BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|42794771 thioredoxin domain containing 5 isoform 1 precursor [Homo sapiens] (432 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|42794771 thioredoxin domain containing 5 isoform 1 precursor ... 903 0.0 gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo sap... 674 0.0 gi|5031973 protein disulfide isomerase A6 [Homo sapiens] 145 5e-35 gi|4758304 protein disulfide isomerase A4 [Homo sapiens] 144 1e-34 gi|5803121 protein disulfide isomerase A5 [Homo sapiens] 132 5e-31 gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo s... 120 2e-27 gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens] 101 1e-21 gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo s... 86 5e-17 gi|38505222 thioredoxin domain containing 10 [Homo sapiens] 82 7e-16 gi|94966757 protein disulfide isomerase A2 [Homo sapiens] 80 5e-15 gi|52487191 thioredoxin domain containing 4 (endoplasmic reticul... 68 2e-11 gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo sap... 64 3e-10 gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo sap... 64 3e-10 gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens] 61 2e-09 gi|21361403 thioredoxin 2 precursor [Homo sapiens] 54 2e-07 gi|28372543 protein disulfide isomerase-like, testis expressed [... 54 2e-07 gi|151101292 thioredoxin domain containing 1 [Homo sapiens] 53 5e-07 gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sa... 53 5e-07 gi|50592994 thioredoxin [Homo sapiens] 51 2e-06 gi|4759274 thioredoxin-like 1 [Homo sapiens] 48 2e-05 gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo sa... 47 4e-05 gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo sa... 47 4e-05 gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 47 4e-05 gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 47 4e-05 gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 47 4e-05 gi|94421469 disulfide isomerase [Homo sapiens] 45 1e-04 gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo sa... 43 5e-04 gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo sapi... 43 5e-04 gi|95113651 glutaredoxin 3 [Homo sapiens] 42 0.001 gi|54633317 thioredoxin domain containing 11 [Homo sapiens] 39 0.012 >gi|42794771 thioredoxin domain containing 5 isoform 1 precursor [Homo sapiens] Length = 432 Score = 903 bits (2334), Expect = 0.0 Identities = 432/432 (100%), Positives = 432/432 (100%) Query: 1 MPARPGRLLPLLARPAALTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAADGEDGQDP 60 MPARPGRLLPLLARPAALTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAADGEDGQDP Sbjct: 1 MPARPGRLLPLLARPAALTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAADGEDGQDP 60 Query: 61 HSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVD 120 HSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVD Sbjct: 61 HSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVD 120 Query: 121 CTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVE 180 CTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVE Sbjct: 121 CTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVE 180 Query: 181 PPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETV 240 PPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETV Sbjct: 181 PPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETV 240 Query: 241 KIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETG 300 KIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETG Sbjct: 241 KIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETG 300 Query: 301 ATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTW 360 ATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTW Sbjct: 301 ATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTW 360 Query: 361 EELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSL 420 EELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSL Sbjct: 361 EELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSL 420 Query: 421 HRFVLSQAKDEL 432 HRFVLSQAKDEL Sbjct: 421 HRFVLSQAKDEL 432 >gi|224493972 thioredoxin domain containing 5 isoform 3 [Homo sapiens] Length = 324 Score = 674 bits (1740), Expect = 0.0 Identities = 324/324 (100%), Positives = 324/324 (100%) Query: 109 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL 168 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL Sbjct: 1 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTL 60 Query: 169 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE 228 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE Sbjct: 61 NEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWE 120 Query: 229 QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE 288 QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE Sbjct: 121 QLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLRE 180 Query: 289 YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP 348 YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP Sbjct: 181 YVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAP 240 Query: 349 WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV 408 WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV Sbjct: 241 WCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV 300 Query: 409 SEHSGGRDLDSLHRFVLSQAKDEL 432 SEHSGGRDLDSLHRFVLSQAKDEL Sbjct: 301 SEHSGGRDLDSLHRFVLSQAKDEL 324 Score = 204 bits (518), Expect = 2e-52 Identities = 106/235 (45%), Positives = 139/235 (59%), Gaps = 10/235 (4%) Query: 67 TADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSD 126 +A F + HF+ FFAPWCGHC+ L PTW L E K + KVDCT H + Sbjct: 87 SASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVK--IGKVDCTQHYE 144 Query: 127 VCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNE------EPVTPEPEVE 180 +CS VRGYPTL F+ G++ +Y+G RD ++L ++ L E VTP Sbjct: 145 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPV 204 Query: 181 PPSAPELKQG-LYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLA-LGLEHSE 238 + PE +G + L+ +NF+ +A+G FIKF+APWCGHCK LAPTWE+L+ Sbjct: 205 LAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLA 264 Query: 239 TVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 293 VKI +VDCT +CS VRGYPTLL FR GKKV ++ G RDL+SL +V SQ Sbjct: 265 GVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQ 319 Score = 94.0 bits (232), Expect = 2e-19 Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 1/122 (0%) Query: 50 PAADGEDGQDPHSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSM 109 P E D + T + F I F+ F+APWCGHC+ L PTW +L K Sbjct: 203 PVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKK-EFP 261 Query: 110 EDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLN 169 A V +A+VDCTA ++CS VRGYPTL LF+ G++ ++ G RD +L ++L Sbjct: 262 GLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAK 321 Query: 170 EE 171 +E Sbjct: 322 DE 323 >gi|5031973 protein disulfide isomerase A6 [Homo sapiens] Length = 440 Score = 145 bits (367), Expect = 5e-35 Identities = 81/237 (34%), Positives = 128/237 (54%), Gaps = 23/237 (9%) Query: 193 ELSASNFELHVAQGDHF--IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQH 250 EL+ SNF V Q D ++F+APWCGHC+ L P W++ A L+ + VK+G VD +H Sbjct: 29 ELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALK--DVVKVGAVDADKH 86 Query: 251 YELCSGNQVRGYPTLLWFRDGK-KVDQYKGKRD--------LESLREYVESQLQRTETGA 301 + L V+G+PT+ F K + + Y+G R L +LR+ V+ +L G Sbjct: 87 HSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGY 146 Query: 302 TETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGITFIKFYAPWCGHCKTLAPT 359 + + K V+ LT+++FD + +E + ++FYAPWCGHCK L P Sbjct: 147 SSGKQ-------GRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPE 199 Query: 360 WEELSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGR 415 W + + G VK+A VD T + + S+Y +RG+PT+ +F+ G+ ++ GGR Sbjct: 200 WAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGR 256 Score = 109 bits (272), Expect = 6e-24 Identities = 68/213 (31%), Positives = 103/213 (48%), Gaps = 17/213 (7%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V F+APWCGHCQRL P W +++D V V VD H + GV+G+PT+K+ Sbjct: 48 VEFYAPWCGHCQRLTPEWKKAA---TALKDV-VKVGAVDADKHHSLGGQYGVQGFPTIKI 