADGEDGQDP 60

Query: 61  HSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVD 120
           HSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVD
Sbjct: 61  HSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVD 120

Query: 121 CTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVE 180
           CTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVE
Sbjct: 121 CTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVE 180

Query: 181 PPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETV 240
           PPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETV
Sbjct: 181 PPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETV 240

Query: 241 KIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETG 300
           KIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETG
Sbjct: 241 KIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETG 300

Query: 301 ATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTW 360
           ATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTW
Sbjct: 301 ATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTW 360

Query: 361 EELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSL 420
           EELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSL
Sbjct: 361 EELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSL 420

Query: 421 HRFVLSQAKDEL 432
           HRFVLSQAKDEL
Sbjct: 421 HRFVLSQAKDEL 432


>gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo
           sapiens]
          Length = 324

 Score =  674 bits (1740), Expect = 0.0
 Identities = 324/324 (100%), Positives = 324/324 (100%)

Query: 109 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL 168
           MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL
Sbjct: 1   MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL 60

Query: 169 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE 228
           NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE
Sbjct: 61  NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE 120

Query: 229 QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE 288
           QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE
Sbjct: 121 QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE 180

Query: 289 YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP 348
           YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP
Sbjct: 181 YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP 240

Query: 349 WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV 408
           WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV
Sbjct: 241 WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV 300

Query: 409 SEHSGGRDLDSLHRFVLSQAKDEL 432
           SEHSGGRDLDSLHRFVLSQAKDEL
Sbjct: 301 SEHSGGRDLDSLHRFVLSQAKDEL 324



 Score =  204 bits (518), Expect = 2e-52
 Identities = 106/235 (45%), Positives = 139/235 (59%), Gaps = 10/235 (4%)

Query: 67  TADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSD 126
           +A  F   +    HF+ FFAPWCGHC+ L PTW  L       E  K  + KVDCT H +
Sbjct: 87  SASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVK--IGKVDCTQHYE 144

Query: 127 VCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNE------EPVTPEPEVE 180
           +CS   VRGYPTL  F+ G++  +Y+G RD ++L  ++   L        E VTP     
Sbjct: 145 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPV 204

Query: 181 PPSAPELKQG-LYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLA-LGLEHSE 238
             + PE  +G +  L+ +NF+  +A+G  FIKF+APWCGHCK LAPTWE+L+        
Sbjct: 205 LAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLA 264

Query: 239 TVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 293
            VKI +VDCT    +CS   VRGYPTLL FR GKKV ++ G RDL+SL  +V SQ
Sbjct: 265 GVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQ 319



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 1/122 (0%)

Query: 50  PAADGEDGQDPHSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSM 109
           P    E   D  +    T + F   I     F+ F+APWCGHC+ L PTW +L  K    
Sbjct: 203 PVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKK-EFP 261

Query: 110 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLN 169
             A V +A+VDCTA  ++CS   VRGYPTL LF+ G++  ++ G RD  +L  ++L    
Sbjct: 262 GLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAK 321

Query: 170 EE 171
           +E
Sbjct: 322 DE 323


>gi|5031973 protein disulfide isomerase A6 [Homo sapiens]
          Length = 440

 Score =  145 bits (367), Expect = 5e-35
 Identities = 81/237 (34%), Positives = 128/237 (54%), Gaps = 23/237 (9%)

Query: 193 ELSASNFELHVAQGDHF--IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQH 250
           EL+ SNF   V Q D    ++F+APWCGHC+ L P W++ A  L+  + VK+G VD  +H
Sbjct: 29  ELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALK--DVVKVGAVDADKH 86

Query: 251 YELCSGNQVRGYPTLLWFRDGK-KVDQYKGKRD--------LESLREYVESQLQRTETGA 301
           + L     V+G+PT+  F   K + + Y+G R         L +LR+ V+ +L     G 
Sbjct: 87  HSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGY 146

Query: 302 TETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGITFIKFYAPWCGHCKTLAPT 359
           +                + K  V+ LT+++FD  +  +E +  ++FYAPWCGHCK L P 
Sbjct: 147 SSGKQ-------GRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPE 199

Query: 360 WEELSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGR 415
           W   + +      G VK+A VD T  + + S+Y +RG+PT+ +F+ G+   ++ GGR
Sbjct: 200 WAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGR 256



 Score =  109 bits (272), Expect = 6e-24
 Identities = 68/213 (31%), Positives = 103/213 (48%), Gaps = 17/213 (7%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V F+APWCGHCQRL P W        +++D  V V  VD   H  +    GV+G+PT+K+
Sbjct: 48  VEFYAPWCGHCQRLTPEWKKAA---TALKDV-VKVGAVDADKHHSLGGQYGVQGFPTIKI 103

Query: 142 FKPGQEAVK-YQGPRDFQTLENWMLQTLNE--------EPVTPEPEVEPPSAPELKQGLY 192
           F   +   + YQG R  + + +  L  L +                 +  S    K+ + 
Sbjct: 104 FGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVI 163

Query: 193 ELSASNFELHVAQGDH--FIKFFAPWCGHCKALAPTWEQLALGLEHSE--TVKIGKVDCT 248
           EL+  +F+ +V   +    ++F+APWCGHCK L P W   A  ++      VK+  VD T
Sbjct: 164 ELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDAT 223

Query: 249 QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKR 281
            +  L S   +RG+PT+  F+ G+    Y G R
Sbjct: 224 VNQVLASRYGIRGFPTIKIFQKGESPVDYDGGR 256



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 34/95 (35%), Positives = 51/95 (53%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V F+APWCGHC+ L+P W     +       KV +A VD T +  + S  G+RG+PT+K+
Sbjct: 183 VEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKI 242

Query: 142 FKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPE 176
           F+ G+  V Y G R    + +  L   ++    PE
Sbjct: 243 FQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPE 277


>gi|4758304 protein disulfide isomerase A4 [Homo sapiens]
          Length = 645

 Score =  144 bits (364), Expect = 1e-34
 Identities = 89/280 (31%), Positives = 145/280 (51%), Gaps = 24/280 (8%)

Query: 152 QGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDH-FI 210
           +GP +  +     ++   EE    + E E     + + G+  L+ +NF+  VA  D   +
Sbjct: 25  EGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLL 84

Query: 211 KFFAPWCGHCKALAPTWEQLALGLEHSET-VKIGKVDCTQHYELCSGNQVRGYPTLLWFR 269
           +F+APWCGHCK  AP +E++A  L+  +  + + K+D T    L S   V GYPT+   +
Sbjct: 85  EFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILK 144

Query: 270 DGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTE 329
            G+ VD Y+G R  E +   V    Q               P     PE      L LT+
Sbjct: 145 KGQAVD-YEGSRTQEEIVAKVREVSQ---------------PDWTPPPEV----TLVLTK 184

Query: 330 NNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 388
            NFD+ + +  I  ++FYAPWCGHCK LAP +E+ +K+       + +A+VD TAE ++ 
Sbjct: 185 ENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLA 244

Query: 389 SKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQA 428
            ++ V GYPTL +FR G+   +++G R+   +  +++ Q+
Sbjct: 245 KRFDVSGYPTLKIFRKGRPY-DYNGPREKYGIVDYMIEQS 283



 Score =  126 bits (316), Expect = 4e-29
 Identities = 78/212 (36%), Positives = 109/212 (51%), Gaps = 17/212 (8%)

Query: 84  FFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFK 143
           F+APWCGHC++  P +  + +     +D  + VAK+D T+ S + S   V GYPT+K+ K
Sbjct: 86  FYAPWCGHCKQFAPEYEKIANILKD-KDPPIPVAKIDATSASVLASRFDVSGYPTIKILK 144

Query: 144 PGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHV 203
            GQ AV Y+G R              EE V    EV  P      +    L+  NF+  V
Sbjct: 145 KGQ-AVDYEGSR------------TQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVV 191

Query: 204 AQGD-HFIKFFAPWCGHCKALAPTWEQLALGL-EHSETVKIGKVDCTQHYELCSGNQVRG 261
              D   ++F+APWCGHCK LAP +E+ A  L + S  + + KVD T   +L     V G
Sbjct: 192 NDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSG 251

Query: 262 YPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 293
           YPTL  FR G+  D Y G R+   + +Y+  Q
Sbjct: 252 YPTLKIFRKGRPYD-YNGPREKYGIVDYMIEQ 282



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 61/173 (35%), Positives = 89/173 (51%), Gaps = 21/173 (12%)

Query: 271 GKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTEN 330
           GKK      + D ++LRE+V +     + G  + V  S+ PV    P+ +KG V  +   
Sbjct: 483 GKKFAMEPEEFDSDTLREFVTA----FKKGKLKPVIKSQ-PV----PKNNKGPVKVVVGK 533

Query: 331 NFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 388
            FD  + +      I+FYAPWCGHCK L P +  L+KK + G  G+ IA++D TA     
Sbjct: 534 TFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKK-YKGQKGLVIAKMDATANDVPS 592

Query: 389 SKYSVRGYPTLLLFRGGKK---VSEHSGGRDLDSLHRFV------LSQAKDEL 432
            +Y V G+PT+     G K   V    G RDL+ L +F+      LS+ K+EL
Sbjct: 593 DRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL 645



