Search of human proteins with 42740893

Search of human proteins with 42740893

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42740893 Ras association and pleckstrin homology domains 1
isoform 3 [Homo sapiens]
         (644 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42740893 Ras association and pleckstrin homology domains 1 is...  1274   0.0  
gi|47132519 Ras association and pleckstrin homology domains 1 is...  1145   0.0  
gi|56118221 amyloid beta (A4) precursor protein-binding, family ...   418   e-117
gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]    159   1e-38
gi|48762697 growth factor receptor-bound protein 10 isoform c [H...   152   9e-37
gi|48762695 growth factor receptor-bound protein 10 isoform c [H...   152   9e-37
gi|48762679 growth factor receptor-bound protein 10 isoform a [H...   152   9e-37
gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]     143   6e-34
gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]     143   6e-34
gi|48762693 growth factor receptor-bound protein 10 isoform b [H...    92   1e-18
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    48   2e-05
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...    48   3e-05
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   45   2e-04
gi|31982906 cingulin-like 1 [Homo sapiens]                             43   0.001
gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Hom...    40   0.005
gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Hom...    40   0.005
gi|55770834 centromere protein F [Homo sapiens]                        40   0.005
gi|39777586 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [Homo ...    40   0.007
gi|224586823 coiled-coil domain containing 110 isoform b [Homo s...    38   0.033
gi|22749515 coiled-coil domain containing 110 isoform a [Homo sa...    38   0.033
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho...    38   0.033
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       38   0.033
gi|221219020 NYD-SP11 protein [Homo sapiens]                           37   0.074
gi|154090979 hypothetical protein LOC57481 [Homo sapiens]              37   0.074
gi|110611218 ribosome binding protein 1 [Homo sapiens]                 36   0.096
gi|110611220 ribosome binding protein 1 [Homo sapiens]                 36   0.096
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ...    36   0.096
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [...    36   0.096
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [...    36   0.096
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H...    36   0.096

>gi|42740893 Ras association and pleckstrin homology domains 1
           isoform 3 [Homo sapiens]
          Length = 644

 Score = 1275 bits (3298), Expect = 0.0
 Identities = 644/644 (100%), Positives = 644/644 (100%)

Query: 1   MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET 60
           MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET
Sbjct: 1   MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET 60

Query: 61  NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK 120
           NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK
Sbjct: 61  NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK 120

Query: 121 LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK 180
           LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK
Sbjct: 121 LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK 180

Query: 181 PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ 240
           PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ
Sbjct: 181 PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ 240

Query: 241 PITEHAISLRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQA 300
           PITEHAISLRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQA
Sbjct: 241 PITEHAISLRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQA 300

Query: 301 AKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY 360
           AKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY
Sbjct: 301 AKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY 360

Query: 361 SLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL 420
           SLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL
Sbjct: 361 SLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL 420

Query: 421 GKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYV 480
           GKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYV
Sbjct: 421 GKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYV 480

Query: 481 PKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCD 540
           PKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCD
Sbjct: 481 PKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCD 540

Query: 541 DVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS 600
           DVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS
Sbjct: 541 DVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS 600

Query: 601 NHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK 644
           NHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK
Sbjct: 601 NHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK 644


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 1145 bits (2963), Expect = 0.0
 Identities = 590/644 (91%), Positives = 592/644 (91%), Gaps = 52/644 (8%)

Query: 1   MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET 60
           MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET
Sbjct: 1   MEQLSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQET 60

Query: 61  NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK 120
           NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK
Sbjct: 61  NMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQK 120

Query: 121 LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK 180
           LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK
Sbjct: 121 LPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTK 180

Query: 181 PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ 240
           PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ
Sbjct: 181 PLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQ 240

Query: 241 PITEHAISLRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQA 300
           P                                                    +T+EEQA
Sbjct: 241 P----------------------------------------------------ITEEEQA 248

Query: 301 AKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY 360
           AKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY
Sbjct: 249 AKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY 308

Query: 361 SLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL 420
           SLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL
Sbjct: 309 SLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLL 368

Query: 421 GKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYV 480
           GKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYV
Sbjct: 369 GKKETAEMADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYV 428

Query: 481 PKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCD 540
           PKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCD
Sbjct: 429 PKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCD 488

Query: 541 DVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS 600
           DVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS
Sbjct: 489 DVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS 548

Query: 601 NHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK 644
           NHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK
Sbjct: 549 NHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSK 592


>gi|56118221 amyloid beta (A4) precursor protein-binding, family B,
           member 1 interacting protein [Homo sapiens]
          Length = 666

 Score =  418 bits (1074), Expect = e-117
 Identities = 206/351 (58%), Positives = 267/351 (76%), Gaps = 20/351 (5%)

Query: 290 PSHLLTKEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVL 349
           P   L++EE+ A+ KA+KI++ALEK+KEA+VKKLV++VHM+D+S+K++MVDERQ  R VL
Sbjct: 145 PPEPLSQEEEEAQAKADKIKLALEKLKEAKVKKLVVKVHMNDNSTKSLMVDERQLARDVL 204

Query: 350 DNLMDKSHCGYSLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKY 409
           DNL +K+HC  ++DW L E   ELQ+ER FEDHEN+VE L +WTRD++NK++F+E+ EKY
Sbjct: 205 DNLFEKTHCDCNVDWCLYEIYPELQIERFFEDHENVVEVLSDWTRDTENKILFLEKEEKY 264

Query: 410 ALFKNPQNYLL---GKKETAE----MADRNKEVLLEECFCGSSVTVPEIEGVLWLKDDGK 462
           A+FKNPQN+ L   GKKE+ E    M  +NKE LLEE FCG+S+ VPE+EG L+LK+DGK
Sbjct: 265 AVFKNPQNFYLDNRGKKESKETNEKMNAKNKESLLEESFCGTSIIVPELEGALYLKEDGK 324

Query: 463 KSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVL 522
           KSWK+RYFLLRASGIYYVPKGK K SRDL CF+Q ++VN+YYG  ++ KYKAPTDYC VL
Sbjct: 325 KSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGTQHKMKYKAPTDYCFVL 384

Query: 523 KHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLS 582
           KHPQIQK+SQYIKYLCCDD RTL+QWV GIRIAKYGK LY NYQ A+ +   A  WT+L 
Sbjct: 385 KHPQIQKESQYIKYLCCDDTRTLNQWVMGIRIAKYGKTLYDNYQRAVAKAGLASRWTNLG 444