103 Query: 142 FKPGQEAVK-YQGPRDFQTLENWMLQTLNE--------EPVTPEPEVEPPSAPELKQGLY 192 F + + YQG R + + + L L + + S K+ + Sbjct: 104 FGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVI 163 Query: 193 ELSASNFELHVAQGDH--FIKFFAPWCGHCKALAPTWEQLALGLEHSE--TVKIGKVDCT 248 EL+ +F+ +V + ++F+APWCGHCK L P W A ++ VK+ VD T Sbjct: 164 ELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDAT 223 Query: 249 QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKR 281 + L S +RG+PT+ F+ G+ Y G R Sbjct: 224 VNQVLASRYGIRGFPTIKIFQKGESPVDYDGGR 256 Score = 78.2 bits (191), Expect = 1e-14 Identities = 34/95 (35%), Positives = 51/95 (53%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V F+APWCGHC+ L+P W + KV +A VD T + + S G+RG+PT+K+ Sbjct: 183 VEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKI 242 Query: 142 FKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPE 176 F+ G+ V Y G R + + L ++ PE Sbjct: 243 FQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPE 277 >gi|4758304 protein disulfide isomerase A4 [Homo sapiens] Length = 645 Score = 144 bits (364), Expect = 1e-34 Identities = 89/280 (31%), Positives = 145/280 (51%), Gaps = 24/280 (8%) Query: 152 QGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDH-FI 210 +GP + + ++ EE + E E + + G+ L+ +NF+ VA D + Sbjct: 25 EGPDEDSSNRENAIEDEEEEEEEDDDEEEDDLEVKEENGVLVLNDANFDNFVADKDTVLL 84 Query: 211 KFFAPWCGHCKALAPTWEQLALGLEHSET-VKIGKVDCTQHYELCSGNQVRGYPTLLWFR 269 +F+APWCGHCK AP +E++A L+ + + + K+D T L S V GYPT+ + Sbjct: 85 EFYAPWCGHCKQFAPEYEKIANILKDKDPPIPVAKIDATSASVLASRFDVSGYPTIKILK 144 Query: 270 DGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTE 329 G+ VD Y+G R E + V Q P PE L LT+ Sbjct: 145 KGQAVD-YEGSRTQEEIVAKVREVSQ---------------PDWTPPPEV----TLVLTK 184 Query: 330 NNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 388 NFD+ + + I ++FYAPWCGHCK LAP +E+ +K+ + +A+VD TAE ++ Sbjct: 185 ENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLA 244 Query: 389 SKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQA 428 ++ V GYPTL +FR G+ +++G R+ + +++ Q+ Sbjct: 245 KRFDVSGYPTLKIFRKGRPY-DYNGPREKYGIVDYMIEQS 283 Score = 126 bits (316), Expect = 4e-29 Identities = 78/212 (36%), Positives = 109/212 (51%), Gaps = 17/212 (8%) Query: 84 FFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFK 143 F+APWCGHC++ P + + + +D + VAK+D T+ S + S V GYPT+K+ K Sbjct: 86 FYAPWCGHCKQFAPEYEKIANILKD-KDPPIPVAKIDATSASVLASRFDVSGYPTIKILK 144 Query: 144 PGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHV 203 GQ AV Y+G R EE V EV P + L+ NF+ V Sbjct: 145 KGQ-AVDYEGSR------------TQEEIVAKVREVSQPDWTPPPEVTLVLTKENFDEVV 191 Query: 204 AQGD-HFIKFFAPWCGHCKALAPTWEQLALGL-EHSETVKIGKVDCTQHYELCSGNQVRG 261 D ++F+APWCGHCK LAP +E+ A L + S + + KVD T +L V G Sbjct: 192 NDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSG 251 Query: 262 YPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 293 YPTL FR G+ D Y G R+ + +Y+ Q Sbjct: 252 YPTLKIFRKGRPYD-YNGPREKYGIVDYMIEQ 282 Score = 87.8 bits (216), Expect = 2e-17 Identities = 61/173 (35%), Positives = 89/173 (51%), Gaps = 21/173 (12%) Query: 271 GKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTEN 330 GKK + D ++LRE+V + + G + V S+ PV P+ +KG V + Sbjct: 483 GKKFAMEPEEFDSDTLREFVTA----FKKGKLKPVIKSQ-PV----PKNNKGPVKVVVGK 533 Query: 331 NFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNIC 388 FD + + I+FYAPWCGHCK L P + L+KK + G G+ IA++D TA Sbjct: 534 TFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKK-YKGQKGLVIAKMDATANDVPS 592 Query: 389 SKYSVRGYPTLLLFRGGKK---VSEHSGGRDLDSLHRFV------LSQAKDEL 432 +Y V G+PT+ G K V G RDL+ L +F+ LS+ K+EL Sbjct: 593 DRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTKEEL 645 Score = 69.7 bits (169), Expect = 5e-12 Identities = 34/85 (40%), Positives = 51/85 (60%), Gaps = 2/85 (2%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V F+APWCGHC++L P + K S + +AKVD TA +D+ V GYPTLK+ Sbjct: 199 VEFYAPWCGHCKKLAPEYEKAA-KELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKI 257 Query: 142 FKPGQEAVKYQGPRDFQTLENWMLQ 166 F+ G+ Y GPR+ + ++M++ Sbjct: 258 FRKGR-PYDYNGPREKYGIVDYMIE 281 Score = 65.9 bits (159), Expect = 7e-11 Identities = 36/98 (36%), Positives = 55/98 (56%), Gaps = 6/98 (6%) Query: 207 DHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLL 266 D I+F+APWCGHCK L P + LA + + + I K+D T + +V G+PT+ Sbjct: 545 DVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTIY 604 Query: 267 WFRDGKKVDQYK---GKRDLESLREYVE---SQLQRTE 298 + G K + K G RDLE L +++E ++L RT+ Sbjct: 605 FAPSGDKKNPVKFEGGDRDLEHLSKFIEEHATKLSRTK 642 Score = 60.8 bits (146), Expect = 2e-09 Identities = 30/86 (34%), Positives = 49/86 (56%), Gaps = 5/86 (5%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 + F+APWCGHC++L+P +N L KY + + +AK+D TA+ V G+PT+ Sbjct: 548 IEFYAPWCGHCKQLEPVYNSLAKKYKGQKG--LVIAKMDATANDVPSDRYKVEGFPTIYF 605 Query: 142 FKPG--QEAVKYQ-GPRDFQTLENWM 164 G + VK++ G RD + L ++ Sbjct: 606 APSGDKKNPVKFEGGDRDLEHLSKFI 631 >gi|5803121 protein disulfide isomerase A5 [Homo sapiens] Length = 519 Score = 132 bits (333), Expect = 5e-31 Identities = 109/385 (28%), Positives = 175/385 (45%), Gaps = 49/385 (12%) Query: 48 GPPAADGEDGQDPHSK---HLYTADMFTHGIQSAAH--FVMFFAPWCGHCQRLQPTWNDL 102 GPP + +DP +K HL + F ++ +MF+APWC C+R+ P + Sbjct: 140 GPPLWE----EDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKA 195 Query: 103 GDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQG-PRDFQTLE 161 + A + V + ++ VRG+PT+ F+ G+ +Y + + Sbjct: 196 ATQLRG--HAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIV 253 Query: 162 NWMLQTLNEEPVTPEPEVEPPSAPELKQG--LYELSASNFELHVAQGDH-FIKFFAPWCG 218 W+ + P P+P+V P P +G +Y L+ +F+ V + + F APWCG Sbjct: 254 EWL-----KNPQPPQPQV--PETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCG 306 Query: 219 HCKALAPTWEQLALGLEHSETVKIG---KVDCTQHYELCSGNQVRGYPTLLWFRDGKKVD 275 HCK + P +E+ A L H E G VD T + L + +PTL +F++G+K Sbjct: 307 HCKKMKPEFEKAAEAL-HGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEK-- 363 Query: 276 QYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEP--EADKGTVLALTENNFD 333 Y L RT+ E + EAP EP E + +VL L +NF Sbjct: 364 -------------YAVPVL-RTKKKFLEWMQNPEAPP-PPEPTWEEQQTSVLHLVGDNFR 408 Query: 334 DTIAEGI-TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN--ICSK 390 +T+ + T + FYAPWC HCK + P + + F + A VDC ++N +C + Sbjct: 409 ETLKKKKHTLVMFYAPWCPHCKKVIPHF-TATADAFKDDRKIACAAVDCVKDKNQDLCQQ 467 Query: 391 YSVRGYPTLLLFRGGKKVSEHSGGR 415 +V+GYPT + GK ++ R Sbjct: 468 EAVKGYPTFHYYHYGKFAEKYDSDR 492 Score = 110 bits (276), Expect = 2e-24 Identities = 68/234 (29%), Positives = 106/234 (45%), Gaps = 15/234 (6%) Query: 64 HLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTA 123 HL D + ++ VMF APWCGHC++++P + + + D+ +A VD T Sbjct: 280 HLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATV 339 Query: 124 HSDVCSAQGVRGYPTLKLFKPGQEAVKYQGP--RDFQTLENWMLQTLNEEPVTPEPEVEP 181 + + + +PTLK FK G+ KY P R + WM E P PEP E Sbjct: 340 NKALAERFHISEFPTLKYFKNGE---KYAVPVLRTKKKFLEWMQNP--EAPPPPEPTWE- 393 Query: 182 PSAPELKQGLYELSASNFELHVAQGDH-FIKFFAPWCGHCKALAPTWEQLALGLEHSETV 240 E + + L NF + + H + F+APWC HCK + P + A + + Sbjct: 394 ----EQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKI 449 Query: 241 KIGKVDCT--QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVES 292 VDC ++ +LC V+GYPT ++ GK ++Y R Y+ + Sbjct: 450 ACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRA 503 >gi|24308127 DnaJ (Hsp40) homolog, subfamily C, member 10 [Homo sapiens] Length = 793 Score = 120 bits (302), Expect = 2e-27 Identities = 86/333 (25%), Positives = 140/333 (42%), Gaps = 68/333 (20%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V FFAPWC C+ L P + +++ ++ +DCT H +C+ ++ YPT + Sbjct: 473 VDFFAPWCPPCRALLPELR----RASNLLYGQLKFGTLDCTVHEGLCNMYNIQAYPTTVV 528 Query: 142 FKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFEL 201 F +Y+G + + ++ +N V+ L+ + F Sbjct: 529 FNQ-SNIHEYEGHHSAEQILEFIEDLMNPSVVS-------------------LTPTTFNE 568 Query: 202 HVAQGDH----FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGN 257 V Q H + F++PWC C+ L P W+++A L + + +G +DC Q++ C+ Sbjct: 569 LVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTL--TGLINVGSIDCQQYHSFCAQE 626 Query: 258 QVRGYPTLLWF----RDGKKVDQYKG-KRDLESLREYVESQLQRTETGATETVTPSEAPV 312 V+ YP + +F Y G RD SLR + L + T Sbjct: 627 NVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFLPQVSTD------------ 674 Query: 313 LAAEPEADKGTVLALTENNFDDTIAEGIT--FIKFYAPWCGHCKTLAPTWEELSKKEFPG 370 LT F + + +G I FYAPWCG C+ AP +E L++ Sbjct: 675 --------------LTPQTFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARM---- 716 Query: 371 LAG-VKIAEVDCTAERNICSKYSVRGYPTLLLF 402 + G VK +VDC A C K +R YPT+ + Sbjct: 717 IKGKVKAGKVDCQAYAQTCQKAGIRAYPTVKFY 749 Score = 101 bits (251), Expect = 2e-21 Identities = 76/313 (24%), Positives = 139/313 (44%), Gaps = 63/313 (20%) Query: 109 MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQ---GPRDFQTLENWML 165 +++ + V + DC++ D+CS V P+L +FK GQ +Y+ G + + + Sbjct: 391 LKNDHIQVGRFDCSSAPDICSNLYVF-QPSLAVFK-GQGTKEYEIHHGKKILYDILAFAK 448 Query: 166 QTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAP 225 +++N T P+ P + E + FFAPWC C+AL P Sbjct: 449 ESVNSHVTTLGPQNFPANDKE--------------------PWLVDFFAPWCPPCRALLP 488 Query: 226 TWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLES 285 + A L + + +K G +DCT H LC+ ++ YPT + F + +Y+G E Sbjct: 489 ELRR-ASNLLYGQ-LKFGTLDCTVHEGLCNMYNIQAYPTTVVFNQSN-IHEYEGHHSAEQ 545 Query: 286 LREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG----IT 341 + E++E + + PS V++LT F++ + + + Sbjct: 546 ILEFIE-----------DLMNPS---------------VVSLTPTTFNELVTQRKHNEVW 579 Query: 342 FIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLL 401 + FY+PWC C+ L P W+ ++ + GL + + +DC + C++ +V+ YP + Sbjct: 580 MVDFYSPWCHPCQVLMPEWKRMA-RTLTGL--INVGSIDCQQYHSFCAQENVQRYPEIRF 636 Query: 402 F--RGGKKVSEHS 412 F + K HS Sbjct: 637 FPPKSNKAYHYHS 649 Score = 91.7 bits (226), Expect = 1e-18 Identities = 60/207 (28%), Positives = 90/207 (43%), Gaps = 32/207 (15%) Query: 69 DMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVC 128 ++ T + V F++PWC CQ L P W + + + V +DC + C Sbjct: 568 ELVTQRKHNEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGL----INVGSIDCQQYHSFC 623 Query: 129 SAQGVRGYPTLKLFKPGQEAV----KYQG-PRDFQTLENWMLQTLNEEPVTPEPEVEPPS 183 + + V+ YP ++ F P Y G RD +L W L L P+V Sbjct: 624 AQENVQRYPEIRFFPPKSNKAYHYHSYNGWNRDAYSLRIWGLGFL--------PQVSTDL 675 Query: 184 APELKQGLYELSASNFELHVAQGDHF--IKFFAPWCGHCKALAPTWEQLALGLEHSETVK 241 P+ F V QG + I F+APWCG C+ AP +E LA ++ VK Sbjct: 676 TPQ-----------TFSEKVLQGKNHWVIDFYAPWCGPCQNFAPEFELLARMIKGK--VK 722 Query: 242 IGKVDCTQHYELCSGNQVRGYPTLLWF 268 GKVDC + + C +R YPT+ ++ Sbjct: 723 AGKVDCQAYAQTCQKAGIRAYPTVKFY 749 Score = 75.5 bits (184), Expect = 9e-14 Identities = 38/111 (34%), Positives = 58/111 (52%), Gaps = 4/111 (3%) Query: 320 DKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAE 378 D ++ L FD + G + F+ FY+P C HC LAPTW + + KE GL ++I Sbjct: 127 DDPEIITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFA-KEVDGL--LRIGA 183 Query: 379 VDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAK 429 V+C +R +C V YP+L +FR G ++ G R +SL F + + Sbjct: 184 VNCGDDRMLCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESLVSFAMQHVR 234 Score = 68.6 bits (166), Expect = 1e-11 Identities = 58/201 (28%), Positives = 81/201 (40%), Gaps = 29/201 (14%) Query: 194 LSASNFELHVAQGD-HFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 252 L F+ V G+ F+ F++P C HC LAPTW A E ++IG V+C Sbjct: 134 LERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWRDFAK--EVDGLLRIGAVNCGDDRM 191 Query: 253 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPV 312 LC V YP+L FR G +Y G R ESL V +Q + TE T + Sbjct: 192 LCRMKGVNSYPSLFIFRSGMAPVKYHGDRSKESL---VSFAMQHVRSTVTELWTGNFV-- 246 Query: 313 LAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLA 372 N+ A GI ++ + G C T + T LS GL Sbjct: 247 -----------------NSIQTAFAAGIGWLITFCSKGGDCLT-SQTRLRLSGM-LDGL- 286 Query: 373 GVKIAEVDCTAERNICSKYSV 393 V + +DC + N+C + Sbjct: 287 -VNVGWMDCATQDNLCKSLDI 306 Score = 65.5 bits (158), Expect = 9e-11 Identities = 46/174 (26%), Positives = 74/174 (42%), Gaps = 22/174 (12%) Query: 81 FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLK 140 FV F++P C HC L PTW D + D + + V+C +C +GV YP+L Sbjct: 150 FVNFYSPGCSHCHDLAPTWRDFAKEV----DGLLRIGAVNCGDDRMLCRMKGVNSYPSLF 205 Query: 141 LFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFE 200 +F+ G VKY G R ++L ++ +Q + + EL G + ++ + Sbjct: 206 IFRSGMAPVKYHGDRSKESLVSFAMQHVRS------------TVTELWTGNF---VNSIQ 250 Query: 201 LHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELC 254 A G ++ F G C + +L L V +G +DC LC Sbjct: 251 TAFAAGIGWLITFCSKGGDC---LTSQTRLRLSGMLDGLVNVGWMDCATQDNLC 301 >gi|21361657 protein disulfide-isomerase A3 precursor [Homo sapiens] Length = 505 Score = 101 bits (252), Expect = 1e-21 Identities = 55/127 (43%), Positives = 76/127 (59%), Gaps = 9/127 (7%) Query: 307 PSEAPVLAAEPEADKGTVLALTENNFD----DTIAEGITFIKFYAPWCGHCKTLAPTWEE 362 P A +LAA A VL LT++NF+ DT + G+ ++F+APWCGHCK LAP +E Sbjct: 10 PGVALLLAAARLAAASDVLELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69 Query: 363 LSKKEFPGLAG-VKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLH 421 + + L G V +A+VDCTA N C+KY V GYPTL +FR G++ + G R D + Sbjct: 70 AATR----LKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIV 125 Query: 422 RFVLSQA 428 + QA Sbjct: 126 SHLKKQA 132 Score = 84.7 bits (208), Expect = 1e-16 Identities = 38/74 (51%), Positives = 50/74 (67%), Gaps = 4/74 (5%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V FFAPWCGHC+RL P + + + V +AKVDCTA+++ C+ GV GYPTLK+ Sbjct: 50 VEFFAPWCGHCKRLAPEYEAAATRLKGI----VPLAKVDCTANTNTCNKYGVSGYPTLKI 105 Query: 142 FKPGQEAVKYQGPR 155 F+ G+EA Y GPR Sbjct: 106 FRDGEEAGAYDGPR 119 Score = 83.2 bits (204), Expect = 4e-16 Identities = 43/105 (40%), Positives = 60/105 (57%), Gaps = 6/105 (5%) Query: 193 ELSASNFELHVAQ----GDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCT 248 EL+ NFE ++ G ++FFAPWCGHCK LAP +E A L+ V + KVDCT Sbjct: 29 ELTDDNFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAKVDCT 86 Query: 249 QHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQ 293 + C+ V GYPTL FRDG++ Y G R + + +++ Q Sbjct: 87 ANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQ 131 Score = 78.2 bits (191), Expect = 1e-14 Identities = 53/164 (32%), Positives = 86/164 (52%), Gaps = 27/164 (16%) Query: 269 RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALT 328 RDGK ++++ L++Y + L+R SE P+ PE++ G V + Sbjct: 344 RDGKALERF--------LQDYFDGNLKR--------YLKSE-PI----PESNDGPVKVVV 382 Query: 329 ENNFDDTI--AEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 386 NFD+ + I+FYAPWCGHCK L P ++EL +K + IA++D TA + Sbjct: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEK-LSKDPNIVIAKMDATA-ND 440 Query: 387 ICSKYSVRGYPTLLLFRGGKKVS--EHSGGRDLDSLHRFVLSQA 428 + S Y VRG+PT+ KK++ ++ GGR+L ++ +A Sbjct: 441 VPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREA 484 Score = 70.9 bits (172), Expect = 2e-12 Identities = 36/98 (36%), Positives = 59/98 (60%), Gaps = 7/98 (7%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 + F+APWCGHC+ L+P + +LG+K + +D + +AK+D TA +DV S VRG+PT+ Sbjct: 399 IEFYAPWCGHCKNLEPKYKELGEKLS--KDPNIVIAKMDATA-NDVPSPYEVRGFPTI-Y 454 Query: 142 FKPGQEAV---KYQGPRDFQTLENWMLQTLNEEPVTPE 176 F P + + KY+G R+ +++ + PV E Sbjct: 455 FSPANKKLNPKKYEGGRELSDFISYLQREATNPPVIQE 492 Score = 65.9 bits (159), Expect = 7e-11 Identities = 35/102 (34%), Positives = 60/102 (58%), Gaps = 5/102 (4%) Query: 196 ASNFE--LHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYEL 253 A NF+ ++ D I+F+APWCGHCK L P +++L L + I K+D T + ++ Sbjct: 383 AENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN-DV 441 Query: 254 CSGNQVRGYPTLLWFRDGKKVD--QYKGKRDLESLREYVESQ 293 S +VRG+PT+ + KK++ +Y+G R+L Y++ + Sbjct: 442 PSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQRE 483 >gi|20070125 prolyl 4-hydroxylase, beta subunit precursor [Homo sapiens] Length = 508 Score = 86.3 bits (212), Expect = 5e-17 Identities = 42/114 (36%), Positives = 69/114 (60%), Gaps = 3/114 (2%) Query: 310 APVLAAEPEADKGTVLALTENNFDDTIA-EGITFIKFYAPWCGHCKTLAPTWEELSKKEF 368 A ++ A+ ++ VL L ++NF + +A ++FYAPWCGHCK LAP + + + K