 Score = 69.7 bits (169), Expect = 5e-12
 Identities = 34/85 (40%), Positives = 51/85 (60%), Gaps = 2/85 (2%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V F+APWCGHC++L P +     K  S     + +AKVD TA +D+     V GYPTLK+
Sbjct: 199 VEFYAPWCGHCKKLAPEYEKAA-KELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKI 257

Query: 142 FKPGQEAVKYQGPRDFQTLENWMLQ 166
           F+ G+    Y GPR+   + ++M++
Sbjct: 258 FRKGR-PYDYNGPREKYGIVDYMIE 281



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 36/98 (36%), Positives = 55/98 (56%), Gaps = 6/98 (6%)

Query: 207 DHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLL 266
           D  I+F+APWCGHCK L P +  LA   +  + + I K+D T +       +V G+PT+ 
Sbjct: 545 DVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIY 604

Query: 267 WFRDGKKVDQYK---GKRDLESLREYVE---SQLQRTE 298
           +   G K +  K   G RDLE L +++E   ++L RT+
Sbjct: 605 FAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTK 642



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 30/86 (34%), Positives = 49/86 (56%), Gaps = 5/86 (5%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           + F+APWCGHC++L+P +N L  KY   +   + +AK+D TA+        V G+PT+  
Sbjct: 548 IEFYAPWCGHCKQLEPVYNSLAKKYKGQKG--LVIAKMDATANDVPSDRYKVEGFPTIYF 605

Query: 142 FKPG--QEAVKYQ-GPRDFQTLENWM 164
              G  +  VK++ G RD + L  ++
Sbjct: 606 APSGDKKNPVKFEGGDRDLEHLSKFI 631


>gi|5803121 protein disulfide isomerase A5 [Homo sapiens]
          Length = 519

 Score =  132 bits (333), Expect = 5e-31
 Identities = 109/385 (28%), Positives = 175/385 (45%), Gaps = 49/385 (12%)

Query: 48  GPPAADGEDGQDPHSK---HLYTADMFTHGIQSAAH--FVMFFAPWCGHCQRLQPTWNDL 102
           GPP  +    +DP +K   HL +   F   ++       +MF+APWC  C+R+ P +   
Sbjct: 140 GPPLWE----EDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKA 195

Query: 103 GDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQG-PRDFQTLE 161
             +      A +    V  +   ++     VRG+PT+  F+ G+   +Y       + + 
Sbjct: 196 ATQLRG--HAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIV 253

Query: 162 NWMLQTLNEEPVTPEPEVEPPSAPELKQG--LYELSASNFELHVAQGDH-FIKFFAPWCG 218
            W+     + P  P+P+V  P  P   +G  +Y L+  +F+  V +     + F APWCG
Sbjct: 254 EWL-----KNPQPPQPQV--PETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCG 306

Query: 219 HCKALAPTWEQLALGLEHSETVKIG---KVDCTQHYELCSGNQVRGYPTLLWFRDGKKVD 275
           HCK + P +E+ A  L H E    G    VD T +  L     +  +PTL +F++G+K  
Sbjct: 307 HCKKMKPEFEKAAEAL-HGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEK-- 363

Query: 276 QYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEP--EADKGTVLALTENNFD 333
                        Y    L RT+    E +   EAP    EP  E  + +VL L  +NF 
Sbjct: 364 -------------YAVPVL-RTKKKFLEWMQNPEAPP-PPEPTWEEQQTSVLHLVGDNFR 408

Query: 334 DTIAEGI-TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN--ICSK 390
           +T+ +   T + FYAPWC HCK + P +   +   F     +  A VDC  ++N  +C +
Sbjct: 409 ETLKKKKHTLVMFYAPWCPHCKKVIPHF-TATADAFKDDRKIACAAVDCVKDKNQDLCQQ 467

Query: 391 YSVRGYPTLLLFRGGKKVSEHSGGR 415
            +V+GYPT   +  GK   ++   R
Sbjct: 468 EAVKGYPTFHYYHYGKFAEKYDSDR 492



 Score =  110 bits (276), Expect = 2e-24
 Identities = 68/234 (29%), Positives = 106/234 (45%), Gaps = 15/234 (6%)

Query: 64  HLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTA 123
           HL   D      + ++  VMF APWCGHC++++P +    +  +   D+   +A VD T 
Sbjct: 280 HLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATV 339

Query: 124 HSDVCSAQGVRGYPTLKLFKPGQEAVKYQGP--RDFQTLENWMLQTLNEEPVTPEPEVEP 181
           +  +     +  +PTLK FK G+   KY  P  R  +    WM     E P  PEP  E 
Sbjct: 340 NKALAERFHISEFPTLKYFKNGE---KYAVPVLRTKKKFLEWMQNP--EAPPPPEPTWE- 393

Query: 182 PSAPELKQGLYELSASNFELHVAQGDH-FIKFFAPWCGHCKALAPTWEQLALGLEHSETV 240
               E +  +  L   NF   + +  H  + F+APWC HCK + P +   A   +    +
Sbjct: 394 ----EQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKI 449

Query: 241 KIGKVDCT--QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVES 292
               VDC   ++ +LC    V+GYPT  ++  GK  ++Y   R       Y+ +
Sbjct: 450 ACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRA 503


>gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo
           sapiens]
          Length = 793

 Score =  120 bits (302), Expect = 2e-27
 Identities = 86/333 (25%), Positives = 140/333 (42%), Gaps = 68/333 (20%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V FFAPWC  C+ L P       + +++   ++    +DCT H  +C+   ++ YPT  +
Sbjct: 473 VDFFAPWCPPCRALLPELR----RASNLLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVV 528

Query: 142 FKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFEL 201
           F       +Y+G    + +  ++   +N   V+                   L+ + F  
Sbjct: 529 FNQ-SNIHEYEGHHSAEQILEFIEDLMNPSVVS-------------------LTPTTFNE 568

Query: 202 HVAQGDH----FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGN 257
            V Q  H     + F++PWC  C+ L P W+++A  L  +  + +G +DC Q++  C+  
Sbjct: 569 LVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTL--TGLINVGSIDCQQYHSFCAQE 626

Query: 258 QVRGYPTLLWF----RDGKKVDQYKG-KRDLESLREYVESQLQRTETGATETVTPSEAPV 312
            V+ YP + +F            Y G  RD  SLR +    L +  T             
Sbjct: 627 NVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFLPQVSTD------------ 674

Query: 313 LAAEPEADKGTVLALTENNFDDTIAEGIT--FIKFYAPWCGHCKTLAPTWEELSKKEFPG 370
                         LT   F + + +G     I FYAPWCG C+  AP +E L++     
Sbjct: 675 --------------LTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARM---- 716

Query: 371 LAG-VKIAEVDCTAERNICSKYSVRGYPTLLLF 402
           + G VK  +VDC A    C K  +R YPT+  +
Sbjct: 717 IKGKVKAGKVDCQAYAQTCQKAGIRAYPTVKFY 749



 Score =  101 bits (251), Expect = 2e-21
 Identities = 76/313 (24%), Positives = 139/313 (44%), Gaps = 63/313 (20%)

Query: 109 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQ---GPRDFQTLENWML 165
           +++  + V + DC++  D+CS   V   P+L +FK GQ   +Y+   G +    +  +  
Sbjct: 391 LKNDHIQVGRFDCSSAPDICSNLYVF-QPSLAVFK-GQGTKEYEIHHGKKILYDILAFAK 448

Query: 166 QTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAP 225
           +++N    T  P+  P +  E                       + FFAPWC  C+AL P
Sbjct: 449 ESVNSHVTTLGPQNFPANDKE--------------------PWLVDFFAPWCPPCRALLP 488

Query: 226 TWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLES 285
              + A  L + + +K G +DCT H  LC+   ++ YPT + F     + +Y+G    E 
Sbjct: 489 ELRR-ASNLLYGQ-LKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSN-IHEYEGHHSAEQ 545

Query: 286 LREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG----IT 341
           + E++E           + + PS               V++LT   F++ + +     + 
Sbjct: 546 ILEFIE-----------DLMNPS---------------VVSLTPTTFNELVTQRKHNEVW 579

Query: 342 FIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLL 401
            + FY+PWC  C+ L P W+ ++ +   GL  + +  +DC    + C++ +V+ YP +  
Sbjct: 580 MVDFYSPWCHPCQVLMPEWKRMA-RTLTGL--INVGSIDCQQYHSFCAQENVQRYPEIRF 636

Query: 402 F--RGGKKVSEHS 412
           F  +  K    HS
Sbjct: 637 FPPKSNKAYHYHS 649



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 60/207 (28%), Positives = 90/207 (43%), Gaps = 32/207 (15%)

Query: 69  DMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVC 128
           ++ T    +    V F++PWC  CQ L P W  +      +    + V  +DC  +   C
Sbjct: 568 ELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGL----INVGSIDCQQYHSFC 623

Query: 129 SAQGVRGYPTLKLFKPGQEAV----KYQG-PRDFQTLENWMLQTLNEEPVTPEPEVEPPS 183
           + + V+ YP ++ F P          Y G  RD  +L  W L  L        P+V    
Sbjct: 624 AQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFL--------PQVSTDL 675

Query: 184 APELKQGLYELSASNFELHVAQGDHF--IKFFAPWCGHCKALAPTWEQLALGLEHSETVK 241
            P+            F   V QG +   I F+APWCG C+  AP +E LA  ++    VK
Sbjct: 676 TPQ-----------TFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGK--VK 722