Query: 583 SSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPAGHV-RSQSIVSSVFSEA 632
           + +  + +  S+ P++              TQP G + ++   VS+V  EA
Sbjct: 445 TVNAAAPAQPSTGPKT------------GTTQPNGQIPQATHSVSAVLQEA 483



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 34/75 (45%), Positives = 42/75 (56%), Gaps = 6/75 (8%)

Query: 19 KEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQETNMANFSYRFSIYNLNEAL 78
          +  +D+D+MF   LGE+D LTQSL  D    P    P       A F+Y     +LNE+L
Sbjct: 3  ESSEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPP------RAEFNYSVGFKDLNESL 56

Query: 79 NQGETVDLDALMADL 93
          N  E  DLDALMADL
Sbjct: 57 NALEDQDLDALMADL 71


>gi|71979663 growth factor receptor-bound protein 14 [Homo sapiens]
          Length = 540

 Score =  159 bits (401), Expect = 1e-38
 Identities = 99/278 (35%), Positives = 146/278 (52%), Gaps = 9/278 (3%)

Query: 321 KKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFE 380
           KK VI+V+  D++S+ + V    T R V   L+ K+H      W+L E +  + +ER  E
Sbjct: 106 KKQVIKVYSEDETSRALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIE 165

Query: 381 DHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEV---LL 437
           DHE ++E L NW  + +NKL F +   KY  FKNP  Y   +   +   + N E+    +
Sbjct: 166 DHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPM-YFFPEHMVSFATETNGEISPTQI 224

Query: 438 EECFCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQL 497
            + F  SS T PEI G L  K+ GKKSWKK YF LR SG+Y+  KG +K  R L  F + 
Sbjct: 225 LQMFLSSS-TYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEF 283

Query: 498 DHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKY 557
            + ++Y     + K+ APT+Y    K P      + +K LC ++ ++   WV  IR+ KY
Sbjct: 284 GNSDIYVSLAGKKKHGAPTNYGFCFK-PNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKY 342

Query: 558 GKQLYMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSI 595
           G QLY NY    +        +S S S ++S S +S +
Sbjct: 343 GMQLYQNYMHPYQGRSGC---SSQSISPMRSISENSLV 377


>gi|48762697 growth factor receptor-bound protein 10 isoform c [Homo
           sapiens]
          Length = 536

 Score =  152 bits (384), Expect = 9e-37
 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)

Query: 325 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 384
           ++V   D +SK + +    T R +   L+ KSHC     W+LVE    L +ER  EDHE 
Sbjct: 112 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 171

Query: 385 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 444
           +V+  +  T  S++K +F +   KY  FKNP N+   +  T        +  L + F  S
Sbjct: 172 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 229

Query: 445 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 504
           S + PEI+G L +K+ GKKSWKK Y  LR SG+Y   KG +K  R L     L+  N++ 
Sbjct: 230 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 288

Query: 505 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 564
               R +Y APTD+ L +K  +++ +++ ++ LC +D +T   W+   R+ KYG  LY N
Sbjct: 289 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 348

Query: 565 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 616
           Y+   +R        S  S+ ++S S +S +    S  + +     ++ Q A
Sbjct: 349 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 396


>gi|48762695 growth factor receptor-bound protein 10 isoform c [Homo
           sapiens]
          Length = 536

 Score =  152 bits (384), Expect = 9e-37
 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)

Query: 325 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 384
           ++V   D +SK + +    T R +   L+ KSHC     W+LVE    L +ER  EDHE 
Sbjct: 112 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 171

Query: 385 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 444
           +V+  +  T  S++K +F +   KY  FKNP N+   +  T        +  L + F  S
Sbjct: 172 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 229

Query: 445 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 504
           S + PEI+G L +K+ GKKSWKK Y  LR SG+Y   KG +K  R L     L+  N++ 
Sbjct: 230 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 288

Query: 505 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 564
               R +Y APTD+ L +K  +++ +++ ++ LC +D +T   W+   R+ KYG  LY N
Sbjct: 289 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 348

Query: 565 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 616
           Y+   +R        S  S+ ++S S +S +    S  + +     ++ Q A
Sbjct: 349 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 396


>gi|48762679 growth factor receptor-bound protein 10 isoform a [Homo
           sapiens]
          Length = 594

 Score =  152 bits (384), Expect = 9e-37
 Identities = 95/292 (32%), Positives = 150/292 (51%), Gaps = 7/292 (2%)

Query: 325 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 384
           ++V   D +SK + +    T R +   L+ KSHC     W+LVE    L +ER  EDHE 
Sbjct: 170 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 229

Query: 385 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCGS 444
           +V+  +  T  S++K +F +   KY  FKNP N+   +  T        +  L + F  S
Sbjct: 230 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQNFLNS 287

Query: 445 SVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYY 504
           S + PEI+G L +K+ GKKSWKK Y  LR SG+Y   KG +K  R L     L+  N++ 
Sbjct: 288 S-SCPEIQGFLHVKELGKKSWKKLYVCLRRSGLYCSTKGTSKEPRHLQLLADLEDSNIFS 346

Query: 505 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 564
               R +Y APTD+ L +K  +++ +++ ++ LC +D +T   W+   R+ KYG  LY N
Sbjct: 347 LIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQN 406

Query: 565 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 616
           Y+   +R        S  S+ ++S S +S +    S  + +     ++ Q A
Sbjct: 407 YRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 454


>gi|71979665 growth factor receptor-bound protein 7 [Homo sapiens]
          Length = 532

 Score =  143 bits (360), Expect = 6e-34
 Identities = 84/284 (29%), Positives = 143/284 (50%), Gaps = 5/284 (1%)

Query: 324 VIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHE 383
           V++V+  D + +++ V    T R V + L+ ++H      W LVE    L +ER  EDHE
Sbjct: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162

Query: 384 NLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCG 443
           ++VE    W     ++ +F +   KY LFK+  + L  +K  +   D +  +  E+    
Sbjct: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQN 222

Query: 444 --SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVN 501
             ++ + PEI+G L L+  G+K WK+ +  LR SG+YY  KG +K  R L     ++  N
Sbjct: 223 FLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESN 282