Sbjct: 12 AALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLK 71 Query: 369 PGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVS--EHSGGRDLDSL 420 + +++A+VD T E ++ +Y VRGYPT+ FR G S E++ GR+ D + Sbjct: 72 AEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDI 125 Score = 76.3 bits (186), Expect = 5e-14 Identities = 51/149 (34%), Positives = 78/149 (52%), Gaps = 14/149 (9%) Query: 184 APELKQGLYELSASNFELHVAQGDHF-IKFFAPWCGHCKALAPTWEQLA--LGLEHSETV 240 APE + + L SNF +A + ++F+APWCGHCKALAP + + A L E SE + Sbjct: 19 APEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSE-I 77 Query: 241 KIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVD--QYKGKRDLESLREYVESQLQRTE 298 ++ KVD T+ +L VRGYPT+ +FR+G +Y R+ + + +++ + Sbjct: 78 RLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKR----- 132 Query: 299 TGATETVTPSEAPVLAAEPEADKGTVLAL 327 TG T P A AAE + V + Sbjct: 133 TGPAATTLPDGA---AAESLVESSEVAVI 158 Score = 74.3 bits (181), Expect = 2e-13 Identities = 38/92 (41%), Positives = 53/92 (57%), Gaps = 6/92 (6%) Query: 78 AAH---FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVR 134 AAH V F+APWCGHC+ L P + K + E +++ +AKVD T SD+ GVR Sbjct: 39 AAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKA-EGSEIRLAKVDATEESDLAQQYGVR 97 Query: 135 GYPTLKLFKPGQEA--VKYQGPRDFQTLENWM 164 GYPT+K F+ G A +Y R+ + NW+ Sbjct: 98 GYPTIKFFRNGDTASPKEYTAGREADDIVNWL 129 Score = 72.0 bits (175), Expect = 1e-12 Identities = 42/115 (36%), Positives = 61/115 (53%), Gaps = 7/115 (6%) Query: 320 DKGTVLALTENNFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIA 377 DK V L NF+D + F++FYAPWCGHCK LAP W++L + + + IA Sbjct: 365 DKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLG-ETYKDHENIVIA 423 Query: 378 EVDCTAERNICSKYSVRGYPTLLLF--RGGKKVSEHSGGRDLDSLHRFVLSQAKD 430 ++D TA N V +PTL F + V +++G R LD +F+ S +D Sbjct: 424 KMDSTA--NEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQD 476 Score = 68.2 bits (165), Expect = 1e-11 Identities = 40/110 (36%), Positives = 61/110 (55%), Gaps = 8/110 (7%) Query: 188 KQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGK 244 KQ + L NFE VA + F++F+APWCGHCK LAP W++L + E + I K Sbjct: 366 KQPVKVLVGKNFE-DVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAK 424 Query: 245 VDCTQHYELCSGNQVRGYPTLLWF--RDGKKVDQYKGKRDLESLREYVES 292 +D T + +V +PTL +F + V Y G+R L+ ++++ES Sbjct: 425 MDSTANE--VEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLES 472 Score = 65.5 bits (158), Expect = 9e-11 Identities = 32/86 (37%), Positives = 48/86 (55%), Gaps = 6/86 (6%) Query: 81 FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLK 140 FV F+APWCGHC++L P W+ LG+ Y E+ + +AK+D TA+ A V +PTLK Sbjct: 389 FVEFYAPWCGHCKQLAPIWDKLGETYKDHEN--IVIAKMDSTANE--VEAVKVHSFPTLK 444 Query: 141 LFKPGQE--AVKYQGPRDFQTLENWM 164 F + + Y G R + ++ Sbjct: 445 FFPASADRTVIDYNGERTLDGFKKFL 470 >gi|38505222 thioredoxin domain containing 10 [Homo sapiens] Length = 454 Score = 82.4 bits (202), Expect = 7e-16 Identities = 38/74 (51%), Positives = 53/74 (71%), Gaps = 2/74 (2%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V F+APWCGHC++L+P WN++G + S+ + V V K+D T++S + S GVRGYPT+KL Sbjct: 46 VDFYAPWCGHCKKLEPIWNEVGLEMKSI-GSPVKVGKMDATSYSSIASEFGVRGYPTIKL 104 Query: 142 FKPGQEAVKYQGPR 155 K G A Y+GPR Sbjct: 105 LK-GDLAYNYRGPR 117 Score = 73.6 bits (179), Expect = 3e-13 Identities = 41/114 (35%), Positives = 62/114 (54%), Gaps = 2/114 (1%) Query: 310 APVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFP 369 A V+ + KG V L E+ F + + I + FYAPWCGHCK L P W E+ + Sbjct: 14 ATVVVLDMVVCKGFVEDLDES-FKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKS 72 Query: 370 GLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRF 423 + VK+ ++D T+ +I S++ VRGYPT+ L +G + + G R D + F Sbjct: 73 IGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYN-YRGPRTKDDIIEF 125 Score = 67.8 bits (164), Expect = 2e-11 Identities = 31/81 (38%), Positives = 47/81 (58%), Gaps = 2/81 (2%) Query: 210 IKFFAPWCGHCKALAPTWEQLALGLEH-SETVKIGKVDCTQHYELCSGNQVRGYPTLLWF 268 + F+APWCGHCK L P W ++ L ++ VK+GK+D T + + S VRGYPT+ Sbjct: 46 VDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLL 105 Query: 269 RDGKKVDQYKGKRDLESLREY 289 + G Y+G R + + E+ Sbjct: 106 K-GDLAYNYRGPRTKDDIIEF 125 >gi|94966757 protein disulfide isomerase A2 [Homo sapiens] Length = 525 Score = 79.7 bits (195), Expect = 5e-15 Identities = 44/112 (39%), Positives = 64/112 (57%), Gaps = 7/112 (6%) Query: 317 PEADKGTVLALTENNFDDTIAEGI--TFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGV 374 P+ D+ V L NF+ + F+KFYAPWC HCK +AP WE L++K + + Sbjct: 383 PDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEK-YQDHEDI 441 Query: 375 KIAEVDCTAERNICSKYSVRGYPTLLLFRG--GKKVSEHSGGRDLDSLHRFV 424 IAE+D TA N ++V G+PTL F G+KV E+ RDL++ +F+ Sbjct: 442 IIAELDATA--NELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFL 491 Score = 79.3 bits (194), Expect = 6e-15 Identities = 42/112 (37%), Positives = 62/112 (55%), Gaps = 15/112 (13%) Query: 81 FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLK 140 FV F+APWC HC+ + P W L +KY ED + +A++D TA+ A V G+PTLK Sbjct: 410 FVKFYAPWCTHCKEMAPAWEALAEKYQDHED--IIIAELDATANE--LDAFAVHGFPTLK 465 Query: 141 LFK--PGQEAVKYQGPRDFQTLENWM-------LQTLNEEPVTPEPEVEPPS 183 F PG++ ++Y+ RD +T ++ + EEP P P EPP+ Sbjct: 466 YFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAAPFP--EPPA 515 Score = 75.9 bits (185), Expect = 7e-14 Identities = 46/123 (37%), Positives = 66/123 (53%), Gaps = 11/123 (8%) Query: 209 FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWF 268 F+KF+APWC HCK +AP WE LA + E + I ++D T + EL V G+PTL +F Sbjct: 410 FVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATAN-EL-DAFAVHGFPTLKYF 467 Query: 269 --RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLA 326 G+KV +YK RDLE+ +++++ G T P E P A PE + + Sbjct: 468 PAGPGRKVIEYKSTRDLETFSKFLDN------GGVLPTEEPPEEPA-APFPEPPANSTMG 520 Query: 327 LTE 329 E Sbjct: 521 SKE 523 Score = 74.7 bits (182), Expect = 2e-13 Identities = 55/165 (33%), Positives = 78/165 (47%), Gaps = 13/165 (7%) Query: 18 LTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAAD--GEDGQDPHSKHLYTADMFTHGI 75 L LLLLLL WG ++ A + ++ PP + EDG S+H + H Sbjct: 6 LPVLLLLLLR--ASCPWGQ--EQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREH-- 59 Query: 76 QSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRG 135 A V F+APWCGHCQ L P ++ + E V +AKVD A ++ GV Sbjct: 60 --PALLVEFYAPWCGHCQALAPEYSKAA-AVLAAESMVVTLAKVDGPAQRELAEEFGVTE 116 Query: 136 YPTLKLFKPGQEA--VKYQGPRDFQTLENWMLQTLNEEPVTPEPE 178 YPTLK F+ G +Y GPRD + + W+ + + + E E Sbjct: 117 YPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDE 161 Score = 72.4 bits (176), Expect = 7e-13 Identities = 57/182 (31%), Positives = 86/182 (47%), Gaps = 18/182 (9%) Query: 170 EEPVTPEPEVEPPSAPELKQ-GLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAP 225 +E P EPP K+ G+ LS L +A +H ++F+APWCGHC+ALAP Sbjct: 22 QEQGARSPSEEPPEEEIPKEDGILVLSRHT--LGLALREHPALLVEFYAPWCGHCQALAP 79 Query: 226 TWEQLALGL-EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKV--DQYKGKRD 282 + + A L S V + KVD EL V YPTL +FR+G + ++Y G RD Sbjct: 80 EYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRD 139 Query: 283 LESLREYVE-----SQLQRTETGATETVTPSEAPVLAA----EPEADKGTVLALTENNFD 333 E + E++ S ++ + A + + V+ + D T LAL ++ D Sbjct: 140 AEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALD 199 Query: 334 DT 335 T Sbjct: 200 MT 201 Score = 69.3 bits (168), Expect = 6e-12 Identities = 39/118 (33%), Positives = 62/118 (52%), Gaps = 5/118 (4%) Query: 306 TPSEAPVLAAEPEADKGTVLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELS 364 +PSE P P+ D +L L+ + + E ++FYAPWCGHC+ LAP + + + Sbjct: 28 SPSEEPPEEEIPKEDG--ILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAA 85 Query: 365 KKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKV--SEHSGGRDLDSL 420 V +A+VD A+R + ++ V YPTL FR G + E++G RD + + Sbjct: 86 AVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGI 143 >gi|52487191 thioredoxin domain containing 4 (endoplasmic reticulum) [Homo sapiens] Length = 406 Score = 67.8 bits (164), Expect = 2e-11 Identities = 