Query: 242 IGKVDCTQHYELCSGNQVRGYPTLLWF 268
            GKVDC  + + C    +R YPT+ ++
Sbjct: 723 AGKVDCQAYAQTCQKAGIRAYPTVKFY 749



 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 38/111 (34%), Positives = 58/111 (52%), Gaps = 4/111 (3%)

Query: 320 DKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAE 378
           D   ++ L    FD  +  G + F+ FY+P C HC  LAPTW + + KE  GL  ++I  
Sbjct: 127 DDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFA-KEVDGL--LRIGA 183

Query: 379 VDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAK 429
           V+C  +R +C    V  YP+L +FR G    ++ G R  +SL  F +   +
Sbjct: 184 VNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQHVR 234



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 58/201 (28%), Positives = 81/201 (40%), Gaps = 29/201 (14%)

Query: 194 LSASNFELHVAQGD-HFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 252
           L    F+  V  G+  F+ F++P C HC  LAPTW   A   E    ++IG V+C     
Sbjct: 134 LERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAK--EVDGLLRIGAVNCGDDRM 191

Query: 253 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPV 312
           LC    V  YP+L  FR G    +Y G R  ESL   V   +Q   +  TE  T +    
Sbjct: 192 LCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESL---VSFAMQHVRSTVTELWTGNFV-- 246

Query: 313 LAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLA 372
                            N+     A GI ++  +    G C T + T   LS     GL 
Sbjct: 247 -----------------NSIQTAFAAGIGWLITFCSKGGDCLT-SQTRLRLSGM-LDGL- 286

Query: 373 GVKIAEVDCTAERNICSKYSV 393
            V +  +DC  + N+C    +
Sbjct: 287 -VNVGWMDCATQDNLCKSLDI 306



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 46/174 (26%), Positives = 74/174 (42%), Gaps = 22/174 (12%)

Query: 81  FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLK 140
           FV F++P C HC  L PTW D   +     D  + +  V+C     +C  +GV  YP+L 
Sbjct: 150 FVNFYSPGCSHCHDLAPTWRDFAKEV----DGLLRIGAVNCGDDRMLCRMKGVNSYPSLF 205

Query: 141 LFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFE 200
           +F+ G   VKY G R  ++L ++ +Q +              +  EL  G +    ++ +
Sbjct: 206 IFRSGMAPVKYHGDRSKESLVSFAMQHVRS------------TVTELWTGNF---VNSIQ 250

Query: 201 LHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELC 254
              A G  ++  F    G C     +  +L L       V +G +DC     LC
Sbjct: 251 TAFAAGIGWLITFCSKGGDC---LTSQTRLRLSGMLDGLVNVGWMDCATQDNLC 301


>gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens]
          Length = 505

 Score =  101 bits (252), Expect = 1e-21
 Identities = 55/127 (43%), Positives = 76/127 (59%), Gaps = 9/127 (7%)

Query: 307 PSEAPVLAAEPEADKGTVLALTENNFD----DTIAEGITFIKFYAPWCGHCKTLAPTWEE 362
           P  A +LAA   A    VL LT++NF+    DT + G+  ++F+APWCGHCK LAP +E 
Sbjct: 10  PGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69

Query: 363 LSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLH 421
            + +    L G V +A+VDCTA  N C+KY V GYPTL +FR G++   + G R  D + 
Sbjct: 70  AATR----LKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIV 125

Query: 422 RFVLSQA 428
             +  QA
Sbjct: 126 SHLKKQA 132



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 38/74 (51%), Positives = 50/74 (67%), Gaps = 4/74 (5%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V FFAPWCGHC+RL P +     +   +    V +AKVDCTA+++ C+  GV GYPTLK+
Sbjct: 50  VEFFAPWCGHCKRLAPEYEAAATRLKGI----VPLAKVDCTANTNTCNKYGVSGYPTLKI 105

Query: 142 FKPGQEAVKYQGPR 155
           F+ G+EA  Y GPR
Sbjct: 106 FRDGEEAGAYDGPR 119



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 43/105 (40%), Positives = 60/105 (57%), Gaps = 6/105 (5%)

Query: 193 ELSASNFELHVAQ----GDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCT 248
           EL+  NFE  ++     G   ++FFAPWCGHCK LAP +E  A  L+    V + KVDCT
Sbjct: 29  ELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAKVDCT 86

Query: 249 QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 293
            +   C+   V GYPTL  FRDG++   Y G R  + +  +++ Q
Sbjct: 87  ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQ 131



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 53/164 (32%), Positives = 86/164 (52%), Gaps = 27/164 (16%)

Query: 269 RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALT 328
           RDGK ++++        L++Y +  L+R           SE P+    PE++ G V  + 
Sbjct: 344 RDGKALERF--------LQDYFDGNLKR--------YLKSE-PI----PESNDGPVKVVV 382

Query: 329 ENNFDDTI--AEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 386
             NFD+ +        I+FYAPWCGHCK L P ++EL +K       + IA++D TA  +
Sbjct: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEK-LSKDPNIVIAKMDATA-ND 440

Query: 387 ICSKYSVRGYPTLLLFRGGKKVS--EHSGGRDLDSLHRFVLSQA 428
           + S Y VRG+PT+      KK++  ++ GGR+L     ++  +A
Sbjct: 441 VPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREA 484



 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 36/98 (36%), Positives = 59/98 (60%), Gaps = 7/98 (7%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           + F+APWCGHC+ L+P + +LG+K +  +D  + +AK+D TA +DV S   VRG+PT+  
Sbjct: 399 IEFYAPWCGHCKNLEPKYKELGEKLS--KDPNIVIAKMDATA-NDVPSPYEVRGFPTI-Y 454

Query: 142 FKPGQEAV---KYQGPRDFQTLENWMLQTLNEEPVTPE 176
           F P  + +   KY+G R+     +++ +     PV  E
Sbjct: 455 FSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQE 492



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 35/102 (34%), Positives = 60/102 (58%), Gaps = 5/102 (4%)

Query: 196 ASNFE--LHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYEL 253
           A NF+  ++    D  I+F+APWCGHCK L P +++L   L     + I K+D T + ++
Sbjct: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN-DV 441

Query: 254 CSGNQVRGYPTLLWFRDGKKVD--QYKGKRDLESLREYVESQ 293
            S  +VRG+PT+ +    KK++  +Y+G R+L     Y++ +
Sbjct: 442 PSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQRE 483


>gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo
           sapiens]
          Length = 508

 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 42/114 (36%), Positives = 69/114 (60%), Gaps = 3/114 (2%)

Query: 310 APVLAAEPEADKGTVLALTENNFDDTIA-EGITFIKFYAPWCGHCKTLAPTWEELSKKEF 368
           A ++ A+   ++  VL L ++NF + +A      ++FYAPWCGHCK LAP + + + K  
Sbjct: 12  AALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLK 71

Query: 369 PGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVS--EHSGGRDLDSL 420
              + +++A+VD T E ++  +Y VRGYPT+  FR G   S  E++ GR+ D +
Sbjct: 72  AEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDI 125



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 51/149 (34%), Positives = 78/149 (52%), Gaps = 14/149 (9%)

Query: 184 APELKQGLYELSASNFELHVAQGDHF-IKFFAPWCGHCKALAPTWEQLA--LGLEHSETV 240
           APE +  +  L  SNF   +A   +  ++F+APWCGHCKALAP + + A  L  E SE +
Sbjct: 19  APEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSE-I 77

Query: 241 KIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVD--QYKGKRDLESLREYVESQLQRTE 298
           ++ KVD T+  +L     VRGYPT+ +FR+G      +Y   R+ + +  +++ +     
Sbjct: 78  RLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKR----- 132

Query: 299 TGATETVTPSEAPVLAAEPEADKGTVLAL 327
           TG   T  P  A   AAE   +   V  +
Sbjct: 133 TGPAATTLPDGA---AAESLVESSEVAVI 158



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 38/92 (41%), Positives = 53/92 (57%), Gaps = 6/92 (6%)

Query: 78  AAH---FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVR 134
           AAH    V F+APWCGHC+ L P +     K  + E +++ +AKVD T  SD+    GVR
Sbjct: 39  AAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKA-EGSEIRLAKVDATEESDLAQQYGVR 97

Query: 135 GYPTLKLFKPGQEA--VKYQGPRDFQTLENWM 164
           GYPT+K F+ G  A   +Y   R+   + NW+
Sbjct: 98  GYPTIKFFRNGDTASPKEYTAGREADDIVNWL 129



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 42/115 (36%), Positives = 61/115 (53%), Gaps = 7/115 (6%)

Query: 320 DKGTVLALTENNFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIA 377
           DK  V  L   NF+D   +     F++FYAPWCGHCK LAP W++L  + +     + IA
Sbjct: 365 DKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLG-ETYKDHENIVIA 423

Query: 378 EVDCTAERNICSKYSVRGYPTLLLF--RGGKKVSEHSGGRDLDSLHRFVLSQAKD 430
           ++D TA  N      V  +PTL  F     + V +++G R LD   +F+ S  +D
Sbjct: 424 KMDSTA--NEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQD 476



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 40/110 (36%), Positives = 61/110 (55%), Gaps = 8/110 (7%)