Query: 502 VYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQL 561
           VY     R  Y  PTD+   +K  +++   + ++  C +D ++   W+   R+ KYG QL
Sbjct: 283 VYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQL 342

Query: 562 YMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQ 605
           Y NYQ+A  R       + L S  ++S S ++ +    S H+ +
Sbjct: 343 YKNYQQAQSRHLHP---SCLGSPPLRSASDNTLVAMDFSGHAGR 383


>gi|71979667 growth factor receptor-bound protein 7 [Homo sapiens]
          Length = 532

 Score =  143 bits (360), Expect = 6e-34
 Identities = 84/284 (29%), Positives = 143/284 (50%), Gaps = 5/284 (1%)

Query: 324 VIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHE 383
           V++V+  D + +++ V    T R V + L+ ++H      W LVE    L +ER  EDHE
Sbjct: 103 VVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDETWGLVECHPHLALERGLEDHE 162

Query: 384 NLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCG 443
           ++VE    W     ++ +F +   KY LFK+  + L  +K  +   D +  +  E+    
Sbjct: 163 SVVEVQAAWPVGGDSRFVFRKNFAKYELFKSSPHSLFPEKMVSSCLDAHTGISHEDLIQN 222

Query: 444 --SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVN 501
             ++ + PEI+G L L+  G+K WK+ +  LR SG+YY  KG +K  R L     ++  N
Sbjct: 223 FLNAGSFPEIQGFLQLRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADVNESN 282

Query: 502 VYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQL 561
           VY     R  Y  PTD+   +K  +++   + ++  C +D ++   W+   R+ KYG QL
Sbjct: 283 VYVVTQGRKLYGMPTDFGFCVKPNKLRNGHKGLRIFCSEDEQSRTCWLAAFRLFKYGVQL 342

Query: 562 YMNYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQ 605
           Y NYQ+A  R       + L S  ++S S ++ +    S H+ +
Sbjct: 343 YKNYQQAQSRHLHP---SCLGSPPLRSASDNTLVAMDFSGHAGR 383


>gi|48762693 growth factor receptor-bound protein 10 isoform b [Homo
           sapiens]
          Length = 548

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 72/293 (24%), Positives = 125/293 (42%), Gaps = 55/293 (18%)

Query: 325 IRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHEN 384
           ++V   D +SK + +    T R +   L+ KSHC     W+LVE    L +ER  EDHE 
Sbjct: 170 VKVFSEDGTSKVVEILADMTARDLCQLLVYKSHCVDDNSWTLVEHHPHLGLERCLEDHEL 229

Query: 385 LVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKET-AEMADRNKEVLLEECFCG 443
           +V+  +  T  S++K +F +   KY  FKNP N+   +  T  + ++ ++  LL+E    
Sbjct: 230 VVQ--VESTMASESKFLFRKNYAKYEFFKNPMNFFPEQMVTWCQQSNGSQTQLLQE---- 283

Query: 444 SSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVY 503
                                                        R L     L+  N++
Sbjct: 284 --------------------------------------------PRHLQLLADLEDSNIF 299

Query: 504 YGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYM 563
                R +Y APTD+ L +K  +++ +++ ++ LC +D +T   W+   R+ KYG  LY 
Sbjct: 300 SLIAGRKQYNAPTDHGLCIKPNKVRNETKELRLLCAEDEQTRTCWMTAFRLLKYGMLLYQ 359

Query: 564 NYQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQSNHSNQSDSGVSDTQPA 616
           NY+   +R        S  S+ ++S S +S +    S  + +     ++ Q A
Sbjct: 360 NYRIPQQRKA----LLSPFSTPVRSVSENSLVAMDFSGQTGRVIENPAEAQSA 408


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 88/447 (19%), Positives = 186/447 (41%), Gaps = 68/447 (15%)

Query: 4    LSDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQETNMA 63
            + D E  H A    DK+ ++ DK+   W  +LD      +S   +E  ++      T + 
Sbjct: 1433 MRDLERSHTACATLDKKQRNFDKVLAEWKQKLD------ESQAELEAAQKESRSLSTEL- 1485

Query: 64   NFSYRFSIYNLNEALNQGETVD-LDALMADLCSIEQELSSIGS--GNSKRQITETKATQK 120
                 F + N  E     E VD L+ L  +  ++++E+S +      + + + E + T+K
Sbjct: 1486 -----FKMRNAYE-----EVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKK 1535

Query: 121  LPVSRHTLKHGTLKGLSSS-SNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDT 179
            L     +     L+ +  S  +  +K       L  V ++L++  +  DE  +Q      
Sbjct: 1536 LVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQ------ 1589

Query: 180  KPLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQG 239
              L  N  R   +  +V DAE+      S +        M+  D++++    E+ L H  
Sbjct: 1590 --LKRNSQRAAEALQSVLDAEIR-----SRNDALRLKKKMEG-DLNEM----EIQLGHSN 1637

Query: 240  QPITE---HAISLRCSSKQAKRHIDFTEEQAELTPH--SYLDRETSLLLRNIAGKPSHLL 294
            + + E   H  +++   K ++ H+D      E      + ++R   LLL  +  +    L
Sbjct: 1638 RQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELE-EMKVAL 1696

Query: 295  TKEEQAAKLKAEKIRVALEKIK--EAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNL 352
             + E+  +L  +++  A ++++   +Q   L+       ++ K +  D  Q   +V +++
Sbjct: 1697 EQTERTRRLSEQELLDASDRVQLLHSQNTSLI-------NTKKKLEADIAQCQAEVENSI 1749

Query: 353  MDKSHCGYSLDWSLVET---VSELQMERIFEDH-ENLVENLLNWTRDSQNKLIFMERIEK 408
             +  +       ++ +      EL+ E+    H E + +NL    +D Q++L   +  E+
Sbjct: 1750 QESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL---DEAEQ 1806

Query: 409  YALFKNPQNYLLGKKETAEMADRNKEV 435
             AL         GKK+  ++ +R +E+
Sbjct: 1807 LALKG-------GKKQIQKLENRVREL 1826



 Score = 30.8 bits (68), Expect = 4.0
 Identities = 53/278 (19%), Positives = 118/278 (42%), Gaps = 47/278 (16%)

Query: 71   IYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQKLPVSRHTLKH 130
            +  L E L + E ++ + L+A   ++E + SS+       ++T TK  ++        KH
Sbjct: 923  VKELTERLEEEEEMNSE-LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKE--------KH 973