38/114 (33%), Positives = 57/114 (50%), Gaps = 5/114 (4%) Query: 324 VLALTENNFDDTIAEG-ITFIKFYAPWCGHCKTLAPTWEELS---KKEFPGLAGVKIAEV 379 + +L N D+ + + + FYA WC + L P +EE S K+EFP V A V Sbjct: 31 ITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARV 90 Query: 380 DCTAERNICSKYSVRGYPTLLLFRGGKKVS-EHSGGRDLDSLHRFVLSQAKDEL 432 DC +I +Y + YPTL LFR G + E+ G R + +L ++ Q D + Sbjct: 91 DCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPI 144 Score = 57.8 bits (138), Expect = 2e-08 Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 3/88 (3%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGD--KYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTL 139 V F+A WC Q L P + + D K + +V A+VDC HSD+ + YPTL Sbjct: 51 VNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTL 110 Query: 140 KLFKPGQEAVK-YQGPRDFQTLENWMLQ 166 KLF+ G + Y+G R + L +++ Q Sbjct: 111 KLFRNGMMMKREYRGQRSVKALADYIRQ 138 Score = 55.1 bits (131), Expect = 1e-07 Identities = 26/89 (29%), Positives = 50/89 (56%), Gaps = 5/89 (5%) Query: 210 IKFFAPWCGHCKALAPTWEQLALGLE----HSETVKIGKVDCTQHYELCSGNQVRGYPTL 265 + F+A WC + L P +E+ + ++ + V +VDC QH ++ ++ YPTL Sbjct: 51 VNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTL 110 Query: 266 LWFRDGKKVD-QYKGKRDLESLREYVESQ 293 FR+G + +Y+G+R +++L +Y+ Q Sbjct: 111 KLFRNGMMMKREYRGQRSVKALADYIRQQ 139 >gi|51873067 quiescin Q6 sulfhydryl oxidase 1 isoform b [Homo sapiens] Length = 604 Score = 63.9 bits (154), Expect = 3e-10 Identities = 69/252 (27%), Positives = 96/252 (38%), Gaps = 38/252 (15%) Query: 78 AAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCT--AHSDVCSAQGVRG 135 +A V FFA WCGHC PTW L + + A +Y+A +DC +S VC + G Sbjct: 59 SAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPA-LYLAALDCAEETNSAVCRDFNIPG 117 Query: 136 YPTLKLFKP----GQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGL 191 +PT++ FK G AV D QTL ++ L T P PP P + + Sbjct: 118 FPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPAC-PPLEPAKLEEI 176 Query: 192 YELSASNFELHVA-----QGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVD 246 A N E ++A G + + A K +A + L E + K G D Sbjct: 177 DGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVA---VRRVLNTEANVVRKFGVTD 233 Query: 247 CTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQR----TETGAT 302 Y L V P L+ R + + LQR T A Sbjct: 234 FPSCYLLFRNGSVSRVPVLM------------------ESRSFYTAYLQRLSGLTREAAQ 275 Query: 303 ETVTPSEAPVLA 314 TV P+ A +A Sbjct: 276 TTVAPTTANKIA 287 Score = 57.4 bits (137), Expect = 2e-08 Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 2/67 (2%) Query: 343 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN--ICSKYSVRGYPTLL 400 ++F+A WCGHC APTW+ L++ + +A +DC E N +C +++ G+PT+ Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122 Query: 401 LFRGGKK 407 F+ K Sbjct: 123 FFKAFTK 129 Score = 53.1 bits (126), Expect = 5e-07 Identities = 53/204 (25%), Positives = 91/204 (44%), Gaps = 30/204 (14%) Query: 210 IKFFAPWCGHCKALAPTWEQLALGLE-HSETVKIGKVDCTQ--HYELCSGNQVRGYPTLL 266 ++FFA WCGHC A APTW+ LA ++ + + +DC + + +C + G+PT+ Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122 Query: 267 WF----RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKG 322 +F ++G D+++LRE + L+ +T P+ P+ A+ E G Sbjct: 123 FFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHH----DTWPPACPPLEPAKLEEIDG 178 Query: 323 TVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCT 382 E +G +++ G L +LS+ + GV + V Sbjct: 179 FFARNNEEYLALIFEKGGSYL-------GREVAL-----DLSQHK-----GVAVRRV-LN 220 Query: 383 AERNICSKYSVRGYPT-LLLFRGG 405 E N+ K+ V +P+ LLFR G Sbjct: 221 TEANVVRKFGVTDFPSCYLLFRNG 244 >gi|13325075 quiescin Q6 sulfhydryl oxidase 1 isoform a [Homo sapiens] Length = 747 Score = 63.9 bits (154), Expect = 3e-10 Identities = 69/252 (27%), Positives = 96/252 (38%), Gaps = 38/252 (15%) Query: 78 AAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCT--AHSDVCSAQGVRG 135 +A V FFA WCGHC PTW L + + A +Y+A +DC +S VC + G Sbjct: 59 SAWAVEFFASWCGHCIAFAPTWKALAEDVKAWRPA-LYLAALDCAEETNSAVCRDFNIPG 117 Query: 136 YPTLKLFKP----GQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGL 191 +PT++ FK G AV D QTL ++ L T P PP P + + Sbjct: 118 FPTVRFFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHHDTWPPAC-PPLEPAKLEEI 176 Query: 192 YELSASNFELHVA-----QGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVD 246 A N E ++A G + + A K +A + L E + K G D Sbjct: 177 DGFFARNNEEYLALIFEKGGSYLGREVALDLSQHKGVA---VRRVLNTEANVVRKFGVTD 233 Query: 247 CTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQR----TETGAT 302 Y L V P L+ R + + LQR T A Sbjct: 234 FPSCYLLFRNGSVSRVPVLM------------------ESRSFYTAYLQRLSGLTREAAQ 275 Query: 303 ETVTPSEAPVLA 314 TV P+ A +A Sbjct: 276 TTVAPTTANKIA 287 Score = 57.4 bits (137), Expect = 2e-08 Identities = 23/67 (34%), Positives = 39/67 (58%), Gaps = 2/67 (2%) Query: 343 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN--ICSKYSVRGYPTLL 400 ++F+A WCGHC APTW+ L++ + +A +DC E N +C +++ G+PT+ Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122 Query: 401 LFRGGKK 407 F+ K Sbjct: 123 FFKAFTK 129 Score = 53.1 bits (126), Expect = 5e-07 Identities = 53/204 (25%), Positives = 91/204 (44%), Gaps = 30/204 (14%) Query: 210 IKFFAPWCGHCKALAPTWEQLALGLE-HSETVKIGKVDCTQ--HYELCSGNQVRGYPTLL 266 ++FFA WCGHC A APTW+ LA ++ + + +DC + + +C + G+PT+ Sbjct: 63 VEFFASWCGHCIAFAPTWKALAEDVKAWRPALYLAALDCAEETNSAVCRDFNIPGFPTVR 122 Query: 267 WF----RDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKG 322 +F ++G D+++LRE + L+ +T P+ P+ A+ E G Sbjct: 123 FFKAFTKNGSGAVFPVAGADVQTLRERLIDALESHH----DTWPPACPPLEPAKLEEIDG 178 Query: 323 TVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCT 382 E +G +++ G L +LS+ + GV + V Sbjct: 179 FFARNNEEYLALIFEKGGSYL-------GREVAL-----DLSQHK-----GVAVRRV-LN 220 Query: 383 AERNICSKYSVRGYPT-LLLFRGG 405 E N+ K+ V +P+ LLFR G Sbjct: 221 TEANVVRKFGVTDFPSCYLLFRNG 244 >gi|145580631 quiescin Q6 sulfhydryl oxidase 2 [Homo sapiens] Length = 698 Score = 60.8 bits (146), Expect = 2e-09 Identities = 29/90 (32%), Positives = 44/90 (48%), Gaps = 8/90 (8%) Query: 320 DKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEV 379 D G+V T N+ ++FY+ WCGHC APTW L+ + +++A + Sbjct: 67 DSGSVRGATANS------SAAWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAAL 120 Query: 380 DCTAERN--ICSKYSVRGYPTLLLFRGGKK 407 DC E+N +C Y + YPT F+ K Sbjct: 121 DCMEEKNQAVCHDYDIHFYPTFRYFKAFTK 150 Score = 56.2 bits (134), Expect = 6e-08 Identities = 35/136 (25%), Positives = 66/136 (48%), Gaps = 15/136 (11%) Query: 210 IKFFAPWCGHCKALAPTWEQLALGL-EHSETVKIGKVDCTQ--HYELCSGNQVRGYPTLL 266 ++F++ WCGHC APTW LA + + + +++ +DC + + +C + YPT Sbjct: 84 VQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFR 143 Query: 267 WFRDGKKV----DQYKG-KRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADK 321 +F+ K + +KG R+L ++R+ + LQ G+ P P+ ++ Sbjct: 144 YFKAFTKEFTTGENFKGPDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSD----- 198 Query: 322 GTVLALTENNFDDTIA 337 VL+L +N +A Sbjct: 199 --VLSLLDNRGSHYVA 212 Score = 55.5 bits (132), Expect = 9e-08 Identities = 50/162 (30%), Positives = 66/162 (40%), Gaps = 28/162 (17%) Query: 43 AAAADGPPAAD-------GEDGQ---DPHSKHLYTADMFTHGIQSAAHFVMFFAPWCGHC 92 AAAA GP A GED D S TA+ SAA V F++ WCGHC Sbjct: 41 AAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATAN------SSAAWLVQFYSSWCGHC 94 Query: 93 QRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSD--VCSAQGVRGYPTLKLFKPGQE--- 147 PTW L A + VA +DC + VC + YPT + FK + Sbjct: 95 IGYAPTWRALAGDVRDWASA-IRVAALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFT 153 Query: 148 -AVKYQGP-RDFQTLENWMLQTLNEEPVTPEPEVEPPSAPEL 187 ++GP R+ +T+ M+ L PP+ P L Sbjct: 154 TGENFKGPDRELRTVRQTMIDFLQNH----TEGSRPPACPRL 191 >gi|21361403 thioredoxin 2 precursor [Homo sapiens] Length = 166 Score = 54.3 bits (129), Expect = 2e-07 Identities = 39/129 (30%), Positives = 59/129 (45%), Gaps = 18/129 (13%) Query: 304 TVTPSEAPVLAAEPEADKGTVLALTENN------FDDTIAEGIT--FIKFYAPWCGHCKT 355 TVTP+ A + T ++LT N F D + T + F+A WCG CK Sbjct: 43 TVTPNPARTIYT-------TRISLTTFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKI 95 Query: 356 LAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGR 415 L P E++ K+ V +A+VD ++ +Y V PT+L + G V + G + Sbjct: 96 LGPRLEKMVAKQH---GKVVMAKVDIDDHTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIK 152 Query: 416 DLDSLHRFV 424 D D L F+ Sbjct: 153 DEDQLEAFL 161 Score = 53.5 bits (127), Expect = 4e-07 Identities = 27/82 (32%), Positives = 46/82 (56%), Gaps = 2/82 (2%) Query: 210 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFR 269 + F A WCG CK L P E++ + +H + V + KVD H +L +V PT+L + Sbjct: 83 VDFHAQWCGPCKILGPRLEKM-VAKQHGKVV-MAKVDIDDHTDLAIEYEVSAVPTVLAMK 140 Query: 270 DGKKVDQYKGKRDLESLREYVE 291 +G VD++ G +D + L +++ Sbjct: 141 NGDVVDKFVGIKDEDQLEAFLK 162 Score = 46.2 bits (108), Expect = 6e-05 Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 4/83 (4%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V F A WCG C+ L P +K + + KV +AKVD H+D+ V PT+ Sbjct: 83 VDFHAQWCGPCKILGPRL----EKMVAKQHGKVVMAKVDIDDHTDLAIEYEVSAVPTVLA 138 Query: 142 FKPGQEAVKYQGPRDFQTLENWM 164 K G K+ G +D LE ++ Sbjct: 139 MKNGDVVDKFVGIKDEDQLEAFL 161 >gi|28372543 protein disulfide isomerase-like, testis expressed [Homo sapiens] Length = 584 Score = 54.3 bits (129), Expect = 2e-07 Identities = 39/135 (28%), Positives = 60/135 (44%), Gaps = 19/135 (14%) Query: 81 FVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLK 140 FVMF+APW C+ L P +LG KY + + + +AK+D TA+ + YP + Sbjct: 409 FVMFYAPWSKKCKMLFPLLEELGRKYQN--HSTIIIAKIDVTAND--IQLMYLDRYPFFR 464 Query: 141 LFKPG-QEAVKYQGPRDFQTL--------------ENWMLQTLNEEPVTPEPEVEPPSAP 185 LF G Q+AV Y+G + E+ +L E + E E P Sbjct: 465 LFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDEDELLSVEQNEVIEEEVLAEEKEVP 524 Query: 186 ELKQGLYELSASNFE 200 +++GL E + E Sbjct: 525 MMRKGLPEQQSPELE 539 Score = 53.5 bits (127), Expect = 4e-07 Identities = 49/196 (25%), Positives = 93/196 (47%), Gaps = 14/196 (7%) Query: 137 PTLKLFKPGQEAVKYQGPRD---FQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLY- 192 P++++ +A +Y+ P D +++L+ + L++ + E P + QGL Sbjct: 334 PSVQILNLSSDA-RYKMPSDDITYESLKKFGRSFLSKNATKHQSSEEIPKYWD--QGLVK 390 Query: 193 ELSASNFELHV--AQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQH 250 +L NF + V + D F+ F+APW CK L P E+L ++ T+ I K+D T + Sbjct: 391 QLVGKNFNVVVFDKEKDVFVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAKIDVTAN 450 Query: 251 -YELCSGNQVRGYPTLLWFRDG-KKVDQYKGKRDLESLREYVESQLQRTETGATETVTPS 308 +L + YP F G ++ YKG+ L+ +++ES ++ E ++ Sbjct: 451 DIQLM---YLDRYPFFRLFPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDEDELLSVE 507 Query: 309 EAPVLAAEPEADKGTV 324 + V+ E A++ V Sbjct: 508 QNEVIEEEVLAEEKEV 523 Score = 50.8 bits (120), Expect = 2e-06 Identities = 49/155 (31%), Positives = 73/155 (47%), Gaps = 18/155 (11%) Query: 284 ESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTI--AEGIT 341 ESL+++ S L + AT+ + E P D+G V L NF+ + E Sbjct: 357 ESLKKFGRSFLSKN---ATKHQSSEEIPKYW-----DQGLVKQLVGKNFNVVVFDKEKDV 408 Query: 342 FIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLL 401 F+ FYAPW CK L P EEL +K + + + IA++D TA +I Y R YP L Sbjct: 409 FVMFYAPWSKKCKMLFPLLEELGRK-YQNHSTIIIAKIDVTA-NDIQLMYLDR-YPFFRL 465 Query: 402 FRGGKKVS-----EHSGGRDLDSLHRFVLSQAKDE 431 F G + + EH+ D L + ++ +DE Sbjct: 466 FPSGSQQAVLYKGEHTLKGFSDFLESHIKTKIEDE 500 >gi|151101292 thioredoxin domain containing 1 [Homo sapiens] Length = 280 Score = 53.1 bits (126), Expect = 5e-07 Identities = 30/89 (33%), Positives = 45/89 (50%), Gaps = 2/89 (2%) Query: 205 QGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPT 264 +GD I+F+APWC C+ L P WE A E E V I KVD T+ L + PT Sbjct: 44 EGDWMIEFYAPWCPACQNLQPEWESFAEWGEDLE-VNIAKVDVTEQPGLSGRFIITALPT 102 Query: 265 LLWFRDGKKVDQYKGKRDLESLREYVESQ 293 + +DG + +Y+G R + ++ + Sbjct: 103 IYHCKDG-EFRRYQGPRTKKDFINFISDK 130 Score = 53.1 bits (126), Expect = 5e-07 Identities = 30/83 (36%), Positives = 42/83 (50%), Gaps = 4/83 (4%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 + F+APWC CQ LQP W + ED +V +AKVD T + + PT+ Sbjct: 49 IEFYAPWCPACQNLQPEWESFAE---WGEDLEVNIAKVDVTEQPGLSGRFIITALPTIYH 105 Query: 142 FKPGQEAVKYQGPRDFQTLENWM 164 K G E +YQGPR + N++ Sbjct: 106 CKDG-EFRRYQGPRTKKDFINFI 127 Score = 52.8 bits (125), Expect = 6e-07 Identities = 27/86 (31%), Positives = 46/86 (53%), Gaps = 3/86 (3%) Query: 321 KGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVD 380 + V +T+ N+ + + EG I+FYAPWC C+ L P WE + E+ V IA+VD Sbjct: 28 RSNVRVITDENWRELL-EGDWMIEFYAPWCPACQNLQPEWESFA--EWGEDLEVNIAKVD 84 Query: 381 CTAERNICSKYSVRGYPTLLLFRGGK 406 T + + ++ + PT+ + G+ Sbjct: 85 VTEQPGLSGRFIITALPTIYHCKDGE 110 >gi|40254947 thioredoxin-related transmembrane protein 4 [Homo sapiens] Length = 349 Score = 53.1 bits (126), Expect = 5e-07 Identities = 39/125 (31%), Positives = 58/125 (46%), Gaps = 8/125 (6%) Query: 175 PEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGL 234 PE PP ++ ++ASN+ L V +G+ +KF+APWC C+ WE A Sbjct: 27 PEEAALPPEQSRVQP----MTASNWTL-VMEGEWMLKFYAPWCPSCQQTDSEWEAFAKNG 81 Query: 235 EHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYV-ESQ 293 E + + +GKVD Q L V P +DG +Y+G E L+ Y+ E + Sbjct: 82 EILQ-ISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDG-IFRRYRGPGIFEDLQNYILEKK 139 Query: 294 LQRTE 298 Q E Sbjct: 140 WQSVE 144 Score = 45.4 bits (106), Expect = 1e-04 Identities = 48/183 (26%), Positives = 77/183 (42%), Gaps = 22/183 (12%) Query: 31 GGRWGARAQEAAAA--AADGPPAADGEDGQDPHSKHLY--TADMFTHGIQSAAHFVMFFA 86 GGR G + AA AA A E P + TA +T + + F+A Sbjct: 3 GGRCGPQLTALLAAWIAAVAATAGPEEAALPPEQSRVQPMTASNWTL-VMEGEWMLKFYA 61 Query: 87 PWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRG---YPTLKLFK 143 PWC CQ+ W + E ++ V KV DV G+ G TL F Sbjct: 62 PWCPSCQQTDSEWEAFA---KNGEILQISVGKV------DVIQEPGLSGRFFVTTLPAFF 112 Query: 144 PGQEAV--KYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELK--QGLYELSASNF 199 ++ + +Y+GP F+ L+N++L+ + V P + P++ + GL+ +S + Sbjct: 113 HAKDGIFRRYRGPGIFEDLQNYILEK-KWQSVEPLTGWKSPASLTMSGMAGLFSISGKIW 171 Query: 200 ELH 202 LH Sbjct: 172 HLH 174 Score = 43.5 bits (101), Expect = 4e-04 Identities = 29/102 (28%), Positives = 45/102 (44%), Gaps = 8/102 (7%) Query: 304 TVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEEL 363 T P EA A PE + V +T +N+ + EG +KFYAPWC C+ WE Sbjct: 24 TAGPEEA---ALPPEQSR--VQPMTASNWT-LVMEGEWMLKFYAPWCPSCQQTDSEWEAF 77 Query: 364 SKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGG 405 +K + + + +VD E + ++ V P + G Sbjct: 78 AKN--GEILQISVGKVDVIQEPGLSGRFFVTTLPAFFHAKDG 117 >gi|50592994 thioredoxin [Homo sapiens] Length = 105 Score = 51.2 bits (121), Expect = 2e-06 Identities = 27/80 (33%), Positives = 41/80 (51%), Gaps = 4/80 (5%) Query: 334 DTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSV 393 D + + + F A WCG CK + P + LS+K + V EVD +++ S+ V Sbjct: 16 DAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEK----YSNVIFLEVDVDDCQDVASECEV 71 Query: 394 RGYPTLLLFRGGKKVSEHSG 413 + PT F+ G+KV E SG Sbjct: 72 KCMPTFQFFKKGQKVGEFSG 91 Score = 47.8 bits (112), Expect = 2e-05 Identities = 25/72 (34%), Positives = 39/72 (54%), Gaps = 5/72 (6%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V F A WCG C+ ++P ++ L +KY++ V +VD DV S V+ PT + Sbjct: 25 VDFSATWCGPCKMIKPFFHSLSEKYSN-----VIFLEVDVDDCQDVASECEVKCMPTFQF 79 Query: 142 FKPGQEAVKYQG 153 FK GQ+ ++ G Sbjct: 80 FKKGQKVGEFSG 91 Score = 43.1 bits (100), Expect = 5e-04 Identities = 28/86 (32%), Positives = 43/86 (50%), Gaps = 7/86 (8%) Query: 204 AQGDHFI--KFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRG 261 A GD + F A WCG CK + P + L+ E V +VD ++ S +V+ Sbjct: 17 AAGDKLVVVDFSATWCGPCKMIKPFFHSLS---EKYSNVIFLEVDVDDCQDVASECEVKC 73 Query: 262 YPTLLWFRDGKKVDQYKG--KRDLES 285 PT +F+ G+KV ++ G K LE+ Sbjct: 74 MPTFQFFKKGQKVGEFSGANKEKLEA 99 >gi|4759274 thioredoxin-like 1 [Homo sapiens] Length = 289 Score = 47.8 bits (112), Expect = 2e-05 Identities = 44/177 (24%), Positives = 79/177 (44%), Gaps = 26/177 (14%) Query: 171 EPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQL 230 +PV +P+ +P ELS + L V +KF CG C +AP + + Sbjct: 5 KPVGSDPDFQP-----------ELSGAGSRLAV------VKFTMRGCGPCLRIAPAFSSM 47 Query: 231 ALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYV 290 + ++ + V + +VD Q + N + PT L+FR+ ++DQY+G D L