Query: 188 KQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGK 244
           KQ +  L   NFE  VA  +    F++F+APWCGHCK LAP W++L    +  E + I K
Sbjct: 366 KQPVKVLVGKNFE-DVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAK 424

Query: 245 VDCTQHYELCSGNQVRGYPTLLWF--RDGKKVDQYKGKRDLESLREYVES 292
           +D T +       +V  +PTL +F     + V  Y G+R L+  ++++ES
Sbjct: 425 MDSTANE--VEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLES 472



 Score = 65.5 bits (158), Expect = 9e-11
 Identities = 32/86 (37%), Positives = 48/86 (55%), Gaps = 6/86 (6%)

Query: 81  FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLK 140
           FV F+APWCGHC++L P W+ LG+ Y   E+  + +AK+D TA+     A  V  +PTLK
Sbjct: 389 FVEFYAPWCGHCKQLAPIWDKLGETYKDHEN--IVIAKMDSTANE--VEAVKVHSFPTLK 444

Query: 141 LFKPGQE--AVKYQGPRDFQTLENWM 164
            F    +   + Y G R     + ++
Sbjct: 445 FFPASADRTVIDYNGERTLDGFKKFL 470


>gi|38505222 thioredoxin domain containing 10 [Homo sapiens]
          Length = 454

 Score = 82.4 bits (202), Expect = 7e-16
 Identities = 38/74 (51%), Positives = 53/74 (71%), Gaps = 2/74 (2%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V F+APWCGHC++L+P WN++G +  S+  + V V K+D T++S + S  GVRGYPT+KL
Sbjct: 46  VDFYAPWCGHCKKLEPIWNEVGLEMKSI-GSPVKVGKMDATSYSSIASEFGVRGYPTIKL 104

Query: 142 FKPGQEAVKYQGPR 155
            K G  A  Y+GPR
Sbjct: 105 LK-GDLAYNYRGPR 117



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 41/114 (35%), Positives = 62/114 (54%), Gaps = 2/114 (1%)

Query: 310 APVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFP 369
           A V+  +    KG V  L E+ F +   + I  + FYAPWCGHCK L P W E+  +   
Sbjct: 14  ATVVVLDMVVCKGFVEDLDES-FKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKS 72

Query: 370 GLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRF 423
             + VK+ ++D T+  +I S++ VRGYPT+ L +G    + + G R  D +  F
Sbjct: 73  IGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYN-YRGPRTKDDIIEF 125



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 31/81 (38%), Positives = 47/81 (58%), Gaps = 2/81 (2%)

Query: 210 IKFFAPWCGHCKALAPTWEQLALGLEH-SETVKIGKVDCTQHYELCSGNQVRGYPTLLWF 268
           + F+APWCGHCK L P W ++ L ++     VK+GK+D T +  + S   VRGYPT+   
Sbjct: 46  VDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLL 105

Query: 269 RDGKKVDQYKGKRDLESLREY 289
           + G     Y+G R  + + E+
Sbjct: 106 K-GDLAYNYRGPRTKDDIIEF 125


>gi|94966757 protein disulfide isomerase A2 [Homo sapiens]
          Length = 525

 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 44/112 (39%), Positives = 64/112 (57%), Gaps = 7/112 (6%)

Query: 317 PEADKGTVLALTENNFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGV 374
           P+ D+  V  L   NF+    +     F+KFYAPWC HCK +AP WE L++K +     +
Sbjct: 383 PDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEK-YQDHEDI 441

Query: 375 KIAEVDCTAERNICSKYSVRGYPTLLLFRG--GKKVSEHSGGRDLDSLHRFV 424
            IAE+D TA  N    ++V G+PTL  F    G+KV E+   RDL++  +F+
Sbjct: 442 IIAELDATA--NELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFL 491



 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 42/112 (37%), Positives = 62/112 (55%), Gaps = 15/112 (13%)

Query: 81  FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLK 140
           FV F+APWC HC+ + P W  L +KY   ED  + +A++D TA+     A  V G+PTLK
Sbjct: 410 FVKFYAPWCTHCKEMAPAWEALAEKYQDHED--IIIAELDATANE--LDAFAVHGFPTLK 465

Query: 141 LFK--PGQEAVKYQGPRDFQTLENWM-------LQTLNEEPVTPEPEVEPPS 183
            F   PG++ ++Y+  RD +T   ++        +   EEP  P P  EPP+
Sbjct: 466 YFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAAPFP--EPPA 515



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 46/123 (37%), Positives = 66/123 (53%), Gaps = 11/123 (8%)

Query: 209 FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWF 268
           F+KF+APWC HCK +AP WE LA   +  E + I ++D T + EL     V G+PTL +F
Sbjct: 410 FVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATAN-EL-DAFAVHGFPTLKYF 467

Query: 269 --RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLA 326
               G+KV +YK  RDLE+  +++++       G   T  P E P  A  PE    + + 
Sbjct: 468 PAGPGRKVIEYKSTRDLETFSKFLDN------GGVLPTEEPPEEPA-APFPEPPANSTMG 520

Query: 327 LTE 329
             E
Sbjct: 521 SKE 523



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 55/165 (33%), Positives = 78/165 (47%), Gaps = 13/165 (7%)

Query: 18  LTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAAD--GEDGQDPHSKHLYTADMFTHGI 75
           L  LLLLLL       WG   ++ A + ++ PP  +   EDG    S+H     +  H  
Sbjct: 6   LPVLLLLLLR--ASCPWGQ--EQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREH-- 59

Query: 76  QSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRG 135
              A  V F+APWCGHCQ L P ++       + E   V +AKVD  A  ++    GV  
Sbjct: 60  --PALLVEFYAPWCGHCQALAPEYSKAA-AVLAAESMVVTLAKVDGPAQRELAEEFGVTE 116

Query: 136 YPTLKLFKPGQEA--VKYQGPRDFQTLENWMLQTLNEEPVTPEPE 178
           YPTLK F+ G      +Y GPRD + +  W+ + +    +  E E
Sbjct: 117 YPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDE 161



 Score = 72.4 bits (176), Expect = 7e-13
 Identities = 57/182 (31%), Positives = 86/182 (47%), Gaps = 18/182 (9%)

Query: 170 EEPVTPEPEVEPPSAPELKQ-GLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAP 225
           +E     P  EPP     K+ G+  LS     L +A  +H    ++F+APWCGHC+ALAP
Sbjct: 22  QEQGARSPSEEPPEEEIPKEDGILVLSRHT--LGLALREHPALLVEFYAPWCGHCQALAP 79

Query: 226 TWEQLALGL-EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKV--DQYKGKRD 282
            + + A  L   S  V + KVD     EL     V  YPTL +FR+G +   ++Y G RD
Sbjct: 80  EYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRD 139

Query: 283 LESLREYVE-----SQLQRTETGATETVTPSEAPVLAA----EPEADKGTVLALTENNFD 333
            E + E++      S ++  +  A + +      V+        + D  T LAL ++  D
Sbjct: 140 AEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALD 199

Query: 334 DT 335
            T
Sbjct: 200 MT 201



 Score = 69.3 bits (168), Expect = 6e-12
 Identities = 39/118 (33%), Positives = 62/118 (52%), Gaps = 5/118 (4%)

Query: 306 TPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELS 364
           +PSE P     P+ D   +L L+ +     + E     ++FYAPWCGHC+ LAP + + +
Sbjct: 28  SPSEEPPEEEIPKEDG--ILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAA 85

Query: 365 KKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV--SEHSGGRDLDSL 420
                    V +A+VD  A+R +  ++ V  YPTL  FR G +    E++G RD + +
Sbjct: 86  AVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGI 143


>gi|52487191 thioredoxin domain containing 4 (endoplasmic reticulum)
           [Homo sapiens]
          Length = 406

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 38/114 (33%), Positives = 57/114 (50%), Gaps = 5/114 (4%)

Query: 324 VLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELS---KKEFPGLAGVKIAEV 379
           + +L   N D+ +    +  + FYA WC   + L P +EE S   K+EFP    V  A V
Sbjct: 31  ITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARV 90

Query: 380 DCTAERNICSKYSVRGYPTLLLFRGGKKVS-EHSGGRDLDSLHRFVLSQAKDEL 432
           DC    +I  +Y +  YPTL LFR G  +  E+ G R + +L  ++  Q  D +
Sbjct: 91  DCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPI 144



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 3/88 (3%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGD--KYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTL 139
           V F+A WC   Q L P + +  D  K     + +V  A+VDC  HSD+     +  YPTL
Sbjct: 51  VNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTL 110

Query: 140 KLFKPGQEAVK-YQGPRDFQTLENWMLQ 166
           KLF+ G    + Y+G R  + L +++ Q
Sbjct: 111 KLFRNGMMMKREYRGQRSVKALADYIRQ 138



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 26/89 (29%), Positives = 50/89 (56%), Gaps = 5/89 (5%)

Query: 210 IKFFAPWCGHCKALAPTWEQLALGLE----HSETVKIGKVDCTQHYELCSGNQVRGYPTL 265
           + F+A WC   + L P +E+ +  ++    +   V   +VDC QH ++    ++  YPTL
Sbjct: 51  VNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTL 110