Query: 131  GTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSV--LEDTKPLVTNQHR 188
             T        N++   S    +L++  ++L +   S+ EA QQ++  L+  +  V    +
Sbjct: 974  AT-------ENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIK 1026

Query: 189  RTASAGTVSD-------------AEVHSISNSSHSSITSAASSM-----DSLDIDKVTRP 230
              A     +D             A++          +  +  S+     D   I++  + 
Sbjct: 1027 INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKK 1086

Query: 231  QELDLTHQGQPITE---HAISLRCSSKQAKRHIDFTEE--QAELTPHSYLDRETSLLLRN 285
            +E +L+     I +   H++  +   K+ +  I+  EE  +AE T  + ++++ S L R 
Sbjct: 1087 KEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE 1146

Query: 286  IAGKPSHLLTKEEQAAKLKAEKIRVALEKIKEAQVKKL 323
            +      +  + E+A+   A   ++ + K +EA+ +K+
Sbjct: 1147 L----EEISERLEEAS--GATSAQIEMNKKREAEFQKM 1178


>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
            [Homo sapiens]
          Length = 1704

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 52/215 (24%), Positives = 89/215 (41%), Gaps = 42/215 (19%)

Query: 364  WSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKK 423
            W+  E +   ++ER     EN++E +L W+                +L +    YL+ K+
Sbjct: 1374 WATFEVIENEELERPLHYKENVLEQVLRWS----------------SLAEPGSAYLVVKR 1417

Query: 424  ETAEMADRNKEVLLEECFCGSSVTVPEI-EGVLWLKDDGKK-----SWKKRYFLLRASGI 477
                 AD  K        C    T+  I EG+L +K++  K      ++ RYF+LR  G 
Sbjct: 1418 FLT--ADTIKH-------CSDRSTLGSIKEGILKIKEEPSKILSGNKFQDRYFVLR-DGF 1467

Query: 478  YYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYL 537
             ++ K       D +    L  +  Y G   + K K PT + L           ++  +L
Sbjct: 1468 LFLYKDVKSSKHDKM--FSLSSMKFYRG--VKKKMKPPTSWGLTAY------SEKHHWHL 1517

Query: 538  CCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRT 572
            CCD  RT  +W+  I IA++   ++    +  KR+
Sbjct: 1518 CCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRS 1552


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 108/516 (20%), Positives = 209/516 (40%), Gaps = 94/516 (18%)

Query: 5   SDEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKP----------------- 47
           ++EEI      + +KE++ L +  G +  EL+ L + L   K                  
Sbjct: 386 AEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNS 445

Query: 48  -----MEPVKRSPLRQETNMAN----FSYRFSIYNLNEALN-----QGETVDL-----DA 88
                +   ++S L+ E+ + N       +FS+ N N  L      Q E +DL     ++
Sbjct: 446 EVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIES 505

Query: 89  LMADLCSIEQELSSIGSGNSKRQITETKA-TQKLPVSRHTLKHGTLKGLSSSSNRIAKPS 147
              +L S+E+ +S +     KR++   K+   K  +S  + K     G   ++  +    
Sbjct: 506 SRVELRSLEKIISQLPL---KRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISEL 562

Query: 148 HASYSLDD---------VTA-QLEQASLSMDEAAQQSVLE--DTKPLVTNQHRRTASAGT 195
               ++ +         +TA QL Q+ ++ +++ + S L   +T+P+    H+    A +
Sbjct: 563 RIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQ---VAES 619

Query: 196 VSDAEVHSISNSSHSSITSAASSMDSL-----DIDKVTRPQELDLTH---QGQPITEHAI 247
           V D   H+++           + ++ L      I+      ++++ H   Q Q I E   
Sbjct: 620 VKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEEL- 678

Query: 248 SLRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHL----LTKEEQAAKL 303
            L  +S  +K   + T++ ++L        E  +   +IA K + L    + K E+   L
Sbjct: 679 -LEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSL 737

Query: 304 KA------EKIRVALEKIK----------EAQVKKLVIRVHMSDDSSKTMMVDERQTVRQ 347
           +       EKI +A EK K          E Q+++L  ++   D   K    ++ +T+  
Sbjct: 738 ETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFK----EQEKTMSM 793

Query: 348 VLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHE-NLVENLLNWTRDSQNKLIFMERI 406
           +  +++ K H   SLD  L E+  E++ E + +D     ++N ++       +L     I
Sbjct: 794 LQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEI 853

Query: 407 EKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFC 442
            K  L  +  N L G KE  E   + K    EE +C
Sbjct: 854 CKEELVLH-LNQLEGNKEKFEKQLKKKS---EEVYC 885


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 42.7 bits (99), Expect = 0.001
 Identities = 73/398 (18%), Positives = 162/398 (40%), Gaps = 27/398 (6%)

Query: 14   EEDSDKEDQDLDKMFGAWLGELDKLTQSL-DSDKPMEPVKRSPLRQETNMANFSYRFSIY 72
            +E+    DQ++DK+   +  EL  L +S+ ++ K +E +       E + A    R  + 
Sbjct: 768  KEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLL 827

Query: 73   NLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQKLPVSRHTLKHGT 132
                   QG + +L+  +A L   ++++  +    +K + T  K   ++      L H  
Sbjct: 828  QEENEKLQGRSEELERRVAQL---QRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHAR 884

Query: 133  LKGLSSSSNRIAKPSH---ASYSLDDVTAQLEQASLSMDEAAQQSVLEDTKPLVTNQHRR 189
             +   + S R A  +    A  +L   T + +Q S  + E ++Q   E  + L       
Sbjct: 885  KEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQK--EQLRRLKNEMENE 942

Query: 190  TASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQEL-DLTHQGQPITEHAIS 248
                G   +     +++   +S TS     + LD  K    +EL ++  Q +  T  A  
Sbjct: 943  RWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEK 1002

Query: 249  LRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQAAKLKAEKI 308
             R ++ + +  +   EE  EL  +     E     + +      L  + E  + LK ++ 
Sbjct: 1003 SRLTAMKMQDEMRLMEE--ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRS 1060

Query: 309  RVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDE-----RQTVRQVLDNLMDKSHCGYSLD 363
            R+    +K+ + K   + + + ++ + + ++ E     R+ + Q+ + L+ +      L+
Sbjct: 1061 RL----VKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLE 1116