E + Sbjct: 48 SN--KYPQAVFL-EVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQG-ADAVGLEEKI 103 Query: 291 ESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENN---FDDTIAEGITFIK 344 + L+ +T P + P +K L E++ FD+ + + TF++ Sbjct: 104 KQHLENDPGSNEDTDIPK--GYMDLMPFINKAGCECLNESDEHGFDNCLRKDTTFLE 158 Score = 34.7 bits (78), Expect = 0.17 Identities = 30/103 (29%), Positives = 44/103 (42%), Gaps = 6/103 (5%) Query: 74 GIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGV 133 G S V F CG C R+ P ++ + +KY +V V + TA ++ SA Sbjct: 19 GAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISAT-- 76 Query: 134 RGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPE 176 PT F+ +YQG D LE + Q L +P + E Sbjct: 77 ---PTFLFFRNKVRIDQYQG-ADAVGLEEKIKQHLENDPGSNE 115 Score = 33.9 bits (76), Expect = 0.29 Identities = 19/74 (25%), Positives = 33/74 (44%), Gaps = 4/74 (5%) Query: 340 ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTL 399 + +KF CG C +AP + +S K +P EVD + + ++ PT Sbjct: 24 LAVVKFTMRGCGPCLRIAPAFSSMSNK-YPQAV---FLEVDVHQCQGTAATNNISATPTF 79 Query: 400 LLFRGGKKVSEHSG 413 L FR ++ ++ G Sbjct: 80 LFFRNKVRIDQYQG 93 >gi|237648961 thioredoxin domain containing 16 isoform 2 [Homo sapiens] Length = 820 Score = 46.6 bits (109), Expect = 4e-05 Identities = 22/87 (25%), Positives = 43/87 (49%), Gaps = 2/87 (2%) Query: 67 TADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSD 126 T + F + ++ V+F+A W ++ D+ K + + + +++C SD Sbjct: 392 TEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGT--STMLLTRINCADWSD 449 Query: 127 VCSAQGVRGYPTLKLFKPGQEAVKYQG 153 VC+ Q V +P +K++K G+ V Y G Sbjct: 450 VCTKQNVTEFPIIKMYKKGENPVSYAG 476 Score = 46.2 bits (108), Expect = 6e-05 Identities = 21/99 (21%), Positives = 47/99 (47%) Query: 193 ELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 252 EL+ F V D + F+A W A ++ +A+ L+ + T+ + +++C + Sbjct: 390 ELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSD 449 Query: 253 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVE 291 +C+ V +P + ++ G+ Y G E L ++++ Sbjct: 450 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQ 488 Score = 42.7 bits (99), Expect = 6e-04 Identities = 20/98 (20%), Positives = 49/98 (50%), Gaps = 1/98 (1%) Query: 327 LTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 386 LTE F+ T+ + + FYA W ++ +++ K G + + + ++C + Sbjct: 391 LTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVK-LKGTSTMLLTRINCADWSD 449 Query: 387 ICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFV 424 +C+K +V +P + +++ G+ ++G + L +F+ Sbjct: 450 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFI 487 >gi|237648959 thioredoxin domain containing 16 isoform 1 [Homo sapiens] Length = 825 Score = 46.6 bits (109), Expect = 4e-05 Identities = 22/87 (25%), Positives = 43/87 (49%), Gaps = 2/87 (2%) Query: 67 TADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSD 126 T + F + ++ V+F+A W ++ D+ K + + + +++C SD Sbjct: 397 TEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGT--STMLLTRINCADWSD 454 Query: 127 VCSAQGVRGYPTLKLFKPGQEAVKYQG 153 VC+ Q V +P +K++K G+ V Y G Sbjct: 455 VCTKQNVTEFPIIKMYKKGENPVSYAG 481 Score = 46.2 bits (108), Expect = 6e-05 Identities = 21/99 (21%), Positives = 47/99 (47%) Query: 193 ELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYE 252 EL+ F V D + F+A W A ++ +A+ L+ + T+ + +++C + Sbjct: 395 ELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVKLKGTSTMLLTRINCADWSD 454 Query: 253 LCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVE 291 +C+ V +P + ++ G+ Y G E L ++++ Sbjct: 455 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFIQ 493 Score = 42.7 bits (99), Expect = 6e-04 Identities = 20/98 (20%), Positives = 49/98 (50%), Gaps = 1/98 (1%) Query: 327 LTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERN 386 LTE F+ T+ + + FYA W ++ +++ K G + + + ++C + Sbjct: 396 LTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVK-LKGTSTMLLTRINCADWSD 454 Query: 387 ICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFV 424 +C+K +V +P + +++ G+ ++G + L +F+ Sbjct: 455 VCTKQNVTEFPIIKMYKKGENPVSYAGMLGTEDLLKFI 492 >gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sapiens] Length = 486 Score = 46.6 bits (109), Expect = 4e-05 Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 15/121 (12%) Query: 303 ETVTPS-EAPVLAAE------PEADKGTVLALTENNFDDTIAEG---ITFIKFYAPWCGH 352 E TPS E +L E PE DK V+ L++ +F+ ++ E + + F A WCG Sbjct: 357 EEATPSKEGDILKPEEETMEFPEGDKVKVI-LSKEDFEASLKEAGERLVAVDFSATWCGP 415 Query: 353 CKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHS 412 C+T+ P + LS K V EVD + + ++ PT ++ +KV E Sbjct: 416 CRTIRPFFHALSVKH----EDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELC 471 Query: 413 G 413 G Sbjct: 472 G 472 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 8/116 (6%) Query: 176 EPEVEPPSAPELKQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLAL 232 +PE E PE + LS +FE + + + F A WCG C+ + P + AL Sbjct: 369 KPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH--AL 426 Query: 233 GLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKG--KRDLESL 286 ++H + V + +VD E+ + PT +++ +KVD+ G K LE++ Sbjct: 427 SVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAV 481 Score = 30.0 bits (66), Expect = 4.3 Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 5/62 (8%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V F A WCG C+ ++P ++ L K+ V +VD +V + PT + Sbjct: 406 VDFSATWCGPCRTIRPFFHALSVKHED-----VVFLEVDADNCEEVVRECAIMCVPTFQF 460 Query: 142 FK 143 +K Sbjct: 461 YK 462 >gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sapiens] Length = 553 Score = 46.6 bits (109), Expect = 4e-05 Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 15/121 (12%) Query: 303 ETVTPS-EAPVLAAE------PEADKGTVLALTENNFDDTIAEG---ITFIKFYAPWCGH 352 E TPS E +L E PE DK V+ L++ +F+ ++ E + + F A WCG Sbjct: 424 EEATPSKEGDILKPEEETMEFPEGDKVKVI-LSKEDFEASLKEAGERLVAVDFSATWCGP 482 Query: 353 CKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHS 412 C+T+ P + LS K V EVD + + ++ PT ++ +KV E Sbjct: 483 CRTIRPFFHALSVKH----EDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELC 538 Query: 413 G 413 G Sbjct: 539 G 539 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 8/116 (6%) Query: 176 EPEVEPPSAPELKQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLAL 232 +PE E PE + LS +FE + + + F A WCG C+ + P + AL Sbjct: 436 KPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH--AL 493 Query: 233 GLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKG--KRDLESL 286 ++H + V + +VD E+ + PT +++ +KVD+ G K LE++ Sbjct: 494 SVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAV 548 Score = 30.0 bits (66), Expect = 4.3 Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 5/62 (8%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V F A WCG C+ ++P ++ L K+ V +VD +V + PT + Sbjct: 473 VDFSATWCGPCRTIRPFFHALSVKHED-----VVFLEVDADNCEEVVRECAIMCVPTFQF 527 Query: 142 FK 143 +K Sbjct: 528 YK 529 >gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapiens] Length = 486 Score = 46.6 bits (109), Expect = 4e-05 Identities = 36/121 (29%), Positives = 56/121 (46%), Gaps = 15/121 (12%) Query: 303 ETVTPS-EAPVLAAE------PEADKGTVLALTENNFDDTIAEG---ITFIKFYAPWCGH 352 E TPS E +L E PE DK V+ L++ +F+ ++ E + + F A WCG Sbjct: 357 EEATPSKEGDILKPEEETMEFPEGDKVKVI-LSKEDFEASLKEAGERLVAVDFSATWCGP 415 Query: 353 CKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHS 412 C+T+ P + LS K V EVD + + ++ PT ++ +KV E Sbjct: 416 CRTIRPFFHALSVKH----EDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELC 471 Query: 413 G 413 G Sbjct: 472 G 472 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 8/116 (6%) Query: 176 EPEVEPPSAPELKQGLYELSASNFELHVAQGDH---FIKFFAPWCGHCKALAPTWEQLAL 232 +PE E PE + LS +FE + + + F A WCG C+ + P + AL Sbjct: 369 KPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFH--AL 426 Query: 233 GLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKG--KRDLESL 286 ++H + V + +VD E+ + PT +++ +KVD+ G K LE++ Sbjct: 427 SVKHEDVVFL-EVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAV 481 Score = 30.0 bits (66), Expect = 4.3 Identities = 17/62 (27%), Positives = 28/62 (45%), Gaps = 5/62 (8%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V F A WCG C+ ++P ++ L K+ V +VD +V + PT + Sbjct: 406 VDFSATWCGPCRTIRPFFHALSVKHED-----VVFLEVDADNCEEVVRECAIMCVPTFQF 460 Query: 142 FK 143 +K Sbjct: 461 YK 462 >gi|94421469 disulfide isomerase [Homo sapiens] Length = 360 Score = 45.4 bits (106), Expect = 1e-04 Identities = 36/151 (23%), Positives = 68/151 (45%), Gaps = 16/151 (10%) Query: 289 YVESQLQRTETGATETVTPSEA---PVLAAEPEADKGT------VLALTENNFDDTIAEG 339 Y E ++ ++ TE +E+ P + E G +L ++++ D G Sbjct: 148 YTEPEVAESDAAPTEDSNNTESLKSPKVNCEERNITGLENFTLKILNMSQDLMDFLNPNG 207 Query: 340 --ITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYP 397 T + FY PWC +LAP + L + FP L +D + ++ +++ P Sbjct: 208 SDCTLVLFYTPWCRFSASLAPHFNSL-PRAFPAL---HFLALDASQHSSLSTRFGTVAVP 263 Query: 398 TLLLFRGGKKVSE-HSGGRDLDSLHRFVLSQ 427 +LLF+G K ++ + R L++L F+ +Q Sbjct: 264 NILLFQGAKPMARFNHTDRTLETLKIFIFNQ 294 Score = 35.4 bits (80), Expect = 0.10 Identities = 22/106 (20%), Positives = 45/106 (42%), Gaps = 7/106 (6%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKL 141 V+F+ PWC L P +N L + ++ + +D + HS + + G P + L Sbjct: 213 VLFYTPWCRFSASLAPHFNSLPRAFPAL-----HFLALDASQHSSLSTRFGTVAVPNILL 267 Query: 142 FKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPEL 187 F+ + ++ +TLE + N+ + + V A ++ Sbjct: 268 FQGAKPMARFN--HTDRTLETLKIFIFNQTGIEAKKNVVVTQADQI 311 Score = 33.9 bits (76), Expect = 0.29 Identities = 26/109 (23%), Positives = 48/109 (44%), Gaps = 7/109 (6%) Query: 210 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFR 269 + F+ PWC +LAP + L + +D +QH L + P +L F+ Sbjct: 213 VLFYTPWCRFSASLAPHFNSLPRAF---PALHFLALDASQHSSLSTRFGTVAVPNILLFQ 269 Query: 270 DGKKVDQYK-GKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEP 317 K + ++ R LE+L+ ++ +Q T A + V ++A + P Sbjct: 270 GAKPMARFNHTDRTLETLKIFIFNQ---TGIEAKKNVVVTQADQIGPLP 315 >gi|221136993 thioredoxin domain containing 14 isoform 2 [Homo sapiens] Length = 258 Score = 43.1 bits (100), Expect = 5e-04 Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 8/71 (11%) Query: 343 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSV------RGY 396 ++F+A W C++ AP + +LS K G+ +VD ++ ++Y V + Sbjct: 122 VEFFANWSNDCQSFAPIYADLSLKY--NCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQL 179 Query: 397 PTLLLFRGGKK 407 PTL+LF+GGK+ Sbjct: 180 PTLILFQGGKE 190 Score = 41.6 bits (96), Expect = 0.001 Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 3/72 (4%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYN--SMEDAKVYVAK-VDCTAHSDVCSAQGVRGYPT 138 V FFA W CQ P + DL KYN + KV V + D + V ++ + PT Sbjct: 122 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLPT 181 Query: 139 LKLFKPGQEAVK 150 L LF+ G+EA++ Sbjct: 182 LILFQGGKEAMR 193 Score = 37.4 bits (85), Expect = 0.027 Identities = 21/70 (30%), Positives = 38/70 (54%), Gaps = 7/70 (10%) Query: 210 IKFFAPWCGHCKALAPTWEQLAL-----GLEHSETVKIGK-VDCTQHYELCSGNQVRGYP 263 ++FFA W C++ AP + L+L GL + V +G+ D + Y++ + + P Sbjct: 122 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGK-VDVGRYTDVSTRYKVSTSPLTKQLP 180 Query: 264 TLLWFRDGKK 273 TL+ F+ GK+ Sbjct: 181 TLILFQGGKE 190 >gi|7705726 thioredoxin domain containing 14 isoform 1 [Homo sapiens] Length = 296 Score = 43.1 bits (100), Expect = 5e-04 Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 8/71 (11%) Query: 343 IKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSV------RGY 396 ++F+A W C++ AP + +LS K G+ +VD ++ ++Y V + Sbjct: 160 VEFFANWSNDCQSFAPIYADLSLKY--NCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQL 217 Query: 397 PTLLLFRGGKK 407 PTL+LF+GGK+ Sbjct: 218 PTLILFQGGKE 228 Score = 41.6 bits (96), Expect = 0.001 Identities = 26/72 (36%), Positives = 37/72 (51%), Gaps = 3/72 (4%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYN--SMEDAKVYVAK-VDCTAHSDVCSAQGVRGYPT 138 V FFA W CQ P + DL KYN + KV V + D + V ++ + PT Sbjct: 160 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGKVDVGRYTDVSTRYKVSTSPLTKQLPT 219 Query: 139 LKLFKPGQEAVK 150 L LF+ G+EA++ Sbjct: 220 LILFQGGKEAMR 231 Score = 37.4 bits (85), Expect = 0.027 Identities = 21/70 (30%), Positives = 38/70 (54%), Gaps = 7/70 (10%) Query: 210 IKFFAPWCGHCKALAPTWEQLAL-----GLEHSETVKIGK-VDCTQHYELCSGNQVRGYP 263 ++FFA W C++ AP + L+L GL + V +G+ D + Y++ + + P Sbjct: 160 VEFFANWSNDCQSFAPIYADLSLKYNCTGLNFGK-VDVGRYTDVSTRYKVSTSPLTKQLP 218 Query: 264 TLLWFRDGKK 273 TL+ F+ GK+ Sbjct: 219 TLILFQGGKE 228 >gi|95113651 glutaredoxin 3 [Homo sapiens] Length = 335 Score = 42.0 bits (97), Expect = 0.001 Identities = 28/106 (26%), Positives = 44/106 (41%), Gaps = 9/106 (8%) Query: 308 SEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKE 367 +EA V A E G L A+ + + F+APW C + EL+ KE Sbjct: 6 AEAAVAAVEEVGSAGQFEELLRLK-----AKSLLVVHFWAPWAPQCAQMNEVMAELA-KE 59 Query: 368 FPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSG 413 P ++ VK+ + + KY + PT L F+ +K+ G Sbjct: 60 LPQVSFVKL---EAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDG 102 Score = 37.4 bits (85), Expect = 0.027 Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 9/73 (12%) Query: 210 IKFFAPWCGHCKALAPTWEQLALGLEHSETVKI---GKVDCTQHYELCSGNQVRGYPTLL 266 + F+APW C + +LA L VK+ G + ++ YE+ S PT L Sbjct: 36 VHFWAPWAPQCAQMNEVMAELAKELPQVSFVKLEAEGVPEVSEKYEISS------VPTFL 89 Query: 267 WFRDGKKVDQYKG 279 +F++ +K+D+ G Sbjct: 90 FFKNSQKIDRLDG 102 >gi|54633317 thioredoxin domain containing 11 [Homo sapiens] Length = 958 Score = 38.5 bits (88), Expect = 0.012 Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 2/75 (2%) Query: 199 FELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQ 258 +E+ + + D + ++APWCG C +L + QLA L +T + ++D +Q+ +L Sbjct: 674 WEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLP-MDTFTVARIDVSQN-DLPWEFM 731 Query: 259 VRGYPTLLWFRDGKK 273 V PT+L+F +K Sbjct: 732 VDRLPTVLFFPCNRK 746 Score = 32.7 bits (73), Expect = 0.66 Identities = 25/102 (24%), Positives = 50/102 (49%), Gaps = 7/102 (6%) Query: 328 TENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNI 387 T+ ++ + + + +YAPWCG C +L + +L+ + P + +A +D ++ ++ Sbjct: 670 TDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLA-RNLP-MDTFTVARID-VSQNDL 726 Query: 388 CSKYSVRGYPTLLLFRGGKKVSEHSGGRD----LDSLHRFVL 425 ++ V PT+L F +K D L +L RF+L Sbjct: 727 PWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFIL 768 Score = 30.8 bits (68), Expect = 2.5 Identities = 28/120 (23%), Positives = 53/120 (44%), Gaps = 17/120 (14%) Query: 82 VMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGY-PTLK 140 + F+APWCG + ++ + + D ++VA ++C + C Q Y P + Sbjct: 130 LFFYAPWCGQSIAARA---EIEQAASRLSDQVLFVA-INCWWNQGKCRKQKHFFYFPVIY 185 Query: 141 LFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFE 200 L+ ++Y+GP +E ++ + + +P + PS EL L SN+E Sbjct: 186 LYHRSFGPIEYKGPMSAVYIEKFVRRVM-------KPLLYIPSQSELLDFL-----SNYE 233 Score = 30.4 bits (67), Expect = 3.3 Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 9/122 (7%) Query: 62 SKHLYT---ADMFTHGI-QSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVA 117 S+HL T D F + Q ++++APWCG C L + L ++ VA Sbjct: 661 SQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLA---RNLPMDTFTVA 717 Query: 118 KVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQ-TLENWMLQTLNEEPVTPE 176 ++D + +D+ V PT+ F ++ + + P D TL N + L+ Sbjct: 718 RID-VSQNDLPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPASS 776 Query: 177 PE 178 P+ Sbjct: 777 PQ 778 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.135 0.425 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,598,386 Number of Sequences: 37866 Number of extensions: 889892 Number of successful extensions: 4087 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 36 Number of HSP's successfully gapped in prelim test: 34 Number of HSP's that attempted gapping in prelim test: 3760 Number of HSP's gapped (non-prelim): 253 length of query: 432 length of database: 18,247,518 effective HSP length: 105 effective length of query: 327 effective length of database: 14,271,588 effective search space: 4666809276 effective search space used: 4666809276 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.