Query: 266 LWFRDGKKVD-QYKGKRDLESLREYVESQ 293
             FR+G  +  +Y+G+R +++L +Y+  Q
Sbjct: 111 KLFRNGMMMKREYRGQRSVKALADYIRQQ 139


>gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo
           sapiens]
          Length = 604

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 69/252 (27%), Positives = 96/252 (38%), Gaps = 38/252 (15%)

Query: 78  AAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCT--AHSDVCSAQGVRG 135
           +A  V FFA WCGHC    PTW  L +   +   A +Y+A +DC    +S VC    + G
Sbjct: 59  SAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPA-LYLAALDCAEETNSAVCRDFNIPG 117

Query: 136 YPTLKLFKP----GQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGL 191
           +PT++ FK     G  AV      D QTL   ++  L     T  P   PP  P   + +
Sbjct: 118 FPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPAC-PPLEPAKLEEI 176

Query: 192 YELSASNFELHVA-----QGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVD 246
               A N E ++A      G +  +  A      K +A    +  L  E +   K G  D
Sbjct: 177 DGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVA---VRRVLNTEANVVRKFGVTD 233

Query: 247 CTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQR----TETGAT 302
               Y L     V   P L+                    R +  + LQR    T   A 
Sbjct: 234 FPSCYLLFRNGSVSRVPVLM------------------ESRSFYTAYLQRLSGLTREAAQ 275

Query: 303 ETVTPSEAPVLA 314
            TV P+ A  +A
Sbjct: 276 TTVAPTTANKIA 287



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 2/67 (2%)

Query: 343 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN--ICSKYSVRGYPTLL 400
           ++F+A WCGHC   APTW+ L++        + +A +DC  E N  +C  +++ G+PT+ 
Sbjct: 63  VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122

Query: 401 LFRGGKK 407
            F+   K
Sbjct: 123 FFKAFTK 129



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 53/204 (25%), Positives = 91/204 (44%), Gaps = 30/204 (14%)

Query: 210 IKFFAPWCGHCKALAPTWEQLALGLE-HSETVKIGKVDCTQ--HYELCSGNQVRGYPTLL 266
           ++FFA WCGHC A APTW+ LA  ++     + +  +DC +  +  +C    + G+PT+ 
Sbjct: 63  VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122

Query: 267 WF----RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKG 322
           +F    ++G          D+++LRE +   L+       +T  P+  P+  A+ E   G
Sbjct: 123 FFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHH----DTWPPACPPLEPAKLEEIDG 178

Query: 323 TVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCT 382
                 E        +G +++       G    L     +LS+ +     GV +  V   
Sbjct: 179 FFARNNEEYLALIFEKGGSYL-------GREVAL-----DLSQHK-----GVAVRRV-LN 220

Query: 383 AERNICSKYSVRGYPT-LLLFRGG 405
            E N+  K+ V  +P+  LLFR G
Sbjct: 221 TEANVVRKFGVTDFPSCYLLFRNG 244


>gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo
           sapiens]
          Length = 747

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 69/252 (27%), Positives = 96/252 (38%), Gaps = 38/252 (15%)

Query: 78  AAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCT--AHSDVCSAQGVRG 135
           +A  V FFA WCGHC    PTW  L +   +   A +Y+A +DC    +S VC    + G
Sbjct: 59  SAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPA-LYLAALDCAEETNSAVCRDFNIPG 117

Query: 136 YPTLKLFKP----GQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGL 191
           +PT++ FK     G  AV      D QTL   ++  L     T  P   PP  P   + +
Sbjct: 118 FPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPAC-PPLEPAKLEEI 176

Query: 192 YELSASNFELHVA-----QGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVD 246
               A N E ++A      G +  +  A      K +A    +  L  E +   K G  D
Sbjct: 177 DGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVA---VRRVLNTEANVVRKFGVTD 233

Query: 247 CTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQR----TETGAT 302
               Y L     V   P L+                    R +  + LQR    T   A 
Sbjct: 234 FPSCYLLFRNGSVSRVPVLM------------------ESRSFYTAYLQRLSGLTREAAQ 275

Query: 303 ETVTPSEAPVLA 314
            TV P+ A  +A
Sbjct: 276 TTVAPTTANKIA 287



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 2/67 (2%)

Query: 343 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN--ICSKYSVRGYPTLL 400
           ++F+A WCGHC   APTW+ L++        + +A +DC  E N  +C  +++ G+PT+ 
Sbjct: 63  VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122

Query: 401 LFRGGKK 407
            F+   K
Sbjct: 123 FFKAFTK 129



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 53/204 (25%), Positives = 91/204 (44%), Gaps = 30/204 (14%)

Query: 210 IKFFAPWCGHCKALAPTWEQLALGLE-HSETVKIGKVDCTQ--HYELCSGNQVRGYPTLL 266
           ++FFA WCGHC A APTW+ LA  ++     + +  +DC +  +  +C    + G+PT+ 
Sbjct: 63  VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122

Query: 267 WF----RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKG 322
           +F    ++G          D+++LRE +   L+       +T  P+  P+  A+ E   G
Sbjct: 123 FFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHH----DTWPPACPPLEPAKLEEIDG 178

Query: 323 TVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCT 382
                 E        +G +++       G    L     +LS+ +     GV +  V   
Sbjct: 179 FFARNNEEYLALIFEKGGSYL-------GREVAL-----DLSQHK-----GVAVRRV-LN 220

Query: 383 AERNICSKYSVRGYPT-LLLFRGG 405
            E N+  K+ V  +P+  LLFR G
Sbjct: 221 TEANVVRKFGVTDFPSCYLLFRNG 244


>gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens]
          Length = 698

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 29/90 (32%), Positives = 44/90 (48%), Gaps = 8/90 (8%)

Query: 320 DKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEV 379
           D G+V   T N+           ++FY+ WCGHC   APTW  L+       + +++A +
Sbjct: 67  DSGSVRGATANS------SAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAAL 120

Query: 380 DCTAERN--ICSKYSVRGYPTLLLFRGGKK 407
           DC  E+N  +C  Y +  YPT   F+   K
Sbjct: 121 DCMEEKNQAVCHDYDIHFYPTFRYFKAFTK 150



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/136 (25%), Positives = 66/136 (48%), Gaps = 15/136 (11%)

Query: 210 IKFFAPWCGHCKALAPTWEQLALGL-EHSETVKIGKVDCTQ--HYELCSGNQVRGYPTLL 266
           ++F++ WCGHC   APTW  LA  + + +  +++  +DC +  +  +C    +  YPT  
Sbjct: 84  VQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFR 143

Query: 267 WFRDGKKV----DQYKG-KRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADK 321
           +F+   K     + +KG  R+L ++R+ +   LQ    G+     P   P+  ++     
Sbjct: 144 YFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSD----- 198

Query: 322 GTVLALTENNFDDTIA 337
             VL+L +N     +A
Sbjct: 199 --VLSLLDNRGSHYVA 212



 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 50/162 (30%), Positives = 66/162 (40%), Gaps = 28/162 (17%)

Query: 43  AAAADGPPAAD-------GEDGQ---DPHSKHLYTADMFTHGIQSAAHFVMFFAPWCGHC 92
           AAAA GP A         GED     D  S    TA+       SAA  V F++ WCGHC
Sbjct: 41  AAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATAN------SSAAWLVQFYSSWCGHC 94

Query: 93  QRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSD--VCSAQGVRGYPTLKLFKPGQE--- 147
               PTW  L         A + VA +DC    +  VC    +  YPT + FK   +   
Sbjct: 95  IGYAPTWRALAGDVRDWASA-IRVAALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFT 153

Query: 148 -AVKYQGP-RDFQTLENWMLQTLNEEPVTPEPEVEPPSAPEL 187
               ++GP R+ +T+   M+  L            PP+ P L
Sbjct: 154 TGENFKGPDRELRTVRQTMIDFLQNH----TEGSRPPACPRL 191


>gi|21361403 thioredoxin 2 precursor [Homo sapiens]
          Length = 166

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 39/129 (30%), Positives = 59/129 (45%), Gaps = 18/129 (13%)

Query: 304 TVTPSEAPVLAAEPEADKGTVLALTENN------FDDTIAEGIT--FIKFYAPWCGHCKT 355
           TVTP+ A  +         T ++LT  N      F D +    T   + F+A WCG CK 
Sbjct: 43  TVTPNPARTIYT-------TRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKI 95

Query: 356 LAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGR 415
           L P  E++  K+      V +A+VD     ++  +Y V   PT+L  + G  V +  G +
Sbjct: 96  LGPRLEKMVAKQH---GKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK 152

Query: 416 DLDSLHRFV 424
           D D L  F+
Sbjct: 153 DEDQLEAFL 161



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 27/82 (32%), Positives = 46/82 (56%), Gaps = 2/82 (2%)

Query: 210 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFR 269
           + F A WCG CK L P  E++ +  +H + V + KVD   H +L    +V   PT+L  +
Sbjct: 83  VDFHAQWCGPCKILGPRLEKM-VAKQHGKVV-MAKVDIDDHTDLAIEYEVSAVPTVLAMK 140

Query: 270 DGKKVDQYKGKRDLESLREYVE 291
           +G  VD++ G +D + L  +++
Sbjct: 141 NGDVVDKFVGIKDEDQLEAFLK 162



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 4/83 (4%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V F A WCG C+ L P      +K  + +  KV +AKVD   H+D+     V   PT+  
Sbjct: 83  VDFHAQWCGPCKILGPRL----EKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLA 138