Query: 364  WSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLI 401
                    ++ +ER  +D ++ + +L    R S+  L+
Sbjct: 1117 ------CDKISLERQNKDLKSRIIHLEGSYRSSKEGLV 1148


>gi|189409130 zinc finger E-box binding homeobox 1 isoform a [Homo
            sapiens]
          Length = 1108

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 19/115 (16%)

Query: 7    EEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQETNMANFS 66
            E +    +EDS+KE+++ DK       E+++L +  + +KP    +     +E       
Sbjct: 1010 ESLTREEDEDSEKEEEEEDK-------EMEELQEEKECEKPQGDEEEEEEEEEVEEE--- 1059

Query: 67   YRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGS--GNSKRQITETKATQ 119
                   + EA N+GE    + LM D    E + SS+G   G S  Q++E K  +
Sbjct: 1060 ------EVEEAENEGEEAKTEGLMKD-DRAESQASSLGQKVGESSEQVSEEKTNE 1107


>gi|189409128 zinc finger E-box binding homeobox 1 isoform b [Homo
            sapiens]
          Length = 1124

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 19/115 (16%)

Query: 7    EEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQETNMANFS 66
            E +    +EDS+KE+++ DK       E+++L +  + +KP    +     +E       
Sbjct: 1026 ESLTREEDEDSEKEEEEEDK-------EMEELQEEKECEKPQGDEEEEEEEEEVEEE--- 1075

Query: 67   YRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGS--GNSKRQITETKATQ 119
                   + EA N+GE    + LM D    E + SS+G   G S  Q++E K  +
Sbjct: 1076 ------EVEEAENEGEEAKTEGLMKD-DRAESQASSLGQKVGESSEQVSEEKTNE 1123


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 99/476 (20%), Positives = 207/476 (43%), Gaps = 64/476 (13%)

Query: 13   AEEDSDKEDQDLDK---MFGAWLGELDKLTQSLDSDKPMEPVKRSPLR-----QETNMAN 64
            A E   KE ++L +   +F  W  E +KL   ++S+K     K + L      Q+     
Sbjct: 601  ALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHE 660

Query: 65   FSYR------------FSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQI 112
            ++ R              I NL+  L+  ++V+++        ++Q+       + K   
Sbjct: 661  YNERVRTLEMDRENLSVEIRNLHNVLD-SKSVEVETQKLAYMELQQKAEFSDQKHQKEIE 719

Query: 113  TETKATQKLPVSRHTLKHGTLKGLSS---SSNRIAKPSHASY-SLDDVTAQLEQASLSMD 168
                 T +L      L+H  L+ LS+     +R  +  HA Y SL D+  + + ASL  +
Sbjct: 720  NMCLKTSQLTGQVEDLEH-KLQLLSNEIMDKDRCYQDLHAEYESLRDL-LKSKDASLVTN 777

Query: 169  EAAQQSVLE-DTKPLVTNQH-----RRTASAGTVSDAEVHSISNSSHSSITSAASSMDSL 222
            E  Q+S+L  D +P + +        + +     S+  + +  +  +S+I    + +DSL
Sbjct: 778  EDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQ--NRVDSL 835

Query: 223  DIDKVTRPQ-ELDLTHQGQPITEHAISLRCSSKQAKR-HIDFTEEQAELTPHSYLDRETS 280
            +    ++ Q   DL  Q + + +    +  +  +A++ H  F  E ++    S L  +TS
Sbjct: 836  EFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRI--SKLQEDTS 893

Query: 281  LLLRNIAGKPSHLLTKEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDS------- 333
               +N+  +    L  +E+  +L  +K+     + ++A++++L    H+ +DS       
Sbjct: 894  -AHQNVVAETLSALENKEKELQLLNDKV-----ETEQAEIQELKKSNHLLEDSLKELQLL 947

Query: 334  SKTMMVDERQTV------RQVLDNLMDKSHCGYSLDWSL-VETVSELQMERIFEDHENLV 386
            S+T+ +++++        ++ ++ L  ++     ++ SL  E ++ +Q    F ++ +  
Sbjct: 948  SETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER 1007

Query: 387  ENLLNWTRD--SQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEEC 440
            E  ++   D   Q KLI ++R E+     N    L  K + A+  +   E LL EC
Sbjct: 1008 EKSISELSDQYKQEKLILLQRCEETG---NAYEDLSQKYKAAQEKNSKLECLLNEC 1060


>gi|39777586 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 [Homo
           sapiens]
          Length = 1386

 Score = 40.0 bits (92), Expect = 0.007
 Identities = 50/212 (23%), Positives = 95/212 (44%), Gaps = 48/212 (22%)

Query: 288 GKPSHLLTKEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSD-DSSKTMMVDERQTVR 346
           G P     K+    KLKA + R A E+++E     L + +H+ D DS K  + D++   +
Sbjct: 746 GSPYMRSMKQISKEKLKARRNRTAFEEVEE----DLRLSLHLQDQDSVKDAVPDQQLDFK 801

Query: 347 QVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNK------L 400
           Q+L      S        S+++T+S +  E++   +  L+E LL W  D ++       L
Sbjct: 802 QLLARYKGVSK-------SVIKTMSIMDFEKV---NLELIEALLEWIVDGKHSYPPGAIL 851

Query: 401 IFM----------ERIEKYALFKN---------PQNYLLGKKETAEMADRN----KEVLL 437
           +F+          E+++  +LF N         P +  L  +E   +  +      ++++
Sbjct: 852 VFLPGLAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIII 911

Query: 438 EECFCGSSVTVPEIEGVLWLKDDGKKSWKKRY 469
                 +S+T   I+ V+++ D GK   +KRY
Sbjct: 912 STNIAETSIT---IDDVVYVIDSGKMK-EKRY 939


>gi|224586823 coiled-coil domain containing 110 isoform b [Homo
           sapiens]
          Length = 796

 Score = 37.7 bits (86), Expect = 0.033
 Identities = 49/194 (25%), Positives = 85/194 (43%), Gaps = 37/194 (19%)

Query: 295 TKEEQAAKLKAEK--IRVALEKIKE------AQVKKLVIRVHMSDDSSKTM------MVD 340
           T E+Q   L  EK  I+  L K +E       + KK++ + ++    +KT+      +  
Sbjct: 438 TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 497

Query: 341 ERQTVRQVLDNLMDKSHCGYSLDWSLVETVSE---LQMER------IFEDHENLVE---- 387
           E+Q + + LD L  K H   S D ++V   +    ++ME       + +D + ++E    
Sbjct: 498 EKQQMMEALDQLKSKEHKTQS-DMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTH 556

Query: 388 -------NLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEEC 440
                  +L N  ++SQ ++I ++  EK  L K  Q  LL   ET +    N E  L+E 
Sbjct: 557 QLLKEKSSLGNELKESQLEIIQLK--EKERLAKTEQETLLQIIETVKDEKLNLETTLQES 614

Query: 441 FCGSSVTVPEIEGV 454
                +   EIE +
Sbjct: 615 TAARQIMEREIENI 628


>gi|22749515 coiled-coil domain containing 110 isoform a [Homo
           sapiens]
          Length = 833

 Score = 37.7 bits (86), Expect = 0.033
 Identities = 49/194 (25%), Positives = 85/194 (43%), Gaps = 37/194 (19%)

Query: 295 TKEEQAAKLKAEK--IRVALEKIKE------AQVKKLVIRVHMSDDSSKTM------MVD 340
           T E+Q   L  EK  I+  L K +E       + KK++ + ++    +KT+      +  
Sbjct: 475 TYEKQLKNLVEEKSTIQSKLSKTEEYSKECLKEFKKIISKYNVLQGQNKTLEEKNIQLSL 534

Query: 341 ERQTVRQVLDNLMDKSHCGYSLDWSLVETVSE---LQMER------IFEDHENLVE---- 387
           E+Q + + LD L  K H   S D ++V   +    ++ME       + +D + ++E    
Sbjct: 535 EKQQMMEALDQLKSKEHKTQS-DMAIVNNENNRMSIEMEAMKTNILLIQDEKEMLEKKTH 593

Query: 388 -------NLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEEC 440
                  +L N  ++SQ ++I ++  EK  L K  Q  LL   ET +    N E  L+E 
Sbjct: 594 QLLKEKSSLGNELKESQLEIIQLK--EKERLAKTEQETLLQIIETVKDEKLNLETTLQES 651

Query: 441 FCGSSVTVPEIEGV 454
                +   EIE +
Sbjct: 652 TAARQIMEREIENI 665


>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
           sapiens]
          Length = 1034

 Score = 37.7 bits (86), Expect = 0.033
 Identities = 37/156 (23%), Positives = 63/156 (40%), Gaps = 30/156 (19%)

Query: 450 EIEGVLWLKDDGK----KSWKKRYFLLRASGIY-YVPKGKAKVSRDLVCFLQLDHVNVYY 504
           + EG LW K D K    + WKK +F+L+ + +Y Y+ +   K       F+ L    +  
Sbjct: 572 DCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEG----FISLPEFKIDR 627

Query: 505 GQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMN 564
             + R K      Y     HP+I+       Y   + +  +++W+N I +   G      
Sbjct: 628 ASECRKK------YAFKACHPKIKS-----FYFAAEHLDDMNRWLNRINMLTAG------ 670

Query: 565 YQEALKRTESAYDWTSLSSSSIKSGSSSSSIPESQS 600
           Y E  +  +    W    S S K  + + S P+  S
Sbjct: 671 YAERERIKQEQDYW----SESDKEEADTPSTPKQDS 702


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 37.7 bits (86), Expect = 0.033
 Identities = 53/264 (20%), Positives = 106/264 (40%), Gaps = 43/264 (16%)

Query: 71   IYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQKLPVSRHTLKH 130
            +  +NE L   E ++ + L A    +E E S +       ++T  K  ++        KH
Sbjct: 921  VKEMNERLEDEEEMNAE-LTAKKRKLEDECSELKKDIDDLELTLAKVEKE--------KH 971

Query: 131  GTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTKPLVTNQHRRT 190
             T        N++   +     LD++ A+L +   ++ EA QQ+ L+D +          
Sbjct: 972  AT-------ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQA-LDDLQ---------- 1013

Query: 191  ASAGTVSDAEVHSISNSS---HSSITSAASSMDS-----LDIDKVTRPQELDLTHQGQPI 242
                 V + +V+S+S S       +     S++      +D+++  R  E DL    + I
Sbjct: 1014 -----VEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1068

Query: 243  TE-HAISLRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHL--LTKEEQ 299
             +     L+   K  K+  D  ++ +++     L  +    L+    +   L    + E+
Sbjct: 1069 MDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAER 1128

Query: 300  AAKLKAEKIRVALEKIKEAQVKKL 323
             A+ K EK+R  L +  E   ++L
Sbjct: 1129 TARAKVEKLRSDLSRELEEISERL 1152



 Score = 34.3 bits (77), Expect = 0.37
 Identities = 74/407 (18%), Positives = 159/407 (39%), Gaps = 40/407 (9%)

Query: 6    DEEIDHGAEEDSDKEDQDLDKMFGAWLGELDKLTQSLDSDKPMEPVKRSPLRQETNMANF 65
            D E  + A    DK+ ++ DK+   W  + ++    L+S +     +   L  E      
Sbjct: 1433 DVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK----EARSLSTELFKLKN 1488

Query: 66   SYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQKLPVSR 125
            +Y  S+ +L     + +      L  ++  + ++L   G    + +    K  ++L V +
Sbjct: 1489 AYEESLEHLETFKRENKN-----LQEEISDLTEQLGEGGKNVHELE----KVRKQLEVEK 1539

Query: 126  HTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDTKPLVTN 185
              L+    +  +S  +   K   A    + + A++E+     DE  +Q+          N
Sbjct: 1540 LELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA--------KRN 1591

Query: 186  QHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQGQPITE- 244
              R   S  T  DAE       S + +      M+  D++++    E+ L+H  +   E 
Sbjct: 1592 HQRVVDSLQTSLDAETR-----SRNEVLRVKKKMEG-DLNEM----EIQLSHANRMAAEA 1641

Query: 245  --HAISLRCSSKQAKRHI-DFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQAA 301
                 SL+   K  +  + D      +L  +  +    + LL+    +   ++ + E++ 
Sbjct: 1642 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSR 1701

Query: 302  KLKAEKIRVALEKIKEAQVKKL-VIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGY 360
            KL  +++    E+++    +   +I      +S  T +  E +   Q   N  +K+    
Sbjct: 1702 KLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAI 1761