Query: 142 FKPGQEAVKYQGPRDFQTLENWM 164
            K G    K+ G +D   LE ++
Sbjct: 139 MKNGDVVDKFVGIKDEDQLEAFL 161


>gi|28372543 protein disulfide isomerase-like, testis expressed
           [Homo sapiens]
          Length = 584

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 39/135 (28%), Positives = 60/135 (44%), Gaps = 19/135 (14%)

Query: 81  FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLK 140
           FVMF+APW   C+ L P   +LG KY +   + + +AK+D TA+        +  YP  +
Sbjct: 409 FVMFYAPWSKKCKMLFPLLEELGRKYQN--HSTIIIAKIDVTAND--IQLMYLDRYPFFR 464

Query: 141 LFKPG-QEAVKYQGPRDFQTL--------------ENWMLQTLNEEPVTPEPEVEPPSAP 185
           LF  G Q+AV Y+G    +                E+ +L     E +  E   E    P
Sbjct: 465 LFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDEDELLSVEQNEVIEEEVLAEEKEVP 524

Query: 186 ELKQGLYELSASNFE 200
            +++GL E  +   E
Sbjct: 525 MMRKGLPEQQSPELE 539



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 49/196 (25%), Positives = 93/196 (47%), Gaps = 14/196 (7%)

Query: 137 PTLKLFKPGQEAVKYQGPRD---FQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLY- 192
           P++++     +A +Y+ P D   +++L+ +    L++     +   E P   +  QGL  
Sbjct: 334 PSVQILNLSSDA-RYKMPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKYWD--QGLVK 390

Query: 193 ELSASNFELHV--AQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQH 250
           +L   NF + V   + D F+ F+APW   CK L P  E+L    ++  T+ I K+D T +
Sbjct: 391 QLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVTAN 450

Query: 251 -YELCSGNQVRGYPTLLWFRDG-KKVDQYKGKRDLESLREYVESQLQRTETGATETVTPS 308
             +L     +  YP    F  G ++   YKG+  L+   +++ES ++       E ++  
Sbjct: 451 DIQLM---YLDRYPFFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDEDELLSVE 507

Query: 309 EAPVLAAEPEADKGTV 324
           +  V+  E  A++  V
Sbjct: 508 QNEVIEEEVLAEEKEV 523



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 18/155 (11%)

Query: 284 ESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGIT 341
           ESL+++  S L +    AT+  +  E P        D+G V  L   NF+  +   E   
Sbjct: 357 ESLKKFGRSFLSKN---ATKHQSSEEIPKYW-----DQGLVKQLVGKNFNVVVFDKEKDV 408

Query: 342 FIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLL 401
           F+ FYAPW   CK L P  EEL +K +   + + IA++D TA  +I   Y  R YP   L
Sbjct: 409 FVMFYAPWSKKCKMLFPLLEELGRK-YQNHSTIIIAKIDVTA-NDIQLMYLDR-YPFFRL 465

Query: 402 FRGGKKVS-----EHSGGRDLDSLHRFVLSQAKDE 431
           F  G + +     EH+     D L   + ++ +DE
Sbjct: 466 FPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDE 500


>gi|151101292 thioredoxin domain containing 1 [Homo sapiens]
          Length = 280

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 30/89 (33%), Positives = 45/89 (50%), Gaps = 2/89 (2%)

Query: 205 QGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPT 264
           +GD  I+F+APWC  C+ L P WE  A   E  E V I KVD T+   L     +   PT
Sbjct: 44  EGDWMIEFYAPWCPACQNLQPEWESFAEWGEDLE-VNIAKVDVTEQPGLSGRFIITALPT 102

Query: 265 LLWFRDGKKVDQYKGKRDLESLREYVESQ 293
           +   +DG +  +Y+G R  +    ++  +
Sbjct: 103 IYHCKDG-EFRRYQGPRTKKDFINFISDK 130



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 30/83 (36%), Positives = 42/83 (50%), Gaps = 4/83 (4%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           + F+APWC  CQ LQP W    +     ED +V +AKVD T    +     +   PT+  
Sbjct: 49  IEFYAPWCPACQNLQPEWESFAE---WGEDLEVNIAKVDVTEQPGLSGRFIITALPTIYH 105

Query: 142 FKPGQEAVKYQGPRDFQTLENWM 164
            K G E  +YQGPR  +   N++
Sbjct: 106 CKDG-EFRRYQGPRTKKDFINFI 127



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 27/86 (31%), Positives = 46/86 (53%), Gaps = 3/86 (3%)

Query: 321 KGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVD 380
           +  V  +T+ N+ + + EG   I+FYAPWC  C+ L P WE  +  E+     V IA+VD
Sbjct: 28  RSNVRVITDENWRELL-EGDWMIEFYAPWCPACQNLQPEWESFA--EWGEDLEVNIAKVD 84

Query: 381 CTAERNICSKYSVRGYPTLLLFRGGK 406
            T +  +  ++ +   PT+   + G+
Sbjct: 85  VTEQPGLSGRFIITALPTIYHCKDGE 110


>gi|40254947 thioredoxin-related transmembrane protein 4 [Homo
           sapiens]
          Length = 349

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 39/125 (31%), Positives = 58/125 (46%), Gaps = 8/125 (6%)

Query: 175 PEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGL 234
           PE    PP    ++     ++ASN+ L V +G+  +KF+APWC  C+     WE  A   
Sbjct: 27  PEEAALPPEQSRVQP----MTASNWTL-VMEGEWMLKFYAPWCPSCQQTDSEWEAFAKNG 81

Query: 235 EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYV-ESQ 293
           E  + + +GKVD  Q   L     V   P     +DG    +Y+G    E L+ Y+ E +
Sbjct: 82  EILQ-ISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDG-IFRRYRGPGIFEDLQNYILEKK 139

Query: 294 LQRTE 298
            Q  E
Sbjct: 140 WQSVE 144



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 48/183 (26%), Positives = 77/183 (42%), Gaps = 22/183 (12%)

Query: 31  GGRWGARAQEAAAA--AADGPPAADGEDGQDPHSKHLY--TADMFTHGIQSAAHFVMFFA 86
           GGR G +     AA  AA    A   E    P    +   TA  +T  +      + F+A
Sbjct: 3   GGRCGPQLTALLAAWIAAVAATAGPEEAALPPEQSRVQPMTASNWTL-VMEGEWMLKFYA 61

Query: 87  PWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRG---YPTLKLFK 143
           PWC  CQ+    W        + E  ++ V KV      DV    G+ G     TL  F 
Sbjct: 62  PWCPSCQQTDSEWEAFA---KNGEILQISVGKV------DVIQEPGLSGRFFVTTLPAFF 112

Query: 144 PGQEAV--KYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELK--QGLYELSASNF 199
             ++ +  +Y+GP  F+ L+N++L+    + V P    + P++  +    GL+ +S   +
Sbjct: 113 HAKDGIFRRYRGPGIFEDLQNYILEK-KWQSVEPLTGWKSPASLTMSGMAGLFSISGKIW 171

Query: 200 ELH 202
            LH
Sbjct: 172 HLH 174



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 29/102 (28%), Positives = 45/102 (44%), Gaps = 8/102 (7%)

Query: 304 TVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEEL 363
           T  P EA   A  PE  +  V  +T +N+   + EG   +KFYAPWC  C+     WE  
Sbjct: 24  TAGPEEA---ALPPEQSR--VQPMTASNWT-LVMEGEWMLKFYAPWCPSCQQTDSEWEAF 77

Query: 364 SKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGG 405
           +K     +  + + +VD   E  +  ++ V   P     + G
Sbjct: 78  AKN--GEILQISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDG 117


>gi|50592994 thioredoxin [Homo sapiens]
          Length = 105

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 27/80 (33%), Positives = 41/80 (51%), Gaps = 4/80 (5%)

Query: 334 DTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSV 393
           D   + +  + F A WCG CK + P +  LS+K     + V   EVD    +++ S+  V
Sbjct: 16  DAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEK----YSNVIFLEVDVDDCQDVASECEV 71

Query: 394 RGYPTLLLFRGGKKVSEHSG 413
           +  PT   F+ G+KV E SG
Sbjct: 72  KCMPTFQFFKKGQKVGEFSG 91



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 25/72 (34%), Positives = 39/72 (54%), Gaps = 5/72 (6%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V F A WCG C+ ++P ++ L +KY++     V   +VD     DV S   V+  PT + 
Sbjct: 25  VDFSATWCGPCKMIKPFFHSLSEKYSN-----VIFLEVDVDDCQDVASECEVKCMPTFQF 79

Query: 142 FKPGQEAVKYQG 153
           FK GQ+  ++ G
Sbjct: 80  FKKGQKVGEFSG 91



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 7/86 (8%)

Query: 204 AQGDHFI--KFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRG 261
           A GD  +   F A WCG CK + P +  L+   E    V   +VD     ++ S  +V+ 
Sbjct: 17  AAGDKLVVVDFSATWCGPCKMIKPFFHSLS---EKYSNVIFLEVDVDDCQDVASECEVKC 73