Query: 361  SLDWSLVETVSELQMERIFEDH-ENLVENLLNWTRDSQNKLIFMERI 406
            +    + E   EL+ E+    H E + +N+    +D Q++L   E+I
Sbjct: 1762 TDAAMMAE---ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 36.6 bits (83), Expect = 0.074
 Identities = 40/171 (23%), Positives = 78/171 (45%), Gaps = 12/171 (7%)

Query: 217  SSMDSLDIDKVTRPQELDLTHQGQPITEHAISLRCSSKQAKRHIDFTEEQAELTPHSYLD 276
            +SM+ L  +K+   Q+ +L  + + + +         K A+R  +    +  LT HS   
Sbjct: 1821 NSMEELTKNKMILYQKKNLAQEKKNLAQE------KEKLAQRKENLLYNKERLT-HS--- 1870

Query: 277  RETSLLLRNIAGKPSHLLTKEEQAAKLKAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKT 336
            ++  + ++N  G  + +L + E+  KL  EK  V  +K K A+ +K +++V  S    + 
Sbjct: 1871 KKQLVQVKNKLGMFNKILAQVEE--KLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQE 1928

Query: 337  MMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHENLVE 387
             +  E+  +      +  K      LD +  E    L+M+R+ E+   LVE
Sbjct: 1929 KLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVE 1979


>gi|154090979 hypothetical protein LOC57481 [Homo sapiens]
          Length = 1709

 Score = 36.6 bits (83), Expect = 0.074
 Identities = 87/435 (20%), Positives = 156/435 (35%), Gaps = 64/435 (14%)

Query: 33  GELDKLTQSLDSDKPMEPVKRSPLRQETNMANFSYRFSIYNLNEALNQGETVDLDALMAD 92
           G L  +TQ+L++    EP+   P  +E N+   S         + +N+ + + +D+  AD
Sbjct: 439 GSLQCVTQTLETPNLDEPLPVEPKEEEPNLPLVSEEEKSITKPKEINE-KKLGMDS--AD 495

Query: 93  LCSIEQELSSIGSGNSKRQITETKATQKLPVS----------------RHTLKHGTLKGL 136
             S +Q        N+K ++ + K T + P +                R   K  ++ GL
Sbjct: 496 SSSQKQ--------NNKTEMYDKKTTDQAPNTDASRSQGYPMSAAYGRRWRRKGASVSGL 547

Query: 137 SSS--SNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLE--DTKPLVTNQHRRTAS 192
           S      R  K S   Y L D          + +       LE  + +   T+Q   T  
Sbjct: 548 SGCEFKGRSLKQSSEGYGLGDRAGSSPTNKTARNVPFSHLSLEKDNMEQPTTSQPETTTP 607

Query: 193 AGTVSDAEVHSISNSS---HSSITSAASSM-DSLDIDKVTRPQELDLTHQGQPITEHAIS 248
            G +SD +     N+     S   SAA  + +++D   V+ PQ     H+          
Sbjct: 608 QGLLSDKDDMGRRNAGIDFGSRKASAAQPIPENMDNSMVSDPQPY---HEDAASGAEKTE 664

Query: 249 LRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLLTKEEQAAKLKAEKI 308
            R S       +  T+E+A L+    +  E  + +      PSH+  ++++A     +K 
Sbjct: 665 ARASLSLMVESLSTTQEEAILS----VAAEAQVFM-----NPSHIQLEDQEAFSFDLQKA 715

Query: 309 RVALEKIKEAQV---KKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWS 365
           +  +E  ++ Q    +K    VH +  +S   M             L  +         S
Sbjct: 716 QSKMESAQDVQTICKEKPSGNVHQTFTASVLGMTSTTAKGDVYAKTLPPR---------S 766

Query: 366 LVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKET 425
           L ++  +   E +  D EN+ E       D   +L      +    F++ Q      K  
Sbjct: 767 LFQSSRKPDAEEVSSDSENIPEE-----GDGSEELAHGHSSQSLGKFEDEQEVFSESKSF 821

Query: 426 AEMADRNKEVLLEEC 440
            E    ++E L   C
Sbjct: 822 VEDLSSSEEELDLRC 836


>gi|110611218 ribosome binding protein 1 [Homo sapiens]
          Length = 977

 Score = 36.2 bits (82), Expect = 0.096
 Identities = 70/317 (22%), Positives = 123/317 (38%), Gaps = 54/317 (17%)

Query: 60  TNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQ 119
           T +A      SI  L +ALNQ  +       A+L  + QELS +    SK  + +++A +
Sbjct: 360 TQLARLQQENSI--LRDALNQATSQVESKQNAELAKLRQELSKV----SKELVEKSEAVR 413

Query: 120 KLPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDT 179
           +    R  L+              AK +    + +    QL+ +    +EA Q+ + E +
Sbjct: 414 QDEQQRKALE--------------AKAA----AFEKQVLQLQASHRESEEALQKRLDEVS 455

Query: 180 KPLVTNQHRRTASAGTVSD-----------AEVHSISNSSHSSITSAASSMDSLDIDKVT 228
           + L    H +++ A   +D           AE+HS   SS + + S    +  L      
Sbjct: 456 RELC---HTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGL------ 506

Query: 229 RPQELDLTHQGQPITEHAISLRC--SSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNI 286
             Q  +   +   +TE   S+     + QA+   D    QAE        +E    +  +
Sbjct: 507 HGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGL 566

Query: 287 AGKPSHLLTKEEQAAKLKAEKIR-------VALEKIKEAQVKKLVIRVHMSDDSSKTMMV 339
             +   L    EQ  K+K   +R        AL   ++A  +KL       ++S K + +
Sbjct: 567 EKEAIELREAVEQ-QKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCL 625

Query: 340 DERQTVRQVLDNLMDKS 356
            E QT+  +L  L + S
Sbjct: 626 IEAQTMEALLALLPELS 642


>gi|110611220 ribosome binding protein 1 [Homo sapiens]
          Length = 977

 Score = 36.2 bits (82), Expect = 0.096
 Identities = 70/317 (22%), Positives = 123/317 (38%), Gaps = 54/317 (17%)