Query: 262 YPTLLWFRDGKKVDQYKG--KRDLES 285
            PT  +F+ G+KV ++ G  K  LE+
Sbjct: 74  MPTFQFFKKGQKVGEFSGANKEKLEA 99


>gi|4759274 thioredoxin-like 1 [Homo sapiens]
          Length = 289

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 44/177 (24%), Positives = 79/177 (44%), Gaps = 26/177 (14%)

Query: 171 EPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQL 230
           +PV  +P+ +P           ELS +   L V      +KF    CG C  +AP +  +
Sbjct: 5   KPVGSDPDFQP-----------ELSGAGSRLAV------VKFTMRGCGPCLRIAPAFSSM 47

Query: 231 ALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYV 290
           +   ++ + V + +VD  Q     + N +   PT L+FR+  ++DQY+G  D   L E +
Sbjct: 48  SN--KYPQAVFL-EVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQG-ADAVGLEEKI 103

Query: 291 ESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENN---FDDTIAEGITFIK 344
           +  L+       +T  P     +   P  +K     L E++   FD+ + +  TF++
Sbjct: 104 KQHLENDPGSNEDTDIPK--GYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLE 158



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 30/103 (29%), Positives = 44/103 (42%), Gaps = 6/103 (5%)

Query: 74  GIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGV 133
           G  S    V F    CG C R+ P ++ + +KY      +V V +   TA ++  SA   
Sbjct: 19  GAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISAT-- 76

Query: 134 RGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPE 176
              PT   F+      +YQG  D   LE  + Q L  +P + E
Sbjct: 77  ---PTFLFFRNKVRIDQYQG-ADAVGLEEKIKQHLENDPGSNE 115



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 19/74 (25%), Positives = 33/74 (44%), Gaps = 4/74 (5%)

Query: 340 ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTL 399
           +  +KF    CG C  +AP +  +S K +P        EVD    +   +  ++   PT 
Sbjct: 24  LAVVKFTMRGCGPCLRIAPAFSSMSNK-YPQAV---FLEVDVHQCQGTAATNNISATPTF 79

Query: 400 LLFRGGKKVSEHSG 413
           L FR   ++ ++ G
Sbjct: 80  LFFRNKVRIDQYQG 93


>gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo
           sapiens]
          Length = 820

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 22/87 (25%), Positives = 43/87 (49%), Gaps = 2/87 (2%)

Query: 67  TADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSD 126
           T + F   + ++   V+F+A W         ++ D+  K      + + + +++C   SD
Sbjct: 392 TEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGT--STMLLTRINCADWSD 449

Query: 127 VCSAQGVRGYPTLKLFKPGQEAVKYQG 153
           VC+ Q V  +P +K++K G+  V Y G
Sbjct: 450 VCTKQNVTEFPIIKMYKKGENPVSYAG 476



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 21/99 (21%), Positives = 47/99 (47%)

Query: 193 ELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 252
           EL+   F   V   D  + F+A W     A   ++  +A+ L+ + T+ + +++C    +
Sbjct: 390 ELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSD 449

Query: 253 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVE 291
           +C+   V  +P +  ++ G+    Y G    E L ++++
Sbjct: 450 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQ 488



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 20/98 (20%), Positives = 49/98 (50%), Gaps = 1/98 (1%)

Query: 327 LTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 386
           LTE  F+ T+    + + FYA W         ++ +++ K   G + + +  ++C    +
Sbjct: 391 LTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVK-LKGTSTMLLTRINCADWSD 449

Query: 387 ICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFV 424
           +C+K +V  +P + +++ G+    ++G    + L +F+
Sbjct: 450 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFI 487


>gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo
           sapiens]
          Length = 825

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 22/87 (25%), Positives = 43/87 (49%), Gaps = 2/87 (2%)

Query: 67  TADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSD 126
           T + F   + ++   V+F+A W         ++ D+  K      + + + +++C   SD
Sbjct: 397 TEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGT--STMLLTRINCADWSD 454

Query: 127 VCSAQGVRGYPTLKLFKPGQEAVKYQG 153
           VC+ Q V  +P +K++K G+  V Y G
Sbjct: 455 VCTKQNVTEFPIIKMYKKGENPVSYAG 481



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 21/99 (21%), Positives = 47/99 (47%)

Query: 193 ELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 252
           EL+   F   V   D  + F+A W     A   ++  +A+ L+ + T+ + +++C    +
Sbjct: 395 ELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSD 454

Query: 253 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVE 291
           +C+   V  +P +  ++ G+    Y G    E L ++++
Sbjct: 455 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQ 493



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 20/98 (20%), Positives = 49/98 (50%), Gaps = 1/98 (1%)

Query: 327 LTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 386
           LTE  F+ T+    + + FYA W         ++ +++ K   G + + +  ++C    +
Sbjct: 396 LTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVK-LKGTSTMLLTRINCADWSD 454

Query: 387 ICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFV 424
           +C+K +V  +P + +++ G+    ++G    + L +F+
Sbjct: 455 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFI 492


>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 15/121 (12%)

Query: 303 ETVTPS-EAPVLAAE------PEADKGTVLALTENNFDDTIAEG---ITFIKFYAPWCGH 352
           E  TPS E  +L  E      PE DK  V+ L++ +F+ ++ E    +  + F A WCG 
Sbjct: 357 EEATPSKEGDILKPEEETMEFPEGDKVKVI-LSKEDFEASLKEAGERLVAVDFSATWCGP 415

Query: 353 CKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHS 412
           C+T+ P +  LS K       V   EVD      +  + ++   PT   ++  +KV E  
Sbjct: 416 CRTIRPFFHALSVKH----EDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELC 471

Query: 413 G 413
           G
Sbjct: 472 G 472



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 8/116 (6%)

Query: 176 EPEVEPPSAPELKQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLAL 232
           +PE E    PE  +    LS  +FE  + +       + F A WCG C+ + P +   AL
Sbjct: 369 KPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH--AL 426

Query: 233 GLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKG--KRDLESL 286
            ++H + V + +VD     E+     +   PT  +++  +KVD+  G  K  LE++
Sbjct: 427 SVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAV 481



 Score = 30.0 bits (66), Expect = 4.3
 Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 5/62 (8%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V F A WCG C+ ++P ++ L  K+       V   +VD     +V     +   PT + 
Sbjct: 406 VDFSATWCGPCRTIRPFFHALSVKHED-----VVFLEVDADNCEEVVRECAIMCVPTFQF 460

Query: 142 FK 143
           +K
Sbjct: 461 YK 462


>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
           sapiens]
          Length = 553

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 15/121 (12%)

Query: 303 ETVTPS-EAPVLAAE------PEADKGTVLALTENNFDDTIAEG---ITFIKFYAPWCGH 352
           E  TPS E  +L  E      PE DK  V+ L++ +F+ ++ E    +  + F A WCG 
Sbjct: 424 EEATPSKEGDILKPEEETMEFPEGDKVKVI-LSKEDFEASLKEAGERLVAVDFSATWCGP 482

Query: 353 CKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHS 412
           C+T+ P +  LS K       V   EVD      +  + ++   PT   ++  +KV E  
Sbjct: 483 CRTIRPFFHALSVKH----EDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELC 538

Query: 413 G 413
           G
Sbjct: 539 G 539



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 8/116 (6%)

Query: 176 EPEVEPPSAPELKQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLAL 232
           +PE E    PE  +    LS  +FE  + +       + F A WCG C+ + P +   AL
Sbjct: 436 KPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH--AL 493

Query: 233 GLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKG--KRDLESL 286
            ++H + V + +VD     E+     +   PT  +++  +KVD+  G  K  LE++
Sbjct: 494 SVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAV 548



 Score = 30.0 bits (66), Expect = 4.3
 Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 5/62 (8%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V F A WCG C+ ++P ++ L  K+       V   +VD     +V     +   PT + 
Sbjct: 473 VDFSATWCGPCRTIRPFFHALSVKHED-----VVFLEVDADNCEEVVRECAIMCVPTFQF 527

Query: 142 FK 143
           +K
Sbjct: 528 YK 529


>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 15/121 (12%)

Query: 303 ETVTPS-EAPVLAAE------PEADKGTVLALTENNFDDTIAEG---ITFIKFYAPWCGH 352
           E  TPS E  +L  E      PE DK  V+ L++ +F+ ++ E    +  + F A WCG 
Sbjct: 357 EEATPSKEGDILKPEEETMEFPEGDKVKVI-LSKEDFEASLKEAGERLVAVDFSATWCGP 415

Query: 353 CKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHS 412
           C+T+ P +  LS K       V   EVD      +  + ++   PT   ++  +KV E  
Sbjct: 416 CRTIRPFFHALSVKH----EDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELC 471

Query: 413 G 413
           G
Sbjct: 472 G 472



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 8/116 (6%)

Query: 176 EPEVEPPSAPELKQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLAL 232
           +PE E    PE  +    LS  +FE  + +       + F A WCG C+ + P +   AL
Sbjct: 369 KPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH--AL 426

Query: 233 GLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKG--KRDLESL 286
            ++H + V + +VD     E+     +   PT  +++  +KVD+  G  K  LE++
Sbjct: 427 SVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAV 481



 Score = 30.0 bits (66), Expect = 4.3
 Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 5/62 (8%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V F A WCG C+ ++P ++ L  K+       V   +VD     +V     +   PT + 
Sbjct: 406 VDFSATWCGPCRTIRPFFHALSVKHED-----VVFLEVDADNCEEVVRECAIMCVPTFQF 460