Query: 60  TNMANFSYRFSIYNLNEALNQGETVDLDALMADLCSIEQELSSIGSGNSKRQITETKATQ 119
           T +A      SI  L +ALNQ  +       A+L  + QELS +    SK  + +++A +
Sbjct: 360 TQLARLQQENSI--LRDALNQATSQVESKQNAELAKLRQELSKV----SKELVEKSEAVR 413

Query: 120 KLPVSRHTLKHGTLKGLSSSSNRIAKPSHASYSLDDVTAQLEQASLSMDEAAQQSVLEDT 179
           +    R  L+              AK +    + +    QL+ +    +EA Q+ + E +
Sbjct: 414 QDEQQRKALE--------------AKAA----AFEKQVLQLQASHRESEEALQKRLDEVS 455

Query: 180 KPLVTNQHRRTASAGTVSD-----------AEVHSISNSSHSSITSAASSMDSLDIDKVT 228
           + L    H +++ A   +D           AE+HS   SS + + S    +  L      
Sbjct: 456 RELC---HTQSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGL------ 506

Query: 229 RPQELDLTHQGQPITEHAISLRC--SSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNI 286
             Q  +   +   +TE   S+     + QA+   D    QAE        +E    +  +
Sbjct: 507 HGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSGL 566

Query: 287 AGKPSHLLTKEEQAAKLKAEKIR-------VALEKIKEAQVKKLVIRVHMSDDSSKTMMV 339
             +   L    EQ  K+K   +R        AL   ++A  +KL       ++S K + +
Sbjct: 567 EKEAIELREAVEQ-QKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCL 625

Query: 340 DERQTVRQVLDNLMDKS 356
            E QT+  +L  L + S
Sbjct: 626 IEAQTMEALLALLPELS 642


>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
           [Homo sapiens]
          Length = 1046

 Score = 36.2 bits (82), Expect = 0.096
 Identities = 54/215 (25%), Positives = 96/215 (44%), Gaps = 36/215 (16%)

Query: 179 TKPLVTNQHRRTASAGTVSDAEVHSISNSSHSSITSAASSMDSLDIDKVTRPQELDLTHQ 238
           T P    + +R A   +   A  HS S+SS SS++S ASS+         RP    L  +
Sbjct: 293 TSPAKAKKTKRMAMGVS---ALTHSPSSSSISSVSSVASSVGG-------RPSRSGLLTE 342

Query: 239 GQPITEHAIS----LRCSSKQAKRHIDFTEEQAELTPHSYLDRETSLLLRNIAGKPSHLL 294
                   IS    L+ + K+ ++HI+             L  E  L    +A   SH+ 
Sbjct: 343 TSSRYARKISGTTALQEALKEKQQHIE------------QLLAERDLERAEVAKATSHIC 390

Query: 295 TKEEQAAKLKAEK---IRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDN 351
             E++ A LKA+    +  A EK++ A++    +R    D S++  + +ER+ V  +   
Sbjct: 391 EVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQ--LEEERRKVEDLQFR 448

Query: 352 LMDKSHCGYSLDWSLVETVSELQMERIFEDHENLV 386
           + ++     S+    +ET ++L+  RI E  ++L+
Sbjct: 449 VEEE-----SITKGDLETQTQLEHARIGELEQSLL 478


>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
           [Homo sapiens]
          Length = 438

 Score = 36.2 bits (82), Expect = 0.096
 Identities = 30/147 (20%), Positives = 61/147 (41%), Gaps = 14/147 (9%)

Query: 465 WKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKH 524
           WKK + +L+ S +Y+     A+ +     F+ L    V    + + K      +   + H
Sbjct: 63  WKKFWVILKGSSLYWYSNQMAEKADG---FVNLPDFTVERASECKKK------HAFKISH 113

Query: 525 PQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSS 584
           PQI+       Y   ++V+ ++ W+N +  A   ++     +E    +E      +  + 
Sbjct: 114 PQIK-----TFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETP 168

Query: 585 SIKSGSSSSSIPESQSNHSNQSDSGVS 611
                S + S+   Q++ S+ S SG S
Sbjct: 169 PPPHASQTQSLTAQQASSSSPSLSGTS 195


>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
           [Homo sapiens]
          Length = 438

 Score = 36.2 bits (82), Expect = 0.096
 Identities = 30/147 (20%), Positives = 61/147 (41%), Gaps = 14/147 (9%)

Query: 465 WKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKH 524
           WKK + +L+ S +Y+     A+ +     F+ L    V    + + K      +   + H
Sbjct: 63  WKKFWVILKGSSLYWYSNQMAEKADG---FVNLPDFTVERASECKKK------HAFKISH 113

Query: 525 PQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSS 584
           PQI+       Y   ++V+ ++ W+N +  A   ++     +E    +E      +  + 
Sbjct: 114 PQIK-----TFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETP 168

Query: 585 SIKSGSSSSSIPESQSNHSNQSDSGVS 611
                S + S+   Q++ S+ S SG S
Sbjct: 169 PPPHASQTQSLTAQQASSSSPSLSGTS 195


>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
           sapiens]
          Length = 437

 Score = 36.2 bits (82), Expect = 0.096
 Identities = 30/147 (20%), Positives = 61/147 (41%), Gaps = 14/147 (9%)

Query: 465 WKKRYFLLRASGIYYVPKGKAKVSRDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKH 524
           WKK + +L+ S +Y+     A+ +     F+ L    V    + + K      +   + H
Sbjct: 62  WKKFWVILKGSSLYWYSNQMAEKADG---FVNLPDFTVERASECKKK------HAFKISH 112

Query: 525 PQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRTESAYDWTSLSSS 584
           PQI+       Y   ++V+ ++ W+N +  A   ++     +E    +E      +  + 
Sbjct: 113 PQIK-----TFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETP 167

Query: 585 SIKSGSSSSSIPESQSNHSNQSDSGVS 611
                S + S+   Q++ S+ S SG S
Sbjct: 168 PPPHASQTQSLTAQQASSSSPSLSGTS 194


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.126    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,423,439
Number of Sequences: 37866
Number of extensions: 951549
Number of successful extensions: 4695
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 112
Number of HSP's that attempted gapping in prelim test: 4368
Number of HSP's gapped (non-prelim): 319
length of query: 644
length of database: 18,247,518
effective HSP length: 109
effective length of query: 535
effective length of database: 14,120,124
effective search space: 7554266340
effective search space used: 7554266340
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.