Query: 142 FK 143
           +K
Sbjct: 461 YK 462


>gi|94421469 disulfide isomerase [Homo sapiens]
          Length = 360

 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 36/151 (23%), Positives = 68/151 (45%), Gaps = 16/151 (10%)

Query: 289 YVESQLQRTETGATETVTPSEA---PVLAAEPEADKGT------VLALTENNFDDTIAEG 339
           Y E ++  ++   TE    +E+   P +  E     G       +L ++++  D     G
Sbjct: 148 YTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNG 207

Query: 340 --ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYP 397
              T + FY PWC    +LAP +  L  + FP L       +D +   ++ +++     P
Sbjct: 208 SDCTLVLFYTPWCRFSASLAPHFNSL-PRAFPAL---HFLALDASQHSSLSTRFGTVAVP 263

Query: 398 TLLLFRGGKKVSE-HSGGRDLDSLHRFVLSQ 427
            +LLF+G K ++  +   R L++L  F+ +Q
Sbjct: 264 NILLFQGAKPMARFNHTDRTLETLKIFIFNQ 294



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 22/106 (20%), Positives = 45/106 (42%), Gaps = 7/106 (6%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141
           V+F+ PWC     L P +N L   + ++     +   +D + HS + +  G    P + L
Sbjct: 213 VLFYTPWCRFSASLAPHFNSLPRAFPAL-----HFLALDASQHSSLSTRFGTVAVPNILL 267

Query: 142 FKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPEL 187
           F+  +   ++      +TLE   +   N+  +  +  V    A ++
Sbjct: 268 FQGAKPMARFN--HTDRTLETLKIFIFNQTGIEAKKNVVVTQADQI 311



 Score = 33.9 bits (76), Expect = 0.29
 Identities = 26/109 (23%), Positives = 48/109 (44%), Gaps = 7/109 (6%)

Query: 210 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFR 269
           + F+ PWC    +LAP +  L         +    +D +QH  L +       P +L F+
Sbjct: 213 VLFYTPWCRFSASLAPHFNSLPRAF---PALHFLALDASQHSSLSTRFGTVAVPNILLFQ 269

Query: 270 DGKKVDQYK-GKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEP 317
             K + ++    R LE+L+ ++ +Q   T   A + V  ++A  +   P
Sbjct: 270 GAKPMARFNHTDRTLETLKIFIFNQ---TGIEAKKNVVVTQADQIGPLP 315


>gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo
           sapiens]
          Length = 258

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 8/71 (11%)

Query: 343 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSV------RGY 396
           ++F+A W   C++ AP + +LS K      G+   +VD     ++ ++Y V      +  
Sbjct: 122 VEFFANWSNDCQSFAPIYADLSLKY--NCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQL 179

Query: 397 PTLLLFRGGKK 407
           PTL+LF+GGK+
Sbjct: 180 PTLILFQGGKE 190



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 3/72 (4%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYN--SMEDAKVYVAK-VDCTAHSDVCSAQGVRGYPT 138
           V FFA W   CQ   P + DL  KYN   +   KV V +  D +    V ++   +  PT
Sbjct: 122 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLPT 181

Query: 139 LKLFKPGQEAVK 150
           L LF+ G+EA++
Sbjct: 182 LILFQGGKEAMR 193



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 21/70 (30%), Positives = 38/70 (54%), Gaps = 7/70 (10%)

Query: 210 IKFFAPWCGHCKALAPTWEQLAL-----GLEHSETVKIGK-VDCTQHYELCSGNQVRGYP 263
           ++FFA W   C++ AP +  L+L     GL   + V +G+  D +  Y++ +    +  P
Sbjct: 122 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGK-VDVGRYTDVSTRYKVSTSPLTKQLP 180

Query: 264 TLLWFRDGKK 273
           TL+ F+ GK+
Sbjct: 181 TLILFQGGKE 190


>gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo
           sapiens]
          Length = 296

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 8/71 (11%)

Query: 343 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSV------RGY 396
           ++F+A W   C++ AP + +LS K      G+   +VD     ++ ++Y V      +  
Sbjct: 160 VEFFANWSNDCQSFAPIYADLSLKY--NCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQL 217

Query: 397 PTLLLFRGGKK 407
           PTL+LF+GGK+
Sbjct: 218 PTLILFQGGKE 228



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 3/72 (4%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYN--SMEDAKVYVAK-VDCTAHSDVCSAQGVRGYPT 138
           V FFA W   CQ   P + DL  KYN   +   KV V +  D +    V ++   +  PT
Sbjct: 160 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLPT 219

Query: 139 LKLFKPGQEAVK 150
           L LF+ G+EA++
Sbjct: 220 LILFQGGKEAMR 231



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 21/70 (30%), Positives = 38/70 (54%), Gaps = 7/70 (10%)

Query: 210 IKFFAPWCGHCKALAPTWEQLAL-----GLEHSETVKIGK-VDCTQHYELCSGNQVRGYP 263
           ++FFA W   C++ AP +  L+L     GL   + V +G+  D +  Y++ +    +  P
Sbjct: 160 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGK-VDVGRYTDVSTRYKVSTSPLTKQLP 218

Query: 264 TLLWFRDGKK 273
           TL+ F+ GK+
Sbjct: 219 TLILFQGGKE 228


>gi|95113651 glutaredoxin 3 [Homo sapiens]
          Length = 335

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/106 (26%), Positives = 44/106 (41%), Gaps = 9/106 (8%)

Query: 308 SEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKE 367
           +EA V A E     G    L         A+ +  + F+APW   C  +     EL+ KE
Sbjct: 6   AEAAVAAVEEVGSAGQFEELLRLK-----AKSLLVVHFWAPWAPQCAQMNEVMAELA-KE 59

Query: 368 FPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSG 413
            P ++ VK+   +      +  KY +   PT L F+  +K+    G
Sbjct: 60  LPQVSFVKL---EAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDG 102



 Score = 37.4 bits (85), Expect = 0.027
 Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 9/73 (12%)

Query: 210 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKI---GKVDCTQHYELCSGNQVRGYPTLL 266
           + F+APW   C  +     +LA  L     VK+   G  + ++ YE+ S       PT L
Sbjct: 36  VHFWAPWAPQCAQMNEVMAELAKELPQVSFVKLEAEGVPEVSEKYEISS------VPTFL 89

Query: 267 WFRDGKKVDQYKG 279
           +F++ +K+D+  G
Sbjct: 90  FFKNSQKIDRLDG 102


>gi|54633317 thioredoxin domain containing 11 [Homo sapiens]
          Length = 958

 Score = 38.5 bits (88), Expect = 0.012
 Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 2/75 (2%)

Query: 199 FELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQ 258
           +E+ + + D  + ++APWCG C +L   + QLA  L   +T  + ++D +Q+ +L     
Sbjct: 674 WEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLP-MDTFTVARIDVSQN-DLPWEFM 731

Query: 259 VRGYPTLLWFRDGKK 273
           V   PT+L+F   +K
Sbjct: 732 VDRLPTVLFFPCNRK 746



 Score = 32.7 bits (73), Expect = 0.66
 Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 7/102 (6%)

Query: 328 TENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNI 387
           T+  ++  + +    + +YAPWCG C +L   + +L+ +  P +    +A +D  ++ ++
Sbjct: 670 TDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLA-RNLP-MDTFTVARID-VSQNDL 726

Query: 388 CSKYSVRGYPTLLLFRGGKKVSEHSGGRD----LDSLHRFVL 425
             ++ V   PT+L F   +K        D    L +L RF+L
Sbjct: 727 PWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFIL 768



 Score = 30.8 bits (68), Expect = 2.5
 Identities = 28/120 (23%), Positives = 53/120 (44%), Gaps = 17/120 (14%)

Query: 82  VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGY-PTLK 140
           + F+APWCG     +    ++    + + D  ++VA ++C  +   C  Q    Y P + 
Sbjct: 130 LFFYAPWCGQSIAARA---EIEQAASRLSDQVLFVA-INCWWNQGKCRKQKHFFYFPVIY 185

Query: 141 LFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFE 200
           L+      ++Y+GP     +E ++ + +       +P +  PS  EL   L     SN+E
Sbjct: 186 LYHRSFGPIEYKGPMSAVYIEKFVRRVM-------KPLLYIPSQSELLDFL-----SNYE 233



 Score = 30.4 bits (67), Expect = 3.3
 Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 9/122 (7%)

Query: 62  SKHLYT---ADMFTHGI-QSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVA 117
           S+HL T    D F   + Q     ++++APWCG C  L   +  L     ++      VA
Sbjct: 661 SQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLA---RNLPMDTFTVA 717

Query: 118 KVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQ-TLENWMLQTLNEEPVTPE 176
           ++D  + +D+     V   PT+  F   ++ +  + P D   TL N +   L+       
Sbjct: 718 RID-VSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPASS 776

Query: 177 PE 178
           P+
Sbjct: 777 PQ 778


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,598,386
Number of Sequences: 37866
Number of extensions: 889892
Number of successful extensions: 4087
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 3760
Number of HSP's gapped (non-prelim): 253
length of query: 432
length of database: 18,247,518
effective HSP length: 105
effective length of query: 327
effective length of database: 14,271,588
effective search space: 4666809276
effective search space used: 4666809276
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.